                         SEQUENCE LISTING

<110>  MUELLER, Christopher
       DUHERON, Vincent
       IFOR, Williams
 
<120>  MODULATION DE LA PROLIFERATION DES CELLULES EPITHELIALES DE 
       L'UNITE EPIDERMO-PILO-SEBACEE VIA RANK

<130>  BIP208883FR00

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce

<400>  1
ccaagtagtg gattctaaat cctg                                              24


<210>  2
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce

<400>  2
ggttggacac ctgaatgcta atttc                                             25


<210>  3
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce

<400>  3
attcgcagcg catcccttct atcg                                              24


<210>  4
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce

<400>  4
atggactaca aagacgatga cgaca                                             25


<210>  5
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce

<400>  5
tgccaggaat ccaccgccac cag                                               23


<210>  6
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce

<400>  6
tgcgtgctgc tcgttcca                                                     18


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce

<400>  7
tgccaggatc caccgccacc ag                                                22


<210>  8
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce

<400>  8
agcatcgctc tgttcctgt                                                    19


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce

<400>  9
tcgtgctccc tcctttcatc                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce

<400>  10
cagcatcgct ctgttcctgt                                                   20


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce

<400>  11
gcagtgagtg ctgtcttctg a                                                 21


<210>  12
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce

<400>  12
tcgagcgcag atggatccta acagaa                                            26


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce

<400>  13
tgatgagttg tgtattgcag c                                                 21


<210>  14
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce

<400>  14
tcttacactc tcggcattc                                                    19


<210>  15
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce

<400>  15
cgaggaccac aatgaacaag tg                                                22


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce

<400>  16
tgggttgtcc attcaatgag t                                                 21


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce

<400>  17
ctgtgctgcg cactcctgtg ct                                                22


<210>  18
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce

<400>  18
tccatgacaa ctttggtatc gtgg                                              24


<210>  19
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  amorce

<400>  19
gtcgctgttg aagtcagagg agac                                              24


<210>  20
<211>  2135
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Construction RANK-Tg de souris


<220>
<221>  CDS
<222>  (264)..(2135)

<400>  20
tacgggcccc cgtgtgtgtg cacatgtctc tgtgtgaatg gacccttccc cttcccacac       60

gtgtatccct atcatcccac ccttcccacc agaggccata gccatctgct ggtttggtta      120

tttgagagtg caggccagga caaggccatc gcttggggca tgaatcctct gcgtactgcc      180

ctggccagat gcaaattccc tgccatggga ttccccagaa ggttctgttt ttcaggtggg      240

gcaagttccg tgggcgatcc acc atg tct gca ctt ctg atc cta gct ctt gtt      293
                          Met Ser Ala Leu Leu Ile Leu Ala Leu Val         
                          1               5                   10          

gga gct gca gtt gct gac tac aaa gac gat gac gac aag ctc gcg gcc        341
Gly Ala Ala Val Ala Asp Tyr Lys Asp Asp Asp Asp Lys Leu Ala Ala           
                15                  20                  25                

gcg cag gtc act cct cca tgc acc cag gag agg cat tat gag cat ctc        389
Ala Gln Val Thr Pro Pro Cys Thr Gln Glu Arg His Tyr Glu His Leu           
            30                  35                  40                    

gga cgg tgt tgc agc aga tgc gaa cca gga aag tac ctg tcc tct aag        437
Gly Arg Cys Cys Ser Arg Cys Glu Pro Gly Lys Tyr Leu Ser Ser Lys           
        45                  50                  55                        

tgc act cct acc tcc gac agt gtg tgt ctg ccc tgt ggc ccc gat gag        485
Cys Thr Pro Thr Ser Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu           
    60                  65                  70                            

tac ttg gac acc tgg aat gaa gaa gat aaa tgc ttg ctg cat aaa gtc        533
Tyr Leu Asp Thr Trp Asn Glu Glu Asp Lys Cys Leu Leu His Lys Val           
75                  80                  85                  90            

tgt gat gca ggc aag gcc ctg gtg gcg gtg gat cct ggc aac cac acg        581
Cys Asp Ala Gly Lys Ala Leu Val Ala Val Asp Pro Gly Asn His Thr           
                95                  100                 105               

gcc ccg cgt cgc tgt gct tgc acg gct ggc tac cac tgg aac tca gac        629
Ala Pro Arg Arg Cys Ala Cys Thr Ala Gly Tyr His Trp Asn Ser Asp           
            110                 115                 120                   

tgc gag tgc tgc cgc agg aac acg gag tgt gca cct ggc ttc gga gct        677
Cys Glu Cys Cys Arg Arg Asn Thr Glu Cys Ala Pro Gly Phe Gly Ala           
        125                 130                 135                       

cag cat ccc ttg cag ctc aac aag gat acg gtg tgc aca ccc tgc ctc        725
Gln His Pro Leu Gln Leu Asn Lys Asp Thr Val Cys Thr Pro Cys Leu           
    140                 145                 150                           

ctg ggc ttc ttc tca gat gtc ttt tcg tcc aca gac aaa tgc aaa cct        773
Leu Gly Phe Phe Ser Asp Val Phe Ser Ser Thr Asp Lys Cys Lys Pro           
155                 160                 165                 170           

tgg acc aac tgc acc ctc ctt gga aag cta gaa gca cac cag ggg aca        821
Trp Thr Asn Cys Thr Leu Leu Gly Lys Leu Glu Ala His Gln Gly Thr           
                175                 180                 185               

acg gaa tca gat gtg gtc tgc agc tct tcc atg aca ctg agg aga cca        869
Thr Glu Ser Asp Val Val Cys Ser Ser Ser Met Thr Leu Arg Arg Pro           
            190                 195                 200                   

ccc aag gag gcc cag gct tac ctg ccc agt ctc atc gtt ctg ctc ctc        917
Pro Lys Glu Ala Gln Ala Tyr Leu Pro Ser Leu Ile Val Leu Leu Leu           
        205                 210                 215                       

ttc atc tct gtg gta gta gtg gct gcc atc atc ttc ggc gtt tac tac        965
Phe Ile Ser Val Val Val Val Ala Ala Ile Ile Phe Gly Val Tyr Tyr           
    220                 225                 230                           

agg aag gga ggg aaa gcg ctg aca gct aat ttg tgg aat tgg gtc aat       1013
Arg Lys Gly Gly Lys Ala Leu Thr Ala Asn Leu Trp Asn Trp Val Asn           
235                 240                 245                 250           

gat gct tgc agt agt cta agt gga aat aag gag tcc tca ggg gac cgt       1061
Asp Ala Cys Ser Ser Leu Ser Gly Asn Lys Glu Ser Ser Gly Asp Arg           
                255                 260                 265               

tgt gct ggt tcc cac tcg gca acc tcc agt cag caa gaa gtg tgt gaa       1109
Cys Ala Gly Ser His Ser Ala Thr Ser Ser Gln Gln Glu Val Cys Glu           
            270                 275                 280                   

ggt atc tta cta atg act cgg gag gag aag atg gtt cca gaa gac ggt       1157
Gly Ile Leu Leu Met Thr Arg Glu Glu Lys Met Val Pro Glu Asp Gly           
        285                 290                 295                       

gct gga gtc tgt ggg cct gtg tgt gcg gca ggt ggg ccc tgg gca gaa       1205
Ala Gly Val Cys Gly Pro Val Cys Ala Ala Gly Gly Pro Trp Ala Glu           
    300                 305                 310                           

gtc aga gat tct agg acg ttc aca ctg gtc agc gag gtt gag acg caa       1253
Val Arg Asp Ser Arg Thr Phe Thr Leu Val Ser Glu Val Glu Thr Gln           
315                 320                 325                 330           

gga gac ctc tcg agg aag att ccc aca gag gat gag tac acg gac cgg       1301
Gly Asp Leu Ser Arg Lys Ile Pro Thr Glu Asp Glu Tyr Thr Asp Arg           
                335                 340                 345               

ccc tcg cag cct tcg act ggt tca ctg ctc cta atc cag cag gga agc       1349
Pro Ser Gln Pro Ser Thr Gly Ser Leu Leu Leu Ile Gln Gln Gly Ser           
            350                 355                 360                   

aaa tct ata ccc cca ttc cag gag ccc ctg gaa gtg ggg gag aac gac       1397
Lys Ser Ile Pro Pro Phe Gln Glu Pro Leu Glu Val Gly Glu Asn Asp           
        365                 370                 375                       

agt tta agc cag tgt ttc acc ggg act gaa agc acg gtg gat tct gag       1445
Ser Leu Ser Gln Cys Phe Thr Gly Thr Glu Ser Thr Val Asp Ser Glu           
    380                 385                 390                           

ggc tgt gac ttc act gag cct ccg agc aga act gac tct atg ccc gtg       1493
Gly Cys Asp Phe Thr Glu Pro Pro Ser Arg Thr Asp Ser Met Pro Val           
395                 400                 405                 410           

tcc cct gaa aag cac ctg aca aaa gaa ata gaa ggt gac agt tgc ctc       1541
Ser Pro Glu Lys His Leu Thr Lys Glu Ile Glu Gly Asp Ser Cys Leu           
                415                 420                 425               

ccc tgg gtg gtc agc tcc aac tca aca gat ggc tac aca ggc agt ggg       1589
Pro Trp Val Val Ser Ser Asn Ser Thr Asp Gly Tyr Thr Gly Ser Gly           
            430                 435                 440                   

aac act cct ggg gag gac cat gaa ccc ttt cca ggg tcc ctg aaa tgt       1637
Asn Thr Pro Gly Glu Asp His Glu Pro Phe Pro Gly Ser Leu Lys Cys           
        445                 450                 455                       

gga cca ttg ccc cag tgt gcc tac agc atg ggc ttt ccc agt gaa gca       1685
Gly Pro Leu Pro Gln Cys Ala Tyr Ser Met Gly Phe Pro Ser Glu Ala           
    460                 465                 470                           

gca gcc agc atg gca gag gcg gga gta cgg ccc cag gac agg gct gat       1733
Ala Ala Ser Met Ala Glu Ala Gly Val Arg Pro Gln Asp Arg Ala Asp           
475                 480                 485                 490           

gag aag gga gcc tca ggg tcc ggg agc tcc ccc agt gac cag cca cct       1781
Glu Lys Gly Ala Ser Gly Ser Gly Ser Ser Pro Ser Asp Gln Pro Pro           
                495                 500                 505               

gcc tct ggg aac gtg act gga aac agt aac tcc acg ttc atc tct agc       1829
Ala Ser Gly Asn Val Thr Gly Asn Ser Asn Ser Thr Phe Ile Ser Ser           
            510                 515                 520                   

ggg cag gtg atg aac ttc aag ggt gac atc atc gtg gtg tat gtc agc       1877
Gly Gln Val Met Asn Phe Lys Gly Asp Ile Ile Val Val Tyr Val Ser           
        525                 530                 535                       

cag acc tcg cag gag ggc ccg ggt tcc gca gag ccc gag tcg gag ccc       1925
Gln Thr Ser Gln Glu Gly Pro Gly Ser Ala Glu Pro Glu Ser Glu Pro           
    540                 545                 550                           

gtg ggc cgc cct gtg cag gag gag acg ctg gca cac aga gac tcc ttt       1973
Val Gly Arg Pro Val Gln Glu Glu Thr Leu Ala His Arg Asp Ser Phe           
555                 560                 565                 570           

gcg ggc acc gcg ccg cgc ttc ccc gac gtc tgt gcc acc ggg gct ggg       2021
Ala Gly Thr Ala Pro Arg Phe Pro Asp Val Cys Ala Thr Gly Ala Gly           
                575                 580                 585               

ctg cag gag cag ggg gca ccc cgg cag aag gac ggg aca tcg cgg ccg       2069
Leu Gln Glu Gln Gly Ala Pro Arg Gln Lys Asp Gly Thr Ser Arg Pro           
            590                 595                 600                   

gtg cag gag cag ggt ggg gcg cag act tca ctc cat acc cag ggg tcc       2117
Val Gln Glu Gln Gly Gly Ala Gln Thr Ser Leu His Thr Gln Gly Ser           
        605                 610                 615                       

gga caa tgt gca gaa tga                                               2135
Gly Gln Cys Ala Glu                                                       
    620                                                                   


<210>  21
<211>  623
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  21

Met Ser Ala Leu Leu Ile Leu Ala Leu Val Gly Ala Ala Val Ala Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Leu Ala Ala Ala Gln Val Thr Pro Pro 
            20                  25                  30          


Cys Thr Gln Glu Arg His Tyr Glu His Leu Gly Arg Cys Cys Ser Arg 
        35                  40                  45              


Cys Glu Pro Gly Lys Tyr Leu Ser Ser Lys Cys Thr Pro Thr Ser Asp 
    50                  55                  60                  


Ser Val Cys Leu Pro Cys Gly Pro Asp Glu Tyr Leu Asp Thr Trp Asn 
65                  70                  75                  80  


Glu Glu Asp Lys Cys Leu Leu His Lys Val Cys Asp Ala Gly Lys Ala 
                85                  90                  95      


Leu Val Ala Val Asp Pro Gly Asn His Thr Ala Pro Arg Arg Cys Ala 
            100                 105                 110         


Cys Thr Ala Gly Tyr His Trp Asn Ser Asp Cys Glu Cys Cys Arg Arg 
        115                 120                 125             


Asn Thr Glu Cys Ala Pro Gly Phe Gly Ala Gln His Pro Leu Gln Leu 
    130                 135                 140                 


Asn Lys Asp Thr Val Cys Thr Pro Cys Leu Leu Gly Phe Phe Ser Asp 
145                 150                 155                 160 


Val Phe Ser Ser Thr Asp Lys Cys Lys Pro Trp Thr Asn Cys Thr Leu 
                165                 170                 175     


Leu Gly Lys Leu Glu Ala His Gln Gly Thr Thr Glu Ser Asp Val Val 
            180                 185                 190         


Cys Ser Ser Ser Met Thr Leu Arg Arg Pro Pro Lys Glu Ala Gln Ala 
        195                 200                 205             


Tyr Leu Pro Ser Leu Ile Val Leu Leu Leu Phe Ile Ser Val Val Val 
    210                 215                 220                 


Val Ala Ala Ile Ile Phe Gly Val Tyr Tyr Arg Lys Gly Gly Lys Ala 
225                 230                 235                 240 


Leu Thr Ala Asn Leu Trp Asn Trp Val Asn Asp Ala Cys Ser Ser Leu 
                245                 250                 255     


Ser Gly Asn Lys Glu Ser Ser Gly Asp Arg Cys Ala Gly Ser His Ser 
            260                 265                 270         


Ala Thr Ser Ser Gln Gln Glu Val Cys Glu Gly Ile Leu Leu Met Thr 
        275                 280                 285             


Arg Glu Glu Lys Met Val Pro Glu Asp Gly Ala Gly Val Cys Gly Pro 
    290                 295                 300                 


Val Cys Ala Ala Gly Gly Pro Trp Ala Glu Val Arg Asp Ser Arg Thr 
305                 310                 315                 320 


Phe Thr Leu Val Ser Glu Val Glu Thr Gln Gly Asp Leu Ser Arg Lys 
                325                 330                 335     


Ile Pro Thr Glu Asp Glu Tyr Thr Asp Arg Pro Ser Gln Pro Ser Thr 
            340                 345                 350         


Gly Ser Leu Leu Leu Ile Gln Gln Gly Ser Lys Ser Ile Pro Pro Phe 
        355                 360                 365             


Gln Glu Pro Leu Glu Val Gly Glu Asn Asp Ser Leu Ser Gln Cys Phe 
    370                 375                 380                 


Thr Gly Thr Glu Ser Thr Val Asp Ser Glu Gly Cys Asp Phe Thr Glu 
385                 390                 395                 400 


Pro Pro Ser Arg Thr Asp Ser Met Pro Val Ser Pro Glu Lys His Leu 
                405                 410                 415     


Thr Lys Glu Ile Glu Gly Asp Ser Cys Leu Pro Trp Val Val Ser Ser 
            420                 425                 430         


Asn Ser Thr Asp Gly Tyr Thr Gly Ser Gly Asn Thr Pro Gly Glu Asp 
        435                 440                 445             


His Glu Pro Phe Pro Gly Ser Leu Lys Cys Gly Pro Leu Pro Gln Cys 
    450                 455                 460                 


Ala Tyr Ser Met Gly Phe Pro Ser Glu Ala Ala Ala Ser Met Ala Glu 
465                 470                 475                 480 


Ala Gly Val Arg Pro Gln Asp Arg Ala Asp Glu Lys Gly Ala Ser Gly 
                485                 490                 495     


Ser Gly Ser Ser Pro Ser Asp Gln Pro Pro Ala Ser Gly Asn Val Thr 
            500                 505                 510         


Gly Asn Ser Asn Ser Thr Phe Ile Ser Ser Gly Gln Val Met Asn Phe 
        515                 520                 525             


Lys Gly Asp Ile Ile Val Val Tyr Val Ser Gln Thr Ser Gln Glu Gly 
    530                 535                 540                 


Pro Gly Ser Ala Glu Pro Glu Ser Glu Pro Val Gly Arg Pro Val Gln 
545                 550                 555                 560 


Glu Glu Thr Leu Ala His Arg Asp Ser Phe Ala Gly Thr Ala Pro Arg 
                565                 570                 575     


Phe Pro Asp Val Cys Ala Thr Gly Ala Gly Leu Gln Glu Gln Gly Ala 
            580                 585                 590         


Pro Arg Gln Lys Asp Gly Thr Ser Arg Pro Val Gln Glu Gln Gly Gly 
        595                 600                 605             


Ala Gln Thr Ser Leu His Thr Gln Gly Ser Gly Gln Cys Ala Glu 
    610                 615                 620             


