                         SEQUENCE LISTING

<110>  UNIVERSITY HEALTH NETWORK
 
<120>  PROGNOSTIC SIGNATURE FOR ORAL SQUAMOUS CELL CARCINOMA

<130>  10723-393

<150>  US 61/431,512
<151>  2011-01-11

<160>  85    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Homo Sapien

<400>  1
tgctcatgct tttcaaccag                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Homo Sapien

<400>  2
ccgcaacacg atgtaagttg                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Homo Sapien

<400>  3
agcagaagga ctgccggggt                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Homo Sapien

<400>  4
caatgcctgg ctggcccaca                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Homo Sapien

<400>  5
ggtcggcctg cactgtcacc                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Homo Sapien

<400>  6
ggggaagctg ctgcactggg                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Homo Sapien

<400>  7
aggagctgcc aaagccctga                                                   20


<210>  8
<211>  22
<212>  DNA
<213>  Homo Sapien

<400>  8
acctgctcca tccacaacac cg                                                22


<210>  9
<211>  20
<212>  DNA
<213>  Homo Sapien

<400>  9
ggcctccaag gagtaagacc                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Homo Sapien

<400>  10
aggggtctac atggcaactg                                                   20


<210>  11
<211>  2081
<212>  DNA
<213>  Homo Sapien

<400>  11
agcatgagtc agacagcctc tggctttctg gaagggcaag gactctatat atacagaggg       60

agcttcctag ctgggatatt ggagcagcaa gaggctggga agccatcact taccttgcac      120

tgagaaagaa gacaaaggcc agtatgcaca gctttcctcc actgctgctg ctgctgttct      180

ggggtgtggt gtctcacagc ttcccagcga ctctagaaac acaagagcaa gatgtggact      240

tagtccagaa atacctggaa aaatactaca acctgaagaa tgatgggagg caagttgaaa      300

agcggagaaa tagtggccca gtggttgaaa aattgaagca aatgcaggaa ttctttgggc      360

tgaaagtgac tgggaaacca gatgctgaaa ccctgaaggt gatgaagcag cccagatgtg      420

gagtgcctga tgtggctcag tttgtcctca ctgaggggaa ccctcgctgg gagcaaacac      480

atctgaccta caggattgaa aattacacgc cagatttgcc aagagcagat gtggaccatg      540

ccattgagaa agccttccaa ctctggagta atgtcacacc tctgacattc accaaggtct      600

ctgagggtca agcagacatc atgatatctt ttgtcagggg agatcatcgg gacaactctc      660

cttttgatgg acctggagga aatcttgctc atgcttttca accaggccca ggtattggag      720

gggatgctca ttttgatgaa gatgaaaggt ggaccaacaa tttcagagag tacaacttac      780

atcgtgttgc agctcatgaa ctcggccatt ctcttggact ctcccattct actgatatcg      840

gggctttgat gtaccctagc tacaccttca gtggtgatgt tcagctagct caggatgaca      900

ttgatggcat ccaagccata tatggacgtt cccaaaatcc tgtccagccc atcggcccac      960

aaaccccaaa agcgtgtgac agtaagctaa cctttgatgc tataactacg attcggggag     1020

aagtgatgtt ctttaaagac agattctaca tgcgcacaaa tcccttctac ccggaagttg     1080

agctcaattt catttctgtt ttctggccac aactgccaaa tgggcttgaa gctgcttacg     1140

aatttgccga cagagatgaa gtccggtttt tcaaagggaa taagtactgg gctgttcagg     1200

gacagaatgt gctacacgga taccccaagg acatctacag ctcctttggc ttccctagaa     1260

ctgtgaagca tatcgatgct gctctttctg aggaaaacac tggaaaaacc tacttctttg     1320

ttgctaacaa atactggagg tatgatgaat ataaacgatc tatggatcca ggttatccca     1380

aaatgatagc acatgacttt cctggaattg gccacaaagt tgatgcagtt ttcatgaaag     1440

atggattttt ctatttcttt catggaacaa gacaatacaa atttgatcct aaaacgaaga     1500

gaattttgac tctccagaaa gctaatagct ggttcaactg caggaaaaat tgaacattac     1560

taatttgaat ggaaaacaca tggtgtgagt ccaaagaagg tgttttcctg aagaactgtc     1620

tattttctca gtcattttta acctctagag tcactgatac acagaatata atcttattta     1680

tacctcagtt tgcatatttt tttactattt agaatgtagc cctttttgta ctgatataat     1740

ttagttccac aaatggtggg tacaaaaagt caagtttgtg gcttatggat tcatataggc     1800

cagagttgca aagatctttt ccagagtatg caactctgac gttgatccca gagagcagct     1860

tcagtgacaa acatatcctt tcaagacaga aagagacagg agacatgagt ctttgccgga     1920

ggaaaagcag ctcaagaaca catgtgcagt cactggtgtc accctggata ggcaagggat     1980

aactcttcta acacaaaata agtgttttat gtttggaata aagtcaacct tgtttctact     2040

gttttataca ctttcaaaaa aaaaaaaaaa aaaaaaaaaa a                         2081


<210>  12
<211>  403
<212>  PRT
<213>  Homo Sapien

<400>  12

Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu 
1               5                   10                  15      


Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala 
            20                  25                  30          


Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu 
        35                  40                  45              


Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val 
    50                  55                  60                  


Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro 
65                  70                  75                  80  


Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser 
                85                  90                  95      


Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly 
            100                 105                 110         


Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp 
        115                 120                 125             


Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr 
    130                 135                 140                 


Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu 
145                 150                 155                 160 


Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe 
                165                 170                 175     


Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala 
            180                 185                 190         


Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr 
        195                 200                 205             


Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile 
    210                 215                 220                 


Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn 
225                 230                 235                 240 


Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro 
                245                 250                 255     


Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp 
            260                 265                 270         


Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln 
        275                 280                 285             


Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe 
    290                 295                 300                 


Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr 
305                 310                 315                 320 


Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu 
                325                 330                 335     


Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp 
            340                 345                 350         


Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly 
        355                 360                 365             


Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys 
    370                 375                 380                 


Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys 
385                 390                 395                 400 


Arg Lys Asn 
            


<210>  13
<211>  6549
<212>  DNA
<213>  Homo Sapien

<400>  13
gcttggagcc gccgcacccg ggacggtgcg tagcgctgga agtccggcct tccgagagct       60

agctgtccgc cgcggccccc gcacgccggg cagccgtccc tcgccgcctc gggcgcgcca      120

ccatggggcc ccggctcagc gtctggctgc tgctgctgcc cgccgccctt ctgctccacg      180

aggagcacag ccgggccgct gcgaagggtg gctgtgctgg ctctggctgt ggcaaatgtg      240

actgccatgg agtgaaggga caaaagggtg aaagaggcct cccggggtta caaggtgtca      300

ttgggtttcc tggaatgcaa ggacctgagg ggccacaggg accaccagga caaaagggtg      360

atactggaga accaggacta cctggaacaa aagggacaag aggacctccg ggagcatctg      420

gctaccctgg aaacccagga cttcccggaa ttcctggcca agacggcccg ccaggccccc      480

caggtattcc aggatgcaat ggcacaaagg gggagagagg gccgctcggg cctcctggct      540

tgcctggttt cgctggaaat cccggaccac caggcttacc agggatgaag ggtgatccag      600

gtgagatact tggccatgtg cccgggatgc tgttgaaagg tgaaagagga tttcccggaa      660

tcccagggac tccaggccca ccaggactgc cagggcttca aggtcctgtt gggcctccag      720

gatttaccgg accaccaggt cccccaggcc ctcccggccc tccaggtgaa aagggacaaa      780

tgggcttaag ttttcaagga ccaaaaggtg acaagggtga ccaaggggtc agtgggcctc      840

caggagtacc aggacaagct caagttcaag aaaaaggaga cttcgccacc aagggagaaa      900

agggccaaaa aggtgaacct ggatttcagg ggatgccagg ggtcggagag aaaggtgaac      960

ccggaaaacc aggacccaga ggcaaacccg gaaaagatgg tgacaaaggg gaaaaaggga     1020

gtcccggttt tcctggtgaa cccgggtacc caggactcat aggccgccag ggcccgcagg     1080

gagaaaaggg tgaagcaggt cctcctggcc cacctggaat tgttataggc acaggacctt     1140

tgggagaaaa aggagagagg ggctaccctg gaactccggg gccaagagga gagccaggcc     1200

caaaaggttt cccaggacta ccaggccaac ccggacctcc aggcctccct gtacctgggc     1260

aggctggtgc ccctggcttc cctggtgaaa gaggagaaaa aggtgaccga ggatttcctg     1320

gtacatctct gccaggacca agtggaagag atgggctccc gggtcctcct ggttcccctg     1380

ggccccctgg gcagcctggc tacacaaatg gaattgtgga atgtcagccc ggacctccag     1440

gtgaccaggg tcctcctgga attccagggc agccaggatt tataggcgaa attggagaga     1500

aaggtcaaaa aggagagagt tgcctcatct gtgatataga cggatatcgg gggcctcccg     1560

ggccacaggg acccccggga gaaataggtt tcccagggca gccaggggcc aagggcgaca     1620

gaggtttgcc tggcagagat ggtgttgcag gagtgccagg ccctcaaggt acaccagggc     1680

tgataggcca gccaggagcc aagggggagc ctggtgagtt ttatttcgac ttgcggctca     1740

aaggtgacaa aggagaccca ggctttccag gacagcccgg catgacaggg agagcgggtt     1800

ctcctggaag agatggccat ccgggtcttc ctggccccaa gggctcgccg ggttctgtag     1860

gattgaaagg agagcgtggc ccccctggag gagttggatt cccaggcagt cgtggtgaca     1920

ccggcccccc tgggcctcca ggatatggtc ctgctggtcc cattggtgac aaaggacaag     1980

caggctttcc tggaggccct ggatccccag gcctgccagg tccaaagggt gaaccaggaa     2040

aaattgttcc tttaccaggc ccccctggag cagaaggact gccggggtcc ccaggcttcc     2100

caggtcccca aggagaccga ggctttcccg gaaccccagg aaggccaggc ctgccaggag     2160

agaagggcgc tgtgggccag ccaggcattg gatttccagg gccccccggc cccaaaggtg     2220

ttgacggctt acctggagac atggggccac cggggactcc aggtcgcccg ggatttaatg     2280

gcttacctgg gaacccaggt gtgcagggcc agaagggaga gcctggagtt ggtctaccgg     2340

gactcaaagg tttgccaggt cttcccggca ttcctggcac acccggggag aaggggagca     2400

ttggggtacc aggcgttcct ggagaacatg gagcgatcgg accccctggg cttcagggga     2460

tcagaggtga accgggacct cctggattgc caggctccgt ggggtctcca ggagttccag     2520

gaataggccc ccctggagct aggggtcccc ctggaggaca gggaccaccg gggttgtcag     2580

gccctcctgg aataaaagga gagaagggtt tccccggatt ccctggactg gacatgccgg     2640

gccctaaagg agataaaggg gctcaaggac tccctggcat aacgggacag tcggggctcc     2700

ctggccttcc tggacagcag ggggctcctg ggattcctgg gtttccaggt tccaagggag     2760

aaatgggcgt catggggacc cccgggcagc cgggctcacc aggaccagtg ggtgctcctg     2820

gattaccggg tgaaaaaggg gaccatggct ttccgggctc ctcaggaccc aggggagacc     2880

ctggcttgaa aggtgataag ggggatgtcg gtctccctgg caagcctggc tccatggata     2940

aggtggacat gggcagcatg aagggccaga aaggagacca aggagagaaa ggacaaattg     3000

gaccaattgg tgagaaggga tcccgaggag accctgggac cccaggagtg cctggaaagg     3060

acgggcaggc aggacagcct gggcagccag gacctaaagg tgatccaggt ataagtggaa     3120

ccccaggtgc tccaggactt ccgggaccaa aaggatctgt tggtggaatg ggcttgccag     3180

gaacacctgg agagaaaggt gtgcctggca tccctggccc acaaggttca cctggcttac     3240

ctggagacaa aggtgcaaaa ggagagaaag ggcaggcagg cccacctggc ataggcatcc     3300

cagggctgcg aggtgaaaag ggagatcaag ggatagcggg tttcccagga agccctggag     3360

agaagggaga aaaaggaagc attgggatcc caggaatgcc agggtcccca ggccttaaag     3420

ggtctcccgg gagtgttggc tatccaggaa gtcctgggct acctggagaa aaaggtgaca     3480

aaggcctccc aggattggat ggcatccctg gtgtcaaagg agaagcaggt cttcctggga     3540

ctcctggccc cacaggccca gctggccaga aaggggagcc aggcagtgat ggaatcccgg     3600

ggtcagcagg agagaagggt gaaccaggtc taccaggaag aggattccca gggtttccag     3660

gggccaaagg agacaaaggt tcaaagggtg aggtgggttt cccaggatta gccgggagcc     3720

caggaattcc tggatccaaa ggagagcaag gattcatggg tcctccgggg ccccagggac     3780

agccggggtt accgggatcc ccaggccatg ccacggaggg gcccaaagga gaccgcggac     3840

ctcagggcca gcctggcctg ccaggacttc cgggacccat ggggcctcca gggcttcctg     3900

ggattgatgg agttaaaggt gacaaaggaa atccaggctg gccaggagca cccggtgtcc     3960

cagggcccaa gggagaccct ggattccagg gcatgcctgg tattggtggc tctccaggaa     4020

tcacaggctc taagggtgat atggggcctc caggagttcc aggatttcaa ggtccaaaag     4080

gtcttcctgg cctccaggga attaaaggtg atcaaggcga tcaaggcgtc ccgggagcta     4140

aaggtctccc gggtcctcct ggccccccag gtccttacga catcatcaaa ggggagcccg     4200

ggctccctgg tcctgagggc cccccagggc tgaaagggct tcagggactg ccaggcccga     4260

aaggccagca aggtgttaca ggattggtgg gtatacctgg acctccaggt attcctgggt     4320

ttgacggtgc ccctggccag aaaggagaga tgggacctgc cgggcctact ggtccaagag     4380

gatttccagg tccaccaggc cccgatgggt tgccaggatc catggggccc ccaggcaccc     4440

catctgttga tcacggcttc cttgtgacca ggcatagtca aacaatagat gacccacagt     4500

gtccttctgg gaccaaaatt ctttaccacg ggtactcttt gctctacgtg caaggcaatg     4560

aacgggccca tggccaggac ttgggcacgg ccggcagctg cctgcgcaag ttcagcacaa     4620

tgcccttcct gttctgcaat attaacaacg tgtgcaactt tgcatcacga aatgactact     4680

cgtactggct gtccacccct gagcccatgc ccatgtcaat ggcacccatc acgggggaaa     4740

acataagacc atttattagt aggtgtgctg tgtgtgaggc gcctgccatg gtgatggccg     4800

tgcacagcca gaccattcag atcccaccgt gccccagcgg gtggtcctcg ctgtggatcg     4860

gctactcttt tgtgatgcac accagcgctg gtgcagaagg ctctggccaa gccctggcgt     4920

cccccggctc ctgcctggag gagtttagaa gtgcgccatt catcgagtgt cacggccgtg     4980

ggacctgcaa ttactacgca aacgcttaca gcttttggct cgccaccata gagaggagcg     5040

agatgttcaa gaagcctacg ccgtccacct tgaaggcagg ggagctgcgc acgcacgtca     5100

gccgctgcca agtctgtatg agaagaacat aatgaagcct gactcagcta atgtcacaac     5160

atggtgctac ttcttcttct ttttgttaac agcaacgaac cctagaaata tatcctgtgt     5220

acctcactgt ccaatatgaa aaccgtaaag tgccttatag gaatttgcgt aactaacaca     5280

ccctgcttca ttgacctcta cttgctgaag gagaaaaaga cagcgataag ctttcaatag     5340

tggcatacca aatggcactt ttgatgaaat aaaatatcaa tattttctgc aatccaatgc     5400

actgatgtgt gaagtgagaa ctccatcaga aaaccaaagg gtgctaggag gtgtgggtgc     5460

cttccatact gtttgcccat tttcattctt gtattataat taattttcta cccccagaga     5520

taaatgtttg tttatatcac tgtctagctg tttcaaaatt taggtccctt ggtctgtaca     5580

aataatagca atgtaaaaat ggttttttga acctccaaat ggaattacag actcagtagc     5640

catatcttcc aaccccccag tataaatttc tgtctttctg ctatgtgtgg tactttgcag     5700

ctgcttttgc agaaatcaca attttcctgt ggaataaaga tggtccaaaa atagtcaaaa     5760

attaaatata tatatatatt agtaatttat atagatgtca gcaattaggc agatcaaggt     5820

ttagtttaac ttccactgtt aaaataaagc ttacatagtt ttcttccttt gaaagactgt     5880

gctgtccttt aacataggtt tttaaagact aggatattga atgtgaaaca tccgttttca     5940

ttgttcactt ctaaaccaaa aattatgtgt tgccaaaacc aaacccaggt tcatgaatat     6000

ggtgtctatt atagtgaaac atgtactttg agcttattgt ttttattctg tattaaatat     6060

tttcagggtt ttaaacacta atcacaaact gaatgacttg acttcaaaag caacaacctt     6120

aaaggccgtc atttcattag tattcctcat tctgcatcct ggcttgaaaa acagctctgt     6180

tgaatcacag tatcagtatt ttcacacgta agcacattcg ggccatttcc gtggtttctc     6240

atgagctgtg ttcacagacc tcagcagggc atcgcatgga ccgcaggagg gcagattcgg     6300

accactaggc ctgaaatgac atttcactaa aagtctccaa aacatttcta agactactaa     6360

ggccttttat gtaatttctt taaatgtgta tttcttaaga attcaaattt gtaataaaac     6420

tatttgtata aaaattaagc ttttattaat ttgttgctag tattgccaca gacgcattaa     6480

aagaaactta ctgcacaagc tgctaataaa tttgtaagct ttgcatacct taaaaaaaaa     6540

aaaaaaaaa                                                             6549


<210>  14
<211>  1669
<212>  PRT
<213>  Homo Sapien

<400>  14

Met Gly Pro Arg Leu Ser Val Trp Leu Leu Leu Leu Pro Ala Ala Leu 
1               5                   10                  15      


Leu Leu His Glu Glu His Ser Arg Ala Ala Ala Lys Gly Gly Cys Ala 
            20                  25                  30          


Gly Ser Gly Cys Gly Lys Cys Asp Cys His Gly Val Lys Gly Gln Lys 
        35                  40                  45              


Gly Glu Arg Gly Leu Pro Gly Leu Gln Gly Val Ile Gly Phe Pro Gly 
    50                  55                  60                  


Met Gln Gly Pro Glu Gly Pro Gln Gly Pro Pro Gly Gln Lys Gly Asp 
65                  70                  75                  80  


Thr Gly Glu Pro Gly Leu Pro Gly Thr Lys Gly Thr Arg Gly Pro Pro 
                85                  90                  95      


Gly Ala Ser Gly Tyr Pro Gly Asn Pro Gly Leu Pro Gly Ile Pro Gly 
            100                 105                 110         


Gln Asp Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Cys Asn Gly Thr 
        115                 120                 125             


Lys Gly Glu Arg Gly Pro Leu Gly Pro Pro Gly Leu Pro Gly Phe Ala 
    130                 135                 140                 


Gly Asn Pro Gly Pro Pro Gly Leu Pro Gly Met Lys Gly Asp Pro Gly 
145                 150                 155                 160 


Glu Ile Leu Gly His Val Pro Gly Met Leu Leu Lys Gly Glu Arg Gly 
                165                 170                 175     


Phe Pro Gly Ile Pro Gly Thr Pro Gly Pro Pro Gly Leu Pro Gly Leu 
            180                 185                 190         


Gln Gly Pro Val Gly Pro Pro Gly Phe Thr Gly Pro Pro Gly Pro Pro 
        195                 200                 205             


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Gln Met Gly Leu Ser Phe 
    210                 215                 220                 


Gln Gly Pro Lys Gly Asp Lys Gly Asp Gln Gly Val Ser Gly Pro Pro 
225                 230                 235                 240 


Gly Val Pro Gly Gln Ala Gln Val Gln Glu Lys Gly Asp Phe Ala Thr 
                245                 250                 255     


Lys Gly Glu Lys Gly Gln Lys Gly Glu Pro Gly Phe Gln Gly Met Pro 
            260                 265                 270         


Gly Val Gly Glu Lys Gly Glu Pro Gly Lys Pro Gly Pro Arg Gly Lys 
        275                 280                 285             


Pro Gly Lys Asp Gly Asp Lys Gly Glu Lys Gly Ser Pro Gly Phe Pro 
    290                 295                 300                 


Gly Glu Pro Gly Tyr Pro Gly Leu Ile Gly Arg Gln Gly Pro Gln Gly 
305                 310                 315                 320 


Glu Lys Gly Glu Ala Gly Pro Pro Gly Pro Pro Gly Ile Val Ile Gly 
                325                 330                 335     


Thr Gly Pro Leu Gly Glu Lys Gly Glu Arg Gly Tyr Pro Gly Thr Pro 
            340                 345                 350         


Gly Pro Arg Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Leu Pro Gly 
        355                 360                 365             


Gln Pro Gly Pro Pro Gly Leu Pro Val Pro Gly Gln Ala Gly Ala Pro 
    370                 375                 380                 


Gly Phe Pro Gly Glu Arg Gly Glu Lys Gly Asp Arg Gly Phe Pro Gly 
385                 390                 395                 400 


Thr Ser Leu Pro Gly Pro Ser Gly Arg Asp Gly Leu Pro Gly Pro Pro 
                405                 410                 415     


Gly Ser Pro Gly Pro Pro Gly Gln Pro Gly Tyr Thr Asn Gly Ile Val 
            420                 425                 430         


Glu Cys Gln Pro Gly Pro Pro Gly Asp Gln Gly Pro Pro Gly Ile Pro 
        435                 440                 445             


Gly Gln Pro Gly Phe Ile Gly Glu Ile Gly Glu Lys Gly Gln Lys Gly 
    450                 455                 460                 


Glu Ser Cys Leu Ile Cys Asp Ile Asp Gly Tyr Arg Gly Pro Pro Gly 
465                 470                 475                 480 


Pro Gln Gly Pro Pro Gly Glu Ile Gly Phe Pro Gly Gln Pro Gly Ala 
                485                 490                 495     


Lys Gly Asp Arg Gly Leu Pro Gly Arg Asp Gly Val Ala Gly Val Pro 
            500                 505                 510         


Gly Pro Gln Gly Thr Pro Gly Leu Ile Gly Gln Pro Gly Ala Lys Gly 
        515                 520                 525             


Glu Pro Gly Glu Phe Tyr Phe Asp Leu Arg Leu Lys Gly Asp Lys Gly 
    530                 535                 540                 


Asp Pro Gly Phe Pro Gly Gln Pro Gly Met Thr Gly Arg Ala Gly Ser 
545                 550                 555                 560 


Pro Gly Arg Asp Gly His Pro Gly Leu Pro Gly Pro Lys Gly Ser Pro 
                565                 570                 575     


Gly Ser Val Gly Leu Lys Gly Glu Arg Gly Pro Pro Gly Gly Val Gly 
            580                 585                 590         


Phe Pro Gly Ser Arg Gly Asp Thr Gly Pro Pro Gly Pro Pro Gly Tyr 
        595                 600                 605             


Gly Pro Ala Gly Pro Ile Gly Asp Lys Gly Gln Ala Gly Phe Pro Gly 
    610                 615                 620                 


Gly Pro Gly Ser Pro Gly Leu Pro Gly Pro Lys Gly Glu Pro Gly Lys 
625                 630                 635                 640 


Ile Val Pro Leu Pro Gly Pro Pro Gly Ala Glu Gly Leu Pro Gly Ser 
                645                 650                 655     


Pro Gly Phe Pro Gly Pro Gln Gly Asp Arg Gly Phe Pro Gly Thr Pro 
            660                 665                 670         


Gly Arg Pro Gly Leu Pro Gly Glu Lys Gly Ala Val Gly Gln Pro Gly 
        675                 680                 685             


Ile Gly Phe Pro Gly Pro Pro Gly Pro Lys Gly Val Asp Gly Leu Pro 
    690                 695                 700                 


Gly Asp Met Gly Pro Pro Gly Thr Pro Gly Arg Pro Gly Phe Asn Gly 
705                 710                 715                 720 


Leu Pro Gly Asn Pro Gly Val Gln Gly Gln Lys Gly Glu Pro Gly Val 
                725                 730                 735     


Gly Leu Pro Gly Leu Lys Gly Leu Pro Gly Leu Pro Gly Ile Pro Gly 
            740                 745                 750         


Thr Pro Gly Glu Lys Gly Ser Ile Gly Val Pro Gly Val Pro Gly Glu 
        755                 760                 765             


His Gly Ala Ile Gly Pro Pro Gly Leu Gln Gly Ile Arg Gly Glu Pro 
    770                 775                 780                 


Gly Pro Pro Gly Leu Pro Gly Ser Val Gly Ser Pro Gly Val Pro Gly 
785                 790                 795                 800 


Ile Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Gly Gln Gly Pro Pro 
                805                 810                 815     


Gly Leu Ser Gly Pro Pro Gly Ile Lys Gly Glu Lys Gly Phe Pro Gly 
            820                 825                 830         


Phe Pro Gly Leu Asp Met Pro Gly Pro Lys Gly Asp Lys Gly Ala Gln 
        835                 840                 845             


Gly Leu Pro Gly Ile Thr Gly Gln Ser Gly Leu Pro Gly Leu Pro Gly 
    850                 855                 860                 


Gln Gln Gly Ala Pro Gly Ile Pro Gly Phe Pro Gly Ser Lys Gly Glu 
865                 870                 875                 880 


Met Gly Val Met Gly Thr Pro Gly Gln Pro Gly Ser Pro Gly Pro Val 
                885                 890                 895     


Gly Ala Pro Gly Leu Pro Gly Glu Lys Gly Asp His Gly Phe Pro Gly 
            900                 905                 910         


Ser Ser Gly Pro Arg Gly Asp Pro Gly Leu Lys Gly Asp Lys Gly Asp 
        915                 920                 925             


Val Gly Leu Pro Gly Lys Pro Gly Ser Met Asp Lys Val Asp Met Gly 
    930                 935                 940                 


Ser Met Lys Gly Gln Lys Gly Asp Gln Gly Glu Lys Gly Gln Ile Gly 
945                 950                 955                 960 


Pro Ile Gly Glu Lys Gly Ser Arg Gly Asp Pro Gly Thr Pro Gly Val 
                965                 970                 975     


Pro Gly Lys Asp Gly Gln Ala Gly Gln Pro Gly Gln Pro Gly Pro Lys 
            980                 985                 990         


Gly Asp Pro Gly Ile Ser Gly Thr  Pro Gly Ala Pro Gly  Leu Pro Gly 
        995                 1000                 1005             


Pro Lys  Gly Ser Val Gly Gly  Met Gly Leu Pro Gly  Thr Pro Gly 
    1010                 1015                 1020             


Glu Lys  Gly Val Pro Gly Ile  Pro Gly Pro Gln Gly  Ser Pro Gly 
    1025                 1030                 1035             


Leu Pro  Gly Asp Lys Gly Ala  Lys Gly Glu Lys Gly  Gln Ala Gly 
    1040                 1045                 1050             


Pro Pro  Gly Ile Gly Ile Pro  Gly Leu Arg Gly Glu  Lys Gly Asp 
    1055                 1060                 1065             


Gln Gly  Ile Ala Gly Phe Pro  Gly Ser Pro Gly Glu  Lys Gly Glu 
    1070                 1075                 1080             


Lys Gly  Ser Ile Gly Ile Pro  Gly Met Pro Gly Ser  Pro Gly Leu 
    1085                 1090                 1095             


Lys Gly  Ser Pro Gly Ser Val  Gly Tyr Pro Gly Ser  Pro Gly Leu 
    1100                 1105                 1110             


Pro Gly  Glu Lys Gly Asp Lys  Gly Leu Pro Gly Leu  Asp Gly Ile 
    1115                 1120                 1125             


Pro Gly  Val Lys Gly Glu Ala  Gly Leu Pro Gly Thr  Pro Gly Pro 
    1130                 1135                 1140             


Thr Gly  Pro Ala Gly Gln Lys  Gly Glu Pro Gly Ser  Asp Gly Ile 
    1145                 1150                 1155             


Pro Gly  Ser Ala Gly Glu Lys  Gly Glu Pro Gly Leu  Pro Gly Arg 
    1160                 1165                 1170             


Gly Phe  Pro Gly Phe Pro Gly  Ala Lys Gly Asp Lys  Gly Ser Lys 
    1175                 1180                 1185             


Gly Glu  Val Gly Phe Pro Gly  Leu Ala Gly Ser Pro  Gly Ile Pro 
    1190                 1195                 1200             


Gly Ser  Lys Gly Glu Gln Gly  Phe Met Gly Pro Pro  Gly Pro Gln 
    1205                 1210                 1215             


Gly Gln  Pro Gly Leu Pro Gly  Ser Pro Gly His Ala  Thr Glu Gly 
    1220                 1225                 1230             


Pro Lys  Gly Asp Arg Gly Pro  Gln Gly Gln Pro Gly  Leu Pro Gly 
    1235                 1240                 1245             


Leu Pro  Gly Pro Met Gly Pro  Pro Gly Leu Pro Gly  Ile Asp Gly 
    1250                 1255                 1260             


Val Lys  Gly Asp Lys Gly Asn  Pro Gly Trp Pro Gly  Ala Pro Gly 
    1265                 1270                 1275             


Val Pro  Gly Pro Lys Gly Asp  Pro Gly Phe Gln Gly  Met Pro Gly 
    1280                 1285                 1290             


Ile Gly  Gly Ser Pro Gly Ile  Thr Gly Ser Lys Gly  Asp Met Gly 
    1295                 1300                 1305             


Pro Pro  Gly Val Pro Gly Phe  Gln Gly Pro Lys Gly  Leu Pro Gly 
    1310                 1315                 1320             


Leu Gln  Gly Ile Lys Gly Asp  Gln Gly Asp Gln Gly  Val Pro Gly 
    1325                 1330                 1335             


Ala Lys  Gly Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Tyr Asp 
    1340                 1345                 1350             


Ile Ile  Lys Gly Glu Pro Gly  Leu Pro Gly Pro Glu  Gly Pro Pro 
    1355                 1360                 1365             


Gly Leu  Lys Gly Leu Gln Gly  Leu Pro Gly Pro Lys  Gly Gln Gln 
    1370                 1375                 1380             


Gly Val  Thr Gly Leu Val Gly  Ile Pro Gly Pro Pro  Gly Ile Pro 
    1385                 1390                 1395             


Gly Phe  Asp Gly Ala Pro Gly  Gln Lys Gly Glu Met  Gly Pro Ala 
    1400                 1405                 1410             


Gly Pro  Thr Gly Pro Arg Gly  Phe Pro Gly Pro Pro  Gly Pro Asp 
    1415                 1420                 1425             


Gly Leu  Pro Gly Ser Met Gly  Pro Pro Gly Thr Pro  Ser Val Asp 
    1430                 1435                 1440             


His Gly  Phe Leu Val Thr Arg  His Ser Gln Thr Ile  Asp Asp Pro 
    1445                 1450                 1455             


Gln Cys  Pro Ser Gly Thr Lys  Ile Leu Tyr His Gly  Tyr Ser Leu 
    1460                 1465                 1470             


Leu Tyr  Val Gln Gly Asn Glu  Arg Ala His Gly Gln  Asp Leu Gly 
    1475                 1480                 1485             


Thr Ala  Gly Ser Cys Leu Arg  Lys Phe Ser Thr Met  Pro Phe Leu 
    1490                 1495                 1500             


Phe Cys  Asn Ile Asn Asn Val  Cys Asn Phe Ala Ser  Arg Asn Asp 
    1505                 1510                 1515             


Tyr Ser  Tyr Trp Leu Ser Thr  Pro Glu Pro Met Pro  Met Ser Met 
    1520                 1525                 1530             


Ala Pro  Ile Thr Gly Glu Asn  Ile Arg Pro Phe Ile  Ser Arg Cys 
    1535                 1540                 1545             


Ala Val  Cys Glu Ala Pro Ala  Met Val Met Ala Val  His Ser Gln 
    1550                 1555                 1560             


Thr Ile  Gln Ile Pro Pro Cys  Pro Ser Gly Trp Ser  Ser Leu Trp 
    1565                 1570                 1575             


Ile Gly  Tyr Ser Phe Val Met  His Thr Ser Ala Gly  Ala Glu Gly 
    1580                 1585                 1590             


Ser Gly  Gln Ala Leu Ala Ser  Pro Gly Ser Cys Leu  Glu Glu Phe 
    1595                 1600                 1605             


Arg Ser  Ala Pro Phe Ile Glu  Cys His Gly Arg Gly  Thr Cys Asn 
    1610                 1615                 1620             


Tyr Tyr  Ala Asn Ala Tyr Ser  Phe Trp Leu Ala Thr  Ile Glu Arg 
    1625                 1630                 1635             


Ser Glu  Met Phe Lys Lys Pro  Thr Pro Ser Thr Leu  Lys Ala Gly 
    1640                 1645                 1650             


Glu Leu  Arg Thr His Val Ser  Arg Cys Gln Val Cys  Met Arg Arg 
    1655                 1660                 1665             


Thr 
    


<210>  15
<211>  2582
<212>  DNA
<213>  Homo Sapien

<400>  15
agcgttgttt ttccttggca gctgcggaga cccgtgataa ttcgttaact aattcaacaa       60

acgggaccct tctgtgtgcc agaaaccgca agcagttgct aacccagtgg gacaggcgga      120

ttggaagagc gggaaggtcc tggcccagag cagtgtggtg agcgctgtgc tggaagggaa      180

tgcgggcagt gggtacttgg tagagcactg actgcctccg gccagaggac ttcccggagg      240

aggtgaccca tgagctggag tggtcagagg aaggctggca aaagggcatc gtggacagag      300

gaacagccta tgtgagtggg agcagagacc ttggccaatg ccattcctta tggccttgta      360

gtggaagcaa ggtgatgggg aaggaacact gtaggggata gctgtccacg gacgctgtct      420

acaagaccct ggagtgagat aacgtgcctg gtactgtgcc ctgcatgtgt aagatgccca      480

gttgaccttc gcagcaggag cctggatcag ggcacttcct gcctcaggta ttgctggaca      540

gcccagacac ttccctctgt gaccatgaaa ctctgggtgt ctgcattgct gatggcctgg      600

tttggtgtcc tgagctgtgt gcaggccgaa ttcttcacct ctattgggca catgactgac      660

ctgatttatg cagagaaaga gctggtgcag tctctgaaag agtacatcct tgtggaggaa      720

gccaagcttt ccaagattaa gagctgggcc aacaaaatgg aagccttgac tagcaagtca      780

gctgctgatg ctgagggcta cctggctcac cctgtgaatg cctacaaact ggtgaagcgg      840

ctaaacacag actggcctgc gctggaggac cttgtcctgc aggactcagc tgcaggtttt      900

atcgccaacc tctctgtgca gcggcagttc ttccccactg atgaggacga gataggagct      960

gccaaagccc tgatgagact tcaggacaca tacaggctgg acccaggcac aatttccaga     1020

ggggaacttc caggaaccaa gtaccaggca atgctgagtg tggatgactg ctttgggatg     1080

ggccgctcgg cctacaatga aggggactat tatcatacgg tgttgtggat ggagcaggtg     1140

ctaaagcagc ttgatgccgg ggaggaggcc accacaacca agtcacaggt gctggactac     1200

ctcagctatg ctgtcttcca gttgggtgat ctgcaccgtg ccctggagct cacccgccgc     1260

ctgctctccc ttgacccaag ccacgaacga gctggaggga atctgcggta ctttgagcag     1320

ttattggagg aagagagaga aaaaacgtta acaaatcaga cagaagctga gctagcaacc     1380

ccagaaggca tctatgagag gcctgtggac tacctgcctg agagggatgt ttacgagagc     1440

ctctgtcgtg gggagggtgt caaactgaca ccccgtagac agaagaggct tttctgtagg     1500

taccaccatg gcaacagggc cccacagctg ctcattgccc ccttcaaaga ggaggacgag     1560

tgggacagcc cgcacatcgt caggtactac gatgtcatgt ctgatgagga aatcgagagg     1620

atcaaggaga tcgcaaaacc taaacttgca cgagccaccg ttcgtgatcc caagacagga     1680

gtcctcactg tcgccagcta ccgggtttcc aaaagctcct ggctagagga agatgatgac     1740

cctgttgtgg cccgagtaaa tcgtcggatg cagcatatca cagggttaac agtaaagact     1800

gcagaattgt tacaggttgc aaattatgga gtgggaggac agtatgaacc gcacttcgac     1860

ttctctaggc gaccttttga cagcggcctc aaaacagagg ggaataggtt agcgacgttt     1920

cttaactaca tgagtgatgt agaagctggt ggtgccaccg tcttccctga tctgggggct     1980

gcaatttggc ctaagaaggg tacagctgtg ttctggtaca acctcttgcg gagcggggaa     2040

ggtgactacc gaacaagaca tgctgcctgc cctgtgcttg tgggctgcaa gtgggtctcc     2100

aataagtggt tccatgaacg aggacaggag ttcttgagac cttgtggatc aacagaagtt     2160

gactgacatc cttttctgtc cttccccttc ctggtccttc agcccatgtc aacgtgacag     2220

acacctttgt atgttccttt gtatgttcct atcaggctga tttttggaga aatgaatgtt     2280

tgtctggagc agagggagac catactaggg cgactcctgt gtgactgaag tcccagccct     2340

tccattcagc ctgtgccatc cctggcccca aggctaggat caaagtggct gcagcagagt     2400

tagctgtcta gcgcctagca aggtgccttt gtacctcagg tgttttaggt gtgagatgtt     2460

tcagtgaacc aaagttctga taccttgttt acatgtttgt ttttatggca tttctatcta     2520

ttgtggcttt accaaaaaat aaaatgtccc taccagaagc cttaaaaaaa aaaaaaaaaa     2580

aa                                                                    2582


<210>  16
<211>  535
<212>  PRT
<213>  Homo Sapien

<400>  16

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
            180                 185                 190         


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr Thr Lys Ser Gln 
        195                 200                 205             


Val Leu Asp Tyr Leu Ser Tyr Ala Val Phe Gln Leu Gly Asp Leu His 
    210                 215                 220                 


Arg Ala Leu Glu Leu Thr Arg Arg Leu Leu Ser Leu Asp Pro Ser His 
225                 230                 235                 240 


Glu Arg Ala Gly Gly Asn Leu Arg Tyr Phe Glu Gln Leu Leu Glu Glu 
                245                 250                 255     


Glu Arg Glu Lys Thr Leu Thr Asn Gln Thr Glu Ala Glu Leu Ala Thr 
            260                 265                 270         


Pro Glu Gly Ile Tyr Glu Arg Pro Val Asp Tyr Leu Pro Glu Arg Asp 
        275                 280                 285             


Val Tyr Glu Ser Leu Cys Arg Gly Glu Gly Val Lys Leu Thr Pro Arg 
    290                 295                 300                 


Arg Gln Lys Arg Leu Phe Cys Arg Tyr His His Gly Asn Arg Ala Pro 
305                 310                 315                 320 


Gln Leu Leu Ile Ala Pro Phe Lys Glu Glu Asp Glu Trp Asp Ser Pro 
                325                 330                 335     


His Ile Val Arg Tyr Tyr Asp Val Met Ser Asp Glu Glu Ile Glu Arg 
            340                 345                 350         


Ile Lys Glu Ile Ala Lys Pro Lys Leu Ala Arg Ala Thr Val Arg Asp 
        355                 360                 365             


Pro Lys Thr Gly Val Leu Thr Val Ala Ser Tyr Arg Val Ser Lys Ser 
    370                 375                 380                 


Ser Trp Leu Glu Glu Asp Asp Asp Pro Val Val Ala Arg Val Asn Arg 
385                 390                 395                 400 


Arg Met Gln His Ile Thr Gly Leu Thr Val Lys Thr Ala Glu Leu Leu 
                405                 410                 415     


Gln Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp 
            420                 425                 430         


Phe Ser Arg Asn Asp Glu Arg Asp Thr Phe Lys His Leu Gly Thr Gly 
        435                 440                 445             


Asn Arg Val Ala Thr Phe Leu Asn Tyr Met Ser Asp Val Glu Ala Gly 
    450                 455                 460                 


Gly Ala Thr Val Phe Pro Asp Leu Gly Ala Ala Ile Trp Pro Lys Lys 
465                 470                 475                 480 


Gly Thr Ala Val Phe Trp Tyr Asn Leu Leu Arg Ser Gly Glu Gly Asp 
                485                 490                 495     


Tyr Arg Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Cys Lys Trp 
            500                 505                 510         


Val Ser Asn Lys Trp Phe His Glu Arg Gly Gln Glu Phe Leu Arg Pro 
        515                 520                 525             


Cys Gly Ser Thr Glu Val Asp 
    530                 535 


<210>  17
<211>  533
<212>  PRT
<213>  Homo Sapien

<400>  17

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
            180                 185                 190         


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr Thr Lys Ser Gln 
        195                 200                 205             


Val Leu Asp Tyr Leu Ser Tyr Ala Val Phe Gln Leu Gly Asp Leu His 
    210                 215                 220                 


Arg Ala Leu Glu Leu Thr Arg Arg Leu Leu Ser Leu Asp Pro Ser His 
225                 230                 235                 240 


Glu Arg Ala Gly Gly Asn Leu Arg Tyr Phe Glu Gln Leu Leu Glu Glu 
                245                 250                 255     


Glu Arg Glu Lys Thr Leu Thr Asn Gln Thr Glu Ala Glu Leu Ala Thr 
            260                 265                 270         


Pro Glu Gly Ile Tyr Glu Arg Pro Val Asp Tyr Leu Pro Glu Arg Asp 
        275                 280                 285             


Val Tyr Glu Ser Leu Cys Arg Gly Glu Gly Val Lys Leu Thr Pro Arg 
    290                 295                 300                 


Arg Gln Lys Arg Leu Phe Cys Arg Tyr His His Gly Asn Arg Ala Pro 
305                 310                 315                 320 


Gln Leu Leu Ile Ala Pro Phe Lys Glu Glu Asp Glu Trp Asp Ser Pro 
                325                 330                 335     


His Ile Val Arg Tyr Tyr Asp Val Met Ser Asp Glu Glu Ile Glu Arg 
            340                 345                 350         


Ile Lys Glu Ile Ala Lys Pro Lys Leu Ala Arg Ala Thr Val Arg Asp 
        355                 360                 365             


Pro Lys Thr Gly Val Leu Thr Val Ala Ser Tyr Arg Val Ser Lys Ser 
    370                 375                 380                 


Ser Trp Leu Glu Glu Asp Asp Asp Pro Val Val Ala Arg Val Asn Arg 
385                 390                 395                 400 


Arg Met Gln His Ile Thr Gly Leu Thr Val Lys Thr Ala Glu Leu Leu 
                405                 410                 415     


Gln Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp 
            420                 425                 430         


Phe Ser Arg Arg Pro Phe Asp Ser Gly Leu Lys Thr Glu Gly Asn Arg 
        435                 440                 445             


Leu Ala Thr Phe Leu Asn Tyr Met Ser Asp Val Glu Ala Gly Gly Ala 
    450                 455                 460                 


Thr Val Phe Pro Asp Leu Gly Ala Ala Ile Trp Pro Lys Lys Gly Thr 
465                 470                 475                 480 


Ala Val Phe Trp Tyr Asn Leu Leu Arg Ser Gly Glu Gly Asp Tyr Arg 
                485                 490                 495     


Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Cys Lys Trp Val Ser 
            500                 505                 510         


Asn Lys Trp Phe His Glu Arg Gly Gln Glu Phe Leu Arg Pro Cys Gly 
        515                 520                 525             


Ser Thr Glu Val Asp 
    530             


<210>  18
<211>  5826
<212>  DNA
<213>  Homo Sapien

<400>  18
gaggaggaga cggcatccag tacagagggg ctggacttgg acccctgcag cagccctgca       60

caggagaagc ggcatataaa gccgcgctgc ccgggagccg ctcggccacg tccaccggag      120

catcctgcac tgcagggccg gtctctcgct ccagcagagc ctgcgccttt ctgactcggt      180

ccggaacact gaaaccagtc atcactgcat ctttttggca aaccaggagc tcagctgcag      240

gaggcaggat ggtctggagg ctggtcctgc tggctctgtg ggtgtggccc agcacgcaag      300

ctggtcacca ggacaaagac acgaccttcg accttttcag tatcagcaac atcaaccgca      360

agaccattgg cgccaagcag ttccgcgggc ccgaccccgg cgtgccggct taccgcttcg      420

tgcgctttga ctacatccca ccggtgaacg cagatgacct cagcaagatc accaagatca      480

tgcggcagaa ggagggcttc ttcctcacgg cccagctcaa gcaggacggc aagtccaggg      540

gcacgctgtt ggctctggag ggccccggtc tctcccagag gcagttcgag atcgtctcca      600

acggccccgc ggacacgctg gatctcacct actggattga cggcacccgg catgtggtct      660

ccctggagga cgtcggcctg gctgactcgc agtggaagaa cgtcaccgtg caggtggctg      720

gcgagaccta cagcttgcac gtgggctgcg acctcataga cagcttcgct ctggacgagc      780

ccttctacga gcacctgcag gcggaaaaga gccggatgta cgtggccaaa ggctctgcca      840

gagagagtca cttcaggggt ttgcttcaga acgtccacct agtgtttgaa aactctgtgg      900

aagatattct aagcaagaag ggttgccagc aaggccaggg agctgagatc aacgccatca      960

gtgagaacac agagacgctg cgcctgggtc cgcatgtcac caccgagtac gtgggcccca     1020

gctcggagag gaggcccgag gtgtgcgaac gctcgtgcga ggagctggga aacatggtcc     1080

aggagctctc ggggctccac gtcctcgtga accagctcag cgagaacctc aagagagtgt     1140

cgaatgataa ccagtttctc tgggagctca ttggtggccc tcctaagaca aggaacatgt     1200

cagcttgctg gcaggatggc cggttctttg cggaaaatga aacgtgggtg gtggacagct     1260

gcaccacgtg tacctgcaag aaatttaaaa ccatttgcca ccaaatcacc tgcccgcctg     1320

caacctgcgc cagtccatcc tttgtggaag gcgaatgctg cccttcctgc ctccactcgg     1380

tggacggtga ggagggctgg tctccgtggg cagagtggac ccagtgctcc gtgacgtgtg     1440

gctctgggac ccagcagaga ggccggtcct gtgacgtcac cagcaacacc tgcttggggc     1500

cctccatcca gacacgggct tgcagtctga gcaagtgtga cacccgcatc cggcaggacg     1560

gcggctggag ccactggtca ccttggtctt catgctctgt gacctgtgga gttggcaata     1620

tcacacgcat ccgtctctgc aactccccag tgccccagat ggggggcaag aattgcaaag     1680

ggagtggccg ggagaccaaa gcctgccagg gcgccccatg cccaatcgat ggccgctgga     1740

gcccctggtc cccgtggtcg gcctgcactg tcacctgtgc cggtgggatc cgggagcgca     1800

cccgggtctg caacagccct gagcctcagt acggagggaa ggcctgcgtg ggggatgtgc     1860

aggagcgtca gatgtgcaac aagaggagct gccccgtgga tggctgttta tccaacccct     1920

gcttcccggg agcccagtgc agcagcttcc ccgatgggtc ctggtcatgc ggctcctgcc     1980

ctgtgggctt cttgggcaat ggcacccact gtgaggacct ggacgagtgt gccctggtcc     2040

ccgacatctg cttctccacc agcaaggtgc ctcgctgtgt caacactcag cctggcttcc     2100

actgcctgcc ctgcccgccc cgatacagag ggaaccagcc cgtcggggtc ggcctggaag     2160

cagccaagac ggaaaagcaa gtgtgtgagc ccgaaaaccc atgcaaggac aagacacaca     2220

actgccacaa gcacgcggag tgcatctacc tgggccactt cagcgacccc atgtacaagt     2280

gcgagtgcca gacaggctac gcgggcgacg ggctcatctg cggggaggac tcggacctgg     2340

acggctggcc caacctcaat ctggtctgcg ccaccaacgc cacctaccac tgcatcaagg     2400

ataactgccc ccatctgcca aattctgggc aggaagactt tgacaaggac gggattggcg     2460

atgcctgtga tgatgacgat gacaatgacg gtgtgaccga tgagaaggac aactgccagc     2520

tcctcttcaa tccccgccag gctgactatg acaaggatga ggttggggac cgctgtgaca     2580

actgccctta cgtgcacaac cctgcccaga tcgacacaga caacaatgga gagggtgacg     2640

cctgctccgt ggacattgat ggggacgatg tcttcaatga acgagacaat tgtccctacg     2700

tctacaacac tgaccagagg gacacggatg gtgacggtgt gggggatcac tgtgacaact     2760

gccccctggt gcacaaccct gaccagaccg acgtggacaa tgaccttgtt ggggaccagt     2820

gtgacaacaa cgaggacata gatgacgacg gccaccagaa caaccaggac aactgcccct     2880

acatctccaa cgccaaccag gctgaccatg acagagacgg ccagggcgac gcctgtgacc     2940

ctgatgatga caacgatggc gtccccgatg acagggacaa ctgccggctt gtgttcaacc     3000

cagaccagga ggacttggac ggtgatggac ggggtgatat ttgtaaagat gattttgaca     3060

atgacaacat cccagatatt gatgatgtgt gtcctgaaaa caatgccatc agtgagacag     3120

acttcaggaa cttccagatg gtccccttgg atcccaaagg gaccacccaa attgatccca     3180

actgggtcat tcgccatcaa ggcaaggagc tggttcagac agccaactcg gaccccggca     3240

tcgctgtagg ttttgacgag tttgggtctg tggacttcag tggcacattc tacgtaaaca     3300

ctgaccggga cgacgactat gccggcttcg tctttggtta ccagtcaagc agccgcttct     3360

atgtggtgat gtggaagcag gtgacgcaga cctactggga ggaccagccc acgcgggcct     3420

atggctactc cggcgtgtcc ctcaaggtgg tgaactccac cacggggacg ggcgagcacc     3480

tgaggaacgc gctgtggcac acggggaaca cgccggggca ggtgcgaacc ttatggcacg     3540

accccaggaa cattggctgg aaggactaca cggcctatag gtggcacctg actcacaggc     3600

ccaagactgg ctacatcaga gtcttagtgc atgaaggaaa acaggtcatg gcagactcag     3660

gacctatcta tgaccaaacc tacgctggcg ggcggctggg tctatttgtc ttctctcaag     3720

aaatggtcta tttctcagac ctcaagtacg aatgcagaga tatttaaaca agatttgctg     3780

catttccggc aatgccctgt gcatgccatg gtccctagac acctcagttc attgtggtcc     3840

ttgtggcttc tctctctagc agcacctcct gtcccttgac cttaactctg atggttcttc     3900

acctcctgcc agcaacccca aacccaagtg ccttcagagg ataaatatca atggaactca     3960

gagatgaaca tctaacccac tagaggaaac cagtttggtg atatatgaga ctttatgtgg     4020

agtgaaaatt gggcatgcca ttacattgct ttttcttgtt tgtttaaaaa gaatgacgtt     4080

tacatataaa atgtaattac ttattgtatt tatgtgtata tggagttgaa gggaatactg     4140

tgcataagcc attatgataa attaagcatg aaaaatattg ctgaactact tttggtgctt     4200

aaagttgtca ctattcttga attagagttg ctctacaatg acacacaaat cccattaaat     4260

aaattataaa caagggtcaa ttcaaatttg aagtaatgtt ttagtaagga gagattagaa     4320

gacaacaggc atagcaaatg acataagcta ccgattaact aatcggaaca tgtaaaacag     4380

ttacaaaaat aaacgaactc tcctcttgtc ctacaatgaa agccctcatg tgcagtagag     4440

atgcagtttc atcaaagaac aaacatcctt gcaaatgggt gtgacgcggt tccagatgtg     4500

gatttggcaa aacctcattt aagtaaaagg ttagcagagc aaagtgcggt gctttagctg     4560

ctgcttgtgc cgctgtggcg tcggggaggc tcctgcctga gcttccttcc ccagctttgc     4620

tgcctgagag gaaccagagc agacgcacag gccggaaaag gcgcatctaa cgcgtatcta     4680

ggctttggta actgcggaca agttgctttt acctgatttg atgatacatt tcattaaggt     4740

tccagttata aatattttgt taatatttat taagtgacta tagaatgcaa ctccatttac     4800

cagtaactta ttttaaatat gcctagtaac acatatgtag tataatttct agaaacaaac     4860

atctaataag tatataatcc tgtgaaaata tgaggcttga taatattagg ttgtcacgat     4920

gaagcatgct agaagctgta acagaataca tagagaataa tgaggagttt atgatggaac     4980

cttaaatata taatgttgcc agcgatttta gttcaatatt tgttactgtt atctatctgc     5040

tgtatatgga attcttttaa ttcaaacgct gaaaagaatc agcatttagt cttgccaggc     5100

acacccaata atcagtcatg tgtaatatgc acaagtttgt ttttgttttt gttttttttg     5160

ttggttggtt tgtttttttg ctttaagttg catgatcttt ctgcaggaaa tagtcactca     5220

tcccactcca cataaggggt ttagtaagag aagtctgtct gtctgatgat ggataggggg     5280

caaatctttt tcccctttct gttaatagtc atcacatttc tatgccaaac aggaacaatc     5340

cataacttta gtcttaatgt acacattgca ttttgataaa attaattttg ttgtttcctt     5400

tgaggttgat cgttgtgttg ttgttttgct gcacttttta cttttttgcg tgtggagctg     5460

tattcccgag accaacgaag cgttgggata cttcattaaa tgtagcgact gtcaacagcg     5520

tgcaggtttt ctgtttctgt gttgtggggt caaccgtaca atggtgtggg agtgacgatg     5580

atgtgaatat ttagaatgta ccatattttt tgtaaattat ttatgttttt ctaaacaaat     5640

ttatcgtata ggttgatgaa acgtcatgtg ttttgccaaa gactgtaaat atttatttat     5700

gtgttcacat ggtcaaaatt tcaccactga aaccctgcac ttagctagaa cctcattttt     5760

aaagattaac aacaggaaat aaattgtaaa aaaggttttc tatacatgaa aaaaaaaaaa     5820

aaaaaa                                                                5826


<210>  19
<211>  1172
<212>  PRT
<213>  Homo Sapien

<400>  19

Met Val Trp Arg Leu Val Leu Leu Ala Leu Trp Val Trp Pro Ser Thr 
1               5                   10                  15      


Gln Ala Gly His Gln Asp Lys Asp Thr Thr Phe Asp Leu Phe Ser Ile 
            20                  25                  30          


Ser Asn Ile Asn Arg Lys Thr Ile Gly Ala Lys Gln Phe Arg Gly Pro 
        35                  40                  45              


Asp Pro Gly Val Pro Ala Tyr Arg Phe Val Arg Phe Asp Tyr Ile Pro 
    50                  55                  60                  


Pro Val Asn Ala Asp Asp Leu Ser Lys Ile Thr Lys Ile Met Arg Gln 
65                  70                  75                  80  


Lys Glu Gly Phe Phe Leu Thr Ala Gln Leu Lys Gln Asp Gly Lys Ser 
                85                  90                  95      


Arg Gly Thr Leu Leu Ala Leu Glu Gly Pro Gly Leu Ser Gln Arg Gln 
            100                 105                 110         


Phe Glu Ile Val Ser Asn Gly Pro Ala Asp Thr Leu Asp Leu Thr Tyr 
        115                 120                 125             


Trp Ile Asp Gly Thr Arg His Val Val Ser Leu Glu Asp Val Gly Leu 
    130                 135                 140                 


Ala Asp Ser Gln Trp Lys Asn Val Thr Val Gln Val Ala Gly Glu Thr 
145                 150                 155                 160 


Tyr Ser Leu His Val Gly Cys Asp Leu Ile Asp Ser Phe Ala Leu Asp 
                165                 170                 175     


Glu Pro Phe Tyr Glu His Leu Gln Ala Glu Lys Ser Arg Met Tyr Val 
            180                 185                 190         


Ala Lys Gly Ser Ala Arg Glu Ser His Phe Arg Gly Leu Leu Gln Asn 
        195                 200                 205             


Val His Leu Val Phe Glu Asn Ser Val Glu Asp Ile Leu Ser Lys Lys 
    210                 215                 220                 


Gly Cys Gln Gln Gly Gln Gly Ala Glu Ile Asn Ala Ile Ser Glu Asn 
225                 230                 235                 240 


Thr Glu Thr Leu Arg Leu Gly Pro His Val Thr Thr Glu Tyr Val Gly 
                245                 250                 255     


Pro Ser Ser Glu Arg Arg Pro Glu Val Cys Glu Arg Ser Cys Glu Glu 
            260                 265                 270         


Leu Gly Asn Met Val Gln Glu Leu Ser Gly Leu His Val Leu Val Asn 
        275                 280                 285             


Gln Leu Ser Glu Asn Leu Lys Arg Val Ser Asn Asp Asn Gln Phe Leu 
    290                 295                 300                 


Trp Glu Leu Ile Gly Gly Pro Pro Lys Thr Arg Asn Met Ser Ala Cys 
305                 310                 315                 320 


Trp Gln Asp Gly Arg Phe Phe Ala Glu Asn Glu Thr Trp Val Val Asp 
                325                 330                 335     


Ser Cys Thr Thr Cys Thr Cys Lys Lys Phe Lys Thr Ile Cys His Gln 
            340                 345                 350         


Ile Thr Cys Pro Pro Ala Thr Cys Ala Ser Pro Ser Phe Val Glu Gly 
        355                 360                 365             


Glu Cys Cys Pro Ser Cys Leu His Ser Val Asp Gly Glu Glu Gly Trp 
    370                 375                 380                 


Ser Pro Trp Ala Glu Trp Thr Gln Cys Ser Val Thr Cys Gly Ser Gly 
385                 390                 395                 400 


Thr Gln Gln Arg Gly Arg Ser Cys Asp Val Thr Ser Asn Thr Cys Leu 
                405                 410                 415     


Gly Pro Ser Ile Gln Thr Arg Ala Cys Ser Leu Ser Lys Cys Asp Thr 
            420                 425                 430         


Arg Ile Arg Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser 
        435                 440                 445             


Cys Ser Val Thr Cys Gly Val Gly Asn Ile Thr Arg Ile Arg Leu Cys 
    450                 455                 460                 


Asn Ser Pro Val Pro Gln Met Gly Gly Lys Asn Cys Lys Gly Ser Gly 
465                 470                 475                 480 


Arg Glu Thr Lys Ala Cys Gln Gly Ala Pro Cys Pro Ile Asp Gly Arg 
                485                 490                 495     


Trp Ser Pro Trp Ser Pro Trp Ser Ala Cys Thr Val Thr Cys Ala Gly 
            500                 505                 510         


Gly Ile Arg Glu Arg Thr Arg Val Cys Asn Ser Pro Glu Pro Gln Tyr 
        515                 520                 525             


Gly Gly Lys Ala Cys Val Gly Asp Val Gln Glu Arg Gln Met Cys Asn 
    530                 535                 540                 


Lys Arg Ser Cys Pro Val Asp Gly Cys Leu Ser Asn Pro Cys Phe Pro 
545                 550                 555                 560 


Gly Ala Gln Cys Ser Ser Phe Pro Asp Gly Ser Trp Ser Cys Gly Ser 
                565                 570                 575     


Cys Pro Val Gly Phe Leu Gly Asn Gly Thr His Cys Glu Asp Leu Asp 
            580                 585                 590         


Glu Cys Ala Leu Val Pro Asp Ile Cys Phe Ser Thr Ser Lys Val Pro 
        595                 600                 605             


Arg Cys Val Asn Thr Gln Pro Gly Phe His Cys Leu Pro Cys Pro Pro 
    610                 615                 620                 


Arg Tyr Arg Gly Asn Gln Pro Val Gly Val Gly Leu Glu Ala Ala Lys 
625                 630                 635                 640 


Thr Glu Lys Gln Val Cys Glu Pro Glu Asn Pro Cys Lys Asp Lys Thr 
                645                 650                 655     


His Asn Cys His Lys His Ala Glu Cys Ile Tyr Leu Gly His Phe Ser 
            660                 665                 670         


Asp Pro Met Tyr Lys Cys Glu Cys Gln Thr Gly Tyr Ala Gly Asp Gly 
        675                 680                 685             


Leu Ile Cys Gly Glu Asp Ser Asp Leu Asp Gly Trp Pro Asn Leu Asn 
    690                 695                 700                 


Leu Val Cys Ala Thr Asn Ala Thr Tyr His Cys Ile Lys Asp Asn Cys 
705                 710                 715                 720 


Pro His Leu Pro Asn Ser Gly Gln Glu Asp Phe Asp Lys Asp Gly Ile 
                725                 730                 735     


Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Thr Asp Glu 
            740                 745                 750         


Lys Asp Asn Cys Gln Leu Leu Phe Asn Pro Arg Gln Ala Asp Tyr Asp 
        755                 760                 765             


Lys Asp Glu Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Val His Asn 
    770                 775                 780                 


Pro Ala Gln Ile Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ser 
785                 790                 795                 800 


Val Asp Ile Asp Gly Asp Asp Val Phe Asn Glu Arg Asp Asn Cys Pro 
                805                 810                 815     


Tyr Val Tyr Asn Thr Asp Gln Arg Asp Thr Asp Gly Asp Gly Val Gly 
            820                 825                 830         


Asp His Cys Asp Asn Cys Pro Leu Val His Asn Pro Asp Gln Thr Asp 
        835                 840                 845             


Val Asp Asn Asp Leu Val Gly Asp Gln Cys Asp Asn Asn Glu Asp Ile 
    850                 855                 860                 


Asp Asp Asp Gly His Gln Asn Asn Gln Asp Asn Cys Pro Tyr Ile Ser 
865                 870                 875                 880 


Asn Ala Asn Gln Ala Asp His Asp Arg Asp Gly Gln Gly Asp Ala Cys 
                885                 890                 895     


Asp Pro Asp Asp Asp Asn Asp Gly Val Pro Asp Asp Arg Asp Asn Cys 
            900                 905                 910         


Arg Leu Val Phe Asn Pro Asp Gln Glu Asp Leu Asp Gly Asp Gly Arg 
        915                 920                 925             


Gly Asp Ile Cys Lys Asp Asp Phe Asp Asn Asp Asn Ile Pro Asp Ile 
    930                 935                 940                 


Asp Asp Val Cys Pro Glu Asn Asn Ala Ile Ser Glu Thr Asp Phe Arg 
945                 950                 955                 960 


Asn Phe Gln Met Val Pro Leu Asp Pro Lys Gly Thr Thr Gln Ile Asp 
                965                 970                 975     


Pro Asn Trp Val Ile Arg His Gln Gly Lys Glu Leu Val Gln Thr Ala 
            980                 985                 990         


Asn Ser Asp Pro Gly Ile Ala Val  Gly Phe Asp Glu Phe  Gly Ser Val 
        995                 1000                 1005             


Asp Phe  Ser Gly Thr Phe Tyr  Val Asn Thr Asp Arg  Asp Asp Asp 
    1010                 1015                 1020             


Tyr Ala  Gly Phe Val Phe Gly  Tyr Gln Ser Ser Ser  Arg Phe Tyr 
    1025                 1030                 1035             


Val Val  Met Trp Lys Gln Val  Thr Gln Thr Tyr Trp  Glu Asp Gln 
    1040                 1045                 1050             


Pro Thr  Arg Ala Tyr Gly Tyr  Ser Gly Val Ser Leu  Lys Val Val 
    1055                 1060                 1065             


Asn Ser  Thr Thr Gly Thr Gly  Glu His Leu Arg Asn  Ala Leu Trp 
    1070                 1075                 1080             


His Thr  Gly Asn Thr Pro Gly  Gln Val Arg Thr Leu  Trp His Asp 
    1085                 1090                 1095             


Pro Arg  Asn Ile Gly Trp Lys  Asp Tyr Thr Ala Tyr  Arg Trp His 
    1100                 1105                 1110             


Leu Thr  His Arg Pro Lys Thr  Gly Tyr Ile Arg Val  Leu Val His 
    1115                 1120                 1125             


Glu Gly  Lys Gln Val Met Ala  Asp Ser Gly Pro Ile  Tyr Asp Gln 
    1130                 1135                 1140             


Thr Tyr  Ala Gly Gly Arg Leu  Gly Leu Phe Val Phe  Ser Gln Glu 
    1145                 1150                 1155             


Met Val  Tyr Phe Ser Asp Leu  Lys Tyr Glu Cys Arg  Asp Ile 
    1160                 1165                 1170         


<210>  20
<211>  4531
<212>  DNA
<213>  Homo Sapien

<400>  20
tggtcgtcct ccttgggttc gggtgaaagc gcttgggggt tcagtgggcc atgatccccg       60

agctgctgga gaactgaagg cggacagtct cctgcgaaac cagcggagct ggagtttgtt      120

cagatcatca tcatcgtggt ggtgatgatg gtgatggtgg tggtgatcac gtgcctgctg      180

agccactaca agctgtctgc acggtccttc atcagccggc acagccaggg gcggaggaga      240

gaagatgccc tgtcctcaga aggatgcctg tggccctcgg agagcacagt gtcaggcaac      300

ggaatcccag agccgcaggt ctacgccccg cctcggccca ccgaccgcct ggccgtgccg      360

cccttcgccc agcgggagcg cttccaccgc ttccagccca cctatccgta cctgcagcac      420

gagatcgacc tgccacccac catctcgctg tcagacgggg aggagccccc accctaccag      480

ggcccctgca ccctccagct tcgggacccc gagcagcagc tggaactgaa ccgggagtcg      540

gtgcgcgcac ccccaaacag aaccatcttc gacagtgacc tgatggatag tgccaggctg      600

ggcggcccct gcccccccag cagtaactcg ggcatcagcg ccacgtgcta cggcagcggc      660

gggcgcatgg aggggccgcc gcccacctac agcgaggtca tcggccacta cccggggtcc      720

tccttccagc accagcagag cagtgggccg ccctccttgc tggaggggac ccggctccac      780

cacacacaca tcgcgcccct agagagcgca gccatctgga gcaaagagaa ggataaacag      840

aaaggacacc ctctctaggg tccccagggg ggccgggctg gggctgcgta ggtgaaaagg      900

cagaacactc cgcgcttctt agaagaggag tgagaggaag gcggggggcg cagcaacgca      960

tcgtgtggcc ctcccctccc acctccctgt gtataaatat ttacatgtga tgtctggtct     1020

gaatgcacaa gctaagagag cttgcaaaaa aaaaaagaaa aaagaaaaaa aaaaaccacg     1080

tttctttgtt gagctgtgtc ttgaaggcaa aagaaaaaaa atttctacag tagtctttct     1140

tgtttctagt tgagctgcgt gcgtgaatgc ttattttctt ttgtttatga taatttcact     1200

taactttaaa gacatatttg cacaaaacct ttgtttaaag atctgcaata ttatatatat     1260

aaatatatat aagataagag aaactgtatg tgcgagggca ggagtatttt tgtattagaa     1320

gaggcctatt aaaaaaaaaa gttgttttct gaactagaag aggaaaaaaa tggcaatttt     1380

tgagtgccaa gtcagaaagt gtgtattacc ttgtaaagaa aaaaattaca aagcaggggt     1440

ttagagttat ttatataaat gttgagattt tgcactattt tttaatataa atatgtcagt     1500

gcttgcttga tggaaacttc tcttgtgtct gttgagactt taagggagaa atgtcggaat     1560

ttcagagtcg cctgacggca gagggtgagc ccccgtggag tctgcagaga ggccttggcc     1620

aggagcggcg ggctttcccg aggggccact gtccctgcag agtggatgct tctgcctagt     1680

gacaggttat caccacgtta tatattccct accgaaggag acaccttttc ccccctgacc     1740

cagaacagcc tttaaatcac aagcaaaata ggaaagttaa ccacggaggc accgagttcc     1800

aggtagtggt tttgcctttc ccaaaaatga aaataaactg ttaccgaagg aattagtttt     1860

tcctcttctt ttttccaact gtgaaggtcc ccgtggggtg gagcatggtg cccctcacaa     1920

gccgcagcgg ctggtgcccg ggctaccagg gacatgccag agggctcgat gacttgtctc     1980

tgcagggcgc tttggtggtt gttcagctgg ctaaaggttc accggtgaag gcaggtgcgg     2040

taactgccgc actggaccct aggaagcccc aggtattcgc aatctgacct cctcctgtct     2100

gtttcccttc acggatcaat tctcacttaa gaggccaata aacaacccaa catgaaaagg     2160

tgacaagcct gggtttctcc caggataggt gaaagggtta aaatgagtaa agcagttgag     2220

caaacaccaa cccgagcttc gggcgcagaa ttcttcacct tctcttcccc tttccatctc     2280

ctttccccgc ggaaacaacg cttcccttct ggtgtgtctg ttgatctgtg ttttcattta     2340

catctctctt agactccgct cttgttctcc aggttttcac cagatagatt tggggttggc     2400

gggacctgct ggtgacgtgc aggtgaagga caggaagggg catgtgagcg taaatagagg     2460

tgaccagagg agagcatgag gggtggggct ttgggaccca ccggggccag tggctggagc     2520

ttgacgtctt tcctccccat gggggtggga gggcccccag ctggaagagc agactcccag     2580

ctgctacccc ctcccttccc atgggagtgg ctttccattt tgggcagaat gctgactagt     2640

agactaacat aaaagatata aaaggcaata actattgttt gtgagcaact tttttataac     2700

ttccaaaaca aaaacctgag cacagttttg aagttctagc cactcgagct catgcatgtg     2760

aaacgtgtgc tttacgaagg tggcagctga cagacgtggg ctctgcatgc cgccagccta     2820

gtagaaagtt ctcgttcatt ggcaacagca gaacctgcct ctccgtgaag tcgtcagcct     2880

aaaatttgtt tctctcttga agaggattct ttgaaaaggt cctgcagaga aatcagtaca     2940

ggttatcccg aaaggtacaa ggacgcactt gtaaagatga ttaaaacgta tctttccttt     3000

atgtgacgcg tctctagtgc cttactgaag aagcagtgac actcccgtcg ctcggtgagg     3060

acgttcccgg acagtgcctc actcacctgg gactggtatc ccctcccagg gtccaccaag     3120

ggctcctgct tttcagacac cccatcatcc tcgcgcgtcc tcaccctgtc tctaccaggg     3180

aggtgcctag cttggtgagg ttactcctgc tcctccaacc tttttttgcc aaggtttgta     3240

cacgactccc atctaggctg aaaacctaga agtggacctt gtgtgtgtgc atggtgtcag     3300

cccaaagcca ggctgagaca gtcctcatat cctcttgagc caaactgttt gggtctcgtt     3360

gcttcatggt atggtctgga tttgtgggaa tggctttgcg tgagaaaggg gaggagagtg     3420

gttgctgccc tcagccggct tgaggacaga gcctgtccct ctcatgacaa ctcagtgttg     3480

aagcccagtg tcctcagctt catgtccagt ggatggcaga agttcatggg gtagtggcct     3540

ctcaaaggct gggcgcatcc caagacagcc agcaggttgt ctctggaaac gaccagagtt     3600

aagctctcgg cttctctgct gagggtgcac cctttcctct agatggtagt tgtcacgtta     3660

tctttgaaaa ctcttggact gctcctgagg aggccctctt ttccagtagg aagttagatg     3720

ggggttctca gaagtggctg attggaaggg gacaagcttc gtttcagggg tctgccgttc     3780

catcctggtt cagagaaggc cgagcgtggc tttctctagc cttgtcactg tctccctgcc     3840

tgtcaatcac cacctttcct ccagaggagg aaaattatct cccctgcaaa gcccggttct     3900

acacagattt cacaaattgt gctaagaacc gtccgtgttc tcagaaagcc cagtgttttt     3960

gcaaagaatg aaaagggacc ccatatgtag caaaaatcag ggctggggga gagccgggtt     4020

cattccctgt cctcattggt cgtccctatg aattgtacgt ttcagagaaa ttttttttcc     4080

tatgtgcaac acgaagcttc cagaaccata aaatatcccg tcgataagga aagaaaatgt     4140

cgttgttgtt gtttttctgg aaactgcttg aaatcttgct gtactataga gctcagaagg     4200

acacagcccg tcctcccctg cctgcctgat tccatggctg ttgtgctgat tccaatgctt     4260

tcacgttggt tcctggcgtg ggaactgctc tcctttgcag ccccatttcc caagctctgt     4320

tcaagttaaa cttatgtaag ctttccgtgg catgcggggc gcgcacccac gtccccgctg     4380

cgtaagactc tgtatttgga tgccaatcca caggcctgaa gaaactgctt gttgtgtatc     4440

agtaatcatt agtggcaatg atgacattct gaaaagctgc aatacttata caataaattt     4500

tacaattctt tggaaaaaaa aaaaaaaaaa a                                    4531


<210>  21
<211>  237
<212>  PRT
<213>  Homo Sapien

<400>  21

Met Met Val Met Val Val Val Ile Thr Cys Leu Leu Ser His Tyr Lys 
1               5                   10                  15      


Leu Ser Ala Arg Ser Phe Ile Ser Arg His Ser Gln Gly Arg Arg Arg 
            20                  25                  30          


Glu Asp Ala Leu Ser Ser Glu Gly Cys Leu Trp Pro Ser Glu Ser Thr 
        35                  40                  45              


Val Ser Gly Asn Gly Ile Pro Glu Pro Gln Val Tyr Ala Pro Pro Arg 
    50                  55                  60                  


Pro Thr Asp Arg Leu Ala Val Pro Pro Phe Ala Gln Arg Glu Arg Phe 
65                  70                  75                  80  


His Arg Phe Gln Pro Thr Tyr Pro Tyr Leu Gln His Glu Ile Asp Leu 
                85                  90                  95      


Pro Pro Thr Ile Ser Leu Ser Asp Gly Glu Glu Pro Pro Pro Tyr Gln 
            100                 105                 110         


Gly Pro Cys Thr Leu Gln Leu Arg Asp Pro Glu Gln Gln Leu Glu Leu 
        115                 120                 125             


Asn Arg Glu Ser Val Arg Ala Pro Pro Asn Arg Thr Ile Phe Asp Ser 
    130                 135                 140                 


Asp Leu Met Asp Ser Ala Arg Leu Gly Gly Pro Cys Pro Pro Ser Ser 
145                 150                 155                 160 


Asn Ser Gly Ile Ser Ala Thr Cys Tyr Gly Ser Gly Gly Arg Met Glu 
                165                 170                 175     


Gly Pro Pro Pro Thr Tyr Ser Glu Val Ile Gly His Tyr Pro Gly Ser 
            180                 185                 190         


Ser Phe Gln His Gln Gln Ser Ser Gly Pro Pro Ser Leu Leu Glu Gly 
        195                 200                 205             


Thr Arg Leu His His Thr His Ile Ala Pro Leu Glu Ser Ala Ala Ile 
    210                 215                 220                 


Trp Ser Lys Glu Lys Asp Lys Gln Lys Gly His Pro Leu 
225                 230                 235         


<210>  22
<211>  6821
<212>  DNA
<213>  Homo Sapien

<400>  22
gggcgcagtc gggagccggc cgtggtggct ccgtgcgtcc gagcgtccgt ccgcgccgtc       60

ggccatggcc aagcgctcca ggggccccgg gcgccgctgc ctgttggcgc tcgtgctgtt      120

ctgcgcctgg gggacgctgg ccgtggtggc ccagaagccg ggcgcagggt gtccgagccg      180

ctgcctgtgc ttccgcacca ccgtgcgctg catgcatctg ctgctggagg ccgtgcccgc      240

cgtggcgccg cagacctcca tcctagatct tcgctttaac agaatcagag agatccaacc      300

tggggcattc aggcggctga ggaacttgaa cacattgctt ctcaataata atcagatcaa      360

gaggatacct agtggagcat ttgaagactt ggaaaattta aaatatctct atctgtacaa      420

gaatgagatc cagtcaattg acaggcaagc atttaaggga cttgcctctc tagagcaact      480

atacctgcac tttaatcaga tagaaacttt ggacccagat tcgttccagc atctcccgaa      540

gctcgagagg ctatttttgc ataacaaccg gattacacat ttagttccag ggacatttaa      600

tcacttggaa tctatgaaga gattgcgact ggactcaaac acacttcact gcgactgtga      660

aatcctgtgg ttggcggatt tgctgaaaac ctacgcggag tcggggaacg cgcaggcagc      720

ggccatctgt gaatatccca gacgcatcca gggacgctca gtggcaacca tcaccccgga      780

agagctgaac tgtgaaaggc cccggatcac ctccgagccc caggacgcag atgtgacctc      840

ggggaacacc gtgtacttca cctgcagagc cgaaggcaac cccaagcctg agatcatctg      900

gctgcgaaac aataatgagc tgagcatgaa gacagattcc cgcctaaact tgctggacga      960

tgggaccctg atgatccaga acacacagga gacagaccag ggtatctacc agtgcatggc     1020

aaagaacgtg gccggagagg tgaagacgca agaggtgacc ctcaggtact tcgggtctcc     1080

agctcgaccc acttttgtaa tccagccaca gaatacagag gtgctggttg gggagagcgt     1140

cacgctggag tgcagcgcca caggccaccc cccgccgcgg atctcctgga cgagaggtga     1200

ccgcacaccc ttgccagttg acccgcgggt gaacatcacg ccttctggcg ggctttacat     1260

acagaacgtc gtacaggggg acagcggaga gtatgcgtgc tctgcgacca acaacattga     1320

cagcgtccat gccaccgctt tcatcatcgt ccaggctctt cctcagttca ctgtgacgcc     1380

tcaggacaga gtcgttattg agggccagac cgtggatttc cagtgtgaag ccaagggcaa     1440

cccgccgccc gtcatcgcct ggaccaaggg agggagccag ctctccgtgg accggcggca     1500

cctggtcctg tcatcgggaa cacttagaat ctctggtgtt gccctccacg accagggcca     1560

gtacgaatgc caggctgtca acatcatcgg ctcccagaag gtcgtggccc acctgactgt     1620

gcagcccaga gtcaccccag tgtttgccag cattcccagc gacacaacag tggaggtggg     1680

cgccaatgtg cagctcccgt gcagctccca gggcgagccc gagccagcca tcacctggaa     1740

caaggatggg gttcaggtga cagaaagtgg aaaatttcac atcagccctg aaggattctt     1800

gaccatcaat gacgttggcc ctgcagacgc aggtcgctat gagtgtgtgg cccggaacac     1860

cattgggtcg gcctcggtga gcatggtgct cagtgtgaat gttcctgacg tcagtcgaaa     1920

tggagatccg tttgtagcta cctccatcgt ggaagcgatt gcgactgttg acagagctat     1980

aaactcaacc cgaacacatt tgtttgacag ccgtcctcgt tctccaaatg atttgctggc     2040

cttgttccgg tatccgaggg atccttacac agttgaacag gcacgggcgg gagaaatctt     2100

tgaacggaca ttgcagctca ttcaggagca tgtacagcat ggcttgatgg tcgacctcaa     2160

cggaacaagt taccactaca acgacctggt gtctccacag tacctgaacc tcatcgcaaa     2220

cctgtcgggc tgtaccgccc accggcgcgt gaacaactgc tcggacatgt gcttccacca     2280

gaagtaccgg acgcacgacg gcacctgtaa caacctgcag caccccatgt ggggcgcctc     2340

gctgaccgcc ttcgagcgcc tgctgaaatc cgtgtacgag aatggcttca acacccctcg     2400

gggcatcaac ccccaccgac tgtacaacgg gcacgccctt cccatgccgc gcctggtgtc     2460

caccaccctg atcgggacgg agaccgtcac acccgacgag cagttcaccc acatgctgat     2520

gcagtggggc cagttcctgg accacgacct cgactccacg gtggtggccc tgagccaggc     2580

acgcttctcc gacggacagc actgcagcaa cgtgtgcagc aacgaccccc cctgcttctc     2640

tgtcatgatc ccccccaatg actcccgggc caggagcggg gcccgctgca tgttcttcgt     2700

gcgctccagc cctgtgtgcg gcagcggcat gacttcgctg ctcatgaact ccgtgtaccc     2760

gcgggagcag atcaaccagc tcacctccta catagacgca tccaacgtgt acgggagcac     2820

ggagcatgag gcccgcagca tccgcgacct ggccagccac cgcggcctgc tgcggcaggg     2880

catcgtgcag cggtccggga agccgctgct ccccttcgcc accgggccgc ccacggagtg     2940

catgcgggac gagaacgaga gccccatccc ctgcttcctg gccggggacc accgcgccaa     3000

cgagcagctg ggcctgacca gcatgcacac gctgtggttc cgcgagcaca accgcattgc     3060

cacggagctg ctcaagctga acccgcactg ggacggcgac accatctact atgagaccag     3120

gaagatcgtg ggtgcggaga tccagcacat cacctaccag cactggctcc cgaagatcct     3180

gggggaggtg ggcatgagga cgctgggaga gtaccacggc tacgaccccg gcatcaatgc     3240

tggcatcttc aacgccttcg ccaccgcggc cttcaggttt ggccacacgc ttgtcaaccc     3300

actgctttac cggctggacg agaacttcca gcccattgca caagatcacc tcccccttca     3360

caaagctttc ttctctccct tccggattgt gaatgagggc ggcatcgatc cgcttctcag     3420

ggggctgttc ggggtggcgg ggaaaatgcg tgtgccctcg cagctgctga acacggagct     3480

cacggagcgg ctgttctcca tggcacacac ggtggctctg gacctggcgg ccatcaacat     3540

ccagcggggc cgggaccacg ggatcccacc ctaccacgac tacagggtct actgcaatct     3600

atcggcggca cacacgttcg aggacctgaa aaatgagatt aaaaaccctg agatccggga     3660

gaaactgaaa aggttgtatg gctcgacact caacatcgac ctgtttccgg cgctcgtggt     3720

ggaggacctg gtgcctggca gccggctggg ccccaccctg atgtgtcttc tcagcacaca     3780

gttcaagcgc ctgcgagatg gggacaggtt gtggtatgag aaccctgggg tgttctcccc     3840

ggcccagctg actcagatca agcagacgtc gctggccagg atcctatgcg acaacgcgga     3900

caacatcacc cgggtgcaga gcgacgtgtt cagggtggcg gagttccctc acggctacgg     3960

cagctgtgac gagatcccca gggtagacct ccgggtgtgg caggactgct gtgaagactg     4020

taggaccagg gggcagttca atgccttttc ctatcatttc cgaggcagac ggtctcttga     4080

gttcagctac caggaggaca agccgaccaa gaaaacaaga ccacggaaaa tacccagtgt     4140

tgggagacag ggggaacatc tcagcaacag cacctcagcc ttcagcacac gctcagatgc     4200

atctgggaca aatgacttca gagagtttgt tctggaaatg cagaagacca tcacagacct     4260

cagaacacag ataaagaaac ttgaatcacg gctcagtacc acagagtgcg tggatgccgg     4320

gggcgaatct cacgccaaca acaccaagtg gaaaaaagat gcatgcacca tttgtgaatg     4380

caaagacggg caggtcacct gcttcgtgga agcttgcccc cctgccacct gtgctgtccc     4440

cgtgaacatc ccaggggcct gctgtccagt ctgcttacag aagagggcgg aggaaaagcc     4500

ctaggctcct gggaggctcc tcagagtttg tctgctgtgc catcgtgaga tcgggtggcc     4560

gatggcaggg agctgcggac tgcagaccag gaaacaccca gaactcgtga catttcatga     4620

caacgtccag ctggtgctgt tacagaaggc agtgcaggag gcttccaacc agagcatctg     4680

cggagaagga ggcacagcag gtgcctgaag ggaagcaggc aggagtccta gcttcacgtt     4740

agacttctca ggtttttatt taattctttt aaaatgaaaa attggtgcta ctattaaatt     4800

gcacagttga atcatttagg cgcctaaatt gattttgcct cccaacacca tttcttttta     4860

aataaagcag gatacctcta tatgtcagcc ttgccttgtt cagatgccag gagccggcag     4920

acctgtcacc cgcaggtggg gtgagtcttg gagctgccag aggggctcac cgaaatcggg     4980

gttccatcac aagctatgtt taaaaagaaa attggtgttt ggcaaacgga acagaacctt     5040

tgatgagagc gttcacaggg acactgtctg ggggtgcagt gcaagccccc ggcctcttcc     5100

ctgggaacct ctgaactcct ccttcctctg ggctctctgt aacatttcac cacacgtcag     5160

catctaatcc caagacaaac attcccgctg ctcgaagcag ctgtatagcc tgtgactctc     5220

cgtgtgtcag ctccttccac acctgattag aacattcata agccacattt agaaacaggt     5280

ttgctttcag ctgtcacttg cacacatact gcctagttgt gaaccaaatg tgaaaaaacc     5340

tccttcatcc cattgtgtat ctgatacctg ccgagggcca agggtgtgtg ttgacaacgc     5400

cgctcccagc cggccctggt tgcgtccacg tcctgaacaa gagccgcttc cggatggctc     5460

ttcccaaggg aggaggagct caagtgtcgg gaactgtcta acttcaggtt gtgtgagtgc     5520

gttaaaaaaa aaaaaaaaaa agaatcccta tacctcattt gtatttttaa aatgcgtgat     5580

gttttatgaa attgtgtcca ttttttaggt attagatatg gcagaaaaac catttccact     5640

atgcaaagtt cttttagacg tcagtgaaaa tcaactctca tacctcatgg tctctcttta     5700

attgaccaaa accttccatt tttctctaaa tacaaagcga tctgtgttct gagcaacctt     5760

tccccgaaca cacagcttca gtgcagcacg ctgacctgag tatccaccat gtgccaggca     5820

cagtgctggg cacacgaggc accaaggtcc gggccacctg cccgcagcaa ggcccagctg     5880

aggtggtgga gggagcccct gaggtcaggg gccgtttcgg ttcagggtgg caggtgtcca     5940

gcactggggt atggcgtcga ggcttccatg gggtggggga ggccagcttc cttctgacag     6000

gatgggcgca tacagtgcct ggtgtgattt gtgcacaacc cgtgttccag gtgcacatcc     6060

tcccaaggag acacccagac ccttccagca cgggccggcc aagttgctgc ggcggaggca     6120

gcatttcagc tgtgaggaag gtcattggat tcatgtgttt tatctgtaaa aatggttgtc     6180

ttaacttctt aacctcatat tggtaagtga ttgataaaaa ttggttggtg tttcatgaca     6240

tgtggacttc ttttgaaata gcaagtcaaa tgtagtgacc aaattgtgga agagatttct     6300

gtcaaatagg aaatgtgtaa gttcgtctaa aagctgatgg ttatgtaagt tgctcaggca     6360

ctcagatgac agcagattct gggttctggg agtgttctgt gcctcttaca tgccctggag     6420

gcctcatggt ctcagtgctg aggcggcaca cctgtagcac acctgcgtaa tgtgcggtct     6480

gggccagtca caaggaattg tgttgtctaa gccaaagggg gaagctgact gtgatttacc     6540

aaaaaaaatt ctgtaattca aaccaaaatg tctgcggaat caccagtttg atactctctg     6600

taatcagaac agtgggcagt gcctgggtga acgtgtctag cagccactgt gcgggatcgc     6660

tgtaacagga gtggaatgta catatttatt tacttttcta actgctccaa cagccaaatg     6720

ccttttttat gaccattgta ttcagttcat taccaaagaa atgtttgcac tttgtaatga     6780

tgcctttcag ttcaaataaa tgggtcacat tttcaaatgg a                         6821


<210>  23
<211>  1479
<212>  PRT
<213>  Homo Sapien

<400>  23

Met Ala Lys Arg Ser Arg Gly Pro Gly Arg Arg Cys Leu Leu Ala Leu 
1               5                   10                  15      


Val Leu Phe Cys Ala Trp Gly Thr Leu Ala Val Val Ala Gln Lys Pro 
            20                  25                  30          


Gly Ala Gly Cys Pro Ser Arg Cys Leu Cys Phe Arg Thr Thr Val Arg 
        35                  40                  45              


Cys Met His Leu Leu Leu Glu Ala Val Pro Ala Val Ala Pro Gln Thr 
    50                  55                  60                  


Ser Ile Leu Asp Leu Arg Phe Asn Arg Ile Arg Glu Ile Gln Pro Gly 
65                  70                  75                  80  


Ala Phe Arg Arg Leu Arg Asn Leu Asn Thr Leu Leu Leu Asn Asn Asn 
                85                  90                  95      


Gln Ile Lys Arg Ile Pro Ser Gly Ala Phe Glu Asp Leu Glu Asn Leu 
            100                 105                 110         


Lys Tyr Leu Tyr Leu Tyr Lys Asn Glu Ile Gln Ser Ile Asp Arg Gln 
        115                 120                 125             


Ala Phe Lys Gly Leu Ala Ser Leu Glu Gln Leu Tyr Leu His Phe Asn 
    130                 135                 140                 


Gln Ile Glu Thr Leu Asp Pro Asp Ser Phe Gln His Leu Pro Lys Leu 
145                 150                 155                 160 


Glu Arg Leu Phe Leu His Asn Asn Arg Ile Thr His Leu Val Pro Gly 
                165                 170                 175     


Thr Phe Asn His Leu Glu Ser Met Lys Arg Leu Arg Leu Asp Ser Asn 
            180                 185                 190         


Thr Leu His Cys Asp Cys Glu Ile Leu Trp Leu Ala Asp Leu Leu Lys 
        195                 200                 205             


Thr Tyr Ala Glu Ser Gly Asn Ala Gln Ala Ala Ala Ile Cys Glu Tyr 
    210                 215                 220                 


Pro Arg Arg Ile Gln Gly Arg Ser Val Ala Thr Ile Thr Pro Glu Glu 
225                 230                 235                 240 


Leu Asn Cys Glu Arg Pro Arg Ile Thr Ser Glu Pro Gln Asp Ala Asp 
                245                 250                 255     


Val Thr Ser Gly Asn Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly Asn 
            260                 265                 270         


Pro Lys Pro Glu Ile Ile Trp Leu Arg Asn Asn Asn Glu Leu Ser Met 
        275                 280                 285             


Lys Thr Asp Ser Arg Leu Asn Leu Leu Asp Asp Gly Thr Leu Met Ile 
    290                 295                 300                 


Gln Asn Thr Gln Glu Thr Asp Gln Gly Ile Tyr Gln Cys Met Ala Lys 
305                 310                 315                 320 


Asn Val Ala Gly Glu Val Lys Thr Gln Glu Val Thr Leu Arg Tyr Phe 
                325                 330                 335     


Gly Ser Pro Ala Arg Pro Thr Phe Val Ile Gln Pro Gln Asn Thr Glu 
            340                 345                 350         


Val Leu Val Gly Glu Ser Val Thr Leu Glu Cys Ser Ala Thr Gly His 
        355                 360                 365             


Pro Pro Pro Arg Ile Ser Trp Thr Arg Gly Asp Arg Thr Pro Leu Pro 
    370                 375                 380                 


Val Asp Pro Arg Val Asn Ile Thr Pro Ser Gly Gly Leu Tyr Ile Gln 
385                 390                 395                 400 


Asn Val Val Gln Gly Asp Ser Gly Glu Tyr Ala Cys Ser Ala Thr Asn 
                405                 410                 415     


Asn Ile Asp Ser Val His Ala Thr Ala Phe Ile Ile Val Gln Ala Leu 
            420                 425                 430         


Pro Gln Phe Thr Val Thr Pro Gln Asp Arg Val Val Ile Glu Gly Gln 
        435                 440                 445             


Thr Val Asp Phe Gln Cys Glu Ala Lys Gly Asn Pro Pro Pro Val Ile 
    450                 455                 460                 


Ala Trp Thr Lys Gly Gly Ser Gln Leu Ser Val Asp Arg Arg His Leu 
465                 470                 475                 480 


Val Leu Ser Ser Gly Thr Leu Arg Ile Ser Gly Val Ala Leu His Asp 
                485                 490                 495     


Gln Gly Gln Tyr Glu Cys Gln Ala Val Asn Ile Ile Gly Ser Gln Lys 
            500                 505                 510         


Val Val Ala His Leu Thr Val Gln Pro Arg Val Thr Pro Val Phe Ala 
        515                 520                 525             


Ser Ile Pro Ser Asp Thr Thr Val Glu Val Gly Ala Asn Val Gln Leu 
    530                 535                 540                 


Pro Cys Ser Ser Gln Gly Glu Pro Glu Pro Ala Ile Thr Trp Asn Lys 
545                 550                 555                 560 


Asp Gly Val Gln Val Thr Glu Ser Gly Lys Phe His Ile Ser Pro Glu 
                565                 570                 575     


Gly Phe Leu Thr Ile Asn Asp Val Gly Pro Ala Asp Ala Gly Arg Tyr 
            580                 585                 590         


Glu Cys Val Ala Arg Asn Thr Ile Gly Ser Ala Ser Val Ser Met Val 
        595                 600                 605             


Leu Ser Val Asn Val Pro Asp Val Ser Arg Asn Gly Asp Pro Phe Val 
    610                 615                 620                 


Ala Thr Ser Ile Val Glu Ala Ile Ala Thr Val Asp Arg Ala Ile Asn 
625                 630                 635                 640 


Ser Thr Arg Thr His Leu Phe Asp Ser Arg Pro Arg Ser Pro Asn Asp 
                645                 650                 655     


Leu Leu Ala Leu Phe Arg Tyr Pro Arg Asp Pro Tyr Thr Val Glu Gln 
            660                 665                 670         


Ala Arg Ala Gly Glu Ile Phe Glu Arg Thr Leu Gln Leu Ile Gln Glu 
        675                 680                 685             


His Val Gln His Gly Leu Met Val Asp Leu Asn Gly Thr Ser Tyr His 
    690                 695                 700                 


Tyr Asn Asp Leu Val Ser Pro Gln Tyr Leu Asn Leu Ile Ala Asn Leu 
705                 710                 715                 720 


Ser Gly Cys Thr Ala His Arg Arg Val Asn Asn Cys Ser Asp Met Cys 
                725                 730                 735     


Phe His Gln Lys Tyr Arg Thr His Asp Gly Thr Cys Asn Asn Leu Gln 
            740                 745                 750         


His Pro Met Trp Gly Ala Ser Leu Thr Ala Phe Glu Arg Leu Leu Lys 
        755                 760                 765             


Ser Val Tyr Glu Asn Gly Phe Asn Thr Pro Arg Gly Ile Asn Pro His 
    770                 775                 780                 


Arg Leu Tyr Asn Gly His Ala Leu Pro Met Pro Arg Leu Val Ser Thr 
785                 790                 795                 800 


Thr Leu Ile Gly Thr Glu Thr Val Thr Pro Asp Glu Gln Phe Thr His 
                805                 810                 815     


Met Leu Met Gln Trp Gly Gln Phe Leu Asp His Asp Leu Asp Ser Thr 
            820                 825                 830         


Val Val Ala Leu Ser Gln Ala Arg Phe Ser Asp Gly Gln His Cys Ser 
        835                 840                 845             


Asn Val Cys Ser Asn Asp Pro Pro Cys Phe Ser Val Met Ile Pro Pro 
    850                 855                 860                 


Asn Asp Ser Arg Ala Arg Ser Gly Ala Arg Cys Met Phe Phe Val Arg 
865                 870                 875                 880 


Ser Ser Pro Val Cys Gly Ser Gly Met Thr Ser Leu Leu Met Asn Ser 
                885                 890                 895     


Val Tyr Pro Arg Glu Gln Ile Asn Gln Leu Thr Ser Tyr Ile Asp Ala 
            900                 905                 910         


Ser Asn Val Tyr Gly Ser Thr Glu His Glu Ala Arg Ser Ile Arg Asp 
        915                 920                 925             


Leu Ala Ser His Arg Gly Leu Leu Arg Gln Gly Ile Val Gln Arg Ser 
    930                 935                 940                 


Gly Lys Pro Leu Leu Pro Phe Ala Thr Gly Pro Pro Thr Glu Cys Met 
945                 950                 955                 960 


Arg Asp Glu Asn Glu Ser Pro Ile Pro Cys Phe Leu Ala Gly Asp His 
                965                 970                 975     


Arg Ala Asn Glu Gln Leu Gly Leu Thr Ser Met His Thr Leu Trp Phe 
            980                 985                 990         


Arg Glu His Asn Arg Ile Ala Thr  Glu Leu Leu Lys Leu  Asn Pro His 
        995                 1000                 1005             


Trp Asp  Gly Asp Thr Ile Tyr  Tyr Glu Thr Arg Lys  Ile Val Gly 
    1010                 1015                 1020             


Ala Glu  Ile Gln His Ile Thr  Tyr Gln His Trp Leu  Pro Lys Ile 
    1025                 1030                 1035             


Leu Gly  Glu Val Gly Met Arg  Thr Leu Gly Glu Tyr  His Gly Tyr 
    1040                 1045                 1050             


Asp Pro  Gly Ile Asn Ala Gly  Ile Phe Asn Ala Phe  Ala Thr Ala 
    1055                 1060                 1065             


Ala Phe  Arg Phe Gly His Thr  Leu Val Asn Pro Leu  Leu Tyr Arg 
    1070                 1075                 1080             


Leu Asp  Glu Asn Phe Gln Pro  Ile Ala Gln Asp His  Leu Pro Leu 
    1085                 1090                 1095             


His Lys  Ala Phe Phe Ser Pro  Phe Arg Ile Val Asn  Glu Gly Gly 
    1100                 1105                 1110             


Ile Asp  Pro Leu Leu Arg Gly  Leu Phe Gly Val Ala  Gly Lys Met 
    1115                 1120                 1125             


Arg Val  Pro Ser Gln Leu Leu  Asn Thr Glu Leu Thr  Glu Arg Leu 
    1130                 1135                 1140             


Phe Ser  Met Ala His Thr Val  Ala Leu Asp Leu Ala  Ala Ile Asn 
    1145                 1150                 1155             


Ile Gln  Arg Gly Arg Asp His  Gly Ile Pro Pro Tyr  His Asp Tyr 
    1160                 1165                 1170             


Arg Val  Tyr Cys Asn Leu Ser  Ala Ala His Thr Phe  Glu Asp Leu 
    1175                 1180                 1185             


Lys Asn  Glu Ile Lys Asn Pro  Glu Ile Arg Glu Lys  Leu Lys Arg 
    1190                 1195                 1200             


Leu Tyr  Gly Ser Thr Leu Asn  Ile Asp Leu Phe Pro  Ala Leu Val 
    1205                 1210                 1215             


Val Glu  Asp Leu Val Pro Gly  Ser Arg Leu Gly Pro  Thr Leu Met 
    1220                 1225                 1230             


Cys Leu  Leu Ser Thr Gln Phe  Lys Arg Leu Arg Asp  Gly Asp Arg 
    1235                 1240                 1245             


Leu Trp  Tyr Glu Asn Pro Gly  Val Phe Ser Pro Ala  Gln Leu Thr 
    1250                 1255                 1260             


Gln Ile  Lys Gln Thr Ser Leu  Ala Arg Ile Leu Cys  Asp Asn Ala 
    1265                 1270                 1275             


Asp Asn  Ile Thr Arg Val Gln  Ser Asp Val Phe Arg  Val Ala Glu 
    1280                 1285                 1290             


Phe Pro  His Gly Tyr Gly Ser  Cys Asp Glu Ile Pro  Arg Val Asp 
    1295                 1300                 1305             


Leu Arg  Val Trp Gln Asp Cys  Cys Glu Asp Cys Arg  Thr Arg Gly 
    1310                 1315                 1320             


Gln Phe  Asn Ala Phe Ser Tyr  His Phe Arg Gly Arg  Arg Ser Leu 
    1325                 1330                 1335             


Glu Phe  Ser Tyr Gln Glu Asp  Lys Pro Thr Lys Lys  Thr Arg Pro 
    1340                 1345                 1350             


Arg Lys  Ile Pro Ser Val Gly  Arg Gln Gly Glu His  Leu Ser Asn 
    1355                 1360                 1365             


Ser Thr  Ser Ala Phe Ser Thr  Arg Ser Asp Ala Ser  Gly Thr Asn 
    1370                 1375                 1380             


Asp Phe  Arg Glu Phe Val Leu  Glu Met Gln Lys Thr  Ile Thr Asp 
    1385                 1390                 1395             


Leu Arg  Thr Gln Ile Lys Lys  Leu Glu Ser Arg Leu  Ser Thr Thr 
    1400                 1405                 1410             


Glu Cys  Val Asp Ala Gly Gly  Glu Ser His Ala Asn  Asn Thr Lys 
    1415                 1420                 1425             


Trp Lys  Lys Asp Ala Cys Thr  Ile Cys Glu Cys Lys  Asp Gly Gln 
    1430                 1435                 1440             


Val Thr  Cys Phe Val Glu Ala  Cys Pro Pro Ala Thr  Cys Ala Val 
    1445                 1450                 1455             


Pro Val  Asn Ile Pro Gly Ala  Cys Cys Pro Val Cys  Leu Gln Lys 
    1460                 1465                 1470             


Arg Ala  Glu Glu Lys Pro 
    1475                 


<210>  24
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  24
aaatgggctt gaagctgctt acgaatttgc cgacagagat gaagtccggt ttttcaaagg       60

gaataagtac tgggctgttc agggacagaa tgtgctacac                            100


<210>  25
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  25
tgggcttaag ttttcaagga ccaaaaggtg acaagggtga ccaaggggtc agtgggcctc       60

caggagtacc aggacaagct caagttcaag aaaaaggaga                            100


<210>  26
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  26
tgtgcttgtg ggctgcaagt gggtctccaa taagtggttc catgaacgag gacaggagtt       60

cttgagacct tgtggatcaa cagaagttga ctgacatcct                            100


<210>  27
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  27
aaacatcctt gcaaatgggt gtgacgcggt tccagatgtg gatttggcaa aacctcattt       60

aagtaaaagg ttagcagagc aaagtgcggt gctttagctg                            100


<210>  28
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  28
ttggcacaac aggaagctgt tgaaggagga tgttcccatc ttggtcagtc ctatgcggat       60

agagatgtct ggaagccaga accatgccaa atatgtgtct                            100


<210>  29
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  29
tgggcttaag ttttcaagga ccaaaaggtg acaagggtga ccaaggggtc agtgggcctc       60

caggagtacc aggacaagct caagttcaag aaaaaggaga                            100


<210>  30
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  30
gtaaaggtca tcccaccatc accaaagcct ccgtttttaa caacctccaa cacgatccat       60

ttagaggcca aatgtcattc tgcaggtgcc ttcccgatgg                            100


<210>  31
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  31
ggttcatgct accctgaagt cactcagtag tcagattgaa accatgcgca gccccgatgg       60

ctcgaaaaag cacccagccc gcacgtgtga tgacctaaag                            100


<210>  32
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  32
ctgtggaagg actttgtgaa ggaattggtg ctggattagt ggatgttgct atctgggttg       60

gcacttgttc agattaccca aaaggagatg cttctactgg                            100


<210>  33
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  33
aggccctgcc cttataggaa cagaagagga aagagagaca cagctgcaga ggccacctgg       60

attgtgccta atgtgtttga gcatcgctta ggagaagtct                            100


<210>  34
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  34
gagaagatgt ttgaaaaaac tgactctgct aatgagcctg gactcagagc tcaagtctga       60

actctacctc cagacagaat gaagttcatc tcgacatctc                            100


<210>  35
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  35
aaatgggctt gaagctgctt acgaatttgc cgacagagat gaagtccggt ttttcaaagg       60

gaataagtac tgggctgttc agggacagaa tgtgctacac                            100


<210>  36
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  36
tgtgcttgtg ggctgcaagt gggtctccaa taagtggttc catgaacgag gacaggagtt       60

cttgagacct tgtggatcaa cagaagttga ctgacatcct                            100


<210>  37
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  37
ctccaggaac cagcgaagac cgctataagt ctggcttgac aactctggtg gcaacaagtg       60

tcaacagtgt aacaggcatt cgcatcgagg atctgccaac                            100


<210>  38
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  38
aaacattgca cttaataacg tgggagaaga ctttcaggga ggtggttgca aatttctaag       60

gtacaattgc tctattgagt caccacgaaa aggctggagc                            100


<210>  39
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  39
agagacggtc acttcacact ctttgctccc accaatgagg cttttgagaa acttccacga       60

ggtgtcctag aaaggatcat gggagacaaa gtggcttccg                            100


<210>  40
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  40
tggaggggca ggcttgcgag ctgcatttgg cctttctgag gcagggttta atacagcatg       60

tgttaccaag ctgtttccta ccaggtcaca cactgttgca                            100


<210>  41
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  41
tgtgttcaat agatttagga gcagaaatgc aaggggctgc atgacctacc aggacagaac       60

tttccccaat tacagggtga ctcacagccg cattggtgac                            100


<210>  42
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  42
cgctgccttc catctgctcc cacttcaatc ctctgtctct cgaggaacta ggctccaaca       60

cggggatcca ggttttcaat cagattgtga agtcgaggcc                            100


<210>  43
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  43
atggtggaca accgtggctt catggtgact cggtcctata ccgtgggtgt catgatgatg       60

caccggacag gcctctacaa ctactacgac gacgagaagg                            100


<210>  44
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  44
aaacatcctt gcaaatgggt gtgacgcggt tccagatgtg gatttggcaa aacctcattt       60

aagtaaaagg ttagcagagc aaagtgcggt gctttagctg                            100


<210>  45
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  45
cagaaatctt gaaggcaggc gcaaacgggc ataaattgga gggaccactg ggtgagagag       60

gaataaggcg gcccagagcg aggaaaggat tttaccaaag                            100


<210>  46
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  46
tcctcctgtt cgacagtcag ccgcatcttc ttttgcgtcg ccagccgagc cacatcgctc       60

agacaccatg gggaaggtga aggtcggagt caacggattt                            100


<210>  47
<211>  100
<212>  DNA
<213>  Homo Sapien

<400>  47
gcggcggaaa atagcctttg ccatcactgc cattaagggt gtgggccgaa gatatgctca       60

tgtggtgttg aggaaagcag acattgacct caccaagagg                            100


<210>  48
<211>  22
<212>  DNA
<213>  Homo Sapien

<400>  48
cctgttcgac agtcagccgc at                                                22


<210>  49
<211>  22
<212>  DNA
<213>  Homo Sapien

<400>  49
gactccgacc ttcaccttcc cc                                                22


<210>  50
<211>  22
<212>  DNA
<213>  Homo Sapien

<400>  50
gcggcggaaa atagcctttg cc                                                22


<210>  51
<211>  24
<212>  DNA
<213>  Homo Sapien

<400>  51
cctcttggtg aggtcaatgt ctgc                                              24


<210>  52
<211>  24
<212>  DNA
<213>  Homo Sapien

<400>  52
caaatgggct tgaagctgct tacg                                              24


<210>  53
<211>  25
<212>  DNA
<213>  Homo Sapien

<400>  53
gtgtagcaca ttctgtccct gaaca                                             25


<210>  54
<211>  25
<212>  DNA
<213>  Homo Sapien

<400>  54
aaggaccaaa aggtgacaag ggtga                                             25


<210>  55
<211>  25
<212>  DNA
<213>  Homo Sapien

<400>  55
gaacttgagc ttgtcctggt actcc                                             25


<210>  56
<211>  23
<212>  DNA
<213>  Homo Sapien

<400>  56
gtcatcccac catcaccaaa gcc                                               23


<210>  57
<211>  23
<212>  DNA
<213>  Homo Sapien

<400>  57
atcgggaagg cacctgcaga atg                                               23


<210>  58
<211>  22
<212>  DNA
<213>  Homo Sapien

<400>  58
ttgcaaatgg gtgtgacgcg gt                                                22


<210>  59
<211>  22
<212>  DNA
<213>  Homo Sapien

<400>  59
aagcaccgca ctttgctctg ct                                                22


<210>  60
<211>  25
<212>  DNA
<213>  Homo Sapien

<400>  60
acgaacactc aatccagttt gctga                                             25


<210>  61
<211>  23
<212>  DNA
<213>  Homo Sapien

<400>  61
tggaatttat gcccgtttgc gcc                                               23


<210>  62
<211>  25
<212>  DNA
<213>  Homo Sapien

<400>  62
tggcacaaca ggaagctgtt gaagg                                             25


<210>  63
<211>  25
<212>  DNA
<213>  Homo Sapien

<400>  63
acacatattt ggcatggttc tggct                                             25


<210>  64
<211>  25
<212>  DNA
<213>  Homo Sapien

<400>  64
tcatgctacc ctgaagtcac tcagt                                             25


<210>  65
<211>  20
<212>  DNA
<213>  Homo Sapien

<400>  65
aggtcatcac acgtgcgggc                                                   20


<210>  66
<211>  21
<212>  DNA
<213>  Homo Sapien

<400>  66
caggaaccag cgaagaccgc t                                                 21


<210>  67
<211>  23
<212>  DNA
<213>  Homo Sapien

<400>  67
tggcagatcc tcgatgcgaa tgc                                               23


<210>  68
<211>  25
<212>  DNA
<213>  Homo Sapien

<400>  68
cggtcacttc acactctttg ctccc                                             25


<210>  69
<211>  24
<212>  DNA
<213>  Homo Sapien

<400>  69
cggaagccac tttgtctccc atga                                              24


<210>  70
<211>  23
<212>  DNA
<213>  Homo Sapien

<400>  70
accatgaact ggcatctccc cct                                               23


<210>  71
<211>  24
<212>  DNA
<213>  Homo Sapien

<400>  71
tggagcctag ttcctcgaga gaca                                              24


<210>  72
<211>  22
<212>  DNA
<213>  Homo Sapien

<400>  72
ccgtggcttc atggtgactc gg                                                22


<210>  73
<211>  24
<212>  DNA
<213>  Homo Sapien

<400>  73
agtagttgta gaggcctgtc cggt                                              24


<210>  74
<211>  22
<212>  DNA
<213>  Homo Sapien

<400>  74
ctccaagccc atccaggggc aa                                                22


<210>  75
<211>  23
<212>  DNA
<213>  Homo Sapien

<400>  75
cagagtgacc ttcccagtgc caa                                               23


<210>  76
<211>  24
<212>  DNA
<213>  Homo Sapien

<400>  76
tggctctttg ccgaaatgct agag                                              24


<210>  77
<211>  24
<212>  DNA
<213>  Homo Sapien

<400>  77
gggggctgag catttggaat gttt                                              24


<210>  78
<211>  20
<212>  DNA
<213>  Homo Sapien

<400>  78
aggagctgcc aaagccctga                                                   20


<210>  79
<211>  22
<212>  DNA
<213>  Homo Sapien

<400>  79
acctgctcca tccacaacac cg                                                22


<210>  80
<211>  20
<212>  DNA
<213>  Homo Sapien

<400>  80
ttgttcagtg gctcacttcg                                                   20


<210>  81
<211>  20
<212>  DNA
<213>  Homo Sapien

<400>  81
ttcaatggga agaggtcctg                                                   20


<210>  82
<211>  20
<212>  DNA
<213>  Homo Sapien

<400>  82
atttctgagg agcctgcaac                                                   20


<210>  83
<211>  20
<212>  DNA
<213>  Homo Sapien

<400>  83
cacatacatt cccctgcctt                                                   20


<210>  84
<211>  20
<212>  DNA
<213>  Homo Sapien

<400>  84
gagcctgtca agaggcaaag                                                   20


<210>  85
<211>  20
<212>  DNA
<213>  Homo Sapien

<400>  85
ctggggatct tcgaatgcta                                                   20


