                         SEQUENCE LISTING

<110>  Kappa Biosystems
       Paul McEwan
       Eric van der Walt
       John Foskett
       Wolfgang Schafer
       William Bourn
 
<120>  Modified DNA Polymerases for Improved Amplification

<130>  2006735-0038

<150>  US 61/432,936
<151>  2011-01-14

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  832
<212>  PRT
<213>  Thermus aquaticus

<400>  1

Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      


Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          


Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              


Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  


Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  


Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      


Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         


Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             


Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 


Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 


Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     


Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         


Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             


Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 


Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 


Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     


Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         


Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             


Glu Ser Pro Lys Ala Leu Glu Glu Ala Pro Trp Pro Pro Pro Glu Gly 
    290                 295                 300                 


Ala Phe Val Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp 
305                 310                 315                 320 


Leu Leu Ala Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro 
                325                 330                 335     


Glu Pro Tyr Lys Ala Leu Arg Asp Leu Lys Glu Ala Arg Gly Leu Leu 
            340                 345                 350         


Ala Lys Asp Leu Ser Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro 
        355                 360                 365             


Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn 
    370                 375                 380                 


Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu 
385                 390                 395                 400 


Glu Ala Gly Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asn Leu 
                405                 410                 415     


Trp Gly Arg Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu Tyr Arg Glu 
            420                 425                 430         


Val Glu Arg Pro Leu Ser Ala Val Leu Ala His Met Glu Ala Thr Gly 
        435                 440                 445             


Val Arg Leu Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala 
    450                 455                 460                 


Glu Glu Ile Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His 
465                 470                 475                 480 


Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp 
                485                 490                 495     


Glu Leu Gly Leu Pro Ala Ile Gly Lys Thr Glu Lys Thr Gly Lys Arg 
            500                 505                 510         


Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile 
        515                 520                 525             


Val Glu Lys Ile Leu Gln Tyr Arg Glu Leu Thr Lys Leu Lys Ser Thr 
    530                 535                 540                 


Tyr Ile Asp Pro Leu Pro Asp Leu Ile His Pro Arg Thr Gly Arg Leu 
545                 550                 555                 560 


His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser 
                565                 570                 575     


Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln 
            580                 585                 590         


Arg Ile Arg Arg Ala Phe Ile Ala Glu Glu Gly Trp Leu Leu Val Ala 
        595                 600                 605             


Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly 
    610                 615                 620                 


Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Arg Asp Ile His Thr 
625                 630                 635                 640 


Glu Thr Ala Ser Trp Met Phe Gly Val Pro Arg Glu Ala Val Asp Pro 
                645                 650                 655     


Leu Met Arg Arg Ala Ala Lys Thr Ile Asn Phe Gly Val Leu Tyr Gly 
            660                 665                 670         


Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr Glu Glu 
        675                 680                 685             


Ala Gln Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys Val Arg 
    690                 695                 700                 


Ala Trp Ile Glu Lys Thr Leu Glu Glu Gly Arg Arg Arg Gly Tyr Val 
705                 710                 715                 720 


Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Glu Ala Arg 
                725                 730                 735     


Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn Met Pro 
            740                 745                 750         


Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Lys Leu 
        755                 760                 765             


Phe Pro Arg Leu Glu Glu Met Gly Ala Arg Met Leu Leu Gln Val His 
    770                 775                 780                 


Asp Glu Leu Val Leu Glu Ala Pro Lys Glu Arg Ala Glu Ala Val Ala 
785                 790                 795                 800 


Arg Leu Ala Lys Glu Val Met Glu Gly Val Tyr Pro Leu Ala Val Pro 
                805                 810                 815     


Leu Glu Val Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Glu 
            820                 825                 830         


<210>  2
<211>  834
<212>  PRT
<213>  Thermus thermophilus HB8

<400>  2

Met Glu Ala Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      


Val Asp Gly His His Leu Ala Tyr Arg Thr Phe Phe Ala Leu Lys Gly 
            20                  25                  30          


Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              


Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Tyr Lys Ala Val Phe 
    50                  55                  60                  


Val Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Glu 
65                  70                  75                  80  


Ala Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln 
                85                  90                  95      


Leu Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Phe Thr Arg Leu 
            100                 105                 110         


Glu Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Thr Leu Ala Lys 
        115                 120                 125             


Lys Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Arg 
    130                 135                 140                 


Asp Leu Tyr Gln Leu Val Ser Asp Arg Val Ala Val Leu His Pro Glu 
145                 150                 155                 160 


Gly His Leu Ile Thr Pro Glu Trp Leu Trp Glu Lys Tyr Gly Leu Arg 
                165                 170                 175     


Pro Glu Gln Trp Val Asp Phe Arg Ala Leu Val Gly Asp Pro Ser Asp 
            180                 185                 190         


Asn Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Leu Lys Leu 
        195                 200                 205             


Leu Lys Glu Trp Gly Ser Leu Glu Asn Leu Leu Lys Asn Leu Asp Arg 
    210                 215                 220                 


Val Lys Pro Glu Asn Val Arg Glu Lys Ile Lys Ala His Leu Glu Asp 
225                 230                 235                 240 


Leu Arg Leu Ser Leu Glu Leu Ser Arg Val Arg Thr Asp Leu Pro Leu 
                245                 250                 255     


Glu Val Asp Leu Ala Gln Gly Arg Glu Pro Asp Arg Glu Gly Leu Arg 
            260                 265                 270         


Ala Phe Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly 
        275                 280                 285             


Leu Leu Glu Ala Pro Ala Pro Leu Glu Glu Ala Pro Trp Pro Pro Pro 
    290                 295                 300                 


Glu Gly Ala Phe Val Gly Phe Val Leu Ser Arg Pro Glu Pro Met Trp 
305                 310                 315                 320 


Ala Glu Leu Lys Ala Leu Ala Ala Cys Arg Asp Gly Arg Val His Arg 
                325                 330                 335     


Ala Ala Asp Pro Leu Ala Gly Leu Lys Asp Leu Lys Glu Val Arg Gly 
            340                 345                 350         


Leu Leu Ala Lys Asp Leu Ala Val Leu Ala Ser Arg Glu Gly Leu Asp 
        355                 360                 365             


Leu Val Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro 
    370                 375                 380                 


Ser Asn Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp 
385                 390                 395                 400 


Thr Glu Asp Ala Ala His Arg Ala Leu Leu Ser Glu Arg Leu His Arg 
                405                 410                 415     


Asn Leu Leu Lys Arg Leu Glu Gly Glu Glu Lys Leu Leu Trp Leu Tyr 
            420                 425                 430         


His Glu Val Glu Lys Pro Leu Ser Arg Val Leu Ala His Met Glu Ala 
        435                 440                 445             


Thr Gly Val Arg Leu Asp Val Ala Tyr Leu Gln Ala Leu Ser Leu Glu 
    450                 455                 460                 


Leu Ala Glu Glu Ile Arg Arg Leu Glu Glu Glu Val Phe Arg Leu Ala 
465                 470                 475                 480 


Gly His Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu 
                485                 490                 495     


Phe Asp Glu Leu Arg Leu Pro Ala Leu Gly Lys Thr Gln Lys Thr Gly 
            500                 505                 510         


Lys Arg Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His 
        515                 520                 525             


Pro Ile Val Glu Lys Ile Leu Gln His Arg Glu Leu Thr Lys Leu Lys 
    530                 535                 540                 


Asn Thr Tyr Val Asp Pro Leu Pro Ser Leu Val His Pro Arg Thr Gly 
545                 550                 555                 560 


Arg Leu His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu 
                565                 570                 575     


Ser Ser Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu 
            580                 585                 590         


Gly Gln Arg Ile Arg Arg Ala Phe Val Ala Glu Ala Gly Trp Ala Leu 
        595                 600                 605             


Val Ala Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu 
    610                 615                 620                 


Ser Gly Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Lys Asp Ile 
625                 630                 635                 640 


His Thr Gln Thr Ala Ser Trp Met Phe Gly Val Pro Pro Glu Ala Val 
                645                 650                 655     


Asp Pro Leu Met Arg Arg Ala Ala Lys Thr Val Asn Phe Gly Val Leu 
            660                 665                 670         


Tyr Gly Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr 
        675                 680                 685             


Glu Glu Ala Val Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys 
    690                 695                 700                 


Val Arg Ala Trp Ile Glu Lys Thr Leu Glu Glu Gly Arg Lys Arg Gly 
705                 710                 715                 720 


Tyr Val Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Asn 
                725                 730                 735     


Ala Arg Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn 
            740                 745                 750         


Met Pro Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val 
        755                 760                 765             


Lys Leu Phe Pro Arg Leu Arg Glu Met Gly Ala Arg Met Leu Leu Gln 
    770                 775                 780                 


Val His Asp Glu Leu Leu Leu Glu Ala Pro Gln Ala Arg Ala Glu Glu 
785                 790                 795                 800 


Val Ala Ala Leu Ala Lys Glu Ala Met Glu Lys Ala Tyr Pro Leu Ala 
                805                 810                 815     


Val Pro Leu Glu Val Glu Val Gly Met Gly Glu Asp Trp Leu Ser Ala 
            820                 825                 830         


Lys Gly 
        


<210>  3
<211>  834
<212>  PRT
<213>  Thermus caldophilus

<400>  3

Met Glu Ala Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      


Val Asp Gly His His Leu Ala Tyr Arg Thr Phe Phe Ala Leu Lys Gly 
            20                  25                  30          


Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              


Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Tyr Lys Ala Val Phe 
    50                  55                  60                  


Val Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Glu 
65                  70                  75                  80  


Ala Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln 
                85                  90                  95      


Leu Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Phe Thr Arg Leu 
            100                 105                 110         


Glu Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Thr Leu Ala Lys 
        115                 120                 125             


Asn Pro Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Arg 
    130                 135                 140                 


Asp Leu Asp Gln Leu Val Ser Asp Arg Val Ala Val Leu His Pro Glu 
145                 150                 155                 160 


Gly His Leu Ile Thr Pro Glu Trp Leu Trp Gln Lys Tyr Gly Leu Lys 
                165                 170                 175     


Pro Glu Gln Trp Val Asp Phe Arg Ala Leu Val Gly Asp Pro Ser Asp 
            180                 185                 190         


Asn Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Leu Lys Leu 
        195                 200                 205             


Leu Lys Glu Trp Gly Ser Leu Glu Asn Leu Leu Lys Asn Leu Asp Arg 
    210                 215                 220                 


Val Lys Pro Glu Asn Val Arg Glu Lys Ile Lys Ala His Leu Glu Asp 
225                 230                 235                 240 


Leu Arg Leu Ser Leu Glu Leu Ser Arg Val Arg Thr Asp Leu Pro Leu 
                245                 250                 255     


Glu Val Asp Leu Ala Gln Gly Arg Glu Pro Asp Arg Glu Gly Leu Arg 
            260                 265                 270         


Ala Phe Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly 
        275                 280                 285             


Leu Leu Glu Ala Pro Ala Pro Leu Glu Glu Ala Pro Trp Pro Pro Pro 
    290                 295                 300                 


Glu Gly Ala Phe Val Gly Phe Val Leu Ser Arg Pro Glu Pro Met Trp 
305                 310                 315                 320 


Ala Glu Leu Lys Ala Leu Ala Ala Cys Arg Asp Gly Arg Val His Arg 
                325                 330                 335     


Ala Ala Asp Pro Leu Ala Gly Leu Lys Asp Leu Lys Glu Val Arg Gly 
            340                 345                 350         


Leu Leu Ala Lys Asp Leu Ala Val Leu Ala Ser Arg Glu Gly Leu Asp 
        355                 360                 365             


Leu Val Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro 
    370                 375                 380                 


Ser Asn Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp 
385                 390                 395                 400 


Thr Glu Asp Ala Ala His Arg Ala Leu Leu Ser Glu Arg Leu His Arg 
                405                 410                 415     


Asn Leu Leu Lys Arg Leu Gln Gly Glu Glu Lys Leu Leu Trp Leu Tyr 
            420                 425                 430         


His Glu Val Glu Lys Pro Leu Ser Arg Val Leu Ala His Met Glu Ala 
        435                 440                 445             


Thr Gly Val Arg Leu Asp Val Ala Tyr Leu Gln Ala Leu Ser Leu Glu 
    450                 455                 460                 


Leu Ala Glu Glu Ile Arg Arg Leu Glu Glu Glu Val Phe Arg Leu Ala 
465                 470                 475                 480 


Gly His Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu 
                485                 490                 495     


Phe Asp Glu Leu Arg Leu Pro Ala Leu Gly Lys Thr Gln Lys Thr Gly 
            500                 505                 510         


Lys Arg Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His 
        515                 520                 525             


Pro Ile Val Glu Lys Ile Leu Gln His Arg Glu Leu Thr Lys Leu Lys 
    530                 535                 540                 


Asn Thr Tyr Val Asp Pro Leu Pro Ser Leu Val His Pro Asn Thr Gly 
545                 550                 555                 560 


Arg Leu His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu 
                565                 570                 575     


Ser Ser Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu 
            580                 585                 590         


Gly Gln Arg Ile Arg Arg Ala Phe Val Ala Glu Ala Gly Trp Ala Leu 
        595                 600                 605             


Val Ala Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu 
    610                 615                 620                 


Ser Gly Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Lys Asp Ile 
625                 630                 635                 640 


His Thr Gln Thr Ala Ser Trp Met Phe Gly Val Pro Pro Glu Ala Val 
                645                 650                 655     


Asp Pro Leu Met Arg Arg Ala Ala Lys Thr Val Asn Phe Gly Val Leu 
            660                 665                 670         


Tyr Gly Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr 
        675                 680                 685             


Glu Glu Ala Val Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys 
    690                 695                 700                 


Val Arg Ala Trp Ile Glu Lys Thr Leu Glu Glu Gly Arg Lys Arg Gly 
705                 710                 715                 720 


Tyr Val Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Asn 
                725                 730                 735     


Ala Arg Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn 
            740                 745                 750         


Met Pro Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val 
        755                 760                 765             


Lys Leu Phe Pro Arg Leu Arg Glu Met Gly Ala Arg Met Leu Leu Gln 
    770                 775                 780                 


Val His Asp Glu Leu Leu Leu Glu Ala Pro Gln Ala Gly Ala Glu Glu 
785                 790                 795                 800 


Val Ala Ala Leu Ala Lys Glu Ala Met Glu Lys Ala Tyr Pro Leu Ala 
                805                 810                 815     


Val Pro Leu Glu Val Glu Val Gly Met Gly Glu Asp Trp Leu Ser Ala 
            820                 825                 830         


Lys Gly 
        


<210>  4
<211>  833
<212>  PRT
<213>  Thermus filiformis

<400>  4

Met Thr Pro Leu Phe Asp Leu Glu Glu Pro Pro Lys Arg Val Leu Leu 
1               5                   10                  15      


Val Asp Gly His His Leu Ala Tyr Arg Thr Phe Tyr Ala Leu Ser Leu 
            20                  25                  30          


Thr Thr Ser Arg Gly Glu Pro Val Gln Met Val Tyr Gly Phe Ala Arg 
        35                  40                  45              


Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Gln Ala Val Val Val Val 
    50                  55                  60                  


Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Glu Ala Tyr 
65                  70                  75                  80  


Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu Ala 
                85                  90                  95      


Leu Val Lys Arg Leu Val Asp Leu Leu Gly Leu Val Arg Leu Glu Ala 
            100                 105                 110         


Pro Gly Tyr Glu Ala Asp Asp Val Leu Gly Thr Leu Ala Lys Lys Ala 
        115                 120                 125             


Glu Arg Glu Gly Met Glu Val Arg Ile Leu Thr Gly Asp Arg Asp Phe 
    130                 135                 140                 


Phe Gln Leu Leu Ser Glu Lys Val Ser Val Leu Leu Pro Asp Gly Thr 
145                 150                 155                 160 


Leu Val Thr Pro Lys Asp Val Gln Glu Lys Tyr Gly Val Pro Pro Glu 
                165                 170                 175     


Arg Trp Val Asp Phe Arg Ala Leu Thr Gly Asp Arg Ser Asp Asn Ile 
            180                 185                 190         


Pro Gly Val Ala Gly Ile Gly Glu Lys Thr Ala Leu Arg Leu Leu Ala 
        195                 200                 205             


Glu Trp Gly Ser Val Glu Asn Leu Leu Lys Asn Leu Asp Arg Val Lys 
    210                 215                 220                 


Pro Asp Ser Leu Arg Arg Lys Ile Glu Ala His Leu Glu Asp Leu His 
225                 230                 235                 240 


Leu Ser Leu Asp Leu Ala Arg Ile Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     


Asp Phe Lys Ala Leu Arg Arg Arg Thr Pro Asp Leu Glu Gly Leu Arg 
            260                 265                 270         


Ala Phe Leu Glu Glu Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly 
        275                 280                 285             


Leu Leu Gly Gly Glu Lys Pro Arg Glu Glu Ala Pro Trp Pro Pro Pro 
    290                 295                 300                 


Glu Gly Ala Phe Val Gly Phe Leu Leu Ser Arg Lys Glu Pro Met Trp 
305                 310                 315                 320 


Ala Glu Leu Leu Ala Leu Ala Ala Ala Ser Glu Gly Arg Val His Arg 
                325                 330                 335     


Ala Thr Ser Pro Val Glu Ala Leu Ala Asp Leu Lys Glu Ala Arg Gly 
            340                 345                 350         


Phe Leu Ala Lys Asp Leu Ala Val Leu Ala Leu Arg Glu Gly Val Ala 
        355                 360                 365             


Leu Asp Pro Thr Asp Asp Pro Leu Leu Val Ala Tyr Leu Leu Asp Pro 
    370                 375                 380                 


Ala Asn Thr His Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Phe 
385                 390                 395                 400 


Thr Glu Asp Ala Ala Glu Arg Ala Leu Leu Ser Glu Arg Leu Phe Gln 
                405                 410                 415     


Asn Leu Phe Pro Arg Leu Ser Glu Lys Leu Leu Trp Leu Tyr Gln Glu 
            420                 425                 430         


Val Glu Arg Pro Leu Ser Arg Val Leu Ala His Met Glu Ala Arg Gly 
        435                 440                 445             


Val Arg Leu Asp Val Pro Leu Leu Glu Ala Leu Ser Phe Glu Leu Glu 
    450                 455                 460                 


Lys Glu Met Glu Arg Leu Glu Gly Glu Val Phe Arg Leu Ala Gly His 
465                 470                 475                 480 


Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp 
                485                 490                 495     


Glu Leu Gly Leu Thr Pro Val Gly Arg Thr Glu Lys Thr Gly Lys Arg 
            500                 505                 510         


Ser Thr Ala Gln Gly Ala Leu Glu Ala Leu Arg Gly Ala His Pro Ile 
        515                 520                 525             


Val Glu Leu Ile Leu Gln Tyr Arg Glu Leu Ser Lys Leu Lys Ser Thr 
    530                 535                 540                 


Tyr Leu Asp Pro Leu Pro Arg Leu Val His Pro Arg Thr Gly Arg Leu 
545                 550                 555                 560 


His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser 
                565                 570                 575     


Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln 
            580                 585                 590         


Arg Ile Arg Lys Ala Phe Val Ala Glu Glu Gly Trp Leu Leu Leu Ala 
        595                 600                 605             


Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly 
    610                 615                 620                 


Asp Glu Asn Leu Lys Arg Val Phe Arg Glu Gly Lys Asp Ile His Thr 
625                 630                 635                 640 


Glu Thr Ala Ala Trp Met Phe Gly Leu Asp Pro Ala Leu Val Asp Pro 
                645                 650                 655     


Lys Met Arg Arg Ala Ala Lys Thr Val Asn Phe Gly Val Leu Tyr Gly 
            660                 665                 670         


Met Ser Ala His Arg Leu Ser Gln Glu Leu Gly Ile Asp Tyr Lys Glu 
        675                 680                 685             


Ala Glu Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys Val Arg 
    690                 695                 700                 


Ala Trp Ile Glu Arg Thr Leu Glu Glu Gly Arg Thr Arg Gly Tyr Val 
705                 710                 715                 720 


Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Ala Ser Arg 
                725                 730                 735     


Val Arg Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn Met Pro 
            740                 745                 750         


Val Gln Gly Thr Ala Ala Asp Leu Met Lys Ile Ala Met Val Lys Leu 
        755                 760                 765             


Phe Pro Arg Leu Lys Pro Leu Gly Ala His Leu Leu Leu Gln Val His 
    770                 775                 780                 


Asp Glu Leu Val Leu Glu Val Pro Glu Asp Arg Ala Glu Glu Ala Lys 
785                 790                 795                 800 


Ala Leu Val Lys Glu Val Met Glu Asn Ala Tyr Pro Leu Asp Val Pro 
                805                 810                 815     


Leu Glu Val Glu Val Gly Val Gly Arg Asp Trp Leu Glu Ala Lys Gln 
            820                 825                 830         


Asp 
    


<210>  5
<211>  838
<212>  PRT
<213>  Thermodesulfovibrio yellowstonii DSM 11347

<400>  5

Met His Glu Ile Tyr Leu Val Asp Gly Ser Cys Phe Ile Tyr Arg Ala 
1               5                   10                  15      


Tyr His Ala Ile Lys Gly Leu Ser Thr Ser Arg Gly Ile Pro Thr Asn 
            20                  25                  30          


Ala Ile Tyr Gly Phe Thr Arg Met Leu Leu Lys Leu Leu Arg Glu Lys 
        35                  40                  45              


Asn Val Lys Tyr Ile Leu Cys Ala Phe Asp Ser Pro His Pro Thr Lys 
    50                  55                  60                  


Arg His Lys Ile Tyr Glu Glu Tyr Lys Ile Thr Arg Pro Glu Thr Pro 
65                  70                  75                  80  


Lys Asp Leu Pro Val Gln Ile Asp Tyr Ile Lys Gln Ile Ile Asp Ala 
                85                  90                  95      


Leu Gly Ile Thr Arg Ile Glu Val Pro Gly Tyr Glu Ala Asp Asp Ile 
            100                 105                 110         


Ile Ala Thr Ala Val Gly Val Ile Asn Gln Phe Ala Pro Leu Asn Phe 
        115                 120                 125             


Ile Ile Ile Ser Ile Asp Lys Asp Met Leu Gln Leu Val Ser Asp Asn 
    130                 135                 140                 


Val Lys Ile Tyr Asp Pro Ile Asn Glu Leu Ile Ile Asp Arg Glu Tyr 
145                 150                 155                 160 


Val Ile Lys Lys Tyr Gly Val Pro Pro Glu Lys Leu Asn Asp Phe Met 
                165                 170                 175     


Ala Leu Val Gly Asp Ala Ile Asp Asn Ile Pro Gly Val Lys Gly Ile 
            180                 185                 190         


Gly Glu Lys Thr Ala Ala Asn Leu Ile Lys Arg Tyr Gly Ser Ile Glu 
        195                 200                 205             


Asn Ile Leu Lys Asn Leu Asp Ile Ile Lys Pro Leu Lys Val Ser Asp 
    210                 215                 220                 


Ile Ile Lys Lys Asn Ile Lys Ser Leu Gln Leu Ser Lys Glu Leu Val 
225                 230                 235                 240 


Ile Leu Arg Lys Asp Thr Pro Ile Glu Ile Lys Leu Asp Asp Leu Lys 
                245                 250                 255     


Ile Lys Gln Gln Asp Arg Glu Lys Leu Val Gln Ile Phe Arg Glu Leu 
            260                 265                 270         


Glu Phe Asn Thr Leu Leu Lys Gln Ile Ile Lys Asp Phe Pro Asn His 
        275                 280                 285             


Ser Ser Cys Ser Val Leu Gln Leu Asn Leu Ala Ser Glu Asn Arg Arg 
    290                 295                 300                 


Asn Thr Ile Glu Leu Ile Glu Lys Ile Lys Glu Tyr Gly Lys Phe Ser 
305                 310                 315                 320 


Val Thr Phe Asn Lys Asp Ser Ile Ile Ala Gly Val Asn Gly Thr Leu 
                325                 330                 335     


Tyr Glu Ile Ala Phe Asn Asp Thr Arg Val Asn Glu Ile Leu Ser Ser 
            340                 345                 350         


Glu Ile Leu Lys Ile Ile Tyr Asn Ala Lys Glu Ala Leu Lys Lys Leu 
        355                 360                 365             


Lys Asn Ser Gly Leu Lys Leu Ser Pro Pro Tyr Phe Asp Leu Met Ile 
    370                 375                 380                 


Val Ala Tyr Leu Ile Asn Pro Asn Arg Gly Lys Tyr Asn Ile Asp Glu 
385                 390                 395                 400 


Leu Ile Leu Glu Tyr Thr Gly Lys Phe Tyr Glu Asn Ala Glu Asn Ile 
                405                 410                 415     


Asn Phe Tyr Met Phe Glu Leu Tyr Glu Lys Leu Asn Lys Glu Leu Lys 
            420                 425                 430         


Glu Lys Glu Leu Glu Asn Leu Tyr Phe Asp Ile Glu Met Pro Leu Ile 
        435                 440                 445             


Glu Val Leu Phe Asp Met Glu Glu Thr Gly Ile Lys Val Asn Ile Glu 
    450                 455                 460                 


Lys Leu Glu Thr Leu Thr Lys His Ile Ser Met Glu Leu Asp Lys Ile 
465                 470                 475                 480 


Lys Glu Lys Ile Tyr Thr Ile Ala Gly Thr Glu Phe Asn Ile Asn Ser 
                485                 490                 495     


Pro Lys Gln Leu Ala Glu Val Leu Tyr Asp Arg Leu Gly Leu Lys Thr 
            500                 505                 510         


Arg Lys Arg Gly Lys Lys Ala Arg Ser Thr Glu Met Glu Val Leu Glu 
        515                 520                 525             


Glu Leu Ala Ile Gln His Glu Leu Pro His Glu Val Ile Asn Tyr Arg 
    530                 535                 540                 


Thr Leu Asn Lys Leu Leu Thr Gly Tyr Leu Ile Pro Leu Arg Asp Tyr 
545                 550                 555                 560 


Ile Asn Pro Glu Thr Lys Arg Ile His Thr Lys Trp Ser Gln Thr Val 
                565                 570                 575     


Ala Gly Thr Gly Arg Ile Val Ser Ser Glu Pro Asn Leu Gln Asn Ile 
            580                 585                 590         


Pro Val Lys Gly Glu Trp Ala Glu Phe Leu Arg Glu Val Phe Ile Pro 
        595                 600                 605             


Glu Asn Gly Tyr Met Phe Leu Ser Ala Asp Tyr Ser Gln Ile Glu Leu 
    610                 615                 620                 


Arg Leu Leu Ala His Met Ser Glu Asp Pro Ala Leu Ile Lys Ala Phe 
625                 630                 635                 640 


Leu Asp Gly Lys Asp Ile His Thr Ala Thr Ala Ser Glu Ile Phe Ser 
                645                 650                 655     


Ile Pro Glu Asn Ala Val Thr Asp Glu His Arg Arg Ile Ala Lys Thr 
            660                 665                 670         


Val Asn Phe Gly Ile Ser Tyr Gly Ile Ser Pro Phe Gly Leu Ser Glu 
        675                 680                 685             


Ser Ile Lys Ile Pro Tyr Glu Lys Ala Glu Glu Leu Ile Glu Leu Tyr 
    690                 695                 700                 


Phe Leu Arg Tyr Pro Met Val Arg Lys Phe Ile Glu Glu Thr Ile Ser 
705                 710                 715                 720 


Phe Ala Gln Lys Asn Gly Tyr Val Arg Thr Leu Phe Gly Arg Ile Arg 
                725                 730                 735     


Pro Leu Pro Glu Ile Asn Ser Pro Asn Gln Phe Leu Arg Met Gln Ser 
            740                 745                 750         


Glu Arg Met Ala Val Asn Ala Arg Val Gln Gly Thr Ala Ala Asp Ile 
        755                 760                 765             


Ile Lys Ile Ala Met Ile Arg Ile Tyr Asn Arg Leu Lys Lys Glu Lys 
    770                 775                 780                 


Leu Asn Ala Lys Ile Ile Leu Gln Ile His Asp Glu Ile Val Leu Glu 
785                 790                 795                 800 


Val Glu Gln Lys Val Ile Glu Lys Val Ser Glu Ile Val Gln Asn Glu 
                805                 810                 815     


Met Lys Asp Phe Ser Leu Ser Val Pro Leu Glu Val Asn Val Phe Ser 
            820                 825                 830         


Gly Asn Ser Leu Asn Leu 
        835             


<210>  6
<211>  856
<212>  PRT
<213>  Dictyoglomus thermophilum

<400>  6

Met Glu Gln Lys Ser Leu Trp Asp Leu Phe Gln Glu Asn Thr Glu Lys 
1               5                   10                  15      


Glu Ser Lys Arg Lys Ile Leu Ile Ile Asp Gly Ser Ser Leu Ile Tyr 
            20                  25                  30          


Arg Val Tyr Tyr Ala Leu Pro Pro Leu Lys Thr Lys Asn Gly Glu Leu 
        35                  40                  45              


Thr Asn Ala Leu Tyr Gly Phe Ile Arg Ile Leu Leu Lys Ala Val Glu 
    50                  55                  60                  


Asp Phe Asn Pro Asp Leu Val Gly Val Ala Phe Asp Arg Pro Glu Pro 
65                  70                  75                  80  


Thr Phe Arg His Val Ile Tyr Lys Glu Tyr Lys Ala Lys Arg Pro Pro 
                85                  90                  95      


Met Lys Asp Asp Leu Lys Ala Gln Ile Pro Trp Ile Arg Glu Phe Leu 
            100                 105                 110         


Arg Leu Asn Asp Ile Pro Leu Leu Glu Glu Pro Gly Tyr Glu Ala Asp 
        115                 120                 125             


Asp Ile Ile Ala Thr Ile Val Asn Lys Tyr Lys Asp Asp Leu Lys Tyr 
    130                 135                 140                 


Ile Leu Ser Gly Asp Leu Asp Leu Leu Gln Leu Val Ser Asp Lys Thr 
145                 150                 155                 160 


Phe Leu Ile His Pro Gln Lys Gly Ile Thr Glu Phe Thr Ile Tyr Asp 
                165                 170                 175     


Pro Lys Ala Val Lys Asp Arg Phe Gly Val Glu Pro Tyr Lys Ile Pro 
            180                 185                 190         


Leu Tyr Lys Val Leu Val Gly Asp Glu Ser Asp Asn Ile Pro Gly Val 
        195                 200                 205             


Asn Gly Ile Gly Pro Lys Lys Ala Ser Lys Ile Leu Glu Lys Ile Ser 
    210                 215                 220                 


Ser Val Asp Glu Phe Lys Ser Lys Ile Lys Val Leu Asp Ser Asp Leu 
225                 230                 235                 240 


Arg Glu Leu Ile Glu Lys Asn Trp Asn Ile Ile Glu Arg Asn Leu Glu 
                245                 250                 255     


Leu Val Thr Leu Lys Asn Ile Asp Lys Asp Leu Ile Leu Lys Pro Phe 
            260                 265                 270         


Glu Ile Lys Arg Asp Glu Lys Val Ile Asp Phe Leu Lys Arg Tyr Glu 
        275                 280                 285             


Leu Lys Ser Ile Leu Gln Lys Leu Phe Pro Asp Leu Gln Glu Glu Glu 
    290                 295                 300                 


Asn Ile Glu Ile Lys Asp Val Glu Glu Ile Asn Phe Asn Glu Val Glu 
305                 310                 315                 320 


Lys Glu Gly Tyr Phe Ala Phe Lys Cys Leu Gly Asp Arg Ala Phe Glu 
                325                 330                 335     


Gly Ile Ser Leu Ser Phe Lys Glu Gly Glu Gly Tyr Phe Ile Ser Pro 
            340                 345                 350         


Phe Asp Phe Asn Asn Glu Ile Arg Lys Lys Ile Glu Asn Ile Ile Ser 
        355                 360                 365             


Ser Glu Asn Val Lys Lys Ile Gly Ser Tyr Ile Gln Arg Asp Leu His 
    370                 375                 380                 


Phe Leu Asn Cys Lys Ile Lys Gly Asp Val Phe Asp Val Ser Leu Ala 
385                 390                 395                 400 


Ser Tyr Leu Leu Asn Pro Glu Arg Gln Asn His Ser Leu Asp Ile Leu 
                405                 410                 415     


Ile Gly Glu Tyr Leu Asn Lys Thr Ser Phe Ile Pro Gln Lys Tyr Ala 
            420                 425                 430         


Gly Tyr Leu Phe Pro Leu Lys Ser Ile Leu Glu Glu Arg Ile Lys Asn 
        435                 440                 445             


Glu Gly Leu Glu Phe Val Leu Tyr Asn Ile Glu Ile Pro Leu Ile Pro 
    450                 455                 460                 


Val Leu Tyr Ser Met Glu Lys Trp Gly Ile Lys Val Asp Lys Glu Tyr 
465                 470                 475                 480 


Leu Lys Gln Leu Ser Asp Glu Phe Cys Glu Arg Ile Lys Lys Leu Glu 
                485                 490                 495     


Glu Glu Ile Tyr Glu Leu Ala Gly Thr Arg Phe Asn Leu Asn Ser Pro 
            500                 505                 510         


Lys Gln Leu Ser Glu Val Leu Phe Glu Arg Leu Lys Leu Pro Ser Gly 
        515                 520                 525             


Lys Lys Gly Lys Thr Gly Tyr Ser Thr Ser Ser Ser Val Leu Gln Asn 
    530                 535                 540                 


Leu Ile Asn Ala His Pro Ile Val Arg Lys Ile Leu Gln Tyr Arg Glu 
545                 550                 555                 560 


Leu Tyr Lys Leu Lys Ser Thr Tyr Val Asp Ala Ile Pro Asn Leu Val 
                565                 570                 575     


Asn Pro Gln Thr Gly Arg Val His Thr Lys Phe Asn Pro Thr Gly Thr 
            580                 585                 590         


Ala Thr Gly Arg Ile Ser Ser Ser Glu Pro Asn Leu Gln Asn Ile Pro 
        595                 600                 605             


Ile Lys Ser Glu Glu Gly Arg Lys Ile Arg Arg Ala Phe Val Ser Glu 
    610                 615                 620                 


Asp Gly Tyr Phe Leu Val Ser Leu Asp Tyr Ser Gln Ile Glu Leu Arg 
625                 630                 635                 640 


Ile Met Ala His Leu Ser Gln Glu Pro Lys Leu Ile Ser Ala Phe Gln 
                645                 650                 655     


Lys Gly Glu Asp Ile His Arg Arg Thr Ala Ser Glu Ile Phe Gly Val 
            660                 665                 670         


Pro Glu Glu Glu Val Asp Asp Leu Leu Arg Ser Arg Ala Lys Ala Val 
        675                 680                 685             


Asn Phe Gly Ile Ile Tyr Gly Ile Ser Ser Phe Gly Leu Ser Glu Thr 
    690                 695                 700                 


Val Ser Ile Thr Pro Glu Glu Ala Glu Lys Phe Ile Asp Ser Tyr Phe 
705                 710                 715                 720 


Lys His Tyr Pro Arg Val Lys Leu Phe Ile Asp Lys Thr Ile His Glu 
                725                 730                 735     


Ala Arg Glu Lys Leu Tyr Val Lys Thr Leu Phe Gly Arg Lys Arg Tyr 
            740                 745                 750         


Ile Pro Glu Ile Lys Ser Ile Asn Lys Gln Val Arg Asn Ala Tyr Glu 
        755                 760                 765             


Arg Ile Ala Ile Asn Ala Pro Ile Gln Gly Thr Ala Ala Asp Ile Ile 
    770                 775                 780                 


Lys Leu Ala Met Ile Glu Ile Tyr Lys Glu Ile Glu Asn Lys Asn Leu 
785                 790                 795                 800 


Lys Ser Arg Ile Leu Leu Gln Ile His Asp Glu Leu Ile Leu Glu Val 
                805                 810                 815     


Pro Glu Glu Glu Met Glu Phe Thr Pro Leu Met Ala Lys Glu Lys Met 
            820                 825                 830         


Glu Lys Val Val Glu Leu Ser Val Pro Leu Val Val Glu Ile Ser Val 
        835                 840                 845             


Gly Lys Asn Leu Ala Glu Leu Lys 
    850                 855     


<210>  7
<211>  930
<212>  PRT
<213>  Natranaerobius thermophilus

<400>  7

Met Asn Ser Asn Asp Tyr Gln Ala Asn Asp Lys Phe Val Val Ile Asp 
1               5                   10                  15      


Gly Asn Ser Leu Leu Asn Arg Ala Phe Tyr Ala Leu Pro Leu Leu Gln 
            20                  25                  30          


Thr Lys Gln Gly Phe Phe Thr Asn Ala Ile Tyr Gly Phe Thr Thr Met 
        35                  40                  45              


Leu Leu Lys Leu Val Gln Asp Glu Ser Pro Asn Tyr Leu Ala Val Val 
    50                  55                  60                  


Phe Asp Thr Lys Ala Lys Thr Phe Arg His His Lys Phe Pro Glu Tyr 
65                  70                  75                  80  


Lys Gly His Arg Asp Lys Ala Pro Asp Glu Met Arg Pro Gln Met Pro 
                85                  90                  95      


Met Leu Lys Glu Leu Leu Glu Ala Met Asn Ile Asn Tyr Phe Glu Lys 
            100                 105                 110         


Asp Gly Tyr Glu Ala Asp Asp Leu Ile Gly Ala Phe Thr Lys Ile Ala 
        115                 120                 125             


Lys Gln Glu Asp Lys Glu Thr Met Val Val Thr Gly Asp Lys Asp Leu 
    130                 135                 140                 


Leu Gln Leu Leu Asp Asp Lys Thr Thr Ile Leu Leu Thr Lys Lys Gly 
145                 150                 155                 160 


Ile Thr Gln Met Glu Ser Tyr Asp Gly Glu Lys Val Lys Glu Glu Phe 
                165                 170                 175     


Gly Val Asn Val Asp Lys Leu Ile Asp Leu Lys Ala Leu Thr Gly Asp 
            180                 185                 190         


Lys Ser Asp Asn Val Pro Gly Val Pro Gly Val Gly Lys Lys Thr Ala 
        195                 200                 205             


Leu Lys Leu Leu Asn Asn Tyr Gly Asp Leu Glu Lys Leu Tyr Lys Ser 
    210                 215                 220                 


Leu Asp Gly Val Gly Gly Lys Leu Gln Ser Lys Leu Ala Asp Asn Lys 
225                 230                 235                 240 


Asp Lys Ala Phe Leu Ser Lys Glu Leu Val Thr Ile Asp Cys Glu Glu 
                245                 250                 255     


Ser Leu Ile Glu Asn Leu Asp Trp Asn Gln Leu Ser Lys Phe Glu Ile 
            260                 265                 270         


Ala Ser Pro Lys Ala Arg Glu Leu Leu Gln Glu Trp Glu Met Asn Ser 
        275                 280                 285             


Ile Leu Glu Arg Leu Pro Ala Ser Asp Glu Glu Gln Lys Lys Asp Gln 
    290                 295                 300                 


Ser Pro Val Asn Glu Gly Lys Thr Ser Ser Phe Asn Trp Asp Asn Phe 
305                 310                 315                 320 


Tyr Tyr Ile Ser Glu Phe Pro His Glu Asn Ser Asp Asn Leu Glu Ser 
                325                 330                 335     


Glu Leu Glu Lys Phe Ile Gln Asp Gly Asn His Lys Met Ala Leu Tyr 
            340                 345                 350         


Arg His Leu Pro Lys Lys Leu Ser Thr Ala Lys Gln Lys Asp Ser Tyr 
        355                 360                 365             


Pro Glu Pro Glu Gly Gly Leu Val Val Ser Ile Asn Asp Leu Ile Phe 
    370                 375                 380                 


Tyr Val Pro Glu Lys Leu Leu Ser Gln Val Leu Ala Glu Thr Ile Ala 
385                 390                 395                 400 


Pro Lys Leu Ile Lys Gly Asn Asp Lys Gly Thr Glu Thr Glu Asp Ala 
                405                 410                 415     


Pro Lys Leu Lys Ile Ala Ser Tyr Asn Ile Lys Arg Ile Trp His Leu 
            420                 425                 430         


Phe Lys Asn Asn Thr Glu Leu Asp Leu Tyr Asp Leu Asp Thr Asn Lys 
        435                 440                 445             


Phe Leu Phe Tyr Asp Thr Glu Leu Met Ala Tyr Leu Leu Glu Pro Thr 
    450                 455                 460                 


Glu Ala Pro His Ser Ile Glu Asp Met Met Asn Arg Tyr Tyr Gly Gln 
465                 470                 475                 480 


Phe Asp Leu Thr Pro Tyr Gly Gln Asp Trp Gln Ala Val Cys Glu Arg 
                485                 490                 495     


Gly Ala Ile Leu Leu Asp Leu Ile Ser Pro Leu Glu Asp Ile Leu Gln 
            500                 505                 510         


Glu Arg Asn Gln Trp Gln Leu Tyr Lys Asn Ile Glu Leu Pro Leu Ala 
        515                 520                 525             


Phe Ile Leu Ala Arg Met Glu Phe Arg Gly Ile Lys Val Asp Ala Arg 
    530                 535                 540                 


Val Leu Thr Glu Met Glu Ala Asn Ile Asp His Arg Leu Ser Glu Ile 
545                 550                 555                 560 


Ser Thr Lys Ile Phe Glu Ile Ala Gly Glu Glu Phe Asn Leu Asn Ser 
                565                 570                 575     


Pro Lys Gln Leu Gly Tyr Ile Leu Phe Glu Lys Leu Gln Leu Pro Val 
            580                 585                 590         


Val Lys Lys Thr Lys Thr Gly Tyr Ser Thr Asp Ala Lys Thr Leu Glu 
        595                 600                 605             


Thr Leu Ser His Asp Tyr Glu Ile Cys Lys Leu Leu Leu Asp Tyr Arg 
    610                 615                 620                 


Gln Leu His Lys Leu Lys Thr Thr Tyr Leu Val Gly Leu Lys Asp Leu 
625                 630                 635                 640 


Ile Ser Lys Thr Thr Gly Lys Ile His Thr Thr Tyr Asn Gln Thr Ile 
                645                 650                 655     


Thr Ala Thr Gly Arg Leu Ser Ser Thr Asp Pro Asn Leu Gln Asn Ile 
            660                 665                 670         


Pro Ile Lys Leu Glu Glu Gly Arg Lys Ile Arg Lys Gly Phe Val Ile 
        675                 680                 685             


Gln Asn Ser Asp Gln Leu Phe Leu Ala Ala Asp Tyr Ser Gln Ile Glu 
    690                 695                 700                 


Leu Arg Ile Leu Ala His Val Ser Glu Asp Thr Asn Leu Ile Gln Ala 
705                 710                 715                 720 


Phe Gln Glu Gln Gln Asp Ile His Thr Gln Thr Ala Ala Gln Val Phe 
                725                 730                 735     


Glu Val Glu Ser Thr Gln Val Thr Arg Glu Met Arg Ser His Ala Lys 
            740                 745                 750         


Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Asp Tyr Gly Leu Ser 
        755                 760                 765             


Arg Gln Leu Gly Ile Ser Arg Lys Gln Ala Lys Thr Tyr Ile Asp Asn 
    770                 775                 780                 


Tyr Leu Thr Arg Phe Ser Gly Val Lys Glu Tyr Met Asp Gln Ile Val 
785                 790                 795                 800 


Asn Gln Ala Lys Met Asn Gly Tyr Val Glu Thr Leu Tyr Asn Arg Arg 
                805                 810                 815     


Arg Asn Leu Pro Asp Ile Ser His Arg Asn Phe Asn Ile Arg Ser Ala 
            820                 825                 830         


Ala Glu Arg Thr Ala Ile Asn Thr Pro Ile Gln Gly Thr Ala Ala Asp 
        835                 840                 845             


Ile Ile Lys Asp Ala Met Val Lys Val Glu Lys Glu Leu Glu Lys Gln 
    850                 855                 860                 


Asp Leu Leu Asp Lys Ala Ala Leu Leu Leu Gln Val His Asp Glu Leu 
865                 870                 875                 880 


Ile Leu Glu Ile Asn Lys Glu Val Leu Ser Asp Val Ala Thr Lys Val 
                885                 890                 895     


Lys Glu Ile Met Glu Asn Ile Ile Glu Leu Lys Val Pro Leu Thr Val 
            900                 905                 910         


Asp Leu Lys Thr Gly Pro Asn Trp Tyr Asp Leu Asn Pro Tyr Gln Ser 
        915                 920                 925             


Gly Glu 
    930 


<210>  8
<211>  928
<212>  PRT
<213>  Escherichia coli

<400>  8

Met Val Gln Ile Pro Gln Asn Pro Leu Ile Leu Val Asp Gly Ser Ser 
1               5                   10                  15      


Tyr Leu Tyr Arg Ala Tyr His Ala Phe Pro Pro Leu Thr Asn Ser Ala 
            20                  25                  30          


Gly Glu Pro Thr Gly Ala Met Tyr Gly Val Leu Asn Met Leu Arg Ser 
        35                  40                  45              


Leu Ile Met Gln Tyr Lys Pro Thr His Ala Ala Val Val Phe Asp Ala 
    50                  55                  60                  


Lys Gly Lys Thr Phe Arg Asp Glu Leu Phe Glu His Tyr Lys Ser His 
65                  70                  75                  80  


Arg Pro Pro Met Pro Asp Asp Leu Arg Ala Gln Ile Glu Pro Leu His 
                85                  90                  95      


Ala Met Val Lys Ala Met Gly Leu Pro Leu Leu Ala Val Ser Gly Val 
            100                 105                 110         


Glu Ala Asp Asp Val Ile Gly Thr Leu Ala Arg Glu Ala Glu Lys Ala 
        115                 120                 125             


Gly Arg Pro Val Leu Ile Ser Thr Gly Asp Lys Asp Met Ala Gln Leu 
    130                 135                 140                 


Val Thr Pro Asn Ile Thr Leu Ile Asn Thr Met Thr Asn Thr Ile Leu 
145                 150                 155                 160 


Gly Pro Glu Glu Val Val Asn Lys Tyr Gly Val Pro Pro Glu Leu Ile 
                165                 170                 175     


Ile Asp Phe Leu Ala Leu Met Gly Asp Ser Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Pro Gly Val Gly Glu Lys Thr Ala Gln Ala Leu Leu Gln Gly Leu 
        195                 200                 205             


Gly Gly Leu Asp Thr Leu Tyr Ala Glu Pro Glu Lys Ile Ala Gly Leu 
    210                 215                 220                 


Ser Phe Arg Gly Ala Lys Thr Met Ala Ala Lys Leu Glu Gln Asn Lys 
225                 230                 235                 240 


Glu Val Ala Tyr Leu Ser Tyr Gln Leu Ala Thr Ile Lys Thr Asp Val 
                245                 250                 255     


Glu Leu Glu Leu Thr Cys Glu Gln Leu Glu Val Gln Gln Pro Ala Ala 
            260                 265                 270         


Glu Glu Leu Leu Gly Leu Phe Lys Lys Tyr Glu Phe Lys Arg Trp Thr 
        275                 280                 285             


Ala Asp Val Glu Ala Gly Lys Trp Leu Gln Ala Lys Gly Ala Lys Pro 
    290                 295                 300                 


Ala Ala Lys Pro Gln Glu Thr Ser Val Ala Asp Glu Ala Pro Glu Val 
305                 310                 315                 320 


Thr Ala Thr Val Ile Ser Tyr Asp Asn Tyr Val Thr Ile Leu Asp Glu 
                325                 330                 335     


Glu Thr Leu Lys Ala Trp Ile Ala Lys Leu Glu Lys Ala Pro Val Phe 
            340                 345                 350         


Ala Phe Asp Thr Glu Thr Asp Ser Leu Asp Asn Ile Ser Ala Asn Leu 
        355                 360                 365             


Val Gly Leu Ser Phe Ala Ile Glu Pro Gly Val Ala Ala Tyr Ile Pro 
    370                 375                 380                 


Val Ala His Asp Tyr Leu Asp Ala Pro Asp Gln Ile Ser Arg Glu Arg 
385                 390                 395                 400 


Ala Leu Glu Leu Leu Lys Pro Leu Leu Glu Asp Glu Lys Ala Leu Lys 
                405                 410                 415     


Val Gly Gln Asn Leu Lys Tyr Asp Arg Gly Ile Leu Ala Asn Tyr Gly 
            420                 425                 430         


Ile Glu Leu Arg Gly Ile Ala Phe Asp Thr Met Leu Glu Ser Tyr Ile 
        435                 440                 445             


Leu Asn Ser Val Ala Gly Arg His Asp Met Asp Ser Leu Ala Glu Arg 
    450                 455                 460                 


Trp Leu Lys His Lys Thr Ile Thr Phe Glu Glu Ile Ala Gly Lys Gly 
465                 470                 475                 480 


Lys Asn Gln Leu Thr Phe Asn Gln Ile Ala Leu Glu Glu Ala Gly Arg 
                485                 490                 495     


Tyr Ala Ala Glu Asp Ala Asp Val Thr Leu Gln Leu His Leu Lys Met 
            500                 505                 510         


Trp Pro Asp Leu Gln Lys His Lys Gly Pro Leu Asn Val Phe Glu Asn 
        515                 520                 525             


Ile Glu Met Pro Leu Val Pro Val Leu Ser Arg Ile Glu Arg Asn Gly 
    530                 535                 540                 


Val Lys Ile Asp Pro Lys Val Leu His Asn His Ser Glu Glu Leu Thr 
545                 550                 555                 560 


Leu Arg Leu Ala Glu Leu Glu Lys Lys Ala His Glu Ile Ala Gly Glu 
                565                 570                 575     


Glu Phe Asn Leu Ser Ser Thr Lys Gln Leu Gln Thr Ile Leu Phe Glu 
            580                 585                 590         


Lys Gln Gly Ile Lys Pro Leu Lys Lys Thr Pro Gly Gly Ala Pro Ser 
        595                 600                 605             


Thr Ser Glu Glu Val Leu Glu Glu Leu Ala Leu Asp Tyr Pro Leu Pro 
    610                 615                 620                 


Lys Val Ile Leu Glu Tyr Arg Gly Leu Ala Lys Leu Lys Ser Thr Tyr 
625                 630                 635                 640 


Thr Asp Lys Leu Pro Leu Met Ile Asn Pro Lys Thr Gly Arg Val His 
                645                 650                 655     


Thr Ser Tyr His Gln Ala Val Thr Ala Thr Gly Arg Leu Ser Ser Thr 
            660                 665                 670         


Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Asn Glu Glu Gly Arg Arg 
        675                 680                 685             


Ile Arg Gln Ala Phe Ile Ala Pro Glu Asp Tyr Val Ile Val Ser Ala 
    690                 695                 700                 


Asp Tyr Ser Gln Ile Glu Leu Arg Ile Met Ala His Leu Ser Arg Asp 
705                 710                 715                 720 


Lys Gly Leu Leu Thr Ala Phe Ala Glu Gly Lys Asp Ile His Arg Ala 
                725                 730                 735     


Thr Ala Ala Glu Val Phe Gly Leu Pro Leu Glu Thr Val Thr Ser Glu 
            740                 745                 750         


Gln Arg Arg Ser Ala Lys Ala Ile Asn Phe Gly Leu Ile Tyr Gly Met 
        755                 760                 765             


Ser Ala Phe Gly Leu Ala Arg Gln Leu Asn Ile Pro Arg Lys Glu Ala 
    770                 775                 780                 


Gln Lys Tyr Met Asp Leu Tyr Phe Glu Arg Tyr Pro Gly Val Leu Gln 
785                 790                 795                 800 


Tyr Met Glu Arg Thr Arg Ala Gln Ala Lys Glu Gln Gly Tyr Val Glu 
                805                 810                 815     


Thr Leu Asp Gly Arg Arg Leu Tyr Leu Pro Asp Ile Lys Ser Ser Asn 
            820                 825                 830         


Gly Ala Arg Arg Ala Ala Ala Glu Arg Ala Ala Ile Asn Ala Pro Met 
        835                 840                 845             


Gln Gly Thr Ala Ala Asp Ile Ile Lys Arg Ala Met Ile Ala Val Asp 
    850                 855                 860                 


Ala Trp Leu Gln Ala Glu Gln Pro Arg Val Arg Met Ile Met Gln Val 
865                 870                 875                 880 


His Asp Glu Leu Val Phe Glu Val His Lys Asp Asp Val Asp Ala Val 
                885                 890                 895     


Ala Lys Gln Ile His Gln Leu Met Glu Asn Cys Thr Arg Leu Asp Val 
            900                 905                 910         


Pro Leu Leu Val Glu Val Gly Ser Gly Glu Asn Trp Asp Gln Ala His 
        915                 920                 925             


<210>  9
<211>  892
<212>  PRT
<213>  Thermotoga lettingae TMO

<400>  9

Met Ala Lys Leu Phe Leu Phe Asp Gly Thr Gly Leu Ala Tyr Arg Ala 
1               5                   10                  15      


Tyr Tyr Ala Leu Asp Gln Ser Leu Ser Thr Thr Ser Gly Ile Pro Thr 
            20                  25                  30          


Asn Ala Thr Tyr Gly Val Leu Arg Met Leu Ile Arg Phe Leu Lys Asp 
        35                  40                  45              


Tyr Val Lys Ile Gly Asp Tyr Thr Ala Phe Ala Met Asp Thr Lys Thr 
    50                  55                  60                  


Arg Thr Tyr Arg His Glu Leu Leu Glu Glu Tyr Lys Ala His Arg Pro 
65                  70                  75                  80  


Gln Thr Pro Asp Ala Met Ile Gln Gln Leu Pro Tyr Ile Lys Arg Gly 
                85                  90                  95      


Val Gln Ala Leu Gly Ile Lys Val Leu Glu Tyr Glu Gly Cys Glu Ala 
            100                 105                 110         


Asp Asp Val Ile Ala Thr Leu Ala Arg Met Gly Glu Lys Glu Phe Glu 
        115                 120                 125             


Asp Ile Phe Ile Ile Ser Gly Asp Lys Asp Met Phe Gln Leu Val Asn 
    130                 135                 140                 


Asp Lys Ile Lys Val Trp Arg Pro Ser Lys Gly Ile Thr Asp Leu Glu 
145                 150                 155                 160 


Phe Tyr Asp Lys Lys Lys Ile Ile Glu Lys Tyr Arg Val Glu Pro Ser 
                165                 170                 175     


Lys Ile Val Asp Leu Leu Ala Leu Met Gly Asp Ser Val Asp Asn Val 
            180                 185                 190         


Pro Gly Val Lys Gly Ile Gly Met Lys Thr Ala Ala Glu Leu Ile Glu 
        195                 200                 205             


Lys Phe Gly Asn Leu Asp Glu Ile Tyr Gly Lys Ile Asp Glu Asn Ser 
    210                 215                 220                 


Arg Ile Gly Lys Leu Leu Ser Arg Gly Lys Asp Asp Ala Phe Lys Ser 
225                 230                 235                 240 


Lys Gln Leu Val Thr Leu Met Thr Asp Leu Asp Leu Arg Leu Thr Trp 
                245                 250                 255     


Asp Asp Leu Lys Tyr Ala Gly Tyr Lys Glu Lys Glu Leu Val Glu Phe 
            260                 265                 270         


Leu Arg Glu Met Glu Phe Ser Ser Ile Met Lys Glu Leu Gly Leu Tyr 
        275                 280                 285             


Thr Gln Gln Asp Gln Lys Thr Pro Tyr Ile Ala Val Lys Asp Asn Asn 
    290                 295                 300                 


Ser Leu Asn Glu Leu Phe Glu Lys Ile Lys Lys Ser Gln Tyr Phe Val 
305                 310                 315                 320 


Leu Asp Leu Glu Thr Asp Ser Leu Ser Pro Ile Asp Ala Glu Ile Ile 
                325                 330                 335     


Gly Phe Ser Ile Ser Leu Pro Ser Lys Glu Ser Tyr Tyr Val Pro Leu 
            340                 345                 350         


Ala His Lys Asn Gly Pro Asn Val Asp Lys Lys Ser Ala Leu Asn Asn 
        355                 360                 365             


Leu Lys Ser Ile Leu Glu Asn Gln Ser Ala Lys Ile Ile Gly Gln Asn 
    370                 375                 380                 


Leu Lys Tyr Asp Tyr Ser Val Leu Lys Met His Gly Ile Glu Pro Val 
385                 390                 395                 400 


Arg Pro Ser Phe Asp Thr Met Ile Ala Ala Tyr Leu Leu Asn Pro Asp 
                405                 410                 415     


Glu Lys Arg Phe Asn Leu Asp Glu Leu Ala Met Lys Phe Leu Asn Tyr 
            420                 425                 430         


Lys Met Ile Ser Phe Glu Glu Leu Phe Lys Asp Thr Ser Pro Leu Phe 
        435                 440                 445             


Gly Ala Val Thr Phe Ala Asp Val Ser Val Glu Asp Ala Thr Lys Tyr 
    450                 455                 460                 


Ser Ala Glu Asp Ala Asp Ile Thr Arg Arg Leu Tyr Glu Ile Leu Asn 
465                 470                 475                 480 


Ile Lys Leu His Glu Ala Asp Leu Leu Glu Val Leu Glu Lys Ile Glu 
                485                 490                 495     


Met Pro Leu Ile Pro Val Leu Val His Met Glu Leu Glu Gly Val Tyr 
            500                 505                 510         


Met Asn Ile Asp Tyr Leu Lys Asp Leu Ser Ser Lys Tyr Ala Ala Arg 
        515                 520                 525             


Met Asn Glu Leu Ser Gln Gln Ile Tyr Asn His Ala Gly Glu Ala Phe 
    530                 535                 540                 


Asn Leu Asn Ser Pro Lys Gln Val Ala His Ile Leu Phe Asp Lys Leu 
545                 550                 555                 560 


Lys Ile Gln Pro Thr Lys Lys Thr Ser Thr Gly Glu Pro Ser Thr Arg 
                565                 570                 575     


Ala Asp Val Leu Glu Glu Leu Ser Glu Glu His Pro Ile Val Arg Leu 
            580                 585                 590         


Ile Leu Glu Tyr Arg Lys Tyr Gln Lys Ile Lys Ser Thr Tyr Leu Asp 
        595                 600                 605             


Val Leu Pro Lys Leu Val His Pro Glu Thr Gly Arg Ile His Ser Ser 
    610                 615                 620                 


Phe His Gln Thr Gly Thr Ala Thr Gly Arg Leu Ser Ser Ser Asp Pro 
625                 630                 635                 640 


Asn Leu Gln Asn Leu Pro Ser Lys Gln Glu Glu Ser Arg Glu Ile Arg 
                645                 650                 655     


Lys Ala Val Val Pro Gln Arg Asp Ser Trp Lys Ile Leu Ser Ala Asp 
            660                 665                 670         


Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Asn Asp Gln 
        675                 680                 685             


Asn Leu Ile Glu Ala Phe Lys Lys Asp Glu Asp Ile His Asn Phe Thr 
    690                 695                 700                 


Ser Ser Arg Ile Phe Gln Val Pro Glu Asn Gln Val Thr Pro Gln Met 
705                 710                 715                 720 


Arg Ser Ile Gly Lys Met Val Asn Phe Ser Val Ile Tyr Gly Val Ser 
                725                 730                 735     


Pro Tyr Gly Leu Ser Gln Arg Thr Gly Leu Ser Tyr Asp Gln Ala Gln 
            740                 745                 750         


Lys Phe Ile Gly Glu Tyr Phe Ser Leu Tyr Pro Ser Val Lys Glu Tyr 
        755                 760                 765             


Phe Ala Lys Ile Val Ser Tyr Ala Lys Thr His Gly Tyr Val Arg Thr 
    770                 775                 780                 


Met Phe Gly Arg Arg Arg Glu Val Pro Gln Leu Arg Ser Lys Asn Ala 
785                 790                 795                 800 


Ser Val Arg Gln Glu Gly Glu Arg Ile Ala Ile Asn Thr Pro Ile Gln 
                805                 810                 815     


Gly Thr Ala Ala Asp Ile Met Lys Leu Ala Met Ile Asn Leu Tyr Asp 
            820                 825                 830         


Lys Ile Lys Gln Met Arg Leu Gln Ser Lys Met Ile Leu Gln Val His 
        835                 840                 845             


Asp Glu Leu Val Phe Glu Val Pro Asp Glu Glu Val Glu Ile Val Lys 
    850                 855                 860                 


Asn Leu Val Arg Asp Ser Met Glu Asn Val Val Arg Leu Ser Val Pro 
865                 870                 875                 880 


Leu Lys Val Asp Leu Lys Ile Ser Asp Ser Trp Glu 
                885                 890         


<210>  10
<211>  893
<212>  PRT
<213>  Thermotoga petrophila RKU-1

<400>  10

Met Ala Arg Leu Phe Leu Phe Asp Gly Thr Ala Leu Ala Tyr Arg Ala 
1               5                   10                  15      


Tyr Tyr Ala Leu Asp Arg Ser Leu Ser Thr Ser Ala Gly Ile Pro Thr 
            20                  25                  30          


Asn Ala Thr Tyr Gly Val Ala Arg Met Leu Val Arg Phe Ile Lys Asp 
        35                  40                  45              


His Ile Ile Val Gly Lys Asp Tyr Ala Ala Val Ala Phe Asp Lys Arg 
    50                  55                  60                  


Ala Ala Thr Phe Arg His Lys Leu Leu Glu Thr Tyr Lys Ala Gln Arg 
65                  70                  75                  80  


Pro Lys Thr Pro Asp Leu Leu Ile Gln Gln Leu Pro Tyr Ile Lys Arg 
                85                  90                  95      


Leu Val Glu Ala Leu Gly Met Lys Val Leu Glu Ile Glu Gly Tyr Glu 
            100                 105                 110         


Ala Asp Asp Ile Ile Ala Thr Leu Ala Val Lys Gly Leu Ser Leu Phe 
        115                 120                 125             


Asp Glu Ile Phe Ile Val Thr Gly Asp Lys Asp Met Leu Gln Leu Val 
    130                 135                 140                 


Asn Glu Lys Ile Lys Val Trp Arg Ile Val Lys Gly Ile Ser Asp Leu 
145                 150                 155                 160 


Glu Leu Tyr Asp Ala Gln Lys Val Lys Glu Lys Tyr Gly Val Glu Pro 
                165                 170                 175     


His Gln Ile Pro Asp Leu Leu Ala Leu Thr Gly Asp Glu Ile Asp Asn 
            180                 185                 190         


Ile Pro Gly Val Thr Gly Ile Gly Glu Lys Thr Ala Val Gln Leu Leu 
        195                 200                 205             


Glu Lys Tyr Arg Asp Leu Glu Asp Ile Leu Asn His Ile His Glu Leu 
    210                 215                 220                 


Pro Gln Lys Thr Arg Lys Thr Met Leu Arg Asp Arg Glu Ser Ala Ile 
225                 230                 235                 240 


Leu Ser Lys Lys Leu Ala Ile Leu Glu Thr Asn Val Pro Ile Glu Ile 
                245                 250                 255     


Asn Trp Glu Glu Leu Arg Tyr Gln Gly His Asp Arg Glu Lys Leu Leu 
            260                 265                 270         


Ser Leu Leu Lys Glu Leu Glu Phe Ala Ser Ile Met Lys Glu Leu Gln 
        275                 280                 285             


Leu Tyr Glu Glu Ser Glu Pro Val Gly Tyr Arg Ile Val Lys Asp Pro 
    290                 295                 300                 


Val Glu Phe Glu Lys Leu Val Glu Lys Leu Lys Glu Thr Pro Ser Phe 
305                 310                 315                 320 


Ala Ile Asp Leu Glu Thr Ser Ser Leu Asp Pro Phe Glu Cys Asp Ile 
                325                 330                 335     


Ala Gly Ile Ser Leu Ser Phe Lys Pro Lys Glu Ala Tyr Tyr Ile Pro 
            340                 345                 350         


Leu His His Arg Asn Ala Gln Asn Leu Asp Glu Lys Glu Val Leu Lys 
        355                 360                 365             


Lys Leu Lys Glu Ile Leu Glu Asp Pro Gly Ala Lys Ile Val Gly Gln 
    370                 375                 380                 


Asn Leu Lys Phe Asp Tyr Lys Val Leu Met Val Lys Gly Ile Glu Pro 
385                 390                 395                 400 


Val Pro Pro His Phe Asp Thr Met Ile Ala Ala Tyr Leu Ile Glu Pro 
                405                 410                 415     


Asn Glu Lys Lys Phe Asn Leu Asp Asp Leu Ala Leu Lys Phe Leu Gly 
            420                 425                 430         


Tyr Lys Met Thr Ser Tyr Gln Glu Leu Met Ser Phe Ser Ser Pro Leu 
        435                 440                 445             


Phe Gly Phe Ser Phe Val Asp Val Pro Leu Glu Lys Ala Ala Asn Tyr 
    450                 455                 460                 


Ser Cys Glu Asp Ala Asp Ile Thr Tyr Arg Leu Tyr Lys Thr Leu Ser 
465                 470                 475                 480 


Leu Lys Leu His Glu Ala Asp Leu Glu Asn Val Phe Tyr Lys Ile Glu 
                485                 490                 495     


Met Pro Leu Val Ser Val Leu Ala Arg Met Glu Leu Asn Gly Val Tyr 
            500                 505                 510         


Val Asp Thr Glu Phe Leu Lys Lys Leu Ser Glu Glu Tyr Gly Lys Lys 
        515                 520                 525             


Leu Glu Glu Leu Ala Glu Glu Ile Tyr Arg Ile Ala Gly Glu Pro Phe 
    530                 535                 540                 


Asn Ile Asn Ser Pro Lys Gln Val Ser Arg Ile Leu Phe Glu Lys Leu 
545                 550                 555                 560 


Gly Ile Lys Pro Arg Gly Lys Thr Thr Lys Thr Gly Asp Tyr Ser Thr 
                565                 570                 575     


Arg Ile Glu Val Leu Glu Glu Leu Ala Gly Glu His Glu Ile Ile Pro 
            580                 585                 590         


Leu Ile Leu Glu Tyr Arg Lys Ile Gln Lys Leu Lys Ser Thr Tyr Ile 
        595                 600                 605             


Asp Ala Leu Pro Lys Met Val Asn Pro Lys Thr Gly Arg Ile His Ala 
    610                 615                 620                 


Ser Phe Asn Gln Thr Gly Thr Ala Thr Gly Arg Leu Ser Ser Ser Asp 
625                 630                 635                 640 


Pro Asn Leu Gln Asn Leu Pro Thr Lys Ser Glu Glu Gly Lys Glu Ile 
                645                 650                 655     


Arg Lys Ala Ile Val Pro Gln Asp Pro Asn Trp Trp Ile Val Ser Ala 
            660                 665                 670         


Asp Tyr Ser Gln Ile Glu Leu Arg Ile Leu Ala His Leu Ser Gly Asp 
        675                 680                 685             


Glu Asn Leu Leu Arg Ala Phe Glu Glu Gly Ile Asp Val His Thr Leu 
    690                 695                 700                 


Thr Ala Ser Arg Ile Phe Asn Val Lys Pro Glu Glu Val Thr Glu Glu 
705                 710                 715                 720 


Met Arg Arg Ala Gly Lys Met Val Asn Phe Ser Ile Ile Tyr Gly Val 
                725                 730                 735     


Thr Pro Tyr Gly Leu Ser Val Arg Leu Gly Val Pro Val Lys Glu Ala 
            740                 745                 750         


Glu Lys Met Ile Val Asn Tyr Phe Val Leu Tyr Pro Lys Val Arg Asp 
        755                 760                 765             


Tyr Ile Gln Arg Val Val Ser Glu Ala Lys Glu Lys Gly Tyr Val Arg 
    770                 775                 780                 


Thr Leu Phe Gly Arg Lys Arg Asp Ile Pro Gln Leu Met Ala Arg Asp 
785                 790                 795                 800 


Arg Asn Thr Gln Ala Glu Gly Glu Arg Ile Ala Ile Asn Thr Pro Ile 
                805                 810                 815     


Gln Gly Thr Ala Ala Asp Ile Ile Lys Leu Ala Met Ile Glu Ile Asp 
            820                 825                 830         


Arg Glu Leu Lys Glu Arg Lys Met Arg Ser Lys Met Ile Ile Gln Val 
        835                 840                 845             


His Asp Glu Leu Val Phe Glu Val Pro Asn Glu Glu Lys Asp Ala Leu 
    850                 855                 860                 


Val Glu Leu Val Lys Asp Arg Met Thr Asn Val Val Lys Leu Ser Val 
865                 870                 875                 880 


Pro Leu Glu Val Asp Val Thr Ile Gly Lys Thr Trp Ser 
                885                 890             


<210>  11
<211>  893
<212>  PRT
<213>  Thermotoga maritima MSB8

<400>  11

Met Ala Arg Leu Phe Leu Phe Asp Gly Thr Ala Leu Ala Tyr Arg Ala 
1               5                   10                  15      


Tyr Tyr Ala Leu Asp Arg Ser Leu Ser Thr Ser Thr Gly Ile Pro Thr 
            20                  25                  30          


Asn Ala Thr Tyr Gly Val Ala Arg Met Leu Val Arg Phe Ile Lys Asp 
        35                  40                  45              


His Ile Ile Val Gly Lys Asp Tyr Val Ala Val Ala Phe Asp Lys Lys 
    50                  55                  60                  


Ala Ala Thr Phe Arg His Lys Leu Leu Glu Thr Tyr Lys Ala Gln Arg 
65                  70                  75                  80  


Pro Lys Thr Pro Asp Leu Leu Ile Gln Gln Leu Pro Tyr Ile Lys Lys 
                85                  90                  95      


Leu Val Glu Ala Leu Gly Met Lys Val Leu Glu Val Glu Gly Tyr Glu 
            100                 105                 110         


Ala Asp Asp Ile Ile Ala Thr Leu Ala Val Lys Gly Leu Pro Leu Phe 
        115                 120                 125             


Asp Glu Ile Phe Ile Val Thr Gly Asp Lys Asp Met Leu Gln Leu Val 
    130                 135                 140                 


Asn Glu Lys Ile Lys Val Trp Arg Ile Val Lys Gly Ile Ser Asp Leu 
145                 150                 155                 160 


Glu Leu Tyr Asp Ala Gln Lys Val Lys Glu Lys Tyr Gly Val Glu Pro 
                165                 170                 175     


Gln Gln Ile Pro Asp Leu Leu Ala Leu Thr Gly Asp Glu Ile Asp Asn 
            180                 185                 190         


Ile Pro Gly Val Thr Gly Ile Gly Glu Lys Thr Ala Val Gln Leu Leu 
        195                 200                 205             


Glu Lys Tyr Lys Asp Leu Glu Asp Ile Leu Asn His Val Arg Glu Leu 
    210                 215                 220                 


Pro Gln Lys Val Arg Lys Ala Leu Leu Arg Asp Arg Glu Asn Ala Ile 
225                 230                 235                 240 


Leu Ser Lys Lys Leu Ala Ile Leu Glu Thr Asn Val Pro Ile Glu Ile 
                245                 250                 255     


Asn Trp Glu Glu Leu Arg Tyr Gln Gly Tyr Asp Arg Glu Lys Leu Leu 
            260                 265                 270         


Pro Leu Leu Lys Glu Leu Glu Phe Ala Ser Ile Met Lys Glu Leu Gln 
        275                 280                 285             


Leu Tyr Glu Glu Ser Glu Pro Val Gly Tyr Arg Ile Val Lys Asp Leu 
    290                 295                 300                 


Val Glu Phe Glu Lys Leu Ile Glu Lys Leu Arg Glu Ser Pro Ser Phe 
305                 310                 315                 320 


Ala Ile Asp Leu Glu Thr Ser Ser Leu Asp Pro Phe Asp Cys Asp Ile 
                325                 330                 335     


Val Gly Ile Ser Val Ser Phe Lys Pro Lys Glu Ala Tyr Tyr Ile Pro 
            340                 345                 350         


Leu His His Arg Asn Ala Gln Asn Leu Asp Glu Lys Glu Val Leu Lys 
        355                 360                 365             


Lys Leu Lys Glu Ile Leu Glu Asp Pro Gly Ala Lys Ile Val Gly Gln 
    370                 375                 380                 


Asn Leu Lys Phe Asp Tyr Lys Val Leu Met Val Lys Gly Val Glu Pro 
385                 390                 395                 400 


Val Pro Pro Tyr Phe Asp Thr Met Ile Ala Ala Tyr Leu Leu Glu Pro 
                405                 410                 415     


Asn Glu Lys Lys Phe Asn Leu Asp Asp Leu Ala Leu Lys Phe Leu Gly 
            420                 425                 430         


Tyr Lys Met Thr Ser Tyr Gln Glu Leu Met Ser Phe Ser Phe Pro Leu 
        435                 440                 445             


Phe Gly Phe Ser Phe Ala Asp Val Pro Val Glu Lys Ala Ala Asn Tyr 
    450                 455                 460                 


Ser Cys Glu Asp Ala Asp Ile Thr Tyr Arg Leu Tyr Lys Thr Leu Ser 
465                 470                 475                 480 


Leu Lys Leu His Glu Ala Asp Leu Glu Asn Val Phe Tyr Lys Ile Glu 
                485                 490                 495     


Met Pro Leu Val Asn Val Leu Ala Arg Met Glu Leu Asn Gly Val Tyr 
            500                 505                 510         


Val Asp Thr Glu Phe Leu Lys Lys Leu Ser Glu Glu Tyr Gly Lys Lys 
        515                 520                 525             


Leu Glu Glu Leu Ala Glu Glu Ile Tyr Arg Ile Ala Gly Glu Pro Phe 
    530                 535                 540                 


Asn Ile Asn Ser Pro Lys Gln Val Ser Arg Ile Leu Phe Glu Lys Leu 
545                 550                 555                 560 


Gly Ile Lys Pro Arg Gly Lys Thr Thr Lys Thr Gly Asp Tyr Ser Thr 
                565                 570                 575     


Arg Ile Glu Val Leu Glu Glu Leu Ala Gly Glu His Glu Ile Ile Pro 
            580                 585                 590         


Leu Ile Leu Glu Tyr Arg Lys Ile Gln Lys Leu Lys Ser Thr Tyr Ile 
        595                 600                 605             


Asp Ala Leu Pro Lys Met Val Asn Pro Lys Thr Gly Arg Ile His Ala 
    610                 615                 620                 


Ser Phe Asn Gln Thr Gly Thr Ala Thr Gly Arg Leu Ser Ser Ser Asp 
625                 630                 635                 640 


Pro Asn Leu Gln Asn Leu Pro Thr Lys Ser Glu Glu Gly Lys Glu Ile 
                645                 650                 655     


Arg Lys Ala Ile Val Pro Gln Asp Pro Asn Trp Trp Ile Val Ser Ala 
            660                 665                 670         


Asp Tyr Ser Gln Ile Glu Leu Arg Ile Leu Ala His Leu Ser Gly Asp 
        675                 680                 685             


Glu Asn Leu Leu Arg Ala Phe Glu Glu Gly Ile Asp Val His Thr Leu 
    690                 695                 700                 


Thr Ala Ser Arg Ile Phe Asn Val Lys Pro Glu Glu Val Thr Glu Glu 
705                 710                 715                 720 


Met Arg Arg Ala Gly Lys Met Val Asn Phe Ser Ile Ile Tyr Gly Val 
                725                 730                 735     


Thr Pro Tyr Gly Leu Ser Val Arg Leu Gly Val Pro Val Lys Glu Ala 
            740                 745                 750         


Glu Lys Met Ile Val Asn Tyr Phe Val Leu Tyr Pro Lys Val Arg Asp 
        755                 760                 765             


Tyr Ile Gln Arg Val Val Ser Glu Ala Lys Glu Lys Gly Tyr Val Arg 
    770                 775                 780                 


Thr Leu Phe Gly Arg Lys Arg Asp Ile Pro Gln Leu Met Ala Arg Asp 
785                 790                 795                 800 


Arg Asn Thr Gln Ala Glu Gly Glu Arg Ile Ala Ile Asn Thr Pro Ile 
                805                 810                 815     


Gln Gly Thr Ala Ala Asp Ile Ile Lys Leu Ala Met Ile Glu Ile Asp 
            820                 825                 830         


Arg Glu Leu Lys Glu Arg Lys Met Arg Ser Lys Met Ile Ile Gln Val 
        835                 840                 845             


His Asp Glu Leu Val Phe Glu Val Pro Asn Glu Glu Lys Asp Ala Leu 
    850                 855                 860                 


Val Glu Leu Val Lys Asp Arg Met Thr Asn Val Val Lys Leu Ser Val 
865                 870                 875                 880 


Pro Leu Glu Val Asp Val Thr Ile Gly Lys Thr Trp Ser 
                885                 890             


<210>  12
<211>  890
<212>  PRT
<213>  Thermosipho melanesiensis BI429

<400>  12

Met Arg Glu Leu Phe Leu Phe Asp Gly Thr Gly Leu Val Tyr Arg Ala 
1               5                   10                  15      


Phe Tyr Ala Ile Asp Gln Phe Leu Lys Thr Ser Thr Gly Met His Thr 
            20                  25                  30          


Asn Ala Leu Tyr Gly Ile Ala Lys Met Leu Ile Lys Phe Leu Lys Glu 
        35                  40                  45              


His Val Asn Met Glu Lys Asp Ala Cys Ala Phe Ile Leu Asp Ser Lys 
    50                  55                  60                  


Gly Gly Ser Lys Lys Arg Lys Glu Ile Leu Lys Asp Tyr Lys Ser Asn 
65                  70                  75                  80  


Arg Pro Glu Thr Pro Asp Leu Ile Leu Glu Gln Leu Pro Tyr Ile Glu 
                85                  90                  95      


Glu Phe Val Asp Ala Phe Gly Val Lys Val Leu Lys Leu Leu Gly Tyr 
            100                 105                 110         


Glu Ala Asp Asp Ile Ile Ala Thr Ile Ala Lys Arg Phe Cys Asn Ala 
        115                 120                 125             


Phe Glu Lys Val Asn Ile Ile Thr Gly Asp Lys Asp Leu Leu Gln Leu 
    130                 135                 140                 


Val Asp Glu Lys Val Tyr Val Trp Arg Ile Glu Arg Gly Ile Thr Glu 
145                 150                 155                 160 


Leu Val Leu Tyr Asp Arg Lys Lys Val Phe Glu Lys Tyr Gly Val Phe 
                165                 170                 175     


Pro Glu Gln Phe Gly Asp Tyr Leu Ser Leu Val Gly Asp Gln Ile Asp 
            180                 185                 190         


Asn Ile Pro Gly Val Lys Gly Ile Gly Lys Lys Thr Ala Val Ser Leu 
        195                 200                 205             


Leu Lys Lys Tyr Gly Thr Ile Asp Glu Val Leu Lys Asn Lys Lys Leu 
    210                 215                 220                 


Leu Thr Glu Lys Leu Gln Lys Leu Leu Glu Asn Ala Thr Glu Ser Leu 
225                 230                 235                 240 


Glu Lys Ser Arg Gln Leu Val Gln Leu Ile Tyr Asp Val Pro Leu Asp 
                245                 250                 255     


Val Asn Ile Glu Asp Leu Ile Tyr Lys Gly Tyr Asp Ser Lys Lys Leu 
            260                 265                 270         


Leu Val Val Leu Lys Lys Tyr Glu Phe Ser Ser Ile Ile Lys Glu Leu 
        275                 280                 285             


Gly Leu Lys Glu Glu Phe Glu Lys Lys Tyr Thr Ile Val Asn Ser Glu 
    290                 295                 300                 


Lys Glu Leu Ser Lys Leu Arg Lys Arg Ile Asp Glu Val Lys Thr Phe 
305                 310                 315                 320 


Ser Ile Asp Thr Glu Thr Thr Ser Leu Asp Pro Phe Ser Ala Lys Leu 
                325                 330                 335     


Val Gly Val Ser Ile Ser Thr Asn Glu Gly Glu Ala Tyr Tyr Ile Pro 
            340                 345                 350         


Ile Ser His Val Ser Glu Asn Asn Leu Thr Lys Glu Ile Val Leu Lys 
        355                 360                 365             


Phe Leu Lys Glu Ile Leu Glu Cys Glu Arg Tyr Asn Ile Val Gly Gln 
    370                 375                 380                 


Asn Leu Lys Phe Asp Tyr Lys Val Phe Met Val Asn Gly Ile Glu Pro 
385                 390                 395                 400 


Gln Ile Pro His Phe Asp Thr Met Val Ala Ala Tyr Leu Ile Asn Pro 
                405                 410                 415     


Glu Glu Arg Arg Tyr Asn Leu Glu Glu Leu Ala Leu Lys Tyr Leu Gly 
            420                 425                 430         


Tyr Lys Met Ile Ser Phe Glu Glu Leu Val Asp Asn Asn Met Pro Leu 
        435                 440                 445             


Phe Gly Asn Asp Phe Ser Phe Ile Ser Ile Glu Lys Ala Ala Glu Tyr 
    450                 455                 460                 


Ser Cys Glu Asp Val Asp Ile Thr Phe Arg Leu Tyr Ser Tyr Leu Ser 
465                 470                 475                 480 


Lys Tyr Ile Gly Glu Met Lys Glu Leu Phe Tyr Asn Ile Glu Met Pro 
                485                 490                 495     


Leu Ile Asn Val Leu Ala Gln Met Glu Leu Asn Gly Val Tyr Phe Asp 
            500                 505                 510         


Val Asp Tyr Leu Lys Glu Leu Ser Lys Arg Tyr Glu Glu Glu Met Lys 
        515                 520                 525             


Lys Leu Glu Glu Lys Ile Phe Glu Ile Ser Gly Glu Gln Phe Asn Ile 
    530                 535                 540                 


Asn Ser Ser Lys Gln Val Ala Glu Ile Leu Phe Glu Lys Leu Lys Leu 
545                 550                 555                 560 


Pro Ile Val Lys Lys Thr Ala Thr Gly Arg Asn Ser Thr Asn Ala Glu 
                565                 570                 575     


Val Leu Glu Glu Leu Ala Lys Asp Tyr Glu Ile Ala Arg Leu Ile Leu 
            580                 585                 590         


Glu Tyr Arg Lys Phe Gln Lys Leu Lys Ser Thr Tyr Val Asp Ser Ile 
        595                 600                 605             


Pro Ser Ser Val Asn Ile Thr Thr Asn Arg Val His Ser Ser Phe His 
    610                 615                 620                 


Gln Thr Gly Thr Ser Thr Gly Arg Leu Ser Ser Ser Ala Pro Asn Leu 
625                 630                 635                 640 


Gln Asn Leu Pro Thr Arg Ser Glu Glu Gly Lys Glu Ile Arg His Ala 
                645                 650                 655     


Val Lys Pro Gln Phe Glu Asn Trp Tyr Ile Val Gly Ala Asp Tyr Ser 
            660                 665                 670         


Gln Ile Glu Leu Arg Val Leu Ala His Met Ser Glu Asp Glu Lys Leu 
        675                 680                 685             


Leu Asp Ala Phe Glu Asn Asp Tyr Asp Ile His Thr Ile Thr Ala Ser 
    690                 695                 700                 


Lys Ile Phe Asn Val Ser Glu Leu Met Val Thr Glu Asp Met Arg Arg 
705                 710                 715                 720 


Ile Gly Lys Met Ile Asn Phe Ala Ile Ile Tyr Gly Ile Ser Pro Tyr 
                725                 730                 735     


Gly Leu Ser Arg Arg Ile Gly Leu Asn Val Asn Glu Thr Lys Lys Ile 
            740                 745                 750         


Ile Asp Asn Tyr Phe Lys Tyr Tyr Gln Gly Val Phe Glu Phe Ile Lys 
        755                 760                 765             


Lys Thr Ile Asp Phe Ala Lys Lys Asn Gly Phe Val Lys Thr Leu Phe 
    770                 775                 780                 


Gly Arg Lys Arg Phe Ile Pro Gln Leu Lys Leu Lys Asn Lys Asn Leu 
785                 790                 795                 800 


Ile Gln Glu Gly Glu Arg Ile Ala Ile Asn Thr Pro Val Gln Gly Thr 
                805                 810                 815     


Ala Ala Asp Ile Ile Lys Ile Ala Met Val Lys Val His Asn Glu Leu 
            820                 825                 830         


Lys Arg Asn Ser Leu Lys Thr Lys Leu Ile Leu Gln Val His Asp Glu 
        835                 840                 845             


Leu Val Phe Glu Val Pro Phe Asp Glu Leu Gln Ile Val Lys Glu Ile 
    850                 855                 860                 


Ile Lys Asp Lys Met Glu Asn Ala Val Lys Leu Lys Val Pro Leu Lys 
865                 870                 875                 880 


Val Asp Leu Tyr Glu Gly Arg Glu Trp Glu 
                885                 890 


<210>  13
<211>  876
<212>  PRT
<213>  Geobacillus sp. MKK-2005

<400>  13

Met Lys Asn Lys Leu Val Leu Ile Asp Gly Asn Ser Val Ala Tyr Arg 
1               5                   10                  15      


Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 
            20                  25                  30          


Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 
        35                  40                  45              


Glu Arg Pro Thr His Leu Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 
    50                  55                  60                  


Phe Arg His Glu Thr Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 
65                  70                  75                  80  


Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Asn 
                85                  90                  95      


Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Asp Arg Tyr Glu Ala Asp Asp 
            100                 105                 110         


Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 
        115                 120                 125             


Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 
    130                 135                 140                 


Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 
145                 150                 155                 160 


Thr Pro Glu Thr Val Glu Glu Lys Tyr Gly Leu Thr Pro Glu Gln Met 
                165                 170                 175     


Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Lys Gln Phe 
        195                 200                 205             


Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 
    210                 215                 220                 


Lys Leu Lys Glu Asn Leu Arg Gln Tyr Arg Asp Leu Ala Leu Leu Ser 
225                 230                 235                 240 


Lys Gln Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 
                245                 250                 255     


Asp Asp Ile Ile Tyr Glu Gly Gln Asp Arg Glu Lys Val Ile Ala Leu 
            260                 265                 270         


Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Asp Ala Pro 
        275                 280                 285             


Thr Ala Glu Asp Glu Thr Pro Leu Met Glu Met Glu Phe Val Ile Ala 
    290                 295                 300                 


Asp Gly Ile Thr Asp Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 
305                 310                 315                 320 


Glu Val Met Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 
                325                 330                 335     


Leu Val Asn Glu His Gly Arg Phe Phe Leu Arg Ala Glu Met Ala Leu 
            340                 345                 350         


Ala Asp Ser Gln Phe Leu Ala Trp Leu Ala Asp Glu Thr Lys Lys Lys 
        355                 360                 365             


Ser Met Phe Asp Ala Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 
    370                 375                 380                 


Ile Glu Leu Arg Gly Val Ala Phe Asp Leu Leu Leu Ala Ala Tyr Leu 
385                 390                 395                 400 


Leu Asn Pro Ala Gln Asp Ala Gly Asp Val Ala Ala Val Ala Lys Met 
                405                 410                 415     


Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 
            420                 425                 430         


Ala Lys Arg Ser Leu Pro Asp Glu Pro Thr Leu Ala Glu His Leu Val 
        435                 440                 445             


Arg Lys Ala Ala Ala Ile Trp Ala Leu Glu Arg Pro Phe Leu Asp Glu 
    450                 455                 460                 


Leu Arg Ser Asn Glu Gln Asp Gly Leu Leu Ile Lys Leu Glu Gln Pro 
465                 470                 475                 480 


Leu Ala Thr Ile Leu Ala Glu Met Glu Phe Thr Gly Ile Lys Val Asp 
                485                 490                 495     


Thr Lys Arg Leu Glu Gln Met Gly Ser Glu Leu Ala Glu Gln Leu Arg 
            500                 505                 510         


Ala Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 
        515                 520                 525             


Asn Ser Pro Lys Gln Leu Gly Ile Ile Leu Phe Glu Lys Leu Gln Leu 
    530                 535                 540                 


Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 
545                 550                 555                 560 


Leu Glu Lys Leu Ala Pro His His Glu Ile Val Glu Asn Ile Leu His 
                565                 570                 575     


Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 
            580                 585                 590         


Lys Val Val His Pro Asp Thr Gly Lys Val His Thr Met Phe Asn Gln 
        595                 600                 605             


Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Ala Glu Pro Asn Leu Gln 
    610                 615                 620                 


Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 
625                 630                 635                 640 


Val Pro Ser Glu Pro Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 
                645                 650                 655     


Ile Glu Leu Arg Val Leu Ala His Ile Ala Asp Asp Asp Asn Leu Ile 
            660                 665                 670         


Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 
        675                 680                 685             


Ile Phe His Val Ser Glu Glu Glu Val Thr Ala Thr Met Arg Arg Gln 
    690                 695                 700                 


Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Asp Tyr Gly 
705                 710                 715                 720 


Leu Ala Gln Asn Leu Asn Ile Thr Arg Lys Glu Ala Ala Glu Phe Ile 
                725                 730                 735     


Glu Arg Tyr Phe Ala Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Thr 
            740                 745                 750         


Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 
        755                 760                 765             


Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Asn Val Arg 
    770                 775                 780                 


Ser Phe Ala Glu Arg Thr Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 
785                 790                 795                 800 


Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Ala Ala Arg Leu Lys 
                805                 810                 815     


Glu Glu Arg Leu Gln Ala Arg Leu Leu Leu Gln Val His Asp Glu Leu 
            820                 825                 830         


Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Gln Leu Val 
        835                 840                 845             


Pro Glu Val Met Glu Gln Ala Val Ala Leu Arg Val Pro Leu Lys Val 
    850                 855                 860                 


Asp Tyr His Tyr Gly Pro Thr Trp Tyr Asp Ala Lys 
865                 870                 875     


<210>  14
<211>  877
<212>  PRT
<213>  Bacillus caldotenax

<400>  14

Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 
1               5                   10                  15      


Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 
            20                  25                  30          


Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 
        35                  40                  45              


Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 
    50                  55                  60                  


Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 
65                  70                  75                  80  


Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 
                85                  90                  95      


Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 
            100                 105                 110         


Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 
        115                 120                 125             


Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 
    130                 135                 140                 


Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 
145                 150                 155                 160 


Thr Pro Glu Ala Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 
                165                 170                 175     


Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 
        195                 200                 205             


Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 
    210                 215                 220                 


Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 
225                 230                 235                 240 


Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 
                245                 250                 255     


Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 
            260                 265                 270         


Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 
        275                 280                 285             


Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 
    290                 295                 300                 


Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 
305                 310                 315                 320 


Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 
                325                 330                 335     


Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 
            340                 345                 350         


Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 
        355                 360                 365             


Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 
    370                 375                 380                 


Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 
385                 390                 395                 400 


Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 
                405                 410                 415     


Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 
            420                 425                 430         


Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 
        435                 440                 445             


Arg Lys Ala Ala Ala Ile Trp Ala Leu Glu Arg Pro Phe Leu Asp Glu 
    450                 455                 460                 


Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 
465                 470                 475                 480 


Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 
                485                 490                 495     


Thr Lys Arg Leu Glu Gln Met Gly Glu Glu Leu Ala Glu Gln Leu Arg 
            500                 505                 510         


Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 
        515                 520                 525             


Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 
    530                 535                 540                 


Pro Val Leu Lys Lys Ser Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 
545                 550                 555                 560 


Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Gln 
                565                 570                 575     


His Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu 
            580                 585                 590         


Leu Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn 
        595                 600                 605             


Gln Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu 
    610                 615                 620                 


Gln Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala 
625                 630                 635                 640 


Phe Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser 
                645                 650                 655     


Gln Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu 
            660                 665                 670         


Met Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met 
        675                 680                 685             


Asp Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg 
    690                 695                 700                 


Gln Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Asp Tyr 
705                 710                 715                 720 


Gly Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe 
                725                 730                 735     


Ile Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu 
            740                 745                 750         


Asn Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu 
        755                 760                 765             


His Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Asn Val 
    770                 775                 780                 


Arg Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser 
785                 790                 795                 800 


Ala Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu 
                805                 810                 815     


Lys Glu Glu Arg Leu Gln Ala Arg Leu Leu Leu Gln Val His Asp Glu 
            820                 825                 830         


Leu Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu 
        835                 840                 845             


Val Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys 
    850                 855                 860                 


Val Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 
865                 870                 875         


<210>  15
<211>  872
<212>  PRT
<213>  Bacillus caldontenax

<400>  15

Met Tyr Lys Phe Leu Ile Ile Asp Gly Ser Ser Leu Met Tyr Arg Ala 
1               5                   10                  15      


Tyr Tyr Ala Leu Pro Met Leu Thr Thr Ser Glu Gly Leu Pro Thr Asn 
            20                  25                  30          


Ala Leu Tyr Gly Phe Thr Met Met Leu Ile Lys Leu Ile Glu Glu Glu 
        35                  40                  45              


Lys Pro Asp Tyr Ile Ala Ile Ala Phe Asp Lys Lys Ala Pro Thr Phe 
    50                  55                  60                  


Arg His Lys Glu Tyr Gln Asp Tyr Lys Ala Thr Arg Gln Ala Met Pro 
65                  70                  75                  80  


Glu Glu Leu Ala Glu Gln Val Asp Tyr Leu Lys Glu Ile Ile Asp Gly 
                85                  90                  95      


Phe Asn Ile Lys Thr Leu Glu Leu Glu Gly Tyr Glu Ala Asp Asp Ile 
            100                 105                 110         


Ile Gly Thr Ile Ser Lys Leu Ala Glu Glu Lys Gly Met Glu Val Leu 
        115                 120                 125             


Val Val Thr Gly Asp Arg Asp Ala Leu Gln Leu Val Ser Asp Lys Val 
    130                 135                 140                 


Lys Ile Lys Ile Ser Lys Lys Gly Ile Thr Gln Met Glu Glu Phe Asp 
145                 150                 155                 160 


Glu Lys Ala Ile Leu Glu Arg Tyr Gly Ile Thr Pro Gln Gln Phe Ile 
                165                 170                 175     


Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly Val 
            180                 185                 190         


Pro Asn Ile Gly Glu Lys Thr Ala Ile Lys Leu Leu Lys Asp Phe Gly 
        195                 200                 205             


Thr Ile Glu Asn Leu Ile Gln Asn Leu Ser Gln Leu Lys Gly Lys Ile 
    210                 215                 220                 


Lys Glu Asn Ile Glu Asn Asn Lys Glu Leu Ala Ile Met Ser Lys Arg 
225                 230                 235                 240 


Leu Ala Thr Ile Lys Arg Asp Ile Pro Ile Glu Ile Asp Phe Glu Glu 
                245                 250                 255     


Tyr Lys Val Lys Lys Phe Asn Glu Glu Lys Leu Leu Glu Leu Phe Asn 
            260                 265                 270         


Lys Leu Glu Phe Phe Ser Leu Ile Asp Asn Ile Lys Lys Glu Ser Ser 
        275                 280                 285             


Ile Glu Ile Val Asp Asn His Lys Val Glu Lys Trp Ser Lys Val Asp 
    290                 295                 300                 


Ile Lys Glu Leu Val Thr Leu Leu Gln Asp Asn Arg Asn Ile Ala Phe 
305                 310                 315                 320 


Tyr Pro Leu Ile Tyr Glu Gly Glu Ile Lys Lys Ile Ala Phe Ser Phe 
                325                 330                 335     


Gly Lys Asp Thr Val Tyr Ile Asp Val Phe Gln Thr Glu Asp Leu Lys 
            340                 345                 350         


Glu Ile Phe Glu Lys Glu Asp Phe Glu Phe Thr Thr His Glu Ile Lys 
        355                 360                 365             


Asp Phe Leu Val Arg Leu Ser Tyr Lys Gly Ile Glu Cys Lys Ser Lys 
    370                 375                 380                 


Tyr Ile Asp Thr Ala Val Met Ala Tyr Leu Leu Asn Pro Ser Glu Ser 
385                 390                 395                 400 


Asn Tyr Asp Leu Asp Arg Val Leu Lys Lys Tyr Leu Lys Val Asp Val 
                405                 410                 415     


Pro Ser Tyr Glu Gly Ile Phe Gly Lys Gly Arg Asp Lys Lys Lys Ile 
            420                 425                 430         


Glu Glu Ile Asp Glu Asn Ile Leu Ala Asp Tyr Ile Cys Ser Arg Cys 
        435                 440                 445             


Val Tyr Leu Phe Asp Leu Lys Glu Lys Leu Met Asn Phe Ile Glu Glu 
    450                 455                 460                 


Met Asp Met Lys Lys Leu Leu Leu Glu Ile Glu Met Pro Leu Val Glu 
465                 470                 475                 480 


Val Leu Lys Ser Met Glu Val Ser Gly Phe Thr Leu Asp Lys Glu Val 
                485                 490                 495     


Leu Lys Glu Leu Ser Gln Lys Ile Asp Asp Arg Ile Gly Glu Ile Leu 
            500                 505                 510         


Asp Lys Ile Tyr Lys Glu Ala Gly Tyr Gln Phe Asn Val Asn Ser Pro 
        515                 520                 525             


Lys Gln Leu Ser Glu Phe Leu Phe Glu Lys Leu Asn Leu Pro Val Ile 
    530                 535                 540                 


Lys Lys Thr Lys Thr Gly Tyr Ser Thr Asp Ser Glu Val Leu Glu Gln 
545                 550                 555                 560 


Leu Val Pro Tyr Asn Asp Ile Val Ser Asp Ile Ile Glu Tyr Arg Gln 
                565                 570                 575     


Leu Thr Lys Leu Lys Ser Thr Tyr Ile Asp Gly Phe Leu Pro Leu Met 
            580                 585                 590         


Asp Glu Asn Asn Arg Val His Ser Asn Phe Lys Gln Met Val Thr Ala 
        595                 600                 605             


Thr Gly Arg Ile Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile 
    610                 615                 620                 


Arg Glu Glu Phe Gly Arg Gln Ile Arg Arg Ala Phe Ile Pro Arg Ser 
625                 630                 635                 640 


Arg Asp Gly Tyr Ile Val Ser Ala Asp Tyr Ser Gln Ile Glu Leu Arg 
                645                 650                 655     


Val Leu Ala His Val Ser Gly Asp Glu Lys Leu Ile Glu Ser Phe Met 
            660                 665                 670         


Asn Asn Glu Asp Ile His Leu Arg Thr Ala Ser Glu Val Phe Lys Val 
        675                 680                 685             


Pro Met Glu Lys Val Thr Pro Glu Met Arg Arg Ala Ala Lys Ala Val 
    690                 695                 700                 


Asn Phe Gly Ile Ile Tyr Gly Ile Ser Asp Tyr Gly Leu Ser Arg Asp 
705                 710                 715                 720 


Leu Lys Ile Ser Arg Lys Glu Ala Lys Glu Tyr Ile Asn Asn Tyr Phe 
                725                 730                 735     


Glu Arg Tyr Lys Gly Val Lys Asp Tyr Ile Glu Lys Ile Val Arg Phe 
            740                 745                 750         


Ala Lys Glu Asn Gly Tyr Val Thr Thr Ile Met Asn Arg Arg Arg Tyr 
        755                 760                 765             


Ile Pro Glu Ile Asn Ser Arg Asn Phe Thr Gln Arg Ser Gln Ala Glu 
    770                 775                 780                 


Arg Leu Ala Met Asn Ala Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile 
785                 790                 795                 800 


Lys Met Ala Met Val Lys Val Tyr Asn Asp Leu Lys Lys Leu Lys Leu 
                805                 810                 815     


Lys Ser Lys Leu Ile Leu Gln Val His Asp Glu Leu Val Val Asp Thr 
            820                 825                 830         


Tyr Lys Asp Glu Val Asp Ile Ile Lys Lys Ile Leu Lys Glu Asn Met 
        835                 840                 845             


Glu Asn Val Val Gln Leu Lys Val Pro Leu Val Val Glu Ile Gly Val 
    850                 855                 860                 


Gly Pro Asn Trp Phe Leu Ala Lys 
865                 870         


<210>  16
<211>  872
<212>  PRT
<213>  Thermoanaerobacter pseudethanolicus ATCC 33223

<400>  16

Met Ser Lys Phe Leu Val Ile Asp Gly Ser Ser Leu Met Tyr Arg Ala 
1               5                   10                  15      


Tyr Tyr Ala Leu Pro Met Leu Thr Thr Ser Glu Gly Leu His Thr Asn 
            20                  25                  30          


Ala Leu Tyr Gly Phe Thr Met Met Leu Ile Lys Leu Ile Glu Glu Glu 
        35                  40                  45              


Lys Pro Asp Tyr Ile Ala Ile Ala Phe Asp Lys Lys Ala Pro Thr Phe 
    50                  55                  60                  


Arg His Lys Glu Tyr Gln Asp Tyr Lys Ala Thr Arg Gln Ala Met Pro 
65                  70                  75                  80  


Glu Glu Leu Ala Glu Gln Val Asp Leu Leu Lys Glu Ile Ile Glu Gly 
                85                  90                  95      


Phe Asn Ile Lys Ile Leu Glu Leu Glu Gly Tyr Glu Ala Asp Asp Ile 
            100                 105                 110         


Ile Gly Thr Ile Ser Lys Leu Ala Glu Glu Lys Glu Met Glu Val Leu 
        115                 120                 125             


Val Val Thr Gly Asp Arg Asp Ala Leu Gln Leu Val Ser Asp Lys Val 
    130                 135                 140                 


Lys Val Lys Ile Ser Lys Lys Gly Ile Thr Gln Met Glu Glu Phe Asp 
145                 150                 155                 160 


Glu Lys Ala Val Leu Glu Arg Tyr Glu Ile Thr Pro His Gln Phe Ile 
                165                 170                 175     


Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly Ile 
            180                 185                 190         


Pro Asn Ile Gly Glu Lys Thr Ala Ile Lys Leu Leu Lys Asp Phe Gly 
        195                 200                 205             


Thr Ile Glu Asn Leu Leu Gln Asn Leu Ser Gln Leu Lys Gly Lys Ile 
    210                 215                 220                 


Lys Glu Asn Ile Glu Asn Asn Lys Glu Leu Ala Ile Met Ser Lys Lys 
225                 230                 235                 240 


Leu Ala Thr Ile Lys Arg Asp Ile Pro Ile Glu Ile Asp Phe Glu Glu 
                245                 250                 255     


Tyr Arg Val Lys Asp Phe Asn Glu Glu Lys Leu Leu Glu Leu Phe Asn 
            260                 265                 270         


Lys Leu Glu Phe Phe Ser Leu Ile Asp Ser Ile Lys Lys Lys Asn Asn 
        275                 280                 285             


Val Glu Ile Val Asn Asn His Lys Val Gln Lys Trp Ser Lys Val Asp 
    290                 295                 300                 


Ile Lys Lys Leu Ile Ala Leu Leu Gln Asp Ser Lys Ser Ile Ala Phe 
305                 310                 315                 320 


Tyr Pro Leu Ile Tyr Glu Gly Glu Ile Lys Lys Ile Ala Phe Ser Phe 
                325                 330                 335     


Gly Asn Asp Thr Val Tyr Ile Asp Gly Phe Gln Ile Lys Asp Leu Lys 
            340                 345                 350         


Glu Ile Phe Glu Lys Glu Lys Phe Glu Phe Thr Thr His Glu Ile Lys 
        355                 360                 365             


Asp Phe Leu Val Lys Leu Ser Tyr Lys Gly Ile Glu Cys Lys Ser Lys 
    370                 375                 380                 


Tyr Met Asp Thr Ala Ile Met Ala Tyr Leu Leu Asn Pro Ser Glu Ser 
385                 390                 395                 400 


Asn Tyr Asp Leu Asp Arg Val Leu Lys Lys Tyr Leu Lys Val Asp Val 
                405                 410                 415     


Pro Ser Tyr Glu Glu Val Phe Gly Lys Gly Arg Asp Lys Lys Lys Leu 
            420                 425                 430         


Glu Glu Ile Gly Glu Asp Ile Leu Ala Asp Tyr Ile Cys Ser Arg Cys 
        435                 440                 445             


Val His Leu Phe Asp Leu Arg Glu Lys Leu Met Asn Phe Ile Glu Glu 
    450                 455                 460                 


Met Asp Met Lys Arg Leu Leu Leu Glu Ile Glu Met Pro Leu Val Glu 
465                 470                 475                 480 


Val Leu Lys Ser Met Glu Val Ser Gly Phe Thr Leu Asp Lys Glu Val 
                485                 490                 495     


Leu Lys Glu Leu Ser Gln Lys Ile Asn Asp Arg Ile Ala Glu Ile Leu 
            500                 505                 510         


Asp Lys Ile Tyr Lys Glu Ala Gly Tyr Gln Phe Asn Val Asn Ser Pro 
        515                 520                 525             


Lys Gln Leu Ser Glu Phe Leu Phe Glu Lys Leu Asn Leu Pro Val Ile 
    530                 535                 540                 


Lys Lys Thr Lys Thr Gly Tyr Ser Thr Asp Ser Glu Val Leu Glu Gln 
545                 550                 555                 560 


Leu Val Pro Tyr Asn Asn Ile Val Asn Asp Ile Ile Glu Tyr Arg Gln 
                565                 570                 575     


Leu Thr Lys Leu Lys Ser Thr Tyr Ile Asn Gly Phe Leu Pro Leu Met 
            580                 585                 590         


Asp Glu Asn Asn Arg Val His Ser Asn Phe Lys Gln Met Val Thr Ser 
        595                 600                 605             


Thr Gly Arg Ile Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile 
    610                 615                 620                 


Arg Glu Glu Phe Gly Arg Gln Ile Arg Arg Ala Phe Ile Pro Arg Thr 
625                 630                 635                 640 


Lys Asp Gly Tyr Ile Val Ser Ala Asp Tyr Ser Gln Ile Glu Leu Arg 
                645                 650                 655     


Val Leu Ala His Val Ser Gly Asp Glu Lys Leu Ile Glu Ser Phe Met 
            660                 665                 670         


Asn Asn Glu Asp Ile His Leu Arg Thr Ala Ser Glu Val Phe Lys Val 
        675                 680                 685             


Pro Met Glu Lys Val Thr Pro Glu Met Arg Arg Ala Ala Lys Ala Val 
    690                 695                 700                 


Asn Phe Gly Ile Ile Tyr Gly Ile Ser Asp Tyr Gly Leu Ser Arg Asp 
705                 710                 715                 720 


Leu Lys Ile Ser Arg Lys Glu Ala Lys Glu Tyr Ile Asn Asn Tyr Phe 
                725                 730                 735     


Glu Arg Tyr Lys Gly Val Lys Glu Tyr Ile Glu Lys Ile Val Arg Phe 
            740                 745                 750         


Ala Lys Glu Asn Gly Tyr Val Ile Thr Ile Met Asn Arg Arg Arg Tyr 
        755                 760                 765             


Ile Pro Glu Ile Asn Ser Arg Asn Phe Thr Gln Arg Ser Gln Ala Glu 
    770                 775                 780                 


Arg Leu Ala Met Asn Ala Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile 
785                 790                 795                 800 


Lys Met Ala Met Val Arg Val Tyr Asn Asp Leu Glu Lys Leu Lys Leu 
                805                 810                 815     


Lys Ser Lys Leu Ile Leu Gln Val His Asp Glu Leu Val Val Asp Thr 
            820                 825                 830         


Tyr Lys Asp Glu Val Glu Ile Val Lys Lys Ile Leu Lys Asp Asn Met 
        835                 840                 845             


Glu Asn Val Val Gln Leu Lys Val Pro Leu Val Val Glu Ile Gly Val 
    850                 855                 860                 


Gly Pro Asn Trp Phe Leu Ala Lys 
865                 870         


<210>  17
<211>  855
<212>  PRT
<213>  Enterobacteria phage T5

<400>  17

Met Lys Ile Ala Val Val Asp Lys Ala Leu Asn Asn Thr Arg Tyr Asp 
1               5                   10                  15      


Lys His Phe Gln Leu Tyr Gly Glu Glu Val Asp Val Phe His Met Cys 
            20                  25                  30          


Asn Glu Lys Leu Ser Gly Arg Leu Leu Lys Lys His Ile Thr Ile Gly 
        35                  40                  45              


Thr Pro Glu Asn Pro Phe Asp Pro Asn Asp Tyr Asp Phe Val Ile Leu 
    50                  55                  60                  


Val Gly Ala Glu Pro Phe Leu Tyr Phe Ala Gly Lys Lys Gly Ile Gly 
65                  70                  75                  80  


Asp Tyr Thr Gly Lys Arg Val Glu Tyr Asn Gly Tyr Ala Asn Trp Ile 
                85                  90                  95      


Ala Ser Ile Ser Pro Ala Gln Leu His Phe Lys Pro Glu Met Lys Pro 
            100                 105                 110         


Val Phe Asp Ala Thr Val Glu Asn Ile His Asp Ile Ile Asn Gly Arg 
        115                 120                 125             


Glu Lys Ile Ala Lys Ala Gly Asp Tyr Arg Pro Ile Thr Asp Pro Asp 
    130                 135                 140                 


Glu Ala Glu Glu Tyr Ile Lys Met Val Tyr Asn Met Val Ile Gly Pro 
145                 150                 155                 160 


Val Ala Phe Asp Ser Glu Thr Ser Ala Leu Tyr Cys Arg Asp Gly Tyr 
                165                 170                 175     


Leu Leu Gly Val Ser Ile Ser His Gln Glu Tyr Gln Gly Val Tyr Ile 
            180                 185                 190         


Asp Ser Asp Cys Leu Thr Glu Val Ala Val Tyr Tyr Leu Gln Lys Ile 
        195                 200                 205             


Leu Asp Ser Glu Asn His Thr Ile Val Phe His Asn Leu Lys Phe Asp 
    210                 215                 220                 


Met His Phe Tyr Lys Tyr His Leu Gly Leu Thr Phe Asp Lys Ala His 
225                 230                 235                 240 


Lys Glu Arg Arg Leu His Asp Thr Met Leu Gln His Tyr Val Leu Asp 
                245                 250                 255     


Glu Arg Arg Gly Thr His Gly Leu Lys Ser Leu Ala Met Lys Tyr Thr 
            260                 265                 270         


Asp Met Gly Asp Tyr Asp Phe Glu Leu Asp Lys Phe Lys Asp Asp Tyr 
        275                 280                 285             


Cys Lys Ala His Lys Ile Lys Lys Glu Asp Phe Thr Tyr Asp Leu Ile 
    290                 295                 300                 


Pro Phe Asp Ile Met Trp Pro Tyr Ala Ala Lys Asp Thr Asp Ala Thr 
305                 310                 315                 320 


Ile Arg Leu His Asn Phe Phe Leu Pro Lys Ile Glu Lys Asn Glu Lys 
                325                 330                 335     


Leu Cys Ser Leu Tyr Tyr Asp Val Leu Met Pro Gly Cys Val Phe Leu 
            340                 345                 350         


Gln Arg Val Glu Asp Arg Gly Val Pro Ile Ser Ile Asp Arg Leu Lys 
        355                 360                 365             


Glu Ala Gln Tyr Gln Leu Thr His Asn Leu Asn Lys Ala Arg Glu Lys 
    370                 375                 380                 


Leu Tyr Thr Tyr Pro Glu Val Lys Gln Leu Glu Gln Asp Gln Asn Glu 
385                 390                 395                 400 


Ala Phe Asn Pro Asn Ser Val Lys Gln Leu Arg Val Leu Leu Phe Asp 
                405                 410                 415     


Tyr Val Gly Leu Thr Pro Thr Gly Lys Leu Thr Asp Thr Gly Ala Asp 
            420                 425                 430         


Ser Thr Asp Ala Glu Ala Leu Asn Glu Leu Ala Thr Gln His Pro Ile 
        435                 440                 445             


Ala Lys Thr Leu Leu Glu Ile Arg Lys Leu Thr Lys Leu Ile Ser Thr 
    450                 455                 460                 


Tyr Val Glu Lys Ile Leu Leu Ser Ile Asp Ala Asp Gly Cys Ile Arg 
465                 470                 475                 480 


Thr Gly Phe His Glu His Met Thr Thr Ser Gly Arg Leu Ser Ser Ser 
                485                 490                 495     


Gly Lys Leu Asn Leu Gln Gln Leu Pro Arg Asp Glu Ser Ile Ile Lys 
            500                 505                 510         


Gly Cys Val Val Ala Pro Pro Gly Tyr Arg Val Ile Ala Trp Asp Leu 
        515                 520                 525             


Thr Thr Ala Glu Val Tyr Tyr Ala Ala Val Leu Ser Gly Asp Arg Asn 
    530                 535                 540                 


Met Gln Gln Val Phe Ile Asn Met Arg Asn Glu Pro Asp Lys Tyr Pro 
545                 550                 555                 560 


Asp Phe His Ser Asn Ile Ala His Met Val Phe Lys Leu Gln Cys Glu 
                565                 570                 575     


Pro Arg Asp Val Lys Lys Leu Phe Pro Ala Leu Arg Gln Ala Ala Lys 
            580                 585                 590         


Ala Ile Thr Phe Gly Ile Leu Tyr Gly Ser Gly Pro Ala Lys Val Ala 
        595                 600                 605             


His Ser Val Asn Glu Ala Leu Leu Glu Gln Ala Ala Lys Thr Gly Glu 
    610                 615                 620                 


Pro Phe Val Glu Cys Thr Val Ala Asp Ala Lys Glu Tyr Ile Glu Thr 
625                 630                 635                 640 


Tyr Phe Gly Gln Phe Pro Gln Leu Lys Arg Trp Ile Asp Lys Cys His 
                645                 650                 655     


Asp Gln Ile Lys Asn His Gly Phe Ile Tyr Ser His Phe Gly Arg Lys 
            660                 665                 670         


Arg Arg Leu His Asn Ile His Ser Glu Asp Arg Gly Val Gln Gly Glu 
        675                 680                 685             


Glu Ile Arg Ser Gly Phe Asn Ala Ile Ile Gln Ser Ala Ser Ser Asp 
    690                 695                 700                 


Ser Leu Leu Leu Gly Ala Val Asp Ala Asp Asn Glu Ile Ile Ser Leu 
705                 710                 715                 720 


Gly Leu Glu Gln Glu Met Lys Ile Val Met Leu Val His Asp Ser Val 
                725                 730                 735     


Val Ala Ile Val Arg Glu Asp Leu Ile Asp Gln Tyr Asn Glu Ile Leu 
            740                 745                 750         


Ile Arg Asn Ile Gln Lys Asp Arg Gly Ile Ser Ile Pro Gly Cys Pro 
        755                 760                 765             


Ile Gly Ile Asp Ser Asp Ser Glu Ala Gly Gly Ser Arg Asp Tyr Ser 
    770                 775                 780                 


Cys Gly Lys Met Lys Lys Gln His Pro Ser Ile Ala Cys Ile Asp Asp 
785                 790                 795                 800 


Asp Glu Tyr Thr Arg Tyr Val Lys Gly Val Leu Leu Asp Ala Glu Phe 
                805                 810                 815     


Glu Tyr Lys Lys Leu Ala Ala Met Asp Lys Glu His Pro Asp His Ser 
            820                 825                 830         


Lys Tyr Lys Asp Asp Lys Phe Ile Ala Val Cys Lys Asp Leu Asp Asn 
        835                 840                 845             


Val Lys Arg Ile Leu Gly Ala 
    850                 855 


<210>  18
<211>  704
<212>  PRT
<213>  Enterobacteria phage T7

<400>  18

Met Ile Val Ser Asp Ile Glu Ala Asn Ala Leu Leu Glu Ser Val Thr 
1               5                   10                  15      


Lys Phe His Cys Gly Val Ile Tyr Asp Tyr Ser Thr Ala Glu Tyr Val 
            20                  25                  30          


Ser Tyr Arg Pro Ser Asp Phe Gly Ala Tyr Leu Asp Ala Leu Glu Ala 
        35                  40                  45              


Glu Val Ala Arg Gly Gly Leu Ile Val Phe His Asn Gly His Lys Tyr 
    50                  55                  60                  


Asp Val Pro Ala Leu Thr Lys Leu Ala Lys Leu Gln Leu Asn Arg Glu 
65                  70                  75                  80  


Phe His Leu Pro Arg Glu Asn Cys Ile Asp Thr Leu Val Leu Ser Arg 
                85                  90                  95      


Leu Ile His Ser Asn Leu Lys Asp Thr Asp Met Gly Leu Leu Arg Ser 
            100                 105                 110         


Gly Lys Leu Pro Gly Lys Arg Phe Gly Ser His Ala Leu Glu Ala Trp 
        115                 120                 125             


Gly Tyr Arg Leu Gly Glu Met Lys Gly Glu Tyr Lys Asp Asp Phe Lys 
    130                 135                 140                 


Arg Met Leu Glu Glu Gln Gly Glu Glu Tyr Val Asp Gly Met Glu Trp 
145                 150                 155                 160 


Trp Asn Phe Asn Glu Glu Met Met Asp Tyr Asn Val Gln Asp Val Val 
                165                 170                 175     


Val Thr Lys Ala Leu Leu Glu Lys Leu Leu Ser Asp Lys His Tyr Phe 
            180                 185                 190         


Pro Pro Glu Ile Asp Phe Thr Asp Val Gly Tyr Thr Thr Phe Trp Ser 
        195                 200                 205             


Glu Ser Leu Glu Ala Val Asp Ile Glu His Arg Ala Ala Trp Leu Leu 
    210                 215                 220                 


Ala Lys Gln Glu Arg Asn Gly Phe Pro Phe Asp Thr Lys Ala Ile Glu 
225                 230                 235                 240 


Glu Leu Tyr Val Glu Leu Ala Ala Arg Arg Ser Glu Leu Leu Arg Lys 
                245                 250                 255     


Leu Thr Glu Thr Phe Gly Ser Trp Tyr Gln Pro Lys Gly Gly Thr Glu 
            260                 265                 270         


Met Phe Cys His Pro Arg Thr Gly Lys Pro Leu Pro Lys Tyr Pro Arg 
        275                 280                 285             


Ile Lys Thr Pro Lys Val Gly Gly Ile Phe Lys Lys Pro Lys Asn Lys 
    290                 295                 300                 


Ala Gln Arg Glu Gly Arg Glu Pro Cys Glu Leu Asp Thr Arg Glu Tyr 
305                 310                 315                 320 


Val Ala Gly Ala Pro Tyr Thr Pro Val Glu His Val Val Phe Asn Pro 
                325                 330                 335     


Ser Ser Arg Asp His Ile Gln Lys Lys Leu Gln Glu Ala Gly Trp Val 
            340                 345                 350         


Pro Thr Lys Tyr Thr Asp Lys Gly Ala Pro Val Val Asp Asp Glu Val 
        355                 360                 365             


Leu Glu Gly Val Arg Val Asp Asp Pro Glu Lys Gln Ala Ala Ile Asp 
    370                 375                 380                 


Leu Ile Lys Glu Tyr Leu Met Ile Gln Lys Arg Ile Gly Gln Ser Ala 
385                 390                 395                 400 


Glu Gly Asp Lys Ala Trp Leu Arg Tyr Val Ala Glu Asp Gly Lys Ile 
                405                 410                 415     


His Gly Ser Val Asn Pro Asn Gly Ala Val Thr Gly Arg Ala Thr His 
            420                 425                 430         


Ala Phe Pro Asn Leu Ala Gln Ile Pro Gly Val Arg Ser Pro Tyr Gly 
        435                 440                 445             


Glu Gln Cys Arg Ala Ala Phe Gly Ala Glu His His Leu Asp Gly Ile 
    450                 455                 460                 


Thr Gly Lys Pro Trp Val Gln Ala Gly Ile Asp Ala Ser Gly Leu Glu 
465                 470                 475                 480 


Leu Arg Cys Leu Ala His Phe Met Ala Arg Phe Asp Asn Gly Glu Tyr 
                485                 490                 495     


Ala His Glu Ile Leu Asn Gly Asp Ile His Thr Lys Asn Gln Ile Ala 
            500                 505                 510         


Ala Glu Leu Pro Thr Arg Asp Asn Ala Lys Thr Phe Ile Tyr Gly Phe 
        515                 520                 525             


Leu Tyr Gly Ala Gly Asp Glu Lys Ile Gly Gln Ile Val Gly Ala Gly 
    530                 535                 540                 


Lys Glu Arg Gly Lys Glu Leu Lys Lys Lys Phe Leu Glu Asn Thr Pro 
545                 550                 555                 560 


Ala Ile Ala Ala Leu Arg Glu Ser Ile Gln Gln Thr Leu Val Glu Ser 
                565                 570                 575     


Ser Gln Trp Val Ala Gly Glu Gln Gln Val Lys Trp Lys Arg Arg Trp 
            580                 585                 590         


Ile Lys Gly Leu Asp Gly Arg Lys Val His Val Arg Ser Pro His Ala 
        595                 600                 605             


Ala Leu Asn Thr Leu Leu Gln Ser Ala Gly Ala Leu Ile Cys Lys Leu 
    610                 615                 620                 


Trp Ile Ile Lys Thr Glu Glu Met Leu Val Glu Lys Gly Leu Lys His 
625                 630                 635                 640 


Gly Trp Asp Gly Asp Phe Ala Tyr Met Ala Trp Val His Asp Glu Ile 
                645                 650                 655     


Gln Val Gly Cys Arg Thr Glu Glu Ile Ala Gln Val Val Ile Glu Thr 
            660                 665                 670         


Ala Gln Glu Ala Met Arg Trp Val Gly Asp His Trp Asn Phe Arg Cys 
        675                 680                 685             


Leu Leu Asp Thr Glu Gly Lys Met Gly Pro Asn Trp Ala Ile Cys His 
    690                 695                 700                 


<210>  19
<211>  1090
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is M

<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is Q

<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa is W

<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (9)..(9)
<223>  Xaa is M or L

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is R, E, T or F

<220>
<221>  Xaa
<222>  (11)..(11)
<223>  Xaa is G, A, P, Q or M

<220>
<221>  Xaa
<222>  (12)..(12)
<223>  Xaa is M, L, E or N

<220>
<221>  Xaa
<222>  (13)..(13)
<223>  Xaa is L, F, N or S

<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is P, D, T, N or M

<220>
<221>  Xaa
<222>  (15)..(15)
<223>  Xaa is L, E, D or V

<220>
<221>  Xaa
<222>  (16)..(16)
<223>  Xaa is F, E, K, Y or Q

<220>
<221>  Xaa
<222>  (17)..(17)
<223>  Xaa is E, Q or I

<220>
<221>  Xaa
<222>  (18)..(18)
<223>  Xaa is P, S or A

<220>
<221>  Xaa
<222>  (19)..(19)
<223>  Xaa is K, P, M, N or Q

<220>
<221>  Xaa
<222>  (20)..(20)
<223>  Xaa is G, K, H, R, D, N, A, Y or S

<220>
<221>  Xaa
<222>  (21)..(21)
<223>  Xaa is  R, E, K or P

<220>
<221>  Xaa
<222>  (22)..(22)
<223>  Xaa is  V, I, F or L

<220>
<221>  Xaa
<222>  (23)..(23)
<223>  Xaa is  L, Y, V, I or F

<220>
<221>  Xaa
<222>  (24)..(24)
<223>  Xaa is  L

<220>
<221>  Xaa
<222>  (25)..(25)
<223>  Xaa is V, I or F

<220>
<221>  Xaa
<222>  (26)..(26)
<223>  Xaa is  D

<220>
<221>  Xaa
<222>  (27)..(27)
<223>  Xaa is  G

<220>
<221>  Xaa
<222>  (28)..(28)
<223>  Xaa is  H, S, N or T

<220>
<221>  Xaa
<222>  (29)..(29)
<223>  Xaa is  H, C, S, G or A

<220>
<221>  Xaa
<222>  (30)..(30)
<223>  Xaa is  L

<220>
<221>  Xaa
<222>  (31)..(31)
<223>  Xaa is A, I, L, V or M

<220>
<221>  Xaa
<222>  (32)..(32)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (33)..(33)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (34)..(34)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (35)..(35)
<223>  Xaa is F or Y

<220>
<221>  Xaa
<222>  (36)..(36)
<223>  Xaa is H, F or Y

<220>
<221>  Xaa
<222>  (37)..(37)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (38)..(38)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (39)..(39)
<223>  Xaa is K, S, P or D

<220>
<221>  Xaa
<222>  (40)..(40)
<223>  Xaa is Q or R

<220>
<221>  Xaa
<222>  (41)..(41)
<223>  Xaa is G, P, L, S, F or M

<220>
<221>  Xaa
<222>  (42)..(42)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (43)..(43)
<223>  Xaa is K, T, S, Q or H

<220>
<221>  Xaa
<222>  (44)..(44)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (45)..(45)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (46)..(46)
<223>  Xaa is R, N, Q, A, S, T, K or E

<220>
<221>  Xaa
<222>  (47)..(47)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (48)..(48)
<223>  Xaa is E, I, F, M or L

<220>
<221>  Xaa
<222>  (49)..(49)
<223>  Xaa is P, L, F or H

<220>
<221>  Xaa
<222>  (50)..(50)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (51)..(51)
<223>  Xaa is N

<220>
<221>  Xaa
<222>  (52)..(52)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (53)..(53)
<223>  Xaa is V, I, L, M or T

<220>
<221>  Xaa
<222>  (54)..(54)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (55)..(55)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (56)..(56)
<223>  Xaa is F

<220>
<221>  Xaa
<222>  (57)..(57)
<223>  Xaa is A, T, I or L

<220>
<221>  Xaa
<222>  (58)..(58)
<223>  Xaa is K, R, T, N or M

<220>
<221>  Xaa
<222>  (59)..(59)
<223>  Xaa is M

<220>
<221>  Xaa
<222>  (60)..(60)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (61)..(61)
<223>  Xaa is V, I, N, R or L

<220>
<221>  Xaa
<222>  (62)..(62)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (63)..(63)
<223>  Xaa is A, L, F or I

<220>
<221>  Xaa
<222>  (64)..(64)
<223>  Xaa is L, V or I

<220>
<221>  Xaa
<222>  (65)..(65)
<223>  Xaa is K, R, E, Q, M or A

<220>
<221>  Xaa
<222>  (66)..(66)
<223>  Xaa is E, D or Q

<220>
<221>  Xaa
<222>  (67)..(67)
<223>  Xaa is D, K, F, E, Y or H

<220>
<221>  Xaa
<222>  (68)..(68)
<223>  Xaa is V or I

<220>
<221>  Xaa
<222>  (69)..(69)
<223>  Xaa is K, N or I

<220>
<221>  Xaa
<222>  (70)..(70)
<223>  Xaa is V, M or I

<220>
<221>  Xaa
<222>  (71)..(71)
<223>  Xaa is G, N, S, K, E or R

<220>
<221>  Xaa
<222>  (72)..(72)
<223>  Xaa is Y, V, P or K

<220>
<221>  Xaa
<222>  (73)..(73)
<223>  Xaa is D, Q, N, T or K

<220>
<221>  Xaa
<222>  (74)..(74)
<223>  Xaa is A, Y, L or H

<220>
<221>  Xaa
<222>  (75)..(75)
<223>  Xaa is V, I, L, A, T, C or M

<220>
<221>  Xaa
<222>  (76)..(76)
<223>  Xaa is I, F, V, L, G or A

<220>
<221>  Xaa
<222>  (77)..(77)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (78)..(78)
<223>  Xaa is A, V or I

<220>
<221>  Xaa
<222>  (79)..(79)
<223>  Xaa is F

<220>
<221>  Xaa
<222>  (80)..(80)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (81)..(81)
<223>  Xaa is A, S, R, T or K

<220>
<221>  Xaa
<222>  (82)..(82)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (83)..(83)
<223>  Xaa is A, H, E, G, T or K

<220>
<221>  Xaa
<222>  (84)..(84)
<223>  Xaa is P, A, R, G, T or K

<220>
<221>  Xaa
<222>  (85)..(85)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (86)..(86)
<223>  Xaa is F

<220>
<221>  Xaa
<222>  (87)..(87)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (88)..(88)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (89)..(89)
<223>  Xaa is H

<220>
<221>  Xaa
<222>  (90)..(90)
<223>  Xaa is E, K, V or H

<220>
<221>  Xaa
<222>  (91)..(91)
<223>  Xaa is E, A, I, K, T or L

<220>
<221>  Xaa
<222>  (92)..(92)
<223>  Xaa is Y, F or L

<220>
<221>  Xaa
<222>  (93)..(93)
<223>  Xaa is G, E, K, P or Q

<220>
<221>  Xaa
<222>  (94)..(94)
<223>  Xaa is G, E, A, H, T or D

<220>
<221>  Xaa
<222>  (95)..(95)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (96)..(96)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (97)..(97)
<223>  Xaa is A, I, G or S

<220>
<221>  Xaa
<222>  (98)..(98)
<223>  Xaa is G, T, Q, H, K or N

<220>
<221>  Xaa
<222>  (99)..(99)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (100)..(100)
<223>  Xaa is A, P, D or Q

<220>
<221>  Xaa
<222>  (101)..(101)
<223>  Xaa is P, E, K, A or Q

<220>
<221>  Xaa
<222>  (102)..(102)
<223>  Xaa is T, M or A

<220>
<221>  Xaa
<222>  (103)..(103)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (104)..(104)
<223>  Xaa is P, E, K or D

<220>
<221>  Xaa
<222>  (105)..(105)
<223>  Xaa is A, E, L or D

<220>
<221>  Xaa
<222>  (106)..(106)
<223>  Xaa is F, M, L or I

<220>
<221>  Xaa
<222>  (107)..(107)
<223>  Xaa is P, K, R, I, L, S or A

<220>
<221>  Xaa
<222>  (108)..(108)
<223>  Xaa is R, V, A, P, Q or E

<220>
<221>  Xaa
<222>  (109)..(109)
<223>  Xaa is Q

<220>
<221>  Xaa
<222>  (110)..(110)
<223>  Xaa is L, I, M, F or V

<220>
<221>  Xaa
<222>  (111)..(111)
<223>  Xaa is A, D, P or E

<220>
<221>  Xaa
<222>  (112)..(112)
<223>  Xaa is L, Y, W, M or P

<220>
<221>  Xaa
<222>  (113)..(113)
<223>  Xaa is I, V or L

<220>
<221>  Xaa
<222>  (114)..(114)
<223>  Xaa is K, R, H or E

<220>
<221>  Xaa
<222>  (115)..(115)
<223>  Xaa is E, R, Q, A or K

<220>
<221>  Xaa
<222>  (116)..(116)
<223>  Xaa is L, I, F, M or G

<220>
<221>  Xaa
<222>  (117)..(117)
<223>  Xaa is V, I or L

<220>
<221>  Xaa
<222>  (118)..(118)
<223>  Xaa is D, R, E, K, Q or N

<220>
<221>  Xaa
<222>  (119)..(119)
<223>  Xaa is L, A or G

<220>
<221>  Xaa
<222>  (120)..(120)
<223>  Xaa is L, N, M, F or Y

<220>
<221>  Xaa
<222>  (121)..(121)
<223>  Xaa is G, D, N or R

<220>
<221>  Xaa
<222>  (122)..(122)
<223>  Xaa is L, F, I, M or V

<220>
<221>  Xaa
<222>  (123)..(123)
<223>  Xaa is A, T, V, P, N or K

<220>
<221>  Xaa
<222>  (124)..(124)
<223>  Xaa is R, L, Y, V, A, T or I

<220>
<221>  Xaa
<222>  (125)..(125)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (126)..(126)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (127)..(127)
<223>  Xaa is V, A, E, K, Y, I or L

<220>
<221>  Xaa
<222>  (128)..(128)
<223>  Xaa is P, D, S, E or L

<220>
<221>  Xaa
<222>  (129)..(129)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (130)..(130)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (131)..(131)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (132)..(132)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (133)..(133)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (134)..(134)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (135)..(135)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (136)..(136)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (137)..(137)
<223>  Xaa is A, G or V

<220>
<221>  Xaa
<222>  (138)..(138)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (139)..(139)
<223>  Xaa is L, A, F, I or D

<220>
<221>  Xaa
<222>  (140)..(140)
<223>  Xaa is A, V, T, S or K

<220>
<221>  Xaa
<222>  (141)..(141)
<223>  Xaa is K, G, R, V or A

<220>
<221>  Xaa
<222>  (142)..(142)
<223>  Xaa is K, N, V, I, E, M, R or L

<220>
<221>  Xaa
<222>  (143)..(143)
<223>  Xaa is A, P, I, V, G, F or N

<220>
<221>  Xaa
<222>  (144)..(144)
<223>  Xaa is E, N, K, L or C

<220>
<221>  Xaa
<222>  (145)..(145)
<223>  Xaa is K, R, Q, S, P, N, E or T

<220>
<221>  Xaa
<222>  (146)..(146)
<223>  Xaa is E, F, Y, A, L, K or R

<220>
<221>  Xaa
<222>  (147)..(147)
<223>  Xaa is G, A, K, D, F or Y

<220>
<221>  Xaa
<222>  (148)..(148)
<223>  Xaa is Y, M, P, D, K, R, E or F

<220>
<221>  Xaa
<222>  (149)..(149)
<223>  Xaa is E, L, D, P or K

<220>
<221>  Xaa
<222>  (150)..(150)
<223>  Xaa is V, N, L, T, I or H

<220>
<221>  Xaa
<222>  (151)..(151)
<223>  Xaa is R, F, K, M or L

<220>
<221>  Xaa
<222>  (152)..(152)
<223>  Xaa is I, Y or Q

<220>
<221>  Xaa
<222>  (153)..(153)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (154)..(154)
<223>  Xaa is L, I, V, S or Y

<220>
<221>  Xaa
<222>  (155)..(155)
<223>  Xaa is T, S or G

<220>
<221>  Xaa
<222>  (156)..(156)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (157)..(157)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (158)..(158)
<223>  Xaa is K, R, L or V

<220>
<221>  Xaa
<222>  (159)..(159)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (160)..(160)
<223>  Xaa is L, F, M, A or V

<220>
<221>  Xaa
<222>  (161)..(161)
<223>  Xaa is Y, D, F, L, R or T

<220>
<221>  Xaa
<222>  (162)..(162)
<223>  Xaa is Q

<220>
<221>  Xaa
<222>  (163)..(163)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (164)..(164)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (165)..(165)
<223>  Xaa is S, D, T or N

<220>
<221>  Xaa
<222>  (166)..(166)
<223>  Xaa is D, E or P

<220>
<221>  Xaa
<222>  (167)..(167)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (168)..(168)
<223>  Xaa is I, V, T or L

<220>
<221>  Xaa
<222>  (169)..(169)
<223>  Xaa is H, A, S, K, F, T or Y

<220>
<221>  Xaa
<222>  (170)..(170)
<223>  Xaa is V, I , L or G

<220>
<221>  Xaa
<222>  (171)..(171)
<223>  Xaa is L, Y, I , W, D, K or R

<220>
<221>  Xaa
<222>  (172)..(172)
<223>  Xaa is H, L, D, N, R or I

<220>
<221>  Xaa
<222>  (173)..(173)
<223>  Xaa is P, T, I, S or L

<220>
<221>  Xaa
<222>  (174)..(174)
<223>  Xaa is E, D, I, Q, K, M, S or V

<220>
<221>  Xaa
<222>  (175)..(175)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (176)..(176)
<223>  Xaa is Y, H, T, E, G or N

<220>
<221>  Xaa
<222>  (177)..(177)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (178)..(178)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (179)..(179)
<223>  Xaa is E, Q or D

<220>
<221>  Xaa
<222>  (180)..(180)
<223>  Xaa is F, M, L or I

<220>
<221>  Xaa
<222>  (181)..(181)
<223>  Xaa is T or E

<220>
<221>  Xaa
<222>  (182)..(182)
<223>  Xaa is I, S, F, L, P or E

<220>
<221>  Xaa
<222>  (183)..(183)
<223>  Xaa is I, V, Y, L or F

<220>
<221>  Xaa
<222>  (184)..(184)
<223>  Xaa is T, D or G

<220>
<221>  Xaa
<222>  (185)..(185)
<223>  Xaa is P, R, G, K, A or E

<220>
<221>  Xaa
<222>  (186)..(186)
<223>  Xaa is A, E, K or Q

<220>
<221>  Xaa
<222>  (187)..(187)
<223>  Xaa is W, D, Y, A, K, E, T or I

<220>
<221>  Xaa
<222>  (188)..(188)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (189)..(189)
<223>  Xaa is W, Q, I, K, V, E, R, L or T

<220>
<221>  Xaa
<222>  (190)..(190)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (191)..(191)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (192)..(192)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (193)..(193)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (194)..(194)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (195)..(195)
<223>  Xaa is R, K, P, E, N, F, T or D

<220>
<221>  Xaa
<222>  (196)..(196)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (197)..(197)
<223>  Xaa is D, E, Y, S, H, Q or N

<220>
<221>  Xaa
<222>  (198)..(198)
<223>  Xaa is Q, R, K, L or D

<220>
<221>  Xaa
<222>  (199)..(199)
<223>  Xaa is W, L, I, F, M or Y

<220>
<221>  Xaa
<222>  (200)..(200)
<223>  Xaa is A, V, N, P, I, G or D

<220>
<221>  Xaa
<222>  (201)..(201)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (202)..(202)
<223>  Xaa is Y, F, L or V

<220>
<221>  Xaa
<222>  (203)..(203)
<223>  Xaa is R, M, K, L or I

<220>
<221>  Xaa
<222>  (204)..(204)
<223>  Xaa is A, V, S, G, L or M

<220>
<221>  Xaa
<222>  (205)..(205)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (206)..(206)
<223>  Xaa is T, V, M or G

<220>
<221>  Xaa
<222>  (207)..(207)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (208)..(208)
<223>  Xaa is D or E

<220>
<221>  Xaa
<222>  (209)..(209)
<223>  Xaa is E, P, R, A, K, S, Q or I

<220>
<221>  Xaa
<222>  (210)..(210)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (211)..(211)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (212)..(212)
<223>  Xaa is N

<220>
<221>  Xaa
<222>  (213)..(213)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (214)..(214)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (215)..(215)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (216)..(216)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (217)..(217)
<223>  Xaa is K, A, N, P, T or L

<220>
<221>  Xaa
<222>  (218)..(218)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (219)..(219)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (220)..(220)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (221)..(221)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (222)..(222)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (223)..(223)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (224)..(224)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (225)..(225)
<223>  Xaa is R, L, A, S, Q, V, I, K or C

<220>
<221>  Xaa
<222>  (226)..(226)
<223>  Xaa is K, R, N, E, Q, S or G

<220>
<221>  Xaa
<222>  (227)..(227)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (228)..(228)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (229)..(229)
<223>  Xaa is E, K, A, N, Q, R or Y

<220>
<221>  Xaa
<222>  (230)..(230)
<223>  Xaa is E, R, K, N, G, Q or D

<220>
<221>  Xaa
<222>  (231)..(231)
<223>  Xaa is W, Y, I, L or F

<220>
<221>  Xaa
<222>  (232)..(232)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (233)..(233)
<223>  Xaa is S, D, G, N or T

<220>
<221>  Xaa
<222>  (234)..(234)
<223>  Xaa is L, V, I, Y or A

<220>
<221>  Xaa
<222>  (235)..(235)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (236)..(236)
<223>  Xaa is A, N, E, K, T, D or Y

<220>
<221>  Xaa
<222>  (237)..(237)
<223>  Xaa is L, I, F, V or W

<220>
<221>  Xaa
<222>  (238)..(238)
<223>  Xaa is L, K, Y, I or S

<220>
<221>  Xaa
<222>  (239)..(239)
<223>  Xaa is K, S, A, G, N, Q or Y

<220>
<221>  Xaa
<222>  (240)..(240)
<223>  Xaa is N, K, S, E, H or R

<220>
<221>  Xaa
<222>  (241)..(241)
<223>  Xaa is L, I , P, V or K

<220>
<221>  Xaa
<222>  (242)..(242)
<223>  Xaa is D, K, E, H, R or S

<220>
<221>  Xaa
<222>  (243)..(243)
<223>  Xaa is R, I, V, G, K, E, L, Q or D

<220>
<221>  Xaa
<222>  (244)..(244)
<223>  Xaa is L, V, I or F

<220>
<221>  Xaa
<222>  (245)..(245)
<223>  Xaa is K, D, G, A, N, P or T

<220>
<221>  Xaa
<222>  (246)..(246)
<223>  Xaa is P, S, G, Q, E or A

<220>
<221>  Xaa
<222>  (247)..(247)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (248)..(248)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (249)..(249)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (250)..(250)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (251)..(251)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (252)..(252)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (253)..(253)
<223>  Xaa is A, E, D, L or K

<220>
<221>  Xaa
<222>  (254)..(254)
<223>  Xaa is N, S, K, D, T or R

<220>
<221>  Xaa
<222>  (255)..(255)
<223>  Xaa is I, V, L, M, T or Y

<220>
<221>  Xaa
<222>  (256)..(256)
<223>  Xaa is R, S, Q, A, G, K, P or L

<220>
<221>  Xaa
<222>  (257)..(257)
<223>  Xaa is E, R, D, S, A or K

<220>
<221>  Xaa
<222>  (258)..(258)
<223>  Xaa is K, I, L, T, A, N or Q

<220>
<221>  Xaa
<222>  (259)..(259)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (260)..(260)
<223>  Xaa is L, K, E, A, S, R or H

<220>
<221>  Xaa
<222>  (261)..(261)
<223>  Xaa is A, K, D, Q, R, N or F

<220>
<221>  Xaa
<222>  (262)..(262)
<223>  Xaa is H, N, G, D, A, Y, K or E

<220>
<221>  Xaa
<222>  (263)..(263)
<223>  Xaa is M, L, I, W, K, R, T, P or V

<220>
<221>  Xaa
<222>  (264)..(264)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (265)..(265)
<223>  Xaa is D, S, I, K, V, N, L, M or R

<220>
<221>  Xaa
<222>  (266)..(266)
<223>  Xaa is L, I, A, K or G

<220>
<221>  Xaa
<222>  (267)..(267)
<223>  Xaa is K, R, H, Q, E, F, Y, I, L, P or G

<220>
<221>  Xaa
<222>  (268)..(268)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (269)..(269)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (270)..(270)
<223>  Xaa is W, L, K, Y, R, D or V

<220>
<221>  Xaa
<222>  (271)..(271)
<223>  Xaa is D, E, Q, K, R, A or F

<220>
<221>  Xaa
<222>  (272)..(272)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (273)..(273)
<223>  Xaa is A, S, V or N

<220>
<221>  Xaa
<222>  (274)..(274)
<223>  Xaa is K, R, I, T, Q, A, E or G

<220>
<221>  Xaa
<222>  (275)..(275)
<223>  Xaa is V, I , L, N or H

<220>
<221>  Xaa
<222>  (276)..(276)
<223>  Xaa is R, D, K, M, E or I

<220>
<221>  Xaa
<222>  (277)..(277)
<223>  Xaa is T, K, C, Y, R or H

<220>
<221>  Xaa
<222>  (278)..(278)
<223>  Xaa is D, N or E

<220>
<221>  Xaa
<222>  (279)..(279)
<223>  Xaa is L, T, I, E, V or A

<220>
<221>  Xaa
<222>  (280)..(280)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (281)..(281)
<223>  Xaa is L, I, K, V, N or A

<220>
<221>  Xaa
<222>  (282)..(282)
<223>  Xaa is I or G

<220>
<221>  Xaa
<222>  (283)..(283)
<223>  Xaa is E or R

<220>
<221>  Xaa
<222>  (284)..(284)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (285)..(285)
<223>  Xaa is V, I, L, K or T

<220>
<221>  Xaa
<222>  (286)..(286)
<223>  Xaa is D, K, I, T, N or S

<220>
<221>  Xaa
<222>  (287)..(287)
<223>  Xaa is F, L, W, C, I or A

<220>
<221>  Xaa
<222>  (288)..(288)
<223>  Xaa is A, K, D, N or E

<220>
<221>  Xaa
<222>  (289)..(289)
<223>  Xaa is A, D, P, Q or K

<220>
<221>  Xaa
<222>  (290)..(290)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (291)..(291)
<223>  Xaa is K, Q, R, E, I, A or D

<220>
<221>  Xaa
<222>  (292)..(292)
<223>  Xaa is R, G, I, K, V, Y or L

<220>
<221>  Xaa
<222>  (293)..(293)
<223>  Xaa is R, K, F, Q, A, E or N

<220>
<221>  Xaa
<222>  (294)..(294)
<223>  Xaa is E, T, Q, R, G, K, D or P

<220>
<221>  Xaa
<222>  (295)..(295)
<223>  Xaa is P, Q, D, I, Y, H, E or F

<220>
<221>  Xaa
<222>  (296)..(296)
<223>  Xaa is D, A, K, N, T or F

<220>
<221>  Xaa
<222>  (297)..(297)
<223>  Xaa is R, L, S, A, E, D or H

<220>
<221>  Xaa
<222>  (298)..(298)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (299)..(299)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (300)..(300)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (301)..(301)
<223>  Xaa is R, V, I , L, A or E

<220>
<221>  Xaa
<222>  (302)..(302)
<223>  Xaa is A, Q, D, E, G, S, P, V or N

<220>
<221>  Xaa
<222>  (303)..(303)
<223>  Xaa is F, I, L, V, E or C

<220>
<221>  Xaa
<222>  (304)..(304)
<223>  Xaa is L, F, Y or I

<220>
<221>  Xaa
<222>  (305)..(305)
<223>  Xaa is E, R, K, Q, N, I or D

<220>
<221>  Xaa
<222>  (306)..(306)
<223>  Xaa is R, E, K or T

<220>
<221>  Xaa
<222>  (307)..(307)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (308)..(308)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (309)..(309)
<223>  Xaa is F

<220>
<221>  Xaa
<222>  (310)..(310)
<223>  Xaa is G, N, K, S, A, Q or F

<220>
<221>  Xaa
<222>  (311)..(311)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (312)..(312)
<223>  Xaa is L, I, W, F or V

<220>
<221>  Xaa
<222>  (313)..(313)
<223>  Xaa is L,T, M or I

<220>
<221>  Xaa
<222>  (314)..(314)
<223>  Xaa is H, K, Q, E, A, D or G

<220>
<221>  Xaa
<222>  (315)..(315)
<223>  Xaa is E, Q, K, R, D, N, S or P

<220>
<221>  Xaa
<222>  (316)..(316)
<223>  Xaa is F, I, L, V, M or N

<220>
<221>  Xaa
<222>  (317)..(317)
<223>  Xaa is I, F, P, E, G, Q, D, K , A or L

<220>
<221>  Xaa
<222>  (318)..(318)
<223>  Xaa is K, P, A, L or F

<220>
<221>  Xaa
<222>  (319)..(319)
<223>  Xaa is D, S, G or Y

<220>
<221>  Xaa
<222>  (320)..(320)
<223>  Xaa is F, L, D, K, T or S

<220>
<221>  Xaa
<222>  (321)..(321)
<223>  Xaa is P, Q, E, W, K, A, S or D

<220>
<221>  Xaa
<222>  (322)..(322)
<223>  Xaa is N, E, L, Q, P, K, T or M

<220>
<221>  Xaa
<222>  (323)..(323)
<223>  Xaa is G, H, E, Q, D, S, T or N

<220>
<221>  Xaa
<222>  (324)..(324)
<223>  Xaa is L, S, E, K, A, Q or N

<220>
<221>  Xaa
<222>  (325)..(325)
<223>  Xaa is L, S, N, K, P, E or V

<220>
<221>  Xaa
<222>  (326)..(326)
<223>  Xaa is E, G, C, I, D, T, V, K or R

<220>
<221>  Xaa
<222>  (327)..(327)
<223>  Xaa is S, A, G, E, Q, P, K or I

<220>
<221>  Xaa
<222>  (328)..(328)
<223>  Xaa is S, K, Y, T, V or G

<220>
<221>  Xaa
<222>  (329)..(329)
<223>  Xaa is P, I, R, T, D, N or K

<220>
<221>  Xaa
<222>  (330)..(330)
<223>  Xaa is V, A, I , L or N

<220>
<221>  Xaa
<222>  (331)..(331)
<223>  Xaa is N, A, V, M, H or P

<220>
<221>  Xaa
<222>  (332)..(332)
<223>  Xaa is E, K, N or G

<220>
<221>  Xaa
<222>  (333)..(333)
<223>  Xaa is G, P or K

<220>
<221>  Xaa
<222>  (334)..(334)
<223>  Xaa is K, Q or R

<220>
<221>  Xaa
<222>  (335)..(335)
<223>  Xaa is Tor E

<220>
<221>  Xaa
<222>  (336)..(336)
<223>  Xaa is SorT

<220>
<221>  Xaa
<222>  (337)..(337)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (338)..(338)
<223>  Xaa is F or V

<220>
<221>  Xaa
<222>  (339)..(339)
<223>  Xaa is N or A

<220>
<221>  Xaa
<222>  (340)..(340)
<223>  Xaa is W or D

<220>
<221>  Xaa
<222>  (341)..(341)
<223>  Xaa is D or E

<220>
<221>  Xaa
<222>  (342)..(342)
<223>  Xaa is N or A

<220>
<221>  Xaa
<222>  (343)..(343)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (344)..(344)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (345)..(345)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (346)..(346)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (347)..(347)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (348)..(348)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (349)..(349)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (350)..(350)
<223>  Xaa is F or I

<220>
<221>  Xaa
<222>  (351)..(351)
<223>  Xaa is S or Y

<220>
<221>  Xaa
<222>  (352)..(352)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (353)..(353)
<223>  Xaa is I or D

<220>
<221>  Xaa
<222>  (354)..(354)
<223>  Xaa is S or N

<220>
<221>  Xaa
<222>  (355)..(355)
<223>  Xaa is E or Y

<220>
<221>  Xaa
<222>  (356)..(356)
<223>  Xaa is F or V

<220>
<221>  Xaa
<222>  (357)..(357)
<223>  Xaa is P or T

<220>
<221>  Xaa
<222>  (358)..(358)
<223>  Xaa is H or I

<220>
<221>  Xaa
<222>  (359)..(359)
<223>  Xaa is E, L or F

<220>
<221>  Xaa
<222>  (360)..(360)
<223>  Xaa is N, D, S, M, V or G

<220>
<221>  Xaa
<222>  (361)..(361)
<223>  Xaa is P, E, V, I, S, N, L, A or Q

<220>
<221>  Xaa
<222>  (362)..(362)
<223>  Xaa is K, A, L, D, E, N, V, F, Y or H

<220>
<221>  Xaa
<222>  (363)..(363)
<223>  Xaa is A, P, Q, D, N, T, S, E, V, W, C or A

<220>
<221>  Xaa
<222>  (364)..(364)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (365)..(365)
<223>  Xaa is E, N , K, S, A or D

<220>
<221>  Xaa
<222>  (366)..(366)
<223>  Xaa is E, L, S, A, K, D, V or G

<220>
<221>  Xaa
<222>  (367)..(367)
<223>  Xaa is A, I, E, W, L, G, R, D or Y

<220>
<221>  Xaa
<222>  (368)..(368)
<223>  Xaa is P, S, N, L, I, F, V, R or G

<220>
<221>  Xaa
<222>  (369)..(369)
<223>  Xaa is W, E, F, A, K, T, L or Y

<220>
<221>  Xaa
<222>  (370)..(370)
<223>  Xaa is P, N, K , R, D, E or G

<220>
<221>  Xaa
<222>  (371)..(371)
<223>  Xaa is P, R, E, F, L, I or V

<220>
<221>  Xaa
<222>  (372)..(372)
<223>  Xaa is P, R, V, I, E, K, R, D, M, S or G

<220>
<221>  Xaa
<222>  (373)..(373)
<223>  Xaa is E, N, Q, K, L, T or I

<220>
<221>  Xaa
<222>  (374)..(374)
<223>  Xaa is G, T, K, D, A, S, V, L or M

<220>
<221>  Xaa
<222>  (375)..(375)
<223>  Xaa is I, G, P, Q, K, D, L or H

<220>
<221>  Xaa
<222>  (376)..(376)
<223>  Xaa is E, N, V, Y, S, T, K, Q or G

<220>
<221>  Xaa
<222>  (377)..(377)
<223>  Xaa is A, L , G, H, F, D or E

<220>
<221>  Xaa
<222>  (378)..(378)
<223>  Xaa is F, I , Y, K, A, V, S or N

<220>
<221>  Xaa
<222>  (379)..(379)
<223>  Xaa is V, E, F, M, L, I, R, K or Q

<220>
<221>  Xaa
<222>  (380)..(380)
<223>  Xaa is G, K, A, D, V, N or S

<220>
<221>  Xaa
<222>  (381)..(381)
<223>  Xaa is F, I , L, T, V or D

<220>
<221>  Xaa
<222>  (382)..(382)
<223>  Xaa is V, L, K, Y, E, A or F

<220>
<221>  Xaa
<222>  (383)..(383)
<223>  Xaa is L, E, C, R, T, V, F, I or K

<220>
<221>  Xaa
<222>  (384)..(384)
<223>  Xaa is S, Y , L, H, T, M, V or R

<220>
<221>  Xaa
<222>  (385)..(385)
<223>  Xaa is R, G, L, S, E, P or M

<220>
<221>  Xaa
<222>  (386)..(386)
<223>  Xaa is K, P, D, L or E

<220>
<221>  Xaa
<222>  (387)..(387)
<223>  Xaa is E, F, R, K, D, S, N, I or C

<220>
<221>  Xaa
<222>  (388)..(388)
<223>  Xaa is P, S, A, K, N, Y, L or E

<220>
<221>  Xaa
<222>  (389)..(389)
<223>  Xaa is M, V, F, L, I, H, T or G

<220>
<221>  Xaa
<222>  (390)..(390)
<223>  Xaa is W, T, E, S, D or G

<220>
<221>  Xaa
<222>  (391)..(391)
<223>  Xaa is A, F, G, T, C, V or E

<220>
<221>  Xaa
<222>  (392)..(392)
<223>  Xaa is D, E, N, I, A, K or P

<220>
<221>  Xaa
<222>  (393)..(393)
<223>  Xaa is L, K, S, I, V or Y

<220>
<221>  Xaa
<222>  (394)..(394)
<223>  Xaa is L, K, D, Q, V, I, A or Y

<220>
<221>  Xaa
<222>  (395)..(395)
<223>  Xaa is A, S, K, G, Y or D

<220>
<221>  Xaa
<222>  (396)..(396)
<223>  Xaa is L, I, F, D, V or G

<220>
<221>  Xaa
<222>  (397)..(397)
<223>  Xaa is A, I, K, S, Q or M

<220>
<221>  Xaa
<222>  (398)..(398)
<223>  Xaa is A, E, Y, F, I, L, V or K

<220>
<221>  Xaa
<222>  (399)..(399)
<223>  Xaa is A, C, G, P, S, V, I or W

<220>
<221>  Xaa
<222>  (400)..(400)
<223>  Xaa is R, S, V, E, I, L, F, T, N or W

<220>
<221>  Xaa
<222>  (401)..(401)
<223>  Xaa is G, D, E, N, P or K

<220>
<221>  Xaa
<222>  (402)..(402)
<223>  Xaa is G, Y, P, S, E, H, K, N or F

<220>
<221>  Xaa
<222>  (403)..(403)
<223>  Xaa is R, T, F, E, G, K, D or N

<220>
<221>  Xaa
<222>  (404)..(404)
<223>  Xaa is V, L, I, G, E, R, T or N

<220>
<221>  Xaa
<222>  (405)..(405)
<223>  Xaa is H, S, G, A, F, V or E

<220>
<221>  Xaa
<222>  (406)..(406)
<223>  Xaa is L, A, Y, F, T or M

<220>
<221>  Xaa
<222>  (407)..(407)
<223>  Xaa is V, Y, L, I or M

<220>
<221>  Xaa
<222>  (408)..(408)
<223>  Xaa is V or I

<220>
<221>  Xaa
<222>  (409)..(409)
<223>  Xaa is S or P

<220>
<221>  Xaa
<222>  (410)..(410)
<223>  Xaa is I, V or L

<220>
<221>  Xaa
<222>  (411)..(411)
<223>  Xaa is N, A, H or S

<220>
<221>  Xaa
<222>  (412)..(412)
<223>  Xaa is D or H

<220>
<221>  Xaa
<222>  (413)..(413)
<223>  Xaa is L, D, K, R or V

<220>
<221>  Xaa
<222>  (414)..(414)
<223>  Xaa is I or Y

<220>
<221>  Xaa
<222>  (415)..(415)
<223>  Xaa is F or L

<220>
<221>  Xaa
<222>  (416)..(416)
<223>  Xaa is Y or D

<220>
<221>  Xaa
<222>  (417)..(417)
<223>  Xaa is V, A, N or S

<220>
<221>  Xaa
<222>  (418)..(418)
<223>  Xaa is P, G, A, E or D

<220>
<221>  Xaa
<222>  (419)..(419)
<223>  Xaa is E, D, P, Q, N or Y

<220>
<221>  Xaa
<222>  (420)..(420)
<223>  Xaa is R, E, P, K, Q, N or D

<220>
<221>  Xaa
<222>  (421)..(421)
<223>  Xaa is A, I, F, L, V or P

<220>
<221>  Xaa
<222>  (422)..(422)
<223>  Xaa is P, A, T, D, L, S, E, H or Q

<220>
<221>  Xaa
<222>  (423)..(423)
<223>  Xaa is E, D, S, F, R, K, M, T or N

<220>
<221>  Xaa
<222>  (424)..(424)
<223>  Xaa is P, N, Q, E, K, A, V, G or L

<220>
<221>  Xaa
<222>  (425)..(425)
<223>  Xaa is Y, L, V, D, N, R, S, E, I, F or K

<220>
<221>  Xaa
<222>  (426)..(426)
<223>  Xaa is K, A, E, T, L, V, Q or F

<220>
<221>  Xaa
<222>  (427)..(427)
<223>  Xaa is I, A, L, D or T

<220>
<221>  Xaa
<222>  (428)..(428)
<223>  Xaa is R, E, N, K, S, P or M

<220>
<221>  Xaa
<222>  (429)..(429)
<223>  Xaa is K, T, L, N, F, Q, D, H or A

<220>
<221>  Xaa
<222>  (430)..(430)
<223>  Xaa is A, G, R, K, I, L or F

<220>
<221>  Xaa
<222>  (431)..(431)
<223>  Xaa is L, V, I, A, K or Y

<220>
<221>  Xaa
<222>  (432)..(432)
<223>  Xaa is R, K, A, N, E, P or S

<220>
<221>  Xaa
<222>  (433)..(433)
<223>  Xaa is D, E, N, K, L, I, W or Y

<220>
<221>  Xaa
<222>  (434)..(434)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (435)..(435)
<223>  Xaa is K, L, I, E, A or G

<220>
<221>  Xaa
<222>  (436)..(436)
<223>  Xaa is E, S, K, D, N, C or G

<220>
<221>  Xaa
<222>  (437)..(437)
<223>  Xaa is A, V, S, G, E, Q, P, L or D

<220>
<221>  Xaa
<222>  (438)..(438)
<223>  Xaa is R, E, N, K, S, G, T or D

<220>
<221>  Xaa
<222>  (439)..(439)
<223>  Xaa is G, I, N, D, A, Y, K, F or H

<220>
<221>  Xaa
<222>  (440)..(440)
<223>  Xaa is L, F, V, K, E, D or Y

<220>
<221>  Xaa
<222>  (441)..(441)
<223>  Xaa is L, K, I or F

<220>
<221>  Xaa
<222>  (442)..(442)
<223>  Xaa is A, I, K, G, V, S, T or P

<220>
<221>  Xaa
<222>  (443)..(443)
<223>  Xaa is K, I, T, G, M, H or P

<220>
<221>  Xaa
<222>  (444)..(444)
<223>  Xaa is D, Y, G, E, Q, F, H or K

<220>
<221>  Xaa
<222>  (445)..(445)
<223>  Xaa is L, N, S, T, D, E or I

<220>
<221>  Xaa
<222>  (446)..(446)
<223>  Xaa is S, A, Y, E, L, I, R or D

<220>
<221>  Xaa
<222>  (447)..(447)
<223>  Xaa is V, K, I, D, R or F

<220>
<221>  Xaa
<222>  (448)..(448)
<223>  Xaa is L, E, Q, A, Y, F, R, D or T

<220>
<221>  Xaa
<222>  (449)..(449)
<223>  Xaa is A, P, D, F or H

<220>
<221>  Xaa
<222>  (450)..(450)
<223>  Xaa is L, S, K, R, Y, A, D or V

<220>
<221>  Xaa
<222>  (451)..(451)
<223>  Xaa is R, K, L, G, S, V or T

<220>
<221>  Xaa
<222>  (452)..(452)
<223>  Xaa is E, K, D, I, V, A, R, M or Y

<220>
<221>  Xaa
<222>  (453)..(453)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (454)..(454)
<223>  Xaa is K, H, A, M, S, Q or T

<220>
<221>  Xaa
<222>  (455)..(455)
<223>  Xaa is N, F, S, M, V, W, Y or H

<220>
<221>  Xaa
<222>  (456)..(456)
<223>  Xaa is S, L, Y, H, K, N or W

<220>
<221>  Xaa
<222>  (457)..(457)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (458)..(458)
<223>  Xaa is L, V, C, I or E

<220>
<221>  Xaa
<222>  (459)..(459)
<223>  Xaa is G, D, A, K, E or S

<220>
<221>  Xaa
<222>  (460)..(460)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (461)..(461)
<223>  Xaa is S, K, I, R, V, Q, C or E

<220>
<221>  Xaa
<222>  (462)..(462)
<223>  Xaa is P, V, D, G, W, R, I, S or A

<220>
<221>  Xaa
<222>  (463)..(463)
<223>  Xaa is P, D, H, I, V, K or G

<220>
<221>  Xaa
<222>  (464)..(464)
<223>  Xaa is G, T, Y , V,  L,  A, S, H or D

<220>
<221>  Xaa
<222>  (465)..(465)
<223>  Xaa is F

<220>
<221>  Xaa
<222>  (466)..(466)
<223>  Xaa is K or G

<220>
<221>  Xaa
<222>  (467)..(467)
<223>  Xaa is N or L

<220>
<221>  Xaa
<222>  (468)..(468)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (469)..(469)
<223>  Xaa is P, L, V, T, S or H

<220>
<221>  Xaa
<222>  (470)..(470)
<223>  Xaa is M, L, S, E, A or R

<220>
<221>  Xaa
<222>  (471)..(471)
<223>  Xaa is L, I, V or A

<220>
<221>  Xaa
<222>  (472)..(472)
<223>  Xaa is L, V, R, D, E, A or M

<220>
<221>  Xaa
<222>  (473)..(473)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (474)..(474)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (475)..(475)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (476)..(476)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (477)..(477)
<223>  Xaa is D, N, E or K

<220>
<221>  Xaa
<222>  (478)..(478)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (479)..(479)
<223>  Xaa is S, A, N, E, V, D or G

<220>
<221>  Xaa
<222>  (480)..(480)
<223>  Xaa is R, K, A, E, Q or D

<220>
<221>  Xaa
<222>  (481)..(481)
<223>  Xaa is G, Q, F, K, R, D, S, Y or N

<220>
<221>  Xaa
<222>  (482)..(482)
<223>  Xaa is N, K, L, R, A, V, D or G

<220>
<221>  Xaa
<222>  (483)..(483)
<223>  Xaa is T, Y, H, F, G or D

<220>
<221>  Xaa
<222>  (484)..(484)
<223>  Xaa is T, H, N, S, Y, D, E or P

<220>
<221>  Xaa
<222>  (485)..(485)
<223>  Xaa is P, I, L, D, M, V or F

<220>
<221>  Xaa
<222>  (486)..(486)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (487)..(487)
<223>  Xaa is G, E, I, S, D, A, R, K or T

<220>
<221>  Xaa
<222>  (488)..(488)
<223>  Xaa is V, L , A, F or K

<220>
<221>  Xaa
<222>  (489)..(489)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (490)..(490)
<223>  Xaa is R, L, G, A, E, M, K, D or I

<220>
<221>  Xaa
<222>  (491)..(491)
<223>  Xaa is R, E, Y, K, M or D

<220>
<221>  Xaa
<222>  (492)..(492)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (493)..(493)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (494)..(494)
<223>  Xaa is G, N, E, K or Y

<220>
<221>  Xaa
<222>  (495)..(495)
<223>  Xaa is P, H, Y, E, V or A

<220>
<221>  Xaa
<222>  (496)..(496)
<223>  Xaa is T, K, A, D or H

<220>
<221>  Xaa
<222>  (497)..(497)
<223>  Xaa is E, T, M, V or K

<220>
<221>  Xaa
<222>  (498)..(498)
<223>  Xaa is A, I , T, R or P

<220>
<221>  Xaa
<222>  (499)..(499)
<223>  Xaa is P, T, S or K

<220>
<221>  Xaa
<222>  (500)..(500)
<223>  Xaa is H, F, Y, D or K

<220>
<221>  Xaa
<222>  (501)..(501)
<223>  Xaa is S, E or Q

<220>
<221>  Xaa
<222>  (502)..(502)
<223>  Xaa is I, E, A, G or D

<220>
<221>  Xaa
<222>  (503)..(503)
<223>  Xaa is E, I , L, V or F

<220>
<221>  Xaa
<222>  (504)..(504)
<223>  Xaa is D, A, F, M, V or Y

<220>
<221>  Xaa
<222>  (505)..(505)
<223>  Xaa is M, G, K, S or D

<220>
<221>  Xaa
<222>  (506)..(506)
<223>  Xaa is M, K, D, F or M

<220>
<221>  Xaa
<222>  (507)..(507)
<223>  Xaa is N, G, T or S

<220>
<221>  Xaa
<222>  (508)..(508)
<223>  Xaa is R, K, S, F, M or A

<220>
<221>  Xaa
<222>  (509)..(509)
<223>  Xaa is Y, N, P or D

<220>
<221>  Xaa
<222>  (510)..(510)
<223>  Xaa is Y, Q, L or K

<220>
<221>  Xaa
<222>  (511)..(511)
<223>  Xaa is F

<220>
<221>  Xaa
<222>  (512)..(512)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (513)..(513)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (514)..(514)
<223>  Xaa is G, L, V, F, N or K

<220>
<221>  Xaa
<222>  (515)..(515)
<223>  Xaa is Q, T, S, D or K

<220>
<221>  Xaa
<222>  (516)..(516)
<223>  Xaa is F, R, I, L or Y

<220>
<221>  Xaa
<222>  (517)..(517)
<223>  Xaa is D, N, A, V, S or E

<220>
<221>  Xaa
<222>  (518)..(518)
<223>  Xaa is L, Q, D, F, V or E

<220>
<221>  Xaa
<222>  (519)..(519)
<223>  Xaa is T, I , V or P

<220>
<221>  Xaa
<222>  (520)..(520)
<223>  Xaa is P, A, S, D or G

<220>
<221>  Xaa
<222>  (521)..(521)
<223>  Xaa is Y, L, V, I, E or F

<220>
<221>  Xaa
<222>  (522)..(522)
<223>  Xaa is G, E, P, N or D

<220>
<221>  Xaa
<222>  (523)..(523)
<223>  Xaa is E, K, Q, D, T, V or I

<220>
<221>  Xaa
<222>  (524)..(524)
<223>  Xaa is W, F, T, D, A, L, M or Y

<220>
<221>  Xaa
<222>  (525)..(525)
<223>  Xaa is T, Y, S, W, G, A or V

<220>
<221>  Xaa
<222>  (526)..(526)
<223>  Xaa is E, F, Q, R, K, N, D or P

<220>
<221>  Xaa
<222>  (527)..(527)
<223>  Xaa is E, D, N, I, A, Y, H or L

<220>
<221>  Xaa
<222>  (528)..(528)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (529)..(529)
<223>  Xaa is G, A, E, Q, C, R or V

<220>
<221>  Xaa
<222>  (530)..(530)
<223>  Xaa is E, H, N, K, R or S

<220>
<221>  Xaa
<222>  (531)..(531)
<223>  Xaa is R, I, Y, D or K

<220>
<221>  Xaa
<222>  (532)..(532)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (533)..(533)
<223>  Xaa is A, L, F, G, D, V or E

<220>
<221>  Xaa
<222>  (534)..(534)
<223>  Xaa is L, Y, I, V, A or H

<220>
<221>  Xaa
<222>  (535)..(535)
<223>  Xaa is S, M, L, T or I

<220>
<221>  Xaa
<222>  (536)..(536)
<223>  Xaa is E, F, L, R, Y, W or I

<220>
<221>  Xaa
<222>  (537)..(537)
<223>  Xaa is R, E, P, D, Q, A or K

<220>
<221>  Xaa
<222>  (538)..(538)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (539)..(539)
<223>  Xaa is F, H, Y, K or T

<220>
<221>  Xaa
<222>  (540)..(540)
<223>  Xaa is A, R, Q, E, S, I, L, Y, K or N

<220>
<221>  Xaa
<222>  (541)..(541)
<223>  Xaa is N, K, I, S, E, R, F or T

<220>
<221>  Xaa
<222>  (542)..(542)
<223>  Xaa is L, P, M, I, T, Y, K or F

<220>
<221>  Xaa
<222>  (543)..(543)
<223>  Xaa is W, L, F, N, E or G

<220>
<221>  Xaa
<222>  (544)..(544)
<223>  Xaa is G, K, P, E, N, S, L or M

<220>
<221>  Xaa
<222>  (545)..(545)
<223>  Xaa is R, E, D, I, L, K, N or W

<220>
<221>  Xaa
<222>  (546)..(546)
<223>  Xaa is L, I, K, Y, E or F

<220>
<221>  Xaa
<222>  (547)..(547)
<223>  Xaa is E, Q, S, K, L or I

<220>
<221>  Xaa
<222>  (548)..(548)
<223>  Xaa is G, Q, K, H, R, E or P

<220>
<221>  Xaa
<222>  (549)..(549)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (550)..(550)
<223>  Xaa is E, K, R, A, N, M or G

<220>
<221>  Xaa
<222>  (551)..(551)
<223>  Xaa is R, K E, G, N or D

<220>
<221>  Xaa
<222>  (552)..(552)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (553)..(553)
<223>  Xaa is L, E, W, K, D or C

<220>
<221>  Xaa
<222>  (554)..(554)
<223>  Xaa is W, N, F, Q, E, G, R, K, S or M

<220>
<221>  Xaa
<222>  (555)..(555)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (556)..(556)
<223>  Xaa is Y, L , F or C

<220>
<221>  Xaa
<222>  (557)..(557)
<223>  Xaa is R, H, Q, F, Y, K, E, I, V or L

<220>
<221>  Xaa
<222>  (558)..(558)
<223>  Xaa is E, D, N, K or P

<220>
<221>  Xaa
<222>  (559)..(559)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (560)..(560)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (561)..(561)
<223>  Xaa is R, K, M, I, L, Q or G

<220>
<221>  Xaa
<222>  (562)..(562)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (563)..(563)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (564)..(564)
<223>  Xaa is S, I, A, V, C or L

<220>
<221>  Xaa
<222>  (565)..(565)
<223>  Xaa is A, R, E, P, F, S, N, T or V

<220>
<221>  Xaa
<222>  (566)..(566)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (567)..(567)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (568)..(568)
<223>  Xaa is A, F, Y, S, V, K, Q or P

<220>
<221>  Xaa
<222>  (569)..(569)
<223>  Xaa is H, D, S, R, Q or E

<220>
<221>  Xaa
<222>  (570)..(570)
<223>  Xaa is M

<220>
<221>  Xaa
<222>  (571)..(571)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (572)..(572)
<223>  Xaa is A, E, K, F, R, L, V, D or T

<220>
<221>  Xaa
<222>  (573)..(573)
<223>  Xaa is T, R, W, N, E, A, S or P

<220>
<221>  Xaa
<222>  (574)..(574)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (575)..(575)
<223>  Xaa is V, I or F

<220>
<221>  Xaa
<222>  (576)..(576)
<223>  Xaa is R, K, Y, T, P or G

<220>
<221>  Xaa
<222>  (577)..(577)
<223>  Xaa is L, V, I, M, F or G

<220>
<221>  Xaa
<222>  (578)..(578)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (579)..(579)
<223>  Xaa is V, I, K, A, P, T or F

<220>
<221>  Xaa
<222>  (580)..(580)
<223>  Xaa is A, P, E, R, K or D

<220>
<221>  Xaa
<222>  (581)..(581)
<223>  Xaa is Y, L, K, V, F or R

<220>
<221>  Xaa
<222>  (582)..(582)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (583)..(583)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (584)..(584)
<223>  Xaa is A, T, Q, E, N, D or K

<220>
<221>  Xaa
<222>  (585)..(585)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (586)..(586)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (587)..(587)
<223>  Xaa is L, F, K, D, A, E, S, Q or Y

<220>
<221>  Xaa
<222>  (588)..(588)
<223>  Xaa is E, H, N, K, R or Q

<220>
<221>  Xaa
<222>  (589)..(589)
<223>  Xaa is V, L, I, F, Y or E

<220>
<221>  Xaa
<222>  (590)..(590)
<223>  Xaa is A, E, S, C, D, T, G or N

<220>
<221>  Xaa
<222>  (591)..(591)
<223>  Xaa is E, K, M, H, L, A, D or R

<220>
<221>  Xaa
<222>  (592)..(592)
<223>  Xaa is E, R, K, Q or N

<220>
<221>  Xaa
<222>  (593)..(593)
<223>  Xaa is I, M, L or P

<220>
<221>  Xaa
<222>  (594)..(594)
<223>  Xaa is A, R, E, D, K, S, N, G or C

<220>
<221>  Xaa
<222>  (595)..(595)
<223>  Xaa is  R, K, E, A or T

<220>
<221>  Xaa
<222>  (596)..(596)
<223>  Xaa is  L

<220>
<221>  Xaa
<222>  (597)..(597)
<223>  Xaa is  E, K, S, A, L, R or D

<220>
<221>  Xaa
<222>  (598)..(598)
<223>  Xaa is  A, E, G, T, K or Q

<220>
<221>  Xaa
<222>  (599)..(599)
<223>  Xaa is E, K, Q or R

<220>
<221>  Xaa
<222>  (600)..(600)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (601)..(601)
<223>  Xaa is F, Y or H

<220>
<221>  Xaa
<222>  (602)..(602)
<223>  Xaa is R, T, E, N, K or V

<220>
<221>  Xaa
<222>  (603)..(603)
<223>  Xaa is L, I, H, E, Y or A

<220>
<221>  Xaa
<222>  (604)..(604)
<223>  Xaa is P or G

<220>
<221>  Xaa
<222>  (605)..(605)
<223>  Xaa is E or A

<220>
<221>  Xaa
<222>  (606)..(606)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (607)..(607)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (608)..(608)
<223>  Xaa is Q or P

<220>
<221>  Xaa
<222>  (609)..(609)
<223>  Xaa is L or Y

<220>
<221>  Xaa
<222>  (610)..(610)
<223>  Xaa is E or T

<220>
<221>  Xaa
<222>  (611)..(611)
<223>  Xaa is Q or P

<220>
<221>  Xaa
<222>  (612)..(612)
<223>  Xaa is D or V

<220>
<221>  Xaa
<222>  (613)..(613)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (614)..(614)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (615)..(615)
<223>  Xaa is H, T, E, Q, Y or V

<220>
<221>  Xaa
<222>  (616)..(616)
<223>  Xaa is P, E, R, A, Q or V

<220>
<221>  Xaa
<222>  (617)..(617)
<223>  Xaa is F

<220>
<221>  Xaa
<222>  (618)..(618)
<223>  Xaa is N

<220>
<221>  Xaa
<222>  (619)..(619)
<223>  Xaa is L, I, V or P

<220>
<221>  Xaa
<222>  (620)..(620)
<223>  Xaa is N

<220>
<221>  Xaa
<222>  (621)..(621)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (622)..(622)
<223>  Xaa is R, P, T, S or V

<220>
<221>  Xaa
<222>  (623)..(623)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (624)..(624)
<223>  Xaa is Q

<220>
<221>  Xaa
<222>  (625)..(625)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (626)..(626)
<223>  Xaa is E, A, S, G, Q or R

<220>
<221>  Xaa
<222>  (627)..(627)
<223>  Xaa is R, E, Y, T, H, V or K

<220>
<221>  Xaa
<222>  (628)..(628)
<223>  Xaa is V, I, F, L or K

<220>
<221>  Xaa
<222>  (629)..(629)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (630)..(630)
<223>  Xaa is F

<220>
<221>  Xaa
<222>  (631)..(631)
<223>  Xaa is D or E

<220>
<221>  Xaa
<222>  (632)..(632)
<223>  Xaa is E, R, K, Y or A

<220>
<221>  Xaa
<222>  (633)..(633)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (634)..(634)
<223>  Xaa is G, R, K, Q, N or W

<220>
<221>  Xaa
<222>  (635)..(635)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (636)..(636)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (637)..(637)
<223>  Xaa is A, P, T, S, V or I

<220>
<221>  Xaa
<222>  (638)..(638)
<223>  Xaa is I, L, V, T or R

<220>
<221>  Xaa
<222>  (639)..(639)
<223>  Xaa is G, R or K

<220>
<221>  Xaa
<222>  (640)..(640)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (641)..(641)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (642)..(642)
<223>  Xaa is E, Q, G, K, P, S, T or A

<220>
<221>  Xaa
<222>  (643)..(643)
<223>  Xaa is K or D

<220>
<221>  Xaa
<222>  (644)..(644)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (645)..(645)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (646)..(646)
<223>  Xaa is K, Y, A, E, D or R

<220>
<221>  Xaa
<222>  (647)..(647)
<223>  Xaa is R, Y, P, N or D

<220>
<221>  Xaa
<222>  (648)..(648)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (649)..(649)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (650)..(650)
<223>  Xaa is S, A, E, D, R or N

<220>
<221>  Xaa
<222>  (651)..(651)
<223>  Xaa is A, Q, M, S, E, I or D

<220>
<221>  Xaa
<222>  (652)..(652)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (653)..(653)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (654)..(654)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (655)..(655)
<223>  Xaa is E, Q or N

<220>
<221>  Xaa
<222>  (656)..(656)
<223>  Xaa is A, E, N, T, K, Q or G

<220>
<221>  Xaa
<222>  (657)..(657)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (658)..(658)
<223>  Xaa is R, A, I, S or V

<220>
<221>  Xaa
<222>  (659)..(659)
<223>  Xaa is E, G, I, N, H, L, K, P, T or V

<220>
<221>  Xaa
<222>  (660)..(660)
<223>  Xaa is A, Q, D, E, H or Y

<220>
<221>  Xaa
<222>  (661)..(661)
<223>  Xaa is H

<220>
<221>  Xaa
<222>  (662)..(662)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (663)..(663)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (664)..(664)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (665)..(665)
<223>  Xaa is Q

<220>
<221>  Xaa
<222>  (666)..(666)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (667)..(667)
<223>  Xaa is V, P, C, I or A

<220>
<221>  Xaa
<222>  (668)..(668)
<223>  Xaa is E, H, R, K, P, S, N or I

<220>
<221>  Xaa
<222>  (669)..(669)
<223>  Xaa is K, L, E, V, N, D or T

<220>
<221>  Xaa
<222>  (670)..(670)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (671)..(671)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (672)..(672)
<223>  Xaa is Q or K

<220>
<221>  Xaa
<222>  (673)..(673)
<223>  Xaa is Q, N, D, E or H

<220>
<221>  Xaa
<222>  (674)..(674)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (675)..(675)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (676)..(676)
<223>  Xaa is E, T, Q, G, K or M

<220>
<221>  Xaa
<222>  (677)..(677)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (678)..(678)
<223>  Xaa is T, S, N, Y, H, A, Q or G

<220>
<221>  Xaa
<222>  (679)..(679)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (680)..(680)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (681)..(681)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (682)..(682)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (683)..(683)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (684)..(684)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (685)..(685)
<223>  Xaa is I, V, L, T or A

<220>
<221>  Xaa
<222>  (686)..(686)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (687)..(687)
<223>  Xaa is P, A, G, K , V, S or G

<220>
<221>  Xaa
<222>  (688)..(688)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (689)..(689)
<223>  Xaa is P, R, K or L

<220>
<221>  Xaa
<222>  (690)..(690)
<223>  Xaa is D, S, R, N, K, P or A

<220>
<221>  Xaa
<222>  (691)..(691)
<223>  Xaa is L, Y, M, S, V or W

<220>
<221>  Xaa
<222>  (692)..(692)
<223>  Xaa is I, V, M or L

<220>
<221>  Xaa
<222>  (693)..(693)
<223>  Xaa is H, S, N, R or D

<220>
<221>  Xaa
<222>  (694)..(694)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (695)..(695)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (696)..(696)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (697)..(697)
<223>  Xaa is R, N, E, Q, T, K or D

<220>
<221>  Xaa
<222>  (698)..(698)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (699)..(699)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (700)..(700)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (701)..(701)
<223>  Xaa is L, I or V

<220>
<221>  Xaa
<222>  (702)..(702)
<223>  Xaa is H

<220>
<221>  Xaa
<222>  (703)..(703)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (704)..(704)
<223>  Xaa is R, K, T, S, M, I, N or G

<220>
<221>  Xaa
<222>  (705)..(705)
<223>  Xaa is F

<220>
<221>  Xaa
<222>  (706)..(706)
<223>  Xaa is N

<220>
<221>  Xaa
<222>  (707)..(707)
<223>  Xaa is Q

<220>
<221>  Xaa
<222>  (708)..(708)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (709)..(709)
<223>  Xaa is A, V, G, I, L or M

<220>
<221>  Xaa
<222>  (710)..(710)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (711)..(711)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (712)..(712)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (713)..(713)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (714)..(714)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (715)..(715)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (716)..(716)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (717)..(717)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (718)..(718)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (719)..(719)
<223>  Xaa is D, E, A, G or F

<220>
<221>  Xaa
<222>  (720)..(720)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (721)..(721)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (722)..(722)
<223>  Xaa is N

<220>
<221>  Xaa
<222>  (723)..(723)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (724)..(724)
<223>  Xaa is Q

<220>
<221>  Xaa
<222>  (725)..(725)
<223>  Xaa is N or Q

<220>
<221>  Xaa
<222>  (726)..(726)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (727)..(727)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (728)..(728)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (729)..(729)
<223>  Xaa is V, I, S or T

<220>
<221>  Xaa
<222>  (730)..(730)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (731)..(731)
<223>  Xaa is T, G, S, L, N or Q

<220>
<221>  Xaa
<222>  (732)..(732)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (733)..(733)
<223>  Xaa is L, W, E, F, R or Y

<220>
<221>  Xaa
<222>  (734)..(734)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (735)..(735)
<223>  Xaa is Q, E, R or K

<220>
<221>  Xaa
<222>  (736)..(736)
<223>  Xaa is R, F, K, E, Q or S

<220>
<221>  Xaa
<222>  (737)..(737)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (738)..(738)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (739)..(739)
<223>  Xaa is R, K, E, Q, H or A

<220>
<221>  Xaa
<222>  (740)..(740)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (741)..(741)
<223>  Xaa is F

<220>
<221>  Xaa
<222>  (742)..(742)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (743)..(743)
<223>  Xaa is A, P, S, I or V

<220>
<221>  Xaa
<222>  (744)..(744)
<223>  Xaa is E, Q, P, S, R or A

<220>
<221>  Xaa
<222>  (745)..(745)
<223>  Xaa is E, A, N, D, R, F, S, T, H or P

<220>
<221>  Xaa
<222>  (746)..(746)
<223>  Xaa is S, D, P, E, R, K or H

<220>
<221>  Xaa
<222>  (747)..(747)
<223>  Xaa is G, D, S, N or L

<220>
<221>  Xaa
<222>  (748)..(748)
<223>  Xaa is W, Y, Q, G or D

<220>
<221>  Xaa
<222>  (749)..(749)
<223>  Xaa is L, A, M, F, V, K, W, Y, R or G

<220>
<221>  Xaa
<222>  (750)..(750)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (751)..(751)
<223>  Xaa is V, L, F, I or T

<220>
<221>  Xaa
<222>  (752)..(752)
<223>  Xaa is A, S or G

<220>
<221>  Xaa
<222>  (753)..(753)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (754)..(754)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (755)..(755)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (756)..(756)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (757)..(757)
<223>  Xaa is Q

<220>
<221>  Xaa
<222>  (758)..(758)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (759)..(759)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (760)..(760)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (761)..(761)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (762)..(762)
<223>  Xaa is V, L, I, Y or A

<220>
<221>  Xaa
<222>  (763)..(763)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (764)..(764)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (765)..(765)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (766)..(766)
<223>  Xaa is H

<220>
<221>  Xaa
<222>  (767)..(767)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (768)..(768)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (769)..(769)
<223>  Xaa is G, E, Q, R, N, D or C

<220>
<221>  Xaa
<222>  (770)..(770)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (771)..(771)
<223>  Xaa is E, P, T, K, Q, R or A

<220>
<221>  Xaa
<222>  (772)..(772)
<223>  Xaa is N

<220>
<221>  Xaa
<222>  (773)..(773)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (774)..(774)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (775)..(775)
<223>  Xaa is R, K, S, Q, T, E, D or A

<220>
<221>  Xaa
<222>  (776)..(776)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (777)..(777)
<223>  Xaa is F

<220>
<221>  Xaa
<222>  (778)..(778)
<223>  Xaa is Q, R, L, A, K, E, M, I or D

<220>
<221>  Xaa
<222>  (779)..(779)
<223>  Xaa is E, D, K, N or R

<220>
<221>  Xaa
<222>  (780)..(780)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (781)..(781)
<223>  Xaa is R, K, E, Q, Y, I or L

<220>
<221>  Xaa
<222>  (782)..(782)
<223>  Xaa is N

<220>
<221>  Xaa
<222>  (783)..(783)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (784)..(784)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (785)..(785)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (786)..(786)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (787)..(787)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (788)..(788)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (789)..(789)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (790)..(790)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (791)..(791)
<223>  Xaa is H

<220>
<221>  Xaa
<222>  (792)..(792)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (793)..(793)
<223>  Xaa is E, Q, A, R, F, L, I, K or N

<220>
<221>  Xaa
<222>  (794)..(794)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (795)..(795)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (796)..(796)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (797)..(797)
<223>  Xaa is W, E, Q, R, K, D or M

<220>
<221>  Xaa
<222>  (798)..(798)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (799)..(799)
<223>  Xaa is F

<220>
<221>  Xaa
<222>  (800)..(800)
<223>  Xaa is G, S, E, Q, N, H, K or T

<220>
<221>  Xaa
<222>  (801)..(801)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (802)..(802)
<223>  Xaa is P, D, E, K, S, Q or N

<220>
<221>  Xaa
<222>  (803)..(803)
<223>  Xaa is R, P, E, S, L, M, C or Q

<220>
<221>  Xaa
<222>  (804)..(804)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (805)..(805)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (806)..(806)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (807)..(807)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (808)..(808)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (809)..(809)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (810)..(810)
<223>  Xaa is A, L , E, Q, T, M or K

<220>
<221>  Xaa
<222>  (811)..(811)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (812)..(812)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (813)..(813)
<223>  Xaa is P, D, R, S, E, A or L

<220>
<221>  Xaa
<222>  (814)..(814)
<223>  Xaa is L, K, E, Q, D, T, N, A or P

<220>
<221>  Xaa
<222>  (815)..(815)
<223>  Xaa is M

<220>
<221>  Xaa
<222>  (816)..(816)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (817)..(817)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (818)..(818)
<223>  Xaa is A, I , R, H, S, Q or N

<220>
<221>  Xaa
<222>  (819)..(819)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (820)..(820)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (821)..(821)
<223>  Xaa is T, A or M

<220>
<221>  Xaa
<222>  (822)..(822)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (823)..(823)
<223>  Xaa is N

<220>
<221>  Xaa
<222>  (824)..(824)
<223>  Xaa is F or Y

<220>
<221>  Xaa
<222>  (825)..(825)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (826)..(826)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (827)..(827)
<223>  Xaa is L, S, I or V

<220>
<221>  Xaa
<222>  (828)..(828)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (829)..(829)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (830)..(830)
<223>  Xaa is M, I, V, S or A

<220>
<221>  Xaa
<222>  (831)..(831)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (832)..(832)
<223>  Xaa is A, P, S or D

<220>
<221>  Xaa
<222>  (833)..(833)
<223>  Xaa is H, F, Y, A or E

<220>
<221>  Xaa
<222>  (834)..(834)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (835)..(835)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (836)..(836)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (837)..(837)
<223>  Xaa is Q, E, R, V or H

<220>
<221>  Xaa
<222>  (838)..(838)
<223>  Xaa is E, S, T, Q, R, N, D or I

<220>
<221>  Xaa
<222>  (839)..(839)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (840)..(840)
<223>  Xaa is A, G, K, S or N

<220>
<221>  Xaa
<222>  (841)..(841)
<223>  Xaa is E or A

<220>
<221>  Xaa
<222>  (842)..(842)
<223>  Xaa is A or G

<220>
<221>  Xaa
<222>  (843)..(843)
<223>  Xaa is L or K

<220>
<221>  Xaa
<222>  (844)..(844)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (845)..(845)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (846)..(846)
<223>  Xaa is Q

<220>
<221>  Xaa
<222>  (847)..(847)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (848)..(848)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (849)..(849)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (850)..(850)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (851)..(851)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (852)..(852)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (853)..(853)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (854)..(854)
<223>  Xaa is F

<220>
<221>  Xaa
<222>  (855)..(855)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (856)..(856)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (857)..(857)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (858)..(858)
<223>  Xaa is P, D, T, S, N or G

<220>
<221>  Xaa
<222>  (859)..(859)
<223>  Xaa is Y, P, R, V or K

<220>
<221>  Xaa
<222>  (860)..(860)
<223>  Xaa is E, K, D, N or A

<220>
<221>  Xaa
<222>  (861)..(861)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (862)..(862)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (863)..(863)
<223>  Xaa is Q, V, E or K

<220>
<221>  Xaa
<222>  (864)..(864)
<223>  Xaa is A, E, K or T

<220>
<221>  Xaa
<222>  (865)..(865)
<223>  Xaa is F, L, Y, M or I

<220>
<221>  Xaa
<222>  (866)..(866)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (867)..(867)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (868)..(868)
<223>  Xaa is R, L, S, N, E or T

<220>
<221>  Xaa
<222>  (869)..(869)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (870)..(870)
<223>  Xaa is F

<220>
<221>  Xaa
<222>  (871)..(871)
<223>  Xaa is Q, L, K, T, E, S, V, A or G

<220>
<221>  Xaa
<222>  (872)..(872)
<223>  Xaa is S, R, H, L, Y, Q or I

<220>
<221>  Xaa
<222>  (873)..(873)
<223>  Xaa is F, Y or A

<220>
<221>  Xaa
<222>  (874)..(874)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (875)..(875)
<223>  Xaa is K, M, R, G, S, Q or L

<220>
<221>  Xaa
<222>  (876)..(876)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (877)..(877)
<223>  Xaa is R, K, L, F or E

<220>
<221>  Xaa
<222>  (878)..(878)
<223>  Xaa is A, K, L, E, Q, D, R or S

<220>
<221>  Xaa
<222>  (879)..(879)
<223>  Xaa is W, F, Y or I

<220>
<221>  Xaa
<222>  (880)..(880)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (881)..(881)
<223>  Xaa is E, D, A, Q or K

<220>
<221>  Xaa
<222>  (882)..(882)
<223>  Xaa is K, R, E, Q, T or N

<220>
<221>  Xaa
<222>  (883)..(883)
<223>  Xaa is T, I, V, C or L

<220>
<221>  Xaa
<222>  (884)..(884)
<223>  Xaa is L, I, V, R or H

<220>
<221>  Xaa
<222>  (885)..(885)
<223>  Xaa is E, S, H, N, A, D, Q or R

<220>
<221>  Xaa
<222>  (886)..(886)
<223>  Xaa is E, F, Q, Y or S

<220>
<221>  Xaa
<222>  (887)..(887)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (888)..(888)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (889)..(889)
<223>  Xaa is R, K, T, E, M, Q, N or W

<220>
<221>  Xaa
<222>  (890)..(890)
<223>  Xaa is R, N, K, Q, H or V

<220>
<221>  Xaa
<222>  (891)..(891)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (892)..(892)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (893)..(893)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (894)..(894)
<223>  Xaa is E, R, K, T, Y or Q

<220>
<221>  Xaa
<222>  (895)..(895)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (896)..(896)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (897)..(897)
<223>  Xaa is F

<220>
<221>  Xaa
<222>  (898)..(898)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (899)..(899)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (900)..(900)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (901)..(901)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (902)..(902)
<223>  Xaa is Y, P, N, E, D, F, R or W

<220>
<221>  Xaa
<222>  (903)..(903)
<223>  Xaa is V, L or I

<220>
<221>  Xaa
<222>  (904)..(904)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (905)..(905)
<223>  Xaa is D, E, Q, N or G

<220>
<221>  Xaa
<222>  (906)..(906)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (907)..(907)
<223>  Xaa is E, N, A, K, S, R, M, T, H or D

<220>
<221>  Xaa
<222>  (908)..(908)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (909)..(909)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (910)..(910)
<223>  Xaa is N

<220>
<221>  Xaa
<222>  (911)..(911)
<223>  Xaa is K, R, Q, F, G, A or V

<220>
<221>  Xaa
<222>  (912)..(912)
<223>  Xaa is S, F, Q, N, A, T, G or H

<220>
<221>  Xaa
<222>  (913)..(913)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (914)..(914)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (915)..(915)
<223>  Xaa is E, M, N, S, A, Q or G

<220>
<221>  Xaa
<222>  (916)..(916)
<223>  Xaa is A, Q, E or F

<220>
<221>  Xaa
<222>  (917)..(917)
<223>  Xaa is A, S, Y, G or E

<220>
<221>  Xaa
<222>  (918)..(918)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (919)..(919)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (920)..(920)
<223>  Xaa is M, I, T, A, L or S

<220>
<221>  Xaa
<222>  (921)..(921)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (922)..(922)
<223>  Xaa is F, V, I, M or L

<220>
<221>  Xaa
<222>  (923)..(923)
<223>  Xaa is N

<220>
<221>  Xaa
<222>  (924)..(924)
<223>  Xaa is M, A or T

<220>
<221>  Xaa
<222>  (925)..(925)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (926)..(926)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (927)..(927)
<223>  Xaa is Q

<220>
<221>  Xaa
<222>  (928)..(928)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (929)..(929)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (930)..(930)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (931)..(931)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (932)..(932)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (933)..(933)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (934)..(934)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (935)..(935)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (936)..(936)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (937)..(937)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (938)..(938)
<223>  Xaa is M

<220>
<221>  Xaa
<222>  (939)..(939)
<223>  Xaa is V or I

<220>
<221>  Xaa
<222>  (940)..(940)
<223>  Xaa is K, R, E, A, N or D

<220>
<221>  Xaa
<222>  (941)..(941)
<223>  Xaa is L, I, V, A or T

<220>
<221>  Xaa
<222>  (942)..(942)
<223>  Xaa is F, Y, E, D, H, A, N

<220>
<221>  Xaa
<222>  (943)..(943)
<223>  Xaa is P, N, K, A, D, R or E

<220>
<221>  Xaa
<222>  (944)..(944)
<223>  Xaa is R, E, W, K, D or M

<220>
<221>  Xaa
<222>  (945)..(945)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (946)..(946)
<223>  Xaa is E, R, K, Q, I or V

<220>
<221>  Xaa
<222>  (947)..(947)
<223>  Xaa is E, P, K, N, A, Q, R or S

<220>
<221>  Xaa
<222>  (948)..(948)
<223>  Xaa is E, K, Q, M, R, N or L

<220>
<221>  Xaa
<222>  (949)..(949)
<223>  Xaa is K, N, D, Q, R, S or G

<220>
<221>  Xaa
<222>  (950)..(950)
<223>  Xaa is M or L

<220>
<221>  Xaa
<222>  (951)..(951)
<223>  Xaa is I, E or K

<220>
<221>  Xaa
<222>  (952)..(952)
<223>  Xaa is D, P, Q or H

<220>
<221>  Xaa
<222>  (953)..(953)
<223>  Xaa is G, N, K, R, Q or E

<220>
<221>  Xaa
<222>  (954)..(954)
<223>  Xaa is W

<220>
<221>  Xaa
<222>  (955)..(955)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (956)..(956)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (957)..(957)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (958)..(958)
<223>  Xaa is A, S, V, T, M or F

<220>
<221>  Xaa
<222>  (959)..(959)
<223>  Xaa is R, H, K or A

<220>
<221>  Xaa
<222>  (960)..(960)
<223>  Xaa is M, L, I or Y

<220>
<221>  Xaa
<222>  (961)..(961)
<223>  Xaa is L, I, V or M

<220>
<221>  Xaa
<222>  (962)..(962)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (963)..(963)
<223>  Xaa is Q

<220>
<221>  Xaa
<222>  (964)..(964)
<223>  Xaa is V or I

<220>
<221>  Xaa
<222>  (965)..(965)
<223>  Xaa is H

<220>
<221>  Xaa
<222>  (966)..(966)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (967)..(967)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (968)..(968)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (969)..(969)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (970)..(970)
<223>  Xaa is L, F, V or A

<220>
<221>  Xaa
<222>  (971)..(971)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (972)..(972)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (973)..(973)
<223>  Xaa is P, E, N, H, Y or R

<220>
<221>  Xaa
<222>  (974)..(974)
<223>  Xaa is K, Q, E, D, N, F or T

<220>
<221>  Xaa
<222>  (975)..(975)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (976)..(976)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (977)..(977)
<223>  Xaa is A, I , M, L, V or K

<220>
<221>  Xaa
<222>  (978)..(978)
<223>  Xaa is E, S, D, Q or A

<220>
<221>  Xaa
<222>  (979)..(979)
<223>  Xaa is A, E, K, F, D, I, R or Q

<220>
<221>  Xaa
<222>  (980)..(980)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (981)..(981)
<223>  Xaa is A, K, S, P, V or C

<220>
<221>  Xaa
<222>  (982)..(982)
<223>  Xaa is R, A, E, L, T, K, N, Q or I

<220>
<221>  Xaa
<222>  (983)..(983)
<223>  Xaa is L, I, M, K, Q or E

<220>
<221>  Xaa
<222>  (984)..(984)
<223>  Xaa is A, V, I, L or T

<220>
<221>  Xaa
<222>  (985)..(985)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (986)..(986)
<223>  Xaa is E, N, Q, D or R

<220>
<221>  Xaa
<222>  (987)..(987)
<223>  Xaa is V, A, E, K, I, L, S, R or N

<220>
<221>  Xaa
<222>  (988)..(988)
<223>  Xaa is M

<220>
<221>  Xaa
<222>  (989)..(989)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (990)..(990)
<223>  Xaa is G, K, N, Q or R

<220>
<221>  Xaa
<222>  (991)..(991)
<223>  Xaa is V, A, D, I, C or W

<220>
<221>  Xaa
<222>  (992)..(992)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (993)..(993)
<223>  Xaa is P, S, E, R, K, A, T, Q or G

<220>
<221>  Xaa
<222>  (994)..(994)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (995)..(995)
<223>  Xaa is R, D, S, K or H

<220>
<221>  Xaa
<222>  (996)..(996)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (997)..(997)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (998)..(998)
<223>  Xaa is G or F

<220>
<221>  Xaa
<222>  (999)..(999)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (1000)..(1000)
<223>  Xaa is C

<220>
<221>  Xaa
<222>  (1001)..(1001)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (1002)..(1002)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (1003)..(1003)
<223>  Xaa is E, V, T, L, K, P or D

<220>
<221>  Xaa
<222>  (1004)..(1004)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (1005)..(1005)
<223>  Xaa is E, N, D or G

<220>
<221>  Xaa
<222>  (1006)..(1006)
<223>  Xaa is V, I, L, Y or G

<220>
<221>  Xaa
<222>  (1007)..(1007)
<223>  Xaa is G, F, S, K, T, Y, H or D

<220>
<221>  Xaa
<222>  (1008)..(1008)
<223>  Xaa is I, M, V, S, T, I, E or Y

<220>
<221>  Xaa
<222>  (1009)..(1009)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (1010)..(1010)
<223>  Xaa is E, R, N, K, P, D or S

<220>
<221>  Xaa
<222>  (1011)..(1011)
<223>  Xaa is D, S, N, T or E

<220>
<221>  Xaa
<222>  (1012)..(1012)
<223>  Xaa is W

<220>
<221>  Xaa
<222>  (1013)..(1013)
<223>  Xaa is L, N, A, Y, D, E, S, F or G

<220>
<221>  Xaa
<222>  (1014)..(1014)
<223>  Xaa is S, E, I, L, D, Q or G

<220>
<221>  Xaa
<222>  (1015)..(1015)
<223>  Xaa is A, L, S or C

<220>
<221>  Xaa
<222>  (1016)..(1016)
<223>  Xaa is K, N, H or R

<220>
<221>  Xaa
<222>  (1017)..(1017)
<223>  Xaa is E, G, Q, P or D

<220>
<221>  Xaa
<222>  (1018)..(1018)
<223>  Xaa is D or Y

<220>
<221>  Xaa
<222>  (1019)..(1019)
<223>  Xaa is Q or S

<220>
<221>  Xaa
<222>  (1020)..(1020)
<223>  Xaa is S or C

<220>
<221>  Xaa
<222>  (1021)..(1021)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (1022)..(1022)
<223>  Xaa is E or K

<220>
<221>  Xaa
<222>  (1023)..(1023)
<223>  Xaa is M

<220>
<221>  Xaa
<222>  (1024)..(1024)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (1025)..(1025)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (1026)..(1026)
<223>  Xaa is Q

<220>
<221>  Xaa
<222>  (1027)..(1027)
<223>  Xaa is H

<220>
<221>  Xaa
<222>  (1028)..(1028)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (1029)..(1029)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (1030)..(1030)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (1031)..(1031)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (1032)..(1032)
<223>  Xaa is C

<220>
<221>  Xaa
<222>  (1033)..(1033)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (1034)..(1034)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (1035)..(1035)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (1036)..(1036)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (1037)..(1037)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (1038)..(1038)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (1039)..(1039)
<223>  Xaa is T

<220>
<221>  Xaa
<222>  (1040)..(1040)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (1041)..(1041)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (1042)..(1042)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (1043)..(1043)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (1044)..(1044)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (1045)..(1045)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (1046)..(1046)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (1047)..(1047)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (1048)..(1048)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (1049)..(1049)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (1050)..(1050)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (1051)..(1051)
<223>  Xaa is F

<220>
<221>  Xaa
<222>  (1052)..(1052)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (1053)..(1053)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (1054)..(1054)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (1055)..(1055)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (1056)..(1056)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (1057)..(1057)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (1058)..(1058)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (1059)..(1059)
<223>  Xaa is M

<220>
<221>  Xaa
<222>  (1060)..(1060)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (1061)..(1061)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (1062)..(1062)
<223>  Xaa is E

<220>
<221>  Xaa
<222>  (1063)..(1063)
<223>  Xaa is H

<220>
<221>  Xaa
<222>  (1064)..(1064)
<223>  Xaa is P

<220>
<221>  Xaa
<222>  (1065)..(1065)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (1066)..(1066)
<223>  Xaa is H

<220>
<221>  Xaa
<222>  (1067)..(1067)
<223>  Xaa is S

<220>
<221>  Xaa
<222>  (1068)..(1068)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (1069)..(1069)
<223>  Xaa is Y

<220>
<221>  Xaa
<222>  (1070)..(1070)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (1071)..(1071)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (1072)..(1072)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (1073)..(1073)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (1074)..(1074)
<223>  Xaa is F

<220>
<221>  Xaa
<222>  (1075)..(1075)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (1076)..(1076)
<223>  Xaa is A

<220>
<221>  Xaa
<222>  (1077)..(1077)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (1078)..(1078)
<223>  Xaa is C

<220>
<221>  Xaa
<222>  (1079)..(1079)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (1080)..(1080)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (1081)..(1081)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (1082)..(1082)
<223>  Xaa is D

<220>
<221>  Xaa
<222>  (1083)..(1083)
<223>  Xaa is N

<220>
<221>  Xaa
<222>  (1084)..(1084)
<223>  Xaa is V

<220>
<221>  Xaa
<222>  (1085)..(1085)
<223>  Xaa is K

<220>
<221>  Xaa
<222>  (1086)..(1086)
<223>  Xaa is R

<220>
<221>  Xaa
<222>  (1087)..(1087)
<223>  Xaa is I

<220>
<221>  Xaa
<222>  (1088)..(1088)
<223>  Xaa is L

<220>
<221>  Xaa
<222>  (1089)..(1089)
<223>  Xaa is G

<220>
<221>  Xaa
<222>  (1090)..(1090)
<223>  Xaa is A

<400>  19

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Asp Gly Xaa Xaa Leu Xaa Tyr 
            20                  25                  30          


Arg Ala Xaa Xaa Ala Leu Xaa Xaa Xaa Leu Xaa Thr Ser Xaa Gly Xaa 
        35                  40                  45              


Xaa Thr Asn Ala Xaa Tyr Gly Phe Xaa Xaa Met Leu Xaa Lys Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa Phe Asp 
65                  70                  75                  80  


Xaa Lys Xaa Xaa Thr Phe Xaa Arg His Xaa Xaa Xaa Xaa Xaa Tyr Lys 
                85                  90                  95      


Xaa Xaa Arg Xaa Xaa Xaa Pro Xaa Xaa Xaa Xaa Xaa Gln Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Glu Xaa Xaa 
        115                 120                 125             


Gly Tyr Glu Ala Asp Asp Ile Ile Xaa Thr Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Xaa Xaa Gly Asp Xaa Asp Xaa 
145                 150                 155                 160 


Xaa Gln Leu Val Xaa Xaa Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa 
                165                 170                 175     


Ile Thr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa Glu Lys Tyr 
            180                 185                 190         


Gly Val Xaa Pro Xaa Xaa Xaa Xaa Asp Xaa Xaa Xaa Leu Xaa Gly Xaa 
        195                 200                 205             


Xaa Ser Asp Asn Ile Pro Gly Val Xaa Gly Ile Gly Glu Lys Thr Ala 
    210                 215                 220                 


Xaa Xaa Leu Leu Xaa Xaa Xaa Gly Xaa Xaa Glu Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Leu Xaa Xaa Xaa Xaa Glu Xaa Xaa Xaa Leu Ser Xaa Xaa Leu 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Pro Xaa Xaa Xaa Glu Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Lys Leu Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Leu Glu Phe Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Gly Xaa Xaa Leu Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Phe Xaa Xaa Asp Xaa Xaa Xaa Xaa Ala Tyr Leu Leu Xaa Pro Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Asp Xaa Xaa Ala Xaa Xaa Tyr Leu Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala 
        515                 520                 525             


Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Glu Xaa Xaa Leu Xaa Xaa Leu Xaa Xaa Xaa Ile Glu 
545                 550                 555                 560 


Xaa Pro Leu Xaa Xaa Val Leu Xaa Xaa Met Glu Xaa Xaa Gly Xaa Xaa 
                565                 570                 575     


Xaa Asp Xaa Xaa Xaa Leu Lys Xaa Leu Ser Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Leu Xaa Xaa Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Ala Gly Xaa Xaa Phe Asn Xaa Asn Ser Xaa Lys Gln 
    610                 615                 620                 


Leu Xaa Xaa Xaa Leu Phe Xaa Xaa Leu Xaa Leu Pro Xaa Xaa Xaa Lys 
625                 630                 635                 640 


Thr Xaa Xaa Thr Gly Xaa Xaa Ser Thr Xaa Xaa Glu Val Leu Xaa Xaa 
                645                 650                 655     


Leu Xaa Xaa Xaa His Pro Xaa Xaa Xaa Ile Xaa Xaa Xaa Ile Leu Xaa 
            660                 665                 670         


Xaa Tyr Arg Xaa Leu Xaa Lys Leu Lys Ser Thr Tyr Xaa Asp Xaa Leu 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Pro Xaa Thr Gly Arg Xaa His Thr Xaa 
    690                 695                 700                 


Phe Asn Gln Thr Xaa Thr Ala Thr Gly Arg Leu Ser Ser Ser Xaa Pro 
705                 710                 715                 720 


Xaa Asn Leu Gln Xaa Ile Pro Xaa Xaa Arg Xaa Glu Xaa Gly Xaa Xaa 
                725                 730                 735     


Ile Arg Xaa Ala Phe Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Xaa Xaa 
            740                 745                 750         


Ala Asp Tyr Ser Gln Ile Glu Leu Arg Xaa Leu Ala Xaa His Leu Ser 
        755                 760                 765             


Xaa Asp Xaa Asn Leu Ile Xaa Ala Phe Xaa Xaa Gly Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Asp Ile His Thr Xaa Thr Ala Ser Xaa Ile Phe Xaa 
785                 790                 795                 800 


Val Xaa Xaa Glu Xaa Xaa Xaa Xaa Xaa Xaa Val Thr Xaa Xaa Met Arg 
                805                 810                 815     


Arg Xaa Ala Lys Xaa Val Asn Xaa Gly Ile Xaa Tyr Gly Xaa Ser Xaa 
            820                 825                 830         


Xaa Gly Leu Ser Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Xaa Xaa Xaa Glu Ala Xaa Xaa 
    850                 855                 860                 


Xaa Ile Glu Xaa Tyr Phe Xaa Xaa Xaa Pro Xaa Val Xaa Xaa Xaa Ile 
865                 870                 875                 880 


Xaa Xaa Xaa Xaa Xaa Xaa Ala Lys Xaa Xaa Gly Tyr Val Xaa Thr Leu 
                885                 890                 895     


Phe Gly Arg Arg Arg Xaa Xaa Pro Xaa Ile Xaa Ser Arg Asn Xaa Xaa 
            900                 905                 910         


Val Arg Xaa Xaa Xaa Glu Arg Xaa Ala Xaa Asn Xaa Pro Ile Gln Gly 
        915                 920                 925             


Thr Ala Ala Asp Ile Ile Lys Leu Ala Met Xaa Xaa Xaa Xaa Xaa Xaa 
    930                 935                 940                 


Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
945                 950                 955                 960 


Xaa Leu Gln Xaa His Asp Glu Leu Val Xaa Glu Val Xaa Xaa Glu Glu 
                965                 970                 975     


Xaa Xaa Xaa Val Xaa Xaa Xaa Xaa Lys Xaa Xaa Met Glu Xaa Xaa Val 
            980                 985                 990         


Xaa Leu Xaa Val Pro Xaa Xaa Xaa  Xaa Leu Xaa Val Xaa  Xaa Xaa Xaa 
        995                 1000                 1005             


Gly Xaa  Xaa Trp Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1010                 1015                 1020             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1025                 1030                 1035             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1040                 1045                 1050             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1055                 1060                 1065             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1070                 1075                 1080             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  
    1085                 1090 


<210>  20
<211>  1090
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence


<220>
<221>  X
<222>  (1)..(23)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (25)..(25)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (28)..(29)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (31)..(31)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (35)..(36)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (39)..(41)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (43)..(43)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (46)..(46)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (48)..(49)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (53)..(53)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (57)..(58)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (61)..(61)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (63)..(76)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (78)..(78)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (81)..(81)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (83)..(84)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (87)..(87)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (90)..(94)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (97)..(98)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (100)..(102)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (104)..(108)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (110)..(124)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (127)..(128)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (137)..(137)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (139)..(152)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (154)..(155)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (158)..(158)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (160)..(161)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (165)..(166)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (168)..(174)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (176)..(176)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (179)..(187)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (189)..(189)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (195)..(195)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (197)..(200)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (202)..(204)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (206)..(206)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (208)..(209)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (217)..(217)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (225)..(226)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (229)..(231)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (233)..(234)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (236)..(258)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (260)..(263)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (265)..(267)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (270)..(271)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (273)..(279)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (281)..(283)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (285)..(289)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (291)..(297)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (301)..(306)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (310)..(310)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (312)..(363)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (365)..(433)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (435)..(452)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (454)..(456)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (458)..(459)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (461)..(464)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (466)..(467)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (469)..(472)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (477)..(477)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (479)..(485)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (487)..(488)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (490)..(491)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (494)..(527)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (529)..(531)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (533)..(537)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (539)..(548)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (550)..(551)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (553)..(554)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (556)..(558)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (561)..(561)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (564)..(565)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (568)..(569)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (572)..(573)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (575)..(577)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (579)..(581)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (584)..(584)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (587)..(595)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (597)..(599)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (601)..(612)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (615)..(616)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (619)..(619)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (622)..(622)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (626)..(628)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (631)..(632)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (634)..(634)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (637)..(639)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (642)..(643)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (646)..(647)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (650)..(651)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (655)..(656)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (658)..(660)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (663)..(665)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (667)..(669)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (672)..(673)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (676)..(676)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (678)..(678)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (685)..(685)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (687)..(687)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (689)..(695)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (697)..(697)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (701)..(701)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (704)..(704)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (709)..(709)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (719)..(719)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (721)..(721)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (725)..(725)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (728)..(729)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (731)..(731)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (733)..(733)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (735)..(736)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (739)..(739)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (743)..(749)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (751)..(752)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (762)..(762)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (765)..(765)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (769)..(769)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (771)..(771)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (775)..(775)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (778)..(779)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (781)..(788)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (793)..(793)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (797)..(797)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (800)..(800)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (802)..(803)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (805)..(810)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (813)..(814)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (818)..(818)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (821)..(821)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (824)..(824)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (827)..(827)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (830)..(830)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (832)..(833)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (837)..(838)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (840)..(856)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (858)..(860)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (863)..(865)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (868)..(868)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (871)..(873)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (875)..(875)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (877)..(879)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (881)..(886)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (889)..(890)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (894)..(894)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (902)..(903)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (905)..(905)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (907)..(907)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (911)..(912)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (915)..(917)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (920)..(920)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (922)..(922)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (924)..(924)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (939)..(944)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (946)..(961)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (964)..(964)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (970)..(970)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (973)..(974)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (977)..(979)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (981)..(984)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (986)..(987)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (990)..(991)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (993)..(993)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (995)..(995)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (998)..(1001)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (1003)..(1003)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (1005)..(1008)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (1010)..(1011)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (1013)..(1090)
<223>  X is any amino acid or absent

<400>  20

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Asp Gly Xaa Xaa Leu Xaa Tyr 
            20                  25                  30          


Arg Ala Xaa Xaa Ala Leu Xaa Xaa Xaa Leu Xaa Thr Ser Xaa Gly Xaa 
        35                  40                  45              


Xaa Thr Asn Ala Xaa Tyr Gly Phe Xaa Xaa Met Leu Xaa Lys Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa Phe Asp 
65                  70                  75                  80  


Xaa Lys Xaa Xaa Thr Phe Xaa Arg His Xaa Xaa Xaa Xaa Xaa Tyr Lys 
                85                  90                  95      


Xaa Xaa Arg Xaa Xaa Xaa Pro Xaa Xaa Xaa Xaa Xaa Gln Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Glu Xaa Xaa 
        115                 120                 125             


Gly Tyr Glu Ala Asp Asp Ile Ile Xaa Thr Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Xaa Xaa Gly Asp Xaa Asp Xaa 
145                 150                 155                 160 


Xaa Gln Leu Val Xaa Xaa Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa 
                165                 170                 175     


Ile Thr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa Glu Lys Tyr 
            180                 185                 190         


Gly Val Xaa Pro Xaa Xaa Xaa Xaa Asp Xaa Xaa Xaa Leu Xaa Gly Xaa 
        195                 200                 205             


Xaa Ser Asp Asn Ile Pro Gly Val Xaa Gly Ile Gly Glu Lys Thr Ala 
    210                 215                 220                 


Xaa Xaa Leu Leu Xaa Xaa Xaa Gly Xaa Xaa Glu Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Leu Xaa Xaa Xaa Xaa Glu Xaa Xaa Xaa Leu Ser Xaa Xaa Leu 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Pro Xaa Xaa Xaa Glu Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Lys Leu Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Leu Glu Phe Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Gly Xaa Xaa Leu Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Phe Xaa Xaa Asp Xaa Xaa Xaa Xaa Ala Tyr Leu Leu Xaa Pro Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Asp Xaa Xaa Ala Xaa Xaa Tyr Leu Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala 
        515                 520                 525             


Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Glu Xaa Xaa Leu Xaa Xaa Leu Xaa Xaa Xaa Ile Glu 
545                 550                 555                 560 


Xaa Pro Leu Xaa Xaa Val Leu Xaa Xaa Met Glu Xaa Xaa Gly Xaa Xaa 
                565                 570                 575     


Xaa Asp Xaa Xaa Xaa Leu Lys Xaa Leu Ser Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Leu Xaa Xaa Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Ala Gly Xaa Xaa Phe Asn Xaa Asn Ser Xaa Lys Gln 
    610                 615                 620                 


Leu Xaa Xaa Xaa Leu Phe Xaa Xaa Leu Xaa Leu Pro Xaa Xaa Xaa Lys 
625                 630                 635                 640 


Thr Xaa Xaa Thr Gly Xaa Xaa Ser Thr Xaa Xaa Glu Val Leu Xaa Xaa 
                645                 650                 655     


Leu Xaa Xaa Xaa His Pro Xaa Xaa Xaa Ile Xaa Xaa Xaa Ile Leu Xaa 
            660                 665                 670         


Xaa Tyr Arg Xaa Leu Xaa Lys Leu Lys Ser Thr Tyr Xaa Asp Xaa Leu 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Pro Xaa Thr Gly Arg Xaa His Thr Xaa 
    690                 695                 700                 


Phe Asn Gln Thr Xaa Thr Ala Thr Gly Arg Leu Ser Ser Ser Xaa Pro 
705                 710                 715                 720 


Xaa Asn Leu Gln Xaa Ile Pro Xaa Xaa Arg Xaa Glu Xaa Gly Xaa Xaa 
                725                 730                 735     


Ile Arg Xaa Ala Phe Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Xaa Xaa 
            740                 745                 750         


Ala Asp Tyr Ser Gln Ile Glu Leu Arg Xaa Leu Ala Xaa His Leu Ser 
        755                 760                 765             


Xaa Asp Xaa Asn Leu Ile Xaa Ala Phe Xaa Xaa Gly Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Asp Ile His Thr Xaa Thr Ala Ser Xaa Ile Phe Xaa 
785                 790                 795                 800 


Val Xaa Xaa Glu Xaa Xaa Xaa Xaa Xaa Xaa Val Thr Xaa Xaa Met Arg 
                805                 810                 815     


Arg Xaa Ala Lys Xaa Val Asn Xaa Gly Ile Xaa Tyr Gly Xaa Ser Xaa 
            820                 825                 830         


Xaa Gly Leu Ser Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Xaa Xaa Xaa Glu Ala Xaa Xaa 
    850                 855                 860                 


Xaa Ile Glu Xaa Tyr Phe Xaa Xaa Xaa Pro Xaa Val Xaa Xaa Xaa Ile 
865                 870                 875                 880 


Xaa Xaa Xaa Xaa Xaa Xaa Ala Lys Xaa Xaa Gly Tyr Val Xaa Thr Leu 
                885                 890                 895     


Phe Gly Arg Arg Arg Xaa Xaa Pro Xaa Ile Xaa Ser Arg Asn Xaa Xaa 
            900                 905                 910         


Val Arg Xaa Xaa Xaa Glu Arg Xaa Ala Xaa Asn Xaa Pro Ile Gln Gly 
        915                 920                 925             


Thr Ala Ala Asp Ile Ile Lys Leu Ala Met Xaa Xaa Xaa Xaa Xaa Xaa 
    930                 935                 940                 


Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
945                 950                 955                 960 


Xaa Leu Gln Xaa His Asp Glu Leu Val Xaa Glu Val Xaa Xaa Glu Glu 
                965                 970                 975     


Xaa Xaa Xaa Val Xaa Xaa Xaa Xaa Lys Xaa Xaa Met Glu Xaa Xaa Val 
            980                 985                 990         


Xaa Leu Xaa Val Pro Xaa Xaa Xaa  Xaa Leu Xaa Val Xaa  Xaa Xaa Xaa 
        995                 1000                 1005             


Gly Xaa  Xaa Trp Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1010                 1015                 1020             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1025                 1030                 1035             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1040                 1045                 1050             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1055                 1060                 1065             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1070                 1075                 1080             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  
    1085                 1090 


<210>  21
<211>  989
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence


<220>
<221>  X
<222>  (2)..(2)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (5)..(6)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (8)..(8)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (12)..(13)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (16)..(18)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (20)..(20)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (23)..(23)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (25)..(26)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (30)..(30)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (34)..(35)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (38)..(38)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (40)..(53)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (55)..(55)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (58)..(58)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (60)..(61)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (64)..(64)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (67)..(71)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (74)..(75)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (77)..(79)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (81)..(85)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (87)..(101)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (104)..(105)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (114)..(114)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (116)..(129)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (131)..(132)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (135)..(135)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (137)..(138)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (142)..(143)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (145)..(151)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (153)..(153)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (156)..(164)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (166)..(166)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (172)..(172)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (174)..(177)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (179)..(181)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (183)..(183)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (185)..(186)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (194)..(194)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (202)..(203)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (206)..(208)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (210)..(211)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (213)..(235)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (237)..(240)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (242)..(244)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (247)..(248)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (250)..(256)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (258)..(260)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (262)..(266)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (268)..(274)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (278)..(283)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (287)..(287)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (289)..(340)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (342)..(410)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (412)..(429)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (431)..(433)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (435)..(436)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (438)..(441)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (443)..(444)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (446)..(449)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (454)..(454)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (456)..(462)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (464)..(465)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (467)..(468)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (471)..(504)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (506)..(508)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (510)..(514)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (516)..(525)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (527)..(528)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (530)..(531)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (533)..(535)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (538)..(538)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (541)..(542)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (545)..(546)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (549)..(550)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (552)..(554)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (556)..(558)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (561)..(561)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (564)..(572)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (574)..(576)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (578)..(589)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (592)..(593)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (596)..(596)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (599)..(599)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (603)..(605)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (608)..(609)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (611)..(611)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (614)..(616)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (619)..(620)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (623)..(624)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (627)..(628)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (632)..(633)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (635)..(637)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (640)..(642)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (644)..(646)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (649)..(650)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (653)..(653)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (655)..(655)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (662)..(662)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (664)..(664)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (666)..(672)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (674)..(674)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (678)..(678)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (681)..(681)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (686)..(686)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (696)..(696)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (698)..(698)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (702)..(702)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (705)..(706)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (708)..(708)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (710)..(710)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (712)..(713)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (716)..(716)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (720)..(726)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (728)..(729)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (739)..(739)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (742)..(742)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (746)..(746)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (748)..(748)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (752)..(752)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (755)..(756)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (758)..(765)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (770)..(770)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (774)..(774)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (777)..(777)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (779)..(780)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (782)..(787)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (790)..(791)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (795)..(795)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (798)..(798)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (801)..(801)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (804)..(804)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (807)..(807)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (809)..(810)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (814)..(815)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (817)..(833)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (835)..(837)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (840)..(842)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (845)..(845)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (848)..(850)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (852)..(852)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (854)..(856)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (858)..(863)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (866)..(867)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (871)..(871)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (879)..(880)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (882)..(882)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (884)..(884)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (888)..(889)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (892)..(894)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (897)..(897)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (899)..(899)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (901)..(901)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (916)..(921)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (923)..(938)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (941)..(941)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (947)..(947)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (950)..(951)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (954)..(956)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (958)..(961)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (963)..(964)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (967)..(968)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (970)..(970)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (972)..(972)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (975)..(978)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (980)..(980)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (982)..(985)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (987)..(988)
<223>  X is any amino acid or absent

<400>  21

Leu Xaa Asp Gly Xaa Xaa Leu Xaa Tyr Arg Ala Xaa Xaa Ala Leu Xaa 
1               5                   10                  15      


Xaa Xaa Leu Xaa Thr Ser Xaa Gly Xaa Xaa Thr Asn Ala Xaa Tyr Gly 
            20                  25                  30          


Phe Xaa Xaa Met Leu Xaa Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Val Xaa Phe Asp Xaa Lys Xaa Xaa Thr Phe Xaa 
    50                  55                  60                  


Arg His Xaa Xaa Xaa Xaa Xaa Tyr Lys Xaa Xaa Arg Xaa Xaa Xaa Pro 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Leu Glu Xaa Xaa Gly Tyr Glu Ala Asp Asp Ile 
            100                 105                 110         


Ile Xaa Thr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Ile Xaa Xaa Gly Asp Xaa Asp Xaa Xaa Gln Leu Val Xaa Xaa Lys 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Ile Thr Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Val Xaa Glu Lys Tyr Gly Val Xaa Pro Xaa Xaa Xaa 
                165                 170                 175     


Xaa Asp Xaa Xaa Xaa Leu Xaa Gly Xaa Xaa Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Xaa Gly Ile Gly Glu Lys Thr Ala Xaa Xaa Leu Leu Xaa Xaa Xaa 
        195                 200                 205             


Gly Xaa Xaa Glu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Glu Xaa Xaa Xaa Leu Ser Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Pro Xaa Xaa Xaa Glu Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Glu Lys Leu Xaa Xaa Xaa Xaa Xaa Xaa Leu Glu Phe Xaa Ser 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa 
            420                 425                 430         


Xaa Gly Xaa Xaa Leu Xaa Xaa Xaa Xaa Phe Xaa Xaa Asp Xaa Xaa Xaa 
        435                 440                 445             


Xaa Ala Tyr Leu Leu Xaa Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Xaa 
    450                 455                 460                 


Xaa Ala Xaa Xaa Tyr Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa Xaa Xaa Ala Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Xaa Xaa 
        515                 520                 525             


Leu Xaa Xaa Leu Xaa Xaa Xaa Ile Glu Xaa Pro Leu Xaa Xaa Val Leu 
    530                 535                 540                 


Xaa Xaa Met Glu Xaa Xaa Gly Xaa Xaa Xaa Asp Xaa Xaa Xaa Leu Lys 
545                 550                 555                 560 


Xaa Leu Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa 
                565                 570                 575     


Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Gly Xaa 
            580                 585                 590         


Xaa Phe Asn Xaa Asn Ser Xaa Lys Gln Leu Xaa Xaa Xaa Leu Phe Xaa 
        595                 600                 605             


Xaa Leu Xaa Leu Pro Xaa Xaa Xaa Lys Thr Xaa Xaa Thr Gly Xaa Xaa 
    610                 615                 620                 


Ser Thr Xaa Xaa Glu Val Leu Xaa Xaa Leu Xaa Xaa Xaa His Pro Xaa 
625                 630                 635                 640 


Xaa Xaa Ile Xaa Xaa Xaa Ile Leu Xaa Xaa Tyr Arg Xaa Leu Xaa Lys 
                645                 650                 655     


Leu Lys Ser Thr Tyr Xaa Asp Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Pro Xaa Thr Gly Arg Xaa His Thr Xaa Phe Asn Gln Thr Xaa Thr Ala 
        675                 680                 685             


Thr Gly Arg Leu Ser Ser Ser Xaa Pro Xaa Asn Leu Gln Xaa Ile Pro 
    690                 695                 700                 


Xaa Xaa Arg Xaa Glu Xaa Gly Xaa Xaa Ile Arg Xaa Ala Phe Val Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Ile Xaa Xaa Ala Asp Tyr Ser Gln Ile Glu 
                725                 730                 735     


Leu Arg Xaa Leu Ala Xaa His Leu Ser Xaa Asp Xaa Asn Leu Ile Xaa 
            740                 745                 750         


Ala Phe Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Ile His 
        755                 760                 765             


Thr Xaa Thr Ala Ser Xaa Ile Phe Xaa Val Xaa Xaa Glu Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Val Thr Xaa Xaa Met Arg Arg Xaa Ala Lys Xaa Val Asn 
785                 790                 795                 800 


Xaa Gly Ile Xaa Tyr Gly Xaa Ser Xaa Xaa Gly Leu Ser Xaa Xaa Leu 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Ile Xaa Xaa Xaa Glu Ala Xaa Xaa Xaa Ile Glu Xaa Tyr Phe Xaa 
        835                 840                 845             


Xaa Xaa Pro Xaa Val Xaa Xaa Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Ala 
    850                 855                 860                 


Lys Xaa Xaa Gly Tyr Val Xaa Thr Leu Phe Gly Arg Arg Arg Xaa Xaa 
865                 870                 875                 880 


Pro Xaa Ile Xaa Ser Arg Asn Xaa Xaa Val Arg Xaa Xaa Xaa Glu Arg 
                885                 890                 895     


Xaa Ala Xaa Asn Xaa Pro Ile Gln Gly Thr Ala Ala Asp Ile Ile Lys 
            900                 905                 910         


Leu Ala Met Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa 
        915                 920                 925             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Gln Xaa His Asp Glu 
    930                 935                 940                 


Leu Val Xaa Glu Val Xaa Xaa Glu Glu Xaa Xaa Xaa Val Xaa Xaa Xaa 
945                 950                 955                 960 


Xaa Lys Xaa Xaa Met Glu Xaa Xaa Val Xaa Leu Xaa Val Pro Xaa Xaa 
                965                 970                 975     


Xaa Xaa Leu Xaa Val Xaa Xaa Xaa Xaa Gly Xaa Xaa Trp 
            980                 985                 


<210>  22
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (5)..(6)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (12)..(13)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (16)..(18)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (20)..(20)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (23)..(23)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (25)..(26)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (30)..(30)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (34)..(35)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (38)..(38)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (40)..(53)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (55)..(55)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (58)..(58)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (60)..(61)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (64)..(64)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (67)..(71)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (74)..(75)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (77)..(79)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (81)..(85)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (87)..(101)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (104)..(105)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (114)..(114)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (116)..(129)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (131)..(132)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (135)..(135)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (137)..(138)
<223>  Xaa is any amino acid or absent

<220>
<221>  Xaa
<222>  (142)..(143)
<223>  Xaa is any amino acid or absent

<400>  22

Leu Xaa Asp Gly Xaa Xaa Leu Xaa Tyr Arg Ala Xaa Xaa Ala Leu Xaa 
1               5                   10                  15      


Xaa Xaa Leu Xaa Thr Ser Xaa Gly Xaa Xaa Thr Asn Ala Xaa Tyr Gly 
            20                  25                  30          


Phe Xaa Xaa Met Leu Xaa Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Val Xaa Phe Asp Xaa Lys Xaa Xaa Thr Phe Xaa 
    50                  55                  60                  


Arg His Xaa Xaa Xaa Xaa Xaa Tyr Lys Xaa Xaa Arg Xaa Xaa Xaa Pro 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Leu Glu Xaa Xaa Gly Tyr Glu Ala Asp Asp Ile 
            100                 105                 110         


Ile Xaa Thr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Ile Xaa Xaa Gly Asp Xaa Asp Xaa Xaa Gln Leu Val Xaa Xaa Lys 
    130                 135                 140                 


<210>  23
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence


<220>
<221>  X
<222>  (2)..(3)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (5)..(6)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (8)..(10)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (13)..(13)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (16)..(17)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (20)..(21)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (24)..(25)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (27)..(29)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (31)..(33)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (36)..(36)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (39)..(47)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (49)..(51)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (53)..(64)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (67)..(68)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (71)..(71)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (74)..(74)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (78)..(80)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (83)..(84)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (86)..(86)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (89)..(91)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (94)..(95)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (98)..(99)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (102)..(103)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (107)..(108)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (110)..(112)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (115)..(117)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (119)..(121)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (124)..(125)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (128)..(128)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (130)..(130)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (137)..(137)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (139)..(139)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (141)..(147)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (149)..(149)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (153)..(153)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (156)..(156)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (161)..(161)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (171)..(171)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (173)..(173)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (177)..(177)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (180)..(181)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (183)..(183)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (185)..(185)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (187)..(187)
<223>  X is any amino acid or absent

<220>
<221>  misc_feature
<222>  (188)..(188)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  X
<222>  (191)..(191)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (195)..(201)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (203)..(204)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (214)..(214)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (217)..(217)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (221)..(221)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (223)..(223)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (227)..(227)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (230)..(231)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (233)..(240)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (245)..(245)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (249)..(249)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (252)..(252)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (254)..(255)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (257)..(262)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (265)..(266)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (270)..(270)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (273)..(273)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (276)..(276)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (279)..(279)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (282)..(282)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (284)..(285)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (289)..(290)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (292)..(308)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (310)..(312)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (315)..(317)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (320)..(320)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (323)..(325)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (327)..(327)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (329)..(331)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (333)..(338)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (341)..(342)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (346)..(346)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (354)..(355)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (357)..(357)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (359)..(359)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (363)..(364)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (367)..(369)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (372)..(372)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (374)..(374)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (376)..(376)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (391)..(396)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (398)..(413)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (416)..(416)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (422)..(422)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (425)..(426)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (429)..(431)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (433)..(436)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (438)..(439)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (442)..(443)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (445)..(445)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (447)..(447)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (450)..(453)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (455)..(455)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (457)..(460)
<223>  X is any amino acid or absent

<220>
<221>  X
<222>  (462)..(463)
<223>  X is any amino acid or absent

<400>  23

Glu Xaa Xaa Leu Xaa Xaa Leu Xaa Xaa Xaa Ile Glu Xaa Pro Leu Xaa 
1               5                   10                  15      


Xaa Val Leu Xaa Xaa Met Glu Xaa Xaa Gly Xaa Xaa Xaa Asp Xaa Xaa 
            20                  25                  30          


Xaa Leu Lys Xaa Leu Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu 
        35                  40                  45              


Xaa Xaa Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Ala Gly Xaa Xaa Phe Asn Xaa Asn Ser Xaa Lys Gln Leu Xaa Xaa Xaa 
65                  70                  75                  80  


Leu Phe Xaa Xaa Leu Xaa Leu Pro Xaa Xaa Xaa Lys Thr Xaa Xaa Thr 
                85                  90                  95      


Gly Xaa Xaa Ser Thr Xaa Xaa Glu Val Leu Xaa Xaa Leu Xaa Xaa Xaa 
            100                 105                 110         


His Pro Xaa Xaa Xaa Ile Xaa Xaa Xaa Ile Leu Xaa Xaa Tyr Arg Xaa 
        115                 120                 125             


Leu Xaa Lys Leu Lys Ser Thr Tyr Xaa Asp Xaa Leu Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Pro Xaa Thr Gly Arg Xaa His Thr Xaa Phe Asn Gln Thr 
145                 150                 155                 160 


Xaa Thr Ala Thr Gly Arg Leu Ser Ser Ser Xaa Pro Xaa Asn Leu Gln 
                165                 170                 175     


Xaa Ile Pro Xaa Xaa Arg Xaa Glu Xaa Gly Xaa Xaa Ile Arg Xaa Ala 
            180                 185                 190         


Phe Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Xaa Xaa Ala Asp Tyr Ser 
        195                 200                 205             


Gln Ile Glu Leu Arg Xaa Leu Ala Xaa His Leu Ser Xaa Asp Xaa Asn 
    210                 215                 220                 


Leu Ile Xaa Ala Phe Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Asp Ile His Thr Xaa Thr Ala Ser Xaa Ile Phe Xaa Val Xaa Xaa Glu 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Val Thr Xaa Xaa Met Arg Arg Xaa Ala Lys 
            260                 265                 270         


Xaa Val Asn Xaa Gly Ile Xaa Tyr Gly Xaa Ser Xaa Xaa Gly Leu Ser 
        275                 280                 285             


Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Ile Xaa Xaa Xaa Glu Ala Xaa Xaa Xaa Ile Glu Xaa 
305                 310                 315                 320 


Tyr Phe Xaa Xaa Xaa Pro Xaa Val Xaa Xaa Xaa Ile Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Ala Lys Xaa Xaa Gly Tyr Val Xaa Thr Leu Phe Gly Arg Arg 
            340                 345                 350         


Arg Xaa Xaa Pro Xaa Ile Xaa Ser Arg Asn Xaa Xaa Val Arg Xaa Xaa 
        355                 360                 365             


Xaa Glu Arg Xaa Ala Xaa Asn Xaa Pro Ile Gln Gly Thr Ala Ala Asp 
    370                 375                 380                 


Ile Ile Lys Leu Ala Met Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Gln Xaa 
                405                 410                 415     


His Asp Glu Leu Val Xaa Glu Val Xaa Xaa Glu Glu Xaa Xaa Xaa Val 
            420                 425                 430         


Xaa Xaa Xaa Xaa Lys Xaa Xaa Met Glu Xaa Xaa Val Xaa Leu Xaa Val 
        435                 440                 445             


Pro Xaa Xaa Xaa Xaa Leu Xaa Val Xaa Xaa Xaa Xaa Gly Xaa Xaa Trp 
    450                 455                 460                 


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  24
gatcaacccc gctgccccac                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  25
cgaagcccat ccccgctcag                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  26
gcgcatgcaa gctgacctgg                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  27
tcacgctcca aggcgggaac                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  28
cctgctctgc cgcttcacgc                                                   20


<210>  29
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  29
gatgacgcat cctcacgata atatccgg                                          28


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  30
cctgctctgc cgcttcacgc                                                   20


<210>  31
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  31
gatgacgcat cctcacgata atatccgg                                          28


<210>  32
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  32
atgtcaccac aaacagagac taaag                                             25


<210>  33
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  33
tgcattacga tcggaacgcc ca                                                22


<210>  34
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  34
atgtcaccac aaacagagac taaag                                             25


<210>  35
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  35
tgcattacga tcggaacgcc ca                                                22


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  36
gatcaacccc gctgccccac                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  37
cgaagcccat ccccgctcag                                                   20


<210>  38
<211>  832
<212>  PRT
<213>  Thermus aquaticus

<400>  38

Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      


Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          


Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              


Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  


Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  


Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      


Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         


Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             


Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 


Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 


Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     


Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         


Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             


Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 


Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 


Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     


Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         


Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             


Glu Ser Pro Lys Ala Leu Glu Glu Ala Pro Trp Pro Pro Pro Glu Gly 
    290                 295                 300                 


Ala Phe Val Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp 
305                 310                 315                 320 


Leu Leu Ala Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro 
                325                 330                 335     


Glu Pro Tyr Lys Ala Leu Arg Asp Leu Lys Glu Ala Arg Gly Leu Leu 
            340                 345                 350         


Ala Lys Asp Leu Ser Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro 
        355                 360                 365             


Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn 
    370                 375                 380                 


Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu 
385                 390                 395                 400 


Glu Ala Gly Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asn Leu 
                405                 410                 415     


Trp Gly Arg Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu Tyr Arg Glu 
            420                 425                 430         


Val Glu Arg Pro Leu Ser Ala Val Leu Ala His Met Glu Ala Thr Gly 
        435                 440                 445             


Val Arg Leu Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala 
    450                 455                 460                 


Glu Glu Ile Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His 
465                 470                 475                 480 


Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp 
                485                 490                 495     


Glu Leu Gly Leu Pro Ala Ile Gly Lys Thr Glu Lys Thr Gly Lys Arg 
            500                 505                 510         


Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile 
        515                 520                 525             


Val Glu Lys Ile Leu Gln Tyr Arg Glu Leu Thr Lys Leu Lys Ser Thr 
    530                 535                 540                 


Tyr Ile Asp Pro Leu Pro Asp Leu Ile His Pro Arg Thr Gly Arg Leu 
545                 550                 555                 560 


His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser 
                565                 570                 575     


Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln 
            580                 585                 590         


Arg Ile Arg Arg Ala Phe Ile Ala Glu Glu Gly Trp Leu Leu Val Ala 
        595                 600                 605             


Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly 
    610                 615                 620                 


Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Arg Asp Ile His Thr 
625                 630                 635                 640 


Glu Thr Ala Ser Trp Met Phe Gly Val Pro Arg Glu Ala Val Asp Pro 
                645                 650                 655     


Leu Met Arg Arg Ala Ala Lys Thr Ile Asn Phe Gly Val Leu Tyr Gly 
            660                 665                 670         


Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr Glu Glu 
        675                 680                 685             


Ala Gln Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys Val Arg 
    690                 695                 700                 


Ala Trp Ile Glu Lys Thr Leu Glu Glu Gly Arg Arg Arg Gly Tyr Val 
705                 710                 715                 720 


Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Glu Ala Arg 
                725                 730                 735     


Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn Met Pro 
            740                 745                 750         


Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Lys Leu 
        755                 760                 765             


Phe Pro Arg Leu Glu Glu Met Gly Ala Arg Met Leu Leu Gln Val His 
    770                 775                 780                 


Asp Glu Leu Val Leu Glu Ala Pro Lys Glu Arg Ala Glu Ala Val Ala 
785                 790                 795                 800 


Arg Leu Ala Lys Glu Val Met Glu Gly Val Tyr Pro Leu Ala Val Pro 
                805                 810                 815     


Leu Glu Val Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Glu 
            820                 825                 830         


<210>  39
<211>  832
<212>  PRT
<213>  Thermus aquaticus

<400>  39

Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      


Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          


Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              


Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  


Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  


Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      


Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         


Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             


Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 


Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 


Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     


Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         


Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             


Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 


Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 


Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     


Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         


Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             


Glu Ser Pro Lys Ala Leu Glu Glu Ala Pro Trp Pro Pro Pro Glu Gly 
    290                 295                 300                 


Ala Phe Val Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp 
305                 310                 315                 320 


Leu Leu Ala Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro 
                325                 330                 335     


Glu Pro Tyr Lys Ala Leu Arg Asp Leu Lys Glu Ala Arg Gly Leu Leu 
            340                 345                 350         


Ala Lys Asp Leu Ser Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro 
        355                 360                 365             


Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn 
    370                 375                 380                 


Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu 
385                 390                 395                 400 


Glu Ala Gly Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asn Leu 
                405                 410                 415     


Trp Gly Arg Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu Tyr Arg Glu 
            420                 425                 430         


Val Glu Arg Pro Leu Ser Ala Val Leu Ala His Met Glu Ala Thr Gly 
        435                 440                 445             


Val Arg Leu Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala 
    450                 455                 460                 


Glu Glu Ile Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His 
465                 470                 475                 480 


Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp 
                485                 490                 495     


Glu Leu Gly Leu Pro Ala Ile Gly Lys Thr Lys Lys Thr Gly Lys Arg 
            500                 505                 510         


Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile 
        515                 520                 525             


Val Glu Lys Ile Leu Gln Tyr Arg Glu Leu Thr Lys Leu Lys Ser Thr 
    530                 535                 540                 


Tyr Ile Asp Pro Leu Pro Asp Leu Ile His Pro Arg Thr Gly Arg Leu 
545                 550                 555                 560 


His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser 
                565                 570                 575     


Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln 
            580                 585                 590         


Arg Ile Arg Arg Ala Phe Ile Ala Glu Glu Gly Trp Leu Leu Val Ala 
        595                 600                 605             


Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly 
    610                 615                 620                 


Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Arg Asp Ile His Thr 
625                 630                 635                 640 


Glu Thr Ala Ser Trp Met Phe Gly Val Pro Arg Glu Ala Val Asp Pro 
                645                 650                 655     


Leu Met Arg Arg Ala Ala Lys Thr Ile Asn Phe Gly Val Leu Tyr Gly 
            660                 665                 670         


Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr Glu Glu 
        675                 680                 685             


Ala Gln Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys Val Arg 
    690                 695                 700                 


Ala Trp Ile Glu Lys Thr Leu Glu Glu Gly Arg Arg Arg Gly Tyr Val 
705                 710                 715                 720 


Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Glu Ala Arg 
                725                 730                 735     


Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn Met Pro 
            740                 745                 750         


Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Lys Leu 
        755                 760                 765             


Phe Pro Arg Leu Glu Glu Met Gly Ala Arg Met Leu Leu Gln Val His 
    770                 775                 780                 


Asp Glu Leu Val Leu Glu Ala Pro Lys Glu Arg Ala Glu Ala Val Ala 
785                 790                 795                 800 


Arg Leu Ala Lys Glu Val Met Glu Gly Val Tyr Pro Leu Ala Val Pro 
                805                 810                 815     


Leu Glu Val Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Glu 
            820                 825                 830         


<210>  40
<211>  832
<212>  PRT
<213>  Thermus aquaticus

<400>  40

Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      


Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          


Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              


Lys Ser Leu Leu Asn Ala Leu Gln Asp Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  


Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  


Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      


Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         


Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             


Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 


Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 


Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     


Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         


Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             


Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 


Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 


Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     


Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         


Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             


Glu Ser Pro Lys Ala Leu Glu Glu Ala Pro Trp Pro Pro Pro Glu Gly 
    290                 295                 300                 


Ala Phe Val Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp 
305                 310                 315                 320 


Leu Leu Ala Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro 
                325                 330                 335     


Glu Pro Tyr Lys Ala Leu Arg Asp Leu Lys Glu Ala Arg Gly Leu Leu 
            340                 345                 350         


Ala Lys Asp Leu Ser Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro 
        355                 360                 365             


Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn 
    370                 375                 380                 


Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu 
385                 390                 395                 400 


Glu Ala Gly Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asn Leu 
                405                 410                 415     


Trp Gly Arg Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu Tyr Arg Glu 
            420                 425                 430         


Val Glu Arg Pro Leu Ser Ala Val Leu Ala His Met Glu Ala Thr Gly 
        435                 440                 445             


Val Arg Leu Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala 
    450                 455                 460                 


Glu Glu Ile Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His 
465                 470                 475                 480 


Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp 
                485                 490                 495     


Glu Leu Gly Leu Pro Ala Ile Gly Lys Thr Lys Lys Thr Gly Lys Arg 
            500                 505                 510         


Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile 
        515                 520                 525             


Val Glu Lys Ile Leu Gln Tyr Arg Glu Leu Thr Lys Leu Lys Ser Thr 
    530                 535                 540                 


Tyr Ile Asp Pro Leu Pro Asp Leu Ile His Pro Arg Thr Gly Arg Leu 
545                 550                 555                 560 


His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser 
                565                 570                 575     


Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln 
            580                 585                 590         


Arg Ile Arg Arg Ala Phe Ile Ala Glu Glu Gly Trp Leu Leu Val Ala 
        595                 600                 605             


Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly 
    610                 615                 620                 


Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Arg Asp Ile His Thr 
625                 630                 635                 640 


Glu Thr Ala Ser Trp Met Phe Gly Val Pro Arg Glu Ala Val Asp Pro 
                645                 650                 655     


Leu Met Arg Arg Ala Ala Lys Thr Ile Asn Phe Gly Val Leu Tyr Gly 
            660                 665                 670         


Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr Glu Glu 
        675                 680                 685             


Ala Gln Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys Val Arg 
    690                 695                 700                 


Ala Trp Ile Glu Lys Thr Leu Glu Glu Gly Arg Arg Arg Gly Tyr Val 
705                 710                 715                 720 


Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Glu Ala Arg 
                725                 730                 735     


Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn Met Pro 
            740                 745                 750         


Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Lys Leu 
        755                 760                 765             


Phe Pro Arg Leu Glu Glu Met Gly Ala Arg Met Leu Leu Gln Val His 
    770                 775                 780                 


Asp Glu Leu Val Leu Glu Ala Pro Lys Glu Arg Ala Glu Ala Val Ala 
785                 790                 795                 800 


Arg Leu Ala Lys Glu Val Met Glu Gly Val Tyr Pro Leu Ala Val Pro 
                805                 810                 815     


Leu Glu Val Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Glu 
            820                 825                 830         


<210>  41
<211>  834
<212>  PRT
<213>  Thermus thermophilus

<400>  41

Met Glu Ala Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      


Val Asp Gly His His Leu Ala Tyr Arg Thr Phe Phe Ala Leu Lys Gly 
            20                  25                  30          


Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              


Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Tyr Lys Ala Val Phe 
    50                  55                  60                  


Val Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Glu 
65                  70                  75                  80  


Ala Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln 
                85                  90                  95      


Leu Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Phe Thr Arg Leu 
            100                 105                 110         


Glu Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Thr Leu Ala Lys 
        115                 120                 125             


Lys Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Arg 
    130                 135                 140                 


Asp Leu Tyr Gln Leu Val Ser Asp Arg Val Ala Val Leu His Pro Glu 
145                 150                 155                 160 


Gly His Leu Ile Thr Pro Glu Trp Leu Trp Glu Lys Tyr Gly Leu Arg 
                165                 170                 175     


Pro Glu Gln Trp Val Asp Phe Arg Ala Leu Val Gly Asp Pro Ser Asp 
            180                 185                 190         


Asn Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Leu Lys Leu 
        195                 200                 205             


Leu Lys Glu Trp Gly Ser Leu Glu Asn Leu Leu Lys Asn Leu Asp Arg 
    210                 215                 220                 


Val Lys Pro Glu Asn Val Arg Glu Lys Ile Lys Ala His Leu Glu Asp 
225                 230                 235                 240 


Leu Arg Leu Ser Leu Glu Leu Ser Arg Val Arg Thr Asp Leu Pro Leu 
                245                 250                 255     


Glu Val Asp Leu Ala Gln Gly Arg Glu Pro Asp Arg Glu Gly Leu Arg 
            260                 265                 270         


Ala Phe Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly 
        275                 280                 285             


Leu Leu Glu Ala Pro Ala Pro Leu Glu Glu Ala Pro Trp Pro Pro Pro 
    290                 295                 300                 


Glu Gly Ala Phe Val Gly Phe Val Leu Ser Arg Pro Glu Pro Met Trp 
305                 310                 315                 320 


Ala Glu Leu Lys Ala Leu Ala Ala Cys Arg Asp Gly Arg Val His Arg 
                325                 330                 335     


Ala Ala Asp Pro Leu Ala Gly Leu Lys Asp Leu Lys Glu Val Arg Gly 
            340                 345                 350         


Leu Leu Ala Lys Asp Leu Ala Val Leu Ala Ser Arg Glu Gly Leu Asp 
        355                 360                 365             


Leu Val Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro 
    370                 375                 380                 


Ser Asn Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp 
385                 390                 395                 400 


Thr Glu Asp Ala Ala His Arg Ala Leu Leu Ser Glu Arg Leu His Arg 
                405                 410                 415     


Asn Leu Leu Lys Arg Leu Glu Gly Glu Glu Lys Leu Leu Trp Leu Tyr 
            420                 425                 430         


His Glu Val Glu Lys Pro Leu Ser Arg Val Leu Ala His Met Glu Ala 
        435                 440                 445             


Thr Gly Val Arg Leu Asp Val Ala Tyr Leu Gln Ala Leu Ser Leu Glu 
    450                 455                 460                 


Leu Ala Glu Glu Ile Arg Arg Leu Glu Glu Glu Val Phe Arg Leu Ala 
465                 470                 475                 480 


Gly His Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu 
                485                 490                 495     


Phe Asp Glu Leu Arg Leu Pro Ala Leu Gly Lys Thr Gln Lys Thr Gly 
            500                 505                 510         


Lys Arg Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His 
        515                 520                 525             


Pro Ile Val Glu Lys Ile Leu Gln His Arg Glu Leu Thr Lys Leu Lys 
    530                 535                 540                 


Asn Thr Tyr Val Asp Pro Leu Pro Ser Leu Val His Pro Arg Thr Gly 
545                 550                 555                 560 


Arg Leu His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu 
                565                 570                 575     


Ser Ser Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu 
            580                 585                 590         


Gly Gln Arg Ile Arg Arg Ala Phe Val Ala Glu Ala Gly Trp Ala Leu 
        595                 600                 605             


Val Ala Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu 
    610                 615                 620                 


Ser Gly Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Lys Asp Ile 
625                 630                 635                 640 


His Thr Gln Thr Ala Ser Trp Met Phe Gly Val Pro Pro Glu Ala Val 
                645                 650                 655     


Asp Pro Leu Met Arg Arg Ala Ala Lys Thr Val Asn Phe Gly Val Leu 
            660                 665                 670         


Tyr Gly Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr 
        675                 680                 685             


Glu Glu Ala Val Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys 
    690                 695                 700                 


Val Arg Ala Trp Ile Glu Lys Thr Leu Glu Glu Gly Arg Lys Arg Gly 
705                 710                 715                 720 


Tyr Val Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Asn 
                725                 730                 735     


Ala Arg Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn 
            740                 745                 750         


Met Pro Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val 
        755                 760                 765             


Lys Leu Phe Pro Arg Leu Arg Glu Met Gly Ala Arg Met Leu Leu Gln 
    770                 775                 780                 


Val His Asp Glu Leu Leu Leu Glu Ala Pro Gln Ala Arg Ala Glu Glu 
785                 790                 795                 800 


Val Ala Ala Leu Ala Lys Glu Ala Met Glu Lys Ala Tyr Pro Leu Ala 
                805                 810                 815     


Val Pro Leu Glu Val Glu Val Gly Met Gly Glu Asp Trp Leu Ser Ala 
            820                 825                 830         


Lys Gly 
        


<210>  42
<211>  834
<212>  PRT
<213>  Thermus thermophilus

<400>  42

Met Glu Ala Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      


Val Asp Gly His His Leu Ala Tyr Arg Thr Phe Phe Ala Leu Lys Gly 
            20                  25                  30          


Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              


Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Tyr Lys Thr Val Phe 
    50                  55                  60                  


Val Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Glu 
65                  70                  75                  80  


Ala Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln 
                85                  90                  95      


Leu Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Phe Thr Arg Leu 
            100                 105                 110         


Glu Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Thr Leu Ala Lys 
        115                 120                 125             


Lys Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Arg 
    130                 135                 140                 


Asp Leu Tyr Gln Leu Val Ser Asp Arg Val Ala Val Leu His Pro Glu 
145                 150                 155                 160 


Gly His Leu Ile Thr Pro Glu Trp Leu Trp Glu Lys Tyr Gly Leu Arg 
                165                 170                 175     


Pro Glu Gln Trp Val Asp Phe Arg Ala Leu Val Gly Asp Pro Ser Asp 
            180                 185                 190         


Asn Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Leu Lys Leu 
        195                 200                 205             


Leu Lys Glu Trp Gly Ser Leu Glu Asn Leu Leu Lys Asn Leu Asp Arg 
    210                 215                 220                 


Val Lys Pro Glu Asn Val Arg Glu Lys Ile Lys Ala His Leu Glu Asp 
225                 230                 235                 240 


Leu Arg Leu Ser Leu Glu Leu Ser Arg Val Arg Thr Asp Leu Pro Leu 
                245                 250                 255     


Glu Val Asp Leu Ala Gln Gly Arg Glu Pro Asp Arg Glu Gly Leu Arg 
            260                 265                 270         


Ala Phe Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly 
        275                 280                 285             


Leu Leu Glu Ala Pro Ala Pro Leu Glu Glu Ala Pro Trp Pro Pro Pro 
    290                 295                 300                 


Glu Gly Ala Phe Val Gly Phe Val Leu Ser Arg Pro Glu Pro Met Trp 
305                 310                 315                 320 


Ala Glu Leu Lys Ala Leu Ala Ala Cys Arg Asp Gly Arg Val His Arg 
                325                 330                 335     


Ala Ala Asp Pro Leu Ala Gly Leu Lys Asp Leu Glu Glu Val Arg Gly 
            340                 345                 350         


Leu Leu Ala Lys Asp Leu Cys Val Leu Ala Ser Arg Glu Gly Leu Asp 
        355                 360                 365             


Leu Val Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro 
    370                 375                 380                 


Ser Asn Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp 
385                 390                 395                 400 


Thr Glu Asp Ala Ala His Arg Ala Leu Leu Ser Glu Arg Leu His Arg 
                405                 410                 415     


Asn Leu Leu Lys Arg Leu Glu Gly Glu Glu Lys Leu Leu Trp Leu Tyr 
            420                 425                 430         


His Glu Val Glu Lys Pro Leu Ser Arg Val Leu Ala His Met Glu Ala 
        435                 440                 445             


Thr Gly Val Arg Leu Asp Val Ala Tyr Leu Gln Ala Leu Ser Leu Glu 
    450                 455                 460                 


Leu Ala Glu Glu Ile Arg Arg Leu Glu Glu Glu Val Phe Arg Leu Ala 
465                 470                 475                 480 


Gly His Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu 
                485                 490                 495     


Phe Asp Glu Leu Arg Leu Pro Ala Leu Gly Lys Thr Lys Lys Thr Gly 
            500                 505                 510         


Lys Arg Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His 
        515                 520                 525             


Pro Ile Val Glu Lys Ile Leu Gln His Arg Glu Leu Thr Lys Leu Lys 
    530                 535                 540                 


Asn Thr Tyr Val Asp Pro Leu Pro Ser Leu Val His Pro Arg Thr Gly 
545                 550                 555                 560 


Arg Leu His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu 
                565                 570                 575     


Ser Ser Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu 
            580                 585                 590         


Gly Gln Arg Ile Arg Arg Ala Phe Val Ala Glu Ala Gly Trp Ala Leu 
        595                 600                 605             


Val Ala Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu 
    610                 615                 620                 


Ser Gly Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Lys Asp Ile 
625                 630                 635                 640 


His Thr Gln Thr Ala Ser Trp Met Phe Gly Val Pro Pro Glu Ala Val 
                645                 650                 655     


Asp Pro Leu Met Arg Arg Ala Ala Lys Thr Val Asn Phe Gly Val Leu 
            660                 665                 670         


Tyr Gly Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr 
        675                 680                 685             


Glu Glu Ala Val Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys 
    690                 695                 700                 


Val Arg Ala Trp Met Glu Lys Thr Leu Glu Glu Gly Arg Lys Arg Gly 
705                 710                 715                 720 


Tyr Val Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Asn 
                725                 730                 735     


Ala Arg Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Ile Asn 
            740                 745                 750         


Met Pro Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val 
        755                 760                 765             


Lys Leu Phe Pro Arg Leu Arg Glu Met Gly Ala Arg Met Leu Leu Gln 
    770                 775                 780                 


Val His Asp Glu Leu Leu Leu Glu Ala Pro Gln Ala Arg Ala Glu Glu 
785                 790                 795                 800 


Val Ala Ala Leu Ala Lys Glu Ala Met Glu Lys Ala Tyr Pro Leu Ala 
                805                 810                 815     


Val Pro Leu Glu Val Glu Val Gly Met Gly Glu Asp Trp Leu Ser Ala 
            820                 825                 830         


Lys Gly 
        


<210>  43
<211>  877
<212>  PRT
<213>  Geobacillus stearothermophilus

<400>  43

Met Arg Leu Lys Lys Lys Leu Val Leu Ile Asp Gly Asn Ser Val Ala 
1               5                   10                  15      


Tyr Arg Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile 
            20                  25                  30          


His Thr Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu 
        35                  40                  45              


Ala Glu Glu Gln Pro Thr His Leu Leu Val Ala Phe Asp Ala Gly Lys 
    50                  55                  60                  


Thr Thr Phe Arg His Glu Thr Phe Gln Glu Tyr Lys Gly Gly Arg Gln 
65                  70                  75                  80  


Gln Thr Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu 
                85                  90                  95      


Leu Lys Thr Tyr Arg Ile Pro Ala Tyr Glu Leu Tyr Ile Tyr Glu Ala 
            100                 105                 110         


Asp Asp Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe 
        115                 120                 125             


Glu Val Lys Ile Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser 
    130                 135                 140                 


Arg His Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu 
145                 150                 155                 160 


Pro Tyr Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu 
                165                 170                 175     


Gln Ile Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile 
            180                 185                 190         


Pro Gly Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Lys 
        195                 200                 205             


Gln Phe Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Val Lys 
    210                 215                 220                 


Gly Glu Lys Val Lys Glu Lys Leu Arg Gln His Arg Asp Leu Ala Leu 
225                 230                 235                 240 


Leu Ser Lys Gln Leu Ala Ser Ile Cys Arg Asp Ala Pro Val Glu Leu 
                245                 250                 255     


Ser Leu Asp Ala Leu Val Tyr Glu Gly Gln Asp Arg Glu Lys Val Ile 
            260                 265                 270         


Ala Leu Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Ala 
        275                 280                 285             


Ala Pro Ala Ala Glu Gly Arg Lys Pro Leu Glu Glu Met Glu Phe Ala 
    290                 295                 300                 


Ile Val Asp Val Ile Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu 
305                 310                 315                 320 


Val Val Glu Val Met Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly 
                325                 330                 335     


Ile Ala Leu Val Asn Glu His Gly Arg Phe Phe Met Arg Pro Glu Thr 
            340                 345                 350         


Ala Leu Ala Asp Ser Gln Phe Leu Ala Trp Leu Ala Asp Glu Thr Lys 
        355                 360                 365             


Lys Lys Ser Met Phe Asp Ala Lys Arg Ala Val Val Ala Leu Lys Trp 
    370                 375                 380                 


Lys Gly Ile Asp Val Arg Gly Val Ala Phe Asp Leu Leu Leu Ala Ala 
385                 390                 395                 400 


Tyr Leu Leu Asn Pro Ala Gln Asp Ala Gly Asp Ile Ala Ala Val Ala 
                405                 410                 415     


Lys Met Lys Gln Tyr Glu Ala Val Arg Ser Asp Glu Ala Val Tyr Gly 
            420                 425                 430         


Lys Gly Val Lys Arg Ser Leu Pro Asp Glu Gln Thr Leu Ala Glu His 
        435                 440                 445             


Leu Val Arg Lys Ala Ala Ala Ile Trp Ala Leu Glu Gln Pro Phe Met 
    450                 455                 460                 


Asp Asp Leu Arg Asn Asn Glu Gln Asp Gln Leu Leu Thr Lys Leu Glu 
465                 470                 475                 480 


Gln Pro Leu Ala Ala Ile Leu Ala Glu Met Glu Phe Thr Gly Val Asn 
                485                 490                 495     


Val Asp Thr Lys Arg Leu Glu Gln Met Gly Ser Glu Leu Ala Glu Gln 
            500                 505                 510         


Leu Arg Ala Ile Glu Gln Arg Ile Tyr Glu His Ala Gly Gln Glu Phe 
        515                 520                 525             


Asn Ile Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu 
    530                 535                 540                 


Gln Leu Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala 
545                 550                 555                 560 


Asp Val Leu Glu Lys Leu Ala Pro His His Glu Ile Val Glu Asn Ile 
                565                 570                 575     


Leu His Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly 
            580                 585                 590         


Leu Leu Lys Val Val Arg Pro Asp Thr Gly Lys Val His Thr Met Phe 
        595                 600                 605             


Asn Gln Thr Leu Thr Gln Thr Gly Arg Leu Ser Ser Ala Glu Pro Asn 
    610                 615                 620                 


Leu Gln Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln 
625                 630                 635                 640 


Ala Phe Val Pro Ser Glu Pro Asp Trp Leu Ile Phe Ala Ala Asp Tyr 
                645                 650                 655     


Ser Gln Ile Glu Leu Arg Val Leu Ala His Ile Ala Asp Asp Asp Asn 
            660                 665                 670         


Leu Ile Glu Ala Phe Gln Arg Asp Leu Asp Ile His Thr Lys Thr Ala 
        675                 680                 685             


Met Asp Ile Phe His Val Ser Glu Glu Glu Val Thr Ala Asn Met Arg 
    690                 695                 700                 


Arg Gln Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Asp 
705                 710                 715                 720 


Tyr Gly Leu Ala Gln Asn Leu Asn Ile Thr Arg Lys Glu Ala Ala Glu 
                725                 730                 735     


Phe Ile Glu Arg Tyr Phe Ala Ser Phe Pro Gly Val Arg Arg Tyr Met 
            740                 745                 750         


Glu Asn Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu 
        755                 760                 765             


Leu His Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Asn 
    770                 775                 780                 


Val Arg Ser Phe Ala Glu Arg Thr Ala Met Asn Thr Pro Ile Gln Gly 
785                 790                 795                 800 


Ser Ala Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Ala Ala Arg 
                805                 810                 815     


Leu Lys Glu Glu Gln Leu Gln Ala Arg Leu Leu Leu Gln Val His Asp 
            820                 825                 830         


Glu Leu Ile Leu Glu Ala Pro Lys Glu Glu Ile Glu Arg Leu Cys Glu 
        835                 840                 845             


Leu Val Pro Glu Val Met Glu Gln Ala Val Ser Ser Val Pro Leu Lys 
    850                 855                 860                 


Val Asp Tyr His Tyr Gly Pro Thr Trp Tyr Asp Ala Lys 
865                 870                 875         


<210>  44
<211>  877
<212>  PRT
<213>  Bacillus stearothermophilus

<400>  44

Met Arg Leu Lys Lys Lys Leu Val Leu Ile Asp Gly Asn Ser Val Ala 
1               5                   10                  15      


Tyr Arg Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile 
            20                  25                  30          


His Thr Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu 
        35                  40                  45              


Ala Glu Glu Gln Pro Thr Thr Leu Leu Val Ala Phe Asp Ala Gly Lys 
    50                  55                  60                  


Thr Thr Phe Arg His Glu Thr Phe Gln Glu Tyr Lys Gly Gly Arg Gln 
65                  70                  75                  80  


Gln Thr Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu 
                85                  90                  95      


Leu Lys Thr Tyr Arg Ile Pro Ala Tyr Glu Leu Tyr Ile Tyr Glu Ala 
            100                 105                 110         


Asp Asp Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe 
        115                 120                 125             


Glu Val Lys Ile Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser 
    130                 135                 140                 


Arg His Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu 
145                 150                 155                 160 


Pro Tyr Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu 
                165                 170                 175     


Gln Ile Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile 
            180                 185                 190         


Pro Gly Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Lys 
        195                 200                 205             


Gln Phe Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Val Lys 
    210                 215                 220                 


Gly Glu Lys Val Lys Glu Lys Leu Arg Gln His Arg Asp Leu Ala Leu 
225                 230                 235                 240 


Leu Ser Lys Gln Leu Ala Ser Ile Cys Arg Asp Ala Pro Val Glu Leu 
                245                 250                 255     


Ser Leu Asp Ala Leu Val Tyr Glu Gly Gln Asp Arg Glu Lys Val Ile 
            260                 265                 270         


Ala Leu Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Ala 
        275                 280                 285             


Ala Pro Ala Ala Glu Gly Arg Lys Pro Leu Glu Glu Met Glu Phe Ala 
    290                 295                 300                 


Ile Val Asp Val Ile Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu 
305                 310                 315                 320 


Val Val Glu Val Met Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly 
                325                 330                 335     


Ile Ala Leu Val Asn Glu His Gly Arg Phe Phe Met Arg Pro Glu Thr 
            340                 345                 350         


Ala Leu Ala Asp Ser Gln Phe Leu Ala Trp Leu Ala Asp Glu Glu Lys 
        355                 360                 365             


Lys Lys Ser Met Phe Asp Ala Lys Arg Cys Val Val Ala Leu Lys Trp 
    370                 375                 380                 


Lys Gly Ile Asp Val Arg Gly Val Ala Phe Asp Leu Leu Leu Ala Ala 
385                 390                 395                 400 


Tyr Leu Leu Asn Pro Ala Gln Asp Ala Gly Asp Ile Ala Ala Val Ala 
                405                 410                 415     


Lys Met Lys Gln Tyr Glu Ala Val Arg Ser Asp Glu Ala Val Tyr Gly 
            420                 425                 430         


Lys Gly Val Lys Arg Ser Leu Pro Asp Glu Gln Thr Leu Ala Glu His 
        435                 440                 445             


Leu Val Arg Lys Ala Ala Ala Ile Trp Ala Leu Glu Gln Pro Phe Met 
    450                 455                 460                 


Asp Asp Leu Arg Asn Asn Glu Gln Asp Gln Leu Leu Thr Lys Leu Glu 
465                 470                 475                 480 


Gln Pro Leu Ala Ala Ile Leu Ala Glu Met Glu Phe Thr Gly Val Asn 
                485                 490                 495     


Val Asp Thr Lys Arg Leu Glu Gln Met Gly Ser Glu Leu Ala Glu Gln 
            500                 505                 510         


Leu Arg Ala Ile Glu Gln Arg Ile Tyr Glu His Ala Gly Gln Glu Phe 
        515                 520                 525             


Asn Ile Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu 
    530                 535                 540                 


Gln Leu Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala 
545                 550                 555                 560 


Asp Val Leu Glu Lys Leu Ala Pro His His Glu Ile Val Glu Asn Ile 
                565                 570                 575     


Leu His Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly 
            580                 585                 590         


Leu Leu Lys Val Val Arg Pro Asp Thr Gly Lys Val His Thr Met Phe 
        595                 600                 605             


Asn Gln Thr Leu Thr Gln Thr Gly Arg Leu Ser Ser Ala Glu Pro Asn 
    610                 615                 620                 


Leu Gln Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln 
625                 630                 635                 640 


Ala Phe Val Pro Ser Glu Pro Asp Trp Leu Ile Phe Ala Ala Asp Tyr 
                645                 650                 655     


Ser Gln Ile Glu Leu Arg Val Leu Ala His Ile Ala Asp Asp Asp Asn 
            660                 665                 670         


Leu Ile Glu Ala Phe Gln Arg Asp Leu Asp Ile His Thr Lys Thr Ala 
        675                 680                 685             


Met Asp Ile Phe His Val Ser Glu Glu Glu Val Thr Ala Asn Met Arg 
    690                 695                 700                 


Arg Gln Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Asp 
705                 710                 715                 720 


Tyr Gly Leu Ala Gln Asn Leu Asn Ile Thr Arg Lys Glu Ala Ala Glu 
                725                 730                 735     


Phe Ile Glu Arg Tyr Phe Ala Ser Phe Pro Gly Val Arg Arg Tyr Met 
            740                 745                 750         


Glu Asn Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu 
        755                 760                 765             


Leu His Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Asn 
    770                 775                 780                 


Val Arg Ser Phe Ala Glu Arg Thr Ala Ile Asn Thr Pro Ile Gln Gly 
785                 790                 795                 800 


Ser Ala Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Ala Ala Arg 
                805                 810                 815     


Leu Lys Glu Glu Gln Leu Gln Ala Arg Leu Leu Leu Gln Val His Asp 
            820                 825                 830         


Glu Leu Ile Leu Glu Ala Pro Lys Glu Glu Ile Glu Arg Leu Cys Glu 
        835                 840                 845             


Leu Val Pro Glu Val Met Glu Gln Ala Val Ser Ser Val Pro Leu Lys 
    850                 855                 860                 


Val Asp Tyr His Tyr Gly Pro Thr Trp Tyr Asp Ala Lys 
865                 870                 875         


<210>  45
<211>  928
<212>  PRT
<213>  Escherichia coli

<400>  45

Met Val Gln Ile Pro Gln Asn Pro Leu Ile Leu Val Asp Gly Ser Ser 
1               5                   10                  15      


Tyr Leu Tyr Arg Ala Tyr His Ala Phe Pro Pro Leu Thr Asn Ser Ala 
            20                  25                  30          


Gly Glu Pro Thr Gly Ala Met Tyr Gly Val Leu Asn Met Leu Arg Ser 
        35                  40                  45              


Leu Ile Met Gln Tyr Lys Pro Thr His Ala Ala Val Val Phe Asp Ala 
    50                  55                  60                  


Lys Gly Lys Thr Phe Arg Asp Glu Leu Phe Glu His Tyr Lys Ser His 
65                  70                  75                  80  


Arg Pro Pro Met Pro Asp Asp Leu Arg Ala Gln Ile Glu Pro Leu His 
                85                  90                  95      


Ala Met Val Lys Ala Met Gly Leu Pro Leu Leu Ala Val Ser Gly Val 
            100                 105                 110         


Glu Ala Asp Asp Val Ile Gly Thr Leu Ala Arg Glu Ala Glu Lys Ala 
        115                 120                 125             


Gly Arg Pro Val Leu Ile Ser Thr Gly Asp Lys Asp Met Ala Gln Leu 
    130                 135                 140                 


Val Thr Pro Asn Ile Thr Leu Ile Asn Thr Met Thr Asn Thr Ile Leu 
145                 150                 155                 160 


Gly Pro Glu Glu Val Val Asn Lys Tyr Gly Val Pro Pro Glu Leu Ile 
                165                 170                 175     


Ile Asp Phe Leu Ala Leu Met Gly Asp Ser Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Pro Gly Val Gly Glu Lys Thr Ala Gln Ala Leu Leu Gln Gly Leu 
        195                 200                 205             


Gly Gly Leu Asp Thr Leu Tyr Ala Glu Pro Glu Lys Ile Ala Gly Leu 
    210                 215                 220                 


Ser Phe Arg Gly Ala Lys Thr Met Ala Ala Lys Leu Glu Gln Asn Lys 
225                 230                 235                 240 


Glu Val Ala Tyr Leu Ser Tyr Gln Leu Ala Thr Ile Lys Thr Asp Val 
                245                 250                 255     


Glu Leu Glu Leu Thr Cys Glu Gln Leu Glu Val Gln Gln Pro Ala Ala 
            260                 265                 270         


Glu Glu Leu Leu Gly Leu Phe Lys Lys Tyr Glu Phe Lys Arg Trp Thr 
        275                 280                 285             


Ala Asp Val Glu Ala Gly Lys Trp Leu Gln Ala Lys Gly Ala Lys Pro 
    290                 295                 300                 


Ala Ala Lys Pro Gln Glu Thr Ser Val Ala Asp Glu Ala Pro Glu Val 
305                 310                 315                 320 


Thr Ala Thr Val Ile Ser Tyr Asp Asn Tyr Val Thr Ile Leu Asp Glu 
                325                 330                 335     


Glu Thr Leu Lys Ala Trp Ile Ala Lys Leu Glu Lys Ala Pro Val Phe 
            340                 345                 350         


Ala Phe Asp Thr Glu Thr Asp Ser Leu Asp Asn Ile Ser Ala Asn Leu 
        355                 360                 365             


Val Gly Leu Ser Phe Ala Ile Glu Pro Gly Val Ala Ala Tyr Ile Pro 
    370                 375                 380                 


Val Ala His Asp Tyr Leu Asp Ala Pro Asp Gln Ile Ser Arg Glu Arg 
385                 390                 395                 400 


Ala Leu Glu Leu Leu Lys Pro Leu Leu Glu Asp Glu Lys Ala Leu Lys 
                405                 410                 415     


Val Gly Gln Asn Leu Lys Tyr Asp Arg Gly Ile Leu Ala Asn Tyr Gly 
            420                 425                 430         


Ile Glu Leu Arg Gly Ile Ala Phe Asp Thr Met Leu Glu Ser Tyr Ile 
        435                 440                 445             


Leu Asn Ser Val Ala Gly Arg His Asp Met Asp Ser Leu Ala Glu Arg 
    450                 455                 460                 


Trp Leu Lys His Lys Thr Ile Thr Phe Glu Glu Ile Ala Gly Lys Gly 
465                 470                 475                 480 


Lys Asn Gln Leu Thr Phe Asn Gln Ile Ala Leu Glu Glu Ala Gly Arg 
                485                 490                 495     


Tyr Ala Ala Glu Asp Ala Asp Val Thr Leu Gln Leu His Leu Lys Met 
            500                 505                 510         


Trp Pro Asp Leu Gln Lys His Lys Gly Pro Leu Asn Val Phe Glu Asn 
        515                 520                 525             


Ile Glu Met Pro Leu Val Pro Val Leu Ser Arg Ile Glu Arg Asn Gly 
    530                 535                 540                 


Val Lys Ile Asp Pro Lys Val Leu His Asn His Ser Glu Glu Leu Thr 
545                 550                 555                 560 


Leu Arg Leu Ala Glu Leu Glu Lys Lys Ala His Glu Ile Ala Gly Glu 
                565                 570                 575     


Glu Phe Asn Leu Ser Ser Thr Lys Gln Leu Gln Thr Ile Leu Phe Glu 
            580                 585                 590         


Lys Gln Gly Ile Lys Pro Leu Lys Lys Thr Pro Gly Gly Ala Pro Ser 
        595                 600                 605             


Thr Ser Glu Glu Val Leu Glu Glu Leu Ala Leu Asp Tyr Pro Leu Pro 
    610                 615                 620                 


Lys Val Ile Leu Glu Tyr Arg Gly Leu Ala Lys Leu Lys Ser Thr Tyr 
625                 630                 635                 640 


Thr Asp Lys Leu Pro Leu Met Ile Asn Pro Lys Thr Gly Arg Val His 
                645                 650                 655     


Thr Ser Tyr His Gln Ala Val Thr Ala Thr Gly Arg Leu Ser Ser Thr 
            660                 665                 670         


Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Asn Glu Glu Gly Arg Arg 
        675                 680                 685             


Ile Arg Gln Ala Phe Ile Ala Pro Glu Asp Tyr Val Ile Val Ser Ala 
    690                 695                 700                 


Asp Tyr Ser Gln Ile Glu Leu Arg Ile Met Ala His Leu Ser Arg Asp 
705                 710                 715                 720 


Lys Gly Leu Leu Thr Ala Phe Ala Glu Gly Lys Asp Ile His Arg Ala 
                725                 730                 735     


Thr Ala Ala Glu Val Phe Gly Leu Pro Leu Glu Thr Val Thr Ser Glu 
            740                 745                 750         


Gln Arg Arg Ser Ala Lys Ala Ile Asn Phe Gly Leu Ile Tyr Gly Met 
        755                 760                 765             


Ser Ala Phe Gly Leu Ala Arg Gln Leu Asn Ile Pro Arg Lys Glu Ala 
    770                 775                 780                 


Gln Lys Tyr Met Asp Leu Tyr Phe Glu Arg Tyr Pro Gly Val Leu Gln 
785                 790                 795                 800 


Tyr Met Glu Arg Thr Arg Ala Gln Ala Lys Glu Gln Gly Tyr Val Glu 
                805                 810                 815     


Thr Leu Asp Gly Arg Arg Leu Tyr Leu Pro Asp Ile Lys Ser Ser Asn 
            820                 825                 830         


Gly Ala Arg Arg Ala Ala Ala Glu Arg Ala Ala Ile Asn Ala Pro Met 
        835                 840                 845             


Gln Gly Thr Ala Ala Asp Ile Ile Lys Arg Ala Met Ile Ala Val Asp 
    850                 855                 860                 


Ala Trp Leu Gln Ala Glu Gln Pro Arg Val Arg Met Ile Met Gln Val 
865                 870                 875                 880 


His Asp Glu Leu Val Phe Glu Val His Lys Asp Asp Val Asp Ala Val 
                885                 890                 895     


Ala Lys Gln Ile His Gln Leu Met Glu Asn Cys Thr Arg Leu Asp Val 
            900                 905                 910         


Pro Leu Leu Val Glu Val Gly Ser Gly Glu Asn Trp Asp Gln Ala His 
        915                 920                 925             


<210>  46
<211>  928
<212>  PRT
<213>  Escherichia coli

<400>  46

Met Val Gln Ile Pro Gln Asn Pro Leu Ile Leu Val Asp Gly Ser Ser 
1               5                   10                  15      


Tyr Leu Tyr Arg Ala Tyr His Ala Phe Pro Pro Leu Thr Asn Ser Ala 
            20                  25                  30          


Gly Glu Pro Thr Gly Ala Met Tyr Gly Val Leu Asn Met Leu Arg Ser 
        35                  40                  45              


Leu Ile Met Gln Tyr Lys Pro Thr Thr Ala Ala Val Val Phe Asp Ala 
    50                  55                  60                  


Lys Gly Lys Thr Phe Arg Asp Glu Leu Phe Glu His Tyr Lys Ser His 
65                  70                  75                  80  


Arg Pro Pro Met Pro Asp Asp Leu Arg Ala Gln Ile Glu Pro Leu His 
                85                  90                  95      


Ala Met Val Lys Ala Met Gly Leu Pro Leu Leu Ala Val Ser Gly Val 
            100                 105                 110         


Glu Ala Asp Asp Val Ile Gly Thr Leu Ala Arg Glu Ala Glu Lys Ala 
        115                 120                 125             


Gly Arg Pro Val Leu Ile Ser Thr Gly Asp Lys Asp Met Ala Gln Leu 
    130                 135                 140                 


Val Thr Pro Asn Ile Thr Leu Ile Asn Thr Met Thr Asn Thr Ile Leu 
145                 150                 155                 160 


Gly Pro Glu Glu Val Val Asn Lys Tyr Gly Val Pro Pro Glu Leu Ile 
                165                 170                 175     


Ile Asp Phe Leu Ala Leu Met Gly Asp Ser Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Pro Gly Val Gly Glu Lys Thr Ala Gln Ala Leu Leu Gln Gly Leu 
        195                 200                 205             


Gly Gly Leu Asp Thr Leu Tyr Ala Glu Pro Glu Lys Ile Ala Gly Leu 
    210                 215                 220                 


Ser Phe Arg Gly Ala Lys Thr Met Ala Ala Lys Leu Glu Gln Asn Lys 
225                 230                 235                 240 


Glu Val Ala Tyr Leu Ser Tyr Gln Leu Ala Thr Ile Lys Thr Asp Val 
                245                 250                 255     


Glu Leu Glu Leu Thr Cys Glu Gln Leu Glu Val Gln Gln Pro Ala Ala 
            260                 265                 270         


Glu Glu Leu Leu Gly Leu Phe Lys Lys Tyr Glu Phe Lys Arg Trp Thr 
        275                 280                 285             


Ala Asp Val Glu Ala Gly Lys Trp Leu Gln Ala Lys Gly Ala Lys Pro 
    290                 295                 300                 


Ala Ala Lys Pro Gln Glu Thr Ser Val Ala Asp Glu Ala Pro Glu Val 
305                 310                 315                 320 


Thr Ala Thr Val Ile Ser Tyr Asp Asn Tyr Val Thr Ile Leu Asp Glu 
                325                 330                 335     


Glu Thr Leu Lys Ala Trp Ile Ala Lys Leu Glu Lys Ala Pro Val Phe 
            340                 345                 350         


Ala Phe Asp Thr Glu Thr Asp Ser Leu Asp Asn Ile Ser Ala Asn Leu 
        355                 360                 365             


Val Gly Leu Ser Phe Ala Ile Glu Pro Gly Val Ala Ala Tyr Ile Pro 
    370                 375                 380                 


Val Ala His Asp Tyr Leu Asp Ala Pro Asp Gln Ile Ser Arg Glu Arg 
385                 390                 395                 400 


Ala Leu Glu Leu Leu Lys Pro Leu Leu Glu Asp Glu Lys Cys Leu Lys 
                405                 410                 415     


Val Gly Gln Asn Leu Lys Tyr Asp Arg Gly Ile Leu Ala Asn Tyr Gly 
            420                 425                 430         


Ile Glu Leu Arg Gly Ile Ala Phe Asp Thr Met Leu Glu Ser Tyr Ile 
        435                 440                 445             


Leu Asn Ser Val Ala Gly Arg His Asp Met Asp Ser Leu Ala Glu Arg 
    450                 455                 460                 


Trp Leu Lys His Lys Thr Ile Thr Phe Glu Glu Ile Ala Gly Lys Gly 
465                 470                 475                 480 


Lys Asn Gln Leu Thr Phe Asn Gln Ile Ala Leu Glu Glu Ala Gly Arg 
                485                 490                 495     


Tyr Ala Ala Glu Asp Ala Asp Val Thr Leu Gln Leu His Leu Lys Met 
            500                 505                 510         


Trp Pro Asp Leu Gln Lys His Lys Gly Pro Leu Asn Val Phe Glu Asn 
        515                 520                 525             


Ile Glu Met Pro Leu Val Pro Val Leu Ser Arg Ile Glu Arg Asn Gly 
    530                 535                 540                 


Val Lys Ile Asp Pro Lys Val Leu His Asn His Ser Glu Glu Leu Thr 
545                 550                 555                 560 


Leu Arg Leu Ala Glu Leu Glu Lys Lys Ala His Glu Ile Ala Gly Glu 
                565                 570                 575     


Glu Phe Asn Leu Ser Ser Thr Lys Gln Leu Gln Thr Ile Leu Phe Glu 
            580                 585                 590         


Lys Gln Gly Ile Lys Pro Leu Lys Lys Thr Lys Gly Gly Ala Pro Ser 
        595                 600                 605             


Thr Ser Glu Glu Val Leu Glu Glu Leu Ala Leu Asp Tyr Pro Leu Pro 
    610                 615                 620                 


Lys Val Ile Leu Glu Tyr Arg Gly Leu Ala Lys Leu Lys Ser Thr Tyr 
625                 630                 635                 640 


Thr Asp Lys Leu Pro Leu Met Ile Asn Pro Lys Thr Gly Arg Val His 
                645                 650                 655     


Thr Ser Tyr His Gln Ala Val Thr Ala Thr Gly Arg Leu Ser Ser Thr 
            660                 665                 670         


Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Asn Glu Glu Gly Arg Arg 
        675                 680                 685             


Ile Arg Gln Ala Phe Ile Ala Pro Glu Asp Tyr Val Ile Val Ser Ala 
    690                 695                 700                 


Asp Tyr Ser Gln Ile Glu Leu Arg Ile Met Ala His Leu Ser Arg Asp 
705                 710                 715                 720 


Lys Gly Leu Leu Thr Ala Phe Ala Glu Gly Lys Asp Ile His Arg Ala 
                725                 730                 735     


Thr Ala Ala Glu Val Phe Gly Leu Pro Leu Glu Thr Val Thr Ser Glu 
            740                 745                 750         


Gln Arg Arg Ser Ala Lys Ala Ile Asn Phe Gly Leu Ile Tyr Gly Met 
        755                 760                 765             


Ser Ala Phe Gly Leu Ala Arg Gln Leu Asn Ile Pro Arg Lys Glu Ala 
    770                 775                 780                 


Gln Lys Tyr Met Asp Leu Tyr Phe Glu Arg Tyr Pro Gly Val Leu Gln 
785                 790                 795                 800 


Tyr Met Glu Arg Thr Arg Ala Gln Ala Lys Glu Gln Gly Tyr Val Glu 
                805                 810                 815     


Thr Leu Asp Gly Arg Arg Leu Tyr Leu Pro Asp Ile Lys Ser Ser Asn 
            820                 825                 830         


Gly Ala Arg Arg Ala Ala Ala Glu Arg Ala Ala Ile Asn Ala Pro Met 
        835                 840                 845             


Gln Gly Thr Ala Ala Asp Ile Ile Lys Arg Ala Met Ile Ala Val Asp 
    850                 855                 860                 


Ala Trp Leu Gln Ala Glu Gln Pro Arg Val Arg Met Ile Met Gln Val 
865                 870                 875                 880 


His Asp Glu Leu Val Phe Glu Val His Lys Asp Asp Val Asp Ala Val 
                885                 890                 895     


Ala Lys Gln Ile His Gln Leu Met Glu Asn Cys Thr Arg Leu Asp Val 
            900                 905                 910         


Pro Leu Leu Val Glu Val Gly Ser Gly Glu Asn Trp Asp Gln Ala His 
        915                 920                 925             


<210>  47
<211>  832
<212>  PRT
<213>  Unknown

<220>
<223>  Unknown

<400>  47

Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      


Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          


Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              


Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Thr Val Ile Val 
    50                  55                  60                  


Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  


Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      


Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         


Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             


Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 


Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 


Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     


Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         


Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             


Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 


Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 


Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     


Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         


Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             


Glu Ser Pro Lys Ala Leu Glu Glu Ala Pro Trp Pro Pro Pro Glu Gly 
    290                 295                 300                 


Ala Phe Val Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp 
305                 310                 315                 320 


Leu Leu Ala Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro 
                325                 330                 335     


Glu Pro Tyr Lys Ala Leu Arg Asp Leu Glu Glu Ala Arg Gly Leu Leu 
            340                 345                 350         


Ala Lys Asp Leu Cys Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro 
        355                 360                 365             


Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn 
    370                 375                 380                 


Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu 
385                 390                 395                 400 


Glu Ala Gly Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asn Leu 
                405                 410                 415     


Trp Gly Arg Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu Tyr Arg Glu 
            420                 425                 430         


Val Glu Arg Pro Leu Ser Ala Val Leu Ala His Met Glu Ala Thr Gly 
        435                 440                 445             


Val Arg Leu Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala 
    450                 455                 460                 


Glu Glu Ile Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His 
465                 470                 475                 480 


Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp 
                485                 490                 495     


Glu Leu Gly Leu Pro Ala Ile Gly Lys Thr Lys Lys Thr Gly Lys Arg 
            500                 505                 510         


Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile 
        515                 520                 525             


Val Glu Lys Ile Leu Gln Tyr Arg Glu Leu Thr Lys Leu Lys Ser Thr 
    530                 535                 540                 


Tyr Ile Asp Pro Leu Pro Asp Leu Ile His Pro Arg Thr Gly Arg Leu 
545                 550                 555                 560 


His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser 
                565                 570                 575     


Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln 
            580                 585                 590         


Arg Ile Arg Arg Ala Phe Ile Ala Glu Glu Gly Trp Leu Leu Val Ala 
        595                 600                 605             


Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly 
    610                 615                 620                 


Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Arg Asp Ile His Thr 
625                 630                 635                 640 


Glu Thr Ala Ser Trp Met Phe Gly Val Pro Arg Glu Ala Val Asp Pro 
                645                 650                 655     


Leu Met Arg Arg Ala Ala Lys Thr Ile Asn Phe Gly Val Leu Tyr Gly 
            660                 665                 670         


Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr Glu Glu 
        675                 680                 685             


Ala Gln Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys Val Arg 
    690                 695                 700                 


Ala Trp Met Glu Lys Thr Leu Glu Glu Gly Arg Arg Arg Gly Tyr Val 
705                 710                 715                 720 


Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Glu Ala Arg 
                725                 730                 735     


Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Ile Asn Met Pro 
            740                 745                 750         


Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Lys Leu 
        755                 760                 765             


Phe Pro Arg Leu Glu Glu Met Gly Ala Arg Met Leu Leu Gln Val His 
    770                 775                 780                 


Asp Glu Leu Val Leu Glu Ala Pro Lys Glu Arg Ala Glu Ala Val Ala 
785                 790                 795                 800 


Arg Leu Ala Lys Glu Val Met Glu Gly Val Tyr Pro Leu Ala Val Pro 
                805                 810                 815     


Leu Glu Val Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Glu 
            820                 825                 830         


<210>  48
<211>  832
<212>  PRT
<213>  Unknown

<220>
<223>  Unknown

<400>  48

Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      


Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          


Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              


Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Thr Val Ile Val 
    50                  55                  60                  


Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  


Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      


Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         


Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             


Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 


Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 


Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     


Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         


Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             


Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 


Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 


Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     


Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         


Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             


Glu Ser Pro Lys Ala Leu Glu Glu Ala Pro Trp Pro Pro Pro Glu Gly 
    290                 295                 300                 


Ala Phe Val Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp 
305                 310                 315                 320 


Leu Leu Ala Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro 
                325                 330                 335     


Glu Pro Tyr Lys Ala Leu Arg Asp Leu Glu Glu Ala Arg Gly Leu Leu 
            340                 345                 350         


Ala Lys Asp Leu Cys Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro 
        355                 360                 365             


Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn 
    370                 375                 380                 


Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu 
385                 390                 395                 400 


Glu Ala Gly Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asn Leu 
                405                 410                 415     


Trp Gly Arg Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu Tyr Arg Glu 
            420                 425                 430         


Val Glu Arg Pro Leu Ser Ala Val Leu Ala His Met Glu Ala Thr Gly 
        435                 440                 445             


Val Arg Leu Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala 
    450                 455                 460                 


Glu Glu Ile Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His 
465                 470                 475                 480 


Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp 
                485                 490                 495     


Glu Leu Gly Leu Pro Ala Ile Gly Lys Thr Lys Lys Thr Gly Lys Arg 
            500                 505                 510         


Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile 
        515                 520                 525             


Val Glu Lys Ile Leu Gln Tyr Arg Glu Leu Thr Lys Leu Lys Ser Thr 
    530                 535                 540                 


Tyr Ile Asp Pro Leu Pro Asp Leu Ile His Pro Arg Thr Gly Arg Leu 
545                 550                 555                 560 


His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser 
                565                 570                 575     


Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln 
            580                 585                 590         


Arg Ile Arg Arg Ala Phe Ile Ala Glu Glu Gly Trp Leu Leu Val Ala 
        595                 600                 605             


Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly 
    610                 615                 620                 


Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Arg Asp Ile His Thr 
625                 630                 635                 640 


Glu Thr Ala Ser Trp Met Phe Gly Val Pro Arg Glu Ala Val Asp Pro 
                645                 650                 655     


Leu Met Arg Arg Ala Ala Lys Thr Ile Asn Phe Gly Val Leu Tyr Gly 
            660                 665                 670         


Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr Glu Glu 
        675                 680                 685             


Ala Gln Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys Val Arg 
    690                 695                 700                 


Ala Trp Met Glu Lys Thr Leu Glu Glu Gly Arg Arg Arg Gly Tyr Val 
705                 710                 715                 720 


Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Glu Ala Arg 
                725                 730                 735     


Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Leu Asn Met Pro 
            740                 745                 750         


Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Lys Leu 
        755                 760                 765             


Phe Pro Arg Leu Glu Glu Met Gly Ala Arg Met Leu Leu Gln Val His 
    770                 775                 780                 


Asp Glu Leu Val Leu Glu Ala Pro Lys Glu Arg Ala Glu Ala Val Ala 
785                 790                 795                 800 


Arg Leu Ala Lys Glu Val Met Glu Gly Val Tyr Pro Leu Ala Val Pro 
                805                 810                 815     


Leu Glu Val Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Glu 
            820                 825                 830         


<210>  49
<211>  832
<212>  PRT
<213>  Thermus aquaticus

<400>  49

Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      


Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          


Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              


Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  


Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  


Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      


Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         


Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             


Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 


Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 


Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     


Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         


Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             


Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 


Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 


Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     


Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         


Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             


Glu Ser Pro Lys Ala Leu Glu Glu Ala Pro Trp Pro Pro Pro Glu Gly 
    290                 295                 300                 


Ala Phe Val Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp 
305                 310                 315                 320 


Leu Leu Ala Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro 
                325                 330                 335     


Glu Pro Tyr Lys Ala Leu Arg Asp Leu Lys Glu Ala Arg Gly Leu Leu 
            340                 345                 350         


Ala Lys Asp Leu Ser Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro 
        355                 360                 365             


Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn 
    370                 375                 380                 


Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu 
385                 390                 395                 400 


Glu Ala Gly Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asn Leu 
                405                 410                 415     


Trp Gly Arg Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu Tyr Arg Glu 
            420                 425                 430         


Val Glu Arg Pro Leu Ser Ala Val Leu Ala His Met Glu Ala Thr Gly 
        435                 440                 445             


Val Arg Leu Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala 
    450                 455                 460                 


Glu Glu Ile Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His 
465                 470                 475                 480 


Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp 
                485                 490                 495     


Glu Leu Gly Leu Pro Ala Ile Gly Lys Thr Glu Lys Thr Gly Lys Arg 
            500                 505                 510         


Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile 
        515                 520                 525             


Val Glu Lys Ile Leu Gln Tyr Arg Glu Leu Thr Lys Leu Lys Ser Thr 
    530                 535                 540                 


Tyr Ile Asp Pro Leu Pro Asp Leu Ile His Pro Arg Thr Gly Arg Leu 
545                 550                 555                 560 


His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser 
                565                 570                 575     


Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln 
            580                 585                 590         


Arg Ile Arg Arg Ala Phe Ile Ala Glu Glu Gly Trp Leu Leu Val Ala 
        595                 600                 605             


Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly 
    610                 615                 620                 


Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Arg Asp Ile His Thr 
625                 630                 635                 640 


Glu Thr Ala Ser Trp Met Phe Gly Val Pro Arg Glu Ala Val Asp Pro 
                645                 650                 655     


Leu Met Arg Arg Ala Ala Lys Thr Ile Asn Phe Gly Val Leu Tyr Gly 
            660                 665                 670         


Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr Glu Glu 
        675                 680                 685             


Ala Gln Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys Val Arg 
    690                 695                 700                 


Ala Trp Ile Glu Lys Thr Leu Glu Glu Gly Arg Arg Arg Gly Tyr Val 
705                 710                 715                 720 


Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Glu Ala Arg 
                725                 730                 735     


Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn Met Pro 
            740                 745                 750         


Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Lys Leu 
        755                 760                 765             


Phe Pro Arg Leu Glu Glu Met Gly Ala Arg Met Leu Leu Gln Val His 
    770                 775                 780                 


Asp Glu Leu Val Leu Glu Ala Pro Lys Glu Arg Ala Glu Ala Val Ala 
785                 790                 795                 800 


Arg Leu Ala Lys Glu Val Met Glu Gly Val Tyr Pro Leu Ala Val Pro 
                805                 810                 815     


Leu Glu Val Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Glu 
            820                 825                 830         


<210>  50
<211>  834
<212>  PRT
<213>  Thermus thermophilus

<400>  50

Met Glu Ala Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      


Val Asp Gly His His Leu Ala Tyr Arg Thr Phe Phe Ala Leu Lys Gly 
            20                  25                  30          


Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              


Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Tyr Lys Ala Val Phe 
    50                  55                  60                  


Val Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Glu 
65                  70                  75                  80  


Ala Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln 
                85                  90                  95      


Leu Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Phe Thr Arg Leu 
            100                 105                 110         


Glu Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Thr Leu Ala Lys 
        115                 120                 125             


Lys Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Arg 
    130                 135                 140                 


Asp Leu Tyr Gln Leu Val Ser Asp Arg Val Ala Val Leu His Pro Glu 
145                 150                 155                 160 


Gly His Leu Ile Thr Pro Glu Trp Leu Trp Glu Lys Tyr Gly Leu Arg 
                165                 170                 175     


Pro Glu Gln Trp Val Asp Phe Arg Ala Leu Val Gly Asp Pro Ser Asp 
            180                 185                 190         


Asn Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Leu Lys Leu 
        195                 200                 205             


Leu Lys Glu Trp Gly Ser Leu Glu Asn Leu Leu Lys Asn Leu Asp Arg 
    210                 215                 220                 


Val Lys Pro Glu Asn Val Arg Glu Lys Ile Lys Ala His Leu Glu Asp 
225                 230                 235                 240 


Leu Arg Leu Ser Leu Glu Leu Ser Arg Val Arg Thr Asp Leu Pro Leu 
                245                 250                 255     


Glu Val Asp Leu Ala Gln Gly Arg Glu Pro Asp Arg Glu Gly Leu Arg 
            260                 265                 270         


Ala Phe Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly 
        275                 280                 285             


Leu Leu Glu Ala Pro Ala Pro Leu Glu Glu Ala Pro Trp Pro Pro Pro 
    290                 295                 300                 


Glu Gly Ala Phe Val Gly Phe Val Leu Ser Arg Pro Glu Pro Met Trp 
305                 310                 315                 320 


Ala Glu Leu Lys Ala Leu Ala Ala Cys Arg Asp Gly Arg Val His Arg 
                325                 330                 335     


Ala Ala Asp Pro Leu Ala Gly Leu Lys Asp Leu Lys Glu Val Arg Gly 
            340                 345                 350         


Leu Leu Ala Lys Asp Leu Ala Val Leu Ala Ser Arg Glu Gly Leu Asp 
        355                 360                 365             


Leu Val Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro 
    370                 375                 380                 


Ser Asn Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp 
385                 390                 395                 400 


Thr Glu Asp Ala Ala His Arg Ala Leu Leu Ser Glu Arg Leu His Arg 
                405                 410                 415     


Asn Leu Leu Lys Arg Leu Glu Gly Glu Glu Lys Leu Leu Trp Leu Tyr 
            420                 425                 430         


His Glu Val Glu Lys Pro Leu Ser Arg Val Leu Ala His Met Glu Ala 
        435                 440                 445             


Thr Gly Val Arg Leu Asp Val Ala Tyr Leu Gln Ala Leu Ser Leu Glu 
    450                 455                 460                 


Leu Ala Glu Glu Ile Arg Arg Leu Glu Glu Glu Val Phe Arg Leu Ala 
465                 470                 475                 480 


Gly His Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu 
                485                 490                 495     


Phe Asp Glu Leu Arg Leu Pro Ala Leu Gly Lys Thr Gln Lys Thr Gly 
            500                 505                 510         


Lys Arg Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His 
        515                 520                 525             


Pro Ile Val Glu Lys Ile Leu Gln His Arg Glu Leu Thr Lys Leu Lys 
    530                 535                 540                 


Asn Thr Tyr Val Asp Pro Leu Pro Ser Leu Val His Pro Arg Thr Gly 
545                 550                 555                 560 


Arg Leu His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu 
                565                 570                 575     


Ser Ser Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu 
            580                 585                 590         


Gly Gln Arg Ile Arg Arg Ala Phe Val Ala Glu Ala Gly Trp Ala Leu 
        595                 600                 605             


Val Ala Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu 
    610                 615                 620                 


Ser Gly Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Lys Asp Ile 
625                 630                 635                 640 


His Thr Gln Thr Ala Ser Trp Met Phe Gly Val Pro Pro Glu Ala Val 
                645                 650                 655     


Asp Pro Leu Met Arg Arg Ala Ala Lys Thr Val Asn Phe Gly Val Leu 
            660                 665                 670         


Tyr Gly Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr 
        675                 680                 685             


Glu Glu Ala Val Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys 
    690                 695                 700                 


Val Arg Ala Trp Ile Glu Lys Thr Leu Glu Glu Gly Arg Lys Arg Gly 
705                 710                 715                 720 


Tyr Val Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Asn 
                725                 730                 735     


Ala Arg Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn 
            740                 745                 750         


Met Pro Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val 
        755                 760                 765             


Lys Leu Phe Pro Arg Leu Arg Glu Met Gly Ala Arg Met Leu Leu Gln 
    770                 775                 780                 


Val His Asp Glu Leu Leu Leu Glu Ala Pro Gln Ala Arg Ala Glu Glu 
785                 790                 795                 800 


Val Ala Ala Leu Ala Lys Glu Ala Met Glu Lys Ala Tyr Pro Leu Ala 
                805                 810                 815     


Val Pro Leu Glu Val Glu Val Gly Met Gly Glu Asp Trp Leu Ser Ala 
            820                 825                 830         


Lys Gly 
        


<210>  51
<211>  832
<212>  PRT
<213>  Thermus aquaticus

<400>  51

Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      


Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          


Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              


Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  


Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  


Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      


Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         


Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             


Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 


Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 


Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     


Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         


Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             


Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 


Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 


Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     


Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         


Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             


Glu Ser Pro Lys Ala Leu Glu Glu Ala Pro Trp Pro Pro Pro Glu Gly 
    290                 295                 300                 


Ala Phe Val Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp 
305                 310                 315                 320 


Leu Leu Ala Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro 
                325                 330                 335     


Glu Pro Tyr Lys Ala Leu Arg Asp Leu Lys Glu Ala Arg Gly Leu Leu 
            340                 345                 350         


Ala Lys Asp Leu Ser Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro 
        355                 360                 365             


Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn 
    370                 375                 380                 


Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu 
385                 390                 395                 400 


Glu Ala Gly Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asn Leu 
                405                 410                 415     


Trp Gly Arg Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu Tyr Arg Glu 
            420                 425                 430         


Val Glu Arg Pro Leu Ser Ala Val Leu Ala His Met Glu Ala Thr Gly 
        435                 440                 445             


Val Arg Leu Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala 
    450                 455                 460                 


Glu Glu Ile Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His 
465                 470                 475                 480 


Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp 
                485                 490                 495     


Glu Leu Gly Leu Pro Ala Ile Gly Lys Thr Glu Lys Thr Gly Lys Arg 
            500                 505                 510         


Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile 
        515                 520                 525             


Val Glu Lys Ile Leu Gln Tyr Arg Glu Leu Thr Lys Leu Lys Ser Thr 
    530                 535                 540                 


Tyr Ile Asp Pro Leu Pro Asp Leu Ile His Pro Arg Thr Gly Arg Leu 
545                 550                 555                 560 


His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser 
                565                 570                 575     


Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln 
            580                 585                 590         


Arg Ile Arg Arg Ala Phe Ile Ala Glu Glu Gly Trp Leu Leu Val Ala 
        595                 600                 605             


Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly 
    610                 615                 620                 


Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Arg Asp Ile His Thr 
625                 630                 635                 640 


Glu Thr Ala Ser Trp Met Phe Gly Val Pro Arg Glu Ala Val Asp Pro 
                645                 650                 655     


Leu Met Arg Arg Ala Ala Lys Thr Ile Asn Phe Gly Val Leu Tyr Gly 
            660                 665                 670         


Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr Glu Glu 
        675                 680                 685             


Ala Gln Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys Val Arg 
    690                 695                 700                 


Ala Trp Ile Glu Lys Thr Leu Glu Glu Gly Arg Arg Arg Gly Tyr Val 
705                 710                 715                 720 


Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Glu Ala Arg 
                725                 730                 735     


Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn Met Pro 
            740                 745                 750         


Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Lys Leu 
        755                 760                 765             


Phe Pro Arg Leu Glu Glu Met Gly Ala Arg Met Leu Leu Gln Val His 
    770                 775                 780                 


Asp Glu Leu Val Leu Glu Ala Pro Lys Glu Arg Ala Glu Ala Val Ala 
785                 790                 795                 800 


Arg Leu Ala Lys Glu Val Met Glu Gly Val Tyr Pro Leu Ala Val Pro 
                805                 810                 815     


Leu Glu Val Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Glu 
            820                 825                 830         


<210>  52
<211>  877
<212>  PRT
<213>  Bacillus stearothermophilus

<400>  52

Met Arg Leu Lys Lys Lys Leu Val Leu Ile Asp Gly Asn Ser Val Ala 
1               5                   10                  15      


Tyr Arg Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile 
            20                  25                  30          


His Thr Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu 
        35                  40                  45              


Ala Glu Glu Gln Pro Thr His Leu Leu Val Ala Phe Asp Ala Gly Lys 
    50                  55                  60                  


Thr Thr Phe Arg His Glu Thr Phe Gln Glu Tyr Lys Gly Gly Arg Gln 
65                  70                  75                  80  


Gln Thr Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu 
                85                  90                  95      


Leu Lys Thr Tyr Arg Ile Pro Ala Tyr Glu Leu Tyr Ile Tyr Glu Ala 
            100                 105                 110         


Asp Asp Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe 
        115                 120                 125             


Glu Val Lys Ile Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser 
    130                 135                 140                 


Arg His Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu 
145                 150                 155                 160 


Pro Tyr Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu 
                165                 170                 175     


Gln Ile Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile 
            180                 185                 190         


Pro Gly Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Lys 
        195                 200                 205             


Gln Phe Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Val Lys 
    210                 215                 220                 


Gly Glu Lys Val Lys Glu Lys Leu Arg Gln His Arg Asp Leu Ala Leu 
225                 230                 235                 240 


Leu Ser Lys Gln Leu Ala Ser Ile Cys Arg Asp Ala Pro Val Glu Leu 
                245                 250                 255     


Ser Leu Asp Ala Leu Val Tyr Glu Gly Gln Asp Arg Glu Lys Val Ile 
            260                 265                 270         


Ala Leu Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Ala 
        275                 280                 285             


Ala Pro Ala Ala Glu Gly Arg Lys Pro Leu Glu Glu Met Glu Phe Ala 
    290                 295                 300                 


Ile Val Asp Val Ile Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu 
305                 310                 315                 320 


Val Val Glu Val Met Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly 
                325                 330                 335     


Ile Ala Leu Val Asn Glu His Gly Arg Phe Phe Met Arg Pro Glu Thr 
            340                 345                 350         


Ala Leu Ala Asp Ser Gln Phe Leu Ala Trp Leu Ala Asp Glu Thr Lys 
        355                 360                 365             


Lys Lys Ser Met Phe Asp Ala Lys Arg Ala Val Val Ala Leu Lys Trp 
    370                 375                 380                 


Lys Gly Ile Asp Val Arg Gly Val Ala Phe Asp Leu Leu Leu Ala Ala 
385                 390                 395                 400 


Tyr Leu Leu Asn Pro Ala Gln Asp Ala Gly Asp Ile Ala Ala Val Ala 
                405                 410                 415     


Lys Met Lys Gln Tyr Glu Ala Val Arg Ser Asp Glu Ala Val Tyr Gly 
            420                 425                 430         


Lys Gly Val Lys Arg Ser Leu Pro Asp Glu Gln Thr Leu Ala Glu His 
        435                 440                 445             


Leu Val Arg Lys Ala Ala Ala Ile Trp Ala Leu Glu Gln Pro Phe Met 
    450                 455                 460                 


Asp Asp Leu Arg Asn Asn Glu Gln Asp Gln Leu Leu Thr Lys Leu Glu 
465                 470                 475                 480 


Gln Pro Leu Ala Ala Ile Leu Ala Glu Met Glu Phe Thr Gly Val Asn 
                485                 490                 495     


Val Asp Thr Lys Arg Leu Glu Gln Met Gly Ser Glu Leu Ala Glu Gln 
            500                 505                 510         


Leu Arg Ala Ile Glu Gln Arg Ile Tyr Glu His Ala Gly Gln Glu Phe 
        515                 520                 525             


Asn Ile Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu 
    530                 535                 540                 


Gln Leu Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala 
545                 550                 555                 560 


Asp Val Leu Glu Lys Leu Ala Pro His His Glu Ile Val Glu Asn Ile 
                565                 570                 575     


Leu His Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly 
            580                 585                 590         


Leu Leu Lys Val Val Arg Pro Asp Thr Gly Lys Val His Thr Met Phe 
        595                 600                 605             


Asn Gln Thr Leu Thr Gln Thr Gly Arg Leu Ser Ser Ala Glu Pro Asn 
    610                 615                 620                 


Leu Gln Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln 
625                 630                 635                 640 


Ala Phe Val Pro Ser Glu Pro Asp Trp Leu Ile Phe Ala Ala Asp Tyr 
                645                 650                 655     


Ser Gln Ile Glu Leu Arg Val Leu Ala His Ile Ala Asp Asp Asp Asn 
            660                 665                 670         


Leu Ile Glu Ala Phe Gln Arg Asp Leu Asp Ile His Thr Lys Thr Ala 
        675                 680                 685             


Met Asp Ile Phe His Val Ser Glu Glu Glu Val Thr Ala Asn Met Arg 
    690                 695                 700                 


Arg Gln Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Asp 
705                 710                 715                 720 


Tyr Gly Leu Ala Gln Asn Leu Asn Ile Thr Arg Lys Glu Ala Ala Glu 
                725                 730                 735     


Phe Ile Glu Arg Tyr Phe Ala Ser Phe Pro Gly Val Arg Arg Tyr Met 
            740                 745                 750         


Glu Asn Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu 
        755                 760                 765             


Leu His Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Asn 
    770                 775                 780                 


Val Arg Ser Phe Ala Glu Arg Thr Ala Met Asn Thr Pro Ile Gln Gly 
785                 790                 795                 800 


Ser Ala Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Ala Ala Arg 
                805                 810                 815     


Leu Lys Glu Glu Gln Leu Gln Ala Arg Leu Leu Leu Gln Val His Asp 
            820                 825                 830         


Glu Leu Ile Leu Glu Ala Pro Lys Glu Glu Ile Glu Arg Leu Cys Glu 
        835                 840                 845             


Leu Val Pro Glu Val Met Glu Gln Ala Val Ser Ser Val Pro Leu Lys 
    850                 855                 860                 


Val Asp Tyr His Tyr Gly Pro Thr Trp Tyr Asp Ala Lys 
865                 870                 875         


<210>  53
<211>  832
<212>  PRT
<213>  Thermus aquaticus

<400>  53

Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      


Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          


Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              


Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  


Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  


Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      


Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         


Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             


Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 


Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 


Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     


Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         


Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             


Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 


Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 


Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     


Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         


Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             


Glu Ser Pro Lys Ala Leu Glu Glu Ala Pro Trp Pro Pro Pro Glu Gly 
    290                 295                 300                 


Ala Phe Val Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp 
305                 310                 315                 320 


Leu Leu Ala Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro 
                325                 330                 335     


Glu Pro Tyr Lys Ala Leu Arg Asp Leu Lys Glu Ala Arg Gly Leu Leu 
            340                 345                 350         


Ala Lys Asp Leu Ser Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro 
        355                 360                 365             


Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn 
    370                 375                 380                 


Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu 
385                 390                 395                 400 


Glu Ala Gly Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asn Leu 
                405                 410                 415     


Trp Gly Arg Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu Tyr Arg Glu 
            420                 425                 430         


Val Glu Arg Pro Leu Ser Ala Val Leu Ala His Met Glu Ala Thr Gly 
        435                 440                 445             


Val Arg Leu Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala 
    450                 455                 460                 


Glu Glu Ile Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His 
465                 470                 475                 480 


Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp 
                485                 490                 495     


Glu Leu Gly Leu Pro Ala Ile Gly Lys Thr Glu Lys Thr Gly Lys Arg 
            500                 505                 510         


Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile 
        515                 520                 525             


Val Glu Lys Ile Leu Gln Tyr Arg Glu Leu Thr Lys Leu Lys Ser Thr 
    530                 535                 540                 


Tyr Ile Asp Pro Leu Pro Asp Leu Ile His Pro Arg Thr Gly Arg Leu 
545                 550                 555                 560 


His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser 
                565                 570                 575     


Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln 
            580                 585                 590         


Arg Ile Arg Arg Ala Phe Ile Ala Glu Glu Gly Trp Leu Leu Val Ala 
        595                 600                 605             


Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly 
    610                 615                 620                 


Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Arg Asp Ile His Thr 
625                 630                 635                 640 


Glu Thr Ala Ser Trp Met Phe Gly Val Pro Arg Glu Ala Val Asp Pro 
                645                 650                 655     


Leu Met Arg Arg Ala Ala Lys Thr Ile Asn Phe Gly Val Leu Tyr Gly 
            660                 665                 670         


Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr Glu Glu 
        675                 680                 685             


Ala Gln Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys Val Arg 
    690                 695                 700                 


Ala Trp Ile Glu Lys Thr Leu Glu Glu Gly Arg Arg Arg Gly Tyr Val 
705                 710                 715                 720 


Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Glu Ala Arg 
                725                 730                 735     


Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn Met Pro 
            740                 745                 750         


Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Lys Leu 
        755                 760                 765             


Phe Pro Arg Leu Glu Glu Met Gly Ala Arg Met Leu Leu Gln Val His 
    770                 775                 780                 


Asp Glu Leu Val Leu Glu Ala Pro Lys Glu Arg Ala Glu Ala Val Ala 
785                 790                 795                 800 


Arg Leu Ala Lys Glu Val Met Glu Gly Val Tyr Pro Leu Ala Val Pro 
                805                 810                 815     


Leu Glu Val Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Glu 
            820                 825                 830         


<210>  54
<211>  928
<212>  PRT
<213>  Escherichia coli

<400>  54

Met Val Gln Ile Pro Gln Asn Pro Leu Ile Leu Val Asp Gly Ser Ser 
1               5                   10                  15      


Tyr Leu Tyr Arg Ala Tyr His Ala Phe Pro Pro Leu Thr Asn Ser Ala 
            20                  25                  30          


Gly Glu Pro Thr Gly Ala Met Tyr Gly Val Leu Asn Met Leu Arg Ser 
        35                  40                  45              


Leu Ile Met Gln Tyr Lys Pro Thr His Ala Ala Val Val Phe Asp Ala 
    50                  55                  60                  


Lys Gly Lys Thr Phe Arg Asp Glu Leu Phe Glu His Tyr Lys Ser His 
65                  70                  75                  80  


Arg Pro Pro Met Pro Asp Asp Leu Arg Ala Gln Ile Glu Pro Leu His 
                85                  90                  95      


Ala Met Val Lys Ala Met Gly Leu Pro Leu Leu Ala Val Ser Gly Val 
            100                 105                 110         


Glu Ala Asp Asp Val Ile Gly Thr Leu Ala Arg Glu Ala Glu Lys Ala 
        115                 120                 125             


Gly Arg Pro Val Leu Ile Ser Thr Gly Asp Lys Asp Met Ala Gln Leu 
    130                 135                 140                 


Val Thr Pro Asn Ile Thr Leu Ile Asn Thr Met Thr Asn Thr Ile Leu 
145                 150                 155                 160 


Gly Pro Glu Glu Val Val Asn Lys Tyr Gly Val Pro Pro Glu Leu Ile 
                165                 170                 175     


Ile Asp Phe Leu Ala Leu Met Gly Asp Ser Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Pro Gly Val Gly Glu Lys Thr Ala Gln Ala Leu Leu Gln Gly Leu 
        195                 200                 205             


Gly Gly Leu Asp Thr Leu Tyr Ala Glu Pro Glu Lys Ile Ala Gly Leu 
    210                 215                 220                 


Ser Phe Arg Gly Ala Lys Thr Met Ala Ala Lys Leu Glu Gln Asn Lys 
225                 230                 235                 240 


Glu Val Ala Tyr Leu Ser Tyr Gln Leu Ala Thr Ile Lys Thr Asp Val 
                245                 250                 255     


Glu Leu Glu Leu Thr Cys Glu Gln Leu Glu Val Gln Gln Pro Ala Ala 
            260                 265                 270         


Glu Glu Leu Leu Gly Leu Phe Lys Lys Tyr Glu Phe Lys Arg Trp Thr 
        275                 280                 285             


Ala Asp Val Glu Ala Gly Lys Trp Leu Gln Ala Lys Gly Ala Lys Pro 
    290                 295                 300                 


Ala Ala Lys Pro Gln Glu Thr Ser Val Ala Asp Glu Ala Pro Glu Val 
305                 310                 315                 320 


Thr Ala Thr Val Ile Ser Tyr Asp Asn Tyr Val Thr Ile Leu Asp Glu 
                325                 330                 335     


Glu Thr Leu Lys Ala Trp Ile Ala Lys Leu Glu Lys Ala Pro Val Phe 
            340                 345                 350         


Ala Phe Asp Thr Glu Thr Asp Ser Leu Asp Asn Ile Ser Ala Asn Leu 
        355                 360                 365             


Val Gly Leu Ser Phe Ala Ile Glu Pro Gly Val Ala Ala Tyr Ile Pro 
    370                 375                 380                 


Val Ala His Asp Tyr Leu Asp Ala Pro Asp Gln Ile Ser Arg Glu Arg 
385                 390                 395                 400 


Ala Leu Glu Leu Leu Lys Pro Leu Leu Glu Asp Glu Lys Ala Leu Lys 
                405                 410                 415     


Val Gly Gln Asn Leu Lys Tyr Asp Arg Gly Ile Leu Ala Asn Tyr Gly 
            420                 425                 430         


Ile Glu Leu Arg Gly Ile Ala Phe Asp Thr Met Leu Glu Ser Tyr Ile 
        435                 440                 445             


Leu Asn Ser Val Ala Gly Arg His Asp Met Asp Ser Leu Ala Glu Arg 
    450                 455                 460                 


Trp Leu Lys His Lys Thr Ile Thr Phe Glu Glu Ile Ala Gly Lys Gly 
465                 470                 475                 480 


Lys Asn Gln Leu Thr Phe Asn Gln Ile Ala Leu Glu Glu Ala Gly Arg 
                485                 490                 495     


Tyr Ala Ala Glu Asp Ala Asp Val Thr Leu Gln Leu His Leu Lys Met 
            500                 505                 510         


Trp Pro Asp Leu Gln Lys His Lys Gly Pro Leu Asn Val Phe Glu Asn 
        515                 520                 525             


Ile Glu Met Pro Leu Val Pro Val Leu Ser Arg Ile Glu Arg Asn Gly 
    530                 535                 540                 


Val Lys Ile Asp Pro Lys Val Leu His Asn His Ser Glu Glu Leu Thr 
545                 550                 555                 560 


Leu Arg Leu Ala Glu Leu Glu Lys Lys Ala His Glu Ile Ala Gly Glu 
                565                 570                 575     


Glu Phe Asn Leu Ser Ser Thr Lys Gln Leu Gln Thr Ile Leu Phe Glu 
            580                 585                 590         


Lys Gln Gly Ile Lys Pro Leu Lys Lys Thr Pro Gly Gly Ala Pro Ser 
        595                 600                 605             


Thr Ser Glu Glu Val Leu Glu Glu Leu Ala Leu Asp Tyr Pro Leu Pro 
    610                 615                 620                 


Lys Val Ile Leu Glu Tyr Arg Gly Leu Ala Lys Leu Lys Ser Thr Tyr 
625                 630                 635                 640 


Thr Asp Lys Leu Pro Leu Met Ile Asn Pro Lys Thr Gly Arg Val His 
                645                 650                 655     


Thr Ser Tyr His Gln Ala Val Thr Ala Thr Gly Arg Leu Ser Ser Thr 
            660                 665                 670         


Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Asn Glu Glu Gly Arg Arg 
        675                 680                 685             


Ile Arg Gln Ala Phe Ile Ala Pro Glu Asp Tyr Val Ile Val Ser Ala 
    690                 695                 700                 


Asp Tyr Ser Gln Ile Glu Leu Arg Ile Met Ala His Leu Ser Arg Asp 
705                 710                 715                 720 


Lys Gly Leu Leu Thr Ala Phe Ala Glu Gly Lys Asp Ile His Arg Ala 
                725                 730                 735     


Thr Ala Ala Glu Val Phe Gly Leu Pro Leu Glu Thr Val Thr Ser Glu 
            740                 745                 750         


Gln Arg Arg Ser Ala Lys Ala Ile Asn Phe Gly Leu Ile Tyr Gly Met 
        755                 760                 765             


Ser Ala Phe Gly Leu Ala Arg Gln Leu Asn Ile Pro Arg Lys Glu Ala 
    770                 775                 780                 


Gln Lys Tyr Met Asp Leu Tyr Phe Glu Arg Tyr Pro Gly Val Leu Gln 
785                 790                 795                 800 


Tyr Met Glu Arg Thr Arg Ala Gln Ala Lys Glu Gln Gly Tyr Val Glu 
                805                 810                 815     


Thr Leu Asp Gly Arg Arg Leu Tyr Leu Pro Asp Ile Lys Ser Ser Asn 
            820                 825                 830         


Gly Ala Arg Arg Ala Ala Ala Glu Arg Ala Ala Ile Asn Ala Pro Met 
        835                 840                 845             


Gln Gly Thr Ala Ala Asp Ile Ile Lys Arg Ala Met Ile Ala Val Asp 
    850                 855                 860                 


Ala Trp Leu Gln Ala Glu Gln Pro Arg Val Arg Met Ile Met Gln Val 
865                 870                 875                 880 


His Asp Glu Leu Val Phe Glu Val His Lys Asp Asp Val Asp Ala Val 
                885                 890                 895     


Ala Lys Gln Ile His Gln Leu Met Glu Asn Cys Thr Arg Leu Asp Val 
            900                 905                 910         


Pro Leu Leu Val Glu Val Gly Ser Gly Glu Asn Trp Asp Gln Ala His 
        915                 920                 925             


