                         SEQUENCE LISTING

<110>  Basilea Pharmaceutica AG
 
<120>  Use of Stathmin as a biomarker of drug response

<130>  P40414EP00

<160>  6     

<170>  PatentIn version 3.4

<210>  1
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ser Ser Asp Ile Gln Val Lys Glu Leu Glu Lys Arg Ala Ser 
1               5                   10                  15      


Gly Gln Ala Phe Glu Leu Ile Leu Ser Pro Arg Ser Lys Glu Ser Val 
            20                  25                  30          


Pro Glu Phe Pro Leu Ser Pro Pro Lys Lys Lys Asp Leu Ser Leu Glu 
        35                  40                  45              


Glu Ile Gln Lys Lys Leu Glu Ala Ala Glu Glu Arg Arg Lys Ser His 
    50                  55                  60                  


Glu Ala Glu Val Leu Lys Gln Leu Ala Glu Lys Arg Glu His Glu Lys 
65                  70                  75                  80  


Glu Val Leu Gln Lys Ala Ile Glu Glu Asn Asn Asn Phe Ser Lys Met 
                85                  90                  95      


Ala Glu Glu Lys Leu Thr His Lys Met Glu Ala Asn Lys Glu Asn Arg 
            100                 105                 110         


Glu Ala Gln Met Ala Ala Lys Leu Glu Arg Leu Arg Glu Lys Asp Lys 
        115                 120                 125             


His Ile Glu Glu Val Arg Lys Asn Lys Glu Ser Lys Asp Pro Ala Asp 
    130                 135                 140                 


Glu Thr Glu Ala Asp 
145                 


<210>  2
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Ser Asp Ile Gln Val Lys Glu Leu Glu Lys Arg Ala Ser 
1               5                   10                  15      


Gly Gln Ala Phe Glu Leu Ile Leu Ser Pro Arg Ser Lys Glu Ser Val 
            20                  25                  30          


Pro Glu Phe Pro Leu Ser Pro Pro Lys Lys Lys Asp Leu Ser Leu Glu 
        35                  40                  45              


Glu Ile Gln Lys Lys Leu Glu Ala Ala Glu Glu Arg Arg Lys Ser His 
    50                  55                  60                  


Glu Ala Glu Val Leu Lys Gln Leu Ala Glu Lys Arg Glu His Glu Lys 
65                  70                  75                  80  


Glu Val Leu Gln Lys Ala Ile Glu Glu Asn Asn Asn Phe Ser Lys Met 
                85                  90                  95      


Ala Glu Glu Lys Leu Thr His Lys Met Glu Ala Asn Lys Glu Asn Arg 
            100                 105                 110         


Glu Ala Gln Met Ala Ala Lys Leu Glu Arg Leu Arg Glu Lys Met Tyr 
        115                 120                 125             


Phe Trp Thr His Gly Pro Gly Ala His Pro Ala Gln Ile Ser Ala Glu 
    130                 135                 140                 


Gln Ser Cys Leu His Ser Val Pro Ala Leu Cys Pro Ala Leu Gly Leu 
145                 150                 155                 160 


Gln Ser Ala Leu Ile Thr Trp Ser Asp Leu Ser His His His 
                165                 170                 


<210>  3
<211>  1542
<212>  DNA
<213>  Homo sapiens

<400>  3
gctctcggcc aatgcggagc cccgcgcgga ggtcacgtgc ctctgtttgg cgcttttgtg     60

cgcgcccggg tctgttggtg ctcagagtgt ggtcaggcgg ctcggactga gcaggacttt    120

ccttatccca gttgattgtg cagaatacac tgcctgtcgc ttgtcttcta ttcaccatgg    180

cttcttctga tatccaggtg aaagaactgg agaagcgtgc ctcaggccag gcttttgagc    240

tgattctcag ccctcggtca aaagaatctg ttccagaatt ccccctttcc cctccaaaga    300

agaaggatct ttccctggag gaaattcaga agaaattaga agctgcagaa gaaagacgca    360

agtcccatga agctgaggtc ttgaagcagc tggctgagaa acgagagcac gagaaagaag    420

tgcttcagaa ggcaatagaa gagaacaaca acttcagtaa aatggcagaa gagaaactga    480

cccacaaaat ggaagctaat aaagagaacc gagaggcaca aatggctgcc aaactggaac    540

gtttgcgaga gaaggataag cacattgaag aagtgcggaa gaacaaagaa tccaaagacc    600

ctgctgacga gactgaagct gactaatttg ttctgagaac tgactttctc cccatcccct    660

tcctaaatat ccaaagactg tactggccag tgtcatttta ttttttccct cctgacaaat    720

attttagaag ctaatgtagg actgtatagg tagatccaga tccagactgt aagatgttgt    780

tttaggggct aaaggggaga aactgaaagt gttttactct ttttctaaag tgttggtctt    840

tctaatgtag ctatttttct tgttgcatct tttctacttc agtacacttg gtgtactggg    900

ttaatggcta gtactgtatt ggctctgtga aaacatattt gtgaaaagag tatgtagtgg    960

cttcttttga actgttagat gctgaatatc tgttcacttt tcaatcccaa ttctgtccca   1020

atcttaccag atgctactgg acttgaatgg ttaataaaac tgcacagtgc tgttggtggc   1080

agtgacttct tttgagttag gttaataaat caagccatag agcccctcct ggttgatact   1140

tgttccagat ggggcctttg gggctggtag aaatacccaa cgcacaaatg accgcacgtt   1200

ctctgccccg tttcttgccc cagtgtggtt tgcattgtct ccttccacaa tgactgcttt   1260

gtttggatgc ctcagcccag gtcagctgtt actttctttc agatgtttat ttgcaaacaa   1320

ccattttttg ttctgtgtcc cttttaaaag gcagattaaa agcacaagcg tgtttctaga   1380

gaacagttga gagagaatct caagattcta cttggtggtt tgcttgctct acgttacagg   1440

tggggcatgt cctcatcctt tcctgccata aaagctatga cacgagaatc agaatattaa   1500

taaaacttta tgtactgctg tagcaaaaaa aaaaaaaaaa aa                      1542


<210>  4
<211>  1518
<212>  DNA
<213>  Homo sapiens

<400>  4
aggggcactg ctctgtccga gtgctgccct tggggcgagg cgggcatgtg gctctacaag     60

gtggagtcca ggcggccaaa gtttggaaag gactttcctt atcccagttg attgtgcaga    120

atacactgcc tgtcgcttgt cttctattca ccatggcttc ttctgatatc caggtgaaag    180

aactggagaa gcgtgcctca ggccaggctt ttgagctgat tctcagccct cggtcaaaag    240

aatctgttcc agaattcccc ctttcccctc caaagaagaa ggatctttcc ctggaggaaa    300

ttcagaagaa attagaagct gcagaagaaa gacgcaagtc ccatgaagct gaggtcttga    360

agcagctggc tgagaaacga gagcacgaga aagaagtgct tcagaaggca atagaagaga    420

acaacaactt cagtaaaatg gcagaagaga aactgaccca caaaatggaa gctaataaag    480

agaaccgaga ggcacaaatg gctgccaaac tggaacgttt gcgagagaag gataagcaca    540

ttgaagaagt gcggaagaac aaagaatcca aagaccctgc tgacgagact gaagctgact    600

aatttgttct gagaactgac tttctcccca tccccttcct aaatatccaa agactgtact    660

ggccagtgtc attttatttt ttccctcctg acaaatattt tagaagctaa tgtaggactg    720

tataggtaga tccagatcca gactgtaaga tgttgtttta ggggctaaag gggagaaact    780

gaaagtgttt tactcttttt ctaaagtgtt ggtctttcta atgtagctat ttttcttgtt    840

gcatcttttc tacttcagta cacttggtgt actgggttaa tggctagtac tgtattggct    900

ctgtgaaaac atatttgtga aaagagtatg tagtggcttc ttttgaactg ttagatgctg    960

aatatctgtt cacttttcaa tcccaattct gtcccaatct taccagatgc tactggactt   1020

gaatggttaa taaaactgca cagtgctgtt ggtggcagtg acttcttttg agttaggtta   1080

ataaatcaag ccatagagcc cctcctggtt gatacttgtt ccagatgggg cctttggggc   1140

tggtagaaat acccaacgca caaatgaccg cacgttctct gccccgtttc ttgccccagt   1200

gtggtttgca ttgtctcctt ccacaatgac tgctttgttt ggatgcctca gcccaggtca   1260

gctgttactt tctttcagat gtttatttgc aaacaaccat tttttgttct gtgtcccttt   1320

taaaaggcag attaaaagca caagcgtgtt tctagagaac agttgagaga gaatctcaag   1380

attctacttg gtggtttgct tgctctacgt tacaggtggg gcatgtcctc atcctttcct   1440

gccataaaag ctatgacacg agaatcagaa tattaataaa actttatgta ctgctgtagc   1500

aaaaaaaaaa aaaaaaaa                                                 1518


<210>  5
<211>  1730
<212>  DNA
<213>  Homo sapiens

<400>  5
atcaccgggc gtccgctccg gggtgccgtc gaggagacaa tagggggcgt gggccctcgt     60

ttacctccct ccctccctcc cttccctgcg ggccccgccg ggttccccat tgtctgaagg    120

gacggggcgg tgccccaggg accagcggct ttaggaccaa actgcgggca gccagggccg    180

cgaccctccc tgcgaccgtc ccctggcgac cgcagctggt gattgagggg cggcgctccc    240

gggccccacg agggttcttc tgtcttcgcg gccggacgcg cggacagcgt gggtggcggc    300

aggactttcc ttatcccagt tgattgtgca gaatacactg cctgtcgctt gtcttctatt    360

caccatggct tcttctgata tccaggtgaa agaactggag aagcgtgcct caggccaggc    420

ttttgagctg attctcagcc ctcggtcaaa agaatctgtt ccagaattcc ccctttcccc    480

tccaaagaag aaggatcttt ccctggagga aattcagaag aaattagaag ctgcagaaga    540

aagacgcaag tcccatgaag ctgaggtctt gaagcagctg gctgagaaac gagagcacga    600

gaaagaagtg cttcagaagg caatagaaga gaacaacaac ttcagtaaaa tggcagaaga    660

gaaactgacc cacaaaatgg aagctaataa agagaaccga gaggcacaaa tggctgccaa    720

actggaacgt ttgcgagaga aggataagca cattgaagaa gtgcggaaga acaaagaatc    780

caaagaccct gctgacgaga ctgaagctga ctaatttgtt ctgagaactg actttctccc    840

catccccttc ctaaatatcc aaagactgta ctggccagtg tcattttatt ttttccctcc    900

tgacaaatat tttagaagct aatgtaggac tgtataggta gatccagatc cagactgtaa    960

gatgttgttt taggggctaa aggggagaaa ctgaaagtgt tttactcttt ttctaaagtg   1020

ttggtctttc taatgtagct atttttcttg ttgcatcttt tctacttcag tacacttggt   1080

gtactgggtt aatggctagt actgtattgg ctctgtgaaa acatatttgt gaaaagagta   1140

tgtagtggct tcttttgaac tgttagatgc tgaatatctg ttcacttttc aatcccaatt   1200

ctgtcccaat cttaccagat gctactggac ttgaatggtt aataaaactg cacagtgctg   1260

ttggtggcag tgacttcttt tgagttaggt taataaatca agccatagag cccctcctgg   1320

ttgatacttg ttccagatgg ggcctttggg gctggtagaa atacccaacg cacaaatgac   1380

cgcacgttct ctgccccgtt tcttgcccca gtgtggtttg cattgtctcc ttccacaatg   1440

actgctttgt ttggatgcct cagcccaggt cagctgttac tttctttcag atgtttattt   1500

gcaaacaacc attttttgtt ctgtgtccct tttaaaaggc agattaaaag cacaagcgtg   1560

tttctagaga acagttgaga gagaatctca agattctact tggtggtttg cttgctctac   1620

gttacaggtg gggcatgtcc tcatcctttc ctgccataaa agctatgaca cgagaatcag   1680

aatattaata aaactttatg tactgctgta gcaaaaaaaa aaaaaaaaaa              1730


<210>  6
<211>  2265
<212>  DNA
<213>  Homo sapiens

<400>  6
gctctcggcc aatgcggagc cccgcgcgga ggtcacgtgc ctctgtttgg cgcttttgtg     60

cgcgcccggg tctgttggtg ctcagagtgt ggtcaggcgg ctcggactga gcaggacttt    120

ccttatccca gttgattgtg cagaatacac tgcctgtcgc ttgtcttcta ttcaccatgg    180

cttcttctga tatccaggtg aaagaactgg agaagcgtgc ctcaggccag gcttttgagc    240

tgattctcag ccctcggtca aaagaatctg ttccagaatt ccccctttcc cctccaaaga    300

agaaggatct ttccctggag gaaattcaga agaaattaga agctgcagaa gaaagacgca    360

agtcccatga agctgaggtc ttgaagcagc tggctgagaa acgagagcac gagaaagaag    420

tgcttcagaa ggcaatagaa gagaacaaca acttcagtaa aatggcagaa gagaaactga    480

cccacaaaat ggaagctaat aaagagaacc gagaggcaca aatggctgcc aaactggaac    540

gtttgcgaga gaagatgtac ttctggactc acgggcctgg ggcccaccca gcacagatct    600

ctgctgagca atcttgtctc cactctgttc ctgccctttg cccagccctg ggcctccaat    660

ctgcattgat tacctggtct gatctctctc accatcacta ggtacttaat aaatatttgc    720

tgttgatgat agcaatgacc ttgagactga tgaacagtct ggccaagagg atccttgatg    780

tggaagatag aaaaagcctt tggggtcagg cagacttgga ttctaatacc agccagttct    840

gcttgctgtg tctgagcctc agtttactca tctgtgaaga ggaggtagca agaatgaaaa    900

tgcctgcctt gtggtttgtt gtaaggacag acactgccaa cgtagagggc ccagcagctc    960

acagaccagt tgctctgaga gcagaccact cttgccttga tggtagggaa ctatttttgt   1020

gcgtggcaag tgggacctta ggaaggaagg caactgtgag gcttctgaga aggaccctac   1080

acaagggagt ttcctcccag ggcaggtgaa tggagagggt ggcagaagcc tacgggaagg   1140

ggtcacaggg atcagctaga gagtgccacc acccttcctg gggaatgcag ggcaaggtcc   1200

ctggtgggag ttttcctggg aagccaaaga agcgcccaac aaagacagaa tcaacatttg   1260

ggtacctttg gtacccagag gcagcaatgc caactacaac cacactggaa gaagaagacc   1320

ttctccgcat agattctctg atctcttcct ccttcatggc accagccctg gggaaccagc   1380

atggtgggga aataatgaag ctggaataca accacttaca gacttcacaa cctcctcctg   1440

tagataccaa agggatttta ggatcacatt ttatttctca cctgagcaag aaaagctaca   1500

ggagcatctc aagcagaggg caggagtctc cagaggagtt caaggggctc tggcaagaaa   1560

aatcaagggg ctgtgttcaa gaactggctc ccttggtgat tgtattacga agcccatgtg   1620

tgctggatgc tgatgaaatt gctgccaaat gcctgtgcag ccttggcaag gccctttatt   1680

tctctgggtc tccatttctc tctctctttt tttttttttt ttttttttga ggcagagtct   1740

cactctgtcg cccaggctgg agggcagtgg cgtgatctcg gctcactgca agccccacct   1800

tctgagttca cgccattcta ctgcctcagc ctcccgagta gctgggacta caggcgccca   1860

ccaccacgcc cggcttattt tttgtatttt tagtagagac ggggtttcac cgcattagcc   1920

aagatggtct cgatctcctg acctcgtgat tcacccacct cagcctccca aagtgctggg   1980

attacaggca tgagccactg cgcccggcct gggtctccgt ttctctagct gtgaaatgac   2040

tgttctaaaa gagccctgcc ggactttggc agtctgtaag aagacctgag ttcttctctc   2100

agttccaagc aggaaaattg aacataccct gagcccagag cctgcaacaa actctgggca   2160

gcctcaggaa gtcaggcagt gaagtcggaa aaatgatctc ttctgtatag ggagaaaata   2220

aaagtttaaa aatttgtaaa aaaaaaaaaa agaaaaaaaa aaaaa                   2265


