                         SEQUENCE LISTING

<110>  Bracco Imaging SpA
       Bracco Imaging SpA
       ?, ?
 
<120>  HUMAN ANTIBODIES CROSS-REACTING WITH A BACTERIAL AND A SELF 
       ANTIGEN FROM ATHEROSCLEROTIC PLAQUES

<130>  B0656_B

<160>  79    

<170>  PatentIn version 3.3

<210>  1
<211>  445
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(444)
<223>  Fab7816HC

<400>  1
ctc gag tcg ggc cca gga cag gtg aag cct tca cag acc ctg tcc ctc       48
Leu Glu Ser Gly Pro Gly Gln Val Lys Pro Ser Gln Thr Leu Ser Leu         
1               5                   10                  15              

acc tgc act gtc tct ggt ggc tcc atc ggc agt ggt tct tac tcc tgg       96
Thr Cys Thr Val Ser Gly Gly Ser Ile Gly Ser Gly Ser Tyr Ser Trp         
            20                  25                  30                  

aac tgg atc cgg cag ccc gcc ggg agg gga ctg gag tgg att ggg cga      144
Asn Trp Ile Arg Gln Pro Ala Gly Arg Gly Leu Glu Trp Ile Gly Arg         
        35                  40                  45                      

atc tct gac agt ggg aac acc aat ttc aac ccc tcc ctc aag agt cga      192
Ile Ser Asp Ser Gly Asn Thr Asn Phe Asn Pro Ser Leu Lys Ser Arg         
    50                  55                  60                          

gtc acc atg tca gtg gac acg tcc aag aac cag ttc gcc ctg aaa ctg      240
Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ala Leu Lys Leu         
65                  70                  75                  80          

acc tct gtg acc gcc gca gac acg gcc aca tat ttc tgt gcg aga ggg      288
Thr Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly         
                85                  90                  95              

aga ggt att ttg act ggt ctc ttt gac tat tgg ggc cag gga tcc ctg      336
Arg Gly Ile Leu Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Ser Leu         
            100                 105                 110                 

gtc tcc gtc tcc tca gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg      384
Val Ser Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu         
        115                 120                 125                     

gca ccc tcc tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc tgc      432
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys         
    130                 135                 140                         

ctg gtc aag gac t                                                    445
Leu Val Lys Asp                                                         
145                                                                     


<210>  2
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  2

Leu Glu Ser Gly Pro Gly Gln Val Lys Pro Ser Gln Thr Leu Ser Leu 
1               5                   10                  15      


Thr Cys Thr Val Ser Gly Gly Ser Ile Gly Ser Gly Ser Tyr Ser Trp 
            20                  25                  30          


Asn Trp Ile Arg Gln Pro Ala Gly Arg Gly Leu Glu Trp Ile Gly Arg 
        35                  40                  45              


Ile Ser Asp Ser Gly Asn Thr Asn Phe Asn Pro Ser Leu Lys Ser Arg 
    50                  55                  60                  


Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ala Leu Lys Leu 
65                  70                  75                  80  


Thr Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Arg Gly Ile Leu Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Ser Leu 
            100                 105                 110         


Val Ser Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp 
145             


<210>  3
<211>  316
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(315)
<223>  Fab7816LC

<400>  3
tct cca gac tcc ctg gct gtg tct ccg ggc ggg agg gcc acc atc aag       48
Ser Pro Asp Ser Leu Ala Val Ser Pro Gly Gly Arg Ala Thr Ile Lys         
1               5                   10                  15              

tgc gcg tcc agc cag agt gtt ttg gac aac tcc aac cat aag aac tcc       96
Cys Ala Ser Ser Gln Ser Val Leu Asp Asn Ser Asn His Lys Asn Ser         
            20                  25                  30                  

ttg gcg tgg tac cag cag aaa cca gga ctg cct cct aaa ctg ctc att      144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Leu Pro Pro Lys Leu Leu Ile         
        35                  40                  45                      

tac tgg gca tct acc cgg tat tcc ggg gtc cct gac cga ttc agt ggc      192
Tyr Trp Ala Ser Thr Arg Tyr Ser Gly Val Pro Asp Arg Phe Ser Gly         
    50                  55                  60                          

agt ggg tct ggg aca gat ttc act ctc acc atc aac aac ctg cag gct      240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Leu Gln Ala         
65                  70                  75                  80          

gcc gat gtg gca gtt tat ttc tgt cag caa tat tat agt act ccg tgg      288
Ala Asp Val Ala Val Tyr Phe Cys Gln Gln Tyr Tyr Ser Thr Pro Trp         
                85                  90                  95              

acc ttc ggc cag ggg acc aag gtg gag c                                316
Thr Phe Gly Gln Gly Thr Lys Val Glu                                     
            100                 105                                     


<210>  4
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Pro Asp Ser Leu Ala Val Ser Pro Gly Gly Arg Ala Thr Ile Lys 
1               5                   10                  15      


Cys Ala Ser Ser Gln Ser Val Leu Asp Asn Ser Asn His Lys Asn Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Leu Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg Tyr Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Leu Gln Ala 
65                  70                  75                  80  


Ala Asp Val Ala Val Tyr Phe Cys Gln Gln Tyr Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu 
            100                 105 


<210>  5
<211>  455
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(453)
<223>  Fab5LcxHC

<400>  5
ggc cca gga ctg gtg aag cct tcg ggg acc ctg tcc ctc acc tgc gct       48
Gly Pro Gly Leu Val Lys Pro Ser Gly Thr Leu Ser Leu Thr Cys Ala         
1               5                   10                  15              

gtc tct ggt ggc tcc atc agc agt agt aac tgg tgg att tgg gtc cgc       96
Val Ser Gly Gly Ser Ile Ser Ser Ser Asn Trp Trp Ile Trp Val Arg         
            20                  25                  30                  

cag ccc cca ggg aag agg ctg gag tgg att gga gaa atc gat cat agt      144
Gln Pro Pro Gly Lys Arg Leu Glu Trp Ile Gly Glu Ile Asp His Ser         
        35                  40                  45                      

ggg act acc aac tac aac ccg tcc ctc aag agt cga gtc acc atg tca      192
Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Ser         
    50                  55                  60                          

gtg gtc aag tcc aag aac cag ttc tcc ctg aag ctg agc tct gtg acc      240
Val Val Lys Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr         
65                  70                  75                  80          

gcc gcg gac acg gcc gtc tat tac tgt gcg aga gga gca aag gat aac      288
Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala Lys Asp Asn         
                85                  90                  95              

tgg gga ttc gac tac tgg ggc cag gga atc ttg gtc acc gtc tcc tca      336
Trp Gly Phe Asp Tyr Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser         
            100                 105                 110                 

gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag      384
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys         
        115                 120                 125                     

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac      432
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr         
    130                 135                 140                         

ttc ccc gaa ccg gtg acg gtg tc                                       455
Phe Pro Glu Pro Val Thr Val                                             
145                 150                                                 


<210>  6
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Pro Gly Leu Val Lys Pro Ser Gly Thr Leu Ser Leu Thr Cys Ala 
1               5                   10                  15      


Val Ser Gly Gly Ser Ile Ser Ser Ser Asn Trp Trp Ile Trp Val Arg 
            20                  25                  30          


Gln Pro Pro Gly Lys Arg Leu Glu Trp Ile Gly Glu Ile Asp His Ser 
        35                  40                  45              


Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Ser 
    50                  55                  60                  


Val Val Lys Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr 
65                  70                  75                  80  


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala Lys Asp Asn 
                85                  90                  95      


Trp Gly Phe Asp Tyr Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val 
145                 150     


<210>  7
<211>  376
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(375)
<223>  Fab5LcxLC

<400>  7
gcc atg gcc gag ctc acc cag tct cca tcc tcc ctg tct gca tct gta       48
Ala Met Ala Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val         
1               5                   10                  15              

gga gac aga gtc gcc atc act tgc cgg gca agt cag acc atc ctc gac       96
Gly Asp Arg Val Ala Ile Thr Cys Arg Ala Ser Gln Thr Ile Leu Asp         
            20                  25                  30                  

tat tta aat tgg tat cag cag cga ccc ggg aaa gcc cct aag ctc ctc      144
Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu         
        35                  40                  45                      

atc tat tct gca acc cgt tta caa act ggg gtc cca tca agg ttc act      192
Ile Tyr Ser Ala Thr Arg Leu Gln Thr Gly Val Pro Ser Arg Phe Thr         
    50                  55                  60                          

ggc agt aga tct ggg aca gat ttc act ctc acc atc agc agc cta caa      240
Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln         
65                  70                  75                  80          

cct gaa gaa ttt gca act tat tac tgt caa cac gat tac aat gac cct      288
Pro Glu Glu Phe Ala Thr Tyr Tyr Cys Gln His Asp Tyr Asn Asp Pro         
                85                  90                  95              

cga act ttc ggc cag ggg acc aag gtg gaa gtc aaa cga act gtg gct      336
Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys Arg Thr Val Ala         
            100                 105                 110                 

gca cca tct gtc ttc atc ttc ccg cca tct gat gag cag t                376
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln                     
        115                 120                 125                     


<210>  8
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Met Ala Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Ala Ile Thr Cys Arg Ala Ser Gln Thr Ile Leu Asp 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Thr Arg Leu Gln Thr Gly Val Pro Ser Arg Phe Thr 
    50                  55                  60                  


Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Glu Phe Ala Thr Tyr Tyr Cys Gln His Asp Tyr Asn Asp Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125 


<210>  9
<211>  476
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(474)
<223>  Fab1630HC

<400>  9
gga gga ggc ttg gtc aag cct ggc ggg tcc ctg aga ctc tcc tgc aca       48
Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr         
1               5                   10                  15              

gcc tct gga ttc act ttc agt aac ggc tgg atg agc tgg gtc cgc cag       96
Ala Ser Gly Phe Thr Phe Ser Asn Gly Trp Met Ser Trp Val Arg Gln         
            20                  25                  30                  

gct cct ggg aag ggg ctg gag tgg gtc ggc cgg att aga agc aac ccc      144
Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Arg Ile Arg Ser Asn Pro         
        35                  40                  45                      

gac ggt ggc aca aca gac tac gct gca ccc ttc aaa ggc aga ttc acc      192
Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro Phe Lys Gly Arg Phe Thr         
    50                  55                  60                          

atc tca aga gat gat tca aaa aat aca ttg ttt ctg caa gtg acc agc      240
Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Phe Leu Gln Val Thr Ser         
65                  70                  75                  80          

ctg aaa acc gag gac aca ggc gtc tat tac tgc atc aca gat cgg ggt      288
Leu Lys Thr Glu Asp Thr Gly Val Tyr Tyr Cys Ile Thr Asp Arg Gly         
                85                  90                  95              

gac tgg aag tgg ggg gtc cct agg gac ctc acc tac tgg ggc cag gga      336
Asp Trp Lys Trp Gly Val Pro Arg Asp Leu Thr Tyr Trp Gly Gln Gly         
            100                 105                 110                 

acc ctg gtc acc gtc tcc tca gcc tcc acc aag ggc cca tcg gtc ttc      384
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe         
        115                 120                 125                     

ccc ctg gca ccc tcc tcc aag agc acc tct ggg ggc aca gcg gcc ctg      432
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu         
    130                 135                 140                         

ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg gtg acg gtg tc           476
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val                 
145                 150                 155                             


<210>  10
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr 
1               5                   10                  15      


Ala Ser Gly Phe Thr Phe Ser Asn Gly Trp Met Ser Trp Val Arg Gln 
            20                  25                  30          


Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Arg Ile Arg Ser Asn Pro 
        35                  40                  45              


Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro Phe Lys Gly Arg Phe Thr 
    50                  55                  60                  


Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Phe Leu Gln Val Thr Ser 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Thr Gly Val Tyr Tyr Cys Ile Thr Asp Arg Gly 
                85                  90                  95      


Asp Trp Lys Trp Gly Val Pro Arg Asp Leu Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155             


<210>  11
<211>  374
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  Fab1630LC

<400>  11
gcc atg gcc gag ctc acg cag tct cca gac acc ctg tct ttg tct cca       48
Ala Met Ala Glu Leu Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser Pro         
1               5                   10                  15              

ggg gaa aga gcc acc ctc tcc tgt agg gcc agt cag agt gtc gac agc       96
Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Ser         
            20                  25                  30                  

aac tac tta gcc tgg ttc cag cag aag cct ggc cag gct ccc agg ctc      144
Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu         
        35                  40                  45                      

ctc att tat ggt gcg tat agc agg gcc act ggc atc cca gac agg ttc      192
Leu Ile Tyr Gly Ala Tyr Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe         
    50                  55                  60                          

agt ggc agt ggg tct ggg aca gac ttc act ctc acc atc agc aga ctg      240
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu         
65                  70                  75                  80          

gag cct gag gat ttt gtc gtg tat tac tgt cag cag tat ctt agc ccg      288
Glu Pro Glu Asp Phe Val Val Tyr Tyr Cys Gln Gln Tyr Leu Ser Pro         
                85                  90                  95              

ccg atc acc ttc ggc caa ggg aca cga ctg gag act aaa cga act gtg      336
Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Thr Lys Arg Thr Val         
            100                 105                 110                 

gct gca cca tct gtc ttc atc ttc ccg cca tct gat ga                   374
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp                         
        115                 120                                         


<210>  12
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  12

Ala Met Ala Glu Leu Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Ser 
            20                  25                  30          


Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ala Tyr Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Phe Val Val Tyr Tyr Cys Gln Gln Tyr Leu Ser Pro 
                85                  90                  95      


Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Thr Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 


<210>  13
<211>  306
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(306)
<223>  Fab248HC

<400>  13
ctc gag tct ggg gga ggc ttg gtc aag cct gga ggg tcc ctg agg ctc       48
Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu         
1               5                   10                  15              

tcc tgt gca gcc tct gga ttc acc ttc agt gac tac tac atg agt tgg       96
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp         
            20                  25                  30                  

atc cgc cag gct cca ggg aag ggg ctg gaa ttt ata tca tac att agt      144
Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Ile Ser Tyr Ile Ser         
        35                  40                  45                      

agt ggt ggt gac acc ata cac cac gca gac tct gtg aag ggc cga ttc      192
Ser Gly Gly Asp Thr Ile His His Ala Asp Ser Val Lys Gly Arg Phe         
    50                  55                  60                          

acc atc tcc agg gac aac gcc aag aag tca ctg tat ctc caa atg aac      240
Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr Leu Gln Met Asn         
65                  70                  75                  80          

agc ctg aga gtc gag gac acg gcc gta tat tac tgt gcg tgc cgt ggg      288
Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys Ala Cys Arg Gly         
                85                  90                  95              

gtc tgg ggc cag gga acc                                              306
Val Trp Gly Gln Gly Thr                                                 
            100                                                         


<210>  14
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  14

Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu 
1               5                   10                  15      


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp 
            20                  25                  30          


Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Ile Ser Tyr Ile Ser 
        35                  40                  45              


Ser Gly Gly Asp Thr Ile His His Ala Asp Ser Val Lys Gly Arg Phe 
    50                  55                  60                  


Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr Leu Gln Met Asn 
65                  70                  75                  80  


Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys Ala Cys Arg Gly 
                85                  90                  95      


Val Trp Gly Gln Gly Thr 
            100         


<210>  15
<211>  291
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(291)
<223>  Fab248LC

<400>  15
tct cca gcc acc gtg tct gtg tct cca ggg gaa aga gcc acc ctc tcc       48
Ser Pro Ala Thr Val Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser         
1               5                   10                  15              

tgc agg gcc agt cag agt att agt ttc cac tta gcc tgg tac cag cag       96
Cys Arg Ala Ser Gln Ser Ile Ser Phe His Leu Ala Trp Tyr Gln Gln         
            20                  25                  30                  

aaa cct ggc cag gct ccc agt ctc ctc atc tac gga aca tcc acc agg      144
Lys Pro Gly Gln Ala Pro Ser Leu Leu Ile Tyr Gly Thr Ser Thr Arg         
        35                  40                  45                      

gcc act ggt atc cca gcc agg ttc agt ggc agt ggg tct ggg aca gag      192
Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu         
    50                  55                  60                          

ttc act ctc acc atc agc agc ctg cag tct gaa gat tct gcg gtt tat      240
Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Ser Ala Val Tyr         
65                  70                  75                  80          

tac tgt cag cag tat cat aac tgg cct ccc ctc act ttc ggc gga ggg      288
Tyr Cys Gln Gln Tyr His Asn Trp Pro Pro Leu Thr Phe Gly Gly Gly         
                85                  90                  95              

acc                                                                  291
Thr                                                                     
                                                                        


<210>  16
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  16

Ser Pro Ala Thr Val Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser 
1               5                   10                  15      


Cys Arg Ala Ser Gln Ser Ile Ser Phe His Leu Ala Trp Tyr Gln Gln 
            20                  25                  30          


Lys Pro Gly Gln Ala Pro Ser Leu Leu Ile Tyr Gly Thr Ser Thr Arg 
        35                  40                  45              


Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 
    50                  55                  60                  


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Ser Ala Val Tyr 
65                  70                  75                  80  


Tyr Cys Gln Gln Tyr His Asn Trp Pro Pro Leu Thr Phe Gly Gly Gly 
                85                  90                  95      


Thr 
    


<210>  17
<211>  440
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(438)
<223>  PL12HC22

<400>  17
ggg gct gag gtg aag aag act ggg tcc tca gtg aag gtg tcc tgc atg       48
Gly Ala Glu Val Lys Lys Thr Gly Ser Ser Val Lys Val Ser Cys Met         
1               5                   10                  15              

gtc tcc gga aac agc ttc acc cag cgt ttc ctg cac tgg gtg cga cag       96
Val Ser Gly Asn Ser Phe Thr Gln Arg Phe Leu His Trp Val Arg Gln         
            20                  25                  30                  

gcc ccc gga caa gcg ctt gag tgg atg ggg tgg atc aca cct ttc agt      144
Ala Pro Gly Gln Ala Leu Glu Trp Met Gly Trp Ile Thr Pro Phe Ser         
        35                  40                  45                      

gga aat acc tac tac gca cag aaa ttc cag gac aga ctc acc att acg      192
Gly Asn Thr Tyr Tyr Ala Gln Lys Phe Gln Asp Arg Leu Thr Ile Thr         
    50                  55                  60                          

ggg gac agg tct gtg agt aca gcc tac atg gag ttg agc agc ctg aga      240
Gly Asp Arg Ser Val Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg         
65                  70                  75                  80          

tct gac gac aca gcc atc tat tac tgt gtg att ttt ggt ctt gac tac      288
Ser Asp Asp Thr Ala Ile Tyr Tyr Cys Val Ile Phe Gly Leu Asp Tyr         
                85                  90                  95              

tgg ggc aag gga acc ctg gtc acc gtc tcc tca gcc tcc acc aag ggc      336
Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly         
            100                 105                 110                 

cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg ggc      384
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly         
        115                 120                 125                     

aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg gtg      432
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val         
    130                 135                 140                         

acg gtg tc                                                           440
Thr Val                                                                 
145                                                                     


<210>  18
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  18

Gly Ala Glu Val Lys Lys Thr Gly Ser Ser Val Lys Val Ser Cys Met 
1               5                   10                  15      


Val Ser Gly Asn Ser Phe Thr Gln Arg Phe Leu His Trp Val Arg Gln 
            20                  25                  30          


Ala Pro Gly Gln Ala Leu Glu Trp Met Gly Trp Ile Thr Pro Phe Ser 
        35                  40                  45              


Gly Asn Thr Tyr Tyr Ala Gln Lys Phe Gln Asp Arg Leu Thr Ile Thr 
    50                  55                  60                  


Gly Asp Arg Ser Val Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg 
65                  70                  75                  80  


Ser Asp Asp Thr Ala Ile Tyr Tyr Cys Val Ile Phe Gly Leu Asp Tyr 
                85                  90                  95      


Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
            100                 105                 110         


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
        115                 120                 125             


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
    130                 135                 140                 


Thr Val 
145     


<210>  19
<211>  455
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(453)
<223>  new1

<400>  19
ggg gga ggc ttg ctc aag cca gga ggg tcc ctg aga ctc tcc tgt gta       48
Gly Gly Gly Leu Leu Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Val         
1               5                   10                  15              

gcc tct gga ttc agc ata agc gac ttc tac atg agt tgg atc cgc cag       96
Ala Ser Gly Phe Ser Ile Ser Asp Phe Tyr Met Ser Trp Ile Arg Gln         
            20                  25                  30                  

gct cca ggg aaa gga ctg gag tgg atc tca tac ctc agt ggt ggc agt      144
Ala Pro Gly Lys Gly Leu Glu Trp Ile Ser Tyr Leu Ser Gly Gly Ser         
        35                  40                  45                      

act tac agg agc cac gca gac tct ggg aag ggc cga ttc acc atc tcc      192
Thr Tyr Arg Ser His Ala Asp Ser Gly Lys Gly Arg Phe Thr Ile Ser         
    50                  55                  60                          

aga gac aac gcc aag aat tca ctg ttt ttg caa atg agt agc ctg gga      240
Arg Asp Asn Ala Lys Asn Ser Leu Phe Leu Gln Met Ser Ser Leu Gly         
65                  70                  75                  80          

gtc gag gac acg gcc gtg tat ttt tgt gcg agg cat gtg gga gtg gcg      288
Val Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg His Val Gly Val Ala         
                85                  90                  95              

act gcc ttt gat atc tgg ggc caa ggg aca gtg gtc act gtc tcc tca      336
Thr Ala Phe Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser         
            100                 105                 110                 

gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag      384
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys         
        115                 120                 125                     

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac      432
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr         
    130                 135                 140                         

ttc ccc gaa ccg gtg acg gtg tc                                       455
Phe Pro Glu Pro Val Thr Val                                             
145                 150                                                 


<210>  20
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Gly Gly Leu Leu Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Val 
1               5                   10                  15      


Ala Ser Gly Phe Ser Ile Ser Asp Phe Tyr Met Ser Trp Ile Arg Gln 
            20                  25                  30          


Ala Pro Gly Lys Gly Leu Glu Trp Ile Ser Tyr Leu Ser Gly Gly Ser 
        35                  40                  45              


Thr Tyr Arg Ser His Ala Asp Ser Gly Lys Gly Arg Phe Thr Ile Ser 
    50                  55                  60                  


Arg Asp Asn Ala Lys Asn Ser Leu Phe Leu Gln Met Ser Ser Leu Gly 
65                  70                  75                  80  


Val Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg His Val Gly Val Ala 
                85                  90                  95      


Thr Ala Phe Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val 
145                 150     


<210>  21
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)
<223>  new2

<400>  21
ggg gga ggc ttg gtc gag cct gga ggg tcc ctg aga ctc tcc tgt gaa       48
Gly Gly Gly Leu Val Glu Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu         
1               5                   10                  15              

gcc act gga ttc acc ttc agt gac tac tac atg agt tgg gtc cgc cag       96
Ala Thr Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Val Arg Gln         
            20                  25                  30                  

gct cct ggg aag ggg ctg gaa tgg att gca tac att agt act ggt agt      144
Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Tyr Ile Ser Thr Gly Ser         
        35                  40                  45                      

agt tac ata aat tat gca gac tct aag aag ggc cga ttc acc atc tcc      192
Ser Tyr Ile Asn Tyr Ala Asp Ser Lys Lys Gly Arg Phe Thr Ile Ser         
    50                  55                  60                          

aga aac aac gcc aag aac tca ctg tat ctg caa ctg aac agc ctg aga      240
Arg Asn Asn Ala Lys Asn Ser Leu Tyr Leu Gln Leu Asn Ser Leu Arg         
65                  70                  75                  80          

gtc gac gac acg gcc gtg tat tac tgt gcg aga tcg aca cag agt ttc      288
Val Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Gln Ser Phe         
                85                  90                  95              

ggg ttg tta tta ccc ctc gtc ctc ttt gac cac tgg ggc cag gga acc      336
Gly Leu Leu Leu Pro Leu Val Leu Phe Asp His Trp Gly Gln Gly Thr         
            100                 105                 110                 


<210>  22
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  22

Gly Gly Gly Leu Val Glu Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu 
1               5                   10                  15      


Ala Thr Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Val Arg Gln 
            20                  25                  30          


Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Tyr Ile Ser Thr Gly Ser 
        35                  40                  45              


Ser Tyr Ile Asn Tyr Ala Asp Ser Lys Lys Gly Arg Phe Thr Ile Ser 
    50                  55                  60                  


Arg Asn Asn Ala Lys Asn Ser Leu Tyr Leu Gln Leu Asn Ser Leu Arg 
65                  70                  75                  80  


Val Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Gln Ser Phe 
                85                  90                  95      


Gly Leu Leu Leu Pro Leu Val Leu Phe Asp His Trp Gly Gln Gly Thr 
            100                 105                 110         


<210>  23
<211>  369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(369)
<223>  new3

<400>  23
ggg gga ggc ttg gta cag cct ggg ggg tcc ctg aga ctc tcc tgt gca       48
Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala         
1               5                   10                  15              

gcc tct gga tcc acc tta atc aac tat gcc atg agc tgg gtc cgc cag       96
Ala Ser Gly Ser Thr Leu Ile Asn Tyr Ala Met Ser Trp Val Arg Gln         
            20                  25                  30                  

gct cca ggg aag ggg ctg gag tgg gtc tca gtt att agt gga act ggt      144
Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Thr Gly         
        35                  40                  45                      

gtt ggc aca tac tac gca gac tcc gtg agg ggc cgg ttc acc atc tcc      192
Val Gly Thr Tyr Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser         
    50                  55                  60                          

aga gac gat tcc aac aac acg gtg gat ctg caa atg aat agc ctg aga      240
Arg Asp Asp Ser Asn Asn Thr Val Asp Leu Gln Met Asn Ser Leu Arg         
65                  70                  75                  80          

gcc gag gac acg gcc gta tat tac tgt gcg aaa gat ttc caa gtc ttc      288
Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Asp Phe Gln Val Phe         
                85                  90                  95              

ggt gac tac att tct cta ggc tat tgg ggc cag gga atc ctg gtc acc      336
Gly Asp Tyr Ile Ser Leu Gly Tyr Trp Gly Gln Gly Ile Leu Val Thr         
            100                 105                 110                 

gtc gcc tca gcc tcc acc aag ggc cca tcg gtc                          369
Val Ala Ser Ala Ser Thr Lys Gly Pro Ser Val                             
        115                 120                                         


<210>  24
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  24

Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
1               5                   10                  15      


Ala Ser Gly Ser Thr Leu Ile Asn Tyr Ala Met Ser Trp Val Arg Gln 
            20                  25                  30          


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Thr Gly 
        35                  40                  45              


Val Gly Thr Tyr Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser 
    50                  55                  60                  


Arg Asp Asp Ser Asn Asn Thr Val Asp Leu Gln Met Asn Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Asp Phe Gln Val Phe 
                85                  90                  95      


Gly Asp Tyr Ile Ser Leu Gly Tyr Trp Gly Gln Gly Ile Leu Val Thr 
            100                 105                 110         


Val Ala Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120             


<210>  25
<211>  458
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(456)
<223>  PL12HC11A

<400>  25
ggg gga ggc ttg gca cag cct ggg ggg tcc ctg aga ctc tcc tgt gca       48
Gly Gly Gly Leu Ala Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala         
1               5                   10                  15              

gcc tct gga ttc acc ttt agc agc cat ggc atg agc tgg gtc cgc cag       96
Ala Ser Gly Phe Thr Phe Ser Ser His Gly Met Ser Trp Val Arg Gln         
            20                  25                  30                  

gct cca ggg aag ggg ctg gag tgg gtc tca gct att agt ggg agt ggt      144
Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly         
        35                  40                  45                      

ggt aac act tac tac gca gac tcc gtg aag ggc cgg ttc acc atc tcc      192
Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser         
    50                  55                  60                          

aga gac att tcc aag aac acg ctg tat ctg caa atg aac agc ctg aga      240
Arg Asp Ile Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg         
65                  70                  75                  80          

gcc gaa gac acg gcc cta tat tac tgt gcg aga ggg ggc gcc tat ggt      288
Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Gly Gly Ala Tyr Gly         
                85                  90                  95              

tcg ggg agt tat aag tac tgg ggc cag gga acc ctg gtc acc gtc tcc      336
Ser Gly Ser Tyr Lys Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser         
            100                 105                 110                 

tca gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc      384
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser         
        115                 120                 125                     

aag agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac      432
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp         
    130                 135                 140                         

tac ttc ccc gaa ccg gtg acg gtg tc                                   458
Tyr Phe Pro Glu Pro Val Thr Val                                         
145                 150                                                 


<210>  26
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  26

Gly Gly Gly Leu Ala Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
1               5                   10                  15      


Ala Ser Gly Phe Thr Phe Ser Ser His Gly Met Ser Trp Val Arg Gln 
            20                  25                  30          


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly 
        35                  40                  45              


Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    50                  55                  60                  


Arg Asp Ile Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Gly Gly Ala Tyr Gly 
                85                  90                  95      


Ser Gly Ser Tyr Lys Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val 
145                 150         


<210>  27
<211>  473
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(471)
<223>  PL12HC28

<400>  27
ggg gga ggc gtg gtc cag cct ggg agg tcc ctg aga ctc tcc tgt gca       48
Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala         
1               5                   10                  15              

gcc tct gga ttc acc ttc agt agc tat gac atg cac tgg gtc cgc cag       96
Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp Met His Trp Val Arg Gln         
            20                  25                  30                  

gct cca ggc aag ggg ctg gag tgg gtg gca att ata ttg gat gat gga      144
Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ile Ile Leu Asp Asp Gly         
        35                  40                  45                      

agt aat aaa tac tat gca gcc tcc gtg aag ggc cga ttc acc atc tcc      192
Ser Asn Lys Tyr Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser         
    50                  55                  60                          

aga gac aat tcc aag aac acg ctg tat ctg caa atg aac agc ctg aga      240
Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg         
65                  70                  75                  80          

gct gag gac acg gct gtg tat tac tgt gcg aaa gtg cga ata ggg aag      288
Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Arg Ile Gly Lys         
                85                  90                  95              

gtc aat aag gtc aat aag tcc tac ttt gac tcc tgg ggc cag gga acc      336
Val Asn Lys Val Asn Lys Ser Tyr Phe Asp Ser Trp Gly Gln Gly Thr         
            100                 105                 110                 

ctg gtc acc gtc tcc tca gcc tcc acc aag ggc cca tcg gtc ttc ccc      384
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro         
        115                 120                 125                     

ctg gca ccc tcc tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc      432
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly         
    130                 135                 140                         

tgc ctg gtc aag gac tac ttc ccc gaa ccg gtg acg gtg tc               473
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val                     
145                 150                 155                             


<210>  28
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  28

Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala 
1               5                   10                  15      


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp Met His Trp Val Arg Gln 
            20                  25                  30          


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ile Ile Leu Asp Asp Gly 
        35                  40                  45              


Ser Asn Lys Tyr Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser 
    50                  55                  60                  


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Arg Ile Gly Lys 
                85                  90                  95      


Val Asn Lys Val Asn Lys Ser Tyr Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155         


<210>  29
<211>  377
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(375)
<223>  PL12LC18

<400>  29
gcc atg gcc gag ctc acg cag tct cca ggc acc ctg tct ttg tct cca       48
Ala Met Ala Glu Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro         
1               5                   10                  15              

ggg gaa aga gtc acc ctc tcc tgc agg gcc agc cag agc gtt agt agc       96
Gly Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser         
            20                  25                  30                  

aac tac tta acc tgg tac cag cag aaa cct ggc cag gct ccc agg ctc      144
Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu         
        35                  40                  45                      

ctc atc tat ggt gca tcc aga agg gcc act ggc atc cca gac agg ttc      192
Leu Ile Tyr Gly Ala Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe         
    50                  55                  60                          

agt ggc agt ggg tct ggg acc gac ttc act ctc acc ata agc aga ctg      240
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu         
65                  70                  75                  80          

gag cct gaa gat ttt gca gtt tat tac tgt caa cat tat ggt agc tca      288
Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Ser Ser         
                85                  90                  95              

cct cca ttc cct ttc ggc cct ggg acc aaa gtg gat gtc aaa cga act      336
Pro Pro Phe Pro Phe Gly Pro Gly Thr Lys Val Asp Val Lys Arg Thr         
            100                 105                 110                 

gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat ga               377
Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp                     
        115                 120                 125                     


<210>  30
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  30

Ala Met Ala Glu Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
            20                  25                  30          


Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ala Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Ser Ser 
                85                  90                  95      


Pro Pro Phe Pro Phe Gly Pro Gly Thr Lys Val Asp Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125 


<210>  31
<211>  374
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  PL12LC5

<400>  31
gcc atg gcc gag ctc acg cag tct cca ggc acc ctg tct ttg tct cca       48
Ala Met Ala Glu Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro         
1               5                   10                  15              

ggg gaa aga gcc acc ctc tcc tgc agg gcc agt cag agc att cgc agc       96
Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Arg Ser         
            20                  25                  30                  

aac ttc tta gcc tgg tac cag cag aaa cct ggc cag gct ccc agg ctc      144
Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu         
        35                  40                  45                      

ctc atc ttt ggt gca tcg aac agg gcc act ggc atc cca gac agg ttc      192
Leu Ile Phe Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe         
    50                  55                  60                          

agt ggc agt ggg tct ggg aca gac ttc act ctc acc atc agt aga ctg      240
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu         
65                  70                  75                  80          

gag cct gaa gat ttt gcg gtt tat tac tgt cag cag tat agt agc tca      288
Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Ser         
                85                  90                  95              

ccg gac act ttt ggc cag ggg acc aag ctg gag atc aaa cga act gtg      336
Pro Asp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val         
            100                 105                 110                 

gct gca cca tct gtc ttc atc ttc ccg cca tct gat ga                   374
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp                         
        115                 120                                         


<210>  32
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  32

Ala Met Ala Glu Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Arg Ser 
            20                  25                  30          


Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Phe Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Ser 
                85                  90                  95      


Pro Asp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 


<210>  33
<211>  371
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(369)
<223>  PL12LC26

<400>  33
gcc atg gcc gag ctc acc cag tct cca tcc tcc ctg tct gca tct gta       48
Ala Met Ala Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val         
1               5                   10                  15              

gga gac aga gtc acc gtc act tgc cgg gca agt cag acc att gcc aac       96
Gly Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln Thr Ile Ala Asn         
            20                  25                  30                  

tat tta aat tgg tat cag caa aaa cca ggg aaa gcc cct aac ctc ctg      144
Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu         
        35                  40                  45                      

atc caa gct gct tcc act ttg caa ggt ggg gtc cca tca agg ttc agt      192
Ile Gln Ala Ala Ser Thr Leu Gln Gly Gly Val Pro Ser Arg Phe Ser         
    50                  55                  60                          

ggc agt cga tct ggg aca gat ttc act ctc acc atc acc agt ctg cag      240
Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln         
65                  70                  75                  80          

cct gag gat ttt gca act tac ttc tgt caa cag agt ttc agc gcc ccc      288
Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Phe Ser Ala Pro         
                85                  90                  95              

tgg acg ttc ggc caa ggg acc aaa gtg gaa atc aaa cga act gtg gct      336
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala         
            100                 105                 110                 

gca cca tct gtc ttc atc ttc ccg cca tct gat ga                       371
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp                             
        115                 120                                         


<210>  34
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  34

Ala Met Ala Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln Thr Ile Ala Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu 
        35                  40                  45              


Ile Gln Ala Ala Ser Thr Leu Gln Gly Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Phe Ser Ala Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120             


<210>  35
<211>  30
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(30)
<223>  Fab7816-HC2-CDR1

<400>  35
ggt ggc tcc atc ggc agt ggt tct tac tcc                               30
Gly Gly Ser Ile Gly Ser Gly Ser Tyr Ser                                 
1               5                   10                                  


<210>  36
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  36

Gly Gly Ser Ile Gly Ser Gly Ser Tyr Ser 
1               5                   10  


<210>  37
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(21)
<223>  Fab7816-HC2-CDR2

<400>  37
atc tct gac agt ggg aac acc                                           21
Ile Ser Asp Ser Gly Asn Thr                                             
1               5                                                       


<210>  38
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  38

Ile Ser Asp Ser Gly Asn Thr 
1               5           


<210>  39
<211>  45
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(45)
<223>  Fab7816-HC2-CDR3

<400>  39
tgt gcg aga ggg aga ggt att ttg act ggt ctc ttt gac tat tgg           45
Cys Ala Arg Gly Arg Gly Ile Leu Thr Gly Leu Phe Asp Tyr Trp             
1               5                   10                  15              


<210>  40
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  40

Cys Ala Arg Gly Arg Gly Ile Leu Thr Gly Leu Phe Asp Tyr Trp 
1               5                   10                  15  


<210>  41
<211>  36
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(36)
<223>  Fab7816-LC4-CDR1

<400>  41
cag agt gtt ttg gac aac tcc aac cat aag aac tcc                       36
Gln Ser Val Leu Asp Asn Ser Asn His Lys Asn Ser                         
1               5                   10                                  


<210>  42
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  42

Gln Ser Val Leu Asp Asn Ser Asn His Lys Asn Ser 
1               5                   10          


<210>  43
<211>  33
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(33)
<223>  Fab7816-LC4-CDR3

<400>  43
acc ttc tgt cag caa tat tat agt act ccg tgg                           33
Thr Phe Cys Gln Gln Tyr Tyr Ser Thr Pro Trp                             
1               5                   10                                  


<210>  44
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  44

Thr Phe Cys Gln Gln Tyr Tyr Ser Thr Pro Trp 
1               5                   10      


<210>  45
<211>  27
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(27)
<223>  Fab5Lcx-HC2-CDR1

<400>  45
ggt ggc tcc atc agc agt agt aac tgg                                   27
Gly Gly Ser Ile Ser Ser Ser Asn Trp                                     
1               5                                                       


<210>  46
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  46

Gly Gly Ser Ile Ser Ser Ser Asn Trp 
1               5                   


<210>  47
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(21)
<223>  Fab5Lcx-HC2-CDR2

<400>  47
atc gat cat agt ggg act acc                                           21
Ile Asp His Ser Gly Thr Thr                                             
1               5                                                       


<210>  48
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  48

Ile Asp His Ser Gly Thr Thr 
1               5           


<210>  49
<211>  42
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(42)
<223>  Fab5Lcx-HC2-CDR3

<400>  49
tgt gcg aga gga gca aag gat aac tgg gga ttc gac tac tgg               42
Cys Ala Arg Gly Ala Lys Asp Asn Trp Gly Phe Asp Tyr Trp                 
1               5                   10                                  


<210>  50
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  50

Cys Ala Arg Gly Ala Lys Asp Asn Trp Gly Phe Asp Tyr Trp 
1               5                   10                  


<210>  51
<211>  33
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(33)
<223>  Fab5Lcx-LC8-CDR3

<400>  51
tgt caa cac gat tac aat gac cct cga act ttc                           33
Cys Gln His Asp Tyr Asn Asp Pro Arg Thr Phe                             
1               5                   10                                  


<210>  52
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  52

Cys Gln His Asp Tyr Asn Asp Pro Arg Thr Phe 
1               5                   10      


<210>  53
<211>  24
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(24)
<223>  Fab1630-HC10-CDR1

<400>  53
gga ttc act ttc agt aac ggc tgg                                       24
Gly Phe Thr Phe Ser Asn Gly Trp                                         
1               5                                                       


<210>  54
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  54

Gly Phe Thr Phe Ser Asn Gly Trp 
1               5               


<210>  55
<211>  30
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(30)
<223>  Fab1630-HC10-CDR2

<400>  55
att aga agc aac ccc gac ggt ggc aca aca                               30
Ile Arg Ser Asn Pro Asp Gly Gly Thr Thr                                 
1               5                   10                                  


<210>  56
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  56

Ile Arg Ser Asn Pro Asp Gly Gly Thr Thr 
1               5                   10  


<210>  57
<211>  57
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(57)
<223>  Fab1630-HC10-CDR3

<400>  57
tgc atc aca gat cgg ggt gac tgg aag tgg ggg gtc cct agg gac ctc       48
Cys Ile Thr Asp Arg Gly Asp Trp Lys Trp Gly Val Pro Arg Asp Leu         
1               5                   10                  15              

acc tac tgg                                                           57
Thr Tyr Trp                                                             
                                                                        


<210>  58
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  58

Cys Ile Thr Asp Arg Gly Asp Trp Lys Trp Gly Val Pro Arg Asp Leu 
1               5                   10                  15      


Thr Tyr Trp 
            


<210>  59
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(21)
<223>  Fab1630-LC12-CDR1

<400>  59
aac tac cag agt gtc gac agc                                           21
Asn Tyr Gln Ser Val Asp Ser                                             
1               5                                                       


<210>  60
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  60

Asn Tyr Gln Ser Val Asp Ser 
1               5           


<210>  61
<211>  33
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(33)
<223>  Fab1630-LC12-CDR3

<400>  61
tgt cag cag tat ctt agc ccg ccg atc acc ttc                           33
Cys Gln Gln Tyr Leu Ser Pro Pro Ile Thr Phe                             
1               5                   10                                  


<210>  62
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  62

Cys Gln Gln Tyr Leu Ser Pro Pro Ile Thr Phe 
1               5                   10      


<210>  63
<211>  24
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(24)
<223>  Fab248-HC14-CDR1

<400>  63
gga ttc acc ttc agt gac tac tac                                       24
Gly Phe Thr Phe Ser Asp Tyr Tyr                                         
1               5                                                       


<210>  64
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  64

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  65
<211>  24
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(24)
<223>  Fab248-HC14-CDR2

<400>  65
att agt agt ggt ggt gac acc ata                                       24
Ile Ser Ser Gly Gly Asp Thr Ile                                         
1               5                                                       


<210>  66
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  66

Ile Ser Ser Gly Gly Asp Thr Ile 
1               5               


<210>  67
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(21)
<223>  Fab248-HC14-CDR3

<400>  67
tgt gcg tgc cgt ggg gtc tgg                                           21
Cys Ala Cys Arg Gly Val Trp                                             
1               5                                                       


<210>  68
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  68

Cys Ala Cys Arg Gly Val Trp 
1               5           


<210>  69
<211>  18
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(18)
<223>  Fab248-LC16-CDR1

<400>  69
cag agt att agt ttc cac                                               18
Gln Ser Ile Ser Phe His                                                 
1               5                                                       


<210>  70
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  70

Gln Ser Ile Ser Phe His 
1               5       


<210>  71
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer


<220>
<221>  primer_bind
<222>  (1)..(47)
<223>  primer OmpK36NcolFW

<400>  71
gcgctagtat gccatgggca tgaaagttaa agtactgtcc ctcctgg                   47


<210>  72
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer


<220>
<221>  protein_bind
<222>  (1)..(45)
<223>  primer OmpK36XholRW

<400>  72
gcgcttcctc gatacctcga gctagaactg gtaaaccagg cccag                     45


<210>  73
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer


<220>
<221>  primer_bind
<222>  (1)..(46)
<223>  primer OmpK36BamHIFW

<400>  73
gcgctagtct gggatccgat gaaagttaaa gtactgtccc tcctgg                    46


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer


<220>
<221>  primer_bind
<222>  (1)..(20)
<223>  primer T7FWpET

<400>  74
taatacgact cactataggg                                                 20


<210>  75
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer


<220>
<221>  primer_bind
<222>  (1)..(19)
<223>  primer T7termpET

<400>  75
ggtggctcca tcggcagtgg ttcttactcc                                      30


<210>  76
<211>  1098
<212>  DNA
<213>  Klebsiella pneumoniae


<220>
<221>  CDS
<222>  (1)..(1098)
<223>  OmpK36

<400>  76
atg aaa gtt aaa gta ctg tcc ctc ctg gta ccg gct ctg ctg gta gca       48
Met Lys Val Lys Val Leu Ser Leu Leu Val Pro Ala Leu Leu Val Ala         
1               5                   10                  15              

ggc gca gca aat gcg gct gaa att tat aac aaa gac ggc aac aaa tta       96
Gly Ala Ala Asn Ala Ala Glu Ile Tyr Asn Lys Asp Gly Asn Lys Leu         
            20                  25                  30                  

gac ctg tac ggt aaa att gac ggt ctg cac tac ttc tct gac gac aag      144
Asp Leu Tyr Gly Lys Ile Asp Gly Leu His Tyr Phe Ser Asp Asp Lys         
        35                  40                  45                      

agc gtc gac ggc gac cag acc tac atg cgt gta ggc gtg aaa ggc gaa      192
Ser Val Asp Gly Asp Gln Thr Tyr Met Arg Val Gly Val Lys Gly Glu         
    50                  55                  60                          

acc cag atc aac gac cag ctg acc ggt tac ggc cag tgg gaa tac aac      240
Thr Gln Ile Asn Asp Gln Leu Thr Gly Tyr Gly Gln Trp Glu Tyr Asn         
65                  70                  75                  80          

gtt cag gcg aac aac act gaa agc tcc agc gat cag gca tgg act cgt      288
Val Gln Ala Asn Asn Thr Glu Ser Ser Ser Asp Gln Ala Trp Thr Arg         
                85                  90                  95              

ctg gca ttc gca ggc ctg aaa ttt ggc gac gcg ggc tct ttc gac tac      336
Leu Ala Phe Ala Gly Leu Lys Phe Gly Asp Ala Gly Ser Phe Asp Tyr         
            100                 105                 110                 

ggt cgt aac tac ggc gta gta tac gtc gta acg tcc tgg acc gac gtt      384
Gly Arg Asn Tyr Gly Val Val Tyr Val Val Thr Ser Trp Thr Asp Val         
        115                 120                 125                     

ctg ccg gaa ttc ggc ggc gac acc tac ggt tct gac aac ttc ctg cag      432
Leu Pro Glu Phe Gly Gly Asp Thr Tyr Gly Ser Asp Asn Phe Leu Gln         
    130                 135                 140                         

tcc cgt gct aac ggc gtt gca acc tac cgt aac tct gat ttc ttc ggt      480
Ser Arg Ala Asn Gly Val Ala Thr Tyr Arg Asn Ser Asp Phe Phe Gly         
145                 150                 155                 160         

ctg gtt gac ggc ctg aac ttt gct ctg cag tat cag ggt aaa aac ggc      528
Leu Val Asp Gly Leu Asn Phe Ala Leu Gln Tyr Gln Gly Lys Asn Gly         
                165                 170                 175             

agc gtc agc ggc gaa ggc gcg acc aac aac ggt cgt ggt tgg agc aaa      576
Ser Val Ser Gly Glu Gly Ala Thr Asn Asn Gly Arg Gly Trp Ser Lys         
            180                 185                 190                 

cag aac ggc gac ggc ttc ggc acc tct ctg acc tac gat att tgg gat      624
Gln Asn Gly Asp Gly Phe Gly Thr Ser Leu Thr Tyr Asp Ile Trp Asp         
        195                 200                 205                     

ggc atc agc gct ggt ttc gcg tac tct cac tcc aaa cgt acc gac gag      672
Gly Ile Ser Ala Gly Phe Ala Tyr Ser His Ser Lys Arg Thr Asp Glu         
    210                 215                 220                         

cag aat agt gtt ccg gca ctg ggt cgt ggc gac aac gct gaa acc tac      720
Gln Asn Ser Val Pro Ala Leu Gly Arg Gly Asp Asn Ala Glu Thr Tyr         
225                 230                 235                 240         

acc ggt ggt ctg aaa tac gac gcc aac aac atc tac ctg gcc tct cag      768
Thr Gly Gly Leu Lys Tyr Asp Ala Asn Asn Ile Tyr Leu Ala Ser Gln         
                245                 250                 255             

tac acc cag acc tac aac gca act cgc gcc ggt tcc ctg ggc ttt gca      816
Tyr Thr Gln Thr Tyr Asn Ala Thr Arg Ala Gly Ser Leu Gly Phe Ala         
            260                 265                 270                 

aac aaa gcg cag aac ttc gaa gtg gtt gct cag tac cag ttc gac ttc      864
Asn Lys Ala Gln Asn Phe Glu Val Val Ala Gln Tyr Gln Phe Asp Phe         
        275                 280                 285                     

ggt ctg cgt ccg tct gtg gct tac ctg cag tct aaa ggt aag gat ctg      912
Gly Leu Arg Pro Ser Val Ala Tyr Leu Gln Ser Lys Gly Lys Asp Leu         
    290                 295                 300                         

gag cgc ggc tac ggc gac cag gac atc ctg aaa tat gtt gac gtt ggc      960
Glu Arg Gly Tyr Gly Asp Gln Asp Ile Leu Lys Tyr Val Asp Val Gly         
305                 310                 315                 320         

gcg acc tac tac ttc aac aaa aac atg tcc acc tat gtt gac tac aaa     1008
Ala Thr Tyr Tyr Phe Asn Lys Asn Met Ser Thr Tyr Val Asp Tyr Lys         
                325                 330                 335             

atc aac ctg ctg gac gac aac agc ttc acc cgc aac gcc ggt atc tct     1056
Ile Asn Leu Leu Asp Asp Asn Ser Phe Thr Arg Asn Ala Gly Ile Ser         
            340                 345                 350                 

acc gac gac gtg gtt gca ctg ggc ctg gtt tac cag ttc taa             1098
Thr Asp Asp Val Val Ala Leu Gly Leu Val Tyr Gln Phe                     
        355                 360                 365                     


<210>  77
<211>  365
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  77

Met Lys Val Lys Val Leu Ser Leu Leu Val Pro Ala Leu Leu Val Ala 
1               5                   10                  15      


Gly Ala Ala Asn Ala Ala Glu Ile Tyr Asn Lys Asp Gly Asn Lys Leu 
            20                  25                  30          


Asp Leu Tyr Gly Lys Ile Asp Gly Leu His Tyr Phe Ser Asp Asp Lys 
        35                  40                  45              


Ser Val Asp Gly Asp Gln Thr Tyr Met Arg Val Gly Val Lys Gly Glu 
    50                  55                  60                  


Thr Gln Ile Asn Asp Gln Leu Thr Gly Tyr Gly Gln Trp Glu Tyr Asn 
65                  70                  75                  80  


Val Gln Ala Asn Asn Thr Glu Ser Ser Ser Asp Gln Ala Trp Thr Arg 
                85                  90                  95      


Leu Ala Phe Ala Gly Leu Lys Phe Gly Asp Ala Gly Ser Phe Asp Tyr 
            100                 105                 110         


Gly Arg Asn Tyr Gly Val Val Tyr Val Val Thr Ser Trp Thr Asp Val 
        115                 120                 125             


Leu Pro Glu Phe Gly Gly Asp Thr Tyr Gly Ser Asp Asn Phe Leu Gln 
    130                 135                 140                 


Ser Arg Ala Asn Gly Val Ala Thr Tyr Arg Asn Ser Asp Phe Phe Gly 
145                 150                 155                 160 


Leu Val Asp Gly Leu Asn Phe Ala Leu Gln Tyr Gln Gly Lys Asn Gly 
                165                 170                 175     


Ser Val Ser Gly Glu Gly Ala Thr Asn Asn Gly Arg Gly Trp Ser Lys 
            180                 185                 190         


Gln Asn Gly Asp Gly Phe Gly Thr Ser Leu Thr Tyr Asp Ile Trp Asp 
        195                 200                 205             


Gly Ile Ser Ala Gly Phe Ala Tyr Ser His Ser Lys Arg Thr Asp Glu 
    210                 215                 220                 


Gln Asn Ser Val Pro Ala Leu Gly Arg Gly Asp Asn Ala Glu Thr Tyr 
225                 230                 235                 240 


Thr Gly Gly Leu Lys Tyr Asp Ala Asn Asn Ile Tyr Leu Ala Ser Gln 
                245                 250                 255     


Tyr Thr Gln Thr Tyr Asn Ala Thr Arg Ala Gly Ser Leu Gly Phe Ala 
            260                 265                 270         


Asn Lys Ala Gln Asn Phe Glu Val Val Ala Gln Tyr Gln Phe Asp Phe 
        275                 280                 285             


Gly Leu Arg Pro Ser Val Ala Tyr Leu Gln Ser Lys Gly Lys Asp Leu 
    290                 295                 300                 


Glu Arg Gly Tyr Gly Asp Gln Asp Ile Leu Lys Tyr Val Asp Val Gly 
305                 310                 315                 320 


Ala Thr Tyr Tyr Phe Asn Lys Asn Met Ser Thr Tyr Val Asp Tyr Lys 
                325                 330                 335     


Ile Asn Leu Leu Asp Asp Asn Ser Phe Thr Arg Asn Ala Gly Ile Ser 
            340                 345                 350         


Thr Asp Asp Val Val Ala Leu Gly Leu Val Tyr Gln Phe 
        355                 360                 365 


<210>  78
<211>  36
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(36)
<223>  Fab248LC-CDR3

<400>  78
tgt cag cag tat cat aac tgg cct ccc ctc act ttc                       36
Cys Gln Gln Tyr His Asn Trp Pro Pro Leu Thr Phe                         
1               5                   10                                  


<210>  79
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  79

Cys Gln Gln Tyr His Asn Trp Pro Pro Leu Thr Phe 
1               5                   10          


