                         SEQUENCE LISTING

<110>  Adamed Sp. z o.o.
       Pieczykolan, Jerzy   Szczepan
       Pawlak, Sebastian   Dominik
       erek , Bartomiej    Maciej
       Rzga, Piotr   Kamil
 
<120>  Anticancer fusion protein

<130>  KP4

<150>  PL393578
<151>  2010-01-05

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein sequence

<400>  1

Arg Lys Arg Lys Lys Ser Arg Gly Gly Gly Gly Gly Arg Val Ala Ala 
1               5                   10                  15      


His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn 
            20                  25                  30          


Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser 
        35                  40                  45              


Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly 
    50                  55                  60                  


Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr 
65                  70                  75                  80  


Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys 
                85                  90                  95      


Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile 
            100                 105                 110         


Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu 
        115                 120                 125             


Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu 
    130                 135                 140                 


Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met 
145                 150                 155                 160 


Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
                165                 170             


<210>  2
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein sequence

<400>  2

Arg Lys Arg Lys Lys Ser Arg Gly Gly Gly Gly Gly Thr Ser Glu Glu 
1               5                   10                  15      


Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu Val 
            20                  25                  30          


Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
        35                  40                  45              


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
    50                  55                  60                  


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
65                  70                  75                  80  


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
                85                  90                  95      


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
            100                 105                 110         


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
        115                 120                 125             


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
    130                 135                 140                 


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
145                 150                 155                 160 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
                165                 170                 175     


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
            180                 185                 190         


Phe Gly Ala Phe Leu Val Gly 
        195                 


<210>  3
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein sequence

<400>  3

Arg Lys Arg Lys Lys Ser Arg Gly Gly Gly Gly Gly Arg Val Ala Ala 
1               5                   10                  15      


His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn 
            20                  25                  30          


Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser 
        35                  40                  45              


Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly 
    50                  55                  60                  


Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr 
65                  70                  75                  80  


Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys 
                85                  90                  95      


Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile 
            100                 105                 110         


Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu 
        115                 120                 125             


Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu 
    130                 135                 140                 


Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met 
145                 150                 155                 160 


Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly 
                165                 170                 175     


Pro Leu Gly Leu Ala Gly Arg Val Val Arg Thr Met Pro Phe Leu Phe 
            180                 185                 190         


Cys Asn Val Asn Asp Val Cys Asn Phe Ala Ser Arg Asn Asp Tyr Ser 
        195                 200                 205             


Tyr Trp Leu Cys Asn Tyr Tyr Ser Asn Ser Tyr Ser Phe Trp Leu Ala 
    210                 215                 220                 


Ser Leu Asn Pro Glu Arg 
225                 230 


<210>  4
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein sequence

<400>  4

Arg Lys Arg Lys Lys Ser Arg Pro Leu Gly Leu Ala Gly Glu Arg Lys 
1               5                   10                  15      


Arg Lys Lys Ser Arg Gly Gly Gly Gly Gly Arg Val Ala Ala His Ile 
            20                  25                  30          


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
        35                  40                  45              


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
    50                  55                  60                  


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
65                  70                  75                  80  


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
                85                  90                  95      


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
            100                 105                 110         


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
        115                 120                 125             


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
    130                 135                 140                 


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
145                 150                 155                 160 


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
                165                 170                 175     


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
            180                 185         


<210>  5
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein sequence

<400>  5

Arg Lys Arg Lys Lys Ser Arg Val Val Arg Pro Leu Gly Leu Ala Gly 
1               5                   10                  15      


Glu Arg Lys Arg Lys Lys Ser Arg Gly Gly Arg Val Ala Ala His Ile 
            20                  25                  30          


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
        35                  40                  45              


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
    50                  55                  60                  


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
65                  70                  75                  80  


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
                85                  90                  95      


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
            100                 105                 110         


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
        115                 120                 125             


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
    130                 135                 140                 


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
145                 150                 155                 160 


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
                165                 170                 175     


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
            180                 185         


<210>  6
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein sequence

<400>  6

Arg Lys Arg Lys Lys Ser Arg Val Val Arg Pro Leu Gly Ile Ala Gly 
1               5                   10                  15      


Glu Arg Lys Arg Lys Lys Ser Arg Gly Gly Gly Cys Ala Ala Ala Cys 
            20                  25                  30          


Ala Ala Cys Thr Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln 
        35                  40                  45              


Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala 
    50                  55                  60                  


Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro 
65                  70                  75                  80  


Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu 
                85                  90                  95      


Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn 
            100                 105                 110         


Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln 
        115                 120                 125             


Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp 
    130                 135                 140                 


Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro 
145                 150                 155                 160 


Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala 
                165                 170                 175     


Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys 
            180                 185                 190         


Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp 
        195                 200                 205             


Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
    210                 215                 220         


<210>  7
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein sequence

<400>  7

Cys Asn Gly Arg Cys Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
1               5                   10                  15      


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
            20                  25                  30          


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
        35                  40                  45              


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
    50                  55                  60                  


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
65                  70                  75                  80  


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
                85                  90                  95      


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
            100                 105                 110         


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
        115                 120                 125             


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
    130                 135                 140                 


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
145                 150                 155                 160 


Phe Phe Gly Ala Phe Leu Val Gly 
                165             


<210>  8
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein sequence

<400>  8

Cys Asp Cys Arg Gly Asp Cys Phe Cys Gly Gly Gly Gly Ser Thr Ser 
1               5                   10                  15      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            20                  25                  30          


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        35                  40                  45              


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    50                  55                  60                  


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
65                  70                  75                  80  


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                85                  90                  95      


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            100                 105                 110         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        115                 120                 125             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    130                 135                 140                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
145                 150                 155                 160 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                165                 170                 175     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            180                 185                 190         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        195                 200     


<210>  9
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein sequence

<400>  9

Tyr Gly Arg Pro Arg Gln Ser Gly Lys Lys Arg Lys Arg Lys Arg Leu 
1               5                   10                  15      


Lys Pro Thr Arg Val Val Arg Pro Leu Gly Leu Ala Gly Pro Gln Arg 
            20                  25                  30          


Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser 
        35                  40                  45              


Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser 
    50                  55                  60                  


Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu 
65                  70                  75                  80  


Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr 
                85                  90                  95      


Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys 
            100                 105                 110         


Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro 
        115                 120                 125             


Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys 
    130                 135                 140                 


Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu 
145                 150                 155                 160 


Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu 
                165                 170                 175     


Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
            180                 185                 190         


<210>  10
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein sequence

<400>  10

Tyr Gly Arg Pro Arg Gln Ser Gly Lys Lys Arg Lys Arg Lys Arg Leu 
1               5                   10                  15      


Lys Pro Thr Arg Val Val Arg Pro Leu Gly Leu Ala Gly Thr Ser Glu 
            20                  25                  30          


Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu 
        35                  40                  45              


Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
    50                  55                  60                  


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
65                  70                  75                  80  


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
                85                  90                  95      


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
            100                 105                 110         


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
        115                 120                 125             


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
    130                 135                 140                 


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
145                 150                 155                 160 


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
                165                 170                 175     


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
            180                 185                 190         


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
        195                 200                 205             


Phe Phe Gly Ala Phe Leu Val Gly 
    210                 215     


<210>  11
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein sequence

<400>  11

Tyr Gly Arg Pro Arg Gln Ser Gly Lys Lys Arg Lys Arg Lys Arg Leu 
1               5                   10                  15      


Lys Pro Thr Arg Val Val Arg Pro Leu Gly Leu Ala Gly Gly Gly Cys 
            20                  25                  30          


Ala Ala Ala Cys Ala Ala Cys Thr Ser Glu Glu Thr Ile Ser Thr Val 
        35                  40                  45              


Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly Pro 
    50                  55                  60                  


Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 
65                  70                  75                  80  


Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 
                85                  90                  95      


Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 
            100                 105                 110         


His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 
        115                 120                 125             


Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 
    130                 135                 140                 


Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 
145                 150                 155                 160 


Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 
                165                 170                 175     


Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 
            180                 185                 190         


Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 
        195                 200                 205             


His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 
    210                 215                 220                 


Val Gly 
225     


<210>  12
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein sequence

<400>  12

Thr Met Pro Phe Leu Phe Cys Asn Val Asn Asp Val Cys Asn Phe Ala 
1               5                   10                  15      


Ser Arg Asn Asp Tyr Ser Tyr Trp Leu Cys Asn Tyr Tyr Ser Asn Ser 
            20                  25                  30          


Tyr Ser Phe Trp Leu Ala Ser Leu Asn Pro Glu Arg Val Val Arg Pro 
        35                  40                  45              


Leu Gly Leu Ala Gly Gly Gly Gly Arg Val Ala Ala His Ile Thr Gly 
    50                  55                  60                  


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
65                  70                  75                  80  


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
                85                  90                  95      


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
            100                 105                 110         


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
        115                 120                 125             


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
    130                 135                 140                 


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
145                 150                 155                 160 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
                165                 170                 175     


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
            180                 185                 190         


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
        195                 200                 205             


Ser Phe Phe Gly Ala Phe Leu Val Gly 
    210                 215         


<210>  13
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein sequence

<400>  13

Cys Asn Tyr Tyr Ser Asn Ser Tyr Ser Phe Trp Leu Ala Ser Leu Asn 
1               5                   10                  15      


Pro Glu Arg Val Val Arg Pro Leu Gly Leu Ala Gly Gly Gly Gly Arg 
            20                  25                  30          


Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser 
        35                  40                  45              


Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser 
    50                  55                  60                  


Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu 
65                  70                  75                  80  


Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr 
                85                  90                  95      


Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys 
            100                 105                 110         


Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro 
        115                 120                 125             


Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys 
    130                 135                 140                 


Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu 
145                 150                 155                 160 


Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu 
                165                 170                 175     


Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
            180                 185                 190         


Gly Gly Gly Thr Met Pro Phe Leu Phe Cys Asn Val Asn Asp Val Cys 
        195                 200                 205             


Asn Phe Ala Ser Arg Asn Asp Tyr Ser Tyr Trp Leu 
    210                 215                 220 


<210>  14
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein sequence

<400>  14

Leu Gly Leu Arg Ser Leu Arg Glu Arg Val Val Arg Pro Leu Gly Leu 
1               5                   10                  15      


Ala Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
            20                  25                  30          


Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
        35                  40                  45              


Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
    50                  55                  60                  


Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
65                  70                  75                  80  


Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
                85                  90                  95      


Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
            100                 105                 110         


Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
        115                 120                 125             


Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
    130                 135                 140                 


Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
145                 150                 155                 160 


Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
                165                 170                 175     


Ala Phe Leu Val Gly 
            180     


<210>  15
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein sequence

<400>  15

Leu Gly Leu Arg Ser Leu Arg Glu Arg Val Val Arg Pro Leu Gly Leu 
1               5                   10                  15      


Ala Gly Pro Gly Gly Gly Cys Ala Ala Ala Cys Ala Ala Cys Thr Ser 
            20                  25                  30          


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
        35                  40                  45              


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
    50                  55                  60                  


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
65                  70                  75                  80  


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
                85                  90                  95      


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
            100                 105                 110         


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
        115                 120                 125             


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
    130                 135                 140                 


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
145                 150                 155                 160 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
                165                 170                 175     


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
            180                 185                 190         


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
        195                 200                 205             


Ser Phe Phe Gly Ala Phe Leu Val Gly 
    210                 215         


<210>  16
<211>  281
<212>  PRT
<213>  Homo sapiens

<300>
<308>  GenBank/P50591
<309>  1996-10-01
<313>  (1)..(281)

<400>  16

Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210>  17
<211>  7
<212>  PRT
<213>  Homo sapiens

<300>
<308>  GenBank/AAI72307.1
<309>  2009-03-16
<313>  (333)..(339)

<400>  17

Arg Lys Arg Lys Lys Ser Arg 
1               5           


<210>  18
<211>  25
<212>  PRT
<213>  Homo sapiens

<300>
<308>  GenBank/AAF72632.1
<309>  2000-05-30
<313>  (74)..(98)

<400>  18

Thr Met Pro Phe Leu Phe Cys Asn Val Asn Asp Val Cys Asn Phe Ala 
1               5                   10                  15      


Ser Arg Asn Asp Tyr Ser Tyr Trp Leu 
            20                  25  


<210>  19
<211>  18
<212>  PRT
<213>  Homo sapiens

<300>
<308>  GenBank/AAF72632.1
<309>  2000-05-30
<313>  (197)..(214)

<400>  19

Cys Asn Tyr Tyr Ser Asn Ser Tyr Ser Phe Trp Leu Ala Ser Leu Asn 
1               5                   10                  15      


Pro Glu 
        


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<300>
<301>  Arap W., Pasqualini R., Ruoslahti E.
<302>  Cancer treatment by targeted drug delivery to tumor vasculature
<303>  Science (Washington DC)
<304>  279
<305>  5349
<306>  377-380
<307>  1998-01-16
<313>  (1)..(5)

<400>  20

Cys Asn Gly Arg Cys 
1               5   


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<300>
<308>  PDB/1FUL_A
<309>  2009-07-10
<313>  (2)..(10)

<400>  21

Cys Asp Cys Arg Gly Asp Cys Phe Cys 
1               5                   


<210>  22
<211>  19
<212>  PRT
<213>  Homo sapiens

<300>
<301>  Khachigian LM, Owensby DA, Chesterman CN.
<302>  A tyrosinated peptide representing the alternatively spliced exon
        of the platelet-derived growth factor A-chain binds specifically
        to cultured cells and interferes with binding of several growth 
       factors.
<303>  Journal of Biological Chemistry
<304>  25
<305>  267
<306>  1660-1666
<307>  1992-01-25

<300>
<301>  Khachigian LM, Field SL, Crouch R, Chesterman CN
<302>  Platelet-derived growth factor A-chain synthetic peptide inhibits
        human glioma xenograft proliferation in nude mice.
<303>  Anticancer Res
<304>  15
<305>  2
<306>  337-41
<307>  1995-04-05

<400>  22

Tyr Gly Arg Pro Arg Gln Ser Gly Lys Lys Arg Lys Arg Lys Arg Leu 
1               5                   10                  15      


Lys Pro Thr 
            


<210>  23
<211>  8
<212>  PRT
<213>  Homo sapiens

<300>
<308>  GenBank/AAI67147.1
<309>  2008-05-05
<313>  (453)..(460)

<400>  23

Leu Gly Leu Arg Ser Leu Arg Glu 
1               5               


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cutting sequence

<400>  24

Pro Leu Gly Leu Ala Gly 
1               5       


<210>  25
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cutting sequence

<400>  25

Arg Val Val Arg 
1               


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence of steric linker

<400>  26

Gly Gly Gly Cys Ala Ala Ala Cys Ala Ala Cys 
1               5                   10      


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence of steric linker

<400>  27

Gly Gly Cys Ala Ala Ala Cys Ala Ala Cys 
1               5                   10  


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence of steric linker

<400>  28

Gly Gly Gly Gly Gly 
1               5   


<210>  29
<211>  4
<212>  PRT
<213>  Mus musculus

<300>
<308>  GenBank/CAA94521.1
<309>  1996-06-13
<313>  (122)..(124)

<400>  29

Gly Gly Gly Gly 
1               


<210>  30
<211>  5
<212>  PRT
<213>  Mus musculus

<300>
<308>  GenBank/CAA94521.1
<309>  1996-06-13
<313>  (122)..(126)

<400>  30

Gly Gly Gly Gly Ser 
1               5   


<210>  31
<211>  519
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  31
cgtaaacgca aaaaaagtcg tggtggtggt ggtggccgcg ttgcggcaca tattacgggt       60

acccgtggcc gcagcaacac gctgagctct ccgaattcga aaaatgaaaa agcactgggc      120

cgcaaaatta actcgtggga aagcagtcgt tctggtcaca gctttctgtc gaatctgcac      180

ctgcgcaatg gtgaactggt gattcatgaa aaaggctttt actatatcta ttctcagacg      240

tattttcgtt ttcaggaaga aattaaagaa aacaccaaaa atgacaaaca gatggtgcag      300

tacatttaca aatacaccag ttacccggac ccgattctgc tgatgaaaag cgcccgtaac      360

tcatgctgga gcaaagacgc tgaatatggc ctgtattcta tttatcaggg tggcatcttc      420

gaactgaaag aaaacgatcg tatttttgtt tcggtgacca acgaacacct gattgatatg      480

gatcatgaag catcgttttt cggcgcgttt ctggtcggc                             519


<210>  32
<211>  597
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  32
cgcaaacgta aaaaaagccg tggtggtggc ggtggcacca gcgaagaaac cattagcacc       60

gttcaggaaa aacagcagaa tattagtccg ctggttcgtg aacgtggtcc gcagcgtgtt      120

gcagcacata ttaccggcac ccgtggtcgt agcaataccc tgagcagccc gaatagcaaa      180

aatgaaaaag cactgggtcg caaaattaat agctgggaaa gcagccgtag cggtcatagc      240

tttctgagca atctgcatct gcgtaatggt gaactggtga ttcatgaaaa aggcttttat      300

tatatttata gccagaccta ttttcgcttt caggaagaaa ttaaagaaaa taccaaaaat      360

gataaacaaa tggtgcagta tatctataaa tacaccagct atccggatcc gattctgctg      420

atgaaaagcg cacgtaatag ctgttggagc aaagatgcag aatatggtct gtatagcatt      480

tatcagggtg gcatttttga actgaaagaa aatgatcgca tttttgtgag cgtgaccaat      540

gaacatctga ttgatatgga tcatgaagcc agcttttttg gtgcatttct ggtgggt         597


<210>  33
<211>  690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  33
cgtaaacgta aaaaaagccg tggtggtggt ggcggtcgtg ttgcagcaca tattaccggc       60

acccgtggtc gtagcaatac cctgagcagc ccgaatagca aaaatgaaaa agcactgggt      120

cgcaaaatta atagctggga aagcagccgt agcggtcata gctttctgag caatctgcat      180

ctgcgtaatg gtgaactggt gattcatgaa aaaggctttt attatattta tagccagacc      240

tattttcgct ttcaggaaga aattaaagaa aataccaaaa atgataaaca aatggtgcag      300

tacatttaca aatataccag ctatccggat ccgattctgc tgatgaaaag cgcacgtaat      360

agctgttgga gcaaagatgc agaatatggt ctgtatagca tttatcaggg tggcattttt      420

gaactgaaag aaaatgatcg catttttgtg agcgtgacca atgaacatct gattgatatg      480

gatcatgaag ccagcttttt tggtgcattt ctggttggtg gcggtggtcc gctgggtctg      540

gcaggtcgtg ttgttcgtac catgccgttt ctgttttgca atgttaatga tgtgtgcaat      600

tttgccagcc gcaatgatta tagctattgg ctgtgcaatt attatagcaa tagctatagc      660

ttttggctgg ctagtctgaa tccggaacgt                                       690


<210>  34
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  34
cgcaaacgta aaaaaagccg tccgctgggt attgccggtg aacgtaaacg caaaaaatct       60

cgtggtggtg gtggcggtcg tgttgcagca catattaccg gcacccgtgg tcgtagcaat      120

accctgagca gcccgaatag caaaaatgaa aaagccctgg gtcgcaaaat taatagctgg      180

gaaagcagcc gtagcggtca tagctttctg agcaatctgc atctgcgtaa tggtgaactg      240

gtgattcatg aaaaaggctt ttattatatt tatagccaga cctattttcg ctttcaggaa      300

gaaattaaag aaaacaccaa aaatgataaa caaatggtgc agtatatcta taaatacacc      360

agctatccgg atccgattct gctgatgaaa agcgcacgta atagctgttg gagcaaagat      420

gcagaatatg gcctgtatag catttatcag ggtggcattt ttgaactgaa agaaaatgat      480

cgcatttttg tgagcgtgac caatgaacat ctgattgata tggatcatga agccagcttt      540

tttggtgcat ttctggtggg t                                                561


<210>  35
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  35
cgtaaacgta aaaaaagccg tgttgttcgt ccgctgggta ttgccggtga acgtaaacgc       60

aaaaaatcac gtggtggtcg tgttgcagca catattaccg gcacccgtgg tcgtagcaat      120

accctgagca gcccgaatag caaaaatgaa aaagcactgg gtcgcaaaat taatagctgg      180

gaaagcagcc gtagcggtca tagctttctg agcaatctgc atctgcgtaa tggtgaactg      240

gtgattcatg aaaaaggctt ttattatatt tatagccaga cctattttcg ctttcaggaa      300

gaaattaaag aaaataccaa aaatgataaa caaatggtgc agtacattta caaatatacc      360

agctatccgg atccgattct gctgatgaaa agcgcacgta atagctgttg gagcaaagat      420

gcagaatatg gtctgtatag catttatcag ggtggcattt ttgaactgaa agaaaatgat      480

cgcatttttg tgagcgtgac caatgaacat ctgattgata tggatcatga agccagcttt      540

tttggtgcat ttctggttgg t                                                561


<210>  36
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  36
cgtaaacgta aaaaaagccg tgttgttcgt ccgctgggta ttgcaggtga acgtaaacgt       60

aaaaaaagcc gtggtggtgg ttgtgcagca gcatgtgcag catgtaccag cgaagaaacc      120

attagcaccg ttcaggaaaa acagcagaat attagcccgc tggttcgtga acgtggtccg      180

cagcgtgttg cagcacatat taccggtacc cgtggtcgta gcaataccct gagcagcccg      240

aatagcaaaa atgaaaaagc actgggtcgt aaaattaata gctgggaaag cagccgtagc      300

ggtcatagct ttctgagcaa tctgcatctg cgtaatggtg aactggttat tcatgaaaaa      360

ggtttttatt atatttatag ccagacctat tttcgttttc aggaagaaat taaagaaaat      420

accaaaaatg ataaacagat ggttcagtat atttataaat ataccagcta tccggatccg      480

attctgctga tgaaaagcgc acgtaatagc tgttggagca aagatgcaga atatggtctg      540

tatagcattt atcagggtgg tatttttgaa ctgaaagaaa atgatcgtat ttttgttagc      600

gttaccaatg aacatctgat tgatatggat catgaagcaa gcttttttgg tgcatttctg      660

gttggt                                                                 666


<210>  37
<211>  505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  37
tgtaatggtc gttgtccgca gcgtgttgca gcacatatta ccggcacccg tggtcgtagc       60

aataccctga gcagcccgaa tagcaaaaat gaaaaagccc tgggtcgcaa aattaatagc      120

tgggaaagca gccgtagcgg tcatagcttt ctgagcaatc tgcatctgcg taatggtgaa      180

ctggtgattc atgaaaaagg cttttattat atttatagcc agacctattt tcgctttcag      240

gaagaaatta aagaaaacac caaaaatgat aaacaaatgg tgcagtatat ctataaatac      300

accagctatc cggatccgat tctgctgatg aaaagcgcac gtaatagctg ttggagcaaa      360

gatgcagaat atggcctgta tagcatttat cagggtggca tttttgaact gaaagaaaat      420

gatcgcattt ttgtgagcgt gaccaatgaa catctgattg atatggatca tgaaagccag      480

cttttttggt gcatttctgg tgggt                                            505


<210>  38
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  38
tgtgaatgtg gcggtgaatg tttttgtggt ggcggtagca ccagtgaaga aaccattagc       60

accgttcaag aaaaacagca gaatattagt ccgctggttc gtgaacgtgg tccgcagcgt      120

gttgcagcac atattaccgg cacccgtggt cgtagcaata ccctgagcag cccgaatagc      180

aaaaatgaaa aagcactggg tcgcaaaatc aatagctggg aaagcagccg tagcggtcat      240

agctttctga gcaatctgca tctgcgtaat ggtgaactgg tgattcatga aaaaggcttc      300

tactatatct acagccagac ctattttcgc ttccaagaag aaatcaaaga gaacaccaaa      360

aacgacaaac aaatggtgca gtacatctac aaatatacca gctatccgga tccgattctg      420

ctgatgaaaa gcgcacgtaa tagctgttgg agcaaagatg cagaatatgg tctgtatagc      480

atttatcagg gtggcatctt tgagctgaaa gaaaatgatc gcatctttgt tagcgtgacc      540

aacgaacatc tgatcgatat ggatcatgaa gccagctttt ttggtgcatt tctggtgggt      600


<210>  39
<211>  576
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  39
tatggtcgtc cgcgtcagag cggtaaaaaa cgtaaacgta aacgcctgaa accgacccgt       60

gttgttcgtc cgctgggtct ggcaggtccg cagcgtgttg cagcacatat taccggcacc      120

cgtggtcgta gcaataccct gagcagcccg aatagcaaaa atgaaaaagc cctgggtcgt      180

aaaattaata gctgggaaag cagccgtagc ggtcatagct ttctgagcaa tctgcatctg      240

cgtaatggcg aactggtgat tcatgaaaaa ggcttttatt atatttatag ccagacctat      300

tttcgctttc aggaagaaat taaagaaaat accaaaaatg ataaacaaat ggtgcagtat      360

atctataaat ataccagcta tccggatccg attctgctga tgaaaagcgc acgtaatagc      420

tgttggagca aagatgccga atatggtctg tatagcattt atcagggtgg catttttgaa      480

ctgaaagaaa atgatcgcat ttttgtgagc gtgaccaatg aacatctgat tgatatggat      540

catgaagcca gcttttttgg tgcatttctg gttggt                                576


<210>  40
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  40
tatggtcgtc cgcgtcagag cggtaaaaaa cgtaaacgta aacgcctgaa accgacccgt       60

gttgttcgtc cgctgggtct ggcaggcacc agcgaagaaa ccattagcac cgttcaggaa      120

aaacagcaga atattagtcc gctggttcgt gaacgtggtc cgcagcgtgt tgcagcacat      180

attaccggca cccgtggtcg tagcaatacc ctgagcagcc cgaatagcaa aaatgaaaaa      240

gcactgggtc gcaaaattaa tagctgggaa agcagccgta gcggtcatag ctttctgagc      300

aatctgcatc tgcgtaatgg tgaactggtg attcatgaaa aaggctttta ttatatttat      360

agccagacct attttcgctt tcaggaagaa attaaagaaa ataccaaaaa tgataaacaa      420

atggtgcagt atatctataa atacaccagc tatccggatc cgattctgct gatgaaaagc      480

gcacgtaata gctgttggag caaagatgca gaatatggtc tgtatagcat ttatcagggt      540

ggcatttttg aactgaaaga aaatgatcgc atttttgtga gcgtgaccaa tgaacatctg      600

attgatatgg atcatgaagc cagctttttt ggtgcatttc tggtgggt                   648


<210>  41
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  41
tatggtcgtc cgcgtcagag cggtaaaaaa cgtaaacgta aacgtctgaa accgacccgt       60

gttgttcgtc cgctgggtct ggcaggtggt ggttgtgcag cagcatgtgc agcatgtacc      120

agcgaagaaa ccattagcac cgttcaggaa aaacagcaga atattagccc gctggttcgt      180

gaacgtggtc cgcagcgtgt tgcagcacat attaccggta cccgtggtcg tagcaatacc      240

ctgagcagcc cgaatagcaa aaatgaaaaa gcactgggtc gtaaaattaa tagctgggaa      300

agcagccgta gcggtcatag ctttctgagc aatctgcatc tgcgtaatgg tgaactggtt      360

attcatgaaa aaggttttta ttatatttat agccagacct attttcgttt tcaggaagaa      420

attaaagaaa ataccaaaaa tgataaacag atggttcagt atatttataa atataccagc      480

tatccggatc cgattctgct gatgaaaagc gcacgtaata gctgttggag caaagatgca      540

gaatatggtc tgtatagcat ttatcagggt ggtatttttg aactgaaaga aaatgatcgt      600

atttttgtta gcgttaccaa tgaacatctg attgatatgg atcatgaagc aagctttttt      660

ggtgcatttc tggttggt                                                    678


<210>  42
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  42
accatgccgt ttctgttttg caatgttaat gatgtgtgca attttgccag ccgcaatgat       60

tatagctatt ggctgtgcaa ttattatagc aatagctata gcttttggct ggcttctctg      120

aatccggaac gtgttgttcg tccgctgggt ctggcaggcg gtggtggtcg tgttgcagca      180

catattaccg gcacccgtgg tcgtagcaat accctgagca gcccgaatag caaaaatgaa      240

aaagcactgg gtcgcaaaat taatagctgg gaaagcagcc gtagcggtca tagctttctg      300

agcaatctgc atctgcgtaa tggtgaactg gtgattcatg aaaaaggctt ttattatatt      360

tatagccaga cctattttcg ctttcaggaa gaaattaaag aaaataccaa aaatgataaa      420

caaatggtgc agtacattta caaatatacc agctatccgg atccgattct gctgatgaaa      480

agcgcacgta atagctgttg gagcaaagat gcagaatatg gtctgtatag catttatcag      540

ggtggcattt ttgaactgaa agaaaatgat cgcatttttg tgagcgtgac caatgaacat      600

ctgattgata tggatcatga agccagcttt tttggtgcat ttctggttgg t               651


<210>  43
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  43
tgcaattatt atagcaatag ctatagcttt tggctggcaa gcctgaatcc ggaacgtgtt       60

gttcgtccgc tgggtctggc tgggggtggc ggtcgtgttg cagcacatat taccggcacc      120

cgtggtcgta gcaataccct gagcagcccg aatagcaaaa atgaaaaagc actgggtcgc      180

aaaattaata gctgggaaag cagccgtagc ggtcatagct ttctgagcaa tctgcatctg      240

cgtaatggtg aactggtgat tcatgaaaaa ggcttttatt atatttatag ccagacctat      300

tttcgctttc aggaagaaat taaagaaaat accaaaaatg ataaacaaat ggtgcagtac      360

atttacaaat ataccagcta tccggatccg attctgctga tgaaaagcgc acgtaatagc      420

tgttggagca aagatgcaga atatggtctg tatagcattt atcagggtgg catttttgaa      480

ctgaaagaaa atgatcgcat ttttgtgagc gtgaccaatg aacatctgat tgatatggat      540

catgaagcca gcttttttgg tgcatttctg gttggtggcg gtggtactat gccgtttctg      600

ttttgcaatg ttaatgatgt gtgcaatttt gccagccgca atgattatag ctattggctg      660


<210>  44
<211>  543
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  44
ctgggtctgc gtagcctgcg tgaacgtgtt gttcgtccgc tgggtctggc aggtccgcag       60

cgtgttgcag cacatattac cggcacccgt ggtcgtagca ataccctgag cagcccgaat      120

agcaaaaatg aaaaagccct gggtcgtaaa attaatagct gggaaagcag ccgtagcggt      180

catagctttc tgagcaatct gcatctgcgt aatggcgaac tggtgattca tgaaaaaggc      240

ttttattata tttatagcca gacctatttt cgctttcagg aagaaattaa agaaaatacc      300

aaaaatgata aacaaatggt gcagtatatc tataaatata ccagctatcc ggatccgatt      360

ctgctgatga aaagcgcacg taatagctgt tggagcaaag atgccgaata tggtctgtat      420

agcatttatc agggtggcat ttttgaactg aaagaaaatg atcgcatttt tgtgagcgtg      480

accaatgaac atctgattga tatggatcat gaagccagct tttttggtgc atttctggtt      540

ggt                                                                    543


<210>  45
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct

<400>  45
ctgggtctgc gtagcctgcg tgaacgtgtt gttcgtccgc tgggtctggc aggtccgggt       60

ggtggttgtg cagcagcatg tgcagcatgt accagcgaag aaaccattag caccgttcag      120

gaaaaacagc agaatattag cccgctggtt cgtgaacgtg gtccgcagcg tgttgcagca      180

catattaccg gtacccgtgg tcgtagcaat accctgagca gcccgaatag caaaaatgaa      240

aaagcactgg gtcgtaaaat taatagctgg gaaagcagcc gtagcggtca tagctttctg      300

agcaatctgc atctgcgtaa tggtgaactg gttattcatg aaaaaggttt ttattatatt      360

tatagccaga cctattttcg ttttcaggaa gaaattaaag aaaataccaa aaatgataaa      420

cagatggttc agtatattta taaatatacc agctatccgg atccgattct gctgatgaaa      480

agcgcacgta atagctgttg gagcaaagat gcagaatatg gtctgtatag catttatcag      540

ggtggtattt ttgaactgaa agaaaatgat cgtatttttg ttagcgttac caatgaacat      600

ctgattgata tggatcatga agcaagcttt tttggtgcat ttctggttgg t               651


<210>  46
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  46

Arg Lys Arg Lys Lys Ser Arg Val Val Arg Pro Leu Gly Ile Ala Gly 
1               5                   10                  15      


Glu Arg Lys Arg Lys Lys Ser Arg Thr Ser Glu Glu Thr Ile Ser Thr 
            20                  25                  30          


Val Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly 
        35                  40                  45              


Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
    50                  55                  60                  


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
65                  70                  75                  80  


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
                85                  90                  95      


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
            100                 105                 110         


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
        115                 120                 125             


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
    130                 135                 140                 


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
145                 150                 155                 160 


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
                165                 170                 175     


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
            180                 185                 190         


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
        195                 200                 205             


Leu Val Gly 
    210     


<210>  47
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  47

Arg Lys Arg Lys Lys Ser Arg Val Val Arg Pro Leu Gly Ile Ala Gly 
1               5                   10                  15      


Glu Arg Lys Arg Lys Lys Ser Arg Gly Gly Gly Cys Ala Ala Ala Cys 
            20                  25                  30          


Ala Ala Cys Gly Ser Gly Gln Arg Val Ala Ala His Ile Thr Gly Thr 
        35                  40                  45              


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
    50                  55                  60                  


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
65                  70                  75                  80  


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
                85                  90                  95      


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
            100                 105                 110         


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
        115                 120                 125             


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
    130                 135                 140                 


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
145                 150                 155                 160 


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
                165                 170                 175     


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
            180                 185                 190         


Phe Phe Gly Ala Phe Leu Val Gly 
        195                 200 


<210>  48
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  48

Arg Lys Arg Lys Lys Ser Arg Val Val Arg Lys Arg Lys Lys Ser Arg 
1               5                   10                  15      


Gly Gly Gly Cys Ala Ala Ala Cys Ala Ala Cys Gly Ser Gly Gln Arg 
            20                  25                  30          


Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser 
        35                  40                  45              


Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser 
    50                  55                  60                  


Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu 
65                  70                  75                  80  


Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr 
                85                  90                  95      


Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys 
            100                 105                 110         


Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro 
        115                 120                 125             


Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys 
    130                 135                 140                 


Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu 
145                 150                 155                 160 


Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu 
                165                 170                 175     


Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
            180                 185                 190         


<210>  49
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  49

Tyr Gly Arg Pro Arg Gln Ser Gly Lys Lys Arg Lys Arg Lys Arg Leu 
1               5                   10                  15      


Lys Pro Thr Arg Val Val Arg Pro Leu Gly Ile Ala Gly Glu Gly Gly 
            20                  25                  30          


Gly Cys Ala Ala Ala Cys Ala Ala Cys Gly Ser Gly Gln Arg Val Ala 
        35                  40                  45              


Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro 
    50                  55                  60                  


Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu 
65                  70                  75                  80  


Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn 
                85                  90                  95      


Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln 
            100                 105                 110         


Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp 
        115                 120                 125             


Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro 
    130                 135                 140                 


Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala 
145                 150                 155                 160 


Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys 
                165                 170                 175     


Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp 
            180                 185                 190         


Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
        195                 200                 205     


<210>  50
<211>  633
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  50
cgtaaacgta aaaaaagccg tgtggtgcgt ccgctgggca ttgcgggcga acgtaaacgt       60

aaaaaaagcc gtaccagcga agaaaccatt agcaccgtgc aggaaaaaca gcagaacatt      120

agcccgctgg tgcgtgaacg tggcccgcag cgtgtggcgg cgcatattac cggcacccgt      180

ggccgtagca acaccctgag cagcccgaac agcaaaaacg aaaaagcgct gggccgtaaa      240

attaacagct gggaaagcag ccgtagcggc catagctttc tgagcaacct gcatctgcgt      300

aacggcgaac tggtgattca tgaaaaaggc ttttattata tttatagcca gacctatttt      360

cgttttcagg aagaaattaa agaaaacacc aaaaacgata aacagatggt gcagtatatt      420

tataaatata ccagctatcc ggatccgatt ctgctgatga aaagcgcgcg taacagctgc      480

tggagcaaag atgcggaata tggcctgtat agcatttatc agggcggcat ttttgaactg      540

aaagaaaacg atcgtatttt tgtgagcgtg accaacgaac atctgattga tatggatcat      600

gaagcgagct tttttggcgc gtttctggtg ggc                                   633


<210>  51
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  51
cgtaaacgta aaaaaagccg tgttgttcgt ccgctgggta ttgccggtga acgtaaacgc       60

aaaaaatcac gtggtggtgg ttgtgcagca gcatgtgcag cctgtggtag cggtcagcgt      120

gttgcagcac atattaccgg cacccgtggt cgtagcaata ccctgagcag cccgaatagc      180

aaaaatgaaa aagcactggg tcgcaaaatt aacagctggg aaagcagccg tagcggtcat      240

agctttctga gcaatctgca tctgcgtaat ggtgaactgg tgattcatga aaaaggcttt      300

tactacatct acagccagac ctatttccgc tttcaagaag agattaaaga aaataccaaa      360

aatgataaac aaatggtgca gtatatttac aaatatacca gctatccgga tccgatcctg      420

ctgatgaaaa gcgcacgtaa tagctgttgg agcaaagatg cagaatatgg cctgtatagc      480

atttatcagg gtggcatctt tgaactgaaa gaaaacgatc gtattttcgt gagcgtgacc      540

aatgaacatc tgatcgatat ggatcatgaa gccagctttt ttggtgcatt tctggtgggt      600


<210>  52
<211>  576
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  52
cgtaaacgta aaaaaagccg tgttgtgcgc aaacgcaaaa aatcacgtgg tggtggttgt       60

gcagcagcat gtgcagcctg tggtagcggt cagcgtgttg cagcacatat taccggcacc      120

cgtggtcgta gcaataccct gagcagcccg aatagcaaaa atgaaaaagc actgggtcgc      180

aaaattaaca gctgggaaag cagccgtagc ggtcatagct ttctgagcaa tctgcatctg      240

cgtaatggtg aactggtgat tcatgaaaaa ggcttttact acatctacag ccagacctat      300

ttccgctttc aagaagagat taaagaaaat accaaaaatg ataaacaaat ggtgcagtat      360

atttacaaat ataccagcta tccggatccg atcctgctga tgaaaagcgc acgtaatagc      420

tgttggagca aagatgcaga atatggcctg tatagcattt atcagggtgg catctttgaa      480

ctgaaagaaa acgatcgtat tttcgtgagc gtgaccaatg aacatctgat cgatatggat      540

catgaagcca gcttttttgg tgcatttctg gtgggt                                576


<210>  53
<211>  676
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  53
tatggtcgtc cgcgtcagag cggtaaaaaa cgtaaacgta aacgcctgaa accgacccgt       60

gttgttcgtc cgctgggtat tgccggtgaa ggtggtggtt gtgcagcagc atgtgcagcc      120

tgtggtagcg gtcagcgtgt tgcagcacat attaccggca cccgtggtcg tagcaatacc      180

ctgagcagcc cgaatagcaa aaatgaaaaa gcactgggtc gcaaaatcaa tagctgggaa      240

agcagccgta gcggtcatag ctttctgagc aatctgcatc tgcgtaatgg tgaactggtg      300

attcatgaaa aaggctttta ttacatttat agccagacct atttccgctt tcaagaagaa      360

attaaagaaa ataccaaaaa tgataaacaa atggtgcagt atatttacaa atataccagc      420

tatccggatc cgattctgct gatgaaaagc gcacgtaata gctgttggag caaagatgca      480

gaatatggtc tgtatagcat ttatcagggt ggcatttttg aactgaaaga aaatgatcgc      540

atttttgtga gcgtgaccaa tgaacatctg attgatatgg atcatgaagc cagctttttt      600

ggtgcatttc tggtgggtta ataactcgag ggtacctgga gcacaagact ggcctcatgg      660

gccttccgct cactgc                                                      676


<210>  54
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible linker

<400>  54

Cys Gly Ser Gly 
1               


<210>  55
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  55

Pro Leu Gly Ile Ala Gly Glu 
1               5           


<210>  56
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  56

Pro Leu Gly Leu Ala Gly Glu Pro 
1               5               


