                         SEQUENCE LISTING

<110>  Genmab A/S
 
<120>  HUMAN ANTIBODIES AGAINST CD74

<130>  P68

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial sequence

<400>  1

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                 170                 175     


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         


Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                 200                 205             


Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His 
    210                 215                 220                 


Pro Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro 
225                 230                 235                 240 


Leu Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn 
                245                 250                 255     


Gly Thr Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser 
            260                 265                 270         


Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
        275                 280                 285             


Gln Asp Leu Gly Pro Val Pro Met 
    290                 295     


<210>  2
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Partial sequence

<400>  2

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                 170                 175     


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         


Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                 200                 205             


Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
    210                 215                 220                 


Gln Asp Leu Gly Pro Val Pro Met 
225                 230         


<210>  3
<211>  261
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Partial sequence

<400>  3

Met Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala Leu Tyr Thr 
1               5                   10                  15      


Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln Ala Thr Thr 
            20                  25                  30          


Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys Leu Thr Val 
        35                  40                  45              


Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys Leu Pro Lys 
    50                  55                  60                  


Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro Leu Leu Met 
65                  70                  75                  80  


Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met Gln Asn Ala 
                85                  90                  95      


Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His Leu Leu Gln 
            100                 105                 110         


Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly Ser Phe Pro 
        115                 120                 125             


Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile Asp Trp Lys 
    130                 135                 140                 


Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu Met Ser Arg 
145                 150                 155                 160 


His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys Val Leu Thr 
                165                 170                 175     


Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His Pro Gly Ser 
            180                 185                 190         


Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro Leu Gln Cys 
        195                 200                 205             


Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn Gly Thr Glu 
    210                 215                 220                 


Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser Glu Ser Leu 
225                 230                 235                 240 


Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys Gln Asp Leu 
                245                 250                 255     


Gly Pro Val Pro Met 
            260     


<210>  4
<211>  197
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Partial sequence

<400>  4

Met Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala Leu Tyr Thr 
1               5                   10                  15      


Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln Ala Thr Thr 
            20                  25                  30          


Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys Leu Thr Val 
        35                  40                  45              


Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys Leu Pro Lys 
    50                  55                  60                  


Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro Leu Leu Met 
65                  70                  75                  80  


Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met Gln Asn Ala 
                85                  90                  95      


Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His Leu Leu Gln 
            100                 105                 110         


Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly Ser Phe Pro 
        115                 120                 125             


Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile Asp Trp Lys 
    130                 135                 140                 


Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu Met Ser Arg 
145                 150                 155                 160 


His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys Glu Ser Leu 
                165                 170                 175     


Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys Gln Asp Leu 
            180                 185                 190         


Gly Pro Val Pro Met 
        195         


<210>  5
<211>  230
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Partial sequence with His-tag

<400>  5

His His His His His His Gln Gln Gln Gly Arg Leu Asp Lys Leu Thr 
1               5                   10                  15      


Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys Leu Pro 
            20                  25                  30          


Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro Leu Leu 
        35                  40                  45              


Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met Gln Asn 
    50                  55                  60                  


Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His Leu Leu 
65                  70                  75                  80  


Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly Ser Phe 
                85                  90                  95      


Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile Asp Trp 
            100                 105                 110         


Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu Met Ser 
        115                 120                 125             


Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys Val Leu 
    130                 135                 140                 


Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His Pro Gly 
145                 150                 155                 160 


Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro Leu Gln 
                165                 170                 175     


Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn Gly Thr 
            180                 185                 190         


Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser Glu Ser 
        195                 200                 205             


Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys Gln Asp 
    210                 215                 220                 


Leu Gly Pro Val Pro Met 
225                 230 


<210>  6
<211>  166
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Partial sequence with His-tag

<400>  6

His His His His His His Gln Gln Gln Gly Arg Leu Asp Lys Leu Thr 
1               5                   10                  15      


Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys Leu Pro 
            20                  25                  30          


Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro Leu Leu 
        35                  40                  45              


Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met Gln Asn 
    50                  55                  60                  


Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His Leu Leu 
65                  70                  75                  80  


Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly Ser Phe 
                85                  90                  95      


Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile Asp Trp 
            100                 105                 110         


Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu Met Ser 
        115                 120                 125             


Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys Glu Ser 
    130                 135                 140                 


Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys Gln Asp 
145                 150                 155                 160 


Leu Gly Pro Val Pro Met 
                165     


<210>  7
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Arg Tyr Tyr Gly Ser Gly Ser Tyr Ser Ser Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  8
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  9

Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  10
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Ser Gly Arg Tyr Tyr Gly Ser Gly Ser Tyr Ser Ser Tyr Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  11
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  11

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Phe Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Glu Ile Thr Ser Gln Asn Ile Val Ile Leu Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Thr Ser 
        115                 120                 


<210>  12
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  12

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  13

Ile Ser Tyr Asp Gly Ser Ile Lys 
1               5               


<210>  14
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Arg Gly Arg Glu Ile Thr Ser Gln Asn Ile Val Ile Leu Leu Asp 
1               5                   10                  15      


Tyr 
    


<210>  15
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  15

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Glu Ile Thr Ser Gln Asn Ile Val Ile Leu Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  16
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  16

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  17

Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  18
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Arg Gly Arg Glu Ile Thr Ser Gln Asn Ile Val Ile Leu Leu Asp 
1               5                   10                  15      


Tyr 
    


<210>  19
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  19

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Leu Val Arg Gly Ala Met Tyr Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  20
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  21

Ile Trp Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  22
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Arg Gly Gly Thr Leu Val Arg Gly Ala Met Tyr Gly Thr Asp Val 
1               5                   10                  15      


<210>  23
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  24
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Gly Ile Ser Ser Trp 
1               5       


<210>  25
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  25

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  26
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


