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<110>  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
       (INSERM)
 
<120>  ANTAGONISTS OF GRASP55 FOR USE AS A MEDICAMENT

<130>  BET 12P0084

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  451
<212>  PRT
<213>  Mus musculus

<400>  1

Met Gly Ser Ser Gln Ser Val Glu Ile Pro Gly Gly Gly Thr Glu Gly 
1               5                   10                  15      


Tyr His Val Leu Arg Val Gln Glu Asn Ser Pro Gly His Arg Ala Gly 
            20                  25                  30          


Leu Glu Pro Phe Phe Asp Phe Ile Val Ser Ile Asn Gly Ser Arg Leu 
        35                  40                  45              


Asn Lys Asp Asn Asp Thr Leu Lys Asp Leu Leu Lys Ala Asn Val Glu 
    50                  55                  60                  


Lys Pro Val Lys Met Leu Ile Tyr Ser Ser Lys Thr Leu Glu Leu Arg 
65                  70                  75                  80  


Glu Ala Ser Val Thr Pro Ser Asn Leu Trp Gly Gly Gln Gly Leu Leu 
                85                  90                  95      


Gly Val Ser Ile Arg Phe Cys Ser Phe Asp Gly Ala Asn Glu Asn Val 
            100                 105                 110         


Trp His Val Leu Glu Val Glu Ser Asn Ser Pro Ala Ala Leu Ala Gly 
        115                 120                 125             


Leu Arg Pro His Ser Asp Tyr Ile Ile Gly Ala Asp Thr Val Met Asn 
    130                 135                 140                 


Glu Ser Glu Asp Leu Phe Ser Leu Ile Glu Thr His Glu Ala Lys Pro 
145                 150                 155                 160 


Leu Lys Leu Tyr Val Tyr Asn Thr Asp Thr Asp Asn Cys Arg Glu Val 
                165                 170                 175     


Ile Ile Thr Pro Asn Ser Ala Trp Gly Gly Glu Gly Ser Leu Gly Cys 
            180                 185                 190         


Gly Ile Gly Tyr Gly Tyr Leu His Arg Ile Pro Thr Arg Pro Phe Glu 
        195                 200                 205             


Glu Gly Lys Lys Ile Ser Leu Pro Gly Gln Met Thr Gly Thr Pro Ile 
    210                 215                 220                 


Thr Pro Leu Lys Asp Gly Phe Thr Glu Val Gln Leu Ser Ser Val Ser 
225                 230                 235                 240 


Pro Pro Ser Leu Ser Pro Pro Gly Thr Thr Gly Val Glu Gln Ser Leu 
                245                 250                 255     


Ser Gly Leu Ser Ile Ser Ser Ala Pro Pro Ala Val Ser Asn Val Leu 
            260                 265                 270         


Ser Thr Gly Val Pro Thr Val Pro Leu Leu Pro Pro Gln Val Asn Gln 
        275                 280                 285             


Ser Leu Ala Ser Met Pro Pro Met Asn Pro Ala Thr Thr Leu Pro Ser 
    290                 295                 300                 


Leu Met Pro Leu Ser Ala Gly Leu Pro Ser Leu Pro Asn Leu Pro Ser 
305                 310                 315                 320 


Leu Ser Asn Phe Asn Leu Pro Ala Pro His Ile Met Pro Gly Val Gly 
                325                 330                 335     


Leu Pro Glu Leu Gly Ser Pro Gly Leu Pro Pro Leu Pro Ser Leu Pro 
            340                 345                 350         


Pro Arg Asn Leu Pro Gly Ile Ala Pro Leu Pro Met Leu Ser Asp Phe 
        355                 360                 365             


Leu Pro Ser Phe Pro Leu Val Pro Glu Gly Ser Ser Ala Ala Ser Ala 
    370                 375                 380                 


Gly Glu Pro Leu Ser Ser Leu Pro Ala Met Gly Pro Pro Ser Asp Pro 
385                 390                 395                 400 


Val Met Thr Thr Ala Lys Ala Asp Ala Ser Ser Leu Thr Val Asp Val 
                405                 410                 415     


Thr Ser Pro Ala Ser Lys Val Pro Thr Thr Val Glu Asp Arg Val Ser 
            420                 425                 430         


Asp Cys Thr Pro Ala Val Glu Lys Pro Val Ser Asp Ala Asp Ala Ser 
        435                 440                 445             


Glu Pro Ser 
    450     


<210>  2
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Ser Ser Gln Ser Val Glu Ile Pro Gly Gly Gly Thr Glu Gly 
1               5                   10                  15      


Tyr His Val Leu Arg Val Gln Glu Asn Ser Pro Gly His Arg Ala Gly 
            20                  25                  30          


Leu Glu Pro Phe Phe Asp Phe Ile Val Ser Ile Asn Gly Ser Arg Leu 
        35                  40                  45              


Asn Lys Asp Asn Asp Thr Leu Lys Asp Leu Leu Lys Ala Asn Val Glu 
    50                  55                  60                  


Lys Pro Val Lys Met Leu Ile Tyr Ser Ser Lys Thr Leu Glu Leu Arg 
65                  70                  75                  80  


Glu Thr Ser Val Thr Pro Ser Asn Leu Trp Gly Gly Gln Gly Leu Leu 
                85                  90                  95      


Gly Val Ser Ile Arg Phe Cys Ser Phe Asp Gly Ala Asn Glu Asn Val 
            100                 105                 110         


Trp His Val Leu Glu Val Glu Ser Asn Ser Pro Ala Ala Leu Ala Gly 
        115                 120                 125             


Leu Arg Pro His Ser Asp Tyr Ile Ile Gly Ala Asp Thr Val Met Asn 
    130                 135                 140                 


Glu Ser Glu Asp Leu Phe Ser Leu Ile Glu Thr His Glu Ala Lys Pro 
145                 150                 155                 160 


Leu Lys Leu Tyr Val Tyr Asn Thr Asp Thr Asp Asn Cys Arg Glu Val 
                165                 170                 175     


Ile Ile Thr Pro Asn Ser Ala Trp Gly Gly Glu Gly Ser Leu Gly Cys 
            180                 185                 190         


Gly Ile Gly Tyr Gly Tyr Leu His Arg Ile Pro Thr Arg Pro Phe Glu 
        195                 200                 205             


Glu Gly Lys Lys Ile Ser Leu Pro Gly Gln Met Ala Gly Thr Pro Ile 
    210                 215                 220                 


Thr Pro Leu Lys Asp Gly Phe Thr Glu Val Gln Leu Ser Ser Val Asn 
225                 230                 235                 240 


Pro Pro Ser Leu Ser Pro Pro Gly Thr Thr Gly Ile Glu Gln Ser Leu 
                245                 250                 255     


Thr Gly Leu Ser Ile Ser Ser Thr Pro Pro Ala Val Ser Ser Val Leu 
            260                 265                 270         


Ser Thr Gly Val Pro Thr Val Pro Leu Leu Pro Pro Gln Val Asn Gln 
        275                 280                 285             


Ser Leu Thr Ser Val Pro Pro Met Asn Pro Ala Thr Thr Leu Pro Gly 
    290                 295                 300                 


Leu Met Pro Leu Pro Ala Gly Leu Pro Asn Leu Pro Asn Leu Asn Leu 
305                 310                 315                 320 


Asn Leu Pro Ala Pro His Ile Met Pro Gly Val Gly Leu Pro Glu Leu 
                325                 330                 335     


Val Asn Pro Gly Leu Pro Pro Leu Pro Ser Met Pro Pro Arg Asn Leu 
            340                 345                 350         


Pro Gly Ile Ala Pro Leu Pro Leu Pro Ser Glu Phe Leu Pro Ser Phe 
        355                 360                 365             


Pro Leu Val Pro Glu Ser Ser Ser Ala Ala Ser Ser Gly Glu Leu Leu 
    370                 375                 380                 


Ser Ser Leu Pro Pro Thr Ser Asn Ala Pro Ser Asp Pro Ala Thr Thr 
385                 390                 395                 400 


Thr Ala Lys Ala Asp Ala Ala Ser Ser Leu Thr Val Asp Val Thr Pro 
                405                 410                 415     


Pro Thr Ala Lys Ala Pro Thr Thr Val Glu Asp Arg Val Gly Asp Ser 
            420                 425                 430         


Thr Pro Val Ser Glu Lys Pro Val Ser Ala Ala Val Asp Ala Asn Ala 
        435                 440                 445             


Ser Glu Ser Pro 
    450         


<210>  3
<211>  300
<212>  PRT
<213>  Mus musculus

<400>  3

Met Gly Thr Glu Gly Lys Ala Gly Arg Lys Leu Leu Phe Leu Phe Thr 
1               5                   10                  15      


Ser Met Ile Leu Gly Ser Leu Val Gln Gly Lys Gly Ser Val Tyr Thr 
            20                  25                  30          


Ala Gln Ser Asp Val Gln Val Pro Glu Asn Glu Ser Ile Lys Leu Thr 
        35                  40                  45              


Cys Thr Tyr Ser Gly Phe Ser Ser Pro Arg Val Glu Trp Lys Phe Val 
    50                  55                  60                  


Gln Gly Ser Thr Thr Ala Leu Val Cys Tyr Asn Ser Gln Ile Thr Ala 
65                  70                  75                  80  


Pro Tyr Ala Asp Arg Val Thr Phe Ser Ser Ser Gly Ile Thr Phe Ser 
                85                  90                  95      


Ser Val Thr Arg Lys Asp Asn Gly Glu Tyr Thr Cys Met Val Ser Glu 
            100                 105                 110         


Glu Gly Gly Gln Asn Tyr Gly Glu Val Ser Ile His Leu Thr Val Leu 
        115                 120                 125             


Val Pro Pro Ser Lys Pro Thr Ile Ser Val Pro Ser Ser Val Thr Ile 
    130                 135                 140                 


Gly Asn Arg Ala Val Leu Thr Cys Ser Glu His Asp Gly Ser Pro Pro 
145                 150                 155                 160 


Ser Glu Tyr Ser Trp Phe Lys Asp Gly Ile Ser Met Leu Thr Ala Asp 
                165                 170                 175     


Ala Lys Lys Thr Arg Ala Phe Met Asn Ser Ser Phe Thr Ile Asp Pro 
            180                 185                 190         


Lys Ser Gly Asp Leu Ile Phe Asp Pro Val Thr Ala Phe Asp Ser Gly 
        195                 200                 205             


Glu Tyr Tyr Cys Gln Ala Gln Asn Gly Tyr Gly Thr Ala Met Arg Ser 
    210                 215                 220                 


Glu Ala Ala His Met Asp Ala Val Glu Leu Asn Val Gly Gly Ile Val 
225                 230                 235                 240 


Ala Ala Val Leu Val Thr Leu Ile Leu Leu Gly Leu Leu Ile Phe Gly 
                245                 250                 255     


Val Trp Phe Ala Tyr Ser Arg Gly Tyr Phe Glu Thr Thr Lys Lys Gly 
            260                 265                 270         


Thr Ala Pro Gly Lys Lys Val Ile Tyr Ser Gln Pro Ser Thr Arg Ser 
        275                 280                 285             


Glu Gly Glu Phe Lys Gln Thr Ser Ser Phe Leu Val 
    290                 295                 300 


<210>  4
<211>  298
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Arg Ser Pro Gln Gly Leu Leu Met Leu Leu Leu Leu His Tyr 
1               5                   10                  15      


Leu Ile Val Ala Leu Asp Tyr His Lys Ala Asn Gly Phe Ser Ala Ser 
            20                  25                  30          


Lys Asp His Arg Gln Glu Val Thr Val Ile Glu Phe Gln Glu Ala Ile 
        35                  40                  45              


Leu Ala Cys Lys Thr Pro Lys Lys Thr Thr Ser Ser Arg Leu Glu Trp 
    50                  55                  60                  


Lys Lys Val Gly Gln Gly Val Ser Leu Val Tyr Tyr Gln Gln Ala Leu 
65                  70                  75                  80  


Gln Gly Asp Phe Lys Asp Arg Ala Glu Met Ile Asp Phe Asn Ile Arg 
                85                  90                  95      


Ile Lys Asn Val Thr Arg Ser Asp Ala Gly Glu Tyr Arg Cys Glu Val 
            100                 105                 110         


Ser Ala Pro Thr Glu Gln Gly Gln Asn Leu Gln Glu Asp Lys Val Met 
        115                 120                 125             


Leu Glu Val Leu Val Ala Pro Ala Val Pro Ala Cys Glu Val Pro Thr 
    130                 135                 140                 


Ser Val Met Thr Gly Ser Val Val Glu Leu Arg Cys Gln Asp Lys Glu 
145                 150                 155                 160 


Gly Asn Pro Ala Pro Glu Tyr Ile Trp Phe Lys Asp Gly Thr Ser Leu 
                165                 170                 175     


Leu Gly Asn Pro Lys Gly Gly Thr His Asn Asn Ser Ser Tyr Thr Met 
            180                 185                 190         


Asn Thr Lys Ser Gly Ile Leu Gln Phe Asn Met Ile Ser Lys Met Asp 
        195                 200                 205             


Ser Gly Glu Tyr Tyr Cys Glu Ala Arg Asn Ser Val Gly His Arg Arg 
    210                 215                 220                 


Cys Pro Gly Lys Arg Met Gln Val Asp Val Leu Asn Ile Ser Gly Ile 
225                 230                 235                 240 


Ile Ala Thr Val Val Val Val Ala Phe Val Ile Ser Val Cys Gly Leu 
                245                 250                 255     


Gly Thr Cys Tyr Ala Gln Arg Lys Gly Tyr Phe Ser Lys Glu Thr Ser 
            260                 265                 270         


Phe Gln Lys Gly Ser Pro Ala Ser Lys Val Thr Thr Met Ser Glu Asn 
        275                 280                 285             


Asp Phe Lys His Thr Lys Ser Phe Ile Ile 
    290                 295             


<210>  5
<211>  310
<212>  PRT
<213>  Mus musculus

<400>  5

Met Ala Leu Ser Arg Arg Leu Arg Leu Arg Leu Tyr Ala Arg Leu Pro 
1               5                   10                  15      


Asp Phe Phe Leu Leu Leu Leu Phe Arg Gly Cys Met Ile Glu Ala Val 
            20                  25                  30          


Asn Leu Lys Ser Ser Asn Arg Asn Pro Val Val His Glu Phe Glu Ser 
        35                  40                  45              


Val Glu Leu Ser Cys Ile Ile Thr Asp Ser Gln Thr Ser Asp Pro Arg 
    50                  55                  60                  


Ile Glu Trp Lys Lys Ile Gln Asp Gly Gln Thr Thr Tyr Val Tyr Phe 
65                  70                  75                  80  


Asp Asn Lys Ile Gln Gly Asp Leu Ala Gly Arg Thr Asp Val Phe Gly 
                85                  90                  95      


Lys Thr Ser Leu Arg Ile Trp Asn Val Thr Arg Ser Asp Ser Ala Ile 
            100                 105                 110         


Tyr Arg Cys Glu Val Val Ala Leu Asn Asp Arg Lys Glu Val Asp Glu 
        115                 120                 125             


Ile Thr Ile Glu Leu Ile Val Gln Val Lys Pro Val Thr Pro Val Cys 
    130                 135                 140                 


Arg Ile Pro Ala Ala Val Pro Val Gly Lys Thr Ala Thr Leu Gln Cys 
145                 150                 155                 160 


Gln Glu Ser Glu Gly Tyr Pro Arg Pro His Tyr Ser Trp Tyr Arg Asn 
                165                 170                 175     


Asp Val Pro Leu Pro Thr Asp Ser Arg Ala Asn Pro Arg Phe Gln Asn 
            180                 185                 190         


Ser Ser Phe His Val Asn Ser Glu Thr Gly Thr Leu Val Phe Asn Ala 
        195                 200                 205             


Val His Lys Asp Asp Ser Gly Gln Tyr Tyr Cys Ile Ala Ser Asn Asp 
    210                 215                 220                 


Ala Gly Ala Ala Arg Cys Glu Gly Gln Asp Met Glu Val Tyr Asp Leu 
225                 230                 235                 240 


Asn Ile Ala Gly Ile Ile Gly Gly Val Leu Val Val Leu Ile Val Leu 
                245                 250                 255     


Ala Val Ile Thr Met Gly Ile Cys Cys Ala Tyr Arg Arg Gly Cys Phe 
            260                 265                 270         


Ile Ser Ser Lys Gln Asp Gly Glu Ser Tyr Lys Ser Pro Gly Lys His 
        275                 280                 285             


Asp Gly Val Asn Tyr Ile Arg Thr Ser Glu Glu Gly Asp Phe Arg His 
    290                 295                 300                 


Lys Ser Ser Phe Val Ile 
305                 310 


<210>  6
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA

<400>  6
cgucaugaau gagucugaat t                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA

<400>  7
aagugaucau cacaccaaat t                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA

<400>  8
cgguucaaga uuaaauaaat t                                                 21


<210>  9
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA

<400>  9
gcaucucuau uacgguuua                                                    19


<210>  10
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA

<400>  10
uguagcuacu uaacgguau                                                    19


<210>  11
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  11
cggttcaaga ttaaataaat t                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  shRNA (sense strand)

<400>  12
cgguucaaga uuaaauaaat t                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  shRNA (antisense strand)

<400>  13
aatttattta atcttgaacc g                                                 21


<210>  14
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  14
tgtgaggtcg ttgctctaaa tga                                               23


<210>  15
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  15
cactggcttc acttgcacaa tt                                                22


<210>  16
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  16
tcggtttgcc agagctcg                                                     18


<210>  17
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  17
gggaatgacg ggaggaagtc                                                   20


<210>  18
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  18
ggccctctgt gtgctcaag                                                    19


<210>  19
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  19
ctgataaaat ctacagtcat aggaatgga                                         29


<210>  20
<211>  68
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  20
gatcccccgg ttcaagatta aataaatttt caagagaaat ttatttaatc ttgaaccgtt       60

tttggaaa                                                                68


<210>  21
<211>  68
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  21
agcttttcca aaaacggttc aagattaaat aaatttctct tgaaaattta tttaatcttg       60

aaccgggg                                                                68


<210>  22
<211>  218
<212>  PRT
<213>  Schistosoma japonicum

<400>  22

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys 
    210                 215             


<210>  23
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Gly Thr Lys Ala Gln Val Glu Arg Lys Leu Leu Cys Leu Phe Ile 
1               5                   10                  15      


Leu Ala Ile Leu Leu Cys Ser Leu Ala Leu Gly Ser Val Thr Val His 
            20                  25                  30          


Ser Ser Glu Pro Glu Val Arg Ile Pro Glu Asn Asn Pro Val Lys Leu 
        35                  40                  45              


Ser Cys Ala Tyr Ser Gly Phe Ser Ser Pro Arg Val Glu Trp Lys Phe 
    50                  55                  60                  


Asp Gln Gly Asp Thr Thr Arg Leu Val Cys Tyr Asn Asn Lys Ile Thr 
65                  70                  75                  80  


Ala Ser Tyr Glu Asp Arg Val Thr Phe Leu Pro Thr Gly Ile Thr Phe 
                85                  90                  95      


Lys Ser Val Thr Arg Glu Asp Thr Gly Thr Tyr Thr Cys Met Val Ser 
            100                 105                 110         


Glu Glu Gly Gly Asn Ser Tyr Gly Glu Val Lys Val Lys Leu Ile Val 
        115                 120                 125             


Leu Val Pro Pro Ser Lys Pro Thr Val Asn Ile Pro Ser Ser Ala Thr 
    130                 135                 140                 


Ile Gly Asn Arg Ala Val Leu Thr Cys Ser Glu Gln Asp Gly Ser Pro 
145                 150                 155                 160 


Pro Ser Glu Tyr Thr Trp Phe Lys Asp Gly Ile Val Met Pro Thr Asn 
                165                 170                 175     


Pro Lys Ser Thr Arg Ala Phe Ser Asn Ser Ser Tyr Val Leu Asn Pro 
            180                 185                 190         


Thr Thr Gly Glu Leu Val Phe Asp Pro Leu Ser Ala Ser Asp Thr Gly 
        195                 200                 205             


Glu Tyr Ser Cys Glu Ala Arg Asn Gly Tyr Gly Thr Pro Met Thr Ser 
    210                 215                 220                 


Asn Ala Val Arg Met Glu Ala Val Glu Arg Asn Val Gly Val Ile Val 
225                 230                 235                 240 


Ala Ala Val Leu Val Thr Leu Ile Leu Leu Gly Ile Leu Val Phe Gly 
                245                 250                 255     


Ile Trp Phe Ala Tyr Ser Arg Gly His Phe Asp Arg Thr Lys Lys Gly 
            260                 265                 270         


Thr Ser Ser Lys Lys Val Ile Tyr Ser Gln Pro Ser Ala Arg Ser Glu 
        275                 280                 285             


Gly Glu Phe Lys Gln Thr Ser Ser Phe Leu Val 
    290                 295                 


<210>  24
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Arg Arg Ser Arg His Arg Leu Leu Leu Leu Leu Leu Arg Tyr 
1               5                   10                  15      


Leu Val Val Ala Leu Gly Tyr His Lys Ala Tyr Gly Phe Ser Ala Pro 
            20                  25                  30          


Lys Asp Gln Gln Val Val Thr Ala Val Glu Tyr Gln Glu Ala Ile Leu 
        35                  40                  45              


Ala Cys Lys Thr Pro Lys Lys Thr Val Ser Ser Arg Leu Glu Trp Lys 
    50                  55                  60                  


Lys Leu Gly Arg Ser Val Ser Phe Val Tyr Tyr Gln Gln Thr Leu Gln 
65                  70                  75                  80  


Gly Asp Phe Lys Asn Arg Ala Glu Met Ile Asp Phe Asn Ile Arg Ile 
                85                  90                  95      


Lys Asn Val Thr Arg Ser Asp Ala Gly Lys Tyr Arg Cys Glu Val Ser 
            100                 105                 110         


Ala Pro Ser Glu Gln Gly Gln Asn Leu Glu Glu Asp Thr Val Thr Leu 
        115                 120                 125             


Glu Val Leu Val Ala Pro Ala Val Pro Ser Cys Glu Val Pro Ser Ser 
    130                 135                 140                 


Ala Leu Ser Gly Thr Val Val Glu Leu Arg Cys Gln Asp Lys Glu Gly 
145                 150                 155                 160 


Asn Pro Ala Pro Glu Tyr Thr Trp Phe Lys Asp Gly Ile Arg Leu Leu 
                165                 170                 175     


Glu Asn Pro Arg Leu Gly Ser Gln Ser Thr Asn Ser Ser Tyr Thr Met 
            180                 185                 190         


Asn Thr Lys Thr Gly Thr Leu Gln Phe Asn Thr Val Ser Lys Leu Asp 
        195                 200                 205             


Thr Gly Glu Tyr Ser Cys Glu Ala Arg Asn Ser Val Gly Tyr Arg Arg 
    210                 215                 220                 


Cys Pro Gly Lys Arg Met Gln Val Asp Asp Leu Asn Ile Ser Gly Ile 
225                 230                 235                 240 


Ile Ala Ala Val Val Val Val Ala Leu Val Ile Ser Val Cys Gly Leu 
                245                 250                 255     


Gly Val Cys Tyr Ala Gln Arg Lys Gly Tyr Phe Ser Lys Glu Thr Ser 
            260                 265                 270         


Phe Gln Lys Ser Asn Ser Ser Ser Lys Ala Thr Thr Met Ser Glu Asn 
        275                 280                 285             


Asp Phe Lys His Thr Lys Ser Phe Ile Ile 
    290                 295             


<210>  25
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Leu Arg Arg Pro Pro Arg Leu Arg Leu Cys Ala Arg Leu Pro 
1               5                   10                  15      


Asp Phe Phe Leu Leu Leu Leu Phe Arg Gly Cys Leu Ile Gly Ala Val 
            20                  25                  30          


Asn Leu Lys Ser Ser Asn Arg Thr Pro Val Val Gln Glu Phe Glu Ser 
        35                  40                  45              


Val Glu Leu Ser Cys Ile Ile Thr Asp Ser Gln Thr Ser Asp Pro Arg 
    50                  55                  60                  


Ile Glu Trp Lys Lys Ile Gln Asp Glu Gln Thr Thr Tyr Val Phe Phe 
65                  70                  75                  80  


Asp Asn Lys Ile Gln Gly Asp Leu Ala Gly Arg Ala Glu Ile Leu Gly 
                85                  90                  95      


Lys Thr Ser Leu Lys Ile Trp Asn Val Thr Arg Arg Asp Ser Ala Leu 
            100                 105                 110         


Tyr Arg Cys Glu Val Val Ala Arg Asn Asp Arg Lys Glu Ile Asp Glu 
        115                 120                 125             


Ile Val Ile Glu Leu Thr Val Gln Val Lys Pro Val Thr Pro Val Cys 
    130                 135                 140                 


Arg Val Pro Lys Ala Val Pro Val Gly Lys Met Ala Thr Leu His Cys 
145                 150                 155                 160 


Gln Glu Ser Glu Gly His Pro Arg Pro His Tyr Ser Trp Tyr Arg Asn 
                165                 170                 175     


Asp Val Pro Leu Pro Thr Asp Ser Arg Ala Asn Pro Arg Phe Arg Asn 
            180                 185                 190         


Ser Ser Phe His Leu Asn Ser Glu Thr Gly Thr Leu Val Phe Thr Ala 
        195                 200                 205             


Val His Lys Asp Asp Ser Gly Gln Tyr Tyr Cys Ile Ala Ser Asn Asp 
    210                 215                 220                 


Ala Gly Ser Ala Arg Cys Glu Glu Gln Glu Met Glu Val Tyr Asp Leu 
225                 230                 235                 240 


Asn Ile Gly Gly Ile Ile Gly Gly Val Leu Val Val Leu Ala Val Leu 
                245                 250                 255     


Ala Leu Ile Thr Leu Gly Ile Cys Cys Ala Tyr Arg Arg Gly Tyr Phe 
            260                 265                 270         


Ile Asn Asn Lys Gln Asp Gly Glu Ser Tyr Lys Asn Pro Gly Lys Pro 
        275                 280                 285             


Asp Gly Val Asn Tyr Ile Arg Thr Asp Glu Glu Gly Asp Phe Arg His 
    290                 295                 300                 


Lys Ser Ser Phe Val Ile 
305                 310 


<210>  26
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  26

Ser Gln Pro Ser Thr Arg Ser Glu Gly Glu Phe Lys Gln Thr Ser Ser 
1               5                   10                  15      


Phe Leu Val 
            


<210>  27
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  27

Ser Gln Pro Ser Thr Arg Ser Glu Gly Glu Phe Lys Gln Thr Ser Ser 
1               5                   10                  15      


<210>  28
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  28

Ser Lys Val Thr Thr Met Ser Glu Asn Asp Phe Lys His Thr Lys Ser 
1               5                   10                  15      


Phe Ile Ile 
            


<210>  29
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  29

Ser Lys Val Thr Thr Met Ser Glu Asn Asp Phe Lys His Thr Lys Ser 
1               5                   10                  15      


<210>  30
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  30

Asn Tyr Ile Arg Thr Ser Glu Glu Gly Asp Phe Arg His Lys Ser Ser 
1               5                   10                  15      


Phe Val Ile 
            


<210>  31
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  31

Asn Tyr Ile Arg Thr Ser Glu Glu Gly Asp Phe Arg His Lys Ser Ser 
1               5                   10                  15      


<210>  32
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  consensus

<400>  32

Asn Gln Pro Ser Thr Met Ser Glu Asn Asp Phe Lys Gln Thr Lys Ser 
1               5                   10                  15      


Phe Ile Ile 
            


<210>  33
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  consensus


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  33

Ser Lys Val Thr Xaa Arg Glu Xaa Gly Glu Xaa Arg His Lys Ser Xaa 
1               5                   10                  15      


Xaa Leu Val 
            


<210>  34
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  consensus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be any naturally occurring amino acid

<400>  34

Xaa Tyr Ile Arg Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Val Xaa 
            


<210>  35
<211>  42
<212>  PRT
<213>  Artificial

<220>
<223>  Fragment of human JAM-A

<400>  35

Trp Phe Ala Tyr Ser Arg Gly His Phe Asp Arg Thr Lys Lys Gly Thr 
1               5                   10                  15      


Ser Ser Lys Lys Val Ile Tyr Ser Gln Pro Ser Ala Arg Ser Glu Gly 
            20                  25                  30          


Glu Phe Lys Gln Thr Ser Ser Phe Leu Val 
        35                  40          


<210>  36
<211>  43
<212>  PRT
<213>  Artificial

<220>
<223>  Fragment of murine JAM-A

<400>  36

Trp Phe Ala Tyr Ser Arg Gly Tyr Phe Glu Thr Thr Lys Lys Gly Thr 
1               5                   10                  15      


Ala Pro Gly Lys Lys Val Ile Tyr Ser Gln Pro Ser Thr Arg Ser Glu 
            20                  25                  30          


Gly Glu Phe Lys Gln Thr Ser Ser Phe Leu Val 
        35                  40              


<210>  37
<211>  40
<212>  PRT
<213>  Artificial

<220>
<223>  Fragment of human JAM-B

<400>  37

Cys Tyr Ala Gln Arg Lys Gly Tyr Phe Ser Lys Glu Thr Ser Phe Gln 
1               5                   10                  15      


Lys Ser Asn Ser Ser Ser Lys Ala Thr Thr Met Ser Glu Asn Asp Phe 
            20                  25                  30          


Lys His Thr Lys Ser Phe Ile Ile 
        35                  40  


<210>  38
<211>  40
<212>  PRT
<213>  Artificial

<220>
<223>  Fragment of murine JAM-B

<400>  38

Cys Tyr Ala Gln Arg Lys Gly Tyr Phe Ser Lys Glu Thr Ser Phe Gln 
1               5                   10                  15      


Lys Gly Ser Pro Ala Ser Lys Val Thr Thr Met Ser Glu Asn Asp Phe 
            20                  25                  30          


Lys His Thr Lys Ser Phe Ile Ile 
        35                  40  


<210>  39
<211>  47
<212>  PRT
<213>  Artificial

<220>
<223>  Fragment of human JAM-C

<400>  39

Cys Cys Ala Tyr Arg Arg Gly Tyr Phe Ile Asn Asn Lys Gln Asp Gly 
1               5                   10                  15      


Glu Ser Tyr Lys Asn Pro Gly Lys Pro Asp Gly Val Asn Tyr Ile Arg 
            20                  25                  30          


Thr Asp Glu Glu Gly Asp Phe Arg His Lys Ser Ser Phe Val Ile 
        35                  40                  45          


<210>  40
<211>  47
<212>  PRT
<213>  Artificial

<220>
<223>  fragment of murine JAM-C

<400>  40

Cys Cys Ala Tyr Arg Arg Gly Cys Phe Ile Ser Ser Lys Gln Asp Gly 
1               5                   10                  15      


Glu Ser Tyr Lys Ser Pro Gly Lys His Asp Gly Val Asn Tyr Ile Arg 
            20                  25                  30          


Thr Ser Glu Glu Gly Asp Phe Arg His Lys Ser Ser Phe Val Ile 
        35                  40                  45          


<210>  41
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  41

Gly Phe Ile Lys Ile Cys Ser Val His Thr Pro Ser Ser Asn Pro Lys 
1               5                   10                  15      


Leu Pro Pro Pro Lys Pro Leu Pro Gly Thr Leu Lys Arg Arg Arg Pro 
            20                  25                  30          


Pro Gln Pro Ile Gln Gln Pro Pro Arg Gln Arg Pro Arg Glu Tyr Gln 
        35                  40                  45              


Met Gly His Met Arg Arg 
    50                  


<210>  42
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  42

Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser Leu Ser Leu Phe 
1               5                   10                  15      


His His Ser Asn Ile Glu Met Leu Ser Ser Met Asp Ser Ala Ser Val 
            20                  25                  30          


Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro Gly Arg Leu Gln 
        35                  40                  45              


Ala Leu Gln Pro Ala Ala Met Met Pro Pro Val Ser Ala Ala Pro Lys 
    50                  55                  60                  


Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr Asp 
65                  70                  75                  80  


Ser His Val Asp Asp Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn Ser 
                85                  90                  95      


Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val Thr 
            100                 105                 110         


Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Ser Arg Val 
        115                 120                 125             


Asp Ser Lys Glu Thr Glu Cys 
    130                 135 


