                         SEQUENCE LISTING

<110>  NovImmune, SA
       Kosco-Vilbois, Marie
       de Graaf, Katrien
       Berney, Thierry
       Giovannoni, Laurianne Santa
       Bosco, Domenico
 
<120>  Anti-TLR4 Antibodies and Methods of Use Thereof

<130>  23135-424001WO

<150>  US 61/431191
<151>  2011-01-10

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Gly Tyr Ser Trp His 
1               5       


<210>  2
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  2

Tyr Ile His Tyr Ser Gly Tyr Thr Asp Phe Asn Pro Ser Leu Lys Thr 
1               5                   10                  15      


<210>  3
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  3

Lys Asp Pro Ser Asp Ala Phe Pro Tyr 
1               5                   


<210>  4
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Ala Ser Gln Ser Ile Ser Asp His Leu His 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  5

Tyr Ala Ser His Ala Ile Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Gln Gly His Ser Phe Pro Leu Thr 
1               5                   


<210>  7
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Asp 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Thr Gly Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile His Tyr Ser Gly Tyr Thr Asp Phe Asn Pro Ser Leu 
    50                  55                  60                  


Lys Thr Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Val Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Asp Pro Ser Asp Ala Phe Pro Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  8
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asp His 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser His Ala Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly His Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  9
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Asp Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Gly Gly Tyr Ser Trp His Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Tyr Ile His Tyr Ser Gly Tyr Thr Asp Phe Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Thr Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Val Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Lys Asp Pro Ser Asp Ala Phe Pro Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Ala Phe Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  10
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val 
            20                  25                  30          


Thr Pro Lys Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile 
        35                  40                  45              


Ser Asp His Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys 
    50                  55                  60                  


Leu Leu Ile Lys Tyr Ala Ser His Ala Ile Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser 
                85                  90                  95      


Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly His Ser 
            100                 105                 110         


Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  11
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Met Ser Ala Ser Arg Leu Ala Gly Thr Leu Ile Pro Ala Met Ala 
1               5                   10                  15      


Phe Leu Ser Cys Val Arg Pro Glu Ser Trp Glu Pro Cys Val Glu Val 
            20                  25                  30          


Val Pro Asn Ile Thr Tyr Gln Cys Met Glu Leu Asn Phe Tyr Lys Ile 
        35                  40                  45              


Pro Asp Asn Leu Pro Phe Ser Thr Lys Asn Leu Asp Leu Ser Phe Asn 
    50                  55                  60                  


Pro Leu Arg His Leu Gly Ser Tyr Ser Phe Phe Ser Phe Pro Glu Leu 
65                  70                  75                  80  


Gln Val Leu Asp Leu Ser Arg Cys Glu Ile Gln Thr Ile Glu Asp Gly 
                85                  90                  95      


Ala Tyr Gln Ser Leu Ser His Leu Ser Thr Leu Ile Leu Thr Gly Asn 
            100                 105                 110         


Pro Ile Gln Ser Leu Ala Leu Gly Ala Phe Ser Gly Leu Ser Ser Leu 
        115                 120                 125             


Gln Lys Leu Val Ala Val Glu Thr Asn Leu Ala Ser Leu Glu Asn Phe 
    130                 135                 140                 


Pro Ile Gly His Leu Lys Thr Leu Lys Glu Leu Asn Val Ala His Asn 
145                 150                 155                 160 


Leu Ile Gln Ser Phe Lys Leu Pro Glu Tyr Phe Ser Asn Leu Thr Asn 
                165                 170                 175     


Leu Glu His Leu Asp Leu Ser Ser Asn Lys Ile Gln Ser Ile Tyr Cys 
            180                 185                 190         


Thr Asp Leu Arg Val Leu His Gln Met Pro Leu Leu Asn Leu Ser Leu 
        195                 200                 205             


Asp Leu Ser Leu Asn Pro Met Asn Phe Ile Gln Pro Gly Ala Phe Lys 
    210                 215                 220                 


Glu Ile Arg Leu His Lys Leu Thr Leu Arg Asn Asn Phe Asp Ser Leu 
225                 230                 235                 240 


Asn Val Met Lys Thr Cys Ile Gln Gly Leu Ala Gly Leu Glu Val His 
                245                 250                 255     


Arg Leu Val Leu Gly Glu Phe Arg Asn Glu Gly Asn Leu Glu Lys Phe 
            260                 265                 270         


Asp Lys Ser Ala Leu Glu Gly Leu Cys Asn Leu Thr Ile Glu Glu Phe 
        275                 280                 285             


Arg Leu Ala Tyr Leu Asp Tyr Tyr Leu Asp Asp Ile Ile Asp Leu Phe 
    290                 295                 300                 


Asn Cys Leu Thr Asn Val Ser Ser Phe Ser Leu Val Ser Val Thr Ile 
305                 310                 315                 320 


Glu Arg Val Lys Asp Phe Ser Tyr Asn Phe Gly Trp Gln His Leu Glu 
                325                 330                 335     


Leu Val Asn Cys Lys Phe Gly Gln Phe Pro Thr Leu Lys Leu Lys Ser 
            340                 345                 350         


Leu Lys Arg Leu Thr Phe Thr Ser Asn Lys Gly Gly Asn Ala Phe Ser 
        355                 360                 365             


Glu Val Asp Leu Pro Ser Leu Glu Phe Leu Asp Leu Ser Arg Asn Gly 
    370                 375                 380                 


Leu Ser Phe Lys Gly Cys Cys Ser Gln Ser Asp Phe Gly Thr Thr Ser 
385                 390                 395                 400 


Leu Lys Tyr Leu Asp Leu Ser Phe Asn Gly Val Ile Thr Met Ser Ser 
                405                 410                 415     


Asn Phe Leu Gly Leu Glu Gln Leu Glu His Leu Asp Phe Gln His Ser 
            420                 425                 430         


Asn Leu Lys Gln Met Ser Glu Phe Ser Val Phe Leu Ser Leu Arg Asn 
        435                 440                 445             


Leu Ile Tyr Leu Asp Ile Ser His Thr His Thr Arg Val Ala Phe Asn 
    450                 455                 460                 


Gly Ile Phe Asn Gly Leu Ser Ser Leu Glu Val Leu Lys Met Ala Gly 
465                 470                 475                 480 


Asn Ser Phe Gln Glu Asn Phe Leu Pro Asp Ile Phe Thr Glu Leu Arg 
                485                 490                 495     


Asn Leu Thr Phe Leu Asp Leu Ser Gln Cys Gln Leu Glu Gln Leu Ser 
            500                 505                 510         


Pro Thr Ala Phe Asn Ser Leu Ser Ser Leu Gln Val Leu Asn Met Ser 
        515                 520                 525             


His Asn Asn Phe Phe Ser Leu Asp Thr Phe Pro Tyr Lys Cys Leu Asn 
    530                 535                 540                 


Ser Leu Gln Val Leu Asp Tyr Ser Leu Asn His Ile Met Thr Ser Lys 
545                 550                 555                 560 


Lys Gln Glu Leu Gln His Phe Pro Ser Ser Leu Ala Phe Leu Asn Leu 
                565                 570                 575     


Thr Gln Asn Asp Phe Ala Cys Thr Cys Glu His Gln Ser Phe Leu Gln 
            580                 585                 590         


Trp Ile Lys Asp Gln Arg Gln Leu Leu Val Glu Val Glu Arg Met Glu 
        595                 600                 605             


Cys Ala Thr Pro Ser Asp Lys Gln Gly Met Pro Val Leu Ser Leu Asn 
    610                 615                 620                 


Ile Thr Cys Gln Met Asn Lys Thr Ile Ile Gly Val Ser Val Leu Ser 
625                 630                 635                 640 


Val Leu Val Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe 
                645                 650                 655     


His Leu Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn 
            660                 665                 670         


Ile Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val 
        675                 680                 685             


Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln 
    690                 695                 700                 


Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala 
705                 710                 715                 720 


Asn Ile Ile His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val 
                725                 730                 735     


Val Ser Gln His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu 
            740                 745                 750         


Ile Ala Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe 
        755                 760                 765             


Ile Val Leu Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu 
    770                 775                 780                 


Leu Tyr Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser 
785                 790                 795                 800 


Val Leu Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu 
                805                 810                 815     


Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn 
            820                 825                 830         


Trp Gln Glu Ala Thr Ser Ile 
        835                 


<210>  12
<211>  1404
<212>  DNA
<213>  Homo sapiens

<400>  12
atgggatgga gctggatctt tctcttcctc ctgtcaggaa ctgcaggtgt acattgccag       60

gtgcagcttc aggagtccgg cccaggactg gtgaagcctt cggacaccct gtccctcacc      120

tgcgctgtct ctggttactc catcaccggt ggttatagct ggcactggat acggcagccc      180

ccagggaagg gactggagtg gatggggtat atccactaca gtggttacac tgacttcaac      240

ccctccctca agactcgaat caccatatca cgtgacacgt ccaagaacca gttctccctg      300

aagctgagct ctgtgaccgc tgtggacact gcagtgtatt actgtgcgag aaaagatccg      360

tccgacgcct ttccttactg gggccaaggg actctggtca ctgtctcttc cgcctccacc      420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      660

aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc caaatcttgt      720

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaaa     1020

tgcaaggtct ccagtaaagc tttccctgcc cccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ctccgggtaa atag                                            1404


<210>  13
<211>  702
<212>  DNA
<213>  Homo sapiens

<400>  13
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa ctacaggtgt ccactccgaa       60

attgtgttga cgcagtctcc agactttcag tctgtgactc caaaggaaaa agtcaccatc      120

acctgcaggg ccagtcagag tatcagcgac cacttacact ggtaccaaca gaaacctgat      180

cagtctccca agctcctcat caaatatgct tcccatgcca tttctggggt cccatcgagg      240

ttcagtggca gtgggtctgg gacagacttc actctcacca tcaatagcct agaggctgaa      300

gatgctgcaa cgtattactg tcagcagggt cacagttttc cgctcacttt cggcggaggg      360

accaaggtgg agatcaaacg tacggtggct gcaccatctg tcttcatctt cccgccatct      420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      660

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                         702


<210>  14
<211>  118
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Asp 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Xaa Gly Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Xaa Gly Tyr Ile His Tyr Ser Gly Tyr Thr Asp Phe Asn Pro Ser Leu 
    50                  55                  60                  


Lys Thr Arg Xaa Thr Xaa Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Val Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Asp Pro Ser Asp Gly Phe Pro Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  15
<211>  118
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Xaa Ser Gly Tyr Ser Ile Thr Gly Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Xaa Ser Tyr Ile His Tyr Ser Gly Tyr Thr Asp Phe Asn Pro Ser Leu 
    50                  55                  60                  


Lys Thr Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Xaa Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Asp Pro Ser Asp Gly Phe Pro Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  16
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp His 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Xaa Tyr Ala Ser His Ala Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Asn Gly His Ser Phe Pro Leu Thr 
1               5                   


<210>  18
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  18

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asp His 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser His Ala Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  19
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Ser 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Xaa 
        35                  40                  45              


Gly Trp Thr Asp Pro Glu Asn Val Asn Ser Ile Tyr Asp Pro Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Xaa Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Xaa Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Asn Gly Val Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  20
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  20

Asp Ser Tyr Ile His 
1               5   


<210>  21
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  21

Trp Thr Asp Pro Glu Asn Val Asn Ser Ile Tyr Asp Pro Arg Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  22
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  22

Gly Tyr Asn Gly Val Tyr Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  23
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa can be any naturally occurring amino acid

<400>  23

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ile Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Arg Thr Tyr Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Xaa Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys His Gln Trp Ser Ser Phe Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  24
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  24

Ser Ala Ser Ser Ser Val Ile Tyr Met His 
1               5                   10  


<210>  25
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  25

Arg Thr Tyr Asn Leu Ala Ser 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  26

His Gln Trp Ser Ser Phe Pro Tyr Thr 
1               5                   


<210>  27
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  Xaa can be any naturally occurring amino acid

<400>  27

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Xaa Thr Tyr 
            20                  25                  30          


Asn Ile Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Ile Tyr Tyr Asn Thr Val 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Xaa Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Xaa Arg Met Ala Glu Gly Arg Tyr Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  28
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  28

Thr Tyr Asn Ile Gly Val Gly 
1               5           


<210>  29
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  29

His Ile Trp Trp Asn Asp Asn Ile Tyr Tyr Asn Thr Val Leu Lys Ser 
1               5                   10                  15      


<210>  30
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Glu Gly Arg Tyr Asp Ala Met Asp Tyr 
1               5                   10      


<210>  31
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  Xaa can be any naturally occurring amino acid

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Xaa Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Asn Ile Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Xaa Ser His Ile Trp Trp Asn Asp Asn Ile Tyr Tyr Asn Thr Val 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Xaa Ser Xaa Asp Asn Ser Lys Asn Thr Xaa 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Xaa Arg Met Ala Glu Gly Arg Tyr Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  32
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa can be any naturally occurring amino acid

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Thr Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Xaa Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Xaa Cys Gln Gln Gly Asn Thr Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  33
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  33

Arg Ala Ser Gln Asp Ile Thr Asn Tyr Leu Asn 
1               5                   10      


<210>  34
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  34

Tyr Thr Ser Lys Leu His Ser 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  35

Gln Gln Gly Asn Thr Phe Pro Trp Thr 
1               5                   


<210>  36
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  36

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Asp 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Thr Gly Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile His Tyr Ser Gly Tyr Thr Asp Phe Asn Pro Ser Leu 
    50                  55                  60                  


Lys Thr Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Val Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Asp Pro Ser Asp Ala Phe Pro Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  37
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  37
caggtgcagc ttcaggagtc cggcccagga ctggtgaagc cttcggacac cctgtccctc       60

acctgcgctg tctctggtta ctccatcacc ggtggttata gctggcactg gatacggcag      120

cccccaggga agggactgga gtggatgggg tatatccact acagtggtta cactgacttc      180

aacccctccc tcaagactcg aatcaccata tcacgtgaca cgtccaagaa ccagttctcc      240

ctgaagctga gctctgtgac cgctgtggac actgcagtgt attactgtgc gagaaaagat      300

ccgtccgacg cctttcctta ctggggccaa gggactctgg tcactgtctc ttcc            354


<210>  38
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  38

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Asp 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Thr Gly Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile His Tyr Ser Gly Tyr Thr Asp Phe Asn Pro Ser Leu 
    50                  55                  60                  


Lys Thr Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Val Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Asp Pro Ser Glu Gly Phe Pro Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  39
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  39
caggtgcagc ttcaggagtc cggcccagga ctggtgaagc cttcggacac cctgtccctc       60

acctgcgctg tctctggtta ctccatcacc ggtggttata gctggcactg gatacggcag      120

cccccaggga agggactgga gtggatgggg tatatccact acagtggtta cactgacttc      180

aacccctccc tcaagactcg aatcaccata tcacgtgaca cgtccaagaa ccagttctcc      240

ctgaagctga gctctgtgac cgctgtggac actgcagtgt attactgtgc gagaaaagat      300

ccgtccgagg gatttcctta ctggggccaa gggactctgg tcactgtctc ttcc            354


<210>  40
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  40

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asp His 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser His Ala Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asn Ser His Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  41
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  41
gaaattgtgt tgacgcagtc tccagacttt cagtctgtga ctccaaagga aaaagtcacc       60

atcacctgca gggccagtca gagtatcagc gaccacttac actggtacca acagaaacct      120

gatcagtctc ccaagctcct catcaaatat gcttcccatg ccatttctgg ggtcccatcg      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcaatag cctagaggct      240

gaagatgctg caacgtatta ctgtcagaat agtcacagtt ttccgctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  42
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  42

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asp His 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser His Ala Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly His Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  43
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  43
gaaattgtgt tgacgcagtc tccagacttt cagtctgtga ctccaaagga aaaagtcacc       60

atcacctgca gggccagtca gagtatcagc gaccacttac actggtacca acagaaacct      120

gatcagtctc ccaagctcct catcaaatat gcttcccatg ccatttctgg ggtcccatcg      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcaatag cctagaggct      240

gaagatgctg caacgtatta ctgtcagcag ggtcacagtt ttccgctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  44
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  44

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asp His 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser His Ala Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asn Ser Ser Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  45
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  45
gaaattgtgt tgacgcagtc tccagacttt cagtctgtga ctccaaagga aaaagtcacc       60

atcacctgca gggccagtca gagtatcagc gaccacttac actggtacca acagaaacct      120

gatcagtctc ccaagctcct catcaaatat gcttcccatg ccatttctgg ggtcccatcg      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcaatag cctagaggct      240

gaagatgctg caacgtatta ctgtcagaat agtagtagtt ttccgctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  46
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  46

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asp His 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser His Ala Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  47
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  47
gaaattgtgt tgacgcagtc tccagacttt cagtctgtga ctccaaagga aaaagtcacc       60

atcacctgca gggccagtca gagtatcagc gaccacttac actggtacca acagaaacct      120

gatcagtctc ccaagctcct catcaaatat gcttcccatg ccatttctgg ggtcccatcg      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcaatag cctagaggct      240

gaagatgctg caacgtatta ctgtcagcag agtcacagtt ttccgctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


