                         SEQUENCE LISTING

<110>  Cytavis Biopharma GmbH
 
<120>  Antivirales Mittel enthaltend rekombinante Mistellektine

<130>  CYT24WO

<160>  12    

<170>  PatentIn version 3.3

<210>  1
<211>  253
<212>  PRT
<213>  Artificial

<220>
<223>  EP0751221 recombinant Protein


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be Met or can be deleted

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be Ile or Leu

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be Glu or Asp 

<400>  1

Xaa Tyr Glu Arg Xaa Arg Leu Arg Val Thr His Gln Thr Thr Gly Xaa 
1               5                   10                  15      


Glu Tyr Phe Arg Phe Ile Thr Leu Leu Arg Asp Tyr Val Ser Ser Gly 
            20                  25                  30          


Ser Phe Ser Asn Glu Ile Pro Leu Leu Arg Gln Ser Thr Ile Pro Val 
        35                  40                  45              


Ser Asp Ala Gln Arg Phe Val Leu Val Glu Leu Thr Asn Gln Gly Gly 
    50                  55                  60                  


Asp Ser Ile Thr Ala Ala Ile Asp Val Thr Asn Leu Tyr Val Val Ala 
65                  70                  75                  80  


Tyr Gln Ala Gly Asp Gln Ser Tyr Phe Leu Arg Asp Ala Pro Arg Gly 
                85                  90                  95      


Ala Glu Thr His Leu Phe Thr Gly Thr Thr Arg Ser Ser Leu Pro Phe 
            100                 105                 110         


Asn Gly Ser Tyr Pro Asp Leu Glu Arg Tyr Ala Gly His Arg Asp Gln 
        115                 120                 125             


Ile Pro Leu Gly Ile Asp Gln Leu Ile Gln Ser Val Thr Ala Leu Arg 
    130                 135                 140                 


Phe Pro Gly Gly Ser Thr Arg Thr Gln Ala Arg Ser Ile Leu Ile Leu 
145                 150                 155                 160 


Ile Gln Met Ile Ser Glu Ala Ala Arg Phe Asn Pro Ile Leu Trp Arg 
                165                 170                 175     


Ala Arg Gln Tyr Ile Asn Ser Gly Ala Ser Phe Leu Pro Asp Val Tyr 
            180                 185                 190         


Met Leu Glu Leu Glu Thr Ser Trp Gly Gln Gln Ser Thr Gln Val Gln 
        195                 200                 205             


His Ser Thr Asp Gly Val Phe Asn Asn Pro Ile Arg Leu Ala Ile Pro 
    210                 215                 220                 


Pro Gly Asn Phe Val Thr Leu Thr Asn Val Arg Asp Val Ile Ala Ser 
225                 230                 235                 240 


Leu Ala Ile Met Leu Phe Val Cys Gly Glu Arg Pro Ser 
                245                 250             


<210>  2
<211>  256
<212>  PRT
<213>  Artificial

<220>
<223>  EP1051495 recombinant Protein


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be Met or can be deleted

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be Asp or Glu
<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa can be Gly or Gln
<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa can be Ile or Val

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa can be Leu or Ala
<220>
<221>  misc_feature
<222>  (108)..(108)
<223>  Xaa can be Asp-Arg or can be deleted

<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  Xaa can be Asn or Thr

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  Xaa can be Pro or Thr

<220>
<221>  misc_feature
<222>  (135)..(135)
<223>  Xaa can be Asp or Glu

<220>
<221>  misc_feature
<222>  (142)..(142)
<223>  Xaa can be Ser or Thr

<220>
<221>  misc_feature
<222>  (146)..(146)
<223>  Xaa can be Phe or Tyr

<220>
<221>  misc_feature
<222>  (153)..(153)
<223>  Xaa can be Ala or Thr

<220>
<221>  misc_feature
<222>  (178)..(178)
<223>  Xaa can be Ala or Tyr
<220>
<221>  misc_feature
<222>  (181)..(181)
<223>  Xaa can be Tyr or Asp

<220>
<221>  misc_feature
<222>  (186)..(186)
<223>  Xaa can be Ala or Glu

<220>
<221>  misc_feature
<222>  (192)..(192)
<223>  Xaa can be Val or Met
<220>
<221>  misc_feature
<222>  (220)..(220)
<223>  Xaa can be Ile or Phe

<220>
<221>  misc_feature
<222>  (225)..(226)
<223>  Xaa can be Pro-Ser or Pro-Thr

<220>
<221>  misc_feature
<222>  (233)..(233)
<223>  Xaa can be Thr or Ser

<220>
<221>  misc_feature
<222>  (237)..(237)
<223>  Xaa can be Asp or Ser

<220>
<221>  misc_feature
<222>  (255)..(256)
<223>  Xaa can be Ser-Ser or can be deleted

<400>  2

Xaa Tyr Glu Arg Leu Arg Leu Arg Val Thr His Gln Thr Thr Gly Xaa 
1               5                   10                  15      


Glu Tyr Phe Arg Phe Ile Thr Leu Leu Arg Asp Tyr Val Ser Ser Gly 
            20                  25                  30          


Ser Phe Ser Asn Glu Ile Pro Leu Leu Arg Gln Ser Thr Ile Pro Val 
        35                  40                  45              


Ser Asp Ala Gln Arg Phe Val Leu Val Glu Leu Thr Asn Gln Gly Xaa 
    50                  55                  60                  


Asp Ser Xaa Thr Ala Ala Ile Asp Val Thr Asn Xaa Tyr Val Val Ala 
65                  70                  75                  80  


Tyr Gln Ala Gly Asp Gln Ser Tyr Phe Leu Arg Asp Ala Pro Arg Gly 
                85                  90                  95      


Ala Glu Thr His Leu Phe Thr Gly Thr Thr Arg Xaa Ser Ser Leu Pro 
            100                 105                 110         


Phe Xaa Gly Ser Tyr Xaa Asp Leu Glu Arg Tyr Ala Gly His Arg Asp 
        115                 120                 125             


Gln Ile Pro Leu Gly Ile Xaa Gln Leu Ile Gln Ser Val Xaa Ala Leu 
    130                 135                 140                 


Arg Xaa Pro Gly Gly Ser Thr Arg Xaa Gln Ala Arg Ser Ile Leu Ile 
145                 150                 155                 160 


Leu Ile Gln Met Ile Ser Glu Ala Ala Arg Phe Asn Pro Ile Leu Trp 
                165                 170                 175     


Arg Xaa Arg Gln Xaa Ile Asn Ser Gly Xaa Ser Phe Leu Pro Asp Xaa 
            180                 185                 190         


Tyr Met Leu Glu Leu Glu Thr Ser Trp Gly Gln Gln Ser Thr Gln Val 
        195                 200                 205             


Gln His Ser Thr Asp Gly Val Phe Asn Asn Pro Xaa Arg Leu Ala Ile 
    210                 215                 220                 


Xaa Xaa Gly Asn Phe Val Thr Leu Xaa Asn Val Arg Xaa Val Ile Ala 
225                 230                 235                 240 


Ser Leu Ala Ile Met Leu Phe Val Cys Gly Glu Arg Pro Ser Xaa Xaa 
                245                 250                 255     


<210>  3
<211>  257
<212>  PRT
<213>  Artificial

<220>
<223>  EP1051495 recombinant Protein


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be Met or can be deleted

<400>  3

Xaa Tyr Glu Arg Leu Arg Leu Arg Val Thr His Gln Thr Thr Gly Asp 
1               5                   10                  15      


Glu Tyr Phe Arg Phe Ile Thr Leu Leu Arg Asp Tyr Val Ser Ser Gly 
            20                  25                  30          


Ser Phe Ser Asn Glu Ile Pro Leu Leu Arg Gln Ser Thr Ile Pro Val 
        35                  40                  45              


Ser Asp Ala Gln Arg Phe Val Leu Val Glu Leu Thr Asn Gln Gly Gln 
    50                  55                  60                  


Asp Ser Ile Thr Ala Ala Ile Asp Val Thr Asn Ala Tyr Val Val Ala 
65                  70                  75                  80  


Tyr Gln Ala Gly Asp Gln Ser Tyr Phe Leu Arg Asp Ala Pro Arg Gly 
                85                  90                  95      


Ala Glu Thr His Leu Phe Thr Gly Thr Thr Arg Asp Arg Ser Ser Leu 
            100                 105                 110         


Pro Phe Thr Gly Ser Tyr Thr Asp Leu Glu Arg Tyr Ala Gly His Arg 
        115                 120                 125             


Asp Gln Ile Pro Leu Gly Ile Glu Gln Leu Ile Gln Ser Val Ser Ala 
    130                 135                 140                 


Leu Arg Tyr Pro Gly Gly Ser Thr Arg Ala Gln Ala Arg Ser Ile Leu 
145                 150                 155                 160 


Ile Leu Ile Gln Met Ile Ser Glu Ala Ala Arg Phe Asn Pro Ile Leu 
                165                 170                 175     


Trp Arg Tyr Arg Gln Asp Ile Asn Ser Gly Glu Ser Phe Leu Pro Asp 
            180                 185                 190         


Met Tyr Met Leu Glu Leu Glu Thr Ser Trp Gly Gln Gln Ser Thr Gln 
        195                 200                 205             


Val Gln His Ser Thr Asp Gly Val Phe Asn Asn Pro Phe Arg Leu Ala 
    210                 215                 220                 


Ile Ser Thr Gly Asn Phe Val Thr Leu Ser Asn Val Arg Ser Val Ile 
225                 230                 235                 240 


Ala Ser Leu Ala Ile Met Leu Phe Val Cys Gly Glu Arg Pro Ser Ser 
                245                 250                 255     


Ser 
    


<210>  4
<211>  264
<212>  PRT
<213>  Artificial

<220>
<223>  EP0751221 recombinant Protein


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be Met or can be deleted

<400>  4

Xaa Asp Asp Val Thr Cys Ser Ala Ser Glu Pro Thr Val Arg Ile Val 
1               5                   10                  15      


Gly Arg Asn Gly Met Cys Val Asp Val Arg Asp Asp Asp Phe Arg Asp 
            20                  25                  30          


Gly Asn Gln Ile Gln Leu Trp Pro Ser Lys Ser Asn Asn Asp Pro Asn 
        35                  40                  45              


Gln Leu Trp Thr Ile Lys Arg Asp Gly Thr Ile Arg Ser Asn Gly Ser 
    50                  55                  60                  


Cys Leu Thr Thr Tyr Gly Tyr Thr Ala Gly Val Tyr Val Met Ile Phe 
65                  70                  75                  80  


Asp Cys Asn Thr Ala Val Arg Glu Ala Thr Leu Trp Gln Ile Trp Gly 
                85                  90                  95      


Asn Gly Thr Ile Ile Asn Pro Arg Ser Asn Leu Val Leu Ala Ala Ser 
            100                 105                 110         


Ser Gly Ile Lys Gly Thr Thr Leu Thr Val Gln Thr Leu Asp Tyr Thr 
        115                 120                 125             


Leu Gly Gln Gly Trp Leu Ala Gly Asn Asp Thr Ala Pro Arg Glu Val 
    130                 135                 140                 


Thr Ile Tyr Gly Phe Arg Asp Leu Cys Met Glu Ser Asn Gly Gly Ser 
145                 150                 155                 160 


Val Trp Val Glu Thr Cys Val Ser Ser Gln Lys Asn Gln Arg Trp Ala 
                165                 170                 175     


Leu Tyr Gly Asp Gly Ser Ile Arg Pro Lys Gln Asn Gln Asp Gln Cys 
            180                 185                 190         


Leu Thr Cys Gly Arg Asp Ser Val Ser Thr Val Ile Asn Ile Val Ser 
        195                 200                 205             


Cys Ser Ala Gly Ser Ser Gly Gln Arg Trp Val Phe Thr Asn Glu Gly 
    210                 215                 220                 


Ala Ile Leu Asn Leu Lys Asn Gly Leu Ala Met Asp Val Ala Gln Ala 
225                 230                 235                 240 


Asn Pro Lys Leu Arg Arg Ile Ile Ile Tyr Pro Ala Thr Gly Lys Pro 
                245                 250                 255     


Asn Gln Met Trp Leu Pro Val Pro 
            260                 


<210>  5
<211>  268
<212>  PRT
<213>  Artificial

<220>
<223>  EP0751221 recombinant Protein


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be Met or can be deleted

<400>  5

Xaa Asp Asp Val Thr Cys Ser Ala Ser Glu Pro Thr Val Arg Ile Val 
1               5                   10                  15      


Gly Arg Asn Gly Met Cys Val Asp Val Arg Asp Asp Asp Phe Arg Asp 
            20                  25                  30          


Gly Asn Gln Ile Gln Leu Trp Pro Ser Lys Ser Asn Asn Asp Pro Asn 
        35                  40                  45              


Gln Leu Trp Thr Ile Lys Arg Asp Gly Thr Ile Arg Ser Asn Gly Ser 
    50                  55                  60                  


Cys Leu Thr Thr Tyr Gly Tyr Thr Ala Gly Val Tyr Val Met Ile Phe 
65                  70                  75                  80  


Asp Cys Asn Thr Ala Val Arg Glu Ala Thr Leu Trp Gln Ile Trp Gly 
                85                  90                  95      


Asn Gly Thr Ile Ile Asn Pro Arg Ser Asn Leu Val Leu Ala Ala Ser 
            100                 105                 110         


Ser Gly Ile Lys Gly Thr Thr Leu Thr Val Gln Thr Leu Asp Tyr Thr 
        115                 120                 125             


Leu Gly Gln Gly Trp Leu Ala Gly Asn Asp Thr Ala Pro Arg Glu Val 
    130                 135                 140                 


Thr Ile Tyr Gly Phe Arg Asp Leu Cys Met Glu Ser Asn Gly Gly Ser 
145                 150                 155                 160 


Val Trp Val Glu Thr Cys Val Ser Ser Gln Lys Asn Gln Arg Trp Ala 
                165                 170                 175     


Leu Tyr Gly Asp Gly Ser Ile Arg Pro Lys Gln Asn Gln Asp Gln Cys 
            180                 185                 190         


Leu Thr Cys Gly Arg Asp Ser Val Ser Thr Val Ile Asn Ile Val Ser 
        195                 200                 205             


Cys Ser Ala Gly Ser Ser Gly Gln Arg Trp Val Phe Thr Asn Glu Gly 
    210                 215                 220                 


Ala Ile Leu Asn Leu Lys Asn Gly Leu Ala Met Asp Val Ala Gln Ala 
225                 230                 235                 240 


Asn Pro Lys Leu Arg Arg Ile Ile Ile Tyr Pro Ala Thr Gly Lys Pro 
                245                 250                 255     


Asn Gln Met Trp Leu Pro Val Pro Gly Gly Tyr His 
            260                 265             


<210>  6
<211>  265
<212>  PRT
<213>  Artificial

<220>
<223>  EP1051495 recombinant Protein


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be Met or can be deleted

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be Asn or Ser

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be Cys or Arg

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa can be Gly or Asn 

<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  Xaa can be Gly or Asn

<220>
<221>  misc_feature
<222>  (158)..(158)
<223>  Xaa can be Gly or Gln
<220>
<221>  misc_feature
<222>  (167)..(167)
<223>  Xaa can be Val or Asp

<220>
<221>  misc_feature
<222>  (171)..(171)
<223>  Xaa can be Gln or Lys

<220>
<221>  misc_feature
<222>  (174)..(175)
<223>  Xaa can be Gly or can be deleted or can be Gly-Arg or Gly-Lys or Arg or Lys 

<220>
<221>  misc_feature
<222>  (196)..(196)
<223>  Xaa can be Cys or Val or Ser

<220>
<221>  misc_feature
<222>  (212)..(213)
<223>  Xaa can be Ala-Ala or Ala-Gly or Gly-Ala or Gly-Gly

<220>
<221>  misc_feature
<222>  (215)..(216)
<223>  Xaa can be Ser-Ser or Ser-Gly or Gly-Ser or Gly-Gly

<220>
<221>  misc_feature
<222>  (225)..(225)
<223>  Xaa can be Gly or Tyr

<220>
<221>  misc_feature
<222>  (232)..(236)
<223>  Xaa232 can be Asn, Ser, Thr or Lys, Xaa233 can be Ser or Gly, Xaa234 can be Leu or Pro, Xaa235 can be Ala or Met, Xaa 236 can be Met or Val

<220>
<221>  misc_feature
<222>  (265)..(265)
<223>  Xaa can be Pro or Phe

<400>  6

Xaa Asp Asp Val Thr Cys Ser Ala Ser Glu Pro Thr Val Arg Ile Val 
1               5                   10                  15      


Gly Arg Xaa Gly Met Xaa Val Asp Val Arg Asp Asp Asp Phe His Asp 
            20                  25                  30          


Gly Asn Gln Ile Gln Leu Trp Pro Ser Lys Ser Asn Asn Asp Pro Asn 
        35                  40                  45              


Gln Leu Trp Thr Ile Lys Arg Asp Xaa Thr Ile Arg Ser Asn Gly Ser 
    50                  55                  60                  


Cys Leu Thr Thr Tyr Gly Tyr Thr Ala Gly Val Tyr Val Met Ile Phe 
65                  70                  75                  80  


Asp Cys Asn Thr Ala Val Arg Glu Ala Thr Ile Trp Gln Ile Trp Xaa 
                85                  90                  95      


Asn Gly Thr Ile Ile Asn Pro Arg Ser Asn Leu Val Leu Ala Ala Ser 
            100                 105                 110         


Ser Gly Ile Lys Gly Thr Thr Leu Thr Val Gln Thr Leu Asp Tyr Thr 
        115                 120                 125             


Leu Gly Gln Gly Trp Leu Ala Gly Asn Asp Thr Ala Pro Arg Glu Val 
    130                 135                 140                 


Thr Ile Tyr Gly Phe Arg Asp Leu Cys Met Glu Ser Asn Xaa Gly Ser 
145                 150                 155                 160 


Val Trp Val Glu Thr Cys Xaa Ser Ser Gln Xaa Asn Gln Xaa Xaa Trp 
                165                 170                 175     


Ala Leu Tyr Gly Asp Gly Ser Ile Arg Pro Lys Gln Asn Gln Asp Gln 
            180                 185                 190         


Cys Leu Thr Xaa Gly Arg Asp Ser Val Ser Thr Val Ile Asn Ile Val 
        195                 200                 205             


Ser Cys Ser Xaa Xaa Ser Xaa Xaa Gln Arg Trp Val Phe Thr Asn Glu 
    210                 215                 220                 


Xaa Ala Ile Leu Asn Leu Lys Xaa Xaa Xaa Xaa Xaa Asp Val Ala Gln 
225                 230                 235                 240 


Ala Asn Pro Lys Leu Arg Arg Ile Ile Ile Tyr Pro Ala Thr Gly Lys 
                245                 250                 255     


Pro Asn Gln Met Trp Leu Pro Val Xaa 
            260                 265 


<210>  7
<211>  264
<212>  PRT
<213>  Artificial

<220>
<223>  EP1051495 recombinant Protein


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be Met or can be deleted

<400>  7

Xaa Asp Asp Val Thr Cys Ser Ala Ser Glu Pro Thr Val Arg Ile Val 
1               5                   10                  15      


Gly Arg Asn Gly Met Cys Val Asp Val Arg Asp Asp Asp Phe His Asp 
            20                  25                  30          


Gly Asn Gln Ile Gln Leu Trp Pro Ser Lys Ser Asn Asn Asp Pro Asn 
        35                  40                  45              


Gln Leu Trp Thr Ile Lys Arg Asp Gly Thr Ile Arg Ser Asn Gly Ser 
    50                  55                  60                  


Cys Leu Thr Thr Tyr Gly Tyr Thr Ala Gly Val Tyr Val Met Ile Phe 
65                  70                  75                  80  


Asp Cys Asn Thr Ala Val Arg Glu Ala Thr Ile Trp Gln Ile Trp Gly 
                85                  90                  95      


Asn Gly Thr Ile Ile Asn Pro Arg Ser Asn Leu Val Leu Ala Ala Ser 
            100                 105                 110         


Ser Gly Ile Lys Gly Thr Thr Leu Thr Val Gln Thr Leu Asp Tyr Thr 
        115                 120                 125             


Leu Gly Gln Gly Trp Leu Ala Gly Asn Asp Thr Ala Pro Arg Glu Val 
    130                 135                 140                 


Thr Ile Tyr Gly Phe Arg Asp Leu Cys Met Glu Ser Asn Gly Gly Ser 
145                 150                 155                 160 


Val Trp Val Glu Thr Cys Val Ser Ser Gln Gln Asn Gln Arg Trp Ala 
                165                 170                 175     


Leu Tyr Gly Asp Gly Ser Ile Arg Pro Lys Gln Asn Gln Asp Gln Cys 
            180                 185                 190         


Leu Thr Cys Gly Arg Asp Ser Val Ser Thr Val Ile Asn Ile Val Ser 
        195                 200                 205             


Cys Ser Ala Gly Ser Ser Gly Gln Arg Trp Val Phe Thr Asn Glu Gly 
    210                 215                 220                 


Ala Ile Leu Asn Leu Lys Asn Gly Leu Ala Met Asp Val Ala Gln Ala 
225                 230                 235                 240 


Asn Pro Lys Leu Arg Arg Ile Ile Ile Tyr Pro Ala Thr Gly Lys Pro 
                245                 250                 255     


Asn Gln Met Trp Leu Pro Val Pro 
            260                 


<210>  8
<211>  265
<212>  PRT
<213>  Artificial

<220>
<223>  EP1051495 recombinant Protein


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be Met or can be deleted

<400>  8

Xaa Asp Asp Val Thr Cys Ser Ala Ser Glu Pro Thr Val Arg Ile Val 
1               5                   10                  15      


Gly Arg Asn Gly Met Arg Val Asp Val Arg Asp Asp Asp Phe His Asp 
            20                  25                  30          


Gly Asn Gln Ile Gln Leu Trp Pro Ser Lys Ser Asn Asn Asp Pro Asn 
        35                  40                  45              


Gln Leu Trp Thr Ile Lys Arg Asp Gly Thr Ile Arg Ser Asn Gly Ser 
    50                  55                  60                  


Cys Leu Thr Thr Tyr Gly Tyr Thr Ala Gly Val Tyr Val Met Ile Phe 
65                  70                  75                  80  


Asp Cys Asn Thr Ala Val Arg Glu Ala Thr Ile Trp Gln Ile Trp Asp 
                85                  90                  95      


Asn Gly Thr Ile Ile Asn Pro Arg Ser Asn Leu Val Leu Ala Ala Ser 
            100                 105                 110         


Ser Gly Ile Lys Gly Thr Thr Leu Thr Val Gln Thr Leu Asp Tyr Thr 
        115                 120                 125             


Leu Gly Gln Gly Trp Leu Ala Gly Asn Asp Thr Ala Pro Arg Glu Val 
    130                 135                 140                 


Thr Ile Tyr Gly Phe Arg Asp Leu Cys Met Glu Ser Asn Gly Gly Ser 
145                 150                 155                 160 


Val Trp Val Glu Thr Cys Asp Ser Ser Gln Lys Asn Gln Gly Lys Trp 
                165                 170                 175     


Ala Leu Tyr Gly Asp Gly Ser Ile Arg Pro Lys Gln Asn Gln Asp Gln 
            180                 185                 190         


Cys Leu Thr Ser Gly Arg Asp Ser Val Ser Thr Val Ile Asn Ile Val 
        195                 200                 205             


Ser Cys Ser Gly Ala Ser Gly Ser Gln Arg Trp Val Phe Thr Asn Glu 
    210                 215                 220                 


Gly Ala Ile Leu Asn Leu Lys Asn Gly Leu Ala Met Asp Val Ala Gln 
225                 230                 235                 240 


Ala Asn Pro Lys Leu Arg Arg Ile Ile Ile Tyr Pro Ala Thr Gly Lys 
                245                 250                 255     


Pro Asn Gln Met Trp Leu Pro Val Phe 
            260                 265 


<210>  9
<211>  265
<212>  PRT
<213>  Artificial

<220>
<223>  EP1051495 recombinant Protein


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be Met or can be deleted

<400>  9

Xaa Asp Asp Val Thr Cys Ser Ala Ser Glu Pro Thr Val Arg Ile Val 
1               5                   10                  15      


Gly Arg Ser Gly Met Arg Val Asp Val Arg Asp Asp Asp Phe His Asp 
            20                  25                  30          


Gly Asn Gln Ile Gln Leu Trp Pro Ser Lys Ser Asn Asn Asp Pro Asn 
        35                  40                  45              


Gln Leu Trp Thr Ile Lys Arg Asp Asn Thr Ile Arg Ser Asn Gly Ser 
    50                  55                  60                  


Cys Leu Thr Thr Tyr Gly Tyr Thr Ala Gly Val Tyr Val Met Ile Phe 
65                  70                  75                  80  


Asp Cys Asn Thr Ala Val Arg Glu Ala Thr Ile Trp Gln Ile Trp Asp 
                85                  90                  95      


Asn Gly Thr Ile Ile Asn Pro Arg Ser Asn Leu Val Leu Ala Ala Ser 
            100                 105                 110         


Ser Gly Ile Lys Gly Thr Thr Leu Thr Val Gln Thr Leu Asp Tyr Thr 
        115                 120                 125             


Leu Gly Gln Gly Trp Leu Ala Gly Asn Asp Thr Ala Pro Arg Glu Val 
    130                 135                 140                 


Thr Ile Tyr Gly Phe Arg Asp Leu Cys Met Glu Ser Asn Gln Gly Ser 
145                 150                 155                 160 


Val Trp Val Glu Thr Cys Asp Ser Ser Gln Lys Asn Gln Gly Lys Trp 
                165                 170                 175     


Ala Leu Tyr Gly Asp Gly Ser Ile Arg Pro Lys Gln Asn Gln Asp Gln 
            180                 185                 190         


Cys Leu Thr Val Gly Arg Asp Ser Val Ser Thr Val Ile Asn Ile Val 
        195                 200                 205             


Ser Cys Ser Gly Ala Ser Gly Ser Gln Arg Trp Val Phe Thr Asn Glu 
    210                 215                 220                 


Tyr Ala Ile Leu Asn Leu Lys Ser Gly Leu Ala Met Asp Val Ala Gln 
225                 230                 235                 240 


Ala Asn Pro Lys Leu Arg Arg Ile Ile Ile Tyr Pro Ala Thr Gly Lys 
                245                 250                 255     


Pro Asn Gln Met Trp Leu Pro Val Phe 
            260                 265 


<210>  10
<211>  265
<212>  PRT
<213>  Artificial

<220>
<223>  EP1051495 recombinant Protein


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be Met or can be deleted

<400>  10

Xaa Asp Asp Val Thr Cys Ser Ala Ser Glu Pro Thr Val Arg Ile Val 
1               5                   10                  15      


Gly Arg Asn Gly Met Arg Val Asp Val Arg Asp Asp Asp Phe His Asp 
            20                  25                  30          


Gly Asn Gln Ile Gln Leu Trp Pro Ser Lys Ser Asn Asn Asp Pro Asn 
        35                  40                  45              


Gln Leu Trp Thr Ile Lys Arg Asp Gly Thr Ile Arg Ser Asn Gly Ser 
    50                  55                  60                  


Cys Leu Thr Thr Tyr Gly Tyr Thr Ala Gly Val Tyr Val Met Ile Phe 
65                  70                  75                  80  


Asp Cys Asn Thr Ala Val Arg Glu Ala Thr Ile Trp Gln Ile Trp Asp 
                85                  90                  95      


Asn Gly Thr Ile Ile Asn Pro Arg Ser Asn Leu Val Leu Ala Ala Ser 
            100                 105                 110         


Ser Gly Ile Lys Gly Thr Thr Leu Thr Val Gln Thr Leu Asp Tyr Thr 
        115                 120                 125             


Leu Gly Gln Gly Trp Leu Ala Gly Asn Asp Thr Ala Pro Arg Glu Val 
    130                 135                 140                 


Thr Ile Tyr Gly Phe Arg Asp Leu Cys Met Glu Ser Asn Gly Gly Ser 
145                 150                 155                 160 


Val Trp Val Glu Thr Cys Asp Ser Ser Gln Lys Asn Gln Gly Lys Trp 
                165                 170                 175     


Ala Leu Tyr Gly Asp Gly Ser Ile Arg Pro Lys Gln Asn Gln Asp Gln 
            180                 185                 190         


Cys Leu Thr Ser Gly Arg Asp Ser Val Ser Thr Val Ile Asn Ile Val 
        195                 200                 205             


Ser Cys Ser Gly Ala Ser Gly Ser Gln Arg Trp Val Phe Thr Asn Glu 
    210                 215                 220                 


Gly Ala Ile Leu Asn Leu Lys Thr Gly Leu Ala Met Asp Val Ala Gln 
225                 230                 235                 240 


Ala Asn Pro Lys Leu Arg Arg Ile Ile Ile Tyr Pro Ala Thr Gly Lys 
                245                 250                 255     


Pro Asn Gln Met Trp Leu Pro Val Phe 
            260                 265 


<210>  11
<211>  265
<212>  PRT
<213>  Artificial

<220>
<223>  EP1051495 recombinant Protein


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be Met or can be deleted

<400>  11

Xaa Asp Asp Val Thr Cys Ser Ala Ser Glu Pro Thr Val Arg Ile Val 
1               5                   10                  15      


Gly Arg Asn Gly Met Arg Val Asp Val Arg Asp Asp Asp Phe His Asp 
            20                  25                  30          


Gly Asn Gln Ile Gln Leu Trp Pro Ser Lys Ser Asn Asn Asp Pro Asn 
        35                  40                  45              


Gln Leu Trp Thr Ile Lys Arg Asp Gly Thr Ile Arg Ser Asn Gly Ser 
    50                  55                  60                  


Cys Leu Thr Thr Tyr Gly Tyr Thr Ala Gly Val Tyr Val Met Ile Phe 
65                  70                  75                  80  


Asp Cys Asn Thr Ala Val Arg Glu Ala Thr Ile Trp Gln Ile Trp Asp 
                85                  90                  95      


Asn Gly Thr Ile Ile Asn Pro Arg Ser Asn Leu Val Leu Ala Ala Ser 
            100                 105                 110         


Ser Gly Ile Lys Gly Thr Thr Leu Thr Val Gln Thr Leu Asp Tyr Thr 
        115                 120                 125             


Leu Gly Gln Gly Trp Leu Ala Gly Asn Asp Thr Ala Pro Arg Glu Val 
    130                 135                 140                 


Thr Ile Tyr Gly Phe Arg Asp Leu Cys Met Glu Ser Asn Gly Gly Ser 
145                 150                 155                 160 


Val Trp Val Glu Thr Cys Asp Ser Ser Gln Lys Asn Gln Gly Lys Trp 
                165                 170                 175     


Ala Leu Tyr Gly Asp Gly Ser Ile Arg Pro Lys Gln Asn Gln Asp Gln 
            180                 185                 190         


Cys Leu Thr Ser Gly Arg Asp Ser Val Ser Thr Val Ile Asn Ile Val 
        195                 200                 205             


Ser Cys Ser Gly Ala Ser Gly Ser Gln Arg Trp Val Phe Thr Asn Glu 
    210                 215                 220                 


Gly Ala Ile Leu Asn Leu Lys Lys Gly Pro Ala Met Asp Val Ala Gln 
225                 230                 235                 240 


Ala Asn Pro Lys Leu Arg Arg Ile Ile Ile Tyr Pro Ala Thr Gly Lys 
                245                 250                 255     


Pro Asn Gln Met Trp Leu Pro Val Phe 
            260                 265 


<210>  12
<211>  265
<212>  PRT
<213>  Artificial

<220>
<223>  EP1051495 recombinant Protein


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be Met or can be deleted

<400>  12

Xaa Asp Asp Val Thr Cys Ser Ala Ser Glu Pro Thr Val Arg Ile Val 
1               5                   10                  15      


Gly Arg Asn Gly Met Arg Val Asp Val Arg Asp Asp Asp Phe His Asp 
            20                  25                  30          


Gly Asn Gln Ile Gln Leu Trp Pro Ser Lys Ser Asn Asn Asp Pro Asn 
        35                  40                  45              


Gln Leu Trp Thr Ile Lys Arg Asp Gly Thr Ile Arg Ser Asn Gly Ser 
    50                  55                  60                  


Cys Leu Thr Thr Tyr Gly Tyr Thr Ala Gly Val Tyr Val Met Ile Phe 
65                  70                  75                  80  


Asp Cys Asn Thr Ala Val Arg Glu Ala Thr Ile Trp Gln Ile Trp Asp 
                85                  90                  95      


Asn Gly Thr Ile Ile Asn Pro Arg Ser Asn Leu Val Leu Ala Ala Ser 
            100                 105                 110         


Ser Gly Ile Lys Gly Thr Thr Leu Thr Val Gln Thr Leu Asp Tyr Thr 
        115                 120                 125             


Leu Gly Gln Gly Trp Leu Ala Gly Asn Asp Thr Ala Pro Arg Glu Val 
    130                 135                 140                 


Thr Ile Tyr Gly Phe Arg Asp Leu Cys Met Glu Ser Asn Gly Gly Ser 
145                 150                 155                 160 


Val Trp Val Glu Thr Cys Asp Ser Ser Gln Lys Asn Gln Gly Lys Trp 
                165                 170                 175     


Ala Leu Tyr Gly Asp Gly Ser Ile Arg Pro Lys Gln Asn Gln Asp Gln 
            180                 185                 190         


Cys Leu Thr Ser Gly Arg Asp Ser Val Ser Thr Val Ile Asn Ile Val 
        195                 200                 205             


Ser Cys Ser Gly Ala Ser Gly Ser Gln Arg Trp Val Phe Thr Asn Glu 
    210                 215                 220                 


Gly Ala Ile Leu Asn Leu Lys Asn Ser Leu Met Val Asp Val Ala Gln 
225                 230                 235                 240 


Ala Asn Pro Lys Leu Arg Arg Ile Ile Ile Tyr Pro Ala Thr Gly Lys 
                245                 250                 255     


Pro Asn Gln Met Trp Leu Pro Val Phe 
            260                 265 


