                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
       Samuels, Yardena R.
       Xiaomu, Wei
 
<120>  TRRAP AND GRIN2A MUTATIONS AND USE THEREOF FOR THE DIAGNOSIS AND 
       TREATMENT OF MELANOMA

<130>  4239-86201-02

<150>  US 61/462,471
<151>  2001-02-02

<160>  72    

<170>  PatentIn version 3.5

<210>  1
<211>  11493
<212>  DNA
<213>  Homo sapiens

<400>  1
atggcgtttg ttgcaacaca gggggccacg gtggttgacc agaccacttt gatgaaaaag       60

taccttcagt ttgtggcagc tctcacagat gtgaatacac ctgatgaaac aaagttgaaa      120

atgatgcaag aagttagtga aaattttgag aatgtcacgt catctcctca gtattctaca      180

ttcctagaac atatcatccc tcgattcctt acatttctcc aagatggaga agttcagttt      240

cttcaggaga aaccagcaca gcaactgcgg aagctcgtac ttgaaataat tcatagaata      300

ccaaccaacg aacatcttcg tcctcacaca aaaaatgttt tgtctgtgat gtttcgcttt      360

ttagagacgg aaaatgaaga aaatgttctt atttgtctaa gaataattat tgagctacac      420

aaacagttca ggccaccgat cacacaagaa attcatcatt ttctggattt tgtgaaacag      480

atttacaagg agcttccaaa agtagtgaac cgctactttg agaaccctca agtgatcccc      540

gagaacacag tgcctccccc agaaatggtt ggtatgataa caacgattgc tgtgaaagtc      600

aacccggagc gtgaggacag tgagactcga acacattcca tcattccgag gggatcactt      660

tctctgaaag tgttggcaga attgcccatt attgttgttt taatgtatca gctctacaaa      720

ctgaacatcc acaatgttgt tgctgagttt gtgcccttga tcatgaacac cattgccatt      780

caggtgtctg cacaagcgag gcaacataag ctttacaaca aggagttgta tgctgacttc      840

attgctgctc agattaaaac attgtcattt ttagcttaca ttatcaggat ttaccaggag      900

ttggtgacta agtattctca gcagatggtg aaaggaatgc tccagttact ttcaaattgt      960

ccagcagaga ctgcacacct cagaaaggag cttctgattg ctgccaaaca catcctcacc     1020

acagagctga gaaaccagtt cattccttgc atggacaagc tgtttgatga atccatacta     1080

attggctcag gatatactgc cagagagact ctaaggcccc tcgcctacag cacgctggcc     1140

gacctcgtgc accatgtccg ccagcacctg cccctcagcg acctctccct cgccgtccag     1200

ctcttcgcca agaacatcga cgatgagtcc ctgcccagca gcatccagac catgtcctgc     1260

aagctcctgc tgaacctggt ggactgcatc cgttccaaga gcgagcagga gagtggcaat     1320

gggagagacg tcctgatgcg gatgctggag gttttcgttc tcaaattcca cacaattgct     1380

cggtaccagc tctctgccat ttttaagaag tgtaagcctc agtcagaact tggagccgtg     1440

gaagcagctc tgcctggggt gcccactgcc cctgcagctc ctggccctgc tccctcccca     1500

gcccctgtcc ctgccccacc tccacccccg cccccacccc cacctgccac ccctgtgacc     1560

ccggcccccg tgcctccctt cgagaagcaa ggagaaaagg acaaggaaga caagcagaca     1620

ttccaagtca cagactgtcg aagtttggtc aaaaccttgg tgtgtggtgt caagacaatc     1680

acgtggggca taacatcatg caaagcacct ggtgaagctc agttcattcc caacaagcag     1740

ttacaaccca aagagacaca gatttacatc aaacttgtga aatatgcaat gcaagcttta     1800

gatatttatc aggtccagat agcaggaaat ggacagacat acatccgtgt ggccaactgc     1860

cagactgtga gaatgaaaga ggagaaggag gtattggagc atttcgctgg tgtgttcaca     1920

atgatgaacc ccttaacgtt caaagaaatc ttccaaacta cggtccctta tatggtggag     1980

agaatctcaa aaaattatgc tcttcagatt gttgccaatt ccttcttggc aaatcctact     2040

acctctgctc tgtttgctac gattctggtg gaatatctcc ttgatcgcct gccagaaatg     2100

ggctccaacg tggagctctc caacctgtac ctcaagctgt tcaagctggt ctttggctct     2160

gtctccctct ttgcagctga aaatgaacaa atgctgaagc ctcacttgca caagattgtg     2220

aacagctcta tggagctcgc gcagactgcc aaggaaccct acaactactt cttgctgcta     2280

cgggcgctgt ttcgctctat tggtggaggt agccacgatc tcttgtatca ggagttcttg     2340

cctctccttc caaacctcct gcaagggctg aacatgcttc agagtggcct gcacaagcag     2400

cacatgaagg acctctttgt ggagctgtgt ctcaccgtcc ctgtgcggct gagctcgctt     2460

ttgccgtacc tgcccatgct tatggatccc ttggtgtctg cactcaatgg gtctcagaca     2520

ttggtcagcc aaggcctcag gacgctggag ctgtgtgtgg acaacctgca gcccgacttc     2580

ctctacgacc acatccagcc ggtgcgcgca gagctcatgc aggctctgtg gcgcacctta     2640

cgcaaccctg ctgacagcat ctcccacgtg gcctaccgtg tgctcggtaa gtttggcggc     2700

agtaacagga agatgctgaa ggagtcgcag aagctgcact acgttgtgac cgaggttcag     2760

ggccccagca tcactgtgga gttttccgac tgcaaagctt ctctccagct ccccatggag     2820

aaggccattg aaactgctct ggactgcctg aaaagcgcca acactgagcc ctactaccgg     2880

aggcaggcgt gggaagtgat caaatgcttc ctggtggcca tgatgagcct ggaggacaac     2940

aagcacgcac tctaccagct cctggcacac cccaacttta cagaaaagac catccccaat     3000

gttatcatct cacatcgcta caaagcccag gacactccag cccggaagac ttttgagcag     3060

gccctgacag gcgccttcat gtctgctgtc attaaggacc tgcggcccag cgccctgccc     3120

tttgtcgcca gcttgatccg ccactatacg atggtggcag tcgcccagca gtgtggccct     3180

ttcttgctgc cttgctacca ggtgggcagc cagcccagca cagccatgtt tcacagtgaa     3240

gaaaatggct cgaaaggaat ggatcctttg gttctcattg atgcaattgc tatttgtatg     3300

gcatatgaag aaaaggagct ttgcaaaatc ggggaggtgg ccctagctgt gatatttgat     3360

gttgcaagta tcatcctggg ctccaaggag agggcctgcc agctgcccct gttttcttac     3420

atcgtggagc gcctgtgtgc atgttgttat gaacaggcgt ggtatgcaaa gctggggggt     3480

gtggtgtcta ttaagtttct catggagcgg ctgcctctca cttgggttct ccagaaccag     3540

cagacattcc tgaaagcact tctctttgtc atgatggact taactggaga ggtttccaat     3600

ggggcagtcg ctatggcaaa gaccacgctg gagcagcttc tgatgcggtg cgcaacgcct     3660

ttaaaagacg aggagagagc cgaagagatc gtggccgccc aggaaaagtc tttccaccat     3720

gtgacacacg acttggttcg agaagtcacc tctccaaact ccactgtgag gaagcaggcc     3780

atgcattcgc tgcaggtgtt ggcccaggtc actgggaaga gtgtcacggt gatcatggaa     3840

ccccacaaag aggtcctgca ggatatggtc ccccctaaga agcacctgct ccgacaccag     3900

cctgccaacg cacagattgg cctgatggag gggaacacgt tctgtaccac gttgcagccc     3960

aggctcttca caatggacct taacgtggtg gagcataagg tgttctacac agagctgttg     4020

aatttgtgtg aggctgaaga ttcagcttta acaaagctgc cctgttataa aagccttccg     4080

tcactcgtac ctttacgaat tgcggcatta aatgcacttg ctgcctgcaa ttaccttcct     4140

cagtccaggg agaaaatcat cgctgcactc ttcaaagccc tgaattccac caatagtgag     4200

ctccaagagg ccggagaagc ctgtatgaga aagtttttag aaggtgctac catagaagtc     4260

gatcaaatcc acacacatat gcgacctttg ctgatgatgc tgggagatta ccggagcttg     4320

acgctgaatg ttgtgaatcg cctgacttcg gtcacgaggc tcttcccaaa ttccttcaat     4380

gataaatttt gtgatcagat gatgcaacat ctgcgcaagt ggatggaagt ggtggtgatc     4440

acccacaaag ggggccagag gagcgacgga aacgaaatga agatttgctc agcaattata     4500

aacctttttc atctgatccc ggctgctcct cagacactgg tgaagccttt gctagaggtt     4560

gtcatgaaaa cggagcgggc gatgctgatc gaggcgggga gtccattccg agagcccctg     4620

atcaagttcc tgactcgaca tccctcgcag acagtggagc tgttcatgat ggaagccaca     4680

ctgaacgatc cccagtggag cagaatgttt atgagttttt taaaacacaa agacgccaga     4740

cctctgcggg atgtgctggc tgccaacccc aacaggttca tcaccctgct gctgccgggg     4800

ggtgcccaga cggctgtgcg ccccggttcg cccagcacca gcaccatgcg cctggacctc     4860

cagttccagg ccatcaagat cataagcatt atagtgaaaa acgatgactc ctggctggcc     4920

agccagcact ctctggtgag ccagttgcga cgtgtgtggg tgagtgagaa cttccaagag     4980

aggcaccgca aggagaacat ggcagccacc aactggaagg agcccaagct gctggcctac     5040

tgcctgctga actactgcaa aaggaattac ggagatatag aattgctgtt ccagctgctc     5100

cgagccttta ctggtcgttt tctctgcaac atgacattct taaaagagta tatggaggaa     5160

gagattccca aaaattacag catcgctcag aaacgtgccc tgttctttcg ctttgtagac     5220

ttcaacgacc ccaacttcgg agatgaatta aaagctaaag ttctgcagca tatcttgaat     5280

cctgctttct tgtacagctt tgagaagggg gaaggagagc agctcttggg acctcccaat     5340

ccagaaggag ataacccaga aagcatcacc agtgtgttta ttaccaaggt cctggacccc     5400

gagaagcagg cggacatgct ggactcgctg cggatctacc tgctgcagta cgccacgctg     5460

ctggtggagc acgcccccca ccacatccat gacaacaaca agaaccgcaa cagcaagctg     5520

cgccgcctca tgaccttcgc ctggccctgc ctgctctcca aggcctgcgt ggacccagcc     5580

tgcaagtaca gcggacactt gctcctggcg cacattatcg ccaaattcgc catacacaag     5640

aagatcgtcc tgcaggtttt tcatagtctc ctcaaggctc acgcaatgga agctcgagcg     5700

atcgtcagac aggcgatggc cattctgacc ccggcggtgc cggccaggat ggaggacggg     5760

caccagatgc tgacccactg gacccggaag atcattgtgg aggaggggca caccgtcccg     5820

cagctggtcc acattctgca cctgatagtg caacacttca aggtgtacta cccggtacgg     5880

caccacttgg tgcagcacat ggtgagcgcc atgcagaggc tgggcttcac gcccagtgtc     5940

accatcgagc agaggcggct ggccgtggac ctgtctgaag tcgtcatcaa gtgggagctg     6000

cagaggatca aggaccagca gccggattca gatatggacc caaattccag tggagaagga     6060

gtcaattctg tctcatcctc cattaagaga ggcctgtccg tggattctgc ccaggaagtg     6120

aaacgcttta ggacggccac cggagccatc agtgcagtct ttgggaggag ccagtcgcta     6180

cctggagcag actctctcct cgccaagccc attgacaagc agcacacaga cactgtggtg     6240

aacttcctta tccgcgtggc ctgtcaggtt aatgacaaca ccaacacagc ggggtcccct     6300

ggggaggtgc tctctcgccg gtgtgtgaac cttctgaaga ctgcgttgcg gccagacatg     6360

tggcccaagt ccgaactcaa gctgcagtgg ttcgacaagc tgctgatgac tgtggagcag     6420

ccaaaccaag tgaactatgg gaatatctgc acgggcctag aagtgctgag cttcctgcta     6480

actgtcctcc agtccccagc catcctcagt agcttcaaac ctctgcagcg tggaattgcc     6540

gcctgcatga catgtggaaa caccaaggtg ttgcgagccg tccacagcct tctctcgcgc     6600

ctgatgagca ttttcccaac agagccgagt acttccagtg tggcctccaa atatgaagag     6660

ctggagtgcc tctacgcagc cgtcggaaag gtcatctatg aagggctcac caactacgag     6720

aaggccacca atgccaatcc ctcccagctc ttcgggaccc ttatgatcct caagtctgcc     6780

tgcagcaaca accccagcta catagacagg ctgatctccg tctttatgcg ctccctgcag     6840

aagatggtcc gggagcattt aaaccctcag gcagcgtcag gaagcaccga agccacctca     6900

ggtacaagcg agctggtgat gctgagtctg gagctggtga agacgcgcct ggcagtgatg     6960

agcatggaga tgcggaagaa cttcatccag gccatcctga catccctcat cgaaaaatca     7020

ccagatgcca aaatcctccg ggctgtggtc aaaatcgtgg aagaatgggt caagaataac     7080

tccccaatgg cagccaatca gacacctaca ctccgggaga agtccatttt gcttgtgaag     7140

atgatgactt acatagaaaa acgctttccg gaagaccttg aattaaatgc ccagttttta     7200

gatcttgtta actatgtcta cagggatgag accctctctg gcagcgagct gacggcgaaa     7260

cttgagcctg cctttctctc tgggctgcgc tgtgcccagc cactcatcag ggcaaagttt     7320

ttcgaggttt ttgacaactc catgaaacgt cgtgtctacg agcgcttgct ctatgtgacc     7380

tgttcgcaga actgggaagc catggggaac cacttctgga tcaagcagtg cattgagctg     7440

cttctggccg tgtgtgagaa gagcaccccc attggcacca gctgccaagg agccatgctc     7500

ccgtccatca ccaacgtcat caacctggcc gatagccacg accgtgccgc cttcgccatg     7560

gtcacacatg tcaagcagga gccccgggag cgggagaaca gcgagtccaa agaggaggat     7620

gtagagatag acatcgaact agctcctggg gatcagacca gcacgcccaa aaccaaagaa     7680

ctttcagaaa aggacattgg aaaccagctg cacatgctaa ccaacaggca cgacaagttt     7740

ctggacactc tccgagaggt gaagactgga gcgctgctca gcgctttcgt tcagctgtgc     7800

cacatttcca cgacgctggc agagaagacg tgggtccagc ttttccccag attgtggaag     7860

atcctctctg acagacagca gcatgcactc gcgggtgaga taagtccatt tctgtgcagc     7920

ggcagtcacc aggtgcagcg ggactgccag cccagcgcgc tgaactgctt tgtggaagcc     7980

atgtcccagt gcgtgccgcc aatccccatc cgaccctgcg tcctgaagta cctggggaag     8040

acacacaacc tctggttccg gtccacgctg atgttggagc accaggcttt tgaaaagggt     8100

ctgagtcttc agattaagcc gaagcaaaca acggagtttt atgagcagga gagcatcacc     8160

ccgccgcagc aggagatact ggattccctt gcggagcttt actccctgtt acaagaggaa     8220

gatatgtggg ctggtctgtg gcagaagcgg tgcaagtact cggagacagc gactgcgatt     8280

gcttacgagc agcacgggtt ctttgagcag gcacaagaat cctatgaaaa ggcaatggat     8340

aaagccaaaa aagaacatga gaggagtaac gcctcccctg ctattttccc tgaataccag     8400

ctctgggaag accactggat tcgatgctcc aaggaattga accagtggga agccctgacg     8460

gagtacggtc agtccaaagg ccacatcaac ccctacctcg tcctggagtg cgcctggcgg     8520

gtgtccaact ggactgccat gaaggaggcg ctggtgcagg tggaagtgag ctgtccgaag     8580

gagatggcct ggaaggtgaa catgtaccgc ggatacctgg ccatctgcca ccccgaggag     8640

cagcagctca gcttcatcga gcgcctggtg gagatggcca gcagcctggc catccgcgag     8700

tggcggcggc tgccccacgt agtgtcccac gtgcacacgc ctctcctaca ggcagcccag     8760

caaatcatcg aactccagga agctgcacaa atcaacgcag gcttacagcc aaccaacctg     8820

ggaaggaaca acagcctgca cgacatgaag acggtggtga agacctggag gaaccgactg     8880

cccatcgtgt ctgacgactt gtcccactgg agcagcatct tcatgtggag gcagcatcat     8940

taccaggcga ttgtaactgc ctatgagaat agctctcagc atgatcccag ttcaaataac     9000

gctatgcttg gggttcatgc atcagcttca gcgatcatcc agtatggaaa aatcgcccgg     9060

aaacaaggac tggtcaatgt agctctggat atattaagtc ggattcatac tattccaact     9120

gttcctatcg tggattgctt ccagaagatt cgacagcaag ttaaatgcta cctccagctg     9180

gcaggcgtca tgggcaaaaa cgagtgcatg cagggccttg aagttattga atctacaaat     9240

ttaaaatact tcacaaaaga gatgacagcc gaattttatg cactgaaggg aatgttcttg     9300

gctcagatca acaagtccga ggaggcaaac aaagccttct ctgcagctgt gcagatgcac     9360

gatgtgctgg tgaaagcctg ggccatgtgg ggcgactacc tggagaacat ctttgtgaag     9420

gagcggcagc tgcacctggg cgtgtctgcc atcacctgct acctgcacgc ctgccggcat     9480

cagaacgaga gcaaatcgag gaaatactta gccaaggtgc tgtggctttt gagttttgat     9540

gatgacaaaa acactttggc agatgccgtc gacaagtact gcattggtgt gccacccatc     9600

cagtggctgg cctggatccc acagctgctc acctgcctgg ttggctcgga gggaaagctg     9660

ctcttgaacc tcattagcca ggttggacgc gtgtatcccc aagcggtcta ctttcccatc     9720

cggaccctgt acctgaccct gaaaatagaa cagcgggaac gctacaagag cgatccaggg     9780

cccataagag caacagcacc catgtggcgc tgcagccgaa tcatgcacat gcagcgagag     9840

ctccacccca cccttctgtc ttccctggaa ggcatcgtcg atcagatggt ctggttcaga     9900

gaaaattggc atgaagaggt tctcaggcag ctccaacagg gcctggcgaa atgttactcc     9960

gtggcgtttg agaaaagtgg agcggtgtcc gatgctaaaa tcacccccca cactctcaat    10020

tttgtgaaga agttggtgag cacgtttggg gtgggcctgg agaatgtgtc caacgtctcg    10080

accatgttct ccagcgcagc ctctgagtct ctggcccggc gggcgcaggc cactgcacaa    10140

gaccctgtct ttcagaagct gaaaggccag ttcacgacgg attttgactt cagcgttcca    10200

ggatccatga agcttcataa tcttatttct aagttgaaaa agtggatcaa aatcttggag    10260

gccaagacca agcaactccc caaattcttc ctcatagagg aaaagtgccg gttcttgagc    10320

aatttctcgg cacagacagc tgaagtggaa attcctgggg agtttctgat gccaaagcca    10380

acgcattatt acatcaagat tgcacggttc atgccccggg tagagattgt gcagaagcac    10440

aacaccgcag cccggcggct gtacatccgg ggacacaatg gcaagatcta cccatacctc    10500

gtcatgaacg acgcctgcct cacagagtca cggcgagagg agcgtgtgtt gcagctgctg    10560

cgtctgctga acccctgttt ggagaagaga aaggagacca ccaagaggca cttgtttttc    10620

acagtgcccc gggttgtggc agtttcccca cagatgcgcc tcgtggagga caacccctct    10680

tcactttccc ttgtggagat ctacaagcag cgctgcgcca agaagggcat cgagcatgac    10740

aaccccatct cccgttacta tgaccggctg gctacggtgc aggcgcgggg aacccaagcc    10800

agccaccagg tcctccgcga catcctcaag gaggttcaga gtaacatggt gccgcgcagc    10860

atgctcaagg agtgggcgct gcacaccttc cccaatgcca cggactactg gacgttccgg    10920

aagatgttca ccatccagct ggctctgata ggcttcgcgg aattcgtcct gcatttaaat    10980

agactcaacc ccgagatgtt acagatcgct caggacactg gcaaactgaa tgttgcctac    11040

tttcgatttg acataaacga cgcgactgga gacctggatg ccaaccgtcc tgtcccattt    11100

cgactcacgc ccaacatttc tgagtttctg accaccatcg gggtctccgg cccgttgaca    11160

gcgtccatga ttgcggtcgc ccggtgcttc gcccagccaa actttaaggt ggatggcatt    11220

ctgaaaacgg ttctccggga cgagatcatt gcttggcaca aaaaaacaca agaggacacg    11280

tcctctcctc tctcggccgc cgggcagcca gagaacatgg acagccagca actggtgtcc    11340

ctggttcaga aagccgtcac cgccatcatg acccgcctgc acaacctcgc ccagttcgaa    11400

ggcggggaaa gcaaggtgaa caccctggtg gccgcggcaa acagcctgga caatctgtgc    11460

cgcatggacc ccgcctggca cccctggctg tga                                 11493


<210>  2
<211>  3830
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Phe Val Ala Thr Gln Gly Ala Thr Val Val Asp Gln Thr Thr 
1               5                   10                  15      


Leu Met Lys Lys Tyr Leu Gln Phe Val Ala Ala Leu Thr Asp Val Asn 
            20                  25                  30          


Thr Pro Asp Glu Thr Lys Leu Lys Met Met Gln Glu Val Ser Glu Asn 
        35                  40                  45              


Phe Glu Asn Val Thr Ser Ser Pro Gln Tyr Ser Thr Phe Leu Glu His 
    50                  55                  60                  


Ile Ile Pro Arg Phe Leu Thr Phe Leu Gln Asp Gly Glu Val Gln Phe 
65                  70                  75                  80  


Leu Gln Glu Lys Pro Ala Gln Gln Leu Arg Lys Leu Val Leu Glu Ile 
                85                  90                  95      


Ile His Arg Ile Pro Thr Asn Glu His Leu Arg Pro His Thr Lys Asn 
            100                 105                 110         


Val Leu Ser Val Met Phe Arg Phe Leu Glu Thr Glu Asn Glu Glu Asn 
        115                 120                 125             


Val Leu Ile Cys Leu Arg Ile Ile Ile Glu Leu His Lys Gln Phe Arg 
    130                 135                 140                 


Pro Pro Ile Thr Gln Glu Ile His His Phe Leu Asp Phe Val Lys Gln 
145                 150                 155                 160 


Ile Tyr Lys Glu Leu Pro Lys Val Val Asn Arg Tyr Phe Glu Asn Pro 
                165                 170                 175     


Gln Val Ile Pro Glu Asn Thr Val Pro Pro Pro Glu Met Val Gly Met 
            180                 185                 190         


Ile Thr Thr Ile Ala Val Lys Val Asn Pro Glu Arg Glu Asp Ser Glu 
        195                 200                 205             


Thr Arg Thr His Ser Ile Ile Pro Arg Gly Ser Leu Ser Leu Lys Val 
    210                 215                 220                 


Leu Ala Glu Leu Pro Ile Ile Val Val Leu Met Tyr Gln Leu Tyr Lys 
225                 230                 235                 240 


Leu Asn Ile His Asn Val Val Ala Glu Phe Val Pro Leu Ile Met Asn 
                245                 250                 255     


Thr Ile Ala Ile Gln Val Ser Ala Gln Ala Arg Gln His Lys Leu Tyr 
            260                 265                 270         


Asn Lys Glu Leu Tyr Ala Asp Phe Ile Ala Ala Gln Ile Lys Thr Leu 
        275                 280                 285             


Ser Phe Leu Ala Tyr Ile Ile Arg Ile Tyr Gln Glu Leu Val Thr Lys 
    290                 295                 300                 


Tyr Ser Gln Gln Met Val Lys Gly Met Leu Gln Leu Leu Ser Asn Cys 
305                 310                 315                 320 


Pro Ala Glu Thr Ala His Leu Arg Lys Glu Leu Leu Ile Ala Ala Lys 
                325                 330                 335     


His Ile Leu Thr Thr Glu Leu Arg Asn Gln Phe Ile Pro Cys Met Asp 
            340                 345                 350         


Lys Leu Phe Asp Glu Ser Ile Leu Ile Gly Ser Gly Tyr Thr Ala Arg 
        355                 360                 365             


Glu Thr Leu Arg Pro Leu Ala Tyr Ser Thr Leu Ala Asp Leu Val His 
    370                 375                 380                 


His Val Arg Gln His Leu Pro Leu Ser Asp Leu Ser Leu Ala Val Gln 
385                 390                 395                 400 


Leu Phe Ala Lys Asn Ile Asp Asp Glu Ser Leu Pro Ser Ser Ile Gln 
                405                 410                 415     


Thr Met Ser Cys Lys Leu Leu Leu Asn Leu Val Asp Cys Ile Arg Ser 
            420                 425                 430         


Lys Ser Glu Gln Glu Ser Gly Asn Gly Arg Asp Val Leu Met Arg Met 
        435                 440                 445             


Leu Glu Val Phe Val Leu Lys Phe His Thr Ile Ala Arg Tyr Gln Leu 
    450                 455                 460                 


Ser Ala Ile Phe Lys Lys Cys Lys Pro Gln Ser Glu Leu Gly Ala Val 
465                 470                 475                 480 


Glu Ala Ala Leu Pro Gly Val Pro Thr Ala Pro Ala Ala Pro Gly Pro 
                485                 490                 495     


Ala Pro Ser Pro Ala Pro Val Pro Ala Pro Pro Pro Pro Pro Pro Pro 
            500                 505                 510         


Pro Pro Pro Ala Thr Pro Val Thr Pro Ala Pro Val Pro Pro Phe Glu 
        515                 520                 525             


Lys Gln Gly Glu Lys Asp Lys Glu Asp Lys Gln Thr Phe Gln Val Thr 
    530                 535                 540                 


Asp Cys Arg Ser Leu Val Lys Thr Leu Val Cys Gly Val Lys Thr Ile 
545                 550                 555                 560 


Thr Trp Gly Ile Thr Ser Cys Lys Ala Pro Gly Glu Ala Gln Phe Ile 
                565                 570                 575     


Pro Asn Lys Gln Leu Gln Pro Lys Glu Thr Gln Ile Tyr Ile Lys Leu 
            580                 585                 590         


Val Lys Tyr Ala Met Gln Ala Leu Asp Ile Tyr Gln Val Gln Ile Ala 
        595                 600                 605             


Gly Asn Gly Gln Thr Tyr Ile Arg Val Ala Asn Cys Gln Thr Val Arg 
    610                 615                 620                 


Met Lys Glu Glu Lys Glu Val Leu Glu His Phe Ala Gly Val Phe Thr 
625                 630                 635                 640 


Met Met Asn Pro Leu Thr Phe Lys Glu Ile Phe Gln Thr Thr Val Pro 
                645                 650                 655     


Tyr Met Val Glu Arg Ile Ser Lys Asn Tyr Ala Leu Gln Ile Val Ala 
            660                 665                 670         


Asn Ser Phe Leu Ala Asn Pro Thr Thr Ser Ala Leu Phe Ala Thr Ile 
        675                 680                 685             


Leu Val Glu Tyr Leu Leu Asp Arg Leu Pro Glu Met Gly Ser Asn Val 
    690                 695                 700                 


Glu Leu Ser Asn Leu Tyr Leu Lys Leu Phe Lys Leu Val Phe Gly Ser 
705                 710                 715                 720 


Val Ser Leu Phe Ala Ala Glu Asn Glu Gln Met Leu Lys Pro His Leu 
                725                 730                 735     


His Lys Ile Val Asn Ser Ser Met Glu Leu Ala Gln Thr Ala Lys Glu 
            740                 745                 750         


Pro Tyr Asn Tyr Phe Leu Leu Leu Arg Ala Leu Phe Arg Ser Ile Gly 
        755                 760                 765             


Gly Gly Ser His Asp Leu Leu Tyr Gln Glu Phe Leu Pro Leu Leu Pro 
    770                 775                 780                 


Asn Leu Leu Gln Gly Leu Asn Met Leu Gln Ser Gly Leu His Lys Gln 
785                 790                 795                 800 


His Met Lys Asp Leu Phe Val Glu Leu Cys Leu Thr Val Pro Val Arg 
                805                 810                 815     


Leu Ser Ser Leu Leu Pro Tyr Leu Pro Met Leu Met Asp Pro Leu Val 
            820                 825                 830         


Ser Ala Leu Asn Gly Ser Gln Thr Leu Val Ser Gln Gly Leu Arg Thr 
        835                 840                 845             


Leu Glu Leu Cys Val Asp Asn Leu Gln Pro Asp Phe Leu Tyr Asp His 
    850                 855                 860                 


Ile Gln Pro Val Arg Ala Glu Leu Met Gln Ala Leu Trp Arg Thr Leu 
865                 870                 875                 880 


Arg Asn Pro Ala Asp Ser Ile Ser His Val Ala Tyr Arg Val Leu Gly 
                885                 890                 895     


Lys Phe Gly Gly Ser Asn Arg Lys Met Leu Lys Glu Ser Gln Lys Leu 
            900                 905                 910         


His Tyr Val Val Thr Glu Val Gln Gly Pro Ser Ile Thr Val Glu Phe 
        915                 920                 925             


Ser Asp Cys Lys Ala Ser Leu Gln Leu Pro Met Glu Lys Ala Ile Glu 
    930                 935                 940                 


Thr Ala Leu Asp Cys Leu Lys Ser Ala Asn Thr Glu Pro Tyr Tyr Arg 
945                 950                 955                 960 


Arg Gln Ala Trp Glu Val Ile Lys Cys Phe Leu Val Ala Met Met Ser 
                965                 970                 975     


Leu Glu Asp Asn Lys His Ala Leu Tyr Gln Leu Leu Ala His Pro Asn 
            980                 985                 990         


Phe Thr Glu Lys Thr Ile Pro Asn  Val Ile Ile Ser His  Arg Tyr Lys 
        995                 1000                 1005             


Ala Gln  Asp Thr Pro Ala Arg  Lys Thr Phe Glu Gln  Ala Leu Thr 
    1010                 1015                 1020             


Gly Ala  Phe Met Ser Ala Val  Ile Lys Asp Leu Arg  Pro Ser Ala 
    1025                 1030                 1035             


Leu Pro  Phe Val Ala Ser Leu  Ile Arg His Tyr Thr  Met Val Ala 
    1040                 1045                 1050             


Val Ala  Gln Gln Cys Gly Pro  Phe Leu Leu Pro Cys  Tyr Gln Val 
    1055                 1060                 1065             


Gly Ser  Gln Pro Ser Thr Ala  Met Phe His Ser Glu  Glu Asn Gly 
    1070                 1075                 1080             


Ser Lys  Gly Met Asp Pro Leu  Val Leu Ile Asp Ala  Ile Ala Ile 
    1085                 1090                 1095             


Cys Met  Ala Tyr Glu Glu Lys  Glu Leu Cys Lys Ile  Gly Glu Val 
    1100                 1105                 1110             


Ala Leu  Ala Val Ile Phe Asp  Val Ala Ser Ile Ile  Leu Gly Ser 
    1115                 1120                 1125             


Lys Glu  Arg Ala Cys Gln Leu  Pro Leu Phe Ser Tyr  Ile Val Glu 
    1130                 1135                 1140             


Arg Leu  Cys Ala Cys Cys Tyr  Glu Gln Ala Trp Tyr  Ala Lys Leu 
    1145                 1150                 1155             


Gly Gly  Val Val Ser Ile Lys  Phe Leu Met Glu Arg  Leu Pro Leu 
    1160                 1165                 1170             


Thr Trp  Val Leu Gln Asn Gln  Gln Thr Phe Leu Lys  Ala Leu Leu 
    1175                 1180                 1185             


Phe Val  Met Met Asp Leu Thr  Gly Glu Val Ser Asn  Gly Ala Val 
    1190                 1195                 1200             


Ala Met  Ala Lys Thr Thr Leu  Glu Gln Leu Leu Met  Arg Cys Ala 
    1205                 1210                 1215             


Thr Pro  Leu Lys Asp Glu Glu  Arg Ala Glu Glu Ile  Val Ala Ala 
    1220                 1225                 1230             


Gln Glu  Lys Ser Phe His His  Val Thr His Asp Leu  Val Arg Glu 
    1235                 1240                 1245             


Val Thr  Ser Pro Asn Ser Thr  Val Arg Lys Gln Ala  Met His Ser 
    1250                 1255                 1260             


Leu Gln  Val Leu Ala Gln Val  Thr Gly Lys Ser Val  Thr Val Ile 
    1265                 1270                 1275             


Met Glu  Pro His Lys Glu Val  Leu Gln Asp Met Val  Pro Pro Lys 
    1280                 1285                 1290             


Lys His  Leu Leu Arg His Gln  Pro Ala Asn Ala Gln  Ile Gly Leu 
    1295                 1300                 1305             


Met Glu  Gly Asn Thr Phe Cys  Thr Thr Leu Gln Pro  Arg Leu Phe 
    1310                 1315                 1320             


Thr Met  Asp Leu Asn Val Val  Glu His Lys Val Phe  Tyr Thr Glu 
    1325                 1330                 1335             


Leu Leu  Asn Leu Cys Glu Ala  Glu Asp Ser Ala Leu  Thr Lys Leu 
    1340                 1345                 1350             


Pro Cys  Tyr Lys Ser Leu Pro  Ser Leu Val Pro Leu  Arg Ile Ala 
    1355                 1360                 1365             


Ala Leu  Asn Ala Leu Ala Ala  Cys Asn Tyr Leu Pro  Gln Ser Arg 
    1370                 1375                 1380             


Glu Lys  Ile Ile Ala Ala Leu  Phe Lys Ala Leu Asn  Ser Thr Asn 
    1385                 1390                 1395             


Ser Glu  Leu Gln Glu Ala Gly  Glu Ala Cys Met Arg  Lys Phe Leu 
    1400                 1405                 1410             


Glu Gly  Ala Thr Ile Glu Val  Asp Gln Ile His Thr  His Met Arg 
    1415                 1420                 1425             


Pro Leu  Leu Met Met Leu Gly  Asp Tyr Arg Ser Leu  Thr Leu Asn 
    1430                 1435                 1440             


Val Val  Asn Arg Leu Thr Ser  Val Thr Arg Leu Phe  Pro Asn Ser 
    1445                 1450                 1455             


Phe Asn  Asp Lys Phe Cys Asp  Gln Met Met Gln His  Leu Arg Lys 
    1460                 1465                 1470             


Trp Met  Glu Val Val Val Ile  Thr His Lys Gly Gly  Gln Arg Ser 
    1475                 1480                 1485             


Asp Gly  Asn Glu Met Lys Ile  Cys Ser Ala Ile Ile  Asn Leu Phe 
    1490                 1495                 1500             


His Leu  Ile Pro Ala Ala Pro  Gln Thr Leu Val Lys  Pro Leu Leu 
    1505                 1510                 1515             


Glu Val  Val Met Lys Thr Glu  Arg Ala Met Leu Ile  Glu Ala Gly 
    1520                 1525                 1530             


Ser Pro  Phe Arg Glu Pro Leu  Ile Lys Phe Leu Thr  Arg His Pro 
    1535                 1540                 1545             


Ser Gln  Thr Val Glu Leu Phe  Met Met Glu Ala Thr  Leu Asn Asp 
    1550                 1555                 1560             


Pro Gln  Trp Ser Arg Met Phe  Met Ser Phe Leu Lys  His Lys Asp 
    1565                 1570                 1575             


Ala Arg  Pro Leu Arg Asp Val  Leu Ala Ala Asn Pro  Asn Arg Phe 
    1580                 1585                 1590             


Ile Thr  Leu Leu Leu Pro Gly  Gly Ala Gln Thr Ala  Val Arg Pro 
    1595                 1600                 1605             


Gly Ser  Pro Ser Thr Ser Thr  Met Arg Leu Asp Leu  Gln Phe Gln 
    1610                 1615                 1620             


Ala Ile  Lys Ile Ile Ser Ile  Ile Val Lys Asn Asp  Asp Ser Trp 
    1625                 1630                 1635             


Leu Ala  Ser Gln His Ser Leu  Val Ser Gln Leu Arg  Arg Val Trp 
    1640                 1645                 1650             


Val Ser  Glu Asn Phe Gln Glu  Arg His Arg Lys Glu  Asn Met Ala 
    1655                 1660                 1665             


Ala Thr  Asn Trp Lys Glu Pro  Lys Leu Leu Ala Tyr  Cys Leu Leu 
    1670                 1675                 1680             


Asn Tyr  Cys Lys Arg Asn Tyr  Gly Asp Ile Glu Leu  Leu Phe Gln 
    1685                 1690                 1695             


Leu Leu  Arg Ala Phe Thr Gly  Arg Phe Leu Cys Asn  Met Thr Phe 
    1700                 1705                 1710             


Leu Lys  Glu Tyr Met Glu Glu  Glu Ile Pro Lys Asn  Tyr Ser Ile 
    1715                 1720                 1725             


Ala Gln  Lys Arg Ala Leu Phe  Phe Arg Phe Val Asp  Phe Asn Asp 
    1730                 1735                 1740             


Pro Asn  Phe Gly Asp Glu Leu  Lys Ala Lys Val Leu  Gln His Ile 
    1745                 1750                 1755             


Leu Asn  Pro Ala Phe Leu Tyr  Ser Phe Glu Lys Gly  Glu Gly Glu 
    1760                 1765                 1770             


Gln Leu  Leu Gly Pro Pro Asn  Pro Glu Gly Asp Asn  Pro Glu Ser 
    1775                 1780                 1785             


Ile Thr  Ser Val Phe Ile Thr  Lys Val Leu Asp Pro  Glu Lys Gln 
    1790                 1795                 1800             


Ala Asp  Met Leu Asp Ser Leu  Arg Ile Tyr Leu Leu  Gln Tyr Ala 
    1805                 1810                 1815             


Thr Leu  Leu Val Glu His Ala  Pro His His Ile His  Asp Asn Asn 
    1820                 1825                 1830             


Lys Asn  Arg Asn Ser Lys Leu  Arg Arg Leu Met Thr  Phe Ala Trp 
    1835                 1840                 1845             


Pro Cys  Leu Leu Ser Lys Ala  Cys Val Asp Pro Ala  Cys Lys Tyr 
    1850                 1855                 1860             


Ser Gly  His Leu Leu Leu Ala  His Ile Ile Ala Lys  Phe Ala Ile 
    1865                 1870                 1875             


His Lys  Lys Ile Val Leu Gln  Val Phe His Ser Leu  Leu Lys Ala 
    1880                 1885                 1890             


His Ala  Met Glu Ala Arg Ala  Ile Val Arg Gln Ala  Met Ala Ile 
    1895                 1900                 1905             


Leu Thr  Pro Ala Val Pro Ala  Arg Met Glu Asp Gly  His Gln Met 
    1910                 1915                 1920             


Leu Thr  His Trp Thr Arg Lys  Ile Ile Val Glu Glu  Gly His Thr 
    1925                 1930                 1935             


Val Pro  Gln Leu Val His Ile  Leu His Leu Ile Val  Gln His Phe 
    1940                 1945                 1950             


Lys Val  Tyr Tyr Pro Val Arg  His His Leu Val Gln  His Met Val 
    1955                 1960                 1965             


Ser Ala  Met Gln Arg Leu Gly  Phe Thr Pro Ser Val  Thr Ile Glu 
    1970                 1975                 1980             


Gln Arg  Arg Leu Ala Val Asp  Leu Ser Glu Val Val  Ile Lys Trp 
    1985                 1990                 1995             


Glu Leu  Gln Arg Ile Lys Asp  Gln Gln Pro Asp Ser  Asp Met Asp 
    2000                 2005                 2010             


Pro Asn  Ser Ser Gly Glu Gly  Val Asn Ser Val Ser  Ser Ser Ile 
    2015                 2020                 2025             


Lys Arg  Gly Leu Ser Val Asp  Ser Ala Gln Glu Val  Lys Arg Phe 
    2030                 2035                 2040             


Arg Thr  Ala Thr Gly Ala Ile  Ser Ala Val Phe Gly  Arg Ser Gln 
    2045                 2050                 2055             


Ser Leu  Pro Gly Ala Asp Ser  Leu Leu Ala Lys Pro  Ile Asp Lys 
    2060                 2065                 2070             


Gln His  Thr Asp Thr Val Val  Asn Phe Leu Ile Arg  Val Ala Cys 
    2075                 2080                 2085             


Gln Val  Asn Asp Asn Thr Asn  Thr Ala Gly Ser Pro  Gly Glu Val 
    2090                 2095                 2100             


Leu Ser  Arg Arg Cys Val Asn  Leu Leu Lys Thr Ala  Leu Arg Pro 
    2105                 2110                 2115             


Asp Met  Trp Pro Lys Ser Glu  Leu Lys Leu Gln Trp  Phe Asp Lys 
    2120                 2125                 2130             


Leu Leu  Met Thr Val Glu Gln  Pro Asn Gln Val Asn  Tyr Gly Asn 
    2135                 2140                 2145             


Ile Cys  Thr Gly Leu Glu Val  Leu Ser Phe Leu Leu  Thr Val Leu 
    2150                 2155                 2160             


Gln Ser  Pro Ala Ile Leu Ser  Ser Phe Lys Pro Leu  Gln Arg Gly 
    2165                 2170                 2175             


Ile Ala  Ala Cys Met Thr Cys  Gly Asn Thr Lys Val  Leu Arg Ala 
    2180                 2185                 2190             


Val His  Ser Leu Leu Ser Arg  Leu Met Ser Ile Phe  Pro Thr Glu 
    2195                 2200                 2205             


Pro Ser  Thr Ser Ser Val Ala  Ser Lys Tyr Glu Glu  Leu Glu Cys 
    2210                 2215                 2220             


Leu Tyr  Ala Ala Val Gly Lys  Val Ile Tyr Glu Gly  Leu Thr Asn 
    2225                 2230                 2235             


Tyr Glu  Lys Ala Thr Asn Ala  Asn Pro Ser Gln Leu  Phe Gly Thr 
    2240                 2245                 2250             


Leu Met  Ile Leu Lys Ser Ala  Cys Ser Asn Asn Pro  Ser Tyr Ile 
    2255                 2260                 2265             


Asp Arg  Leu Ile Ser Val Phe  Met Arg Ser Leu Gln  Lys Met Val 
    2270                 2275                 2280             


Arg Glu  His Leu Asn Pro Gln  Ala Ala Ser Gly Ser  Thr Glu Ala 
    2285                 2290                 2295             


Thr Ser  Gly Thr Ser Glu Leu  Val Met Leu Ser Leu  Glu Leu Val 
    2300                 2305                 2310             


Lys Thr  Arg Leu Ala Val Met  Ser Met Glu Met Arg  Lys Asn Phe 
    2315                 2320                 2325             


Ile Gln  Ala Ile Leu Thr Ser  Leu Ile Glu Lys Ser  Pro Asp Ala 
    2330                 2335                 2340             


Lys Ile  Leu Arg Ala Val Val  Lys Ile Val Glu Glu  Trp Val Lys 
    2345                 2350                 2355             


Asn Asn  Ser Pro Met Ala Ala  Asn Gln Thr Pro Thr  Leu Arg Glu 
    2360                 2365                 2370             


Lys Ser  Ile Leu Leu Val Lys  Met Met Thr Tyr Ile  Glu Lys Arg 
    2375                 2380                 2385             


Phe Pro  Glu Asp Leu Glu Leu  Asn Ala Gln Phe Leu  Asp Leu Val 
    2390                 2395                 2400             


Asn Tyr  Val Tyr Arg Asp Glu  Thr Leu Ser Gly Ser  Glu Leu Thr 
    2405                 2410                 2415             


Ala Lys  Leu Glu Pro Ala Phe  Leu Ser Gly Leu Arg  Cys Ala Gln 
    2420                 2425                 2430             


Pro Leu  Ile Arg Ala Lys Phe  Phe Glu Val Phe Asp  Asn Ser Met 
    2435                 2440                 2445             


Lys Arg  Arg Val Tyr Glu Arg  Leu Leu Tyr Val Thr  Cys Ser Gln 
    2450                 2455                 2460             


Asn Trp  Glu Ala Met Gly Asn  His Phe Trp Ile Lys  Gln Cys Ile 
    2465                 2470                 2475             


Glu Leu  Leu Leu Ala Val Cys  Glu Lys Ser Thr Pro  Ile Gly Thr 
    2480                 2485                 2490             


Ser Cys  Gln Gly Ala Met Leu  Pro Ser Ile Thr Asn  Val Ile Asn 
    2495                 2500                 2505             


Leu Ala  Asp Ser His Asp Arg  Ala Ala Phe Ala Met  Val Thr His 
    2510                 2515                 2520             


Val Lys  Gln Glu Pro Arg Glu  Arg Glu Asn Ser Glu  Ser Lys Glu 
    2525                 2530                 2535             


Glu Asp  Val Glu Ile Asp Ile  Glu Leu Ala Pro Gly  Asp Gln Thr 
    2540                 2545                 2550             


Ser Thr  Pro Lys Thr Lys Glu  Leu Ser Glu Lys Asp  Ile Gly Asn 
    2555                 2560                 2565             


Gln Leu  His Met Leu Thr Asn  Arg His Asp Lys Phe  Leu Asp Thr 
    2570                 2575                 2580             


Leu Arg  Glu Val Lys Thr Gly  Ala Leu Leu Ser Ala  Phe Val Gln 
    2585                 2590                 2595             


Leu Cys  His Ile Ser Thr Thr  Leu Ala Glu Lys Thr  Trp Val Gln 
    2600                 2605                 2610             


Leu Phe  Pro Arg Leu Trp Lys  Ile Leu Ser Asp Arg  Gln Gln His 
    2615                 2620                 2625             


Ala Leu  Ala Gly Glu Ile Ser  Pro Phe Leu Cys Ser  Gly Ser His 
    2630                 2635                 2640             


Gln Val  Gln Arg Asp Cys Gln  Pro Ser Ala Leu Asn  Cys Phe Val 
    2645                 2650                 2655             


Glu Ala  Met Ser Gln Cys Val  Pro Pro Ile Pro Ile  Arg Pro Cys 
    2660                 2665                 2670             


Val Leu  Lys Tyr Leu Gly Lys  Thr His Asn Leu Trp  Phe Arg Ser 
    2675                 2680                 2685             


Thr Leu  Met Leu Glu His Gln  Ala Phe Glu Lys Gly  Leu Ser Leu 
    2690                 2695                 2700             


Gln Ile  Lys Pro Lys Gln Thr  Thr Glu Phe Tyr Glu  Gln Glu Ser 
    2705                 2710                 2715             


Ile Thr  Pro Pro Gln Gln Glu  Ile Leu Asp Ser Leu  Ala Glu Leu 
    2720                 2725                 2730             


Tyr Ser  Leu Leu Gln Glu Glu  Asp Met Trp Ala Gly  Leu Trp Gln 
    2735                 2740                 2745             


Lys Arg  Cys Lys Tyr Ser Glu  Thr Ala Thr Ala Ile  Ala Tyr Glu 
    2750                 2755                 2760             


Gln His  Gly Phe Phe Glu Gln  Ala Gln Glu Ser Tyr  Glu Lys Ala 
    2765                 2770                 2775             


Met Asp  Lys Ala Lys Lys Glu  His Glu Arg Ser Asn  Ala Ser Pro 
    2780                 2785                 2790             


Ala Ile  Phe Pro Glu Tyr Gln  Leu Trp Glu Asp His  Trp Ile Arg 
    2795                 2800                 2805             


Cys Ser  Lys Glu Leu Asn Gln  Trp Glu Ala Leu Thr  Glu Tyr Gly 
    2810                 2815                 2820             


Gln Ser  Lys Gly His Ile Asn  Pro Tyr Leu Val Leu  Glu Cys Ala 
    2825                 2830                 2835             


Trp Arg  Val Ser Asn Trp Thr  Ala Met Lys Glu Ala  Leu Val Gln 
    2840                 2845                 2850             


Val Glu  Val Ser Cys Pro Lys  Glu Met Ala Trp Lys  Val Asn Met 
    2855                 2860                 2865             


Tyr Arg  Gly Tyr Leu Ala Ile  Cys His Pro Glu Glu  Gln Gln Leu 
    2870                 2875                 2880             


Ser Phe  Ile Glu Arg Leu Val  Glu Met Ala Ser Ser  Leu Ala Ile 
    2885                 2890                 2895             


Arg Glu  Trp Arg Arg Leu Pro  His Val Val Ser His  Val His Thr 
    2900                 2905                 2910             


Pro Leu  Leu Gln Ala Ala Gln  Gln Ile Ile Glu Leu  Gln Glu Ala 
    2915                 2920                 2925             


Ala Gln  Ile Asn Ala Gly Leu  Gln Pro Thr Asn Leu  Gly Arg Asn 
    2930                 2935                 2940             


Asn Ser  Leu His Asp Met Lys  Thr Val Val Lys Thr  Trp Arg Asn 
    2945                 2950                 2955             


Arg Leu  Pro Ile Val Ser Asp  Asp Leu Ser His Trp  Ser Ser Ile 
    2960                 2965                 2970             


Phe Met  Trp Arg Gln His His  Tyr Gln Ala Ile Val  Thr Ala Tyr 
    2975                 2980                 2985             


Glu Asn  Ser Ser Gln His Asp  Pro Ser Ser Asn Asn  Ala Met Leu 
    2990                 2995                 3000             


Gly Val  His Ala Ser Ala Ser  Ala Ile Ile Gln Tyr  Gly Lys Ile 
    3005                 3010                 3015             


Ala Arg  Lys Gln Gly Leu Val  Asn Val Ala Leu Asp  Ile Leu Ser 
    3020                 3025                 3030             


Arg Ile  His Thr Ile Pro Thr  Val Pro Ile Val Asp  Cys Phe Gln 
    3035                 3040                 3045             


Lys Ile  Arg Gln Gln Val Lys  Cys Tyr Leu Gln Leu  Ala Gly Val 
    3050                 3055                 3060             


Met Gly  Lys Asn Glu Cys Met  Gln Gly Leu Glu Val  Ile Glu Ser 
    3065                 3070                 3075             


Thr Asn  Leu Lys Tyr Phe Thr  Lys Glu Met Thr Ala  Glu Phe Tyr 
    3080                 3085                 3090             


Ala Leu  Lys Gly Met Phe Leu  Ala Gln Ile Asn Lys  Ser Glu Glu 
    3095                 3100                 3105             


Ala Asn  Lys Ala Phe Ser Ala  Ala Val Gln Met His  Asp Val Leu 
    3110                 3115                 3120             


Val Lys  Ala Trp Ala Met Trp  Gly Asp Tyr Leu Glu  Asn Ile Phe 
    3125                 3130                 3135             


Val Lys  Glu Arg Gln Leu His  Leu Gly Val Ser Ala  Ile Thr Cys 
    3140                 3145                 3150             


Tyr Leu  His Ala Cys Arg His  Gln Asn Glu Ser Lys  Ser Arg Lys 
    3155                 3160                 3165             


Tyr Leu  Ala Lys Val Leu Trp  Leu Leu Ser Phe Asp  Asp Asp Lys 
    3170                 3175                 3180             


Asn Thr  Leu Ala Asp Ala Val  Asp Lys Tyr Cys Ile  Gly Val Pro 
    3185                 3190                 3195             


Pro Ile  Gln Trp Leu Ala Trp  Ile Pro Gln Leu Leu  Thr Cys Leu 
    3200                 3205                 3210             


Val Gly  Ser Glu Gly Lys Leu  Leu Leu Asn Leu Ile  Ser Gln Val 
    3215                 3220                 3225             


Gly Arg  Val Tyr Pro Gln Ala  Val Tyr Phe Pro Ile  Arg Thr Leu 
    3230                 3235                 3240             


Tyr Leu  Thr Leu Lys Ile Glu  Gln Arg Glu Arg Tyr  Lys Ser Asp 
    3245                 3250                 3255             


Pro Gly  Pro Ile Arg Ala Thr  Ala Pro Met Trp Arg  Cys Ser Arg 
    3260                 3265                 3270             


Ile Met  His Met Gln Arg Glu  Leu His Pro Thr Leu  Leu Ser Ser 
    3275                 3280                 3285             


Leu Glu  Gly Ile Val Asp Gln  Met Val Trp Phe Arg  Glu Asn Trp 
    3290                 3295                 3300             


His Glu  Glu Val Leu Arg Gln  Leu Gln Gln Gly Leu  Ala Lys Cys 
    3305                 3310                 3315             


Tyr Ser  Val Ala Phe Glu Lys  Ser Gly Ala Val Ser  Asp Ala Lys 
    3320                 3325                 3330             


Ile Thr  Pro His Thr Leu Asn  Phe Val Lys Lys Leu  Val Ser Thr 
    3335                 3340                 3345             


Phe Gly  Val Gly Leu Glu Asn  Val Ser Asn Val Ser  Thr Met Phe 
    3350                 3355                 3360             


Ser Ser  Ala Ala Ser Glu Ser  Leu Ala Arg Arg Ala  Gln Ala Thr 
    3365                 3370                 3375             


Ala Gln  Asp Pro Val Phe Gln  Lys Leu Lys Gly Gln  Phe Thr Thr 
    3380                 3385                 3390             


Asp Phe  Asp Phe Ser Val Pro  Gly Ser Met Lys Leu  His Asn Leu 
    3395                 3400                 3405             


Ile Ser  Lys Leu Lys Lys Trp  Ile Lys Ile Leu Glu  Ala Lys Thr 
    3410                 3415                 3420             


Lys Gln  Leu Pro Lys Phe Phe  Leu Ile Glu Glu Lys  Cys Arg Phe 
    3425                 3430                 3435             


Leu Ser  Asn Phe Ser Ala Gln  Thr Ala Glu Val Glu  Ile Pro Gly 
    3440                 3445                 3450             


Glu Phe  Leu Met Pro Lys Pro  Thr His Tyr Tyr Ile  Lys Ile Ala 
    3455                 3460                 3465             


Arg Phe  Met Pro Arg Val Glu  Ile Val Gln Lys His  Asn Thr Ala 
    3470                 3475                 3480             


Ala Arg  Arg Leu Tyr Ile Arg  Gly His Asn Gly Lys  Ile Tyr Pro 
    3485                 3490                 3495             


Tyr Leu  Val Met Asn Asp Ala  Cys Leu Thr Glu Ser  Arg Arg Glu 
    3500                 3505                 3510             


Glu Arg  Val Leu Gln Leu Leu  Arg Leu Leu Asn Pro  Cys Leu Glu 
    3515                 3520                 3525             


Lys Arg  Lys Glu Thr Thr Lys  Arg His Leu Phe Phe  Thr Val Pro 
    3530                 3535                 3540             


Arg Val  Val Ala Val Ser Pro  Gln Met Arg Leu Val  Glu Asp Asn 
    3545                 3550                 3555             


Pro Ser  Ser Leu Ser Leu Val  Glu Ile Tyr Lys Gln  Arg Cys Ala 
    3560                 3565                 3570             


Lys Lys  Gly Ile Glu His Asp  Asn Pro Ile Ser Arg  Tyr Tyr Asp 
    3575                 3580                 3585             


Arg Leu  Ala Thr Val Gln Ala  Arg Gly Thr Gln Ala  Ser His Gln 
    3590                 3595                 3600             


Val Leu  Arg Asp Ile Leu Lys  Glu Val Gln Ser Asn  Met Val Pro 
    3605                 3610                 3615             


Arg Ser  Met Leu Lys Glu Trp  Ala Leu His Thr Phe  Pro Asn Ala 
    3620                 3625                 3630             


Thr Asp  Tyr Trp Thr Phe Arg  Lys Met Phe Thr Ile  Gln Leu Ala 
    3635                 3640                 3645             


Leu Ile  Gly Phe Ala Glu Phe  Val Leu His Leu Asn  Arg Leu Asn 
    3650                 3655                 3660             


Pro Glu  Met Leu Gln Ile Ala  Gln Asp Thr Gly Lys  Leu Asn Val 
    3665                 3670                 3675             


Ala Tyr  Phe Arg Phe Asp Ile  Asn Asp Ala Thr Gly  Asp Leu Asp 
    3680                 3685                 3690             


Ala Asn  Arg Pro Val Pro Phe  Arg Leu Thr Pro Asn  Ile Ser Glu 
    3695                 3700                 3705             


Phe Leu  Thr Thr Ile Gly Val  Ser Gly Pro Leu Thr  Ala Ser Met 
    3710                 3715                 3720             


Ile Ala  Val Ala Arg Cys Phe  Ala Gln Pro Asn Phe  Lys Val Asp 
    3725                 3730                 3735             


Gly Ile  Leu Lys Thr Val Leu  Arg Asp Glu Ile Ile  Ala Trp His 
    3740                 3745                 3750             


Lys Lys  Thr Gln Glu Asp Thr  Ser Ser Pro Leu Ser  Ala Ala Gly 
    3755                 3760                 3765             


Gln Pro  Glu Asn Met Asp Ser  Gln Gln Leu Val Ser  Leu Val Gln 
    3770                 3775                 3780             


Lys Ala  Val Thr Ala Ile Met  Thr Arg Leu His Asn  Leu Ala Gln 
    3785                 3790                 3795             


Phe Glu  Gly Gly Glu Ser Lys  Val Asn Thr Leu Val  Ala Ala Ala 
    3800                 3805                 3810             


Asn Ser  Leu Asp Asn Leu Cys  Arg Met Asp Pro Ala  Trp His Pro 
    3815                 3820                 3825             


Trp Leu  
    3830 


<210>  3
<211>  4395
<212>  DNA
<213>  Homo sapiens

<400>  3
atgggcagag tgggctattg gaccctgctg gtgctgccgg cccttctggt ctggcgcggt       60

ccggcgccga gcgcggcggc ggagaagggt ccccccgcgc taaatattgc ggtgatgctg      120

ggtcacagcc acgacgtgac agagcgcgaa cttcgaacac tgtggggccc cgagcaggcg      180

gcggggctgc ccctggacgt gaacgtggta gctctgctga tgaaccgcac cgaccccaag      240

agcctcatca cgcacgtgtg cgacctcatg tccggggcac gcatccacgg cctcgtgttt      300

ggggacgaca cggaccagga ggccgtagcc cagatgctgg attttatctc ctcccacacc      360

ttcgtcccca tcttgggcat tcatgggggc gcatctatga tcatggctga caaggatccg      420

acgtctacct tcttccagtt tggagcgtcc atccagcagc aagccacggt catgctgaag      480

atcatgcagg attatgactg gcatgtcttc tccctggtga ccactatctt ccctggctac      540

agggaattca tcagcttcgt caagaccaca gtggacaaca gctttgtggg ctgggacatg      600

cagaatgtga tcacactgga cacttccttt gaggatgcaa agacacaagt ccagctgaag      660

aagatccact cttctgtcat cttgctctac tgttccaaag acgaggctgt tctcattctg      720

agtgaggccc gctcccttgg cctcaccggg tatgatttct tctggattgt ccccagcttg      780

gtctctggga acacggagct catcccaaaa gagtttccat cgggactcat ttctgtctcc      840

tacgatgact gggactacag cctggaggcg agagtgaggg acggcattgg catcctaacc      900

accgctgcat cttctatgct ggagaagttc tcctacatcc ccgaggccaa ggccagctgc      960

tacgggcaga tggagaggcc agaggtcccg atgcacacct tgcacccatt tatggtcaat     1020

gttacatggg atggcaaaga cttatccttc actgaggaag gctaccaggt gcaccccagg     1080

ctggtggtga ttgtgctgaa caaagaccgg gaatgggaaa aggtgggcaa gtgggagaac     1140

catacgctga gcctgaggca cgccgtgtgg cccaggtaca agtccttctc cgactgtgag     1200

ccggatgaca accatctcag catcgtcacc ctggaggagg ccccattcgt catcgtggaa     1260

gacatagacc ccctgaccga gacgtgtgtg aggaacaccg tgccatgtcg gaagttcgtc     1320

aaaatcaaca attcaaccaa tgaggggatg aatgtgaaga aatgctgcaa ggggttctgc     1380

attgatattc tgaagaagct ttccagaact gtgaagttta cttacgacct ctatctggtg     1440

accaatggga agcatggcaa gaaagttaac aatgtgtgga atggaatgat cggtgaagtg     1500

gtctatcaac gggcagtcat ggcagttggc tcgctcacca tcaatgagga acgttctgaa     1560

gtggtggact tctctgtgcc ctttgtggaa acgggaatca gtgtcatggt ttcaagaagt     1620

aatggcaccg tctcaccttc tgcttttcta gaaccattca gcgcctctgt ctgggtgatg     1680

atgtttgtga tgctgctcat tgtttctgcc atagctgttt ttgtctttga atacttcagc     1740

cctgttggat acaacagaaa cttagccaaa gggaaagcac cccatgggcc ttcttttaca     1800

attggaaaag ctatatggct tctttggggc ctggtgttca ataactccgt gcctgtccag     1860

aatcctaaag ggaccaccag caagatcatg gtatctgtat gggccttctt cgctgtcata     1920

ttcctggcta gctacacagc caatctggct gccttcatga tccaagagga atttgtggac     1980

caagtgaccg gcctcagtga caaaaagttt cagagacctc atgactattc cccacctttt     2040

cgatttggga cagtgcctaa tggaagcacg gagagaaaca ttcggaataa ctatccctac     2100

atgcatcagt acatgaccaa atttaatcag aaaggagtag aggacgcctt ggtcagcctg     2160

aaaacgggga agctggacgc tttcatctac gatgccgcag tcttgaatta caaggctggg     2220

agggatgaag gctgcaagct ggtgaccatc gggagtgggt acatctttgc caccaccggt     2280

tatggaattg cccttcagaa aggctctcct tggaagaggc agatcgacct ggccttgctt     2340

cagtttgtgg gtgatggtga gatggaggag ctggagaccc tgtggctcac tgggatctgc     2400

cacaacgaga agaacgaggt gatgagcagc cagctggaca ttgacaacat ggcgggcgta     2460

ttctacatgc tggctgccgc catggccctt agcctcatca ccttcatctg ggagcacctc     2520

ttctactgga agctgcgctt ctgtttcacg ggcgtgtgct ccgaccggcc tgggttgctc     2580

ttctccatca gcaggggcat ctacagctgc attcatggag tgcacattga agaaaagaag     2640

aagtctccag acttcaatct gacgggatcc cagagcaaca tgttaaaact cctccggtca     2700

gccaaaaaca tttccagcat gtccaacatg aactcctcaa gaatggactc acccaaaaga     2760

gctgctgact tcatccaaag aggttccctc atcatggaca tggtttcaga taaggggaat     2820

ttgatgtact cagacaacag gtcctttcag gggaaagaga gcatttttgg agacaacatg     2880

aacgaactcc aaacatttgt ggccaaccgg cagaaggata acctcaataa ctatgtattc     2940

cagggacaac atcctcttac tctcaatgag tccaacccta acacggtgga ggtggccgtg     3000

agcacagaat ccaaagcgaa ctctagaccc cggcagctgt ggaagaaatc cgtggattcc     3060

atacgccagg attcactatc ccagaatcca gtctcccaga gggatgaggc aacagcagag     3120

aataggaccc actccctaaa gagccctagg tatcttccag aagagatggc ccactctgac     3180

atttcagaaa cgtcaaatcg ggccacgtgc cacagggaac ctgacaacag taagaaccac     3240

aaaaccaagg acaactttaa aaggtcagtg gcctccaaat accccaagga ctgtagtgag     3300

gtcgagcgca cctacctgaa aaccaaatca agctccccta gagacaagat ctacactata     3360

gatggtgaga aggagcctgg tttccactta gatccacccc agtttgttga aaatgtgacc     3420

ctgcccgaga acgtggactt cccggacccc taccaggatc ccagtgaaaa cttccgcaag     3480

ggggactcca cgctgccaat gaaccggaac cccttgcata atgaagaggg gctttccaac     3540

aacgaccagt ataaactcta ctccaagcac ttcaccttga aagacaaggg ttccccgcac     3600

agtgagacca gcgagcgata ccggcagaac tccacgcact gcagaagctg cctttccaac     3660

atgcccacct attcaggcca cttcaccatg aggtccccct tcaagtgcga tgcctgcctg     3720

cggatgggga acctctatga catcgatgaa gaccagatgc ttcaggagac aggtaaccca     3780

gccaccgggg agcaggtcta ccagcaggac tgggcacaga acaatgccct tcaattacaa     3840

aagaacaagc taaggattag ccgtcagcat tcctacgata acattgtcga caaacctagg     3900

gagctagacc ttagcaggcc ctcccggagc ataagcctca aggacaggga acggcttctg     3960

gagggaaatt tttacggcag cctgtttagt gtcccctcaa gcaaactctc ggggaaaaaa     4020

agctcccttt tcccccaagg tctggaggac agcaagagga gcaagtctct cttgccagac     4080

cacacctccg ataacccttt cctccactcc cacagggatg accaacgctt ggttattggg     4140

agatgcccct cggaccctta caaacactcg ttgccatccc aggcggtgaa tgacagctat     4200

cttcggtcgt ccttgaggtc aacggcatcg tactgttcca gggacagtcg gggccacaat     4260

gatgtgtata tttcggagca tgttatgcct tatgctgcaa ataagaataa tatgtactct     4320

acccccaggg ttttaaattc ctgcagcaat agacgcgtgt acaagaaaat gcctagtatc     4380

gaatctgatg tttaa                                                      4395


<210>  4
<211>  1464
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu 
1               5                   10                  15      


Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro 
            20                  25                  30          


Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu 
        35                  40                  45              


Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro 
    50                  55                  60                  


Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys 
65                  70                  75                  80  


Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His 
                85                  90                  95      


Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met 
            100                 105                 110         


Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His 
        115                 120                 125             


Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe 
    130                 135                 140                 


Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys 
145                 150                 155                 160 


Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile 
                165                 170                 175     


Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp 
            180                 185                 190         


Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr 
        195                 200                 205             


Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser 
    210                 215                 220                 


Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu 
225                 230                 235                 240 


Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile 
                245                 250                 255     


Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe 
            260                 265                 270         


Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu 
        275                 280                 285             


Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser 
    290                 295                 300                 


Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys 
305                 310                 315                 320 


Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro 
                325                 330                 335     


Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu 
            340                 345                 350         


Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys 
        355                 360                 365             


Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser 
    370                 375                 380                 


Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu 
385                 390                 395                 400 


Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu 
        435                 440                 445             


Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu 
    450                 455                 460                 


Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val 
465                 470                 475                 480 


Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met 
                485                 490                 495     


Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu 
            500                 505                 510         


Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe 
        515                 520                 525             


Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val 
    530                 535                 540                 


Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met 
545                 550                 555                 560 


Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Phe Val Phe 
                565                 570                 575     


Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys 
            580                 585                 590         


Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu 
        595                 600                 605             


Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly 
    610                 615                 620                 


Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile 
625                 630                 635                 640 


Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu 
                645                 650                 655     


Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg 
            660                 665                 670         


Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly 
        675                 680                 685             


Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr 
    690                 695                 700                 


Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu 
705                 710                 715                 720 


Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn 
                725                 730                 735     


Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser 
            740                 745                 750         


Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly 
        755                 760                 765             


Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly 
    770                 775                 780                 


Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys 
785                 790                 795                 800 


His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn 
                805                 810                 815     


Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu 
            820                 825                 830         


Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys 
        835                 840                 845             


Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser 
    850                 855                 860                 


Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys 
865                 870                 875                 880 


Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys 
                885                 890                 895     


Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser 
            900                 905                 910         


Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly 
        915                 920                 925             


Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser 
    930                 935                 940                 


Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met 
945                 950                 955                 960 


Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn 
                965                 970                 975     


Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn 
            980                 985                 990         


Pro Asn Thr Val Glu Val Ala Val  Ser Thr Glu Ser Lys  Ala Asn Ser 
        995                 1000                 1005             


Arg Pro  Arg Gln Leu Trp Lys  Lys Ser Val Asp Ser  Ile Arg Gln 
    1010                 1015                 1020             


Asp Ser  Leu Ser Gln Asn Pro  Val Ser Gln Arg Asp  Glu Ala Thr 
    1025                 1030                 1035             


Ala Glu  Asn Arg Thr His Ser  Leu Lys Ser Pro Arg  Tyr Leu Pro 
    1040                 1045                 1050             


Glu Glu  Met Ala His Ser Asp  Ile Ser Glu Thr Ser  Asn Arg Ala 
    1055                 1060                 1065             


Thr Cys  His Arg Glu Pro Asp  Asn Ser Lys Asn His  Lys Thr Lys 
    1070                 1075                 1080             


Asp Asn  Phe Lys Arg Ser Val  Ala Ser Lys Tyr Pro  Lys Asp Cys 
    1085                 1090                 1095             


Ser Glu  Val Glu Arg Thr Tyr  Leu Lys Thr Lys Ser  Ser Ser Pro 
    1100                 1105                 1110             


Arg Asp  Lys Ile Tyr Thr Ile  Asp Gly Glu Lys Glu  Pro Gly Phe 
    1115                 1120                 1125             


His Leu  Asp Pro Pro Gln Phe  Val Glu Asn Val Thr  Leu Pro Glu 
    1130                 1135                 1140             


Asn Val  Asp Phe Pro Asp Pro  Tyr Gln Asp Pro Ser  Glu Asn Phe 
    1145                 1150                 1155             


Arg Lys  Gly Asp Ser Thr Leu  Pro Met Asn Arg Asn  Pro Leu His 
    1160                 1165                 1170             


Asn Glu  Glu Gly Leu Ser Asn  Asn Asp Gln Tyr Lys  Leu Tyr Ser 
    1175                 1180                 1185             


Lys His  Phe Thr Leu Lys Asp  Lys Gly Ser Pro His  Ser Glu Thr 
    1190                 1195                 1200             


Ser Glu  Arg Tyr Arg Gln Asn  Ser Thr His Cys Arg  Ser Cys Leu 
    1205                 1210                 1215             


Ser Asn  Met Pro Thr Tyr Ser  Gly His Phe Thr Met  Arg Ser Pro 
    1220                 1225                 1230             


Phe Lys  Cys Asp Ala Cys Leu  Arg Met Gly Asn Leu  Tyr Asp Ile 
    1235                 1240                 1245             


Asp Glu  Asp Gln Met Leu Gln  Glu Thr Gly Asn Pro  Ala Thr Gly 
    1250                 1255                 1260             


Glu Gln  Val Tyr Gln Gln Asp  Trp Ala Gln Asn Asn  Ala Leu Gln 
    1265                 1270                 1275             


Leu Gln  Lys Asn Lys Leu Arg  Ile Ser Arg Gln His  Ser Tyr Asp 
    1280                 1285                 1290             


Asn Ile  Val Asp Lys Pro Arg  Glu Leu Asp Leu Ser  Arg Pro Ser 
    1295                 1300                 1305             


Arg Ser  Ile Ser Leu Lys Asp  Arg Glu Arg Leu Leu  Glu Gly Asn 
    1310                 1315                 1320             


Phe Tyr  Gly Ser Leu Phe Ser  Val Pro Ser Ser Lys  Leu Ser Gly 
    1325                 1330                 1335             


Lys Lys  Ser Ser Leu Phe Pro  Gln Gly Leu Glu Asp  Ser Lys Arg 
    1340                 1345                 1350             


Ser Lys  Ser Leu Leu Pro Asp  His Thr Ser Asp Asn  Pro Phe Leu 
    1355                 1360                 1365             


His Ser  His Arg Asp Asp Gln  Arg Leu Val Ile Gly  Arg Cys Pro 
    1370                 1375                 1380             


Ser Asp  Pro Tyr Lys His Ser  Leu Pro Ser Gln Ala  Val Asn Asp 
    1385                 1390                 1395             


Ser Tyr  Leu Arg Ser Ser Leu  Arg Ser Thr Ala Ser  Tyr Cys Ser 
    1400                 1405                 1410             


Arg Asp  Ser Arg Gly His Asn  Asp Val Tyr Ile Ser  Glu His Val 
    1415                 1420                 1425             


Met Pro  Tyr Ala Ala Asn Lys  Asn Asn Met Tyr Ser  Thr Pro Arg 
    1430                 1435                 1440             


Val Leu  Asn Ser Cys Ser Asn  Arg Arg Val Tyr Lys  Lys Met Pro 
    1445                 1450                 1455             


Ser Ile  Glu Ser Asp Val 
    1460                 


<210>  5
<211>  11
<212>  DNA
<213>  Homo sapiens

<400>  5
tgtctccctc t                                                            11


<210>  6
<211>  11
<212>  DNA
<213>  Homo sapiens

<400>  6
tgtctycctc t                                                            11


<210>  7
<211>  11
<212>  DNA
<213>  Homo sapiens

<400>  7
tgtctyyctc t                                                            11


<210>  8
<211>  51
<212>  PRT
<213>  Canis familiaris

<400>  8

Leu Pro Glu Met Gly Ser His Val Glu Leu Ser Asn Leu Tyr Leu Lys 
1               5                   10                  15      


Leu Phe Lys Leu Val Phe Gly Ser Val Ser Leu Phe Ala Ala Glu Asn 
            20                  25                  30          


Glu Gln Met Leu Lys Pro His Leu His Lys Ile Val Asn Ser Ser Met 
        35                  40                  45              


Glu Leu Ala 
    50      


<210>  9
<211>  51
<212>  PRT
<213>  Pan troglodytes

<400>  9

Leu Pro Glu Met Gly Ser Asn Val Glu Leu Ser Asn Leu Tyr Leu Lys 
1               5                   10                  15      


Leu Phe Lys Leu Val Phe Gly Ser Val Ser Leu Phe Ala Ala Glu Asn 
            20                  25                  30          


Glu Gln Met Leu Lys Pro His Leu His Lys Ile Val Asn Ser Ser Met 
        35                  40                  45              


Glu Leu Ala 
    50      


<210>  10
<211>  51
<212>  PRT
<213>  Bos taurus

<400>  10

Leu Pro Glu Met Gly Ser Asn Val Glu Leu Ser Asn Leu Tyr Leu Lys 
1               5                   10                  15      


Leu Phe Lys Leu Val Phe Gly Ser Val Ser Leu Phe Ala Ala Glu Asn 
            20                  25                  30          


Glu Gln Met Leu Lys Pro His Leu His Lys Ile Val Asn Ser Ser Met 
        35                  40                  45              


Glu Leu Ala 
    50      


<210>  11
<211>  51
<212>  PRT
<213>  Rattus norvegicus

<400>  11

Leu Pro Glu Met Gly Ser Asn Val Glu Leu Ser Asn Leu Tyr Leu Lys 
1               5                   10                  15      


Leu Phe Lys Leu Val Phe Gly Ser Val Ser Leu Phe Ala Ala Glu Asn 
            20                  25                  30          


Glu Gln Met Leu Lys Pro His Leu His Lys Ile Val Asn Ser Ser Met 
        35                  40                  45              


Glu Leu Ala 
    50      


<210>  12
<211>  51
<212>  PRT
<213>  Gallus gallus

<400>  12

Leu Pro Glu Met Gly Ser Asn Val Glu Leu Ser Asn Leu Tyr Leu Lys 
1               5                   10                  15      


Leu Phe Lys Leu Val Phe Gly Ser Val Ser Leu Phe Ala Ala Glu Asn 
            20                  25                  30          


Glu Gln Met Leu Lys Pro His Leu His Lys Ile Val Asn Ser Ser Met 
        35                  40                  45              


Glu Leu Ala 
    50      


<210>  13
<211>  51
<212>  PRT
<213>  Danio rerio

<400>  13

Leu Pro Glu Met Gly Ser Asn Val Glu Leu Ser Asn Leu Tyr Leu Lys 
1               5                   10                  15      


Leu Phe Lys Leu Val Phe Gly Ser Val Ser Leu Phe Ala Ala Glu Asn 
            20                  25                  30          


Glu Gln Met Leu Lys Pro His Leu His Lys Ile Val Asn Ser Ser Met 
        35                  40                  45              


Glu Leu Ala 
    50      


<210>  14
<211>  51
<212>  PRT
<213>  Mus musculus

<400>  14

Leu Pro Glu Met Gly Ser Asn Val Glu Leu Ser Asn Leu Tyr Leu Lys 
1               5                   10                  15      


Leu Phe Lys Leu Val Phe Gly Ser Val Ser Leu Phe Ala Ala Glu Asn 
            20                  25                  30          


Glu Gln Met Leu Lys Pro His Leu His Lys Ile Val Asn Ser Ser Met 
        35                  40                  45              


Glu Leu Ala 
    50      


<210>  15
<211>  51
<212>  PRT
<213>  Drosophila melanogaster

<400>  15

Met Glu Glu Met Gly Ser Asn Leu Glu Arg Ser Asn Leu Tyr Leu Arg 
1               5                   10                  15      


Leu Phe Lys Leu Val Phe Gly Ser Val Ser Leu Phe Pro Val Glu Asn 
            20                  25                  30          


Glu Gln Met Leu Arg Pro His Leu His Lys Ile Val Asn Arg Ser Met 
        35                  40                  45              


Glu Leu Ala 
    50      


<210>  16
<211>  51
<212>  PRT
<213>  Anopheles gambiae

<400>  16

Met Asp Glu Met Gly Ser Asn Ile Glu Arg Ser Asn Leu Tyr Leu Arg 
1               5                   10                  15      


Leu Phe Lys Leu Val Phe Gly Ser Val Ser Leu Phe Ala Ala Glu Asn 
            20                  25                  30          


Glu His Met Leu Arg Pro His Leu His Asn Ile Val Asn Arg Ser Met 
        35                  40                  45              


Glu Leu Ala 
    50      


<210>  17
<211>  53
<212>  PRT
<213>  Caenorhabditis elegans

<400>  17

Met Lys Leu Leu Glu Val Ser Asn Asp Lys Thr Met Leu Tyr Val Lys 
1               5                   10                  15      


Leu Phe Lys Ile Ile Phe Ser Ala Ile Gly Ala Asn Gly Ser Gly Leu 
            20                  25                  30          


His Gly Asp Lys Met Leu Thr Ser Tyr Leu Pro Glu Ile Leu Lys Gln 
        35                  40                  45              


Ser Thr Val Leu Ala 
    50              


<210>  18
<211>  52
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  18

Leu Lys Asp Leu Gly Asn Val Asp Phe Asn Thr Ser Asn Val Leu Ile 
1               5                   10                  15      


Arg Leu Phe Lys Leu Ser Phe Met Ser Val Asn Leu Phe Pro Asn Ile 
            20                  25                  30          


Asn Glu Val Val Leu Leu Pro His Leu Asn Asp Leu Ile Leu Asn Ser 
        35                  40                  45              


Leu Lys Tyr Ser 
    50          


<210>  19
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  19
gtaaaacgac ggccagttaa aactgctttg gggaagg                                37


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  20
gagtgcctat agtcccaaaa a                                                 21


<210>  21
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  21
gtaaaacgac ggccagt                                                      17


<210>  22
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
gtaaaacgac ggccagtttg ctacgattct ggtggaa                                37


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  23
cgtgaggccc tgtctctaac                                                   20


<210>  24
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
gtaaaacgac ggccagt                                                      17


<210>  25
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  25
gtaaaacgac ggccagtcct atcctgctgc tgagttcc                               38


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
agtttccggc cttaccttgt c                                                 21


<210>  27
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  27
gtaaaacgac ggccagtaga gtgggctatt ggaccctg                               38


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  28
gaggcaagac ctggttctca c                                                 21


<210>  29
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  29
gtaaaacgac ggccagtcta ggacgcagtt tgtgcttc                               38


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  30
gaacagcctc gtctttggaa c                                                 21


<210>  31
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  31
gtaaaacgac ggccagtggc tacagggaat tcatcagc                               38


<210>  32
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  32
tcagtgcgta tttccaacaa tg                                                22


<210>  33
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  33
gtaaaacgac ggccagtgca gagaggcttc ttgtgatg                               38


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  34
agaaagaagc actgtgagcc c                                                 21


<210>  35
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  35
gtaaaacgac ggccagtgga aaggatttgc ctctccag                               38


<210>  36
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  36
gcaagtgtgg cacatctcta gg                                                22


<210>  37
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  37
gtaaaacgac ggccagtgtc cttgggaaag ccacttc                                37


<210>  38
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  38
cgttgataga ccacctggat g                                                 21


<210>  39
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  39
gtaaaacgac ggccagtatg tctgggcttc ctgctg                                 36


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  40
tcctgacctc atgatccacc                                                   20


<210>  41
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  41
gtaaaacgac ggccagtttc catcttctgg caaccttc                               38


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  42
tcaatgagag gcacctgaat c                                                 21


<210>  43
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  43
gtaaaacgac ggccagtttg tcatcctgcc ctaatgc                                37


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  44
catgccgaga gtcaatttct g                                                 21


<210>  45
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  45
gtaaaacgac ggccagtaaa gtgtgggatg ctttcagg                               38


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  46
atgcaaagat ccactgggaa g                                                 21


<210>  47
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  47
gtaaaacgac ggccagtgtc tgttccaaac ccagaagc                               38


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  48
tgagacatca agaacccaag c                                                 21


<210>  49
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  49
gtaaaacgac ggccagtccc tatgctttgc aacttgtc                               38


<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  50
gaaaccatgt ccatgatgag g                                                 21


<210>  51
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  51
gtaaaacgac ggccagtcag gcatctacag ctgcattc                               38


<210>  52
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  52
ggagtgggtc ctattctctg c                                                 21


<210>  53
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  53
gtaaaacgac ggccagtaga caacaggtcc tttcaggg                               38


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  54
tgttgtcagg ttccctgtgg                                                   20


<210>  55
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  55
gtaaaacgac ggccagtatt ccatacgcca ggattcac                               38


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  56
gtatcgctcg ctggtctcac                                                   20


<210>  57
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  57
gtaaaacgac ggccagtaac gtggacttcc cggac                                  35


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  58
gcccagtcct gctggtagac                                                   20


<210>  59
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  59
gtaaaacgac ggccagtgtg agaccagcga gcgatac                                37


<210>  60
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  60
gaaagggtta tcggaggtgt g                                                 21


<210>  61
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  61
gtaaaacgac ggccagtgct agaccttagc aggccctc                               38


<210>  62
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  62
tttaccctcc agaacattgg c                                                 21


<210>  63
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  63
cagatggtga aaggaatgct c                                                 21


<210>  64
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  64
gcaaagagga agacagagcc aaag                                              24


<210>  65
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  65
ctttggctct gtcttcctct ttgc                                              24


<210>  66
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  66
gttcataaca acatgcacac ag                                                22


<210>  67
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  67
ccggcgtgta agaaagggag aatatctcga gatattctcc ctttcttaca cgttttt          57


<210>  68
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  68
cgtgtaagaa agggagaata t                                                 21


<210>  69
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  69
atattctccc tttcttacac g                                                 21


<210>  70
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  70
ccgggccctg ttctttcgct ttgtactcga gtacaaagcg aaagaacagg gcttttt          57


<210>  71
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  71
gccctgttct ttcgctttgt a                                                 21


<210>  72
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  72
tacaaagcga aagaacaggg c                                                 21


