                         SEQUENCE LISTING

<110>  Krizman, David B.
       Darfler, Marlene M
       Conrads, Thomas P
       Hood, Brian L
       Bateman, Nicholas W
 
<120>  PROTEIN BIOMARKERS OF LATE STAGE BREAST CANCER

<130>  01152.8022.WO00

<150>  US 61/428,160
<151>  2010-12-29

<160>  113   

<170>  PatentIn version 3.5

<210>  1
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Ala Thr Leu Arg Pro Tyr Leu Ser Ala Val Arg Ala Thr Leu 
1               5                   10                  15      


Gln Ala Ala Leu Cys Leu Glu Asn Phe Ser Ser Gln Val Val Glu Arg 
            20                  25                  30          


His Asn Lys Pro Glu Val Glu Val Arg Ser Ser Lys Glu Leu Leu Leu 
        35                  40                  45              


Gln Pro Val Thr Ile Ser Arg Asn Glu Lys Glu Lys Val Leu Ile Glu 
    50                  55                  60                  


Gly Ser Ile Asn Ser Val Arg Val Ser Ile Ala Val Lys Gln Ala Asp 
65                  70                  75                  80  


Glu Ile Glu Lys Ile Leu Cys His Lys Phe Met Arg Phe Met Met Met 
                85                  90                  95      


Arg Ala Glu Asn Phe Phe Ile Leu Arg Arg Lys Pro Val Glu Gly Tyr 
            100                 105                 110         


Asp Ile Ser Phe Leu Ile Thr Asn Phe His Thr Glu Gln Met Tyr Lys 
        115                 120                 125             


His Lys Leu Val Asp Phe Val Ile His Phe Met Glu Glu Ile Asp Lys 
    130                 135                 140                 


Glu Ile Ser Glu Met Lys Leu Ser Val Asn Ala Arg Ala Arg Ile Val 
145                 150                 155                 160 


Ala Glu Glu Phe Leu Lys Asn Phe 
                165             


<210>  2
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210>  3
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gln Ala Ala Arg Met Ala Ala Ser Leu Gly Arg Gln Leu Leu Arg 
1               5                   10                  15      


Leu Gly Gly Gly Ser Ser Arg Leu Thr Ala Leu Leu Gly Gln Pro Arg 
            20                  25                  30          


Pro Gly Pro Ala Arg Arg Pro Tyr Ala Gly Gly Ala Ala Gln Leu Ala 
        35                  40                  45              


Leu Asp Lys Ser Asp Ser His Pro Ser Asp Ala Leu Thr Arg Lys Lys 
    50                  55                  60                  


Pro Ala Lys Ala Glu Ser Lys Ser Phe Ala Val Gly Met Phe Lys Gly 
65                  70                  75                  80  


Gln Leu Thr Thr Asp Gln Val Phe Pro Tyr Pro Ser Val Leu Asn Glu 
                85                  90                  95      


Glu Gln Thr Gln Phe Leu Lys Glu Leu Val Glu Pro Val Ser Arg Phe 
            100                 105                 110         


Phe Glu Glu Val Asn Asp Pro Ala Lys Asn Asp Ala Leu Glu Met Val 
        115                 120                 125             


Glu Glu Thr Thr Trp Gln Gly Leu Lys Glu Leu Gly Ala Phe Gly Leu 
    130                 135                 140                 


Gln Val Pro Ser Glu Leu Gly Gly Val Gly Leu Cys Asn Thr Gln Tyr 
145                 150                 155                 160 


Ala Arg Leu Val Glu Ile Val Gly Met His Asp Leu Gly Val Gly Ile 
                165                 170                 175     


Thr Leu Gly Ala His Gln Ser Ile Gly Phe Lys Gly Ile Leu Leu Phe 
            180                 185                 190         


Gly Thr Lys Ala Gln Lys Glu Lys Tyr Leu Pro Lys Leu Ala Ser Gly 
        195                 200                 205             


Glu Thr Val Ala Ala Phe Cys Leu Thr Glu Pro Ser Ser Gly Ser Asp 
    210                 215                 220                 


Ala Ala Ser Ile Arg Thr Ser Ala Val Pro Ser Pro Cys Gly Lys Tyr 
225                 230                 235                 240 


Tyr Thr Leu Asn Gly Ser Lys Leu Trp Ile Ser Asn Gly Gly Leu Ala 
                245                 250                 255     


Asp Ile Phe Thr Val Phe Ala Lys Thr Pro Val Thr Asp Pro Ala Thr 
            260                 265                 270         


Gly Ala Val Lys Glu Lys Ile Thr Ala Phe Val Val Glu Arg Gly Phe 
        275                 280                 285             


Gly Gly Ile Thr His Gly Pro Pro Glu Lys Lys Met Gly Ile Lys Ala 
    290                 295                 300                 


Ser Asn Thr Ala Glu Val Phe Phe Asp Gly Val Arg Val Pro Ser Glu 
305                 310                 315                 320 


Asn Val Leu Gly Glu Val Gly Ser Gly Phe Lys Val Ala Met His Ile 
                325                 330                 335     


Leu Asn Asn Gly Arg Phe Gly Met Ala Ala Ala Leu Ala Gly Thr Met 
            340                 345                 350         


Arg Gly Ile Ile Ala Lys Ala Val Asp His Ala Thr Asn Arg Thr Gln 
        355                 360                 365             


Phe Gly Glu Lys Ile His Asn Phe Gly Leu Ile Gln Glu Lys Leu Ala 
    370                 375                 380                 


Arg Met Val Met Leu Gln Tyr Val Thr Glu Ser Met Ala Tyr Met Val 
385                 390                 395                 400 


Ser Ala Asn Met Asp Gln Gly Ala Thr Asp Phe Gln Ile Glu Ala Ala 
                405                 410                 415     


Ile Ser Lys Ile Phe Gly Ser Glu Ala Ala Trp Lys Val Thr Asp Glu 
            420                 425                 430         


Cys Ile Gln Ile Met Gly Gly Met Gly Phe Met Lys Glu Pro Gly Val 
        435                 440                 445             


Glu Arg Val Leu Arg Asp Leu Arg Ile Phe Arg Ile Phe Glu Gly Thr 
    450                 455                 460                 


Asn Asp Ile Leu Arg Leu Phe Val Ala Leu Gln Gly Cys Met Asp Lys 
465                 470                 475                 480 


Gly Lys Glu Leu Ser Gly Leu Gly Ser Ala Leu Lys Asn Pro Phe Gly 
                485                 490                 495     


Asn Ala Gly Leu Leu Leu Gly Glu Ala Gly Lys Gln Leu Arg Arg Arg 
            500                 505                 510         


Ala Gly Leu Gly Ser Gly Leu Ser Leu Ser Gly Leu Val His Pro Glu 
        515                 520                 525             


Leu Ser Arg Ser Gly Glu Leu Ala Val Arg Ala Leu Glu Gln Phe Ala 
    530                 535                 540                 


Thr Val Val Glu Ala Lys Leu Ile Lys His Lys Lys Gly Ile Val Asn 
545                 550                 555                 560 


Glu Gln Phe Leu Leu Gln Arg Leu Ala Asp Gly Ala Ile Asp Leu Tyr 
                565                 570                 575     


Ala Met Val Val Val Leu Ser Arg Ala Ser Arg Ser Leu Ser Glu Gly 
            580                 585                 590         


His Pro Thr Ala Gln His Glu Lys Met Leu Cys Asp Thr Trp Cys Ile 
        595                 600                 605             


Glu Ala Ala Ala Arg Ile Arg Glu Gly Met Ala Ala Leu Gln Ser Asp 
    610                 615                 620                 


Pro Trp Gln Gln Glu Leu Tyr Arg Asn Phe Lys Ser Ile Ser Lys Ala 
625                 630                 635                 640 


Leu Val Glu Arg Gly Gly Val Val Thr Ser Asn Pro Leu Gly Phe 
                645                 650                 655 


<210>  4
<211>  2843
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ala Ala Ser Tyr Asp Gln Leu Leu Lys Gln Val Glu Ala Leu 
1               5                   10                  15      


Lys Met Glu Asn Ser Asn Leu Arg Gln Glu Leu Glu Asp Asn Ser Asn 
            20                  25                  30          


His Leu Thr Lys Leu Glu Thr Glu Ala Ser Asn Met Lys Glu Val Leu 
        35                  40                  45              


Lys Gln Leu Gln Gly Ser Ile Glu Asp Glu Ala Met Ala Ser Ser Gly 
    50                  55                  60                  


Gln Ile Asp Leu Leu Glu Arg Leu Lys Glu Leu Asn Leu Asp Ser Ser 
65                  70                  75                  80  


Asn Phe Pro Gly Val Lys Leu Arg Ser Lys Met Ser Leu Arg Ser Tyr 
                85                  90                  95      


Gly Ser Arg Glu Gly Ser Val Ser Ser Arg Ser Gly Glu Cys Ser Pro 
            100                 105                 110         


Val Pro Met Gly Ser Phe Pro Arg Arg Gly Phe Val Asn Gly Ser Arg 
        115                 120                 125             


Glu Ser Thr Gly Tyr Leu Glu Glu Leu Glu Lys Glu Arg Ser Leu Leu 
    130                 135                 140                 


Leu Ala Asp Leu Asp Lys Glu Glu Lys Glu Lys Asp Trp Tyr Tyr Ala 
145                 150                 155                 160 


Gln Leu Gln Asn Leu Thr Lys Arg Ile Asp Ser Leu Pro Leu Thr Glu 
                165                 170                 175     


Asn Phe Ser Leu Gln Thr Asp Met Thr Arg Arg Gln Leu Glu Tyr Glu 
            180                 185                 190         


Ala Arg Gln Ile Arg Val Ala Met Glu Glu Gln Leu Gly Thr Cys Gln 
        195                 200                 205             


Asp Met Glu Lys Arg Ala Gln Arg Arg Ile Ala Arg Ile Gln Gln Ile 
    210                 215                 220                 


Glu Lys Asp Ile Leu Arg Ile Arg Gln Leu Leu Gln Ser Gln Ala Thr 
225                 230                 235                 240 


Glu Ala Glu Arg Ser Ser Gln Asn Lys His Glu Thr Gly Ser His Asp 
                245                 250                 255     


Ala Glu Arg Gln Asn Glu Gly Gln Gly Val Gly Glu Ile Asn Met Ala 
            260                 265                 270         


Thr Ser Gly Asn Gly Gln Gly Ser Thr Thr Arg Met Asp His Glu Thr 
        275                 280                 285             


Ala Ser Val Leu Ser Ser Ser Ser Thr His Ser Ala Pro Arg Arg Leu 
    290                 295                 300                 


Thr Ser His Leu Gly Thr Lys Val Glu Met Val Tyr Ser Leu Leu Ser 
305                 310                 315                 320 


Met Leu Gly Thr His Asp Lys Asp Asp Met Ser Arg Thr Leu Leu Ala 
                325                 330                 335     


Met Ser Ser Ser Gln Asp Ser Cys Ile Ser Met Arg Gln Ser Gly Cys 
            340                 345                 350         


Leu Pro Leu Leu Ile Gln Leu Leu His Gly Asn Asp Lys Asp Ser Val 
        355                 360                 365             


Leu Leu Gly Asn Ser Arg Gly Ser Lys Glu Ala Arg Ala Arg Ala Ser 
    370                 375                 380                 


Ala Ala Leu His Asn Ile Ile His Ser Gln Pro Asp Asp Lys Arg Gly 
385                 390                 395                 400 


Arg Arg Glu Ile Arg Val Leu His Leu Leu Glu Gln Ile Arg Ala Tyr 
                405                 410                 415     


Cys Glu Thr Cys Trp Glu Trp Gln Glu Ala His Glu Pro Gly Met Asp 
            420                 425                 430         


Gln Asp Lys Asn Pro Met Pro Ala Pro Val Glu His Gln Ile Cys Pro 
        435                 440                 445             


Ala Val Cys Val Leu Met Lys Leu Ser Phe Asp Glu Glu His Arg His 
    450                 455                 460                 


Ala Met Asn Glu Leu Gly Gly Leu Gln Ala Ile Ala Glu Leu Leu Gln 
465                 470                 475                 480 


Val Asp Cys Glu Met Tyr Gly Leu Thr Asn Asp His Tyr Ser Ile Thr 
                485                 490                 495     


Leu Arg Arg Tyr Ala Gly Met Ala Leu Thr Asn Leu Thr Phe Gly Asp 
            500                 505                 510         


Val Ala Asn Lys Ala Thr Leu Cys Ser Met Lys Gly Cys Met Arg Ala 
        515                 520                 525             


Leu Val Ala Gln Leu Lys Ser Glu Ser Glu Asp Leu Gln Gln Val Ile 
    530                 535                 540                 


Ala Ser Val Leu Arg Asn Leu Ser Trp Arg Ala Asp Val Asn Ser Lys 
545                 550                 555                 560 


Lys Thr Leu Arg Glu Val Gly Ser Val Lys Ala Leu Met Glu Cys Ala 
                565                 570                 575     


Leu Glu Val Lys Lys Glu Ser Thr Leu Lys Ser Val Leu Ser Ala Leu 
            580                 585                 590         


Trp Asn Leu Ser Ala His Cys Thr Glu Asn Lys Ala Asp Ile Cys Ala 
        595                 600                 605             


Val Asp Gly Ala Leu Ala Phe Leu Val Gly Thr Leu Thr Tyr Arg Ser 
    610                 615                 620                 


Gln Thr Asn Thr Leu Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg 
625                 630                 635                 640 


Asn Val Ser Ser Leu Ile Ala Thr Asn Glu Asp His Arg Gln Ile Leu 
                645                 650                 655     


Arg Glu Asn Asn Cys Leu Gln Thr Leu Leu Gln His Leu Lys Ser His 
            660                 665                 670         


Ser Leu Thr Ile Val Ser Asn Ala Cys Gly Thr Leu Trp Asn Leu Ser 
        675                 680                 685             


Ala Arg Asn Pro Lys Asp Gln Glu Ala Leu Trp Asp Met Gly Ala Val 
    690                 695                 700                 


Ser Met Leu Lys Asn Leu Ile His Ser Lys His Lys Met Ile Ala Met 
705                 710                 715                 720 


Gly Ser Ala Ala Ala Leu Arg Asn Leu Met Ala Asn Arg Pro Ala Lys 
                725                 730                 735     


Tyr Lys Asp Ala Asn Ile Met Ser Pro Gly Ser Ser Leu Pro Ser Leu 
            740                 745                 750         


His Val Arg Lys Gln Lys Ala Leu Glu Ala Glu Leu Asp Ala Gln His 
        755                 760                 765             


Leu Ser Glu Thr Phe Asp Asn Ile Asp Asn Leu Ser Pro Lys Ala Ser 
    770                 775                 780                 


His Arg Ser Lys Gln Arg His Lys Gln Ser Leu Tyr Gly Asp Tyr Val 
785                 790                 795                 800 


Phe Asp Thr Asn Arg His Asp Asp Asn Arg Ser Asp Asn Phe Asn Thr 
                805                 810                 815     


Gly Asn Met Thr Val Leu Ser Pro Tyr Leu Asn Thr Thr Val Leu Pro 
            820                 825                 830         


Ser Ser Ser Ser Ser Arg Gly Ser Leu Asp Ser Ser Arg Ser Glu Lys 
        835                 840                 845             


Asp Arg Ser Leu Glu Arg Glu Arg Gly Ile Gly Leu Gly Asn Tyr His 
    850                 855                 860                 


Pro Ala Thr Glu Asn Pro Gly Thr Ser Ser Lys Arg Gly Leu Gln Ile 
865                 870                 875                 880 


Ser Thr Thr Ala Ala Gln Ile Ala Lys Val Met Glu Glu Val Ser Ala 
                885                 890                 895     


Ile His Thr Ser Gln Glu Asp Arg Ser Ser Gly Ser Thr Thr Glu Leu 
            900                 905                 910         


His Cys Val Thr Asp Glu Arg Asn Ala Leu Arg Arg Ser Ser Ala Ala 
        915                 920                 925             


His Thr His Ser Asn Thr Tyr Asn Phe Thr Lys Ser Glu Asn Ser Asn 
    930                 935                 940                 


Arg Thr Cys Ser Met Pro Tyr Ala Lys Leu Glu Tyr Lys Arg Ser Ser 
945                 950                 955                 960 


Asn Asp Ser Leu Asn Ser Val Ser Ser Ser Asp Gly Tyr Gly Lys Arg 
                965                 970                 975     


Gly Gln Met Lys Pro Ser Ile Glu Ser Tyr Ser Glu Asp Asp Glu Ser 
            980                 985                 990         


Lys Phe Cys Ser Tyr Gly Gln Tyr  Pro Ala Asp Leu Ala  His Lys Ile 
        995                 1000                 1005             


His Ser  Ala Asn His Met Asp  Asp Asn Asp Gly Glu  Leu Asp Thr 
    1010                 1015                 1020             


Pro Ile  Asn Tyr Ser Leu Lys  Tyr Ser Asp Glu Gln  Leu Asn Ser 
    1025                 1030                 1035             


Gly Arg  Gln Ser Pro Ser Gln  Asn Glu Arg Trp Ala  Arg Pro Lys 
    1040                 1045                 1050             


His Ile  Ile Glu Asp Glu Ile  Lys Gln Ser Glu Gln  Arg Gln Ser 
    1055                 1060                 1065             


Arg Asn  Gln Ser Thr Thr Tyr  Pro Val Tyr Thr Glu  Ser Thr Asp 
    1070                 1075                 1080             


Asp Lys  His Leu Lys Phe Gln  Pro His Phe Gly Gln  Gln Glu Cys 
    1085                 1090                 1095             


Val Ser  Pro Tyr Arg Ser Arg  Gly Ala Asn Gly Ser  Glu Thr Asn 
    1100                 1105                 1110             


Arg Val  Gly Ser Asn His Gly  Ile Asn Gln Asn Val  Ser Gln Ser 
    1115                 1120                 1125             


Leu Cys  Gln Glu Asp Asp Tyr  Glu Asp Asp Lys Pro  Thr Asn Tyr 
    1130                 1135                 1140             


Ser Glu  Arg Tyr Ser Glu Glu  Glu Gln His Glu Glu  Glu Glu Arg 
    1145                 1150                 1155             


Pro Thr  Asn Tyr Ser Ile Lys  Tyr Asn Glu Glu Lys  Arg His Val 
    1160                 1165                 1170             


Asp Gln  Pro Ile Asp Tyr Ser  Leu Lys Tyr Ala Thr  Asp Ile Pro 
    1175                 1180                 1185             


Ser Ser  Gln Lys Gln Ser Phe  Ser Phe Ser Lys Ser  Ser Ser Gly 
    1190                 1195                 1200             


Gln Ser  Ser Lys Thr Glu His  Met Ser Ser Ser Ser  Glu Asn Thr 
    1205                 1210                 1215             


Ser Thr  Pro Ser Ser Asn Ala  Lys Arg Gln Asn Gln  Leu His Pro 
    1220                 1225                 1230             


Ser Ser  Ala Gln Ser Arg Ser  Gly Gln Pro Gln Lys  Ala Ala Thr 
    1235                 1240                 1245             


Cys Lys  Val Ser Ser Ile Asn  Gln Glu Thr Ile Gln  Thr Tyr Cys 
    1250                 1255                 1260             


Val Glu  Asp Thr Pro Ile Cys  Phe Ser Arg Cys Ser  Ser Leu Ser 
    1265                 1270                 1275             


Ser Leu  Ser Ser Ala Glu Asp  Glu Ile Gly Cys Asn  Gln Thr Thr 
    1280                 1285                 1290             


Gln Glu  Ala Asp Ser Ala Asn  Thr Leu Gln Ile Ala  Glu Ile Lys 
    1295                 1300                 1305             


Glu Lys  Ile Gly Thr Arg Ser  Ala Glu Asp Pro Val  Ser Glu Val 
    1310                 1315                 1320             


Pro Ala  Val Ser Gln His Pro  Arg Thr Lys Ser Ser  Arg Leu Gln 
    1325                 1330                 1335             


Gly Ser  Ser Leu Ser Ser Glu  Ser Ala Arg His Lys  Ala Val Glu 
    1340                 1345                 1350             


Phe Ser  Ser Gly Ala Lys Ser  Pro Ser Lys Ser Gly  Ala Gln Thr 
    1355                 1360                 1365             


Pro Lys  Ser Pro Pro Glu His  Tyr Val Gln Glu Thr  Pro Leu Met 
    1370                 1375                 1380             


Phe Ser  Arg Cys Thr Ser Val  Ser Ser Leu Asp Ser  Phe Glu Ser 
    1385                 1390                 1395             


Arg Ser  Ile Ala Ser Ser Val  Gln Ser Glu Pro Cys  Ser Gly Met 
    1400                 1405                 1410             


Val Ser  Gly Ile Ile Ser Pro  Ser Asp Leu Pro Asp  Ser Pro Gly 
    1415                 1420                 1425             


Gln Thr  Met Pro Pro Ser Arg  Ser Lys Thr Pro Pro  Pro Pro Pro 
    1430                 1435                 1440             


Gln Thr  Ala Gln Thr Lys Arg  Glu Val Pro Lys Asn  Lys Ala Pro 
    1445                 1450                 1455             


Thr Ala  Glu Lys Arg Glu Ser  Gly Pro Lys Gln Ala  Ala Val Asn 
    1460                 1465                 1470             


Ala Ala  Val Gln Arg Val Gln  Val Leu Pro Asp Ala  Asp Thr Leu 
    1475                 1480                 1485             


Leu His  Phe Ala Thr Glu Ser  Thr Pro Asp Gly Phe  Ser Cys Ser 
    1490                 1495                 1500             


Ser Ser  Leu Ser Ala Leu Ser  Leu Asp Glu Pro Phe  Ile Gln Lys 
    1505                 1510                 1515             


Asp Val  Glu Leu Arg Ile Met  Pro Pro Val Gln Glu  Asn Asp Asn 
    1520                 1525                 1530             


Gly Asn  Glu Thr Glu Ser Glu  Gln Pro Lys Glu Ser  Asn Glu Asn 
    1535                 1540                 1545             


Gln Glu  Lys Glu Ala Glu Lys  Thr Ile Asp Ser Glu  Lys Asp Leu 
    1550                 1555                 1560             


Leu Asp  Asp Ser Asp Asp Asp  Asp Ile Glu Ile Leu  Glu Glu Cys 
    1565                 1570                 1575             


Ile Ile  Ser Ala Met Pro Thr  Lys Ser Ser Arg Lys  Ala Lys Lys 
    1580                 1585                 1590             


Pro Ala  Gln Thr Ala Ser Lys  Leu Pro Pro Pro Val  Ala Arg Lys 
    1595                 1600                 1605             


Pro Ser  Gln Leu Pro Val Tyr  Lys Leu Leu Pro Ser  Gln Asn Arg 
    1610                 1615                 1620             


Leu Gln  Pro Gln Lys His Val  Ser Phe Thr Pro Gly  Asp Asp Met 
    1625                 1630                 1635             


Pro Arg  Val Tyr Cys Val Glu  Gly Thr Pro Ile Asn  Phe Ser Thr 
    1640                 1645                 1650             


Ala Thr  Ser Leu Ser Asp Leu  Thr Ile Glu Ser Pro  Pro Asn Glu 
    1655                 1660                 1665             


Leu Ala  Ala Gly Glu Gly Val  Arg Gly Gly Ala Gln  Ser Gly Glu 
    1670                 1675                 1680             


Phe Glu  Lys Arg Asp Thr Ile  Pro Thr Glu Gly Arg  Ser Thr Asp 
    1685                 1690                 1695             


Glu Ala  Gln Gly Gly Lys Thr  Ser Ser Val Thr Ile  Pro Glu Leu 
    1700                 1705                 1710             


Asp Asp  Asn Lys Ala Glu Glu  Gly Asp Ile Leu Ala  Glu Cys Ile 
    1715                 1720                 1725             


Asn Ser  Ala Met Pro Lys Gly  Lys Ser His Lys Pro  Phe Arg Val 
    1730                 1735                 1740             


Lys Lys  Ile Met Asp Gln Val  Gln Gln Ala Ser Ala  Ser Ser Ser 
    1745                 1750                 1755             


Ala Pro  Asn Lys Asn Gln Leu  Asp Gly Lys Lys Lys  Lys Pro Thr 
    1760                 1765                 1770             


Ser Pro  Val Lys Pro Ile Pro  Gln Asn Thr Glu Tyr  Arg Thr Arg 
    1775                 1780                 1785             


Val Arg  Lys Asn Ala Asp Ser  Lys Asn Asn Leu Asn  Ala Glu Arg 
    1790                 1795                 1800             


Val Phe  Ser Asp Asn Lys Asp  Ser Lys Lys Gln Asn  Leu Lys Asn 
    1805                 1810                 1815             


Asn Ser  Lys Val Phe Asn Asp  Lys Leu Pro Asn Asn  Glu Asp Arg 
    1820                 1825                 1830             


Val Arg  Gly Ser Phe Ala Phe  Asp Ser Pro His His  Tyr Thr Pro 
    1835                 1840                 1845             


Ile Glu  Gly Thr Pro Tyr Cys  Phe Ser Arg Asn Asp  Ser Leu Ser 
    1850                 1855                 1860             


Ser Leu  Asp Phe Asp Asp Asp  Asp Val Asp Leu Ser  Arg Glu Lys 
    1865                 1870                 1875             


Ala Glu  Leu Arg Lys Ala Lys  Glu Asn Lys Glu Ser  Glu Ala Lys 
    1880                 1885                 1890             


Val Thr  Ser His Thr Glu Leu  Thr Ser Asn Gln Gln  Ser Ala Asn 
    1895                 1900                 1905             


Lys Thr  Gln Ala Ile Ala Lys  Gln Pro Ile Asn Arg  Gly Gln Pro 
    1910                 1915                 1920             


Lys Pro  Ile Leu Gln Lys Gln  Ser Thr Phe Pro Gln  Ser Ser Lys 
    1925                 1930                 1935             


Asp Ile  Pro Asp Arg Gly Ala  Ala Thr Asp Glu Lys  Leu Gln Asn 
    1940                 1945                 1950             


Phe Ala  Ile Glu Asn Thr Pro  Val Cys Phe Ser His  Asn Ser Ser 
    1955                 1960                 1965             


Leu Ser  Ser Leu Ser Asp Ile  Asp Gln Glu Asn Asn  Asn Lys Glu 
    1970                 1975                 1980             


Asn Glu  Pro Ile Lys Glu Thr  Glu Pro Pro Asp Ser  Gln Gly Glu 
    1985                 1990                 1995             


Pro Ser  Lys Pro Gln Ala Ser  Gly Tyr Ala Pro Lys  Ser Phe His 
    2000                 2005                 2010             


Val Glu  Asp Thr Pro Val Cys  Phe Ser Arg Asn Ser  Ser Leu Ser 
    2015                 2020                 2025             


Ser Leu  Ser Ile Asp Ser Glu  Asp Asp Leu Leu Gln  Glu Cys Ile 
    2030                 2035                 2040             


Ser Ser  Ala Met Pro Lys Lys  Lys Lys Pro Ser Arg  Leu Lys Gly 
    2045                 2050                 2055             


Asp Asn  Glu Lys His Ser Pro  Arg Asn Met Gly Gly  Ile Leu Gly 
    2060                 2065                 2070             


Glu Asp  Leu Thr Leu Asp Leu  Lys Asp Ile Gln Arg  Pro Asp Ser 
    2075                 2080                 2085             


Glu His  Gly Leu Ser Pro Asp  Ser Glu Asn Phe Asp  Trp Lys Ala 
    2090                 2095                 2100             


Ile Gln  Glu Gly Ala Asn Ser  Ile Val Ser Ser Leu  His Gln Ala 
    2105                 2110                 2115             


Ala Ala  Ala Ala Cys Leu Ser  Arg Gln Ala Ser Ser  Asp Ser Asp 
    2120                 2125                 2130             


Ser Ile  Leu Ser Leu Lys Ser  Gly Ile Ser Leu Gly  Ser Pro Phe 
    2135                 2140                 2145             


His Leu  Thr Pro Asp Gln Glu  Glu Lys Pro Phe Thr  Ser Asn Lys 
    2150                 2155                 2160             


Gly Pro  Arg Ile Leu Lys Pro  Gly Glu Lys Ser Thr  Leu Glu Thr 
    2165                 2170                 2175             


Lys Lys  Ile Glu Ser Glu Ser  Lys Gly Ile Lys Gly  Gly Lys Lys 
    2180                 2185                 2190             


Val Tyr  Lys Ser Leu Ile Thr  Gly Lys Val Arg Ser  Asn Ser Glu 
    2195                 2200                 2205             


Ile Ser  Gly Gln Met Lys Gln  Pro Leu Gln Ala Asn  Met Pro Ser 
    2210                 2215                 2220             


Ile Ser  Arg Gly Arg Thr Met  Ile His Ile Pro Gly  Val Arg Asn 
    2225                 2230                 2235             


Ser Ser  Ser Ser Thr Ser Pro  Val Ser Lys Lys Gly  Pro Pro Leu 
    2240                 2245                 2250             


Lys Thr  Pro Ala Ser Lys Ser  Pro Ser Glu Gly Gln  Thr Ala Thr 
    2255                 2260                 2265             


Thr Ser  Pro Arg Gly Ala Lys  Pro Ser Val Lys Ser  Glu Leu Ser 
    2270                 2275                 2280             


Pro Val  Ala Arg Gln Thr Ser  Gln Ile Gly Gly Ser  Ser Lys Ala 
    2285                 2290                 2295             


Pro Ser  Arg Ser Gly Ser Arg  Asp Ser Thr Pro Ser  Arg Pro Ala 
    2300                 2305                 2310             


Gln Gln  Pro Leu Ser Arg Pro  Ile Gln Ser Pro Gly  Arg Asn Ser 
    2315                 2320                 2325             


Ile Ser  Pro Gly Arg Asn Gly  Ile Ser Pro Pro Asn  Lys Leu Ser 
    2330                 2335                 2340             


Gln Leu  Pro Arg Thr Ser Ser  Pro Ser Thr Ala Ser  Thr Lys Ser 
    2345                 2350                 2355             


Ser Gly  Ser Gly Lys Met Ser  Tyr Thr Ser Pro Gly  Arg Gln Met 
    2360                 2365                 2370             


Ser Gln  Gln Asn Leu Thr Lys  Gln Thr Gly Leu Ser  Lys Asn Ala 
    2375                 2380                 2385             


Ser Ser  Ile Pro Arg Ser Glu  Ser Ala Ser Lys Gly  Leu Asn Gln 
    2390                 2395                 2400             


Met Asn  Asn Gly Asn Gly Ala  Asn Lys Lys Val Glu  Leu Ser Arg 
    2405                 2410                 2415             


Met Ser  Ser Thr Lys Ser Ser  Gly Ser Glu Ser Asp  Arg Ser Glu 
    2420                 2425                 2430             


Arg Pro  Val Leu Val Arg Gln  Ser Thr Phe Ile Lys  Glu Ala Pro 
    2435                 2440                 2445             


Ser Pro  Thr Leu Arg Arg Lys  Leu Glu Glu Ser Ala  Ser Phe Glu 
    2450                 2455                 2460             


Ser Leu  Ser Pro Ser Ser Arg  Pro Ala Ser Pro Thr  Arg Ser Gln 
    2465                 2470                 2475             


Ala Gln  Thr Pro Val Leu Ser  Pro Ser Leu Pro Asp  Met Ser Leu 
    2480                 2485                 2490             


Ser Thr  His Ser Ser Val Gln  Ala Gly Gly Trp Arg  Lys Leu Pro 
    2495                 2500                 2505             


Pro Asn  Leu Ser Pro Thr Ile  Glu Tyr Asn Asp Gly  Arg Pro Ala 
    2510                 2515                 2520             


Lys Arg  His Asp Ile Ala Arg  Ser His Ser Glu Ser  Pro Ser Arg 
    2525                 2530                 2535             


Leu Pro  Ile Asn Arg Ser Gly  Thr Trp Lys Arg Glu  His Ser Lys 
    2540                 2545                 2550             


His Ser  Ser Ser Leu Pro Arg  Val Ser Thr Trp Arg  Arg Thr Gly 
    2555                 2560                 2565             


Ser Ser  Ser Ser Ile Leu Ser  Ala Ser Ser Glu Ser  Ser Glu Lys 
    2570                 2575                 2580             


Ala Lys  Ser Glu Asp Glu Lys  His Val Asn Ser Ile  Ser Gly Thr 
    2585                 2590                 2595             


Lys Gln  Ser Lys Glu Asn Gln  Val Ser Ala Lys Gly  Thr Trp Arg 
    2600                 2605                 2610             


Lys Ile  Lys Glu Asn Glu Phe  Ser Pro Thr Asn Ser  Thr Ser Gln 
    2615                 2620                 2625             


Thr Val  Ser Ser Gly Ala Thr  Asn Gly Ala Glu Ser  Lys Thr Leu 
    2630                 2635                 2640             


Ile Tyr  Gln Met Ala Pro Ala  Val Ser Lys Thr Glu  Asp Val Trp 
    2645                 2650                 2655             


Val Arg  Ile Glu Asp Cys Pro  Ile Asn Asn Pro Arg  Ser Gly Arg 
    2660                 2665                 2670             


Ser Pro  Thr Gly Asn Thr Pro  Pro Val Ile Asp Ser  Val Ser Glu 
    2675                 2680                 2685             


Lys Ala  Asn Pro Asn Ile Lys  Asp Ser Lys Asp Asn  Gln Ala Lys 
    2690                 2695                 2700             


Gln Asn  Val Gly Asn Gly Ser  Val Pro Met Arg Thr  Val Gly Leu 
    2705                 2710                 2715             


Glu Asn  Arg Leu Asn Ser Phe  Ile Gln Val Asp Ala  Pro Asp Gln 
    2720                 2725                 2730             


Lys Gly  Thr Glu Ile Lys Pro  Gly Gln Asn Asn Pro  Val Pro Val 
    2735                 2740                 2745             


Ser Glu  Thr Asn Glu Ser Ser  Ile Val Glu Arg Thr  Pro Phe Ser 
    2750                 2755                 2760             


Ser Ser  Ser Ser Ser Lys His  Ser Ser Pro Ser Gly  Thr Val Ala 
    2765                 2770                 2775             


Ala Arg  Val Thr Pro Phe Asn  Tyr Asn Pro Ser Pro  Arg Lys Ser 
    2780                 2785                 2790             


Ser Ala  Asp Ser Thr Ser Ala  Arg Pro Ser Gln Ile  Pro Thr Pro 
    2795                 2800                 2805             


Val Asn  Asn Asn Thr Lys Lys  Arg Asp Ser Lys Thr  Asp Ser Thr 
    2810                 2815                 2820             


Glu Ser  Ser Gly Thr Gln Ser  Pro Lys Arg His Ser  Gly Ser Tyr 
    2825                 2830                 2835             


Leu Val  Thr Ser Val 
    2840             


<210>  5
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Asp Lys Leu Pro Tyr Lys Val Ala Asp Ile Gly Leu Ala Ala 
1               5                   10                  15      


Trp Gly Arg Lys Ala Leu Asp Ile Ala Glu Asn Glu Met Pro Gly Leu 
            20                  25                  30          


Met Arg Met Arg Glu Arg Tyr Ser Ala Ser Lys Pro Leu Lys Gly Ala 
        35                  40                  45              


Arg Ile Ala Gly Cys Leu His Met Thr Val Glu Thr Ala Val Leu Ile 
    50                  55                  60                  


Glu Thr Leu Val Thr Leu Gly Ala Glu Val Gln Trp Ser Ser Cys Asn 
65                  70                  75                  80  


Ile Phe Ser Thr Gln Asp His Ala Ala Ala Ala Ile Ala Lys Ala Gly 
                85                  90                  95      


Ile Pro Val Tyr Ala Trp Lys Gly Glu Thr Asp Glu Glu Tyr Leu Trp 
            100                 105                 110         


Cys Ile Glu Gln Thr Leu Tyr Phe Lys Asp Gly Pro Leu Asn Met Ile 
        115                 120                 125             


Leu Asp Asp Gly Gly Asp Leu Thr Asn Leu Ile His Thr Lys Tyr Pro 
    130                 135                 140                 


Gln Leu Leu Pro Gly Ile Arg Gly Ile Ser Glu Glu Thr Thr Thr Gly 
145                 150                 155                 160 


Val His Asn Leu Tyr Lys Met Met Ala Asn Gly Ile Leu Lys Val Pro 
                165                 170                 175     


Ala Ile Asn Val Asn Asp Ser Val Thr Lys Ser Lys Phe Asp Asn Leu 
            180                 185                 190         


Tyr Gly Cys Arg Glu Ser Leu Ile Asp Gly Ile Lys Arg Ala Thr Asp 
        195                 200                 205             


Val Met Ile Ala Gly Lys Val Ala Val Val Ala Gly Tyr Gly Asp Val 
    210                 215                 220                 


Gly Lys Gly Cys Ala Gln Ala Leu Arg Gly Phe Gly Ala Arg Val Ile 
225                 230                 235                 240 


Ile Thr Glu Ile Asp Pro Ile Asn Ala Leu Gln Ala Ala Met Glu Gly 
                245                 250                 255     


Tyr Glu Val Thr Thr Met Asp Glu Ala Cys Gln Glu Gly Asn Ile Phe 
            260                 265                 270         


Val Thr Thr Thr Gly Cys Ile Asp Ile Ile Leu Gly Arg His Phe Glu 
        275                 280                 285             


Gln Met Lys Asp Asp Ala Ile Val Cys Asn Ile Gly His Phe Asp Val 
    290                 295                 300                 


Glu Ile Asp Val Lys Trp Leu Asn Glu Asn Ala Val Glu Lys Val Asn 
305                 310                 315                 320 


Ile Lys Pro Gln Val Asp Arg Tyr Arg Leu Lys Asn Gly Arg Arg Ile 
                325                 330                 335     


Ile Leu Leu Ala Glu Gly Arg Leu Val Asn Leu Gly Cys Ala Met Gly 
            340                 345                 350         


His Pro Ser Phe Val Met Ser Asn Ser Phe Thr Asn Gln Val Met Ala 
        355                 360                 365             


Gln Ile Glu Leu Trp Thr His Pro Asp Lys Tyr Pro Val Gly Val His 
    370                 375                 380                 


Phe Leu Pro Lys Lys Leu Asp Glu Ala Val Ala Glu Ala His Leu Gly 
385                 390                 395                 400 


Lys Leu Asn Val Lys Leu Thr Lys Leu Thr Glu Lys Gln Ala Gln Tyr 
                405                 410                 415     


Leu Gly Met Ser Cys Asp Gly Pro Phe Lys Pro Asp His Tyr Arg Tyr 
            420                 425                 430         


<210>  6
<211>  5890
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Lys Glu Glu Thr Thr Arg Glu Leu Leu Leu Pro Asn Trp Gln 
1               5                   10                  15      


Gly Ser Gly Ser His Gly Leu Thr Ile Ala Gln Arg Asp Asp Gly Val 
            20                  25                  30          


Phe Val Gln Glu Val Thr Gln Asn Ser Pro Ala Ala Arg Thr Gly Val 
        35                  40                  45              


Val Lys Glu Gly Asp Gln Ile Val Gly Ala Thr Ile Tyr Phe Asp Asn 
    50                  55                  60                  


Leu Gln Ser Gly Glu Val Thr Gln Leu Leu Asn Thr Met Gly His His 
65                  70                  75                  80  


Thr Val Gly Leu Lys Leu His Arg Lys Gly Asp Arg Ser Pro Glu Pro 
                85                  90                  95      


Gly Gln Thr Trp Thr Arg Glu Val Phe Ser Ser Cys Ser Ser Glu Val 
            100                 105                 110         


Val Leu Ser Gly Asp Asp Glu Glu Tyr Gln Arg Ile Tyr Thr Thr Lys 
        115                 120                 125             


Ile Lys Pro Arg Leu Lys Ser Glu Asp Gly Val Glu Gly Asp Leu Gly 
    130                 135                 140                 


Glu Thr Gln Ser Arg Thr Ile Thr Val Thr Arg Arg Val Thr Ala Tyr 
145                 150                 155                 160 


Thr Val Asp Val Thr Gly Arg Glu Gly Ala Lys Asp Ile Asp Ile Ser 
                165                 170                 175     


Ser Pro Glu Phe Lys Ile Lys Ile Pro Arg His Glu Leu Thr Glu Ile 
            180                 185                 190         


Ser Asn Val Asp Val Glu Thr Gln Ser Gly Lys Thr Val Ile Arg Leu 
        195                 200                 205             


Pro Ser Gly Ser Gly Ala Ala Ser Pro Thr Gly Ser Ala Val Asp Ile 
    210                 215                 220                 


Arg Ala Gly Ala Ile Ser Ala Ser Gly Pro Glu Leu Gln Gly Ala Gly 
225                 230                 235                 240 


His Ser Lys Leu Gln Val Thr Met Pro Gly Ile Lys Val Gly Gly Ser 
                245                 250                 255     


Gly Val Asn Val Asn Ala Lys Gly Leu Asp Leu Gly Gly Arg Gly Gly 
            260                 265                 270         


Val Gln Val Pro Ala Val Asp Ile Ser Ser Ser Leu Gly Gly Arg Ala 
        275                 280                 285             


Val Glu Val Gln Gly Pro Ser Leu Glu Ser Gly Asp His Gly Lys Ile 
    290                 295                 300                 


Lys Phe Pro Thr Met Lys Val Pro Lys Phe Gly Val Ser Thr Gly Arg 
305                 310                 315                 320 


Glu Gly Gln Thr Pro Lys Ala Gly Leu Arg Val Ser Ala Pro Glu Val 
                325                 330                 335     


Ser Val Gly His Lys Gly Gly Lys Pro Gly Leu Thr Ile Gln Ala Pro 
            340                 345                 350         


Gln Leu Glu Val Ser Val Pro Ser Ala Asn Ile Glu Gly Leu Glu Gly 
        355                 360                 365             


Lys Leu Lys Gly Pro Gln Ile Thr Gly Pro Ser Leu Glu Gly Asp Leu 
    370                 375                 380                 


Gly Leu Lys Gly Ala Lys Pro Gln Gly His Ile Gly Val Asp Ala Ser 
385                 390                 395                 400 


Ala Pro Gln Ile Gly Gly Ser Ile Thr Gly Pro Ser Val Glu Val Gln 
                405                 410                 415     


Ala Pro Asp Ile Asp Val Gln Gly Pro Gly Ser Lys Leu Asn Val Pro 
            420                 425                 430         


Lys Met Lys Val Pro Lys Phe Ser Val Ser Gly Ala Lys Gly Glu Glu 
        435                 440                 445             


Thr Gly Ile Asp Val Thr Leu Pro Thr Gly Glu Val Thr Val Pro Gly 
    450                 455                 460                 


Val Ser Gly Asp Val Ser Leu Pro Glu Ile Ala Thr Gly Gly Leu Glu 
465                 470                 475                 480 


Gly Lys Met Lys Gly Thr Lys Val Lys Thr Pro Glu Met Ile Ile Gln 
                485                 490                 495     


Lys Pro Lys Ile Ser Met Gln Asp Val Asp Leu Ser Leu Gly Ser Pro 
            500                 505                 510         


Lys Leu Lys Gly Asp Ile Lys Val Ser Ala Pro Gly Val Gln Gly Asp 
        515                 520                 525             


Val Lys Gly Pro Gln Val Ala Leu Lys Gly Ser Arg Val Asp Ile Glu 
    530                 535                 540                 


Thr Pro Asn Leu Glu Gly Thr Leu Thr Gly Pro Arg Leu Gly Ser Pro 
545                 550                 555                 560 


Ser Gly Lys Thr Gly Thr Cys Arg Ile Ser Met Ser Glu Val Asp Leu 
                565                 570                 575     


Asn Val Ala Ala Pro Lys Val Lys Gly Gly Val Asp Val Thr Leu Pro 
            580                 585                 590         


Arg Val Glu Gly Lys Val Lys Val Pro Glu Val Asp Val Arg Gly Pro 
        595                 600                 605             


Lys Val Asp Val Ser Ala Pro Asp Val Glu Ala His Gly Pro Glu Trp 
    610                 615                 620                 


Asn Leu Lys Met Pro Lys Met Lys Met Pro Thr Phe Ser Thr Pro Gly 
625                 630                 635                 640 


Ala Lys Gly Glu Gly Pro Asp Val His Met Thr Leu Pro Lys Gly Asp 
                645                 650                 655     


Ile Ser Ile Ser Gly Pro Lys Val Asn Val Glu Ala Pro Asp Val Asn 
            660                 665                 670         


Leu Glu Gly Leu Gly Gly Lys Leu Lys Gly Pro Asp Val Lys Leu Pro 
        675                 680                 685             


Asp Met Ser Val Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu 
    690                 695                 700                 


His Val Lys Gly Thr Lys Val Lys Gly Glu Tyr Asp Val Thr Val Pro 
705                 710                 715                 720 


Lys Leu Glu Gly Glu Leu Lys Gly Pro Lys Val Asp Ile Asp Ala Pro 
                725                 730                 735     


Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro Lys Met 
            740                 745                 750         


Lys Met Pro Lys Phe Ser Val Pro Gly Phe Lys Ala Glu Gly Pro Glu 
        755                 760                 765             


Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys 
    770                 775                 780                 


Ile Asp Val Thr Ala Pro Asp Val Ser Ile Glu Glu Pro Glu Gly Lys 
785                 790                 795                 800 


Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Val Pro 
                805                 810                 815     


Lys Ile Ser Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Asn Val 
            820                 825                 830         


Lys Gly Glu Tyr Asp Val Thr Met Pro Lys Val Glu Ser Glu Ile Lys 
        835                 840                 845             


Val Pro Asp Val Glu Leu Lys Ser Ala Lys Met Asp Ile Asp Val Pro 
    850                 855                 860                 


Asp Val Glu Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Met 
865                 870                 875                 880 


Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Ala Glu Gly Pro Glu 
                885                 890                 895     


Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys 
            900                 905                 910         


Val Gly Val Glu Val Pro Asp Val Asn Ile Glu Gly Pro Glu Gly Lys 
        915                 920                 925             


Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro 
    930                 935                 940                 


Lys Ile Ser Met Pro Asp Val Asp Leu His Met Lys Gly Pro Lys Val 
945                 950                 955                 960 


Lys Gly Glu Tyr Asp Met Thr Val Pro Lys Leu Glu Gly Asp Leu Lys 
                965                 970                 975     


Gly Pro Lys Val Asp Val Ser Ala Pro Asp Val Glu Met Gln Gly Pro 
            980                 985                 990         


Asp Trp Asn Leu Lys Met Pro Lys  Ile Lys Met Pro Lys  Phe Ser Met 
        995                 1000                 1005             


Pro Ser  Leu Lys Gly Glu Gly  Pro Glu Phe Asp Val  Asn Leu Ser 
    1010                 1015                 1020             


Lys Ala  Asn Val Asp Ile Ser  Ala Pro Lys Val Asp  Thr Asn Ala 
    1025                 1030                 1035             


Pro Asp  Leu Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    1040                 1045                 1050             


Lys Phe  Lys Met Pro Glu Met  His Phe Arg Ala Pro  Lys Met Ser 
    1055                 1060                 1065             


Leu Pro  Asp Val Asp Leu Asp  Leu Lys Gly Pro Lys  Met Lys Gly 
    1070                 1075                 1080             


Asn Val  Asp Ile Ser Ala Pro  Lys Ile Glu Gly Glu  Met Gln Val 
    1085                 1090                 1095             


Pro Asp  Val Asp Ile Arg Gly  Pro Lys Val Asp Ile  Lys Ala Pro 
    1100                 1105                 1110             


Asp Val  Glu Gly Gln Gly Leu  Asp Trp Ser Leu Lys  Ile Pro Lys 
    1115                 1120                 1125             


Met Lys  Met Pro Lys Phe Ser  Met Pro Ser Leu Lys  Gly Glu Gly 
    1130                 1135                 1140             


Pro Glu  Val Asp Val Asn Leu  Pro Lys Ala Asp Val  Val Val Ser 
    1145                 1150                 1155             


Gly Pro  Lys Val Asp Ile Glu  Ala Pro Asp Val Ser  Leu Glu Gly 
    1160                 1165                 1170             


Pro Glu  Gly Lys Leu Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met 
    1175                 1180                 1185             


His Phe  Lys Thr Pro Lys Ile  Ser Met Pro Asp Val  Asp Leu His 
    1190                 1195                 1200             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Val Asp Val  Ser Val Pro 
    1205                 1210                 1215             


Lys Val  Glu Gly Glu Met Lys  Val Pro Asp Val Glu  Ile Lys Gly 
    1220                 1225                 1230             


Pro Lys  Met Asp Ile Asp Ala  Pro Asp Val Glu Val  Gln Gly Pro 
    1235                 1240                 1245             


Asp Trp  His Leu Lys Met Pro  Lys Met Lys Met Pro  Lys Phe Ser 
    1250                 1255                 1260             


Met Pro  Gly Phe Lys Gly Glu  Gly Arg Glu Val Asp  Val Asn Leu 
    1265                 1270                 1275             


Pro Lys  Ala Asp Ile Asp Val  Ser Gly Pro Lys Val  Asp Val Glu 
    1280                 1285                 1290             


Val Pro  Asp Val Ser Leu Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    1295                 1300                 1305             


Pro Lys  Phe Lys Met Pro Glu  Met His Phe Lys Ala  Pro Lys Ile 
    1310                 1315                 1320             


Ser Met  Pro Asp Val Asp Leu  Asn Leu Lys Gly Pro  Lys Leu Lys 
    1325                 1330                 1335             


Gly Asp  Val Asp Val Ser Leu  Pro Glu Val Glu Gly  Glu Met Lys 
    1340                 1345                 1350             


Val Pro  Asp Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Ser Ala 
    1355                 1360                 1365             


Pro Asp  Val Asp Val His Gly  Pro Asp Trp His Leu  Lys Met Pro 
    1370                 1375                 1380             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    1385                 1390                 1395             


Gly Pro  Glu Val Asp Val Lys  Leu Pro Lys Ala Asp  Val Asp Val 
    1400                 1405                 1410             


Ser Gly  Pro Lys Met Asp Ala  Glu Val Pro Asp Val  Asn Ile Glu 
    1415                 1420                 1425             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    1430                 1435                 1440             


Met Ser  Ile Lys Pro Gln Lys  Ile Ser Ile Pro Asp  Val Gly Leu 
    1445                 1450                 1455             


His Leu  Lys Gly Pro Lys Met  Lys Gly Asp Tyr Asp  Val Thr Val 
    1460                 1465                 1470             


Pro Lys  Val Glu Gly Glu Ile  Lys Ala Pro Asp Val  Asp Ile Lys 
    1475                 1480                 1485             


Gly Pro  Lys Val Asp Ile Asn  Ala Pro Asp Val Glu  Val His Gly 
    1490                 1495                 1500             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    1505                 1510                 1515             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Glu Val  Asp Met Asn 
    1520                 1525                 1530             


Leu Pro  Lys Ala Asp Leu Gly  Val Ser Gly Pro Lys  Val Asp Ile 
    1535                 1540                 1545             


Asp Val  Pro Asp Val Asn Leu  Glu Ala Pro Glu Gly  Lys Leu Lys 
    1550                 1555                 1560             


Gly Pro  Lys Phe Lys Met Pro  Ser Met Asn Ile Gln  Thr His Lys 
    1565                 1570                 1575             


Ile Ser  Met Pro Asp Val Gly  Leu Asn Leu Lys Ala  Pro Lys Leu 
    1580                 1585                 1590             


Lys Thr  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu 
    1595                 1600                 1605             


Lys Gly  Pro Glu Ile Asp Val  Lys Ala Pro Lys Met  Asp Val Asn 
    1610                 1615                 1620             


Val Gly  Asp Ile Asp Ile Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    1625                 1630                 1635             


Pro Lys  Phe Lys Met Pro Glu  Met His Phe Lys Ala  Pro Lys Ile 
    1640                 1645                 1650             


Ser Met  Pro Asp Val Asp Leu  His Leu Lys Gly Pro  Lys Val Lys 
    1655                 1660                 1665             


Gly Asp  Met Asp Val Ser Val  Pro Lys Val Glu Gly  Glu Met Lys 
    1670                 1675                 1680             


Val Pro  Asp Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asp Ala 
    1685                 1690                 1695             


Pro Asp  Val Glu Val His Asp  Pro Asp Trp His Leu  Lys Met Pro 
    1700                 1705                 1710             


Lys Met  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Ala Glu 
    1715                 1720                 1725             


Gly Pro  Glu Val Asp Val Asn  Leu Pro Lys Ala Asp  Ile Asp Val 
    1730                 1735                 1740             


Ser Gly  Pro Ser Val Asp Thr  Asp Ala Pro Asp Leu  Asp Ile Glu 
    1745                 1750                 1755             


Gly Pro  Glu Gly Lys Leu Lys  Gly Ser Lys Phe Lys  Met Pro Lys 
    1760                 1765                 1770             


Leu Asn  Ile Lys Ala Pro Lys  Val Ser Met Pro Asp  Val Asp Leu 
    1775                 1780                 1785             


Asn Leu  Lys Gly Pro Lys Leu  Lys Gly Glu Ile Asp  Ala Ser Val 
    1790                 1795                 1800             


Pro Glu  Leu Glu Gly Asp Leu  Arg Gly Pro Gln Val  Asp Val Lys 
    1805                 1810                 1815             


Gly Pro  Phe Val Glu Ala Glu  Val Pro Asp Val Asp  Leu Glu Cys 
    1820                 1825                 1830             


Pro Asp  Ala Lys Leu Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met 
    1835                 1840                 1845             


His Phe  Lys Ala Pro Lys Ile  Ser Met Pro Asp Val  Asp Leu His 
    1850                 1855                 1860             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Ala Asp Val  Ser Val Pro 
    1865                 1870                 1875             


Lys Leu  Glu Gly Asp Leu Thr  Gly Pro Ser Val Gly  Val Glu Val 
    1880                 1885                 1890             


Pro Asp  Val Glu Leu Glu Cys  Pro Asp Ala Lys Leu  Lys Gly Pro 
    1895                 1900                 1905             


Lys Phe  Lys Met Pro Asp Met  His Phe Lys Ala Pro  Lys Ile Ser 
    1910                 1915                 1920             


Met Pro  Asp Val Asp Leu His  Leu Lys Gly Pro Lys  Val Lys Gly 
    1925                 1930                 1935             


Asp Val  Asp Val Ser Val Pro  Lys Leu Glu Gly Asp  Leu Thr Gly 
    1940                 1945                 1950             


Pro Ser  Val Gly Val Glu Val  Pro Asp Val Glu Leu  Glu Cys Pro 
    1955                 1960                 1965             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met His 
    1970                 1975                 1980             


Phe Lys  Thr Pro Lys Ile Ser  Met Pro Asp Val Asp  Leu His Leu 
    1985                 1990                 1995             


Lys Gly  Pro Lys Val Lys Gly  Asp Met Asp Val Ser  Val Pro Lys 
    2000                 2005                 2010             


Val Glu  Gly Glu Met Lys Val  Pro Asp Val Asp Ile  Lys Gly Pro 
    2015                 2020                 2025             


Lys Met  Asp Ile Asp Ala Pro  Asp Val Asp Val His  Gly Pro Asp 
    2030                 2035                 2040             


Trp His  Leu Lys Met Pro Lys  Met Lys Met Pro Lys  Phe Ser Met 
    2045                 2050                 2055             


Pro Gly  Phe Lys Ala Glu Gly  Pro Glu Val Asp Val  Asn Leu Pro 
    2060                 2065                 2070             


Lys Ala  Asp Val Val Val Ser  Gly Pro Lys Val Asp  Val Glu Val 
    2075                 2080                 2085             


Pro Asp  Val Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    2090                 2095                 2100             


Lys Leu  Lys Met Pro Glu Met  His Phe Lys Ala Pro  Lys Ile Ser 
    2105                 2110                 2115             


Met Pro  Asp Val Asp Leu His  Leu Lys Gly Pro Lys  Val Lys Gly 
    2120                 2125                 2130             


Asp Val  Asp Val Ser Leu Pro  Lys Leu Glu Gly Asp  Leu Thr Gly 
    2135                 2140                 2145             


Pro Ser  Val Asp Val Glu Val  Pro Asp Val Glu Leu  Glu Cys Pro 
    2150                 2155                 2160             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met His 
    2165                 2170                 2175             


Phe Lys  Thr Pro Lys Ile Ser  Met Pro Asp Val Asn  Leu Asn Leu 
    2180                 2185                 2190             


Lys Gly  Pro Lys Val Lys Gly  Asp Met Asp Val Ser  Val Pro Lys 
    2195                 2200                 2205             


Val Glu  Gly Glu Met Lys Val  Pro Asp Val Asp Ile  Arg Gly Pro 
    2210                 2215                 2220             


Lys Val  Asp Ile Asp Ala Pro  Asp Val Asp Val His  Gly Pro Asp 
    2225                 2230                 2235             


Trp His  Leu Lys Met Pro Lys  Met Lys Met Pro Lys  Phe Ser Met 
    2240                 2245                 2250             


Pro Gly  Phe Lys Gly Glu Gly  Pro Glu Val Asp Val  Asn Leu Pro 
    2255                 2260                 2265             


Lys Ala  Asp Val Asp Val Ser  Gly Pro Lys Val Asp  Val Glu Val 
    2270                 2275                 2280             


Pro Asp  Val Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    2285                 2290                 2295             


Lys Phe  Lys Met Pro Glu Met  His Phe Lys Thr Pro  Lys Ile Ser 
    2300                 2305                 2310             


Met Pro  Asp Val Asp Phe Asn  Leu Lys Gly Pro Lys  Ile Lys Gly 
    2315                 2320                 2325             


Asp Val  Asp Val Ser Ala Pro  Lys Leu Glu Gly Glu  Leu Lys Gly 
    2330                 2335                 2340             


Pro Glu  Leu Asp Val Lys Gly  Pro Lys Leu Asp Ala  Asp Met Pro 
    2345                 2350                 2355             


Glu Val  Ala Val Glu Gly Pro  Asn Gly Lys Trp Lys  Thr Pro Lys 
    2360                 2365                 2370             


Phe Lys  Met Pro Asp Met His  Phe Lys Ala Pro Lys  Ile Ser Met 
    2375                 2380                 2385             


Pro Asp  Leu Asp Leu His Leu  Lys Ser Pro Lys Ala  Lys Gly Glu 
    2390                 2395                 2400             


Val Asp  Val Asp Val Pro Lys  Leu Glu Gly Asp Leu  Lys Gly Pro 
    2405                 2410                 2415             


His Val  Asp Val Ser Gly Pro  Asp Ile Asp Ile Glu  Gly Pro Glu 
    2420                 2425                 2430             


Gly Lys  Leu Lys Gly Pro Lys  Phe Lys Met Pro Asp  Met His Phe 
    2435                 2440                 2445             


Lys Ala  Pro Asn Ile Ser Met  Pro Asp Val Asp Leu  Asn Leu Lys 
    2450                 2455                 2460             


Gly Pro  Lys Ile Lys Gly Asp  Val Asp Val Ser Val  Pro Glu Val 
    2465                 2470                 2475             


Glu Gly  Lys Leu Glu Val Pro  Asp Met Asn Ile Arg  Gly Pro Lys 
    2480                 2485                 2490             


Val Asp  Val Asn Ala Pro Asp  Val Gln Ala Pro Asp  Trp His Leu 
    2495                 2500                 2505             


Lys Met  Pro Lys Met Lys Met  Pro Lys Phe Ser Met  Pro Gly Phe 
    2510                 2515                 2520             


Lys Ala  Glu Gly Pro Glu Val  Asp Val Asn Leu Pro  Lys Ala Asp 
    2525                 2530                 2535             


Val Asp  Ile Ser Gly Pro Lys  Val Asp Ile Glu Gly  Pro Asp Val 
    2540                 2545                 2550             


Asn Ile  Glu Gly Pro Glu Gly  Lys Leu Lys Gly Pro  Lys Leu Lys 
    2555                 2560                 2565             


Met Pro  Glu Met Asn Ile Lys  Ala Pro Lys Ile Ser  Met Pro Asp 
    2570                 2575                 2580             


Phe Asp  Leu His Leu Lys Gly  Pro Lys Val Lys Gly  Asp Val Asp 
    2585                 2590                 2595             


Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu Lys Gly  Pro Glu Val 
    2600                 2605                 2610             


Asp Ile  Lys Gly Pro Lys Val  Asp Ile Asn Ala Pro  Asp Val Gly 
    2615                 2620                 2625             


Val Gln  Gly Pro Asp Trp His  Leu Lys Met Pro Lys  Val Lys Met 
    2630                 2635                 2640             


Pro Lys  Phe Ser Met Pro Gly  Phe Lys Gly Glu Gly  Pro Asp Gly 
    2645                 2650                 2655             


Asp Val  Lys Leu Pro Lys Ala  Asp Ile Asp Val Ser  Gly Pro Lys 
    2660                 2665                 2670             


Val Asp  Ile Glu Gly Pro Asp  Val Asn Ile Glu Gly  Pro Glu Gly 
    2675                 2680                 2685             


Lys Leu  Lys Gly Pro Lys Phe  Lys Met Pro Glu Met  Asn Ile Lys 
    2690                 2695                 2700             


Ala Pro  Lys Ile Ser Met Pro  Asp Ile Asp Leu Asn  Leu Lys Gly 
    2705                 2710                 2715             


Pro Lys  Val Lys Gly Asp Val  Asp Val Ser Leu Pro  Lys Val Glu 
    2720                 2725                 2730             


Gly Asp  Leu Lys Gly Pro Glu  Val Asp Ile Lys Gly  Pro Lys Val 
    2735                 2740                 2745             


Asp Ile  Asp Ala Pro Asp Val  Asp Val His Gly Pro  Asp Trp His 
    2750                 2755                 2760             


Leu Lys  Met Pro Lys Ile Lys  Met Pro Lys Ile Ser  Met Pro Gly 
    2765                 2770                 2775             


Phe Lys  Gly Glu Gly Pro Asp  Val Asp Val Asn Leu  Pro Lys Ala 
    2780                 2785                 2790             


Asp Ile  Asp Val Ser Gly Pro  Lys Val Asp Val Glu  Cys Pro Asp 
    2795                 2800                 2805             


Val Asn  Ile Glu Gly Pro Glu  Gly Lys Trp Lys Ser  Pro Lys Phe 
    2810                 2815                 2820             


Lys Met  Pro Glu Met His Phe  Lys Thr Pro Lys Ile  Ser Met Pro 
    2825                 2830                 2835             


Asp Ile  Asp Leu Asn Leu Thr  Gly Pro Lys Ile Lys  Gly Asp Val 
    2840                 2845                 2850             


Asp Val  Thr Gly Pro Lys Val  Glu Gly Asp Leu Lys  Gly Pro Glu 
    2855                 2860                 2865             


Val Asp  Leu Lys Gly Pro Lys  Val Asp Ile Asp Val  Pro Asp Val 
    2870                 2875                 2880             


Asn Val  Gln Gly Pro Asp Trp  His Leu Lys Met Pro  Lys Met Lys 
    2885                 2890                 2895             


Met Pro  Lys Phe Ser Met Pro  Gly Phe Lys Ala Glu  Gly Pro Glu 
    2900                 2905                 2910             


Val Asp  Val Asn Leu Pro Lys  Ala Asp Val Asp Val  Ser Gly Pro 
    2915                 2920                 2925             


Lys Val  Asp Val Glu Gly Pro  Asp Val Asn Ile Glu  Gly Pro Glu 
    2930                 2935                 2940             


Gly Lys  Leu Lys Gly Pro Lys  Phe Lys Met Pro Glu  Met Asn Ile 
    2945                 2950                 2955             


Lys Ala  Pro Lys Ile Pro Met  Pro Asp Phe Asp Leu  His Leu Lys 
    2960                 2965                 2970             


Gly Pro  Lys Val Lys Gly Asp  Val Asp Ile Ser Leu  Pro Lys Val 
    2975                 2980                 2985             


Glu Gly  Asp Leu Lys Gly Pro  Glu Val Asp Ile Arg  Gly Pro Gln 
    2990                 2995                 3000             


Val Asp  Ile Asp Val Pro Asp  Val Gly Val Gln Gly  Pro Asp Trp 
    3005                 3010                 3015             


His Leu  Lys Met Pro Lys Val  Lys Met Pro Lys Phe  Ser Met Pro 
    3020                 3025                 3030             


Gly Phe  Lys Gly Glu Gly Pro  Asp Val Asp Val Asn  Leu Pro Lys 
    3035                 3040                 3045             


Ala Asp  Leu Asp Val Ser Gly  Pro Lys Val Asp Ile  Asp Val Pro 
    3050                 3055                 3060             


Asp Val  Asn Ile Glu Gly Pro  Glu Gly Lys Leu Lys  Gly Pro Lys 
    3065                 3070                 3075             


Phe Lys  Met Pro Glu Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met 
    3080                 3085                 3090             


Pro Asp  Ile Asp Leu Asn Leu  Lys Gly Pro Lys Val  Lys Gly Asp 
    3095                 3100                 3105             


Met Asp  Val Ser Leu Pro Lys  Val Glu Gly Asp Met  Lys Val Pro 
    3110                 3115                 3120             


Asp Val  Asp Ile Lys Gly Pro  Lys Val Asp Ile Asn  Ala Pro Asp 
    3125                 3130                 3135             


Val Asp  Val Gln Gly Pro Asp  Trp His Leu Lys Met  Pro Lys Ile 
    3140                 3145                 3150             


Lys Met  Pro Lys Ile Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro 
    3155                 3160                 3165             


Glu Val  Asp Val Asn Leu Pro  Lys Ala Asp Leu Asp  Val Ser Gly 
    3170                 3175                 3180             


Pro Lys  Val Asp Val Asp Val  Pro Asp Val Asn Ile  Glu Gly Pro 
    3185                 3190                 3195             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met Asn 
    3200                 3205                 3210             


Ile Lys  Ala Pro Lys Ile Ser  Met Pro Asp Leu Asp  Leu Asn Leu 
    3215                 3220                 3225             


Lys Gly  Pro Lys Met Lys Gly  Glu Val Asp Val Ser  Leu Ala Asn 
    3230                 3235                 3240             


Val Glu  Gly Asp Leu Lys Gly  Pro Ala Leu Asp Ile  Lys Gly Pro 
    3245                 3250                 3255             


Lys Ile  Asp Val Asp Ala Pro  Asp Ile Asp Ile His  Gly Pro Asp 
    3260                 3265                 3270             


Ala Lys  Leu Lys Gly Pro Lys  Leu Lys Met Pro Asp  Met His Val 
    3275                 3280                 3285             


Asn Met  Pro Lys Ile Ser Met  Pro Glu Ile Asp Leu  Asn Leu Lys 
    3290                 3295                 3300             


Gly Ser  Lys Leu Lys Gly Asp  Val Asp Val Ser Gly  Pro Lys Leu 
    3305                 3310                 3315             


Glu Gly  Asp Ile Lys Ala Pro  Ser Leu Asp Ile Lys  Gly Pro Glu 
    3320                 3325                 3330             


Val Asp  Val Ser Gly Pro Lys  Leu Asn Ile Glu Gly  Lys Ser Lys 
    3335                 3340                 3345             


Lys Ser  Arg Phe Lys Leu Pro  Lys Phe Asn Phe Ser  Gly Ser Lys 
    3350                 3355                 3360             


Val Gln  Thr Pro Glu Val Asp  Val Lys Gly Lys Lys  Pro Asp Ile 
    3365                 3370                 3375             


Asp Ile  Thr Gly Pro Lys Val  Asp Ile Asn Ala Pro  Asp Val Glu 
    3380                 3385                 3390             


Val Gln  Gly Lys Val Lys Gly  Ser Lys Phe Lys Met  Pro Phe Leu 
    3395                 3400                 3405             


Ser Ile  Ser Ser Pro Lys Val  Ser Met Pro Asp Val  Glu Leu Asn 
    3410                 3415                 3420             


Leu Lys  Ser Pro Lys Val Lys  Gly Asp Leu Asp Ile  Ala Gly Pro 
    3425                 3430                 3435             


Asn Leu  Glu Gly Asp Phe Lys  Gly Pro Lys Val Asp  Ile Lys Ala 
    3440                 3445                 3450             


Pro Glu  Val Asn Leu Asn Ala  Pro Asp Val Asp Val  His Gly Pro 
    3455                 3460                 3465             


Asp Trp  Asn Leu Lys Met Pro  Lys Met Lys Met Pro  Lys Phe Ser 
    3470                 3475                 3480             


Val Ser  Gly Leu Lys Ala Glu  Gly Pro Asp Val Ala  Val Asp Leu 
    3485                 3490                 3495             


Pro Lys  Gly Asp Ile Asn Ile  Glu Gly Pro Ser Met  Asn Ile Glu 
    3500                 3505                 3510             


Gly Pro  Asp Leu Asn Val Glu  Gly Pro Glu Gly Gly  Leu Lys Gly 
    3515                 3520                 3525             


Pro Lys  Phe Lys Met Pro Asp  Met Asn Ile Lys Ala  Pro Lys Ile 
    3530                 3535                 3540             


Ser Met  Pro Asp Ile Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    3545                 3550                 3555             


Gly Asp  Val Asp Ile Ser Leu  Pro Lys Leu Glu Gly  Asp Leu Lys 
    3560                 3565                 3570             


Gly Pro  Glu Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asn Ala 
    3575                 3580                 3585             


Pro Asp  Val Asp Val His Gly  Pro Asp Trp His Leu  Lys Met Pro 
    3590                 3595                 3600             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    3605                 3610                 3615             


Gly Pro  Glu Val Asp Val Thr  Leu Pro Lys Ala Asp  Ile Asp Ile 
    3620                 3625                 3630             


Ser Gly  Pro Asn Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    3635                 3640                 3645             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    3650                 3655                 3660             


Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Phe Asp Leu 
    3665                 3670                 3675             


Asn Leu  Lys Gly Pro Lys Met  Lys Gly Asp Val Val  Val Ser Leu 
    3680                 3685                 3690             


Pro Lys  Val Glu Gly Asp Leu  Lys Gly Pro Glu Val  Asp Ile Lys 
    3695                 3700                 3705             


Gly Pro  Lys Val Asp Ile Asp  Thr Pro Asp Ile Asn  Ile Glu Gly 
    3710                 3715                 3720             


Ser Glu  Gly Lys Phe Lys Gly  Pro Lys Phe Lys Ile  Pro Glu Met 
    3725                 3730                 3735             


His Leu  Lys Ala Pro Lys Ile  Ser Met Pro Asp Ile  Asp Leu Asn 
    3740                 3745                 3750             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Val Asp Val  Ser Leu Pro 
    3755                 3760                 3765             


Lys Met  Glu Gly Asp Leu Lys  Gly Pro Glu Val Asp  Ile Lys Gly 
    3770                 3775                 3780             


Pro Lys  Val Asp Ile Asn Ala  Pro Asp Val Asp Val  Gln Gly Pro 
    3785                 3790                 3795             


Asp Trp  His Leu Lys Met Pro  Lys Val Lys Met Pro  Lys Phe Ser 
    3800                 3805                 3810             


Met Pro  Gly Phe Lys Gly Glu  Gly Pro Asp Val Asp  Val Asn Leu 
    3815                 3820                 3825             


Pro Lys  Ala Asp Leu Asp Val  Ser Gly Pro Lys Val  Asp Ile Asp 
    3830                 3835                 3840             


Val Pro  Asp Val Asn Ile Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    3845                 3850                 3855             


Pro Lys  Phe Lys Met Pro Glu  Met Asn Ile Lys Ala  Pro Lys Ile 
    3860                 3865                 3870             


Ser Met  Pro Asp Ile Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    3875                 3880                 3885             


Gly Asp  Met Asp Val Ser Leu  Pro Lys Val Glu Gly  Asp Met Gln 
    3890                 3895                 3900             


Val Pro  Asp Leu Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asn Ala 
    3905                 3910                 3915             


Pro Asp  Val Asp Val Arg Gly  Pro Asp Trp His Leu  Lys Met Pro 
    3920                 3925                 3930             


Lys Ile  Lys Met Pro Lys Ile  Ser Met Pro Gly Phe  Lys Gly Glu 
    3935                 3940                 3945             


Gly Pro  Glu Val Asp Val Asn  Leu Pro Lys Ala Asp  Leu Asp Val 
    3950                 3955                 3960             


Ser Gly  Pro Lys Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    3965                 3970                 3975             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    3980                 3985                 3990             


Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Phe Asp Leu 
    3995                 4000                 4005             


His Leu  Lys Gly Pro Lys Val  Lys Gly Asp Val Asp  Val Ser Leu 
    4010                 4015                 4020             


Pro Lys  Met Glu Gly Asp Leu  Lys Ala Pro Glu Val  Asp Ile Lys 
    4025                 4030                 4035             


Gly Pro  Lys Val Asp Ile Asp  Ala Pro Asp Val Asp  Val His Gly 
    4040                 4045                 4050             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    4055                 4060                 4065             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Glu Val  Asp Val Asn 
    4070                 4075                 4080             


Leu Pro  Lys Ala Asp Ile Asp  Val Ser Gly Pro Lys  Val Asp Ile 
    4085                 4090                 4095             


Asp Thr  Pro Asp Ile Asp Ile  His Gly Pro Glu Gly  Lys Leu Lys 
    4100                 4105                 4110             


Gly Pro  Lys Phe Lys Met Pro  Asp Leu His Leu Lys  Ala Pro Lys 
    4115                 4120                 4125             


Ile Ser  Met Pro Glu Val Asp  Leu Asn Leu Lys Gly  Pro Lys Met 
    4130                 4135                 4140             


Lys Gly  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu 
    4145                 4150                 4155             


Lys Gly  Pro Glu Val Asp Ile  Lys Gly Pro Lys Val  Asp Ile Asp 
    4160                 4165                 4170             


Val Pro  Asp Val Asp Val Gln  Gly Pro Asp Trp His  Leu Lys Met 
    4175                 4180                 4185             


Pro Lys  Val Lys Met Pro Lys  Phe Ser Met Pro Gly  Phe Lys Gly 
    4190                 4195                 4200             


Glu Gly  Pro Asp Val Asp Val  Asn Leu Pro Lys Ala  Asp Leu Asp 
    4205                 4210                 4215             


Val Ser  Gly Pro Lys Val Asp  Ile Asp Val Pro Asp  Val Asn Ile 
    4220                 4225                 4230             


Glu Gly  Pro Asp Ala Lys Leu  Lys Gly Pro Lys Phe  Lys Met Pro 
    4235                 4240                 4245             


Glu Met  Asn Ile Lys Ala Pro  Lys Ile Ser Met Pro  Asp Phe Asp 
    4250                 4255                 4260             


Leu His  Leu Lys Gly Pro Lys  Val Lys Gly Asp Val  Asp Val Ser 
    4265                 4270                 4275             


Leu Pro  Lys Val Glu Gly Asp  Leu Lys Gly Pro Glu  Val Asp Ile 
    4280                 4285                 4290             


Lys Gly  Pro Lys Val Asp Ile  Asp Ala Pro Asp Val  Asp Val His 
    4295                 4300                 4305             


Gly Pro  Asp Trp His Leu Lys  Met Pro Lys Val Lys  Met Pro Lys 
    4310                 4315                 4320             


Phe Ser  Met Pro Gly Phe Lys  Gly Glu Gly Pro Asp  Val Asp Val 
    4325                 4330                 4335             


Thr Leu  Pro Lys Ala Asp Ile  Glu Ile Ser Gly Pro  Lys Val Asp 
    4340                 4345                 4350             


Ile Asp  Ala Pro Asp Val Ser  Ile Glu Gly Pro Asp  Ala Lys Leu 
    4355                 4360                 4365             


Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met Asn Ile  Lys Ala Pro 
    4370                 4375                 4380             


Lys Ile  Ser Met Pro Asp Ile  Asp Phe Asn Leu Lys  Gly Pro Lys 
    4385                 4390                 4395             


Val Lys  Gly Asp Val Asp Val  Ser Leu Pro Lys Val  Glu Gly Asp 
    4400                 4405                 4410             


Leu Lys  Gly Pro Glu Ile Asp  Ile Lys Gly Pro Ser  Leu Asp Ile 
    4415                 4420                 4425             


Asp Thr  Pro Asp Val Asn Ile  Glu Gly Pro Glu Gly  Lys Leu Lys 
    4430                 4435                 4440             


Gly Pro  Lys Phe Lys Met Pro  Glu Met Asn Ile Lys  Ala Pro Lys 
    4445                 4450                 4455             


Ile Ser  Met Pro Asp Phe Asp  Leu His Leu Lys Gly  Pro Lys Val 
    4460                 4465                 4470             


Lys Gly  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Ser Asp Leu 
    4475                 4480                 4485             


Lys Gly  Pro Glu Val Asp Ile  Glu Gly Pro Glu Gly  Lys Leu Lys 
    4490                 4495                 4500             


Gly Pro  Lys Phe Lys Met Pro  Asp Val His Phe Lys  Ser Pro Gln 
    4505                 4510                 4515             


Ile Ser  Met Ser Asp Ile Asp  Leu Asn Leu Lys Gly  Pro Lys Ile 
    4520                 4525                 4530             


Lys Gly  Asp Met Asp Ile Ser  Val Pro Lys Leu Glu  Gly Asp Leu 
    4535                 4540                 4545             


Lys Gly  Pro Lys Val Asp Val  Lys Gly Pro Lys Val  Gly Ile Asp 
    4550                 4555                 4560             


Thr Pro  Asp Ile Asp Ile His  Gly Pro Glu Gly Lys  Leu Lys Gly 
    4565                 4570                 4575             


Pro Lys  Phe Lys Met Pro Asp  Leu His Leu Lys Ala  Pro Lys Ile 
    4580                 4585                 4590             


Ser Met  Pro Glu Val Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    4595                 4600                 4605             


Gly Asp  Met Asp Ile Ser Leu  Pro Lys Val Glu Gly  Asp Leu Lys 
    4610                 4615                 4620             


Gly Pro  Glu Val Asp Ile Arg  Asp Pro Lys Val Asp  Ile Asp Val 
    4625                 4630                 4635             


Pro Asp  Val Asp Val Gln Gly  Pro Asp Trp His Leu  Lys Met Pro 
    4640                 4645                 4650             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    4655                 4660                 4665             


Gly Pro  Asp Val Asp Val Asn  Leu Pro Lys Ala Asp  Ile Asp Val 
    4670                 4675                 4680             


Ser Gly  Pro Lys Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    4685                 4690                 4695             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    4700                 4705                 4710             


Met Ser  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Ile Asp Leu 
    4715                 4720                 4725             


Asn Leu  Lys Gly Pro Lys Val  Lys Gly Asp Val Asp  Val Thr Leu 
    4730                 4735                 4740             


Pro Lys  Val Glu Gly Asp Leu  Lys Gly Pro Glu Ala  Asp Ile Lys 
    4745                 4750                 4755             


Gly Pro  Lys Val Asp Ile Asn  Thr Pro Asp Val Asp  Val His Gly 
    4760                 4765                 4770             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    4775                 4780                 4785             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Asp Val  Asp Val Ser 
    4790                 4795                 4800             


Leu Pro  Lys Ala Asp Ile Asp  Val Ser Gly Pro Lys  Val Asp Val 
    4805                 4810                 4815             


Asp Ile  Pro Asp Val Asn Ile  Glu Gly Pro Asp Ala  Lys Leu Lys 
    4820                 4825                 4830             


Gly Pro  Lys Phe Lys Met Pro  Glu Ile Asn Ile Lys  Ala Pro Lys 
    4835                 4840                 4845             


Ile Ser  Ile Pro Asp Val Asp  Leu Asp Leu Lys Gly  Pro Lys Val 
    4850                 4855                 4860             


Lys Gly  Asp Phe Asp Val Ser  Val Pro Lys Val Glu  Gly Thr Leu 
    4865                 4870                 4875             


Lys Gly  Pro Glu Val Asp Leu  Lys Gly Pro Arg Leu  Asp Phe Glu 
    4880                 4885                 4890             


Gly Pro  Asp Ala Lys Leu Ser  Gly Pro Ser Leu Lys  Met Pro Ser 
    4895                 4900                 4905             


Leu Glu  Ile Ser Ala Pro Lys  Val Thr Ala Pro Asp  Val Asp Leu 
    4910                 4915                 4920             


His Leu  Lys Ala Pro Lys Ile  Gly Phe Ser Gly Pro  Lys Leu Glu 
    4925                 4930                 4935             


Gly Gly  Glu Val Asp Leu Lys  Gly Pro Lys Val Glu  Ala Pro Ser 
    4940                 4945                 4950             


Leu Asp  Val His Met Asp Ser  Pro Asp Ile Asn Ile  Glu Gly Pro 
    4955                 4960                 4965             


Asp Val  Lys Ile Pro Lys Phe  Lys Lys Pro Lys Phe  Gly Phe Gly 
    4970                 4975                 4980             


Ala Lys  Ser Pro Lys Ala Asp  Ile Lys Ser Pro Ser  Leu Asp Val 
    4985                 4990                 4995             


Thr Val  Pro Glu Ala Glu Leu  Asn Leu Glu Thr Pro  Glu Ile Ser 
    5000                 5005                 5010             


Val Gly  Gly Lys Gly Lys Lys  Ser Lys Phe Lys Met  Pro Lys Ile 
    5015                 5020                 5025             


His Met  Ser Gly Pro Lys Ile  Lys Ala Lys Lys Gln  Gly Phe Asp 
    5030                 5035                 5040             


Leu Asn  Val Pro Gly Gly Glu  Ile Asp Ala Ser Leu  Lys Ala Pro 
    5045                 5050                 5055             


Asp Val  Asp Val Asn Ile Ala  Gly Pro Asp Ala Ala  Leu Lys Val 
    5060                 5065                 5070             


Asp Val  Lys Ser Pro Lys Thr  Lys Lys Thr Met Phe  Gly Lys Met 
    5075                 5080                 5085             


Tyr Phe  Pro Asp Val Glu Phe  Asp Ile Lys Ser Pro  Lys Phe Lys 
    5090                 5095                 5100             


Ala Glu  Ala Pro Leu Pro Ser  Pro Lys Leu Glu Gly  Glu Leu Gln 
    5105                 5110                 5115             


Ala Pro  Asp Leu Glu Leu Ser  Leu Pro Ala Ile His  Val Glu Gly 
    5120                 5125                 5130             


Leu Asp  Ile Lys Ala Lys Ala  Pro Lys Val Lys Met  Pro Asp Val 
    5135                 5140                 5145             


Asp Ile  Ser Val Pro Lys Ile  Glu Gly Asp Leu Lys  Gly Pro Lys 
    5150                 5155                 5160             


Val Gln  Ala Asn Leu Gly Ala  Pro Asp Ile Asn Ile  Glu Gly Leu 
    5165                 5170                 5175             


Asp Ala  Lys Val Lys Thr Pro  Ser Phe Gly Ile Ser  Ala Pro Gln 
    5180                 5185                 5190             


Val Ser  Ile Pro Asp Val Asn  Val Asn Leu Lys Gly  Pro Lys Ile 
    5195                 5200                 5205             


Lys Gly  Asp Val Pro Ser Val  Gly Leu Glu Gly Pro  Asp Val Asp 
    5210                 5215                 5220             


Leu Gln  Gly Pro Glu Ala Lys  Ile Lys Phe Pro Lys  Phe Ser Met 
    5225                 5230                 5235             


Pro Lys  Ile Gly Ile Pro Gly  Val Lys Met Glu Gly  Gly Gly Ala 
    5240                 5245                 5250             


Glu Val  His Ala Gln Leu Pro  Ser Leu Glu Gly Asp  Leu Arg Gly 
    5255                 5260                 5265             


Pro Asp  Val Lys Leu Glu Gly  Pro Asp Val Ser Leu  Lys Gly Pro 
    5270                 5275                 5280             


Gly Val  Asp Leu Pro Ser Val  Asn Leu Ser Met Pro  Lys Val Ser 
    5285                 5290                 5295             


Gly Pro  Asp Leu Asp Leu Asn  Leu Lys Gly Pro Ser  Leu Lys Gly 
    5300                 5305                 5310             


Asp Leu  Asp Ala Ser Val Pro  Ser Met Lys Val His  Ala Pro Gly 
    5315                 5320                 5325             


Leu Asn  Leu Ser Gly Val Gly  Gly Lys Met Gln Val  Gly Gly Asp 
    5330                 5335                 5340             


Gly Val  Lys Val Pro Gly Ile  Asp Ala Thr Thr Lys  Leu Asn Val 
    5345                 5350                 5355             


Gly Ala  Pro Asp Val Thr Leu  Arg Gly Pro Ser Leu  Gln Gly Asp 
    5360                 5365                 5370             


Leu Ala  Val Ser Gly Asp Ile  Lys Cys Pro Lys Val  Ser Val Gly 
    5375                 5380                 5385             


Ala Pro  Asp Leu Ser Leu Glu  Ala Ser Glu Gly Ser  Ile Lys Leu 
    5390                 5395                 5400             


Pro Lys  Met Lys Leu Pro Gln  Phe Gly Ile Ser Thr  Pro Gly Ser 
    5405                 5410                 5415             


Asp Leu  His Val Asn Ala Lys  Gly Pro Gln Val Ser  Gly Glu Leu 
    5420                 5425                 5430             


Lys Gly  Pro Gly Val Asp Val  Asn Leu Lys Gly Pro  Arg Ile Ser 
    5435                 5440                 5445             


Ala Pro  Asn Val Asp Phe Asn  Leu Glu Gly Pro Lys  Val Lys Gly 
    5450                 5455                 5460             


Ser Leu  Gly Ala Thr Gly Glu  Ile Lys Gly Pro Thr  Val Gly Gly 
    5465                 5470                 5475             


Gly Leu  Pro Gly Ile Gly Val  Gln Gly Leu Glu Gly  Asn Leu Gln 
    5480                 5485                 5490             


Met Pro  Gly Ile Lys Ser Ser  Gly Cys Asp Val Asn  Leu Pro Gly 
    5495                 5500                 5505             


Val Asn  Val Lys Leu Pro Thr  Gly Gln Ile Ser Gly  Pro Glu Ile 
    5510                 5515                 5520             


Lys Gly  Gly Leu Lys Gly Ser  Glu Val Gly Phe His  Gly Ala Ala 
    5525                 5530                 5535             


Pro Asp  Ile Ser Val Lys Gly  Pro Ala Phe Asn Met  Ala Ser Pro 
    5540                 5545                 5550             


Glu Ser  Asp Phe Gly Ile Asn  Leu Lys Gly Pro Lys  Ile Lys Gly 
    5555                 5560                 5565             


Gly Ala  Asp Val Ser Gly Gly  Val Ser Ala Pro Asp  Ile Ser Leu 
    5570                 5575                 5580             


Gly Glu  Gly His Leu Ser Val  Lys Gly Ser Gly Gly  Glu Trp Lys 
    5585                 5590                 5595             


Gly Pro  Gln Val Ser Ser Ala  Leu Asn Leu Asp Thr  Ser Lys Phe 
    5600                 5605                 5610             


Ala Gly  Gly Leu His Phe Ser  Gly Pro Lys Val Glu  Gly Gly Val 
    5615                 5620                 5625             


Lys Gly  Gly Gln Ile Gly Leu  Gln Ala Pro Gly Leu  Ser Val Ser 
    5630                 5635                 5640             


Gly Pro  Gln Gly His Leu Glu  Ser Gly Ser Gly Lys  Val Thr Phe 
    5645                 5650                 5655             


Pro Lys  Met Lys Ile Pro Lys  Phe Thr Phe Ser Gly  Arg Glu Leu 
    5660                 5665                 5670             


Val Gly  Arg Glu Met Gly Val  Asp Val His Phe Pro  Lys Ala Glu 
    5675                 5680                 5685             


Ala Ser  Ile Gln Ala Gly Ala  Gly Asp Gly Glu Trp  Glu Glu Ser 
    5690                 5695                 5700             


Glu Val  Lys Leu Lys Lys Ser  Lys Ile Lys Met Pro  Lys Phe Asn 
    5705                 5710                 5715             


Phe Ser  Lys Pro Lys Gly Lys  Gly Gly Val Thr Gly  Ser Pro Glu 
    5720                 5725                 5730             


Ala Ser  Ile Ser Gly Ser Lys  Gly Asp Leu Lys Ser  Ser Lys Ala 
    5735                 5740                 5745             


Ser Leu  Gly Ser Leu Glu Gly  Glu Ala Glu Ala Glu  Ala Ser Ser 
    5750                 5755                 5760             


Pro Lys  Gly Lys Phe Ser Leu  Phe Lys Ser Lys Lys  Pro Arg His 
    5765                 5770                 5775             


Arg Ser  Asn Ser Phe Ser Asp  Glu Arg Glu Phe Ser  Gly Pro Ser 
    5780                 5785                 5790             


Thr Pro  Thr Gly Thr Leu Glu  Phe Glu Gly Gly Glu  Val Ser Leu 
    5795                 5800                 5805             


Glu Gly  Gly Lys Val Lys Gly  Lys His Gly Lys Leu  Lys Phe Gly 
    5810                 5815                 5820             


Thr Phe  Gly Gly Leu Gly Ser  Lys Ser Lys Gly His  Tyr Glu Val 
    5825                 5830                 5835             


Thr Gly  Ser Asp Asp Glu Thr  Gly Lys Leu Gln Gly  Ser Gly Val 
    5840                 5845                 5850             


Ser Leu  Ala Ser Lys Lys Ser  Arg Leu Ser Ser Ser  Ser Ser Asn 
    5855                 5860                 5865             


Asp Ser  Gly Asn Lys Val Gly  Ile Gln Leu Pro Glu  Val Glu Leu 
    5870                 5875                 5880             


Ser Val  Ser Thr Lys Lys Glu  
    5885                 5890 


<210>  7
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Leu Ser Ala Ala Ser Arg Val Val Ser Arg Ala Ala Val His Cys 
1               5                   10                  15      


Ala Leu Arg Ser Pro Pro Pro Glu Ala Arg Ala Leu Ala Met Ser Arg 
            20                  25                  30          


Pro Pro Pro Pro Arg Val Ala Ser Val Leu Gly Thr Met Glu Met Gly 
        35                  40                  45              


Arg Arg Met Asp Ala Pro Ala Ser Ala Ala Ala Val Arg Ala Phe Leu 
    50                  55                  60                  


Glu Arg Gly His Thr Glu Leu Asp Thr Ala Phe Met Tyr Ser Asp Gly 
65                  70                  75                  80  


Gln Ser Glu Thr Ile Leu Gly Gly Leu Gly Leu Gly Leu Gly Gly Gly 
                85                  90                  95      


Asp Cys Arg Val Lys Ile Ala Thr Lys Ala Asn Pro Trp Asp Gly Lys 
            100                 105                 110         


Ser Leu Lys Pro Asp Ser Val Arg Ser Gln Leu Glu Thr Ser Leu Lys 
        115                 120                 125             


Arg Leu Gln Cys Pro Gln Val Asp Leu Phe Tyr Leu His Ala Pro Asp 
    130                 135                 140                 


His Gly Thr Pro Val Glu Glu Thr Leu His Ala Cys Gln Arg Leu His 
145                 150                 155                 160 


Gln Glu Gly Lys Phe Val Glu Leu Gly Leu Ser Asn Tyr Ala Ser Trp 
                165                 170                 175     


Glu Val Ala Glu Ile Cys Thr Leu Cys Lys Ser Asn Gly Trp Ile Leu 
            180                 185                 190         


Pro Thr Val Tyr Gln Gly Met Tyr Asn Ala Thr Thr Arg Gln Val Glu 
        195                 200                 205             


Thr Glu Leu Phe Pro Cys Leu Arg His Phe Gly Leu Arg Phe Tyr Ala 
    210                 215                 220                 


Tyr Asn Pro Leu Ala Gly Gly Leu Leu Thr Gly Lys Tyr Lys Tyr Glu 
225                 230                 235                 240 


Asp Lys Asp Gly Lys Gln Pro Val Gly Arg Phe Phe Gly Asn Ser Trp 
                245                 250                 255     


Ala Glu Thr Tyr Arg Asn Arg Phe Trp Lys Glu His His Phe Glu Ala 
            260                 265                 270         


Ile Ala Leu Val Glu Lys Ala Leu Gln Ala Ala Tyr Gly Ala Ser Ala 
        275                 280                 285             


Pro Ser Val Thr Ser Ala Ala Leu Arg Trp Met Tyr His His Ser Gln 
    290                 295                 300                 


Leu Gln Gly Ala His Gly Asp Ala Val Ile Leu Gly Met Ser Ser Leu 
305                 310                 315                 320 


Glu Gln Leu Glu Gln Asn Leu Ala Ala Thr Glu Glu Gly Pro Leu Glu 
                325                 330                 335     


Pro Ala Val Val Asp Ala Phe Asn Gln Ala Trp His Leu Val Ala His 
            340                 345                 350         


Glu Cys Pro Asn Tyr Phe Arg 
        355                 


<210>  8
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Val Arg Met Val Pro Val Leu Leu Ser Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Pro Ala Val Pro Gln Glu Asn Gln Asp Gly Arg Tyr Ser Leu Thr Tyr 
            20                  25                  30          


Ile Tyr Thr Gly Leu Ser Lys His Val Glu Asp Val Pro Ala Phe Gln 
        35                  40                  45              


Ala Leu Gly Ser Leu Asn Asp Leu Gln Phe Phe Arg Tyr Asn Ser Lys 
    50                  55                  60                  


Asp Arg Lys Ser Gln Pro Met Gly Leu Trp Arg Gln Val Glu Gly Met 
65                  70                  75                  80  


Glu Asp Trp Lys Gln Asp Ser Gln Leu Gln Lys Ala Arg Glu Asp Ile 
                85                  90                  95      


Phe Met Glu Thr Leu Lys Asp Ile Val Glu Tyr Tyr Asn Asp Ser Asn 
            100                 105                 110         


Gly Ser His Val Leu Gln Gly Arg Phe Gly Cys Glu Ile Glu Asn Asn 
        115                 120                 125             


Arg Ser Ser Gly Ala Phe Trp Lys Tyr Tyr Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Glu Phe Asn Lys Glu Ile Pro Ala Trp Val Pro Phe Asp Pro Ala 
145                 150                 155                 160 


Ala Gln Ile Thr Lys Gln Lys Trp Glu Ala Glu Pro Val Tyr Val Gln 
                165                 170                 175     


Arg Ala Lys Ala Tyr Leu Glu Glu Glu Cys Pro Ala Thr Leu Arg Lys 
            180                 185                 190         


Tyr Leu Lys Tyr Ser Lys Asn Ile Leu Asp Arg Gln Asp Pro Pro Ser 
        195                 200                 205             


Val Val Val Thr Ser His Gln Ala Pro Gly Glu Lys Lys Lys Leu Lys 
    210                 215                 220                 


Cys Leu Ala Tyr Asp Phe Tyr Pro Gly Lys Ile Asp Val His Trp Thr 
225                 230                 235                 240 


Arg Ala Gly Glu Val Gln Glu Pro Glu Leu Arg Gly Asp Val Leu His 
                245                 250                 255     


Asn Gly Asn Gly Thr Tyr Gln Ser Trp Val Val Val Ala Val Pro Pro 
            260                 265                 270         


Gln Asp Thr Ala Pro Tyr Ser Cys His Val Gln His Ser Ser Leu Ala 
        275                 280                 285             


Gln Pro Leu Val Val Pro Trp Glu Ala Ser 
    290                 295             


<210>  9
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15      


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30          


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45              


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60                  


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80  


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95      


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110         


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125             


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140                 


Gln Ile Asn Thr Asp Ser Phe Ser Ser Tyr Pro Val Phe Ser Pro Val 
145                 150                 155                 160 


Ser Leu Asp Tyr Ser Ser Glu Pro Ala Thr Val Thr Gln Val Thr Gln 
                165                 170                 175     


Gly Thr Ile Arg Pro Ala Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu 
            180                 185                 190         


Ile Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile 
        195                 200                 205             


Val Asp Val Val Ala Asn Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys 
    210                 215                 220                 


Ala Ala Phe Lys Thr Ser Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys 
225                 230                 235                 240 


Ser Glu Leu Ser Gly Asn Met Glu Glu Leu Ile Leu Ala Leu Phe Met 
                245                 250                 255     


Pro Pro Thr Tyr Tyr Asp Ala Trp Ser Leu Arg Lys Ala Met Gln Gly 
            260                 265                 270         


Ala Gly Thr Gln Glu Arg Val Leu Ile Glu Ile Leu Cys Thr Arg Thr 
        275                 280                 285             


Asn Gln Glu Ile Arg Glu Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly 
    290                 295                 300                 


Arg Asp Leu Glu Lys Asp Ile Arg Ser Asp Thr Ser Gly His Phe Glu 
305                 310                 315                 320 


Arg Leu Leu Val Ser Met Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser 
                325                 330                 335     


Ile Asn His Gln Met Ala Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala 
            340                 345                 350         


Gly Glu Gly Arg Leu Gly Thr Asp Glu Ser Cys Phe Asn Met Ile Leu 
        355                 360                 365             


Ala Thr Arg Ser Phe Pro Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser 
    370                 375                 380                 


Arg Met Ala Asn Arg Asp Leu Leu Ser Ser Val Ser Arg Glu Phe Ser 
385                 390                 395                 400 


Gly Tyr Val Glu Ser Gly Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn 
                405                 410                 415     


Arg Pro Ala Phe Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala 
            420                 425                 430         


Gly Thr Asp Asp Ser Thr Leu Val Arg Ile Val Val Thr Arg Ser Glu 
        435                 440                 445             


Ile Asp Leu Val Gln Ile Lys Gln Met Phe Ala Gln Met Tyr Gln Lys 
    450                 455                 460                 


Thr Leu Gly Thr Met Ile Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg 
465                 470                 475                 480 


Leu Leu Leu Ala Ile Val Gly Gln 
                485             


<210>  10
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg 
1               5                   10                  15      


Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala 
            20                  25                  30          


Ala Arg Asn Phe His Ala Ser Asn Thr His Leu Gln Lys Thr Gly Thr 
        35                  40                  45              


Ala Glu Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Thr 
    50                  55                  60                  


Ser Val Asp Leu Glu Glu Thr Gly Arg Val Leu Ser Ile Gly Asp Gly 
65                  70                  75                  80  


Ile Ala Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val 
                85                  90                  95      


Glu Phe Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp 
            100                 105                 110         


Asn Val Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly 
        115                 120                 125             


Asp Ile Val Lys Arg Thr Gly Ala Ile Val Asp Val Pro Val Gly Glu 
    130                 135                 140                 


Glu Leu Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly 
145                 150                 155                 160 


Lys Gly Pro Ile Gly Ser Lys Thr Arg Arg Arg Val Gly Leu Lys Ala 
                165                 170                 175     


Pro Gly Ile Ile Pro Arg Ile Ser Val Arg Glu Pro Met Gln Thr Gly 
            180                 185                 190         


Ile Lys Ala Val Asp Ser Leu Val Pro Ile Gly Arg Gly Gln Arg Glu 
        195                 200                 205             


Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr Ser Ile Ala Ile Asp 
    210                 215                 220                 


Thr Ile Ile Asn Gln Lys Arg Phe Asn Asp Gly Ser Asp Glu Lys Lys 
225                 230                 235                 240 


Lys Leu Tyr Cys Ile Tyr Val Ala Ile Gly Gln Lys Arg Ser Thr Val 
                245                 250                 255     


Ala Gln Leu Val Lys Arg Leu Thr Asp Ala Asp Ala Met Lys Tyr Thr 
            260                 265                 270         


Ile Val Val Ser Ala Thr Ala Ser Asp Ala Ala Pro Leu Gln Tyr Leu 
        275                 280                 285             


Ala Pro Tyr Ser Gly Cys Ser Met Gly Glu Tyr Phe Arg Asp Asn Gly 
    290                 295                 300                 


Lys His Ala Leu Ile Ile Tyr Asp Asp Leu Ser Lys Gln Ala Val Ala 
305                 310                 315                 320 


Tyr Arg Gln Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala 
                325                 330                 335     


Tyr Pro Gly Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala 
            340                 345                 350         


Ala Lys Met Asn Asp Ala Phe Gly Gly Gly Ser Leu Thr Ala Leu Pro 
        355                 360                 365             


Val Ile Glu Thr Gln Ala Gly Asp Val Ser Ala Tyr Ile Pro Thr Asn 
    370                 375                 380                 


Val Ile Ser Ile Thr Asp Gly Gln Ile Phe Leu Glu Thr Glu Leu Phe 
385                 390                 395                 400 


Tyr Lys Gly Ile Arg Pro Ala Ile Asn Val Gly Leu Ser Val Ser Arg 
                405                 410                 415     


Val Gly Ser Ala Ala Gln Thr Arg Ala Met Lys Gln Val Ala Gly Thr 
            420                 425                 430         


Met Lys Leu Glu Leu Ala Gln Tyr Arg Glu Val Ala Ala Phe Ala Gln 
        435                 440                 445             


Phe Gly Ser Asp Leu Asp Ala Ala Thr Gln Gln Leu Leu Ser Arg Gly 
    450                 455                 460                 


Val Arg Leu Thr Glu Leu Leu Lys Gln Gly Gln Tyr Ser Pro Met Ala 
465                 470                 475                 480 


Ile Glu Glu Gln Val Ala Val Ile Tyr Ala Gly Val Arg Gly Tyr Leu 
                485                 490                 495     


Asp Lys Leu Glu Pro Ser Lys Ile Thr Lys Phe Glu Asn Ala Phe Leu 
            500                 505                 510         


Ser His Val Val Ser Gln His Gln Ala Leu Leu Gly Thr Ile Arg Ala 
        515                 520                 525             


Asp Gly Lys Ile Ser Glu Gln Ser Asp Ala Lys Leu Lys Glu Ile Val 
    530                 535                 540                 


Thr Asn Phe Leu Ala Gly Phe Glu Ala 
545                 550             


<210>  11
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Trp Pro Leu Trp Arg Leu Val Ser Leu Leu Ala Leu Ser Gln Ala 
1               5                   10                  15      


Leu Pro Phe Glu Gln Arg Gly Phe Trp Asp Phe Thr Leu Asp Asp Gly 
            20                  25                  30          


Pro Phe Met Met Asn Asp Glu Glu Ala Ser Gly Ala Asp Thr Ser Gly 
        35                  40                  45              


Val Leu Asp Pro Asp Ser Val Thr Pro Thr Tyr Ser Ala Met Cys Pro 
    50                  55                  60                  


Phe Gly Cys His Cys His Leu Arg Val Val Gln Cys Ser Asp Leu Gly 
65                  70                  75                  80  


Leu Lys Ser Val Pro Lys Glu Ile Ser Pro Asp Thr Thr Leu Leu Asp 
                85                  90                  95      


Leu Gln Asn Asn Asp Ile Ser Glu Leu Arg Lys Asp Asp Phe Lys Gly 
            100                 105                 110         


Leu Gln His Leu Tyr Ala Leu Val Leu Val Asn Asn Lys Ile Ser Lys 
        115                 120                 125             


Ile His Glu Lys Ala Phe Ser Pro Leu Arg Lys Leu Gln Lys Leu Tyr 
    130                 135                 140                 


Ile Ser Lys Asn His Leu Val Glu Ile Pro Pro Asn Leu Pro Ser Ser 
145                 150                 155                 160 


Leu Val Glu Leu Arg Ile His Asp Asn Arg Ile Arg Lys Val Pro Lys 
                165                 170                 175     


Gly Val Phe Ser Gly Leu Arg Asn Met Asn Cys Ile Glu Met Gly Gly 
            180                 185                 190         


Asn Pro Leu Glu Asn Ser Gly Phe Glu Pro Gly Ala Phe Asp Gly Leu 
        195                 200                 205             


Lys Leu Asn Tyr Leu Arg Ile Ser Glu Ala Lys Leu Thr Gly Ile Pro 
    210                 215                 220                 


Lys Asp Leu Pro Glu Thr Leu Asn Glu Leu His Leu Asp His Asn Lys 
225                 230                 235                 240 


Ile Gln Ala Ile Glu Leu Glu Asp Leu Leu Arg Tyr Ser Lys Leu Tyr 
                245                 250                 255     


Arg Leu Gly Leu Gly His Asn Gln Ile Arg Met Ile Glu Asn Gly Ser 
            260                 265                 270         


Leu Ser Phe Leu Pro Thr Leu Arg Glu Leu His Leu Asp Asn Asn Lys 
        275                 280                 285             


Leu Ala Arg Val Pro Ser Gly Leu Pro Asp Leu Lys Leu Leu Gln Val 
    290                 295                 300                 


Val Tyr Leu His Ser Asn Asn Ile Thr Lys Val Gly Val Asn Asp Phe 
305                 310                 315                 320 


Cys Pro Met Gly Phe Gly Val Lys Arg Ala Tyr Tyr Asn Gly Ile Ser 
                325                 330                 335     


Leu Phe Asn Asn Pro Val Pro Tyr Trp Glu Val Gln Pro Ala Thr Phe 
            340                 345                 350         


Arg Cys Val Thr Asp Arg Leu Ala Ile Gln Phe Gly Asn Tyr Lys Lys 
        355                 360                 365             


<210>  12
<211>  882
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val 
    370                 375                 380                 


Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp 
385                 390                 395                 400 


Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu 
                405                 410                 415     


Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn 
            420                 425                 430         


Asp Gly Ile Leu Lys Thr Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln 
        435                 440                 445             


Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro Phe Glu Val 
    450                 455                 460                 


Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val Leu Asp Val 
465                 470                 475                 480 


Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val Glu Val Ser 
                485                 490                 495     


Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu 
            500                 505                 510         


Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp 
        515                 520                 525             


Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr 
    530                 535                 540                 


Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr 
545                 550                 555                 560 


Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr 
                565                 570                 575     


Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala 
            580                 585                 590         


Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys 
        595                 600                 605             


Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser 
    610                 615                 620                 


Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile 
625                 630                 635                 640 


Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met 
                645                 650                 655     


Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn 
            660                 665                 670         


Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys 
        675                 680                 685             


Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly 
    690                 695                 700                 


Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu 
705                 710                 715                 720 


Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val 
                725                 730                 735     


Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val 
            740                 745                 750         


Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp 
        755                 760                 765             


Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg 
    770                 775                 780                 


Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg 
785                 790                 795                 800 


Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys 
                805                 810                 815     


Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val 
            820                 825                 830         


Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu 
        835                 840                 845             


Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu 
    850                 855                 860                 


Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu 
865                 870                 875                 880 


Asp Asp 
        


<210>  13
<211>  3354
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val 
1               5                   10                  15      


Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr 
            20                  25                  30          


Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val 
        35                  40                  45              


Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro 
    50                  55                  60                  


Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val 
65                  70                  75                  80  


Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu 
                85                  90                  95      


Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly 
            100                 105                 110         


Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn 
        115                 120                 125             


Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn 
    130                 135                 140                 


Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln 
                165                 170                 175     


Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu 
            180                 185                 190         


Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr 
        195                 200                 205             


Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile 
    210                 215                 220                 


Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro 
225                 230                 235                 240 


Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg 
                245                 250                 255     


Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly 
            260                 265                 270         


Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr 
        275                 280                 285             


Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro 
    290                 295                 300                 


Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn 
305                 310                 315                 320 


Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile 
                325                 330                 335     


Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu 
            340                 345                 350         


Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro 
        355                 360                 365             


Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser 
    370                 375                 380                 


Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile 
385                 390                 395                 400 


Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala 
                405                 410                 415     


Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe 
            420                 425                 430         


Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile 
        435                 440                 445             


Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu 
    450                 455                 460                 


Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu 
465                 470                 475                 480 


Thr Val Leu Ala Thr Asp Asn Asp Ala Gly Thr Phe Gly Glu Val Ser 
                485                 490                 495     


Tyr Phe Phe Ser Asp Asp Pro Asp Arg Phe Ser Leu Asp Lys Asp Thr 
            500                 505                 510         


Gly Leu Ile Met Leu Ile Ala Arg Leu Asp Tyr Glu Leu Ile Gln Arg 
        515                 520                 525             


Phe Thr Leu Thr Ile Ile Ala Arg Asp Gly Gly Gly Glu Glu Thr Thr 
    530                 535                 540                 


Gly Arg Val Arg Ile Asn Val Leu Asp Val Asn Asp Asn Val Pro Thr 
545                 550                 555                 560 


Phe Gln Lys Asp Ala Tyr Val Gly Ala Leu Arg Glu Asn Glu Pro Ser 
                565                 570                 575     


Val Thr Gln Leu Val Arg Leu Arg Ala Thr Asp Glu Asp Ser Pro Pro 
            580                 585                 590         


Asn Asn Gln Ile Thr Tyr Ser Ile Val Ser Ala Ser Ala Phe Gly Ser 
        595                 600                 605             


Tyr Phe Asp Ile Ser Leu Tyr Glu Gly Tyr Gly Val Ile Ser Val Ser 
    610                 615                 620                 


Arg Pro Leu Asp Tyr Glu Gln Ile Ser Asn Gly Leu Ile Tyr Leu Thr 
625                 630                 635                 640 


Val Met Ala Met Asp Ala Gly Asn Pro Pro Leu Asn Ser Thr Val Pro 
                645                 650                 655     


Val Thr Ile Glu Val Phe Asp Glu Asn Asp Asn Pro Pro Thr Phe Ser 
            660                 665                 670         


Lys Pro Ala Tyr Phe Val Ser Val Val Glu Asn Ile Met Ala Gly Ala 
        675                 680                 685             


Thr Val Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu Tyr 
    690                 695                 700                 


Gly Gln Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr Gln Phe Arg 
705                 710                 715                 720 


Ile Asn Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu Leu Asp Arg 
                725                 730                 735     


Glu Thr Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val Asp Gly Gly 
            740                 745                 750         


Val Gly His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn Ile Thr Leu 
        755                 760                 765             


Leu Asp Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala Pro Tyr Tyr 
    770                 775                 780                 


Ile Asn Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val Thr Thr Val 
785                 790                 795                 800 


Val Ala Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu Val Tyr Ser 
                805                 810                 815     


Ile Gln Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr Thr Gly Lys 
            820                 825                 830         


Ile Arg Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro Asp Pro His 
        835                 840                 845             


Glu Ala Glu Leu Met Arg Lys Ile Val Val Ser Val Thr Asp Cys Gly 
    850                 855                 860                 


Arg Pro Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe Val Asn Leu 
865                 870                 875                 880 


Leu Asp Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu Pro Phe Val 
                885                 890                 895     


Ala Glu Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile Tyr Gln Val 
            900                 905                 910         


Val Ala Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val Ser Tyr Arg 
        915                 920                 925             


Met Pro Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn Ser Ser Ser 
    930                 935                 940                 


Gly Val Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg Ile Ala Glu 
945                 950                 955                 960 


Tyr Gln Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro Thr Lys Ser 
                965                 970                 975     


Ser Thr Ser Thr Leu Thr Ile His Val Leu Asp Val Asn Asp Glu Thr 
            980                 985                 990         


Pro Thr Phe Phe Pro Ala Val Tyr  Asn Val Ser Val Ser  Glu Asp Val 
        995                 1000                 1005             


Pro Arg  Glu Phe Arg Val Val  Trp Leu Asn Cys Thr  Asp Asn Asp 
    1010                 1015                 1020             


Val Gly  Leu Asn Ala Glu Leu  Ser Tyr Phe Ile Thr  Gly Gly Asn 
    1025                 1030                 1035             


Val Asp  Gly Lys Phe Ser Val  Gly Tyr Arg Asp Ala  Val Val Arg 
    1040                 1045                 1050             


Thr Val  Val Gly Leu Asp Arg  Glu Thr Thr Ala Ala  Tyr Met Leu 
    1055                 1060                 1065             


Ile Leu  Glu Ala Ile Asp Asn  Gly Pro Val Gly Lys  Arg His Thr 
    1070                 1075                 1080             


Gly Thr  Ala Thr Val Phe Val  Thr Val Leu Asp Val  Asn Asp Asn 
    1085                 1090                 1095             


Arg Pro  Ile Phe Leu Gln Ser  Ser Tyr Glu Ala Ser  Val Pro Glu 
    1100                 1105                 1110             


Asp Ile  Pro Glu Gly His Ser  Ile Leu Gln Leu Lys  Ala Thr Asp 
    1115                 1120                 1125             


Ala Asp  Glu Gly Glu Phe Gly  Arg Val Trp Tyr Arg  Ile Leu His 
    1130                 1135                 1140             


Gly Asn  His Gly Asn Asn Phe  Arg Ile His Val Ser  Asn Gly Leu 
    1145                 1150                 1155             


Leu Met  Arg Gly Pro Arg Pro  Leu Asp Arg Glu Arg  Asn Ser Ser 
    1160                 1165                 1170             


His Val  Leu Ile Val Glu Ala  Tyr Asn His Asp Leu  Gly Pro Met 
    1175                 1180                 1185             


Arg Ser  Ser Val Arg Val Ile  Val Tyr Val Glu Asp  Ile Asn Asp 
    1190                 1195                 1200             


Glu Ala  Pro Val Phe Thr Gln  Gln Gln Tyr Ser Arg  Leu Gly Leu 
    1205                 1210                 1215             


Arg Glu  Thr Ala Gly Ile Gly  Thr Ser Val Ile Val  Val Gln Ala 
    1220                 1225                 1230             


Thr Asp  Arg Asp Ser Gly Asp  Gly Gly Leu Val Asn  Tyr Arg Ile 
    1235                 1240                 1245             


Leu Ser  Gly Ala Glu Gly Lys  Phe Glu Ile Asp Glu  Ser Thr Gly 
    1250                 1255                 1260             


Leu Ile  Ile Thr Val Asn Tyr  Leu Asp Tyr Glu Thr  Lys Thr Ser 
    1265                 1270                 1275             


Tyr Met  Met Asn Val Ser Ala  Thr Asp Gln Ala Pro  Pro Phe Asn 
    1280                 1285                 1290             


Gln Gly  Phe Cys Ser Val Tyr  Ile Thr Leu Leu Asn  Glu Leu Asp 
    1295                 1300                 1305             


Glu Ala  Val Gln Phe Ser Asn  Ala Ser Tyr Glu Ala  Ala Ile Leu 
    1310                 1315                 1320             


Glu Asn  Leu Ala Leu Gly Thr  Glu Ile Val Arg Val  Gln Ala Tyr 
    1325                 1330                 1335             


Ser Ile  Asp Asn Leu Asn Gln  Ile Thr Tyr Arg Phe  Asp Ala Tyr 
    1340                 1345                 1350             


Thr Ser  Thr Gln Ala Lys Ala  Leu Phe Lys Ile Asp  Ala Ile Thr 
    1355                 1360                 1365             


Gly Val  Ile Thr Val Gln Gly  Leu Val Asp Arg Glu  Lys Gly Asp 
    1370                 1375                 1380             


Phe Tyr  Thr Leu Thr Val Val  Ala Asp Asp Gly Gly  Pro Lys Val 
    1385                 1390                 1395             


Asp Ser  Thr Val Lys Val Tyr  Ile Thr Val Leu Asp  Glu Asn Asp 
    1400                 1405                 1410             


Asn Ser  Pro Arg Phe Asp Phe  Thr Ser Asp Ser Ala  Val Ser Ile 
    1415                 1420                 1425             


Pro Glu  Asp Cys Pro Val Gly  Gln Arg Val Ala Thr  Val Lys Ala 
    1430                 1435                 1440             


Trp Asp  Pro Asp Ala Gly Ser  Asn Gly Gln Val Val  Phe Ser Leu 
    1445                 1450                 1455             


Ala Ser  Gly Asn Ile Ala Gly  Ala Phe Glu Ile Val  Thr Thr Asn 
    1460                 1465                 1470             


Asp Ser  Ile Gly Glu Val Phe  Val Ala Arg Pro Leu  Asp Arg Glu 
    1475                 1480                 1485             


Glu Leu  Asp His Tyr Ile Leu  Gln Val Val Ala Ser  Asp Arg Gly 
    1490                 1495                 1500             


Thr Pro  Pro Arg Lys Lys Asp  His Ile Leu Gln Val  Thr Ile Leu 
    1505                 1510                 1515             


Asp Ile  Asn Asp Asn Pro Pro  Val Ile Glu Ser Pro  Phe Gly Tyr 
    1520                 1525                 1530             


Asn Val  Ser Val Asn Glu Asn  Val Gly Gly Gly Thr  Ala Val Val 
    1535                 1540                 1545             


Gln Val  Arg Ala Thr Asp Arg  Asp Ile Gly Ile Asn  Ser Val Leu 
    1550                 1555                 1560             


Ser Tyr  Tyr Ile Thr Glu Gly  Asn Lys Asp Met Thr  Phe Arg Met 
    1565                 1570                 1575             


Asp Arg  Ile Ser Gly Glu Ile  Ala Thr Arg Pro Ala  Pro Pro Asp 
    1580                 1585                 1590             


Arg Glu  Arg Gln Ser Phe Tyr  His Leu Val Ala Thr  Val Glu Asp 
    1595                 1600                 1605             


Glu Gly  Thr Pro Thr Leu Ser  Ala Thr Thr His Val  Tyr Val Thr 
    1610                 1615                 1620             


Ile Val  Asp Glu Asn Asp Asn  Ala Pro Met Phe Gln  Gln Pro His 
    1625                 1630                 1635             


Tyr Glu  Val Leu Leu Asp Glu  Gly Pro Asp Thr Leu  Asn Thr Ser 
    1640                 1645                 1650             


Leu Ile  Thr Ile Gln Ala Leu  Asp Leu Asp Glu Gly  Pro Asn Gly 
    1655                 1660                 1665             


Thr Val  Thr Tyr Ala Ile Val  Ala Gly Asn Ile Val  Asn Thr Phe 
    1670                 1675                 1680             


Arg Ile  Asp Arg His Met Gly  Val Ile Thr Ala Ala  Lys Glu Leu 
    1685                 1690                 1695             


Asp Tyr  Glu Ile Ser His Gly  Arg Tyr Thr Leu Ile  Val Thr Ala 
    1700                 1705                 1710             


Thr Asp  Gln Cys Pro Ile Leu  Ser His Arg Leu Thr  Ser Thr Thr 
    1715                 1720                 1725             


Thr Val  Leu Val Asn Val Asn  Asp Ile Asn Asp Asn  Val Pro Thr 
    1730                 1735                 1740             


Phe Pro  Arg Asp Tyr Glu Gly  Pro Phe Glu Val Thr  Glu Gly Gln 
    1745                 1750                 1755             


Pro Gly  Pro Arg Val Trp Thr  Phe Leu Ala His Asp  Arg Asp Ser 
    1760                 1765                 1770             


Gly Pro  Asn Gly Gln Val Glu  Tyr Ser Ile Met Asp  Gly Asp Pro 
    1775                 1780                 1785             


Leu Gly  Glu Phe Val Ile Ser  Pro Val Glu Gly Val  Leu Arg Val 
    1790                 1795                 1800             


Arg Lys  Asp Val Glu Leu Asp  Arg Glu Thr Ile Ala  Phe Tyr Asn 
    1805                 1810                 1815             


Leu Thr  Ile Cys Ala Arg Asp  Arg Gly Met Pro Pro  Leu Ser Ser 
    1820                 1825                 1830             


Thr Met  Leu Val Gly Ile Arg  Val Leu Asp Ile Asn  Asp Asn Asp 
    1835                 1840                 1845             


Pro Val  Leu Leu Asn Leu Pro  Met Asn Ile Thr Ile  Ser Glu Asn 
    1850                 1855                 1860             


Ser Pro  Val Ser Ser Phe Val  Ala His Val Leu Ala  Ser Asp Ala 
    1865                 1870                 1875             


Asp Ser  Gly Cys Asn Ala Arg  Leu Thr Phe Asn Ile  Thr Ala Gly 
    1880                 1885                 1890             


Asn Arg  Glu Arg Ala Phe Phe  Ile Asn Ala Thr Thr  Gly Ile Val 
    1895                 1900                 1905             


Thr Val  Asn Arg Pro Leu Asp  Arg Glu Arg Ile Pro  Glu Tyr Lys 
    1910                 1915                 1920             


Leu Thr  Ile Ser Val Lys Asp  Asn Pro Glu Asn Pro  Arg Ile Ala 
    1925                 1930                 1935             


Arg Arg  Asp Tyr Asp Leu Leu  Leu Ile Phe Leu Ser  Asp Glu Asn 
    1940                 1945                 1950             


Asp Asn  His Pro Leu Phe Thr  Lys Ser Thr Tyr Gln  Ala Glu Val 
    1955                 1960                 1965             


Met Glu  Asn Ser Pro Ala Gly  Thr Pro Leu Thr Val  Leu Asn Gly 
    1970                 1975                 1980             


Pro Ile  Leu Ala Leu Asp Ala  Asp Gln Asp Ile Tyr  Ala Val Val 
    1985                 1990                 1995             


Thr Tyr  Gln Leu Leu Gly Ala  Gln Ser Gly Leu Phe  Asp Ile Asn 
    2000                 2005                 2010             


Ser Ser  Thr Gly Val Val Thr  Val Arg Ser Gly Val  Ile Ile Asp 
    2015                 2020                 2025             


Arg Glu  Ala Phe Ser Pro Pro  Ile Leu Glu Leu Leu  Leu Leu Ala 
    2030                 2035                 2040             


Glu Asp  Ile Gly Leu Leu Asn  Ser Thr Ala His Leu  Leu Ile Thr 
    2045                 2050                 2055             


Ile Leu  Asp Asp Asn Asp Asn  Arg Pro Thr Phe Ser  Pro Ala Thr 
    2060                 2065                 2070             


Leu Thr  Val His Leu Leu Glu  Asn Cys Pro Pro Gly  Phe Ser Val 
    2075                 2080                 2085             


Leu Gln  Val Thr Ala Thr Asp  Glu Asp Ser Gly Leu  Asn Gly Glu 
    2090                 2095                 2100             


Leu Val  Tyr Arg Ile Glu Ala  Gly Ala Gln Asp Arg  Phe Leu Ile 
    2105                 2110                 2115             


His Leu  Val Thr Gly Val Ile  Arg Val Gly Asn Ala  Thr Ile Asp 
    2120                 2125                 2130             


Arg Glu  Glu Gln Glu Ser Tyr  Arg Leu Thr Val Val  Ala Thr Asp 
    2135                 2140                 2145             


Arg Gly  Thr Val Pro Leu Ser  Gly Thr Ala Ile Val  Thr Ile Leu 
    2150                 2155                 2160             


Ile Asp  Asp Ile Asn Asp Ser  Arg Pro Glu Phe Leu  Asn Pro Ile 
    2165                 2170                 2175             


Gln Thr  Val Ser Val Leu Glu  Ser Ala Glu Pro Gly  Thr Val Ile 
    2180                 2185                 2190             


Ala Asn  Ile Thr Ala Ile Asp  His Asp Leu Asn Pro  Lys Leu Glu 
    2195                 2200                 2205             


Tyr His  Ile Val Gly Ile Val  Ala Lys Asp Asp Thr  Asp Arg Leu 
    2210                 2215                 2220             


Val Pro  Asn Gln Glu Asp Ala  Phe Ala Val Asn Ile  Asn Thr Gly 
    2225                 2230                 2235             


Ser Val  Met Val Lys Ser Pro  Met Asn Arg Glu Leu  Val Ala Thr 
    2240                 2245                 2250             


Tyr Glu  Val Thr Leu Ser Val  Ile Asp Asn Ala Ser  Asp Leu Pro 
    2255                 2260                 2265             


Glu Arg  Ser Val Ser Val Pro  Asn Ala Lys Leu Thr  Val Asn Val 
    2270                 2275                 2280             


Leu Asp  Val Asn Asp Asn Thr  Pro Gln Phe Lys Pro  Phe Gly Ile 
    2285                 2290                 2295             


Thr Tyr  Tyr Met Glu Arg Ile  Leu Glu Gly Ala Thr  Pro Gly Thr 
    2300                 2305                 2310             


Thr Leu  Ile Ala Val Ala Ala  Val Asp Pro Asp Lys  Gly Leu Asn 
    2315                 2320                 2325             


Gly Leu  Val Thr Tyr Thr Leu  Leu Asp Leu Val Pro  Pro Gly Tyr 
    2330                 2335                 2340             


Val Gln  Leu Glu Asp Ser Ser  Ala Gly Lys Val Ile  Ala Asn Arg 
    2345                 2350                 2355             


Thr Val  Asp Tyr Glu Glu Val  His Trp Leu Asn Phe  Thr Val Arg 
    2360                 2365                 2370             


Ala Ser  Asp Asn Gly Ser Pro  Pro Arg Ala Ala Glu  Ile Pro Val 
    2375                 2380                 2385             


Tyr Leu  Glu Ile Val Asp Ile  Asn Asp Asn Asn Pro  Ile Phe Asp 
    2390                 2395                 2400             


Gln Pro  Ser Tyr Gln Glu Ala  Val Phe Glu Asp Val  Pro Val Gly 
    2405                 2410                 2415             


Thr Ile  Ile Leu Thr Val Thr  Ala Thr Asp Ala Asp  Ser Gly Asn 
    2420                 2425                 2430             


Phe Ala  Leu Ile Glu Tyr Ser  Leu Gly Asp Gly Glu  Ser Lys Phe 
    2435                 2440                 2445             


Ala Ile  Asn Pro Thr Thr Gly  Asp Ile Tyr Val Leu  Ser Ser Leu 
    2450                 2455                 2460             


Asp Arg  Glu Lys Lys Asp His  Tyr Ile Leu Thr Ala  Leu Ala Lys 
    2465                 2470                 2475             


Asp Asn  Pro Gly Asp Val Ala  Ser Asn Arg Arg Glu  Asn Ser Val 
    2480                 2485                 2490             


Gln Val  Val Ile Gln Val Leu  Asp Val Asn Asp Cys  Arg Pro Gln 
    2495                 2500                 2505             


Phe Ser  Lys Pro Gln Phe Ser  Thr Ser Val Tyr Glu  Asn Glu Pro 
    2510                 2515                 2520             


Ala Gly  Thr Ser Val Ile Thr  Met Met Ala Thr Asp  Gln Asp Glu 
    2525                 2530                 2535             


Gly Pro  Asn Gly Glu Leu Thr  Tyr Ser Leu Glu Gly  Pro Gly Val 
    2540                 2545                 2550             


Glu Ala  Phe His Val Asp Met  Asp Ser Gly Leu Val  Thr Thr Gln 
    2555                 2560                 2565             


Arg Pro  Leu Gln Ser Tyr Glu  Lys Phe Ser Leu Thr  Val Val Ala 
    2570                 2575                 2580             


Thr Asp  Gly Gly Glu Pro Pro  Leu Trp Gly Thr Thr  Met Leu Leu 
    2585                 2590                 2595             


Val Glu  Val Ile Asp Val Asn  Asp Asn Arg Pro Val  Phe Val Arg 
    2600                 2605                 2610             


Pro Pro  Asn Gly Thr Ile Leu  His Ile Arg Glu Glu  Ile Pro Leu 
    2615                 2620                 2625             


Arg Ser  Asn Val Tyr Glu Val  Tyr Ala Thr Asp Lys  Asp Glu Gly 
    2630                 2635                 2640             


Leu Asn  Gly Ala Val Arg Tyr  Ser Phe Leu Lys Thr  Ala Gly Asn 
    2645                 2650                 2655             


Arg Asp  Trp Glu Phe Phe Ile  Ile Asp Pro Ile Ser  Gly Leu Ile 
    2660                 2665                 2670             


Gln Thr  Ala Gln Arg Leu Asp  Arg Glu Ser Gln Ala  Val Tyr Ser 
    2675                 2680                 2685             


Leu Ile  Leu Val Ala Ser Asp  Leu Gly Gln Pro Val  Pro Tyr Glu 
    2690                 2695                 2700             


Thr Met  Gln Pro Leu Gln Val  Ala Leu Glu Asp Ile  Asp Asp Asn 
    2705                 2710                 2715             


Glu Pro  Leu Phe Val Arg Pro  Pro Lys Gly Ser Pro  Gln Tyr Gln 
    2720                 2725                 2730             


Leu Leu  Thr Val Pro Glu His  Ser Pro Arg Gly Thr  Leu Val Gly 
    2735                 2740                 2745             


Asn Val  Thr Gly Ala Val Asp  Ala Asp Glu Gly Pro  Asn Ala Ile 
    2750                 2755                 2760             


Val Tyr  Tyr Phe Ile Ala Ala  Gly Asn Glu Glu Lys  Asn Phe His 
    2765                 2770                 2775             


Leu Gln  Pro Asp Gly Cys Leu  Leu Val Leu Arg Asp  Leu Asp Arg 
    2780                 2785                 2790             


Glu Arg  Glu Ala Ile Phe Ser  Phe Ile Val Lys Ala  Ser Ser Asn 
    2795                 2800                 2805             


Arg Ser  Trp Thr Pro Pro Arg  Gly Pro Ser Pro Thr  Leu Asp Leu 
    2810                 2815                 2820             


Val Ala  Asp Leu Thr Leu Gln  Glu Val Arg Val Val  Leu Glu Asp 
    2825                 2830                 2835             


Ile Asn  Asp Gln Pro Pro Arg  Phe Thr Lys Ala Glu  Tyr Thr Ala 
    2840                 2845                 2850             


Gly Val  Ala Thr Asp Ala Lys  Val Gly Ser Glu Leu  Ile Gln Val 
    2855                 2860                 2865             


Leu Ala  Leu Asp Ala Asp Ile  Gly Asn Asn Ser Leu  Val Phe Tyr 
    2870                 2875                 2880             


Ser Ile  Leu Ala Ile His Tyr  Phe Arg Ala Leu Ala  Asn Asp Ser 
    2885                 2890                 2895             


Glu Asp  Val Gly Gln Val Phe  Thr Met Gly Ser Met  Asp Gly Ile 
    2900                 2905                 2910             


Leu Arg  Thr Phe Asp Leu Phe  Met Ala Tyr Ser Pro  Gly Tyr Phe 
    2915                 2920                 2925             


Val Val  Asp Ile Val Ala Arg  Asp Leu Ala Gly His  Asn Asp Thr 
    2930                 2935                 2940             


Ala Ile  Ile Gly Ile Tyr Ile  Leu Arg Asp Asp Gln  Arg Val Lys 
    2945                 2950                 2955             


Ile Val  Ile Asn Glu Ile Pro  Asp Arg Val Arg Gly  Phe Glu Glu 
    2960                 2965                 2970             


Glu Phe  Ile His Leu Leu Ser  Asn Ile Thr Gly Ala  Ile Val Asn 
    2975                 2980                 2985             


Thr Asp  Asn Val Gln Phe His  Val Asp Lys Lys Gly  Arg Val Asn 
    2990                 2995                 3000             


Phe Ala  Gln Thr Glu Leu Leu  Ile His Val Val Asn  Arg Asp Thr 
    3005                 3010                 3015             


Asn Arg  Ile Leu Asp Val Asp  Arg Val Ile Gln Met  Ile Asp Glu 
    3020                 3025                 3030             


Asn Lys  Glu Gln Leu Arg Asn  Leu Phe Arg Asn Tyr  Asn Val Leu 
    3035                 3040                 3045             


Asp Val  Gln Pro Ala Ile Ser  Val Arg Leu Pro Asp  Asp Met Ser 
    3050                 3055                 3060             


Ala Leu  Gln Met Ala Ile Ile  Val Leu Ala Ile Leu  Leu Phe Leu 
    3065                 3070                 3075             


Ala Ala  Met Leu Phe Val Leu  Met Asn Trp Tyr Tyr  Arg Thr Val 
    3080                 3085                 3090             


His Lys  Arg Lys Leu Lys Ala  Ile Val Ala Gly Ser  Ala Gly Asn 
    3095                 3100                 3105             


Arg Gly  Phe Ile Asp Ile Met  Asp Met Pro Asn Thr  Asn Lys Tyr 
    3110                 3115                 3120             


Ser Phe  Asp Gly Ala Asn Pro  Val Trp Leu Asp Pro  Phe Cys Arg 
    3125                 3130                 3135             


Asn Leu  Glu Leu Ala Ala Gln  Ala Glu His Glu Asp  Asp Leu Pro 
    3140                 3145                 3150             


Glu Asn  Leu Ser Glu Ile Ala  Asp Leu Trp Asn Ser  Pro Thr Arg 
    3155                 3160                 3165             


Thr His  Gly Thr Phe Gly Arg  Glu Pro Ala Ala Val  Lys Pro Asp 
    3170                 3175                 3180             


Asp Asp  Arg Tyr Leu Arg Ala  Ala Ile Gln Glu Tyr  Asp Asn Ile 
    3185                 3190                 3195             


Ala Lys  Leu Gly Gln Ile Ile  Arg Glu Gly Pro Ile  Lys Gly Ser 
    3200                 3205                 3210             


Leu Leu  Lys Val Val Leu Glu  Asp Tyr Leu Arg Leu  Lys Lys Leu 
    3215                 3220                 3225             


Phe Ala  Gln Arg Met Val Gln  Lys Ala Ser Ser Cys  His Ser Ser 
    3230                 3235                 3240             


Ile Ser  Glu Leu Ile Gln Thr  Glu Leu Asp Glu Glu  Pro Gly Asp 
    3245                 3250                 3255             


His Ser  Pro Gly Gln Gly Ser  Leu Arg Phe Arg His  Lys Pro Pro 
    3260                 3265                 3270             


Val Glu  Leu Lys Gly Pro Asp  Gly Ile His Val Val  His Gly Ser 
    3275                 3280                 3285             


Thr Gly  Thr Leu Leu Ala Thr  Asp Leu Asn Ser Leu  Pro Glu Glu 
    3290                 3295                 3300             


Asp Gln  Lys Gly Leu Gly Arg  Ser Leu Glu Thr Leu  Thr Ala Ala 
    3305                 3310                 3315             


Glu Ala  Thr Ala Phe Glu Arg  Asn Ala Arg Thr Glu  Ser Ala Lys 
    3320                 3325                 3330             


Ser Thr  Pro Leu His Lys Leu  Arg Asp Val Ile Met  Glu Thr Pro 
    3335                 3340                 3345             


Leu Glu  Ile Thr Glu Leu 
    3350                 


<210>  14
<211>  2225
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Ala Leu Val Leu Glu Asp Gly Ser Val Leu Arg Gly Gln Pro 
1               5                   10                  15      


Phe Gly Ala Ala Val Ser Thr Ala Gly Glu Val Val Phe Gln Thr Gly 
            20                  25                  30          


Met Val Gly Tyr Pro Glu Ala Leu Thr Asp Pro Ser Tyr Lys Ala Gln 
        35                  40                  45              


Ile Leu Val Leu Thr Tyr Pro Leu Ile Gly Asn Tyr Gly Ile Pro Pro 
    50                  55                  60                  


Asp Glu Met Asp Glu Phe Gly Leu Cys Lys Trp Phe Glu Ser Ser Gly 
65                  70                  75                  80  


Ile His Val Ala Ala Leu Val Val Gly Glu Cys Cys Pro Thr Pro Ser 
                85                  90                  95      


His Trp Ser Ala Thr Arg Thr Leu His Glu Trp Leu Gln Gln His Gly 
            100                 105                 110         


Ile Pro Gly Leu Gln Gly Val Asp Thr Arg Glu Leu Thr Lys Lys Leu 
        115                 120                 125             


Arg Glu Gln Gly Ser Leu Leu Gly Lys Leu Val Gln Asn Gly Thr Glu 
    130                 135                 140                 


Pro Ser Ser Leu Pro Phe Leu Asp Pro Asn Ala Arg Pro Leu Val Pro 
145                 150                 155                 160 


Glu Val Ser Ile Lys Thr Pro Arg Val Phe Asn Thr Gly Gly Ala Pro 
                165                 170                 175     


Arg Ile Leu Ala Leu Asp Cys Gly Leu Lys Tyr Asn Gln Ile Arg Cys 
            180                 185                 190         


Leu Cys Gln Arg Gly Ala Glu Val Thr Val Val Pro Trp Asp His Ala 
        195                 200                 205             


Leu Asp Ser Gln Glu Tyr Glu Gly Leu Phe Leu Ser Asn Gly Pro Gly 
    210                 215                 220                 


Asp Pro Ala Ser Tyr Pro Ser Val Val Ser Thr Leu Ser Arg Val Leu 
225                 230                 235                 240 


Ser Glu Pro Asn Pro Arg Pro Val Phe Gly Ile Cys Leu Gly His Gln 
                245                 250                 255     


Leu Leu Ala Leu Ala Ile Gly Ala Lys Thr Tyr Lys Met Arg Tyr Gly 
            260                 265                 270         


Asn Arg Gly His Asn Gln Pro Cys Leu Leu Val Gly Ser Gly Arg Cys 
        275                 280                 285             


Phe Leu Thr Ser Gln Asn His Gly Phe Ala Val Glu Thr Asp Ser Leu 
    290                 295                 300                 


Pro Ala Asp Trp Ala Pro Leu Phe Thr Asn Ala Asn Asp Gly Ser Asn 
305                 310                 315                 320 


Glu Gly Ile Val His Asn Ser Leu Pro Phe Phe Ser Val Gln Phe His 
                325                 330                 335     


Pro Glu His Gln Ala Gly Pro Ser Asp Met Glu Leu Leu Phe Asp Ile 
            340                 345                 350         


Phe Leu Glu Thr Val Lys Glu Ala Thr Ala Gly Asn Pro Gly Gly Gln 
        355                 360                 365             


Thr Val Arg Glu Arg Leu Thr Glu Arg Leu Cys Pro Pro Gly Ile Pro 
    370                 375                 380                 


Thr Pro Gly Ser Gly Leu Pro Pro Pro Arg Lys Val Leu Ile Leu Gly 
385                 390                 395                 400 


Ser Gly Gly Leu Ser Ile Gly Gln Ala Gly Glu Phe Asp Tyr Ser Gly 
                405                 410                 415     


Ser Gln Ala Ile Lys Ala Leu Lys Glu Glu Asn Ile Gln Thr Leu Leu 
            420                 425                 430         


Ile Asn Pro Asn Ile Ala Thr Val Gln Thr Ser Gln Gly Leu Ala Asp 
        435                 440                 445             


Lys Val Tyr Phe Leu Pro Ile Thr Pro His Tyr Val Thr Gln Val Ile 
    450                 455                 460                 


Arg Asn Glu Arg Pro Asp Gly Val Leu Leu Thr Phe Gly Gly Gln Thr 
465                 470                 475                 480 


Ala Leu Asn Cys Gly Val Glu Leu Thr Lys Ala Gly Val Leu Ala Arg 
                485                 490                 495     


Tyr Gly Val Arg Val Leu Gly Thr Pro Val Glu Thr Ile Glu Leu Thr 
            500                 505                 510         


Glu Asp Arg Arg Ala Phe Ala Ala Arg Met Ala Glu Ile Gly Glu His 
        515                 520                 525             


Val Ala Pro Ser Glu Ala Ala Asn Ser Leu Glu Gln Ala Gln Ala Ala 
    530                 535                 540                 


Ala Glu Arg Leu Gly Tyr Pro Val Leu Val Arg Ala Ala Phe Ala Leu 
545                 550                 555                 560 


Gly Gly Leu Gly Ser Gly Phe Ala Ser Asn Arg Glu Glu Leu Ser Ala 
                565                 570                 575     


Leu Val Ala Pro Ala Phe Ala His Thr Ser Gln Val Leu Val Asp Lys 
            580                 585                 590         


Ser Leu Lys Gly Trp Lys Glu Ile Glu Tyr Glu Val Val Arg Asp Ala 
        595                 600                 605             


Tyr Gly Asn Cys Val Thr Val Cys Asn Met Glu Asn Leu Asp Pro Leu 
    610                 615                 620                 


Gly Ile His Thr Gly Glu Ser Ile Val Val Ala Pro Ser Gln Thr Leu 
625                 630                 635                 640 


Asn Asp Arg Glu Tyr Gln Leu Leu Arg Gln Thr Ala Ile Lys Val Thr 
                645                 650                 655     


Gln His Leu Gly Ile Val Gly Glu Cys Asn Val Gln Tyr Ala Leu Asn 
            660                 665                 670         


Pro Glu Ser Glu Gln Tyr Tyr Ile Ile Glu Val Asn Ala Arg Leu Ser 
        675                 680                 685             


Arg Ser Ser Ala Leu Ala Ser Lys Ala Thr Gly Tyr Pro Leu Ala Tyr 
    690                 695                 700                 


Val Ala Ala Lys Leu Ala Leu Gly Ile Pro Leu Pro Glu Leu Arg Asn 
705                 710                 715                 720 


Ser Val Thr Gly Gly Thr Ala Ala Phe Glu Pro Ser Val Asp Tyr Cys 
                725                 730                 735     


Val Val Lys Ile Pro Arg Trp Asp Leu Ser Lys Phe Leu Arg Val Ser 
            740                 745                 750         


Thr Lys Ile Gly Ser Cys Met Lys Ser Val Gly Glu Val Met Gly Ile 
        755                 760                 765             


Gly Arg Ser Phe Glu Glu Ala Phe Gln Lys Ala Leu Arg Met Val Asp 
    770                 775                 780                 


Glu Asn Cys Val Gly Phe Asp His Thr Val Lys Pro Val Ser Asp Met 
785                 790                 795                 800 


Glu Leu Glu Thr Pro Thr Asp Lys Arg Ile Phe Val Val Ala Ala Ala 
                805                 810                 815     


Leu Trp Ala Gly Tyr Ser Val Asp Arg Leu Tyr Glu Leu Thr Arg Ile 
            820                 825                 830         


Asp Arg Trp Phe Leu His Arg Met Lys Arg Ile Ile Ala His Ala Gln 
        835                 840                 845             


Leu Leu Glu Gln His Arg Gly Gln Pro Leu Pro Pro Asp Leu Leu Gln 
    850                 855                 860                 


Gln Ala Lys Cys Leu Gly Phe Ser Asp Lys Gln Ile Ala Leu Ala Val 
865                 870                 875                 880 


Leu Ser Thr Glu Leu Ala Val Arg Lys Leu Arg Gln Glu Leu Gly Ile 
                885                 890                 895     


Cys Pro Ala Val Lys Gln Ile Asp Thr Val Ala Ala Glu Trp Pro Ala 
            900                 905                 910         


Gln Thr Asn Tyr Leu Tyr Leu Thr Tyr Trp Gly Thr Thr His Asp Leu 
        915                 920                 925             


Thr Phe Arg Thr Pro His Val Leu Val Leu Gly Ser Gly Val Tyr Arg 
    930                 935                 940                 


Ile Gly Ser Ser Val Glu Phe Asp Trp Cys Ala Val Gly Cys Ile Gln 
945                 950                 955                 960 


Gln Leu Arg Lys Met Gly Tyr Lys Thr Ile Met Val Asn Tyr Asn Pro 
                965                 970                 975     


Glu Thr Val Ser Thr Asp Tyr Asp Met Cys Asp Arg Leu Tyr Phe Asp 
            980                 985                 990         


Glu Ile Ser Phe Glu Val Val Met  Asp Ile Tyr Glu Leu  Glu Asn Pro 
        995                 1000                 1005             


Glu Gly  Val Ile Leu Ser Met  Gly Gly Gln Leu Pro  Asn Asn Met 
    1010                 1015                 1020             


Ala Met  Ala Leu His Arg Gln  Gln Cys Arg Val Leu  Gly Thr Ser 
    1025                 1030                 1035             


Pro Glu  Ala Ile Asp Ser Ala  Glu Asn Arg Phe Lys  Phe Ser Arg 
    1040                 1045                 1050             


Leu Leu  Asp Thr Ile Gly Ile  Ser Gln Pro Gln Trp  Arg Glu Leu 
    1055                 1060                 1065             


Ser Asp  Leu Glu Ser Ala Arg  Gln Phe Cys Gln Thr  Val Gly Tyr 
    1070                 1075                 1080             


Pro Cys  Val Val Arg Pro Ser  Tyr Val Leu Ser Gly  Ala Ala Met 
    1085                 1090                 1095             


Asn Val  Ala Tyr Thr Asp Gly  Asp Leu Glu Arg Phe  Leu Ser Ser 
    1100                 1105                 1110             


Ala Ala  Ala Val Ser Lys Glu  His Pro Val Val Ile  Ser Lys Phe 
    1115                 1120                 1125             


Ile Gln  Glu Ala Lys Glu Ile  Asp Val Asp Ala Val  Ala Ser Asp 
    1130                 1135                 1140             


Gly Val  Val Ala Ala Ile Ala  Ile Ser Glu His Val  Glu Asn Ala 
    1145                 1150                 1155             


Gly Val  His Ser Gly Asp Ala  Thr Leu Val Thr Pro  Pro Gln Asp 
    1160                 1165                 1170             


Ile Thr  Ala Lys Thr Leu Glu  Arg Ile Lys Ala Ile  Val His Ala 
    1175                 1180                 1185             


Val Gly  Gln Glu Leu Gln Val  Thr Gly Pro Phe Asn  Leu Gln Leu 
    1190                 1195                 1200             


Ile Ala  Lys Asp Asp Gln Leu  Lys Val Ile Glu Cys  Asn Val Arg 
    1205                 1210                 1215             


Val Ser  Arg Ser Phe Pro Phe  Val Ser Lys Thr Leu  Gly Val Asp 
    1220                 1225                 1230             


Leu Val  Ala Leu Ala Thr Arg  Val Ile Met Gly Glu  Glu Val Glu 
    1235                 1240                 1245             


Pro Val  Gly Leu Met Thr Gly  Ser Gly Val Val Gly  Val Lys Val 
    1250                 1255                 1260             


Pro Gln  Phe Ser Phe Ser Arg  Leu Ala Gly Ala Asp  Val Val Leu 
    1265                 1270                 1275             


Gly Val  Glu Met Thr Ser Thr  Gly Glu Val Ala Gly  Phe Gly Glu 
    1280                 1285                 1290             


Ser Arg  Cys Glu Ala Tyr Leu  Lys Ala Met Leu Ser  Thr Gly Phe 
    1295                 1300                 1305             


Lys Ile  Pro Lys Lys Asn Ile  Leu Leu Thr Ile Gly  Ser Tyr Lys 
    1310                 1315                 1320             


Asn Lys  Ser Glu Leu Leu Pro  Thr Val Arg Leu Leu  Glu Ser Leu 
    1325                 1330                 1335             


Gly Tyr  Ser Leu Tyr Ala Ser  Leu Gly Thr Ala Asp  Phe Tyr Thr 
    1340                 1345                 1350             


Glu His  Gly Val Lys Val Thr  Ala Val Asp Trp His  Phe Glu Glu 
    1355                 1360                 1365             


Ala Val  Asp Gly Glu Cys Pro  Pro Gln Arg Ser Ile  Leu Glu Gln 
    1370                 1375                 1380             


Leu Ala  Glu Lys Asn Phe Glu  Leu Val Ile Asn Leu  Ser Met Arg 
    1385                 1390                 1395             


Gly Ala  Gly Gly Arg Arg Leu  Ser Ser Phe Val Thr  Lys Gly Tyr 
    1400                 1405                 1410             


Arg Thr  Arg Arg Leu Ala Ala  Asp Phe Ser Val Pro  Leu Ile Ile 
    1415                 1420                 1425             


Asp Ile  Lys Cys Thr Lys Leu  Phe Val Glu Ala Leu  Gly Gln Ile 
    1430                 1435                 1440             


Gly Pro  Ala Pro Pro Leu Lys  Val His Val Asp Cys  Met Thr Ser 
    1445                 1450                 1455             


Gln Lys  Leu Val Arg Leu Pro  Gly Leu Ile Asp Val  His Val His 
    1460                 1465                 1470             


Leu Arg  Glu Pro Gly Gly Thr  His Lys Glu Asp Phe  Ala Ser Gly 
    1475                 1480                 1485             


Thr Ala  Ala Ala Leu Ala Gly  Gly Ile Thr Met Val  Cys Ala Met 
    1490                 1495                 1500             


Pro Asn  Thr Arg Pro Pro Ile  Ile Asp Ala Pro Ala  Leu Ala Leu 
    1505                 1510                 1515             


Ala Gln  Lys Leu Ala Glu Ala  Gly Ala Arg Cys Asp  Phe Ala Leu 
    1520                 1525                 1530             


Phe Leu  Gly Ala Ser Ser Glu  Asn Ala Gly Thr Leu  Gly Thr Val 
    1535                 1540                 1545             


Ala Gly  Ser Ala Ala Gly Leu  Lys Leu Tyr Leu Asn  Glu Thr Phe 
    1550                 1555                 1560             


Ser Glu  Leu Arg Leu Asp Ser  Val Val Gln Trp Met  Glu His Phe 
    1565                 1570                 1575             


Glu Thr  Trp Pro Ser His Leu  Pro Ile Val Ala His  Ala Glu Gln 
    1580                 1585                 1590             


Gln Thr  Val Ala Ala Val Leu  Met Val Ala Gln Leu  Thr Gln Arg 
    1595                 1600                 1605             


Ser Val  His Ile Cys His Val  Ala Arg Lys Glu Glu  Ile Leu Leu 
    1610                 1615                 1620             


Ile Lys  Ala Ala Lys Ala Arg  Gly Leu Pro Val Thr  Cys Glu Val 
    1625                 1630                 1635             


Ala Pro  His His Leu Phe Leu  Ser His Asp Asp Leu  Glu Arg Leu 
    1640                 1645                 1650             


Gly Pro  Gly Lys Gly Glu Val  Arg Pro Glu Leu Gly  Ser Arg Gln 
    1655                 1660                 1665             


Asp Val  Glu Ala Leu Trp Glu  Asn Met Ala Val Ile  Asp Cys Phe 
    1670                 1675                 1680             


Ala Ser  Asp His Ala Pro His  Thr Leu Glu Glu Lys  Cys Gly Ser 
    1685                 1690                 1695             


Arg Pro  Pro Pro Gly Phe Pro  Gly Leu Glu Thr Met  Leu Pro Leu 
    1700                 1705                 1710             


Leu Leu  Thr Ala Val Ser Glu  Gly Arg Leu Ser Leu  Asp Asp Leu 
    1715                 1720                 1725             


Leu Gln  Arg Leu His His Asn  Pro Arg Arg Ile Phe  His Leu Pro 
    1730                 1735                 1740             


Pro Gln  Glu Asp Thr Tyr Val  Glu Val Asp Leu Glu  His Glu Trp 
    1745                 1750                 1755             


Thr Ile  Pro Ser His Met Pro  Phe Ser Lys Ala His  Trp Thr Pro 
    1760                 1765                 1770             


Phe Glu  Gly Gln Lys Val Lys  Gly Thr Val Arg Arg  Val Val Leu 
    1775                 1780                 1785             


Arg Gly  Glu Val Ala Tyr Ile  Asp Gly Gln Val Leu  Val Pro Pro 
    1790                 1795                 1800             


Gly Tyr  Gly Gln Asp Val Arg  Lys Trp Pro Gln Gly  Ala Val Pro 
    1805                 1810                 1815             


Gln Leu  Pro Pro Ser Ala Pro  Ala Thr Ser Glu Met  Thr Thr Thr 
    1820                 1825                 1830             


Pro Glu  Arg Pro Arg Arg Gly  Ile Pro Gly Leu Pro  Asp Gly Arg 
    1835                 1840                 1845             


Phe His  Leu Pro Pro Arg Ile  His Arg Ala Ser Asp  Pro Gly Leu 
    1850                 1855                 1860             


Pro Ala  Glu Glu Pro Lys Glu  Lys Ser Ser Arg Lys  Val Ala Glu 
    1865                 1870                 1875             


Pro Glu  Leu Met Gly Thr Pro  Asp Gly Thr Cys Tyr  Pro Pro Pro 
    1880                 1885                 1890             


Pro Val  Pro Arg Gln Ala Ser  Pro Gln Asn Leu Gly  Thr Pro Gly 
    1895                 1900                 1905             


Leu Leu  His Pro Gln Thr Ser  Pro Leu Leu His Ser  Leu Val Gly 
    1910                 1915                 1920             


Gln His  Ile Leu Ser Val Gln  Gln Phe Thr Lys Asp  Gln Met Ser 
    1925                 1930                 1935             


His Leu  Phe Asn Val Ala His  Thr Leu Arg Met Met  Val Gln Lys 
    1940                 1945                 1950             


Glu Arg  Ser Leu Asp Ile Leu  Lys Gly Lys Val Met  Ala Ser Met 
    1955                 1960                 1965             


Phe Tyr  Glu Val Ser Thr Arg  Thr Ser Ser Ser Phe  Ala Ala Ala 
    1970                 1975                 1980             


Met Ala  Arg Leu Gly Gly Ala  Val Leu Ser Phe Ser  Glu Ala Thr 
    1985                 1990                 1995             


Ser Ser  Val Gln Lys Gly Glu  Ser Leu Ala Asp Ser  Val Gln Thr 
    2000                 2005                 2010             


Met Ser  Cys Tyr Ala Asp Val  Val Val Leu Arg His  Pro Gln Pro 
    2015                 2020                 2025             


Gly Ala  Val Glu Leu Ala Ala  Lys His Cys Arg Arg  Pro Val Ile 
    2030                 2035                 2040             


Asn Ala  Gly Asp Gly Val Gly  Glu His Pro Thr Gln  Ala Leu Leu 
    2045                 2050                 2055             


Asp Ile  Phe Thr Ile Arg Glu  Glu Leu Gly Thr Val  Asn Gly Met 
    2060                 2065                 2070             


Thr Ile  Thr Met Val Gly Asp  Leu Lys His Gly Arg  Thr Val His 
    2075                 2080                 2085             


Ser Leu  Ala Cys Leu Leu Thr  Gln Tyr Arg Val Ser  Leu Arg Tyr 
    2090                 2095                 2100             


Val Ala  Pro Pro Ser Leu Arg  Met Pro Pro Thr Val  Arg Ala Phe 
    2105                 2110                 2115             


Val Ala  Ser Arg Gly Thr Lys  Gln Glu Glu Phe Glu  Ser Ile Glu 
    2120                 2125                 2130             


Glu Ala  Leu Pro Asp Thr Asp  Val Leu Tyr Met Thr  Arg Ile Gln 
    2135                 2140                 2145             


Lys Glu  Arg Phe Gly Ser Thr  Gln Glu Tyr Glu Ala  Cys Phe Gly 
    2150                 2155                 2160             


Gln Phe  Ile Leu Thr Pro His  Ile Met Thr Arg Ala  Lys Lys Lys 
    2165                 2170                 2175             


Met Val  Val Met His Pro Met  Pro Arg Val Asn Glu  Ile Ser Val 
    2180                 2185                 2190             


Glu Val  Asp Ser Asp Pro Arg  Ala Ala Tyr Phe Arg  Gln Ala Glu 
    2195                 2200                 2205             


Asn Gly  Met Tyr Ile Arg Met  Ala Leu Leu Ala Thr  Val Leu Gly 
    2210                 2215                 2220             


Arg Phe  
    2225 


<210>  15
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Ser Gly Ile His Val Ala Leu Val Thr Gly Gly Asn Lys Gly 
1               5                   10                  15      


Ile Gly Leu Ala Ile Val Arg Asp Leu Cys Arg Leu Phe Ser Gly Asp 
            20                  25                  30          


Val Val Leu Thr Ala Arg Asp Val Thr Arg Gly Gln Ala Ala Val Gln 
        35                  40                  45              


Gln Leu Gln Ala Glu Gly Leu Ser Pro Arg Phe His Gln Leu Asp Ile 
    50                  55                  60                  


Asp Asp Leu Gln Ser Ile Arg Ala Leu Arg Asp Phe Leu Arg Lys Glu 
65                  70                  75                  80  


Tyr Gly Gly Leu Asp Val Leu Val Asn Asn Ala Gly Ile Ala Phe Lys 
                85                  90                  95      


Val Ala Asp Pro Thr Pro Phe His Ile Gln Ala Glu Val Thr Met Lys 
            100                 105                 110         


Thr Asn Phe Phe Gly Thr Arg Asp Val Cys Thr Glu Leu Leu Pro Leu 
        115                 120                 125             


Ile Lys Pro Gln Gly Arg Val Val Asn Val Ser Ser Ile Met Ser Val 
    130                 135                 140                 


Arg Ala Leu Lys Ser Cys Ser Pro Glu Leu Gln Gln Lys Phe Arg Ser 
145                 150                 155                 160 


Glu Thr Ile Thr Glu Glu Glu Leu Val Gly Leu Met Asn Lys Phe Val 
                165                 170                 175     


Glu Asp Thr Lys Lys Gly Val His Gln Lys Glu Gly Trp Pro Ser Ser 
            180                 185                 190         


Ala Tyr Gly Val Thr Lys Ile Gly Val Thr Val Leu Ser Arg Ile His 
        195                 200                 205             


Ala Arg Lys Leu Ser Glu Gln Arg Lys Gly Asp Lys Ile Leu Leu Asn 
    210                 215                 220                 


Ala Cys Cys Pro Gly Trp Val Arg Thr Asp Met Ala Gly Pro Lys Ala 
225                 230                 235                 240 


Thr Lys Ser Pro Glu Glu Gly Ala Glu Thr Pro Val Tyr Leu Ala Leu 
                245                 250                 255     


Leu Pro Pro Asp Ala Glu Gly Pro His Gly Gln Phe Val Ser Glu Lys 
            260                 265                 270         


Arg Val Glu Gln Trp 
        275         


<210>  16
<211>  4069
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Ser Arg Asp Ser Asn His Ala Gly Glu Ser Phe Leu Gly Ser 
1               5                   10                  15      


Asp Gly Asp Glu Glu Ala Thr Arg Glu Leu Glu Thr Glu Glu Glu Ser 
            20                  25                  30          


Glu Gly Glu Glu Asp Glu Thr Ala Ala Glu Ser Glu Glu Glu Pro Asp 
        35                  40                  45              


Ser Arg Leu Ser Asp Gln Asp Glu Glu Gly Lys Ile Lys Gln Glu Tyr 
    50                  55                  60                  


Ile Ile Ser Asp Pro Ser Phe Ser Met Val Thr Val Gln Arg Glu Asp 
65                  70                  75                  80  


Ser Gly Ile Thr Trp Glu Thr Asn Ser Ser Arg Ser Ser Thr Pro Trp 
                85                  90                  95      


Ala Ser Glu Glu Ser Gln Thr Ser Gly Val Cys Ser Arg Glu Gly Ser 
            100                 105                 110         


Thr Val Asn Ser Pro Pro Gly Asn Val Ser Phe Ile Val Asp Glu Val 
        115                 120                 125             


Lys Lys Val Arg Lys Arg Thr His Lys Ser Lys His Gly Ser Pro Ser 
    130                 135                 140                 


Leu Arg Arg Lys Gly Asn Arg Lys Arg Asn Ser Phe Glu Ser Gln Asp 
145                 150                 155                 160 


Val Pro Thr Asn Lys Lys Gly Ser Pro Leu Thr Ser Ala Ser Gln Val 
                165                 170                 175     


Leu Thr Thr Glu Lys Glu Lys Ser Tyr Thr Gly Ile Tyr Asp Lys Ala 
            180                 185                 190         


Arg Lys Lys Lys Thr Thr Ser Asn Thr Pro Pro Ile Thr Gly Ala Ile 
        195                 200                 205             


Tyr Lys Glu His Lys Pro Leu Val Leu Arg Pro Val Tyr Ile Gly Thr 
    210                 215                 220                 


Val Gln Tyr Lys Ile Lys Met Phe Asn Ser Val Lys Glu Glu Leu Ile 
225                 230                 235                 240 


Pro Leu Gln Phe Tyr Gly Thr Leu Pro Lys Gly Tyr Val Ile Lys Glu 
                245                 250                 255     


Ile His Tyr Arg Lys Gly Lys Asp Ala Ser Ile Ser Leu Glu Pro Asp 
            260                 265                 270         


Leu Asp Asn Ser Gly Ser Asn Thr Val Ser Lys Thr Arg Lys Leu Val 
        275                 280                 285             


Ala Gln Ser Ile Glu Asp Lys Val Lys Glu Val Phe Pro Pro Trp Arg 
    290                 295                 300                 


Gly Ala Leu Ser Lys Gly Ser Glu Ser Leu Thr Leu Met Phe Ser His 
305                 310                 315                 320 


Glu Asp Gln Lys Lys Ile Tyr Ala Asp Ser Pro Leu Asn Ala Thr Ser 
                325                 330                 335     


Ala Leu Glu His Thr Val Pro Ser Tyr Ser Ser Ser Gly Arg Ala Glu 
            340                 345                 350         


Gln Gly Ile Gln Leu Arg His Ser Gln Ser Val Pro Gln Gln Pro Glu 
        355                 360                 365             


Asp Glu Ala Lys Pro His Glu Val Glu Pro Pro Ser Val Thr Pro Asp 
    370                 375                 380                 


Thr Pro Ala Thr Met Phe Leu Arg Thr Thr Lys Glu Glu Cys Glu Leu 
385                 390                 395                 400 


Ala Ser Pro Gly Thr Ala Ala Ser Glu Asn Asp Ser Ser Val Ser Pro 
                405                 410                 415     


Ser Phe Ala Asn Glu Val Lys Lys Glu Asp Val Tyr Ser Ala His His 
            420                 425                 430         


Ser Ile Ser Leu Glu Ala Ala Ser Pro Gly Leu Ala Ala Ser Thr Gln 
        435                 440                 445             


Asp Gly Leu Asp Pro Asp Gln Glu Gln Pro Asp Leu Thr Ser Ile Glu 
    450                 455                 460                 


Arg Ala Glu Pro Val Ser Ala Lys Leu Thr Pro Thr His Pro Ser Val 
465                 470                 475                 480 


Lys Gly Glu Lys Glu Glu Asn Met Leu Glu Pro Ser Ile Ser Leu Ser 
                485                 490                 495     


Glu Pro Leu Met Leu Glu Glu Pro Glu Lys Glu Glu Ile Glu Thr Ser 
            500                 505                 510         


Leu Pro Ile Ala Ile Thr Pro Glu Pro Glu Asp Ser Asn Leu Val Glu 
        515                 520                 525             


Glu Glu Ile Val Glu Leu Asp Tyr Pro Glu Ser Pro Leu Val Ser Glu 
    530                 535                 540                 


Lys Pro Phe Pro Pro His Met Ser Pro Glu Val Glu His Lys Glu Glu 
545                 550                 555                 560 


Glu Leu Ile Leu Pro Leu Leu Ala Ala Ser Ser Pro Glu His Val Ala 
                565                 570                 575     


Leu Ser Glu Glu Glu Arg Glu Glu Ile Ala Ser Val Ser Thr Gly Ser 
            580                 585                 590         


Ala Phe Val Ser Glu Tyr Ser Val Pro Gln Asp Leu Asn His Glu Leu 
        595                 600                 605             


Gln Glu Gln Glu Gly Glu Pro Val Pro Pro Ser Asn Val Glu Ala Ile 
    610                 615                 620                 


Ala Glu His Ala Val Leu Ser Glu Glu Glu Asn Glu Glu Phe Glu Ala 
625                 630                 635                 640 


Tyr Ser Pro Ala Ala Ala Pro Thr Ser Glu Ser Ser Leu Ser Pro Ser 
                645                 650                 655     


Thr Thr Glu Lys Thr Ser Glu Asn Gln Ser Pro Leu Phe Ser Thr Val 
            660                 665                 670         


Thr Pro Glu Tyr Met Val Leu Ser Gly Asp Glu Ala Ser Glu Ser Gly 
        675                 680                 685             


Cys Tyr Thr Pro Asp Ser Thr Ser Ala Ser Glu Tyr Ser Val Pro Ser 
    690                 695                 700                 


Leu Ala Thr Lys Glu Ser Leu Lys Lys Thr Ile Asp Arg Lys Ser Pro 
705                 710                 715                 720 


Leu Ile Leu Lys Gly Val Ser Glu Tyr Met Ile Pro Ser Glu Glu Lys 
                725                 730                 735     


Glu Asp Thr Gly Ser Phe Thr Pro Ala Val Ala Pro Ala Ser Glu Pro 
            740                 745                 750         


Ser Leu Ser Pro Ser Thr Thr Glu Lys Thr Ser Glu Cys Gln Ser Pro 
        755                 760                 765             


Leu Pro Ser Thr Ala Thr Ser Glu His Val Val Pro Ser Glu Gly Glu 
    770                 775                 780                 


Asp Leu Gly Ser Glu Arg Phe Thr Pro Asp Ser Lys Leu Ile Ser Lys 
785                 790                 795                 800 


Tyr Ala Ala Pro Leu Asn Ala Thr Gln Glu Ser Gln Lys Lys Ile Ile 
                805                 810                 815     


Asn Glu Ala Ser Gln Phe Lys Pro Lys Gly Ile Ser Glu His Thr Val 
            820                 825                 830         


Leu Ser Val Asp Gly Lys Glu Val Ile Gly Pro Ser Ser Pro Asp Leu 
        835                 840                 845             


Val Val Ala Ser Glu His Ser Phe Pro Pro His Thr Thr Glu Met Thr 
    850                 855                 860                 


Ser Glu Cys Gln Ala Pro Pro Leu Ser Ala Thr Pro Ser Glu Tyr Val 
865                 870                 875                 880 


Val Leu Ser Asp Glu Glu Ala Val Glu Leu Glu Arg Tyr Thr Pro Ser 
                885                 890                 895     


Ser Thr Ser Ala Ser Glu Phe Ser Val Pro Pro Tyr Ala Thr Pro Glu 
            900                 905                 910         


Ala Gln Glu Glu Glu Ile Val His Arg Ser Leu Asn Leu Lys Gly Ala 
        915                 920                 925             


Ser Ser Pro Met Asn Leu Ser Glu Glu Asp Gln Glu Asp Ile Gly Pro 
    930                 935                 940                 


Phe Ser Pro Asp Ser Ala Phe Val Ser Glu Phe Ser Phe Pro Pro Tyr 
945                 950                 955                 960 


Ala Thr Gln Glu Ala Glu Lys Arg Glu Phe Glu Cys Asp Ser Pro Ile 
                965                 970                 975     


Cys Leu Thr Ser Pro Ser Glu His Thr Ile Leu Ser Asp Glu Asp Thr 
            980                 985                 990         


Glu Glu Ala Glu Leu Phe Ser Pro  Asp Ser Ala Ser Gln  Val Ser Ile 
        995                 1000                 1005             


Pro Pro  Phe Arg Ile Ser Glu  Thr Glu Lys Asn Glu  Leu Glu Pro 
    1010                 1015                 1020             


Asp Ser  Leu Leu Thr Ala Val  Ser Ala Ser Gly Tyr  Ser Cys Phe 
    1025                 1030                 1035             


Ser Glu  Ala Asp Glu Glu Asp  Ile Gly Ser Thr Ala  Ala Thr Pro 
    1040                 1045                 1050             


Val Ser  Glu Gln Phe Ser Ser  Ser Gln Lys Gln Lys  Ala Glu Thr 
    1055                 1060                 1065             


Phe Pro  Leu Met Ser Pro Leu  Glu Asp Leu Ser Leu  Pro Pro Ser 
    1070                 1075                 1080             


Thr Asp  Lys Ser Glu Lys Ala  Glu Ile Lys Pro Glu  Ile Pro Thr 
    1085                 1090                 1095             


Thr Ser  Thr Ser Val Ser Glu  Tyr Leu Ile Leu Ala  Gln Lys Gln 
    1100                 1105                 1110             


Lys Thr  Gln Ala Tyr Leu Glu  Pro Glu Ser Glu Asp  Leu Ile Pro 
    1115                 1120                 1125             


Ser His  Leu Thr Ser Glu Val  Glu Lys Gly Glu Arg  Glu Ala Ser 
    1130                 1135                 1140             


Ser Ser  Val Ala Ala Ile Pro  Ala Ala Leu Pro Ala  Gln Ser Ser 
    1145                 1150                 1155             


Ile Val  Lys Glu Glu Thr Lys  Pro Ala Ser Pro His  Ser Val Leu 
    1160                 1165                 1170             


Pro Asp  Ser Val Pro Ala Ile  Lys Lys Glu Gln Glu  Pro Thr Ala 
    1175                 1180                 1185             


Ala Leu  Thr Leu Lys Ala Ala  Asp Glu Gln Met Ala  Leu Ser Lys 
    1190                 1195                 1200             


Val Arg  Lys Glu Glu Ile Val  Pro Asp Ser Gln Glu  Ala Thr Ala 
    1205                 1210                 1215             


His Val  Ser Gln Asp Gln Lys  Met Glu Pro Gln Pro  Pro Asn Val 
    1220                 1225                 1230             


Pro Glu  Ser Glu Met Lys Tyr  Ser Val Leu Pro Asp  Met Val Asp 
    1235                 1240                 1245             


Glu Pro  Lys Lys Gly Val Lys  Pro Lys Leu Val Leu  Asn Val Thr 
    1250                 1255                 1260             


Ser Glu  Leu Glu Gln Arg Lys  Leu Ser Lys Asn Glu  Pro Glu Val 
    1265                 1270                 1275             


Ile Lys  Pro Tyr Ser Pro Leu  Lys Glu Thr Ser Leu  Ser Gly Pro 
    1280                 1285                 1290             


Glu Ala  Leu Ser Ala Val Lys  Met Glu Met Lys His  Asp Ser Lys 
    1295                 1300                 1305             


Ile Thr  Thr Thr Pro Ile Val  Leu His Ser Ala Ser  Ser Gly Val 
    1310                 1315                 1320             


Glu Lys  Gln Val Glu His Gly  Pro Pro Ala Leu Ala  Phe Ser Ala 
    1325                 1330                 1335             


Leu Ser  Glu Glu Ile Lys Lys  Glu Ile Glu Pro Ser  Ser Ser Thr 
    1340                 1345                 1350             


Thr Thr  Ala Ser Val Thr Lys  Leu Asp Ser Asn Leu  Thr Arg Ala 
    1355                 1360                 1365             


Val Lys  Glu Glu Ile Pro Thr  Asp Ser Ser Leu Ile  Thr Pro Val 
    1370                 1375                 1380             


Asp Arg  Pro Val Leu Thr Lys  Val Gly Lys Gly Glu  Leu Gly Ser 
    1385                 1390                 1395             


Gly Leu  Pro Pro Leu Val Thr  Ser Ala Asp Glu His  Ser Val Leu 
    1400                 1405                 1410             


Ala Glu  Glu Asp Lys Val Ala  Ile Lys Gly Ala Ser  Pro Ile Glu 
    1415                 1420                 1425             


Thr Ser  Ser Lys His Leu Ala  Trp Ser Glu Ala Glu  Lys Glu Ile 
    1430                 1435                 1440             


Lys Phe  Asp Ser Leu Pro Ser  Val Ser Ser Ile Ala  Glu His Ser 
    1445                 1450                 1455             


Val Leu  Ser Glu Val Glu Ala  Lys Glu Val Lys Ala  Gly Leu Pro 
    1460                 1465                 1470             


Val Ile  Lys Thr Ser Ser Ser  Gln His Ser Asp Lys  Ser Glu Glu 
    1475                 1480                 1485             


Ala Arg  Val Glu Asp Lys Gln  Asp Leu Leu Phe Ser  Thr Val Cys 
    1490                 1495                 1500             


Asp Ser  Glu Arg Leu Val Ser  Ser Gln Lys Lys Ser  Leu Met Ser 
    1505                 1510                 1515             


Thr Ser  Glu Val Leu Glu Pro  Glu His Glu Leu Pro  Leu Ser Leu 
    1520                 1525                 1530             


Trp Gly  Glu Ile Lys Lys Lys  Glu Thr Glu Leu Pro  Ser Ser Gln 
    1535                 1540                 1545             


Asn Val  Ser Pro Ala Ser Lys  His Ile Ile Pro Lys  Gly Lys Asp 
    1550                 1555                 1560             


Glu Glu  Thr Ala Ser Ser Ser  Pro Glu Leu Glu Asn  Leu Ala Ser 
    1565                 1570                 1575             


Gly Leu  Ala Pro Thr Leu Leu  Leu Leu Ser Asp Asp  Lys Asn Lys 
    1580                 1585                 1590             


Pro Ala  Val Glu Val Ser Ser  Thr Ala Gln Gly Asp  Phe Pro Ser 
    1595                 1600                 1605             


Glu Lys  Gln Asp Val Ala Leu  Ala Glu Leu Ser Leu  Glu Pro Glu 
    1610                 1615                 1620             


Lys Lys  Asp Lys Pro His Gln  Pro Leu Glu Leu Pro  Asn Ala Gly 
    1625                 1630                 1635             


Ser Glu  Phe Ser Ser Asp Leu  Gly Arg Gln Ser Gly  Ser Ile Gly 
    1640                 1645                 1650             


Thr Lys  Gln Ala Lys Ser Pro  Ile Thr Glu Thr Glu  Asp Ser Val 
    1655                 1660                 1665             


Leu Glu  Lys Gly Pro Ala Glu  Leu Arg Ser Arg Glu  Gly Lys Glu 
    1670                 1675                 1680             


Glu Asn  Arg Glu Leu Cys Ala  Ser Ser Thr Met Pro  Ala Ile Ser 
    1685                 1690                 1695             


Glu Leu  Ser Ser Leu Leu Arg  Glu Glu Ser Gln Asn  Glu Glu Ile 
    1700                 1705                 1710             


Lys Pro  Phe Ser Pro Lys Ile  Ile Ser Leu Glu Ser  Lys Glu Pro 
    1715                 1720                 1725             


Pro Ala  Ser Val Ala Glu Gly  Gly Asn Pro Glu Glu  Phe Gln Pro 
    1730                 1735                 1740             


Phe Thr  Phe Ser Leu Lys Gly  Leu Ser Glu Glu Val  Ser His Pro 
    1745                 1750                 1755             


Ala Asp  Phe Lys Lys Gly Gly  Asn Gln Glu Ile Gly  Pro Leu Pro 
    1760                 1765                 1770             


Pro Thr  Gly Asn Leu Lys Ala  Gln Val Met Gly Asp  Ile Leu Asp 
    1775                 1780                 1785             


Lys Leu  Ser Glu Glu Thr Gly  His Pro Asn Ser Ser  Gln Val Leu 
    1790                 1795                 1800             


Gln Ser  Ile Thr Glu Pro Ser  Lys Ile Ala Pro Ser  Asp Leu Leu 
    1805                 1810                 1815             


Val Glu  Gln Lys Lys Thr Glu  Lys Ala Leu His Ser  Asp Gln Thr 
    1820                 1825                 1830             


Val Lys  Leu Pro Asp Val Ser  Thr Ser Ser Glu Asp  Lys Gln Asp 
    1835                 1840                 1845             


Leu Gly  Ile Lys Gln Phe Ser  Leu Met Arg Glu Asn  Leu Pro Leu 
    1850                 1855                 1860             


Glu Gln  Ser Lys Ser Phe Met  Thr Thr Lys Pro Ala  Asp Val Lys 
    1865                 1870                 1875             


Glu Thr  Lys Met Glu Glu Phe  Phe Ile Ser Pro Lys  Asp Glu Asn 
    1880                 1885                 1890             


Trp Met  Leu Gly Lys Pro Glu  Asn Val Ala Ser Gln  His Glu Gln 
    1895                 1900                 1905             


Arg Ile  Ala Gly Ser Val Gln  Leu Asp Ser Ser Ser  Ser Asn Glu 
    1910                 1915                 1920             


Leu Arg  Pro Gly Gln Leu Lys  Ala Ala Val Ser Ser  Lys Asp His 
    1925                 1930                 1935             


Thr Cys  Glu Val Arg Lys Gln  Val Leu Pro His Ser  Ala Glu Glu 
    1940                 1945                 1950             


Ser His  Leu Ser Ser Gln Glu  Ala Val Ser Ala Leu  Asp Thr Ser 
    1955                 1960                 1965             


Ser Gly  Asn Thr Glu Thr Leu  Ser Ser Lys Ser Tyr  Ser Ser Glu 
    1970                 1975                 1980             


Glu Val  Lys Leu Ala Glu Glu  Pro Lys Ser Leu Val  Leu Ala Gly 
    1985                 1990                 1995             


Asn Val  Glu Arg Asn Ile Ala  Glu Gly Lys Glu Ile  His Ser Leu 
    2000                 2005                 2010             


Met Glu  Ser Glu Ser Leu Leu  Leu Glu Lys Ala Asn  Thr Glu Leu 
    2015                 2020                 2025             


Ser Trp  Pro Ser Lys Glu Asp  Ser Gln Glu Lys Ile  Lys Leu Pro 
    2030                 2035                 2040             


Pro Glu  Arg Phe Phe Gln Lys  Pro Val Ser Gly Leu  Ser Val Glu 
    2045                 2050                 2055             


Gln Val  Lys Ser Glu Thr Ile  Ser Ser Ser Val Lys  Thr Ala His 
    2060                 2065                 2070             


Phe Pro  Ala Glu Gly Val Glu  Pro Ala Leu Gly Asn  Glu Lys Glu 
    2075                 2080                 2085             


Ala His  Arg Ser Thr Pro Pro  Phe Pro Glu Glu Lys  Pro Leu Glu 
    2090                 2095                 2100             


Glu Ser  Lys Met Val Gln Ser  Lys Val Ile Asp Asp  Ala Asp Glu 
    2105                 2110                 2115             


Gly Lys  Lys Pro Ser Pro Glu  Val Lys Ile Pro Thr  Gln Arg Lys 
    2120                 2125                 2130             


Pro Ile  Ser Ser Ile His Ala  Arg Glu Pro Gln Ser  Pro Glu Ser 
    2135                 2140                 2145             


Pro Glu  Val Thr Gln Asn Pro  Pro Thr Gln Pro Lys  Val Ala Lys 
    2150                 2155                 2160             


Pro Asp  Leu Pro Glu Glu Lys  Gly Lys Lys Gly Ile  Ser Ser Phe 
    2165                 2170                 2175             


Lys Ser  Trp Met Ser Ser Leu  Phe Phe Gly Ser Ser  Thr Pro Asp 
    2180                 2185                 2190             


Asn Lys  Val Ala Glu Gln Glu  Asp Leu Glu Thr Gln  Pro Ser Pro 
    2195                 2200                 2205             


Ser Val  Glu Lys Ala Val Thr  Val Ile Asp Pro Glu  Gly Thr Ile 
    2210                 2215                 2220             


Pro Thr  Asn Phe Asn Val Ala  Glu Lys Pro Ala Asp  His Ser Leu 
    2225                 2230                 2235             


Ser Glu  Val Lys Leu Lys Thr  Ala Asp Glu Pro Arg  Gly Thr Leu 
    2240                 2245                 2250             


Val Lys  Ser Gly Asp Gly Gln  Asn Val Lys Glu Lys  Ser Met Ile 
    2255                 2260                 2265             


Leu Ser  Asn Val Glu Asp Leu  Gln Gln Pro Lys Phe  Ile Ser Glu 
    2270                 2275                 2280             


Val Ser  Arg Glu Asp Tyr Gly  Lys Lys Glu Ile Ser  Gly Asp Ser 
    2285                 2290                 2295             


Glu Glu  Met Asn Ile Asn Ser  Val Val Thr Ser Ala  Asp Gly Glu 
    2300                 2305                 2310             


Asn Leu  Glu Ile Gln Ser Tyr  Ser Leu Ile Gly Glu  Lys Leu Val 
    2315                 2320                 2325             


Met Glu  Glu Ala Lys Thr Ile  Val Pro Pro His Val  Thr Asp Ser 
    2330                 2335                 2340             


Lys Arg  Val Gln Lys Pro Ala  Ile Ala Pro Pro Ser  Lys Trp Asn 
    2345                 2350                 2355             


Ile Ser  Ile Phe Lys Glu Glu  Pro Arg Ser Asp Gln  Lys Gln Lys 
    2360                 2365                 2370             


Ser Leu  Leu Ser Phe Asp Val  Val Asp Lys Val Pro  Gln Gln Pro 
    2375                 2380                 2385             


Lys Ser  Ala Ser Ser Asn Phe  Ala Ser Lys Asn Ile  Thr Lys Glu 
    2390                 2395                 2400             


Ser Glu  Lys Pro Glu Ser Ile  Ile Leu Pro Val Glu  Glu Ser Lys 
    2405                 2410                 2415             


Gly Ser  Leu Ile Asp Phe Ser  Glu Asp Arg Leu Lys  Lys Glu Met 
    2420                 2425                 2430             


Gln Asn  Pro Thr Ser Leu Lys  Ile Ser Glu Glu Glu  Thr Lys Leu 
    2435                 2440                 2445             


Arg Ser  Val Ser Pro Thr Glu  Lys Lys Asp Asn Leu  Glu Asn Arg 
    2450                 2455                 2460             


Ser Tyr  Thr Leu Ala Glu Lys  Lys Val Leu Ala Glu  Lys Gln Asn 
    2465                 2470                 2475             


Ser Val  Ala Pro Leu Glu Leu  Arg Asp Ser Asn Glu  Ile Gly Lys 
    2480                 2485                 2490             


Thr Gln  Ile Thr Leu Gly Ser  Arg Ser Thr Glu Leu  Lys Glu Ser 
    2495                 2500                 2505             


Lys Ala  Asp Ala Met Pro Gln  His Phe Tyr Gln Asn  Glu Asp Tyr 
    2510                 2515                 2520             


Asn Glu  Arg Pro Lys Ile Ile  Val Gly Ser Glu Lys  Glu Lys Gly 
    2525                 2530                 2535             


Glu Glu  Lys Glu Asn Gln Val  Tyr Val Leu Ser Glu  Gly Lys Lys 
    2540                 2545                 2550             


Gln Gln  Glu His Gln Pro Tyr  Ser Val Asn Val Ala  Glu Ser Met 
    2555                 2560                 2565             


Ser Arg  Glu Ser Asp Ile Ser  Leu Gly His Ser Leu  Gly Glu Thr 
    2570                 2575                 2580             


Gln Ser  Phe Ser Leu Val Lys  Ala Thr Ser Val Thr  Glu Lys Ser 
    2585                 2590                 2595             


Glu Ala  Met Leu Ala Glu Ala  His Pro Glu Ile Arg  Glu Ala Lys 
    2600                 2605                 2610             


Ala Val  Gly Thr Gln Pro His  Pro Leu Glu Glu Ser  Lys Val Leu 
    2615                 2620                 2625             


Val Glu  Lys Thr Lys Thr Phe  Leu Pro Val Ala Leu  Ser Cys Arg 
    2630                 2635                 2640             


Asp Glu  Ile Glu Asn His Ser  Leu Ser Gln Glu Gly  Asn Leu Val 
    2645                 2650                 2655             


Leu Glu  Lys Ser Ser Arg Asp  Met Pro Asp His Ser  Glu Glu Lys 
    2660                 2665                 2670             


Glu Gln  Phe Arg Glu Ser Glu  Leu Ser Lys Gly Gly  Ser Val Asp 
    2675                 2680                 2685             


Ile Thr  Lys Glu Thr Val Lys  Gln Gly Phe Gln Glu  Lys Ala Val 
    2690                 2695                 2700             


Gly Thr  Gln Pro Arg Pro Leu  Glu Glu Ser Lys Val  Leu Val Glu 
    2705                 2710                 2715             


Lys Thr  Lys Thr Phe Leu Pro  Val Val Leu Ser Cys  His Asp Glu 
    2720                 2725                 2730             


Ile Glu  Asn His Ser Leu Ser  Gln Glu Gly Asn Leu  Val Leu Glu 
    2735                 2740                 2745             


Lys Ser  Ser Arg Asp Met Pro  Asp His Ser Glu Glu  Lys Glu Gln 
    2750                 2755                 2760             


Phe Lys  Glu Ser Glu Leu Trp  Lys Gly Gly Ser Val  Asp Ile Thr 
    2765                 2770                 2775             


Lys Glu  Ser Met Lys Glu Gly  Phe Pro Ser Lys Glu  Ser Glu Arg 
    2780                 2785                 2790             


Thr Leu  Ala Arg Pro Phe Asp  Glu Thr Lys Ser Ser  Glu Thr Pro 
    2795                 2800                 2805             


Pro Tyr  Leu Leu Ser Pro Val  Lys Pro Gln Thr Leu  Ala Ser Gly 
    2810                 2815                 2820             


Ala Ser  Pro Glu Ile Asn Ala  Val Lys Lys Lys Glu  Met Pro Arg 
    2825                 2830                 2835             


Ser Glu  Leu Thr Pro Glu Arg  His Thr Val His Thr  Ile Gln Thr 
    2840                 2845                 2850             


Ser Lys  Asp Asp Thr Ser Asp  Val Pro Lys Gln Ser  Val Leu Val 
    2855                 2860                 2865             


Ser Lys  His His Leu Glu Ala  Ala Glu Asp Thr Arg  Val Lys Glu 
    2870                 2875                 2880             


Pro Leu  Ser Ser Ala Lys Ser  Asn Tyr Ala Gln Phe  Ile Ser Asn 
    2885                 2890                 2895             


Thr Ser  Ala Ser Asn Ala Asp  Lys Met Val Ser Asn  Lys Glu Met 
    2900                 2905                 2910             


Pro Lys  Glu Pro Glu Asp Thr  Tyr Ala Lys Gly Glu  Asp Phe Thr 
    2915                 2920                 2925             


Val Thr  Ser Lys Pro Ala Gly  Leu Ser Glu Asp Gln  Lys Thr Ala 
    2930                 2935                 2940             


Phe Ser  Ile Ile Ser Glu Gly  Cys Glu Ile Leu Asn  Ile His Ala 
    2945                 2950                 2955             


Pro Ala  Phe Ile Ser Ser Ile  Asp Gln Glu Glu Ser  Glu Gln Met 
    2960                 2965                 2970             


Gln Asp  Lys Leu Glu Tyr Leu  Glu Glu Lys Ala Ser  Phe Lys Thr 
    2975                 2980                 2985             


Ile Pro  Leu Pro Asp Asp Ser  Glu Thr Val Ala Cys  His Lys Thr 
    2990                 2995                 3000             


Leu Lys  Ser Arg Leu Glu Asp  Glu Lys Val Thr Pro  Leu Lys Glu 
    3005                 3010                 3015             


Asn Lys  Gln Lys Glu Thr His  Lys Thr Lys Glu Glu  Ile Ser Thr 
    3020                 3025                 3030             


Asp Ser  Glu Thr Asp Leu Ser  Phe Ile Gln Pro Thr  Ile Pro Ser 
    3035                 3040                 3045             


Glu Glu  Asp Tyr Phe Glu Lys  Tyr Thr Leu Ile Asp  Tyr Asn Ile 
    3050                 3055                 3060             


Ser Pro  Asp Pro Glu Lys Gln  Lys Ala Pro Gln Lys  Leu Asn Val 
    3065                 3070                 3075             


Glu Glu  Lys Leu Ser Lys Glu  Val Thr Glu Glu Thr  Ile Ser Phe 
    3080                 3085                 3090             


Pro Val  Ser Ser Val Glu Ser  Ala Leu Glu His Glu  Tyr Asp Leu 
    3095                 3100                 3105             


Val Lys  Leu Asp Glu Ser Phe  Tyr Gly Pro Glu Lys  Gly His Asn 
    3110                 3115                 3120             


Ile Leu  Ser His Pro Glu Thr  Gln Ser Gln Asn Ser  Ala Asp Arg 
    3125                 3130                 3135             


Asn Val  Ser Lys Asp Thr Lys  Arg Asp Val Asp Ser  Lys Ser Pro 
    3140                 3145                 3150             


Gly Met  Pro Leu Phe Glu Ala  Glu Glu Gly Val Leu  Ser Arg Thr 
    3155                 3160                 3165             


Gln Ile  Phe Pro Thr Thr Ile  Lys Val Ile Asp Pro  Glu Phe Leu 
    3170                 3175                 3180             


Glu Glu  Pro Pro Ala Leu Ala  Phe Leu Tyr Lys Asp  Leu Tyr Glu 
    3185                 3190                 3195             


Glu Ala  Val Gly Glu Lys Lys  Lys Glu Glu Glu Thr  Ala Ser Glu 
    3200                 3205                 3210             


Gly Asp  Ser Val Asn Ser Glu  Ala Ser Phe Pro Ser  Arg Asn Ser 
    3215                 3220                 3225             


Asp Thr  Asp Asp Gly Thr Gly  Ile Tyr Phe Glu Lys  Tyr Ile Leu 
    3230                 3235                 3240             


Lys Asp  Asp Ile Leu His Asp  Thr Ser Leu Thr Gln  Lys Asp Gln 
    3245                 3250                 3255             


Gly Gln  Gly Leu Glu Glu Lys  Arg Val Gly Lys Asp  Asp Ser Tyr 
    3260                 3265                 3270             


Gln Pro  Ile Ala Ala Glu Gly  Glu Ile Trp Gly Lys  Phe Gly Thr 
    3275                 3280                 3285             


Ile Cys  Arg Glu Lys Ser Leu  Glu Glu Gln Lys Gly  Val Tyr Gly 
    3290                 3295                 3300             


Glu Gly  Glu Ser Val Asp His  Val Glu Thr Val Gly  Asn Val Ala 
    3305                 3310                 3315             


Met Gln  Lys Lys Ala Pro Ile  Thr Glu Asp Val Arg  Val Ala Thr 
    3320                 3325                 3330             


Gln Lys  Ile Ser Tyr Ala Val  Pro Phe Glu Asp Thr  His His Val 
    3335                 3340                 3345             


Leu Glu  Arg Ala Asp Glu Ala  Gly Ser His Gly Asn  Glu Val Gly 
    3350                 3355                 3360             


Asn Ala  Ser Pro Glu Val Asn  Leu Asn Val Pro Val  Gln Val Ser 
    3365                 3370                 3375             


Phe Pro  Glu Glu Glu Phe Ala  Ser Gly Ala Thr His  Val Gln Glu 
    3380                 3385                 3390             


Thr Ser  Leu Glu Glu Pro Lys  Ile Leu Val Pro Pro  Glu Pro Ser 
    3395                 3400                 3405             


Glu Glu  Arg Leu Arg Asn Ser  Pro Val Gln Asp Glu  Tyr Glu Phe 
    3410                 3415                 3420             


Thr Glu  Ser Leu His Asn Glu  Val Val Pro Gln Asp  Ile Leu Ser 
    3425                 3430                 3435             


Glu Glu  Leu Ser Ser Glu Ser  Thr Pro Glu Asp Val  Leu Ser Gln 
    3440                 3445                 3450             


Gly Lys  Glu Ser Phe Glu His  Ile Ser Glu Asn Glu  Phe Ala Ser 
    3455                 3460                 3465             


Glu Ala  Glu Gln Ser Thr Pro  Ala Glu Gln Lys Glu  Leu Gly Ser 
    3470                 3475                 3480             


Glu Arg  Lys Glu Glu Asp Gln  Leu Ser Ser Glu Val  Val Thr Glu 
    3485                 3490                 3495             


Lys Ala  Gln Lys Glu Leu Lys  Lys Ser Gln Ile Asp  Thr Tyr Cys 
    3500                 3505                 3510             


Tyr Thr  Cys Lys Cys Pro Ile  Ser Ala Thr Asp Lys  Val Phe Gly 
    3515                 3520                 3525             


Thr His  Lys Asp His Glu Val  Ser Thr Leu Asp Thr  Ala Ile Ser 
    3530                 3535                 3540             


Ala Val  Lys Val Gln Leu Ala  Glu Phe Leu Glu Asn  Leu Gln Glu 
    3545                 3550                 3555             


Lys Ser  Leu Arg Ile Glu Ala  Phe Val Ser Glu Ile  Glu Ser Phe 
    3560                 3565                 3570             


Phe Asn  Thr Ile Glu Glu Asn  Cys Ser Lys Asn Glu  Lys Arg Leu 
    3575                 3580                 3585             


Glu Glu  Gln Asn Glu Glu Met  Met Lys Lys Val Leu  Ala Gln Tyr 
    3590                 3595                 3600             


Asp Glu  Lys Ala Gln Ser Phe  Glu Glu Val Lys Lys  Lys Lys Met 
    3605                 3610                 3615             


Glu Phe  Leu His Glu Gln Met  Val His Phe Leu Gln  Ser Met Asp 
    3620                 3625                 3630             


Thr Ala  Lys Asp Thr Leu Glu  Thr Ile Val Arg Glu  Ala Glu Glu 
    3635                 3640                 3645             


Leu Asp  Glu Ala Val Phe Leu  Thr Ser Phe Glu Glu  Ile Asn Glu 
    3650                 3655                 3660             


Arg Leu  Leu Ser Ala Met Glu  Ser Thr Ala Ser Leu  Glu Lys Met 
    3665                 3670                 3675             


Pro Ala  Ala Phe Ser Leu Phe  Glu His Tyr Asp Asp  Ser Ser Ala 
    3680                 3685                 3690             


Arg Ser  Asp Gln Met Leu Lys  Gln Val Ala Val Pro  Gln Pro Pro 
    3695                 3700                 3705             


Arg Leu  Glu Pro Gln Glu Pro  Asn Ser Ala Thr Ser  Thr Thr Ile 
    3710                 3715                 3720             


Ala Val  Tyr Trp Ser Met Asn  Lys Glu Asp Val Ile  Asp Ser Phe 
    3725                 3730                 3735             


Gln Val  Tyr Cys Met Glu Glu  Pro Gln Asp Asp Gln  Glu Val Asn 
    3740                 3745                 3750             


Glu Leu  Val Glu Glu Tyr Arg  Leu Thr Val Lys Glu  Ser Tyr Cys 
    3755                 3760                 3765             


Ile Phe  Glu Asp Leu Glu Pro  Asp Arg Cys Tyr Gln  Val Trp Val 
    3770                 3775                 3780             


Met Ala  Val Asn Phe Thr Gly  Cys Ser Leu Pro Ser  Glu Arg Ala 
    3785                 3790                 3795             


Ile Phe  Arg Thr Ala Pro Ser  Thr Pro Val Ile Arg  Ala Glu Asp 
    3800                 3805                 3810             


Cys Thr  Val Cys Trp Asn Thr  Ala Thr Ile Arg Trp  Arg Pro Thr 
    3815                 3820                 3825             


Thr Pro  Glu Ala Thr Glu Thr  Tyr Thr Leu Glu Tyr  Cys Arg Gln 
    3830                 3835                 3840             


His Ser  Pro Glu Gly Glu Gly  Leu Arg Ser Phe Ser  Gly Ile Lys 
    3845                 3850                 3855             


Gly Leu  Gln Leu Lys Val Asn  Leu Gln Pro Asn Asp  Asn Tyr Phe 
    3860                 3865                 3870             


Phe Tyr  Val Arg Ala Ile Asn  Ala Phe Gly Thr Ser  Glu Gln Ser 
    3875                 3880                 3885             


Glu Ala  Ala Leu Ile Ser Thr  Arg Gly Thr Arg Phe  Leu Leu Leu 
    3890                 3895                 3900             


Arg Glu  Thr Ala His Pro Ala  Leu His Ile Ser Ser  Ser Gly Thr 
    3905                 3910                 3915             


Val Ile  Ser Phe Gly Glu Arg  Arg Arg Leu Thr Glu  Ile Pro Ser 
    3920                 3925                 3930             


Val Leu  Gly Glu Glu Leu Pro  Ser Cys Gly Gln His  Tyr Trp Glu 
    3935                 3940                 3945             


Thr Thr  Val Thr Asp Cys Pro  Ala Tyr Arg Leu Gly  Ile Cys Ser 
    3950                 3955                 3960             


Ser Ser  Ala Val Gln Ala Gly  Ala Leu Gly Gln Gly  Glu Thr Ser 
    3965                 3970                 3975             


Trp Tyr  Met His Cys Ser Glu  Pro Gln Arg Tyr Thr  Phe Phe Tyr 
    3980                 3985                 3990             


Ser Gly  Ile Val Ser Asp Val  His Val Thr Glu Arg  Pro Ala Arg 
    3995                 4000                 4005             


Val Gly  Ile Leu Leu Asp Tyr  Asn Asn Gln Arg Leu  Ile Phe Ile 
    4010                 4015                 4020             


Asn Ala  Glu Ser Glu Gln Leu  Leu Phe Ile Ile Arg  His Arg Phe 
    4025                 4030                 4035             


Asn Glu  Gly Val His Pro Ala  Phe Ala Leu Glu Lys  Pro Gly Lys 
    4040                 4045                 4050             


Cys Thr  Leu His Leu Gly Ile  Glu Pro Pro Asp Ser  Val Arg His 
    4055                 4060                 4065             


Lys 
    


<210>  17
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Thr Ala Val His Ala Gly Asn Ile Asn Phe Lys Trp Asp Pro Lys 
1               5                   10                  15      


Ser Leu Glu Ile Arg Thr Leu Ala Val Glu Arg Leu Leu Glu Pro Leu 
            20                  25                  30          


Val Thr Gln Val Thr Thr Leu Val Asn Thr Asn Ser Lys Gly Pro Ser 
        35                  40                  45              


Asn Lys Lys Arg Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser 
    50                  55                  60                  


Val Glu Gln Ala Thr Glu Asn Phe Leu Glu Lys Gly Asp Lys Ile Ala 
65                  70                  75                  80  


Lys Glu Ser Gln Phe Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp 
                85                  90                  95      


Val Arg Lys Gln Gly Asp Leu Met Lys Ala Ala Ala Gly Glu Phe Ala 
            100                 105                 110         


Asp Asp Pro Cys Ser Ser Val Lys Arg Gly Asn Met Val Arg Ala Ala 
        115                 120                 125             


Arg Ala Leu Leu Ser Ala Val Thr Arg Leu Leu Ile Leu Ala Asp Met 
    130                 135                 140                 


Ala Asp Val Tyr Lys Leu Leu Val Gln Leu Lys Val Val Glu Asp Gly 
145                 150                 155                 160 


Ile Leu Lys Leu Arg Asn Ala Gly Asn Glu Gln Asp Leu Gly Ile Gln 
                165                 170                 175     


Tyr Lys Ala Leu Lys Pro Glu Val Asp Lys Leu Asn Ile Met Ala Ala 
            180                 185                 190         


Lys Arg Gln Gln Glu Leu Lys Asp Val Gly His Arg Asp Gln Met Ala 
        195                 200                 205             


Ala Ala Arg Gly Ile Leu Gln Lys Asn Val Pro Ile Leu Tyr Thr Ala 
    210                 215                 220                 


Ser Gln Ala Cys Leu Gln His Pro Asp Val Ala Ala Tyr Lys Ala Asn 
225                 230                 235                 240 


Arg Asp Leu Ile Tyr Lys Gln Leu Gln Gln Ala Val Thr Gly Ile Ser 
                245                 250                 255     


Asn Ala Ala Gln Ala Thr Ala Ser Asp Asp Ala Ser Gln His Gln Gly 
            260                 265                 270         


Gly Gly Gly Gly Glu Leu Ala Tyr Ala Leu Asn Asn Phe Asp Lys Gln 
        275                 280                 285             


Ile Ile Val Asp Pro Leu Ser Phe Ser Glu Glu Arg Phe Arg Pro Ser 
    290                 295                 300                 


Leu Glu Glu Arg Leu Glu Ser Ile Ile Ser Gly Ala Ala Leu Met Ala 
305                 310                 315                 320 


Asp Ser Ser Cys Thr Arg Asp Asp Arg Arg Glu Arg Ile Val Ala Glu 
                325                 330                 335     


Cys Asn Ala Val Arg Gln Ala Leu Gln Asp Leu Leu Ser Glu Tyr Met 
            340                 345                 350         


Gly Asn Ala Gly Arg Lys Glu Arg Ser Asp Ala Leu Asn Ser Ala Ile 
        355                 360                 365             


Asp Lys Met Thr Lys Lys Thr Arg Asp Leu Arg Arg Gln Leu Arg Lys 
    370                 375                 380                 


Ala Val Met Asp His Val Ser Asp Ser Phe Leu Glu Thr Asn Val Pro 
385                 390                 395                 400 


Leu Leu Val Leu Ile Glu Ala Ala Lys Asn Gly Asn Glu Lys Glu Val 
                405                 410                 415     


Lys Glu Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Ile Glu 
            420                 425                 430         


Val Ala Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys 
        435                 440                 445             


Leu Val Arg Met Ser Ala Ser Gln Leu Glu Ala Leu Cys Pro Gln Val 
    450                 455                 460                 


Ile Asn Ala Ala Leu Ala Leu Ala Ala Lys Pro Gln Ser Lys Leu Ala 
465                 470                 475                 480 


Gln Glu Asn Met Asp Leu Phe Lys Glu Gln Trp Glu Lys Gln Val Arg 
                485                 490                 495     


Val Leu Thr Asp Ala Val Asp Asp Ile Thr Ser Ile Asp Asp Phe Leu 
            500                 505                 510         


Ala Val Ser Glu Asn His Ile Leu Glu Asp Val Asn Lys Cys Val Ile 
        515                 520                 525             


Ala Leu Gln Glu Lys Asp Val Asp Gly Leu Asp Arg Thr Ala Gly Ala 
    530                 535                 540                 


Ile Arg Gly Arg Ala Ala Arg Val Ile His Val Val Thr Ser Glu Met 
545                 550                 555                 560 


Asp Asn Tyr Glu Pro Gly Val Tyr Thr Glu Lys Val Leu Glu Ala Thr 
                565                 570                 575     


Lys Leu Leu Ser Asn Thr Val Met Pro Arg Phe Thr Glu Gln Val Glu 
            580                 585                 590         


Ala Ala Val Glu Ala Leu Ser Ser Asp Pro Ala Gln Pro Met Asp Glu 
        595                 600                 605             


Asn Glu Phe Ile Asp Ala Ser Arg Leu Val Tyr Asp Gly Ile Arg Asp 
    610                 615                 620                 


Ile Arg Lys Ala Val Leu Met Ile Arg Thr Pro Glu Glu Leu Asp Asp 
625                 630                 635                 640 


Ser Asp Phe Glu Thr Glu Asp Phe Asp Val Arg Ser Arg Thr Ser Val 
                645                 650                 655     


Gln Thr Glu Asp Asp Gln Leu Ile Ala Gly Gln Ser Ala Arg Ala Ile 
            660                 665                 670         


Met Ala Gln Leu Pro Gln Glu Gln Lys Ala Lys Ile Ala Glu Gln Val 
        675                 680                 685             


Ala Ser Phe Gln Glu Glu Lys Ser Lys Leu Asp Ala Glu Val Ser Lys 
    690                 695                 700                 


Trp Asp Asp Ser Gly Asn Asp Ile Ile Val Leu Ala Lys Gln Met Cys 
705                 710                 715                 720 


Met Ile Met Met Glu Met Thr Asp Phe Thr Arg Gly Lys Gly Pro Leu 
                725                 730                 735     


Lys Asn Thr Ser Asp Val Ile Ser Ala Ala Lys Lys Ile Ala Glu Ala 
            740                 745                 750         


Gly Ser Arg Met Asp Lys Leu Gly Arg Thr Ile Ala Asp His Cys Pro 
        755                 760                 765             


Asp Ser Ala Cys Lys Gln Asp Leu Leu Ala Tyr Leu Gln Arg Ile Ala 
    770                 775                 780                 


Leu Tyr Cys His Gln Leu Asn Ile Cys Ser Lys Val Lys Ala Glu Val 
785                 790                 795                 800 


Gln Asn Leu Gly Gly Glu Leu Val Val Ser Gly Val Asp Ser Ala Met 
                805                 810                 815     


Ser Leu Ile Gln Ala Ala Lys Asn Leu Met Asn Ala Val Val Gln Thr 
            820                 825                 830         


Val Lys Ala Ser Tyr Val Ala Ser Thr Lys Tyr Gln Lys Ser Gln Gly 
        835                 840                 845             


Met Ala Ser Leu Asn Leu Pro Ala Val Ser Trp Lys Met Lys Ala Pro 
    850                 855                 860                 


Glu Lys Lys Pro Leu Val Lys Arg Glu Lys Gln Asp Glu Thr Gln Thr 
865                 870                 875                 880 


Lys Ile Lys Arg Ala Ser Gln Lys Lys His Val Asn Pro Val Gln Ala 
                885                 890                 895     


Leu Ser Glu Phe Lys Ala Met Asp Ser Ile 
            900                 905     


<210>  18
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 
1               5                   10                  15      


Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 
            20                  25                  30          


Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr 
    50                  55                  60                  


Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala 
65                  70                  75                  80  


Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala 
                85                  90                  95      


Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr 
            100                 105                 110         


Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro 
        115                 120                 125             


Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 
    130                 135                 140                 


Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu 
145                 150                 155                 160 


Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His 
                165                 170                 175     


Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro 
            180                 185                 190         


Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val 
        195                 200                 205             


Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His 
    210                 215                 220                 


Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu 
225                 230                 235                 240 


Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile 
                245                 250                 255     


Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala 
            260                 265                 270         


Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys 
        275                 280                 285             


Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu 
    290                 295                 300                 


Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly 
305                 310                 315                 320 


Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu 
                325                 330                 335     


Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser 
            340                 345                 350         


Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu 
        355                 360                 365             


His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr 
    370                 375                 380                 


Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly 
385                 390                 395                 400 


Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val 
                405                 410                 415     


Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr 
            420                 425                 430         


Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val 
        435                 440                 445             


Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala 
    450                 455                 460                 


Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met 
465                 470                 475                 480 


Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys 
                485                 490                 495     


Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly 
            500                 505                 510         


Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg 
        515                 520                 525             


Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His 
    530                 535                 540                 


Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe 
545                 550                 555                 560 


Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala 
                565                 570                 575     


Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly 
            580                 585                 590         


Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu 
        595                 600                 605             


Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp 
    610                 615                 620                 


Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu 
625                 630                 635                 640 


Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala 
                645                 650                 655     


Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys 
            660                 665                 670         


Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
        675                 680                 685             


Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly 
    690                 695                 700                 


Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His 
705                 710                 715                 720 


Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu 
                725                 730                 735     


His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly 
            740                 745                 750         


Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro 
        755                 760                 765             


Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu 
    770                 775                 780     


<210>  19
<211>  2701
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Glu Glu Gly Ala Val Ala Val Cys Val Arg Val Arg Pro Leu 
1               5                   10                  15      


Asn Ser Arg Glu Glu Ser Leu Gly Glu Thr Ala Gln Val Tyr Trp Lys 
            20                  25                  30          


Thr Asp Asn Asn Val Ile Tyr Gln Val Asp Gly Ser Lys Ser Phe Asn 
        35                  40                  45              


Phe Asp Arg Val Phe His Gly Asn Glu Thr Thr Lys Asn Val Tyr Glu 
    50                  55                  60                  


Glu Ile Ala Ala Pro Ile Ile Asp Ser Ala Ile Gln Gly Tyr Asn Gly 
65                  70                  75                  80  


Thr Ile Phe Ala Tyr Gly Gln Thr Ala Ser Gly Lys Thr Tyr Thr Met 
                85                  90                  95      


Met Gly Ser Glu Asp His Leu Gly Val Ile Pro Arg Ala Ile His Asp 
            100                 105                 110         


Ile Phe Gln Lys Ile Lys Lys Phe Pro Asp Arg Glu Phe Leu Leu Arg 
        115                 120                 125             


Val Ser Tyr Met Glu Ile Tyr Asn Glu Thr Ile Thr Asp Leu Leu Cys 
    130                 135                 140                 


Gly Thr Gln Lys Met Lys Pro Leu Ile Ile Arg Glu Asp Val Asn Arg 
145                 150                 155                 160 


Asn Val Tyr Val Ala Asp Leu Thr Glu Glu Val Val Tyr Thr Ser Glu 
                165                 170                 175     


Met Ala Leu Lys Trp Ile Thr Lys Gly Glu Lys Ser Arg His Tyr Gly 
            180                 185                 190         


Glu Thr Lys Met Asn Gln Arg Ser Ser Arg Ser His Thr Ile Phe Arg 
        195                 200                 205             


Met Ile Leu Glu Ser Arg Glu Lys Gly Glu Pro Ser Asn Cys Glu Gly 
    210                 215                 220                 


Ser Val Lys Val Ser His Leu Asn Leu Val Asp Leu Ala Gly Ser Glu 
225                 230                 235                 240 


Arg Ala Ala Gln Thr Gly Ala Ala Gly Val Arg Leu Lys Glu Gly Cys 
                245                 250                 255     


Asn Ile Asn Arg Ser Leu Phe Ile Leu Gly Gln Val Ile Lys Lys Leu 
            260                 265                 270         


Ser Asp Gly Gln Val Gly Gly Phe Ile Asn Tyr Arg Asp Ser Lys Leu 
        275                 280                 285             


Thr Arg Ile Leu Gln Asn Ser Leu Gly Gly Asn Ala Lys Thr Arg Ile 
    290                 295                 300                 


Ile Cys Thr Ile Thr Pro Val Ser Phe Asp Glu Thr Leu Thr Ala Leu 
305                 310                 315                 320 


Gln Phe Ala Ser Thr Ala Lys Tyr Met Lys Asn Thr Pro Tyr Val Asn 
                325                 330                 335     


Glu Val Ser Thr Asp Glu Ala Leu Leu Lys Arg Tyr Arg Lys Glu Ile 
            340                 345                 350         


Met Asp Leu Lys Lys Gln Leu Glu Glu Val Ser Leu Glu Thr Arg Ala 
        355                 360                 365             


Gln Ala Met Glu Lys Asp Gln Leu Ala Gln Leu Leu Glu Glu Lys Asp 
    370                 375                 380                 


Leu Leu Gln Lys Val Gln Asn Glu Lys Ile Glu Asn Leu Thr Arg Met 
385                 390                 395                 400 


Leu Val Thr Ser Ser Ser Leu Thr Leu Gln Gln Glu Leu Lys Ala Lys 
                405                 410                 415     


Arg Lys Arg Arg Val Thr Trp Cys Leu Gly Lys Ile Asn Lys Met Lys 
            420                 425                 430         


Asn Ser Asn Tyr Ala Asp Gln Phe Asn Ile Pro Thr Asn Ile Thr Thr 
        435                 440                 445             


Lys Thr His Lys Leu Ser Ile Asn Leu Leu Arg Glu Ile Asp Glu Ser 
    450                 455                 460                 


Val Cys Ser Glu Ser Asp Val Phe Ser Asn Thr Leu Asp Thr Leu Ser 
465                 470                 475                 480 


Glu Ile Glu Trp Asn Pro Ala Thr Lys Leu Leu Asn Gln Glu Asn Ile 
                485                 490                 495     


Glu Ser Glu Leu Asn Ser Leu Arg Ala Asp Tyr Asp Asn Leu Val Leu 
            500                 505                 510         


Asp Tyr Glu Gln Leu Arg Thr Glu Lys Glu Glu Met Glu Leu Lys Leu 
        515                 520                 525             


Lys Glu Lys Asn Asp Leu Asp Glu Phe Glu Ala Leu Glu Arg Lys Thr 
    530                 535                 540                 


Lys Lys Asp Gln Glu Met Gln Leu Ile His Glu Ile Ser Asn Leu Lys 
545                 550                 555                 560 


Asn Leu Val Lys His Ala Glu Val Tyr Asn Gln Asp Leu Glu Asn Glu 
                565                 570                 575     


Leu Ser Ser Lys Val Glu Leu Leu Arg Glu Lys Glu Asp Gln Ile Lys 
            580                 585                 590         


Lys Leu Gln Glu Tyr Ile Asp Ser Gln Lys Leu Glu Asn Ile Lys Met 
        595                 600                 605             


Asp Leu Ser Tyr Ser Leu Glu Ser Ile Glu Asp Pro Lys Gln Met Lys 
    610                 615                 620                 


Gln Thr Leu Phe Asp Ala Glu Thr Val Ala Leu Asp Ala Lys Arg Glu 
625                 630                 635                 640 


Ser Ala Phe Leu Arg Ser Glu Asn Leu Glu Leu Lys Glu Lys Met Lys 
                645                 650                 655     


Glu Leu Ala Thr Thr Tyr Lys Gln Met Glu Asn Asp Ile Gln Leu Tyr 
            660                 665                 670         


Gln Ser Gln Leu Glu Ala Lys Lys Lys Met Gln Val Asp Leu Glu Lys 
        675                 680                 685             


Glu Leu Gln Ser Ala Phe Asn Glu Ile Thr Lys Leu Thr Ser Leu Ile 
    690                 695                 700                 


Asp Gly Lys Val Pro Lys Asp Leu Leu Cys Asn Leu Glu Leu Glu Gly 
705                 710                 715                 720 


Lys Ile Thr Asp Leu Gln Lys Glu Leu Asn Lys Glu Val Glu Glu Asn 
                725                 730                 735     


Glu Ala Leu Arg Glu Glu Val Ile Leu Leu Ser Glu Leu Lys Ser Leu 
            740                 745                 750         


Pro Ser Glu Val Glu Arg Leu Arg Lys Glu Ile Gln Asp Lys Ser Glu 
        755                 760                 765             


Glu Leu His Ile Ile Thr Ser Glu Lys Asp Lys Leu Phe Ser Glu Val 
    770                 775                 780                 


Val His Lys Glu Ser Arg Val Gln Gly Leu Leu Glu Glu Ile Gly Lys 
785                 790                 795                 800 


Thr Lys Asp Asp Leu Ala Thr Thr Gln Ser Asn Tyr Lys Ser Thr Asp 
                805                 810                 815     


Gln Glu Phe Gln Asn Phe Lys Thr Leu His Met Asp Phe Glu Gln Lys 
            820                 825                 830         


Tyr Lys Met Val Leu Glu Glu Asn Glu Arg Met Asn Gln Glu Ile Val 
        835                 840                 845             


Asn Leu Ser Lys Glu Ala Gln Lys Phe Asp Ser Ser Leu Gly Ala Leu 
    850                 855                 860                 


Lys Thr Glu Leu Ser Tyr Lys Thr Gln Glu Leu Gln Glu Lys Thr Arg 
865                 870                 875                 880 


Glu Val Gln Glu Arg Leu Asn Glu Met Glu Gln Leu Lys Glu Gln Leu 
                885                 890                 895     


Glu Asn Arg Asp Ser Thr Leu Gln Thr Val Glu Arg Glu Lys Thr Leu 
            900                 905                 910         


Ile Thr Glu Lys Leu Gln Gln Thr Leu Glu Glu Val Lys Thr Leu Thr 
        915                 920                 925             


Gln Glu Lys Asp Asp Leu Lys Gln Leu Gln Glu Ser Leu Gln Ile Glu 
    930                 935                 940                 


Arg Asp Gln Leu Lys Ser Asp Ile His Asp Thr Val Asn Met Asn Ile 
945                 950                 955                 960 


Asp Thr Gln Glu Gln Leu Arg Asn Ala Leu Glu Ser Leu Lys Gln His 
                965                 970                 975     


Gln Glu Thr Ile Asn Thr Leu Lys Ser Lys Ile Ser Glu Glu Val Ser 
            980                 985                 990         


Arg Asn Leu His Met Glu Glu Asn  Thr Gly Glu Thr Lys  Asp Glu Phe 
        995                 1000                 1005             


Gln Gln  Lys Met Val Gly Ile  Asp Lys Lys Gln Asp  Leu Glu Ala 
    1010                 1015                 1020             


Lys Asn  Thr Gln Thr Leu Thr  Ala Asp Val Lys Asp  Asn Glu Ile 
    1025                 1030                 1035             


Ile Glu  Gln Gln Arg Lys Ile  Phe Ser Leu Ile Gln  Glu Lys Asn 
    1040                 1045                 1050             


Glu Leu  Gln Gln Met Leu Glu  Ser Val Ile Ala Glu  Lys Glu Gln 
    1055                 1060                 1065             


Leu Lys  Thr Asp Leu Lys Glu  Asn Ile Glu Met Thr  Ile Glu Asn 
    1070                 1075                 1080             


Gln Glu  Glu Leu Arg Leu Leu  Gly Asp Glu Leu Lys  Lys Gln Gln 
    1085                 1090                 1095             


Glu Ile  Val Ala Gln Glu Lys  Asn His Ala Ile Lys  Lys Glu Gly 
    1100                 1105                 1110             


Glu Leu  Ser Arg Thr Cys Asp  Arg Leu Ala Glu Val  Glu Glu Lys 
    1115                 1120                 1125             


Leu Lys  Glu Lys Ser Gln Gln  Leu Gln Glu Lys Gln  Gln Gln Leu 
    1130                 1135                 1140             


Leu Asn  Val Gln Glu Glu Met  Ser Glu Met Gln Lys  Lys Ile Asn 
    1145                 1150                 1155             


Glu Ile  Glu Asn Leu Lys Asn  Glu Leu Lys Asn Lys  Glu Leu Thr 
    1160                 1165                 1170             


Leu Glu  His Met Glu Thr Glu  Arg Leu Glu Leu Ala  Gln Lys Leu 
    1175                 1180                 1185             


Asn Glu  Asn Tyr Glu Glu Val  Lys Ser Ile Thr Lys  Glu Arg Lys 
    1190                 1195                 1200             


Val Leu  Lys Glu Leu Gln Lys  Ser Phe Glu Thr Glu  Arg Asp His 
    1205                 1210                 1215             


Leu Arg  Gly Tyr Ile Arg Glu  Ile Glu Ala Thr Gly  Leu Gln Thr 
    1220                 1225                 1230             


Lys Glu  Glu Leu Lys Ile Ala  His Ile His Leu Lys  Glu His Gln 
    1235                 1240                 1245             


Glu Thr  Ile Asp Glu Leu Arg  Arg Ser Val Ser Glu  Lys Thr Ala 
    1250                 1255                 1260             


Gln Ile  Ile Asn Thr Gln Asp  Leu Glu Lys Ser His  Thr Lys Leu 
    1265                 1270                 1275             


Gln Glu  Glu Ile Pro Val Leu  His Glu Glu Gln Glu  Leu Leu Pro 
    1280                 1285                 1290             


Asn Val  Lys Glu Val Ser Glu  Thr Gln Glu Thr Met  Asn Glu Leu 
    1295                 1300                 1305             


Glu Leu  Leu Thr Glu Gln Ser  Thr Thr Lys Asp Ser  Thr Thr Leu 
    1310                 1315                 1320             


Ala Arg  Ile Glu Met Glu Arg  Leu Arg Leu Asn Glu  Lys Phe Gln 
    1325                 1330                 1335             


Glu Ser  Gln Glu Glu Ile Lys  Ser Leu Thr Lys Glu  Arg Asp Asn 
    1340                 1345                 1350             


Leu Lys  Thr Ile Lys Glu Ala  Leu Glu Val Lys His  Asp Gln Leu 
    1355                 1360                 1365             


Lys Glu  His Ile Arg Glu Thr  Leu Ala Lys Ile Gln  Glu Ser Gln 
    1370                 1375                 1380             


Ser Lys  Gln Glu Gln Ser Leu  Asn Met Lys Glu Lys  Asp Asn Glu 
    1385                 1390                 1395             


Thr Thr  Lys Ile Val Ser Glu  Met Glu Gln Phe Lys  Pro Lys Asp 
    1400                 1405                 1410             


Ser Ala  Leu Leu Arg Ile Glu  Ile Glu Met Leu Gly  Leu Ser Lys 
    1415                 1420                 1425             


Arg Leu  Gln Glu Ser His Asp  Glu Met Lys Ser Val  Ala Lys Glu 
    1430                 1435                 1440             


Lys Asp  Asp Leu Gln Arg Leu  Gln Glu Val Leu Gln  Ser Glu Ser 
    1445                 1450                 1455             


Asp Gln  Leu Lys Glu Asn Ile  Lys Glu Ile Val Ala  Lys His Leu 
    1460                 1465                 1470             


Glu Thr  Glu Glu Glu Leu Lys  Val Ala His Cys Cys  Leu Lys Glu 
    1475                 1480                 1485             


Gln Glu  Glu Thr Ile Asn Glu  Leu Arg Val Asn Leu  Ser Glu Lys 
    1490                 1495                 1500             


Glu Thr  Glu Ile Ser Thr Ile  Gln Lys Gln Leu Glu  Ala Ile Asn 
    1505                 1510                 1515             


Asp Lys  Leu Gln Asn Lys Ile  Gln Glu Ile Tyr Glu  Lys Glu Glu 
    1520                 1525                 1530             


Gln Phe  Asn Ile Lys Gln Ile  Ser Glu Val Gln Glu  Lys Val Asn 
    1535                 1540                 1545             


Glu Leu  Lys Gln Phe Lys Glu  His Arg Lys Ala Lys  Asp Ser Ala 
    1550                 1555                 1560             


Leu Gln  Ser Ile Glu Ser Lys  Met Leu Glu Leu Thr  Asn Arg Leu 
    1565                 1570                 1575             


Gln Glu  Ser Gln Glu Glu Ile  Gln Ile Met Ile Lys  Glu Lys Glu 
    1580                 1585                 1590             


Glu Met  Lys Arg Val Gln Glu  Ala Leu Gln Ile Glu  Arg Asp Gln 
    1595                 1600                 1605             


Leu Lys  Glu Asn Thr Lys Glu  Ile Val Ala Lys Met  Lys Glu Ser 
    1610                 1615                 1620             


Gln Glu  Lys Glu Tyr Gln Phe  Leu Lys Met Thr Ala  Val Asn Glu 
    1625                 1630                 1635             


Thr Gln  Glu Lys Met Cys Glu  Ile Glu His Leu Lys  Glu Gln Phe 
    1640                 1645                 1650             


Glu Thr  Gln Lys Leu Asn Leu  Glu Asn Ile Glu Thr  Glu Asn Ile 
    1655                 1660                 1665             


Arg Leu  Thr Gln Ile Leu His  Glu Asn Leu Glu Glu  Met Arg Ser 
    1670                 1675                 1680             


Val Thr  Lys Glu Arg Asp Asp  Leu Arg Ser Val Glu  Glu Thr Leu 
    1685                 1690                 1695             


Lys Val  Glu Arg Asp Gln Leu  Lys Glu Asn Leu Arg  Glu Thr Ile 
    1700                 1705                 1710             


Thr Arg  Asp Leu Glu Lys Gln  Glu Glu Leu Lys Ile  Val His Met 
    1715                 1720                 1725             


His Leu  Lys Glu His Gln Glu  Thr Ile Asp Lys Leu  Arg Gly Ile 
    1730                 1735                 1740             


Val Ser  Glu Lys Thr Asn Glu  Ile Ser Asn Met Gln  Lys Asp Leu 
    1745                 1750                 1755             


Glu His  Ser Asn Asp Ala Leu  Lys Ala Gln Asp Leu  Lys Ile Gln 
    1760                 1765                 1770             


Glu Glu  Leu Arg Ile Ala His  Met His Leu Lys Glu  Gln Gln Glu 
    1775                 1780                 1785             


Thr Ile  Asp Lys Leu Arg Gly  Ile Val Ser Glu Lys  Thr Asp Lys 
    1790                 1795                 1800             


Leu Ser  Asn Met Gln Lys Asp  Leu Glu Asn Ser Asn  Ala Lys Leu 
    1805                 1810                 1815             


Gln Glu  Lys Ile Gln Glu Leu  Lys Ala Asn Glu His  Gln Leu Ile 
    1820                 1825                 1830             


Thr Leu  Lys Lys Asp Val Asn  Glu Thr Gln Lys Lys  Val Ser Glu 
    1835                 1840                 1845             


Met Glu  Gln Leu Lys Lys Gln  Ile Lys Asp Gln Ser  Leu Thr Leu 
    1850                 1855                 1860             


Ser Lys  Leu Glu Ile Glu Asn  Leu Asn Leu Ala Gln  Lys Leu His 
    1865                 1870                 1875             


Glu Asn  Leu Glu Glu Met Lys  Ser Val Met Lys Glu  Arg Asp Asn 
    1880                 1885                 1890             


Leu Arg  Arg Val Glu Glu Thr  Leu Lys Leu Glu Arg  Asp Gln Leu 
    1895                 1900                 1905             


Lys Glu  Ser Leu Gln Glu Thr  Lys Ala Arg Asp Leu  Glu Ile Gln 
    1910                 1915                 1920             


Gln Glu  Leu Lys Thr Ala Arg  Met Leu Ser Lys Glu  His Lys Glu 
    1925                 1930                 1935             


Thr Val  Asp Lys Leu Arg Glu  Lys Ile Ser Glu Lys  Thr Ile Gln 
    1940                 1945                 1950             


Ile Ser  Asp Ile Gln Lys Asp  Leu Asp Lys Ser Lys  Asp Glu Leu 
    1955                 1960                 1965             


Gln Lys  Lys Ile Gln Glu Leu  Gln Lys Lys Glu Leu  Gln Leu Leu 
    1970                 1975                 1980             


Arg Val  Lys Glu Asp Val Asn  Met Ser His Lys Lys  Ile Asn Glu 
    1985                 1990                 1995             


Met Glu  Gln Leu Lys Lys Gln  Phe Glu Ala Gln Asn  Leu Ser Met 
    2000                 2005                 2010             


Gln Ser  Val Arg Met Asp Asn  Phe Gln Leu Thr Lys  Lys Leu His 
    2015                 2020                 2025             


Glu Ser  Leu Glu Glu Ile Arg  Ile Val Ala Lys Glu  Arg Asp Glu 
    2030                 2035                 2040             


Leu Arg  Arg Ile Lys Glu Ser  Leu Lys Met Glu Arg  Asp Gln Phe 
    2045                 2050                 2055             


Ile Ala  Thr Leu Arg Glu Met  Ile Ala Arg Asp Arg  Gln Asn His 
    2060                 2065                 2070             


Gln Val  Lys Pro Glu Lys Arg  Leu Leu Ser Asp Gly  Gln Gln His 
    2075                 2080                 2085             


Leu Thr  Glu Ser Leu Arg Glu  Lys Cys Ser Arg Ile  Lys Glu Leu 
    2090                 2095                 2100             


Leu Lys  Arg Tyr Ser Glu Met  Asp Asp His Tyr Glu  Cys Leu Asn 
    2105                 2110                 2115             


Arg Leu  Ser Leu Asp Leu Glu  Lys Glu Ile Glu Phe  Gln Lys Glu 
    2120                 2125                 2130             


Leu Ser  Met Arg Val Lys Ala  Asn Leu Ser Leu Pro  Tyr Leu Gln 
    2135                 2140                 2145             


Thr Lys  His Ile Glu Lys Leu  Phe Thr Ala Asn Gln  Arg Cys Ser 
    2150                 2155                 2160             


Met Glu  Phe His Arg Ile Met  Lys Lys Leu Lys Tyr  Val Leu Ser 
    2165                 2170                 2175             


Tyr Val  Thr Lys Ile Lys Glu  Glu Gln His Glu Ser  Ile Asn Lys 
    2180                 2185                 2190             


Phe Glu  Met Asp Phe Ile Asp  Glu Val Glu Lys Gln  Lys Glu Leu 
    2195                 2200                 2205             


Leu Ile  Lys Ile Gln His Leu  Gln Gln Asp Cys Asp  Val Pro Ser 
    2210                 2215                 2220             


Arg Glu  Leu Arg Asp Leu Lys  Leu Asn Gln Asn Met  Asp Leu His 
    2225                 2230                 2235             


Ile Glu  Glu Ile Leu Lys Asp  Phe Ser Glu Ser Glu  Phe Pro Ser 
    2240                 2245                 2250             


Ile Lys  Thr Glu Phe Gln Gln  Val Leu Ser Asn Arg  Lys Glu Met 
    2255                 2260                 2265             


Thr Gln  Phe Leu Glu Glu Trp  Leu Asn Thr Arg Phe  Asp Ile Glu 
    2270                 2275                 2280             


Lys Leu  Lys Asn Gly Ile Gln  Lys Glu Asn Asp Arg  Ile Cys Gln 
    2285                 2290                 2295             


Val Asn  Asn Phe Phe Asn Asn  Arg Ile Ile Ala Ile  Met Asn Glu 
    2300                 2305                 2310             


Ser Thr  Glu Phe Glu Glu Arg  Ser Ala Thr Ile Ser  Lys Glu Trp 
    2315                 2320                 2325             


Glu Gln  Asp Leu Lys Ser Leu  Lys Glu Lys Asn Glu  Lys Leu Phe 
    2330                 2335                 2340             


Lys Asn  Tyr Gln Thr Leu Lys  Thr Ser Leu Ala Ser  Gly Ala Gln 
    2345                 2350                 2355             


Val Asn  Pro Thr Thr Gln Asp  Asn Lys Asn Pro His  Val Thr Ser 
    2360                 2365                 2370             


Arg Ala  Thr Gln Leu Thr Thr  Glu Lys Ile Arg Glu  Leu Glu Asn 
    2375                 2380                 2385             


Ser Leu  His Glu Ala Lys Glu  Ser Ala Met His Lys  Glu Ser Lys 
    2390                 2395                 2400             


Ile Ile  Lys Met Gln Lys Glu  Leu Glu Val Thr Asn  Asp Ile Ile 
    2405                 2410                 2415             


Ala Lys  Leu Gln Ala Lys Val  His Glu Ser Asn Lys  Cys Leu Glu 
    2420                 2425                 2430             


Lys Thr  Lys Glu Thr Ile Gln  Val Leu Gln Asp Lys  Val Ala Leu 
    2435                 2440                 2445             


Gly Ala  Lys Pro Tyr Lys Glu  Glu Ile Glu Asp Leu  Lys Met Lys 
    2450                 2455                 2460             


Leu Val  Lys Ile Asp Leu Glu  Lys Met Lys Asn Ala  Lys Glu Phe 
    2465                 2470                 2475             


Glu Lys  Glu Ile Ser Ala Thr  Lys Ala Thr Val Glu  Tyr Gln Lys 
    2480                 2485                 2490             


Glu Val  Ile Arg Leu Leu Arg  Glu Asn Leu Arg Arg  Ser Gln Gln 
    2495                 2500                 2505             


Ala Gln  Asp Thr Ser Val Ile  Ser Glu His Thr Asp  Pro Gln Pro 
    2510                 2515                 2520             


Ser Asn  Lys Pro Leu Thr Cys  Gly Gly Gly Ser Gly  Ile Val Gln 
    2525                 2530                 2535             


Asn Thr  Lys Ala Leu Ile Leu  Lys Ser Glu His Ile  Arg Leu Glu 
    2540                 2545                 2550             


Lys Glu  Ile Ser Lys Leu Lys  Gln Gln Asn Glu Gln  Leu Ile Lys 
    2555                 2560                 2565             


Gln Lys  Asn Glu Leu Leu Ser  Asn Asn Gln His Leu  Ser Asn Glu 
    2570                 2575                 2580             


Val Lys  Thr Trp Lys Glu Arg  Thr Leu Lys Arg Glu  Ala His Lys 
    2585                 2590                 2595             


Gln Val  Thr Cys Glu Asn Ser  Pro Lys Ser Pro Lys  Val Thr Gly 
    2600                 2605                 2610             


Thr Ala  Ser Lys Lys Lys Gln  Ile Thr Pro Ser Gln  Cys Lys Glu 
    2615                 2620                 2625             


Arg Asn  Leu Gln Asp Pro Val  Pro Lys Glu Ser Pro  Lys Ser Cys 
    2630                 2635                 2640             


Phe Phe  Asp Ser Arg Ser Lys  Ser Leu Pro Ser Pro  His Pro Val 
    2645                 2650                 2655             


Arg Tyr  Phe Asp Asn Ser Ser  Leu Gly Leu Cys Pro  Glu Val Gln 
    2660                 2665                 2670             


Asn Ala  Gly Ala Glu Ser Val  Asp Ser Gln Pro Gly  Pro Trp His 
    2675                 2680                 2685             


Ala Ser  Ser Gly Lys Asp Val  Pro Glu Cys Lys Thr  Gln 
    2690                 2695                 2700     


<210>  20
<211>  951
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ser Ala Arg Glu Val Ala Val Leu Leu Leu Trp Leu Ser Cys Tyr 
1               5                   10                  15      


Gly Ser Ala Leu Trp Arg Tyr Ser Thr Asn Ser Pro Asn Tyr Arg Ile 
            20                  25                  30          


Phe Ser Thr Arg Ser Thr Ile Lys Leu Glu Tyr Glu Gly Thr Leu Phe 
        35                  40                  45              


Thr Glu Trp Ser Val Pro Glu Thr Cys Phe Val Leu Asn Lys Ser Ser 
    50                  55                  60                  


Pro Thr Thr Glu Leu Arg Cys Ser Ser Pro Gly Val His Ala Ile Lys 
65                  70                  75                  80  


Pro Ile Val Thr Gly Pro Asp Glu Glu Glu Arg Tyr Leu Phe Val Glu 
                85                  90                  95      


Ser Ser His Thr Cys Phe Leu Trp Tyr Tyr Arg Val Arg His Phe Phe 
            100                 105                 110         


Asn Asn Phe Thr Gln Leu Ile Thr Val Trp Ala Tyr Asp Pro Glu Ser 
        115                 120                 125             


Ala Asp Pro Asp Glu Leu Leu Gly Asn Ala Glu Glu Pro Ser Ile Asn 
    130                 135                 140                 


Ser Ile Val Leu Ser Thr Gln Met Ala Thr Leu Gly Gln Lys Pro Val 
145                 150                 155                 160 


Ile His Thr Val Leu Lys Arg Lys Val Tyr Ser Ser Asn Glu Lys Met 
                165                 170                 175     


Arg Arg Gly Thr Trp Arg Ile Val Val Pro Met Thr Lys Asp Asp Ala 
            180                 185                 190         


Leu Lys Glu Ile Arg Gly Asn Gln Val Thr Phe Gln Asp Cys Phe Ile 
        195                 200                 205             


Ala Asp Phe Leu Ile Leu Leu Thr Phe Pro Leu Leu Thr Ile Pro Glu 
    210                 215                 220                 


Ile Pro Gly Tyr Leu Pro Ile Ser Ser Pro Arg Gly Ser Gln Leu Met 
225                 230                 235                 240 


Ala Ser Trp Asp Ala Cys Val Val Ala Ser Ala Val Leu Val Thr Asp 
                245                 250                 255     


Met Glu Thr Phe His Thr Thr Asp Ser Phe Lys Ser Trp Thr Arg Ile 
            260                 265                 270         


Arg Val Pro Pro Asp Ile Leu Ser Asp Asp Glu Arg Arg Ser Val Ala 
        275                 280                 285             


His Val Ile Leu Ser Arg Asp Gly Ile Val Phe Leu Ile Asn Gly Val 
    290                 295                 300                 


Leu Tyr Ile Lys Ser Phe Arg Gly Phe Ile Arg Leu Gly Gly Ile Val 
305                 310                 315                 320 


Asn Leu Pro Asp Gly Gly Ile Thr Gly Ile Ser Ser Arg Lys Trp Cys 
                325                 330                 335     


Trp Val Asn Tyr Leu Leu Lys Ala Lys Gly Arg Arg Ser Thr Phe Ala 
            340                 345                 350         


Val Trp Thr Glu Asn Glu Ile Tyr Leu Gly Ser Ile Leu Leu Lys Phe 
        355                 360                 365             


Ala Arg Leu Val Thr Thr Thr Glu Leu Lys Asn Ile Leu Ser Leu Ser 
    370                 375                 380                 


Val Thr Ala Thr Leu Thr Ile Asp Arg Val Glu Tyr Thr Gly His Pro 
385                 390                 395                 400 


Leu Glu Ile Ala Val Phe Leu Asn Tyr Cys Thr Val Cys Asn Val Thr 
                405                 410                 415     


Lys Lys Ile Phe Leu Val Ile Tyr Asn Glu Asp Thr Lys Gln Trp Val 
            420                 425                 430         


Ser Gln Asp Phe Thr Leu Asp Ala Pro Ile Asp Ser Val Thr Met Pro 
        435                 440                 445             


His Phe Thr Phe Ser Ala Leu Pro Gly Leu Leu Leu Trp Asn Lys His 
    450                 455                 460                 


Ser Ile Tyr Tyr Cys Tyr His Asn Phe Thr Phe Thr Gly Ile Leu Gln 
465                 470                 475                 480 


Thr Pro Ala Gly His Gly Asn Leu Ser Met Leu Ser Asn Asp Ser Ile 
                485                 490                 495     


Ile His Glu Val Phe Ile Asp Tyr Tyr Gly Asp Ile Leu Val Lys Met 
            500                 505                 510         


Glu Asn Asn Val Ile Phe Tyr Ser Lys Ile Asn Thr Arg Asp Ala Val 
        515                 520                 525             


Lys Leu His Leu Trp Thr Asn Tyr Thr Thr Arg Ala Phe Ile Phe Leu 
    530                 535                 540                 


Ser Thr Ser Gly Gln Thr Tyr Phe Leu Tyr Ala Leu Asp Asp Gly Thr 
545                 550                 555                 560 


Ile Gln Ile Gln Asp Tyr Pro Leu His Leu Glu Ala Gln Ser Ile Ala 
                565                 570                 575     


Phe Thr Thr Lys Asp Lys Cys Pro Tyr Met Ala Phe His Asn Asn Val 
            580                 585                 590         


Ala His Val Phe Tyr Phe Leu Asp Lys Gly Glu Ala Leu Thr Val Trp 
        595                 600                 605             


Thr Gln Ile Val Tyr Pro Glu Asn Thr Gly Leu Tyr Val Ile Val Glu 
    610                 615                 620                 


Ser Tyr Gly Pro Lys Ile Leu Gln Glu Ser His Glu Ile Ser Phe Glu 
625                 630                 635                 640 


Ala Ala Phe Gly Tyr Cys Thr Lys Thr Leu Thr Leu Thr Phe Tyr Gln 
                645                 650                 655     


Asn Val Asp Tyr Glu Arg Ile Ser Asp Tyr Phe Glu Thr Gln Asp Lys 
            660                 665                 670         


His Thr Gly Leu Val Leu Val Gln Phe Arg Pro Ser Glu Tyr Ser Lys 
        675                 680                 685             


Ala Cys Pro Ile Ala Gln Lys Val Phe Gln Ile Ala Val Gly Cys Asp 
    690                 695                 700                 


Asp Lys Lys Phe Ile Ala Ile Lys Gly Phe Ser Lys Lys Gly Cys His 
705                 710                 715                 720 


His His Asp Phe Ser Tyr Val Ile Glu Lys Ser Tyr Leu Arg His Gln 
                725                 730                 735     


Pro Ser Lys Asn Leu Arg Val Arg Tyr Ile Trp Gly Glu Tyr Gly Cys 
            740                 745                 750         


Pro Leu Arg Leu Asp Phe Thr Glu Lys Phe Gln Pro Val Val Gln Leu 
        755                 760                 765             


Phe Asp Asp Asn Gly Tyr Val Lys Asp Val Glu Ala Asn Phe Ile Val 
    770                 775                 780                 


Trp Glu Ile His Gly Arg Asp Asp Tyr Ser Phe Asn Asn Thr Met Ala 
785                 790                 795                 800 


Gln Ser Gly Cys Leu His Glu Ala Gln Thr Trp Lys Ser Met Ile Glu 
                805                 810                 815     


Leu Asn Lys His Leu Pro Leu Glu Glu Val Trp Gly Pro Glu Asn Tyr 
            820                 825                 830         


Lys His Cys Phe Ser Tyr Ala Ile Gly Lys Pro Gly Asp Leu Asn Gln 
        835                 840                 845             


Pro Tyr Glu Ile Ile Asn Ser Ser Asn Gly Asn His Ile Phe Trp Pro 
    850                 855                 860                 


Met Gly His Ser Gly Met Tyr Val Phe Arg Val Lys Ile Leu Asp Pro 
865                 870                 875                 880 


Asn Tyr Ser Phe Cys Asn Leu Thr Ala Met Phe Ala Ile Glu Thr Phe 
                885                 890                 895     


Gly Leu Ile Pro Ser Pro Ser Val Tyr Leu Val Ala Ser Phe Leu Phe 
            900                 905                 910         


Val Leu Met Leu Leu Phe Phe Thr Ile Leu Val Leu Ser Tyr Phe Arg 
        915                 920                 925             


Tyr Met Arg Ile Tyr Arg Arg Tyr Ile Tyr Glu Pro Leu His Lys Pro 
    930                 935                 940                 


Gln Arg Lys Arg Lys Lys Asn 
945                 950     


<210>  21
<211>  1224
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Leu Thr Lys Phe Glu Thr Lys Ser Ala Arg Val Lys Gly Leu Ser 
1               5                   10                  15      


Phe His Pro Lys Arg Pro Trp Ile Leu Thr Ser Leu His Asn Gly Val 
            20                  25                  30          


Ile Gln Leu Trp Asp Tyr Arg Met Cys Thr Leu Ile Asp Lys Phe Asp 
        35                  40                  45              


Glu His Asp Gly Pro Val Arg Gly Ile Asp Phe His Lys Gln Gln Pro 
    50                  55                  60                  


Leu Phe Val Ser Gly Gly Asp Asp Tyr Lys Ile Lys Val Trp Asn Tyr 
65                  70                  75                  80  


Lys Leu Arg Arg Cys Leu Phe Thr Leu Leu Gly His Leu Asp Tyr Ile 
                85                  90                  95      


Arg Thr Thr Phe Phe His His Glu Tyr Pro Trp Ile Leu Ser Ala Ser 
            100                 105                 110         


Asp Asp Gln Thr Ile Arg Val Trp Asn Trp Gln Ser Arg Thr Cys Val 
        115                 120                 125             


Cys Val Leu Thr Gly His Asn His Tyr Val Met Cys Ala Gln Phe His 
    130                 135                 140                 


Pro Thr Glu Asp Leu Val Val Ser Ala Ser Leu Asp Gln Thr Val Arg 
145                 150                 155                 160 


Val Trp Asp Ile Ser Gly Leu Arg Lys Lys Asn Leu Ser Pro Gly Ala 
                165                 170                 175     


Val Glu Ser Asp Val Arg Gly Ile Thr Gly Val Asp Leu Phe Gly Thr 
            180                 185                 190         


Thr Asp Ala Val Val Lys His Val Leu Glu Gly His Asp Arg Gly Val 
        195                 200                 205             


Asn Trp Ala Ala Phe His Pro Thr Met Pro Leu Ile Val Ser Gly Ala 
    210                 215                 220                 


Asp Asp Arg Gln Val Lys Ile Trp Arg Met Asn Glu Ser Lys Ala Trp 
225                 230                 235                 240 


Glu Val Asp Thr Cys Arg Gly His Tyr Asn Asn Val Ser Cys Ala Val 
                245                 250                 255     


Phe His Pro Arg Gln Glu Leu Ile Leu Ser Asn Ser Glu Asp Lys Ser 
            260                 265                 270         


Ile Arg Val Trp Asp Met Ser Lys Arg Thr Gly Val Gln Thr Phe Arg 
        275                 280                 285             


Arg Asp His Asp Arg Phe Trp Val Leu Ala Ala His Pro Asn Leu Asn 
    290                 295                 300                 


Leu Phe Ala Ala Gly His Asp Gly Gly Met Ile Val Phe Lys Leu Glu 
305                 310                 315                 320 


Arg Glu Arg Pro Ala Tyr Ala Val His Gly Asn Met Leu His Tyr Val 
                325                 330                 335     


Lys Asp Arg Phe Leu Arg Gln Leu Asp Phe Asn Ser Ser Lys Asp Val 
            340                 345                 350         


Ala Val Met Gln Leu Arg Ser Gly Ser Lys Phe Pro Val Phe Asn Met 
        355                 360                 365             


Ser Tyr Asn Pro Ala Glu Asn Ala Val Leu Leu Cys Thr Arg Ala Ser 
    370                 375                 380                 


Asn Leu Glu Asn Ser Thr Tyr Asp Leu Tyr Thr Ile Pro Lys Asp Ala 
385                 390                 395                 400 


Asp Ser Gln Asn Pro Asp Ala Pro Glu Gly Lys Arg Ser Ser Gly Leu 
                405                 410                 415     


Thr Ala Val Trp Val Ala Arg Asn Arg Phe Ala Val Leu Asp Arg Met 
            420                 425                 430         


His Ser Leu Leu Ile Lys Asn Leu Lys Asn Glu Ile Thr Lys Lys Val 
        435                 440                 445             


Gln Val Pro Asn Cys Asp Glu Ile Phe Tyr Ala Gly Thr Gly Asn Leu 
    450                 455                 460                 


Leu Leu Arg Asp Ala Asp Ser Ile Thr Leu Phe Asp Val Gln Gln Lys 
465                 470                 475                 480 


Arg Thr Leu Ala Ser Val Lys Ile Ser Lys Val Lys Tyr Val Ile Trp 
                485                 490                 495     


Ser Ala Asp Met Ser His Val Ala Leu Leu Ala Lys His Ala Ile Val 
            500                 505                 510         


Ile Cys Asn Arg Lys Leu Asp Ala Leu Cys Asn Ile His Glu Asn Ile 
        515                 520                 525             


Arg Val Lys Ser Gly Ala Trp Asp Glu Ser Gly Val Phe Ile Tyr Thr 
    530                 535                 540                 


Thr Ser Asn His Ile Lys Tyr Ala Val Thr Thr Gly Asp His Gly Ile 
545                 550                 555                 560 


Ile Arg Thr Leu Asp Leu Pro Ile Tyr Val Thr Arg Val Lys Gly Asn 
                565                 570                 575     


Asn Val Tyr Cys Leu Asp Arg Glu Cys Arg Pro Arg Val Leu Thr Ile 
            580                 585                 590         


Asp Pro Thr Glu Phe Lys Phe Lys Leu Ala Leu Ile Asn Arg Lys Tyr 
        595                 600                 605             


Asp Glu Val Leu His Met Val Arg Asn Ala Lys Leu Val Gly Gln Ser 
    610                 615                 620                 


Ile Ile Ala Tyr Leu Gln Lys Lys Gly Tyr Pro Glu Val Ala Leu His 
625                 630                 635                 640 


Phe Val Lys Asp Glu Lys Thr Arg Phe Ser Leu Ala Leu Glu Cys Gly 
                645                 650                 655     


Asn Ile Glu Ile Ala Leu Glu Ala Ala Lys Ala Leu Asp Asp Lys Asn 
            660                 665                 670         


Cys Trp Glu Lys Leu Gly Glu Val Ala Leu Leu Gln Gly Asn His Gln 
        675                 680                 685             


Ile Val Glu Met Cys Tyr Gln Arg Thr Lys Asn Phe Asp Lys Leu Ser 
    690                 695                 700                 


Phe Leu Tyr Leu Ile Thr Gly Asn Leu Glu Lys Leu Arg Lys Met Met 
705                 710                 715                 720 


Lys Ile Ala Glu Ile Arg Lys Asp Met Ser Gly His Tyr Gln Asn Ala 
                725                 730                 735     


Leu Tyr Leu Gly Asp Val Ser Glu Arg Val Arg Ile Leu Lys Asn Cys 
            740                 745                 750         


Gly Gln Lys Ser Leu Ala Tyr Leu Thr Ala Ala Thr His Gly Leu Asp 
        755                 760                 765             


Glu Glu Ala Glu Ser Leu Lys Glu Thr Phe Asp Pro Glu Lys Glu Thr 
    770                 775                 780                 


Ile Pro Asp Ile Asp Pro Asn Ala Lys Leu Leu Gln Pro Pro Ala Pro 
785                 790                 795                 800 


Ile Met Pro Leu Asp Thr Asn Trp Pro Leu Leu Thr Val Ser Lys Gly 
                805                 810                 815     


Phe Phe Glu Gly Thr Ile Ala Ser Lys Gly Lys Gly Gly Ala Leu Ala 
            820                 825                 830         


Ala Asp Ile Asp Ile Asp Thr Val Gly Thr Glu Gly Trp Gly Glu Asp 
        835                 840                 845             


Ala Glu Leu Gln Leu Asp Glu Asp Gly Phe Val Glu Ala Thr Glu Gly 
    850                 855                 860                 


Leu Gly Asp Asp Ala Leu Gly Lys Gly Gln Glu Glu Gly Gly Gly Trp 
865                 870                 875                 880 


Asp Val Glu Glu Asp Leu Glu Leu Pro Pro Glu Leu Asp Ile Ser Pro 
                885                 890                 895     


Gly Ala Ala Gly Gly Ala Glu Asp Gly Phe Phe Val Pro Pro Thr Lys 
            900                 905                 910         


Gly Thr Ser Pro Thr Gln Ile Trp Cys Asn Asn Ser Gln Leu Pro Val 
        915                 920                 925             


Asp His Ile Leu Ala Gly Ser Phe Glu Thr Ala Met Arg Leu Leu His 
    930                 935                 940                 


Asp Gln Val Gly Val Ile Gln Phe Gly Pro Tyr Lys Gln Leu Phe Leu 
945                 950                 955                 960 


Gln Thr Tyr Ala Arg Gly Arg Thr Thr Tyr Gln Ala Leu Pro Cys Leu 
                965                 970                 975     


Pro Ser Met Tyr Gly Tyr Pro Asn Arg Asn Trp Lys Asp Ala Gly Leu 
            980                 985                 990         


Lys Asn Gly Val Pro Ala Val Gly  Leu Lys Leu Asn Asp  Leu Ile Gln 
        995                 1000                 1005             


Arg Leu  Gln Leu Cys Tyr Gln  Leu Thr Thr Val Gly  Lys Phe Glu 
    1010                 1015                 1020             


Glu Ala  Val Glu Lys Phe Arg  Ser Ile Leu Leu Ser  Val Pro Leu 
    1025                 1030                 1035             


Leu Val  Val Asp Asn Lys Gln  Glu Ile Ala Glu Ala  Gln Gln Leu 
    1040                 1045                 1050             


Ile Thr  Ile Cys Arg Glu Tyr  Ile Val Gly Leu Ser  Val Glu Thr 
    1055                 1060                 1065             


Glu Arg  Lys Lys Leu Pro Lys  Glu Thr Leu Glu Gln  Gln Lys Arg 
    1070                 1075                 1080             


Ile Cys  Glu Met Ala Ala Tyr  Phe Thr His Ser Asn  Leu Gln Pro 
    1085                 1090                 1095             


Val His  Met Ile Leu Val Leu  Arg Thr Ala Leu Asn  Leu Phe Phe 
    1100                 1105                 1110             


Lys Leu  Lys Asn Phe Lys Thr  Ala Ala Thr Phe Ala  Arg Arg Leu 
    1115                 1120                 1125             


Leu Glu  Leu Gly Pro Lys Pro  Glu Val Ala Gln Gln  Thr Arg Lys 
    1130                 1135                 1140             


Ile Leu  Ser Ala Cys Glu Lys  Asn Pro Thr Asp Ala  Tyr Gln Leu 
    1145                 1150                 1155             


Asn Tyr  Asp Met His Asn Pro  Phe Asp Ile Cys Ala  Ala Ser Tyr 
    1160                 1165                 1170             


Arg Pro  Ile Tyr Arg Gly Lys  Pro Val Glu Lys Cys  Pro Leu Ser 
    1175                 1180                 1185             


Gly Ala  Cys Tyr Ser Pro Glu  Phe Lys Gly Gln Ile  Cys Arg Val 
    1190                 1195                 1200             


Thr Thr  Val Thr Glu Ile Gly  Lys Asp Val Ile Gly  Leu Arg Ile 
    1205                 1210                 1215             


Ser Pro  Leu Gln Phe Arg 
    1220                 


<210>  22
<211>  1464
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      


Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Val Glu Gly Gln Asp 
            20                  25                  30          


Glu Asp Ile Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg Tyr His 
        35                  40                  45              


Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val Cys Asp 
    50                  55                  60                  


Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr Lys Asn 
65                  70                  75                  80  


Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val Cys Pro 
                85                  90                  95      


Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val Glu Gly 
            100                 105                 110         


Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro 
        115                 120                 125             


Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala 
145                 150                 155                 160 


Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly Ile Ser 
                165                 170                 175     


Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro 
            180                 185                 190         


Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro 
        195                 200                 205             


Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly 
    210                 215                 220                 


Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg 
225                 230                 235                 240 


Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro 
                245                 250                 255     


Gly Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly 
            260                 265                 270         


Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu 
        275                 280                 285             


Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg 
    290                 295                 300                 


Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly 
305                 310                 315                 320 


Ala Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro 
                325                 330                 335     


Thr Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys 
            340                 345                 350         


Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly 
        355                 360                 365             


Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro 
    370                 375                 380                 


Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn 
385                 390                 395                 400 


Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly 
                405                 410                 415     


Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn 
            420                 425                 430         


Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys 
        435                 440                 445             


Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 
    450                 455                 460                 


Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr Gly Leu 
465                 470                 475                 480 


Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro 
                485                 490                 495     


Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly 
            500                 505                 510         


Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg 
        515                 520                 525             


Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro 
    530                 535                 540                 


Gly Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly 
545                 550                 555                 560 


Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln 
                565                 570                 575     


Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro 
            580                 585                 590         


Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly 
        595                 600                 605             


Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro 
    610                 615                 620                 


Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro 
625                 630                 635                 640 


Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly 
                645                 650                 655     


Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro 
            660                 665                 670         


Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln 
        675                 680                 685             


Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly 
    690                 695                 700                 


Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser 
705                 710                 715                 720 


Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala 
                725                 730                 735     


Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly 
            740                 745                 750         


Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro 
        755                 760                 765             


Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser 
    770                 775                 780                 


Gly Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro 
                805                 810                 815     


Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala 
            820                 825                 830         


Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly 
        835                 840                 845             


Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala 
    850                 855                 860                 


Arg Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala 
865                 870                 875                 880 


Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly 
                885                 890                 895     


Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu 
            900                 905                 910         


Thr Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro 
        915                 920                 925             


Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly 
    930                 935                 940                 


Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val 
945                 950                 955                 960 


Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro 
                965                 970                 975     


Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly 
            980                 985                 990         


Glu Arg Gly Pro Pro Gly Pro Met  Gly Pro Pro Gly Leu  Ala Gly Pro 
        995                 1000                 1005             


Pro Gly  Glu Ser Gly Arg Glu  Gly Ala Pro Gly Ala  Glu Gly Ser 
    1010                 1015                 1020             


Pro Gly  Arg Asp Gly Ser Pro  Gly Ala Lys Gly Asp  Arg Gly Glu 
    1025                 1030                 1035             


Thr Gly  Pro Ala Gly Pro Pro  Gly Ala Pro Gly Ala  Pro Gly Ala 
    1040                 1045                 1050             


Pro Gly  Pro Val Gly Pro Ala  Gly Lys Ser Gly Asp  Arg Gly Glu 
    1055                 1060                 1065             


Thr Gly  Pro Ala Gly Pro Thr  Gly Pro Val Gly Pro  Val Gly Ala 
    1070                 1075                 1080             


Arg Gly  Pro Ala Gly Pro Gln  Gly Pro Arg Gly Asp  Lys Gly Glu 
    1085                 1090                 1095             


Thr Gly  Glu Gln Gly Asp Arg  Gly Ile Lys Gly His  Arg Gly Phe 
    1100                 1105                 1110             


Ser Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Ser  Pro Gly Glu 
    1115                 1120                 1125             


Gln Gly  Pro Ser Gly Ala Ser  Gly Pro Ala Gly Pro  Arg Gly Pro 
    1130                 1135                 1140             


Pro Gly  Ser Ala Gly Ala Pro  Gly Lys Asp Gly Leu  Asn Gly Leu 
    1145                 1150                 1155             


Pro Gly  Pro Ile Gly Pro Pro  Gly Pro Arg Gly Arg  Thr Gly Asp 
    1160                 1165                 1170             


Ala Gly  Pro Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1175                 1180                 1185             


Pro Gly  Pro Pro Ser Ala Gly  Phe Asp Phe Ser Phe  Leu Pro Gln 
    1190                 1195                 1200             


Pro Pro  Gln Glu Lys Ala His  Asp Gly Gly Arg Tyr  Tyr Arg Ala 
    1205                 1210                 1215             


Asp Asp  Ala Asn Val Val Arg  Asp Arg Asp Leu Glu  Val Asp Thr 
    1220                 1225                 1230             


Thr Leu  Lys Ser Leu Ser Gln  Gln Ile Glu Asn Ile  Arg Ser Pro 
    1235                 1240                 1245             


Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Thr Cys Arg  Asp Leu Lys 
    1250                 1255                 1260             


Met Cys  His Ser Asp Trp Lys  Ser Gly Glu Tyr Trp  Ile Asp Pro 
    1265                 1270                 1275             


Asn Gln  Gly Cys Asn Leu Asp  Ala Ile Lys Val Phe  Cys Asn Met 
    1280                 1285                 1290             


Glu Thr  Gly Glu Thr Cys Val  Tyr Pro Thr Gln Pro  Ser Val Ala 
    1295                 1300                 1305             


Gln Lys  Asn Trp Tyr Ile Ser  Lys Asn Pro Lys Asp  Lys Arg His 
    1310                 1315                 1320             


Val Trp  Phe Gly Glu Ser Met  Thr Asp Gly Phe Gln  Phe Glu Tyr 
    1325                 1330                 1335             


Gly Gly  Gln Gly Ser Asp Pro  Ala Asp Val Ala Ile  Gln Leu Thr 
    1340                 1345                 1350             


Phe Leu  Arg Leu Met Ser Thr  Glu Ala Ser Gln Asn  Ile Thr Tyr 
    1355                 1360                 1365             


His Cys  Lys Asn Ser Val Ala  Tyr Met Asp Gln Gln  Thr Gly Asn 
    1370                 1375                 1380             


Leu Lys  Lys Ala Leu Leu Leu  Gln Gly Ser Asn Glu  Ile Glu Ile 
    1385                 1390                 1395             


Arg Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr Ser Val  Thr Val Asp 
    1400                 1405                 1410             


Gly Cys  Thr Ser His Thr Gly  Ala Trp Gly Lys Thr  Val Ile Glu 
    1415                 1420                 1425             


Tyr Lys  Thr Thr Lys Thr Ser  Arg Leu Pro Ile Ile  Asp Val Ala 
    1430                 1435                 1440             


Pro Leu  Asp Val Gly Ala Pro  Asp Gln Glu Phe Gly  Phe Asp Val 
    1445                 1450                 1455             


Gly Pro  Val Cys Phe Leu 
    1460                 


<210>  23
<211>  1366
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 
1               5                   10                  15      


Leu Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Glu Thr Val Arg Lys 
            20                  25                  30          


Gly Pro Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly 
        35                  40                  45              


Pro Pro Gly Arg Asp Gly Glu Asp Gly Pro Thr Gly Pro Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln 
65                  70                  75                  80  


Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met 
                85                  90                  95      


Gly Pro Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly 
            100                 105                 110         


Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro 
        115                 120                 125             


Ala Gly Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp 
    130                 135                 140                 


Gly His Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly 
145                 150                 155                 160 


Pro Gln Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe 
                165                 170                 175     


Lys Gly Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro 
            180                 185                 190         


Gly Ala Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly 
        195                 200                 205             


Thr Pro Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg 
    210                 215                 220                 


Val Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val 
225                 230                 235                 240 


Gly Pro Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly 
                245                 250                 255     


Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn 
            260                 265                 270         


Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro 
        275                 280                 285             


Gly Leu Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly 
    290                 295                 300                 


Leu Thr Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala 
                325                 330                 335     


Gly Ala Thr Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly 
            340                 345                 350         


Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro 
        355                 360                 365             


Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn 
    370                 375                 380                 


Gly Glu Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly 
385                 390                 395                 400 


Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val 
                405                 410                 415     


Met Gly Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg 
            420                 425                 430         


Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly 
        435                 440                 445             


Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys 
    450                 455                 460                 


Glu Gly Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile 
465                 470                 475                 480 


Gly Pro Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly 
                485                 490                 495     


Pro Lys Gly Pro Thr Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His 
            500                 505                 510         


Ala Gly Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn 
        515                 520                 525             


Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly 
    530                 535                 540                 


Glu Gln Gly Pro Pro Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro 
545                 550                 555                 560 


Ser Gly Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His 
                565                 570                 575     


Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly 
            580                 585                 590         


Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro Thr Gly Pro Ile Gly Ser 
        595                 600                 605             


Arg Gly Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro 
    610                 615                 620                 


Gly Val Val Gly Ala Val Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly 
625                 630                 635                 640 


Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu 
                645                 650                 655     


Lys Gly Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp 
            660                 665                 670         


Gly Ala Arg Gly Ala Pro Gly Ala Val Gly Ala Pro Gly Pro Ala Gly 
        675                 680                 685             


Ala Thr Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro 
    690                 695                 700                 


Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala 
705                 710                 715                 720 


Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly 
                725                 730                 735     


Ala Lys Gly Glu Arg Gly Ala Lys Gly Pro Lys Gly Glu Asn Gly Val 
            740                 745                 750         


Val Gly Pro Thr Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn 
        755                 760                 765             


Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly 
    770                 775                 780                 


Met Thr Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro 
785                 790                 795                 800 


Ser Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu 
                805                 810                 815     


Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr Gly 
            820                 825                 830         


Glu Val Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro 
        835                 840                 845             


Ser Gly Glu Ala Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln 
    850                 855                 860                 


Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly 
865                 870                 875                 880 


Glu Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro 
                885                 890                 895     


Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val 
            900                 905                 910         


Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly 
        915                 920                 925             


Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His 
    930                 935                 940                 


Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala 
945                 950                 955                 960 


Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly 
                965                 970                 975     


Asn Arg Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala 
            980                 985                 990         


Val Gly Pro Arg Gly Pro Ser Gly  Pro Gln Gly Ile Arg  Gly Asp Lys 
        995                 1000                 1005             


Gly Glu  Pro Gly Glu Lys Gly  Pro Arg Gly Leu Pro  Gly Leu Lys 
    1010                 1015                 1020             


Gly His  Asn Gly Leu Gln Gly  Leu Pro Gly Ile Ala  Gly His His 
    1025                 1030                 1035             


Gly Asp  Gln Gly Ala Pro Gly  Ser Val Gly Pro Ala  Gly Pro Arg 
    1040                 1045                 1050             


Gly Pro  Ala Gly Pro Ser Gly  Pro Ala Gly Lys Asp  Gly Arg Thr 
    1055                 1060                 1065             


Gly His  Pro Gly Thr Val Gly  Pro Ala Gly Ile Arg  Gly Pro Gln 
    1070                 1075                 1080             


Gly His  Gln Gly Pro Ala Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1085                 1090                 1095             


Gly Pro  Pro Gly Val Ser Gly  Gly Gly Tyr Asp Phe  Gly Tyr Asp 
    1100                 1105                 1110             


Gly Asp  Phe Tyr Arg Ala Asp  Gln Pro Arg Ser Ala  Pro Ser Leu 
    1115                 1120                 1125             


Arg Pro  Lys Asp Tyr Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1130                 1135                 1140             


Asn Gln  Ile Glu Thr Leu Leu  Thr Pro Glu Gly Ser  Arg Lys Asn 
    1145                 1150                 1155             


Pro Ala  Arg Thr Cys Arg Asp  Leu Arg Leu Ser His  Pro Glu Trp 
    1160                 1165                 1170             


Ser Ser  Gly Tyr Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Met 
    1175                 1180                 1185             


Asp Ala  Ile Lys Val Tyr Cys  Asp Phe Ser Thr Gly  Glu Thr Cys 
    1190                 1195                 1200             


Ile Arg  Ala Gln Pro Glu Asn  Ile Pro Ala Lys Asn  Trp Tyr Arg 
    1205                 1210                 1215             


Ser Ser  Lys Asp Lys Lys His  Val Trp Leu Gly Glu  Thr Ile Asn 
    1220                 1225                 1230             


Ala Gly  Ser Gln Phe Glu Tyr  Asn Val Glu Gly Val  Thr Ser Lys 
    1235                 1240                 1245             


Glu Met  Ala Thr Gln Leu Ala  Phe Met Arg Leu Leu  Ala Asn Tyr 
    1250                 1255                 1260             


Ala Ser  Gln Asn Ile Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr 
    1265                 1270                 1275             


Met Asp  Glu Glu Thr Gly Asn  Leu Lys Lys Ala Val  Ile Leu Gln 
    1280                 1285                 1290             


Gly Ser  Asn Asp Val Glu Leu  Val Ala Glu Gly Asn  Ser Arg Phe 
    1295                 1300                 1305             


Thr Tyr  Thr Val Leu Val Asp  Gly Cys Ser Lys Lys  Thr Asn Glu 
    1310                 1315                 1320             


Trp Gly  Lys Thr Ile Ile Glu  Tyr Lys Thr Asn Lys  Pro Ser Arg 
    1325                 1330                 1335             


Leu Pro  Phe Leu Asp Ile Ala  Pro Leu Asp Ile Gly  Gly Ala Asp 
    1340                 1345                 1350             


Gln Glu  Phe Phe Val Asp Ile  Gly Pro Val Cys Phe  Lys 
    1355                 1360                 1365     


<210>  24
<211>  1019
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Leu Gln Gly Thr Cys Ser Val Leu Leu Leu Trp Gly Ile Leu Gly 
1               5                   10                  15      


Ala Ile Gln Ala Gln Gln Gln Glu Val Ile Ser Pro Asp Thr Thr Glu 
            20                  25                  30          


Arg Asn Asn Asn Cys Pro Glu Lys Thr Asp Cys Pro Ile His Val Tyr 
        35                  40                  45              


Phe Val Leu Asp Thr Ser Glu Ser Val Thr Met Gln Ser Pro Thr Asp 
    50                  55                  60                  


Ile Leu Leu Phe His Met Lys Gln Phe Val Pro Gln Phe Ile Ser Gln 
65                  70                  75                  80  


Leu Gln Asn Glu Phe Tyr Leu Asp Gln Val Ala Leu Ser Trp Arg Tyr 
                85                  90                  95      


Gly Gly Leu His Phe Ser Asp Gln Val Glu Val Phe Ser Pro Pro Gly 
            100                 105                 110         


Ser Asp Arg Ala Ser Phe Ile Lys Asn Leu Gln Gly Ile Ser Ser Phe 
        115                 120                 125             


Arg Arg Gly Thr Phe Thr Asp Cys Ala Leu Ala Asn Met Thr Glu Gln 
    130                 135                 140                 


Ile Arg Gln Asp Arg Ser Lys Gly Thr Val His Phe Ala Val Val Ile 
145                 150                 155                 160 


Thr Asp Gly His Val Thr Gly Ser Pro Cys Gly Gly Ile Lys Leu Gln 
                165                 170                 175     


Ala Glu Arg Ala Arg Glu Glu Gly Ile Arg Leu Phe Ala Val Ala Pro 
            180                 185                 190         


Asn Gln Asn Leu Lys Glu Gln Gly Leu Arg Asp Ile Ala Ser Thr Pro 
        195                 200                 205             


His Glu Leu Tyr Arg Asn Asp Tyr Ala Thr Met Leu Pro Asp Ser Thr 
    210                 215                 220                 


Glu Ile Asp Gln Asp Thr Ile Asn Arg Ile Ile Lys Val Met Lys His 
225                 230                 235                 240 


Glu Ala Tyr Gly Glu Cys Tyr Lys Val Ser Cys Leu Glu Ile Pro Gly 
                245                 250                 255     


Pro Ser Gly Pro Lys Gly Tyr Arg Gly Gln Lys Gly Ala Lys Gly Asn 
            260                 265                 270         


Met Gly Glu Pro Gly Glu Pro Gly Gln Lys Gly Arg Gln Gly Asp Pro 
        275                 280                 285             


Gly Ile Glu Gly Pro Ile Gly Phe Pro Gly Pro Lys Gly Val Pro Gly 
    290                 295                 300                 


Phe Lys Gly Glu Lys Gly Glu Phe Gly Ala Asp Gly Arg Lys Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Ala Gly Lys Asn Gly Thr Asp Gly Gln Lys Gly Lys Leu 
                325                 330                 335     


Gly Arg Ile Gly Pro Pro Gly Cys Lys Gly Asp Pro Gly Asn Arg Gly 
            340                 345                 350         


Pro Asp Gly Tyr Pro Gly Glu Ala Gly Ser Pro Gly Glu Arg Gly Asp 
        355                 360                 365             


Gln Gly Gly Lys Gly Asp Pro Gly Arg Pro Gly Arg Arg Gly Pro Pro 
    370                 375                 380                 


Gly Glu Ile Gly Ala Lys Gly Ser Lys Gly Tyr Gln Gly Asn Ser Gly 
385                 390                 395                 400 


Ala Pro Gly Ser Pro Gly Val Lys Gly Ala Lys Gly Gly Pro Gly Pro 
                405                 410                 415     


Arg Gly Pro Lys Gly Glu Pro Gly Arg Arg Gly Asp Pro Gly Thr Lys 
            420                 425                 430         


Gly Ser Pro Gly Ser Asp Gly Pro Lys Gly Glu Lys Gly Asp Pro Gly 
        435                 440                 445             


Pro Glu Gly Pro Arg Gly Leu Ala Gly Glu Val Gly Asn Lys Gly Ala 
    450                 455                 460                 


Lys Gly Asp Arg Gly Leu Pro Gly Pro Arg Gly Pro Gln Gly Ala Leu 
465                 470                 475                 480 


Gly Glu Pro Gly Lys Gln Gly Ser Arg Gly Asp Pro Gly Asp Ala Gly 
                485                 490                 495     


Pro Arg Gly Asp Ser Gly Gln Pro Gly Pro Lys Gly Asp Pro Gly Arg 
            500                 505                 510         


Pro Gly Phe Ser Tyr Pro Gly Pro Arg Gly Ala Pro Gly Glu Lys Gly 
        515                 520                 525             


Glu Pro Gly Pro Arg Gly Pro Glu Gly Gly Arg Gly Asp Phe Gly Leu 
    530                 535                 540                 


Lys Gly Glu Pro Gly Arg Lys Gly Glu Lys Gly Glu Pro Ala Asp Pro 
545                 550                 555                 560 


Gly Pro Pro Gly Glu Pro Gly Pro Arg Gly Pro Arg Gly Val Pro Gly 
                565                 570                 575     


Pro Glu Gly Glu Pro Gly Pro Pro Gly Asp Pro Gly Leu Thr Glu Cys 
            580                 585                 590         


Asp Val Met Thr Tyr Val Arg Glu Thr Cys Gly Cys Cys Asp Cys Glu 
        595                 600                 605             


Lys Arg Cys Gly Ala Leu Asp Val Val Phe Val Ile Asp Ser Ser Glu 
    610                 615                 620                 


Ser Ile Gly Tyr Thr Asn Phe Thr Leu Glu Lys Asn Phe Val Ile Asn 
625                 630                 635                 640 


Val Val Asn Arg Leu Gly Ala Ile Ala Lys Asp Pro Lys Ser Glu Thr 
                645                 650                 655     


Gly Thr Arg Val Gly Val Val Gln Tyr Ser His Glu Gly Thr Phe Glu 
            660                 665                 670         


Ala Ile Gln Leu Asp Asp Glu Arg Ile Asp Ser Leu Ser Ser Phe Lys 
        675                 680                 685             


Glu Ala Val Lys Asn Leu Glu Trp Ile Ala Gly Gly Thr Trp Thr Pro 
    690                 695                 700                 


Ser Ala Leu Lys Phe Ala Tyr Asp Arg Leu Ile Lys Glu Ser Arg Arg 
705                 710                 715                 720 


Gln Lys Thr Arg Val Phe Ala Val Val Ile Thr Asp Gly Arg His Asp 
                725                 730                 735     


Pro Arg Asp Asp Asp Leu Asn Leu Arg Ala Leu Cys Asp Arg Asp Val 
            740                 745                 750         


Thr Val Thr Ala Ile Gly Ile Gly Asp Met Phe His Glu Lys His Glu 
        755                 760                 765             


Ser Glu Asn Leu Tyr Ser Ile Ala Cys Asp Lys Pro Gln Gln Val Arg 
    770                 775                 780                 


Asn Met Thr Leu Phe Ser Asp Leu Val Ala Glu Lys Phe Ile Asp Asp 
785                 790                 795                 800 


Met Glu Asp Val Leu Cys Pro Asp Pro Gln Ile Val Cys Pro Asp Leu 
                805                 810                 815     


Pro Cys Gln Thr Glu Leu Ser Val Ala Gln Cys Thr Gln Arg Pro Val 
            820                 825                 830         


Asp Ile Val Phe Leu Leu Asp Gly Ser Glu Arg Leu Gly Glu Gln Asn 
        835                 840                 845             


Phe His Lys Ala Arg Arg Phe Val Glu Gln Val Ala Arg Arg Leu Thr 
    850                 855                 860                 


Leu Ala Arg Arg Asp Asp Asp Pro Leu Asn Ala Arg Val Ala Leu Leu 
865                 870                 875                 880 


Gln Phe Gly Gly Pro Gly Glu Gln Gln Val Ala Phe Pro Leu Ser His 
                885                 890                 895     


Asn Leu Thr Ala Ile His Glu Ala Leu Glu Thr Thr Gln Tyr Leu Asn 
            900                 905                 910         


Ser Phe Ser His Val Gly Ala Gly Val Val His Ala Ile Asn Ala Ile 
        915                 920                 925             


Val Arg Ser Pro Arg Gly Gly Ala Arg Arg His Ala Glu Leu Ser Phe 
    930                 935                 940                 


Val Phe Leu Thr Asp Gly Val Thr Gly Asn Asp Ser Leu His Glu Ser 
945                 950                 955                 960 


Ala His Ser Met Arg Lys Gln Asn Val Val Pro Thr Val Leu Ala Leu 
                965                 970                 975     


Gly Ser Asp Val Asp Met Asp Val Leu Thr Thr Leu Ser Leu Gly Asp 
            980                 985                 990         


Arg Ala Ala Val Phe His Glu Lys  Asp Tyr Asp Ser Leu  Ala Gln Pro 
        995                 1000                 1005             


Gly Phe  Phe Asp Arg Phe Ile  Arg Trp Ile Cys 
    1010                 1015                 


<210>  25
<211>  2263
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Met Leu Leu Ile Leu Phe Leu Val Ile Ile Cys Ser His Ile Ser 
1               5                   10                  15      


Val Asn Gln Asp Ser Gly Pro Glu Tyr Ala Asp Val Val Phe Leu Val 
            20                  25                  30          


Asp Ser Ser Asp Arg Leu Gly Ser Lys Ser Phe Pro Phe Val Lys Met 
        35                  40                  45              


Phe Ile Thr Lys Met Ile Ser Ser Leu Pro Ile Glu Ala Asp Lys Tyr 
    50                  55                  60                  


Arg Val Ala Leu Ala Gln Tyr Ser Asp Lys Leu His Ser Glu Phe His 
65                  70                  75                  80  


Leu Ser Thr Phe Lys Gly Arg Ser Pro Met Leu Asn His Leu Arg Lys 
                85                  90                  95      


Asn Phe Gly Phe Ile Gly Gly Ser Leu Gln Ile Gly Lys Ala Leu Gln 
            100                 105                 110         


Glu Ala His Arg Thr Tyr Phe Ser Ala Pro Ala Asn Gly Arg Asp Lys 
        115                 120                 125             


Lys Gln Phe Pro Pro Ile Leu Val Val Leu Ala Ser Ser Glu Ser Glu 
    130                 135                 140                 


Asp Asn Val Glu Glu Ala Ser Lys Ala Leu Arg Lys Asp Gly Val Lys 
145                 150                 155                 160 


Ile Ile Ser Val Gly Val Gln Lys Ala Ser Glu Glu Asn Leu Lys Ala 
                165                 170                 175     


Met Ala Thr Ser Gln Phe His Phe Asn Leu Arg Thr Val Arg Asp Leu 
            180                 185                 190         


Ser Met Phe Ser Gln Asn Met Thr His Ile Ile Lys Asp Val Ile Lys 
        195                 200                 205             


Tyr Lys Glu Gly Ala Val Asp Asp Ile Phe Val Glu Ala Cys Gln Gly 
    210                 215                 220                 


Pro Ser Met Ala Asp Val Val Phe Leu Leu Asp Met Ser Ile Asn Gly 
225                 230                 235                 240 


Ser Glu Glu Asn Phe Asp Tyr Leu Lys Gly Phe Leu Glu Glu Ser Val 
                245                 250                 255     


Ser Ala Leu Asp Ile Lys Glu Asn Cys Met Arg Val Gly Leu Val Ala 
            260                 265                 270         


Tyr Ser Asn Glu Thr Lys Val Ile Asn Ser Leu Ser Met Gly Ile Asn 
        275                 280                 285             


Lys Ser Glu Val Leu Gln His Ile Gln Asn Leu Ser Pro Arg Thr Gly 
    290                 295                 300                 


Lys Ala Tyr Thr Gly Ala Ala Ile Lys Lys Leu Arg Lys Glu Val Phe 
305                 310                 315                 320 


Ser Ala Arg Asn Gly Ser Arg Lys Asn Gln Gly Val Pro Gln Ile Ala 
                325                 330                 335     


Val Leu Val Thr His Arg Asp Ser Glu Asp Asn Val Thr Lys Ala Ala 
            340                 345                 350         


Val Asn Leu Arg Arg Glu Gly Val Thr Ile Phe Thr Leu Gly Ile Glu 
        355                 360                 365             


Gly Ala Ser Asp Thr Gln Leu Glu Lys Ile Ala Ser His Pro Ala Glu 
    370                 375                 380                 


Gln Tyr Val Ser Lys Leu Lys Thr Phe Ala Asp Leu Ala Ala His Asn 
385                 390                 395                 400 


Gln Thr Phe Leu Lys Lys Leu Arg Asn Gln Ile Thr His Thr Val Ser 
                405                 410                 415     


Val Phe Ser Glu Arg Thr Glu Thr Leu Lys Ser Gly Cys Val Asp Thr 
            420                 425                 430         


Glu Glu Ala Asp Ile Tyr Leu Leu Ile Asp Gly Ser Gly Ser Thr Gln 
        435                 440                 445             


Ala Thr Asp Phe His Glu Met Lys Thr Phe Leu Ser Glu Val Val Gly 
    450                 455                 460                 


Met Phe Asn Ile Ala Pro His Lys Val Arg Val Gly Ala Val Gln Tyr 
465                 470                 475                 480 


Ala Asp Ser Trp Asp Leu Glu Phe Glu Ile Asn Lys Tyr Ser Asn Lys 
                485                 490                 495     


Gln Asp Leu Gly Lys Ala Ile Glu Asn Ile Arg Gln Met Gly Gly Asn 
            500                 505                 510         


Thr Asn Thr Gly Ala Ala Leu Asn Phe Thr Leu Ser Leu Leu Gln Lys 
        515                 520                 525             


Ala Lys Lys Gln Arg Gly Asn Lys Val Pro Cys His Leu Val Val Leu 
    530                 535                 540                 


Thr Asn Gly Met Ser Lys Asp Ser Ile Leu Glu Pro Ala Asn Arg Leu 
545                 550                 555                 560 


Arg Glu Glu His Ile Arg Val Tyr Ala Ile Gly Ile Lys Glu Ala Asn 
                565                 570                 575     


Gln Thr Gln Leu Arg Glu Ile Ala Gly Glu Glu Lys Arg Val Tyr Tyr 
            580                 585                 590         


Val His Asp Phe Asp Ala Leu Lys Asp Ile Arg Asn Gln Val Val Gln 
        595                 600                 605             


Glu Ile Cys Thr Glu Glu Ala Cys Lys Glu Met Lys Ala Asp Ile Met 
    610                 615                 620                 


Phe Leu Val Asp Ser Ser Gly Ser Ile Gly Pro Glu Asn Phe Ser Lys 
625                 630                 635                 640 


Met Lys Thr Phe Met Lys Asn Leu Val Ser Lys Ser Gln Ile Gly Pro 
                645                 650                 655     


Asp Arg Val Gln Ile Gly Val Val Gln Phe Ser Asp Ile Asn Lys Glu 
            660                 665                 670         


Glu Phe Gln Leu Asn Arg Phe Met Ser Gln Ser Asp Ile Ser Asn Ala 
        675                 680                 685             


Ile Asp Gln Met Ala His Ile Gly Gln Thr Thr Leu Thr Gly Ser Ala 
    690                 695                 700                 


Leu Ser Phe Val Ser Gln Tyr Phe Ser Pro Thr Lys Gly Ala Arg Pro 
705                 710                 715                 720 


Asn Ile Arg Lys Phe Leu Ile Leu Ile Thr Asp Gly Glu Ala Gln Asp 
                725                 730                 735     


Ile Val Lys Glu Pro Ala Val Val Leu Arg Gln Glu Gly Val Ile Ile 
            740                 745                 750         


Tyr Ser Val Gly Val Phe Gly Ser Asn Val Thr Gln Leu Glu Glu Ile 
        755                 760                 765             


Ser Gly Arg Pro Glu Met Val Phe Tyr Val Glu Asn Phe Asp Ile Leu 
    770                 775                 780                 


Gln Arg Ile Glu Asp Asp Leu Val Phe Gly Ile Cys Ser Pro Arg Glu 
785                 790                 795                 800 


Glu Cys Lys Arg Ile Glu Val Leu Asp Val Val Phe Val Ile Asp Ser 
                805                 810                 815     


Ser Gly Ser Ile Asp Tyr Asp Glu Tyr Asn Ile Met Lys Asp Phe Met 
            820                 825                 830         


Ile Gly Leu Val Lys Lys Ala Asp Val Gly Lys Asn Gln Val Arg Phe 
        835                 840                 845             


Gly Ala Leu Lys Tyr Ala Asp Asp Pro Glu Val Leu Phe Tyr Leu Asp 
    850                 855                 860                 


Asp Phe Gly Thr Lys Leu Glu Val Ile Ser Val Leu Gln Asn Asp Gln 
865                 870                 875                 880 


Ala Met Gly Gly Ser Thr Tyr Thr Ala Glu Ala Leu Gly Phe Ser Asp 
                885                 890                 895     


His Met Phe Thr Glu Ala Arg Gly Ser Arg Leu Asn Lys Gly Val Pro 
            900                 905                 910         


Gln Val Leu Ile Val Ile Thr Asp Gly Glu Ser His Asp Ala Asp Lys 
        915                 920                 925             


Leu Asn Ala Thr Ala Lys Ala Leu Arg Asp Lys Gly Ile Leu Val Leu 
    930                 935                 940                 


Ala Val Gly Ile Asp Gly Ala Asn Pro Val Glu Leu Leu Ala Met Ala 
945                 950                 955                 960 


Gly Ser Ser Asp Lys Tyr Phe Phe Val Glu Thr Phe Gly Gly Leu Lys 
                965                 970                 975     


Gly Ile Phe Ser Asp Val Thr Ala Ser Val Cys Asn Ser Ser Lys Val 
            980                 985                 990         


Asp Cys Glu Ile Asp Lys Val Asp  Leu Val Phe Leu Met  Asp Gly Ser 
        995                 1000                 1005             


Thr Ser  Ile Gln Pro Asn Asp  Phe Lys Lys Met Lys  Glu Phe Leu 
    1010                 1015                 1020             


Ala Ser  Val Val Gln Asp Phe  Asp Val Ser Leu Asn  Arg Val Arg 
    1025                 1030                 1035             


Ile Gly  Ala Ala Gln Phe Ser  Asp Thr Tyr His Pro  Glu Phe Pro 
    1040                 1045                 1050             


Leu Gly  Thr Phe Ile Gly Glu  Lys Glu Ile Ser Phe  Gln Ile Glu 
    1055                 1060                 1065             


Asn Ile  Lys Gln Ile Phe Gly  Asn Thr His Ile Gly  Ala Ala Leu 
    1070                 1075                 1080             


Arg Glu  Val Glu His Tyr Phe  Arg Pro Asp Met Gly  Ser Arg Ile 
    1085                 1090                 1095             


Asn Thr  Gly Thr Pro Gln Val  Leu Leu Val Leu Thr  Asp Gly Gln 
    1100                 1105                 1110             


Ser Gln  Asp Glu Val Ala Gln  Ala Ala Glu Ala Leu  Arg His Arg 
    1115                 1120                 1125             


Gly Ile  Asp Ile Tyr Ser Val  Gly Ile Gly Asp Val  Asp Asp Gln 
    1130                 1135                 1140             


Gln Leu  Ile Gln Ile Thr Gly  Thr Ala Glu Lys Lys  Leu Thr Val 
    1145                 1150                 1155             


His Asn  Phe Asp Glu Leu Lys  Lys Val Asn Lys Arg  Ile Val Arg 
    1160                 1165                 1170             


Asn Ile  Cys Thr Thr Ala Gly  Glu Ser Asn Cys Phe  Val Asp Val 
    1175                 1180                 1185             


Val Val  Gly Phe Asp Val Ser  Thr Gln Glu Lys Gly  Gln Thr Leu 
    1190                 1195                 1200             


Leu Glu  Gly Gln Pro Trp Met  Glu Thr Tyr Leu Gln  Asp Ile Leu 
    1205                 1210                 1215             


Arg Ala  Ile Ser Ser Leu Asn  Gly Val Ser Cys Glu  Val Gly Thr 
    1220                 1225                 1230             


Glu Thr  Gln Val Ser Val Ala  Phe Gln Val Thr Asn  Ala Met Glu 
    1235                 1240                 1245             


Lys Tyr  Ser Pro Lys Phe Glu  Ile Tyr Ser Glu Asn  Ile Leu Asn 
    1250                 1255                 1260             


Ser Leu  Lys Asp Ile Thr Val  Lys Gly Pro Ser Leu  Leu Asn Ala 
    1265                 1270                 1275             


Asn Leu  Leu Asp Ser Leu Trp  Asp Thr Phe Gln Asn  Lys Ser Ala 
    1280                 1285                 1290             


Ala Arg  Gly Lys Val Val Leu  Leu Phe Ser Asp Gly  Leu Asp Asp 
    1295                 1300                 1305             


Asp Val  Glu Lys Leu Glu Gln  Lys Ser Asp Glu Leu  Arg Lys Glu 
    1310                 1315                 1320             


Gly Leu  Asn Ala Leu Ile Thr  Val Ala Leu Asp Gly  Pro Ala Asp 
    1325                 1330                 1335             


Ser Ser  Asp Leu Ala Asp Leu  Pro Tyr Ile Glu Phe  Gly Lys Gly 
    1340                 1345                 1350             


Phe Glu  Tyr Arg Thr Gln Leu  Ser Ile Gly Met Arg  Glu Leu Gly 
    1355                 1360                 1365             


Ser Arg  Leu Ser Lys Gln Leu  Val Asn Val Ala Glu  Arg Thr Cys 
    1370                 1375                 1380             


Cys Cys  Leu Phe Cys Lys Cys  Ile Gly Gly Asp Gly  Thr Met Gly 
    1385                 1390                 1395             


Asp Pro  Gly Pro Pro Gly Lys  Arg Gly Pro Pro Gly  Phe Lys Gly 
    1400                 1405                 1410             


Ser Glu  Gly Tyr Leu Gly Glu  Glu Gly Ile Ala Gly  Glu Arg Gly 
    1415                 1420                 1425             


Ala Pro  Gly Pro Val Gly Glu  Gln Gly Thr Lys Gly  Cys Tyr Gly 
    1430                 1435                 1440             


Thr Lys  Gly Pro Lys Gly Asn  Arg Gly Leu Asn Gly  Gln Glu Gly 
    1445                 1450                 1455             


Glu Val  Gly Glu Asn Gly Ile  Asp Gly Leu Asn Gly  Glu Gln Gly 
    1460                 1465                 1470             


Asp Asn  Gly Leu Pro Gly Arg  Lys Gly Glu Lys Gly  Asp Glu Gly 
    1475                 1480                 1485             


Ser Gln  Gly Ser Pro Gly Lys  Arg Gly Thr Pro Gly  Asp Arg Gly 
    1490                 1495                 1500             


Ala Lys  Gly Leu Arg Gly Asp  Pro Gly Ala Pro Gly  Val Asp Ser 
    1505                 1510                 1515             


Ser Ile  Glu Gly Pro Thr Gly  Leu Lys Gly Glu Arg  Gly Arg Gln 
    1520                 1525                 1530             


Gly Arg  Arg Gly Trp Pro Gly  Pro Pro Gly Thr Pro  Gly Ser Arg 
    1535                 1540                 1545             


Arg Lys  Thr Ala Ala His Gly  Arg Arg Gly His Thr  Gly Pro Gln 
    1550                 1555                 1560             


Gly Thr  Ala Gly Ile Pro Gly  Pro Asp Gly Leu Glu  Gly Ser Leu 
    1565                 1570                 1575             


Gly Leu  Lys Gly Pro Gln Gly  Pro Arg Gly Glu Ala  Gly Val Lys 
    1580                 1585                 1590             


Gly Glu  Lys Gly Gly Val Gly  Ser Lys Gly Pro Gln  Gly Pro Pro 
    1595                 1600                 1605             


Gly Pro  Gly Gly Glu Ala Gly  Asn Gln Gly Arg Leu  Gly Ser Gln 
    1610                 1615                 1620             


Gly Asn  Lys Gly Glu Pro Gly  Asp Leu Gly Glu Lys  Gly Ala Val 
    1625                 1630                 1635             


Gly Phe  Pro Gly Pro Arg Gly  Leu Gln Gly Asn Asp  Gly Ser Pro 
    1640                 1645                 1650             


Gly Tyr  Gly Ser Val Gly Arg  Lys Gly Ala Lys Gly  Gln Glu Gly 
    1655                 1660                 1665             


Phe Pro  Gly Glu Ser Gly Pro  Lys Gly Glu Ile Gly  Asp Pro Gly 
    1670                 1675                 1680             


Gly Pro  Gly Glu Thr Gly Leu  Lys Gly Ala Arg Gly  Lys Met Ile 
    1685                 1690                 1695             


Ser Ala  Gly Leu Pro Gly Glu  Met Gly Ser Pro Gly  Glu Pro Gly 
    1700                 1705                 1710             


Pro Pro  Gly Arg Lys Gly Val  Lys Gly Ala Lys Gly  Leu Ala Ser 
    1715                 1720                 1725             


Phe Ser  Thr Cys Glu Leu Ile  Gln Tyr Val Arg Asp  Arg Ser Pro 
    1730                 1735                 1740             


Gly Arg  His Gly Lys Pro Glu  Cys Pro Val His Pro  Thr Glu Leu 
    1745                 1750                 1755             


Val Phe  Ala Leu Asp His Ser  Arg Asp Val Thr Glu  Gln Glu Phe 
    1760                 1765                 1770             


Glu Arg  Met Lys Glu Met Met  Ala Phe Leu Val Arg  Asp Ile Lys 
    1775                 1780                 1785             


Val Arg  Glu Asn Ser Cys Pro  Val Gly Ala His Ile  Ala Ile Leu 
    1790                 1795                 1800             


Ser Tyr  Asn Ser His Ala Arg  His Leu Val Arg Phe  Ser Asp Ala 
    1805                 1810                 1815             


Tyr Lys  Lys Ser Gln Leu Leu  Arg Glu Ile Glu Thr  Ile Pro Tyr 
    1820                 1825                 1830             


Glu Arg  Ser Ser Ala Ser Arg  Glu Ile Gly Arg Ala  Met Arg Phe 
    1835                 1840                 1845             


Ile Ser  Arg Asn Val Phe Lys  Arg Thr Leu Pro Gly  Ala His Thr 
    1850                 1855                 1860             


Arg Lys  Ile Ala Thr Phe Phe  Ser Ser Gly Gln Ser  Ala Asp Ala 
    1865                 1870                 1875             


His Ser  Ile Thr Thr Ala Ala  Met Glu Phe Gly Ala  Leu Glu Ile 
    1880                 1885                 1890             


Ile Pro  Val Val Ile Thr Phe  Ser Asn Val Pro Ser  Val Arg Arg 
    1895                 1900                 1905             


Ala Phe  Ala Ile Asp Asp Thr  Gly Thr Phe Gln Val  Ile Val Val 
    1910                 1915                 1920             


Pro Ser  Gly Ala Asp Tyr Ile  Pro Ala Leu Glu Arg  Leu Gln Arg 
    1925                 1930                 1935             


Cys Thr  Phe Cys Tyr Asp Val  Cys Lys Pro Asp Ala  Ser Cys Asp 
    1940                 1945                 1950             


Gln Ala  Arg Pro Pro Pro Val  Gln Ser Tyr Met Asp  Ala Ala Phe 
    1955                 1960                 1965             


Leu Leu  Asp Ala Ser Arg Asn  Met Gly Ser Ala Glu  Phe Glu Asp 
    1970                 1975                 1980             


Ile Arg  Ala Phe Leu Gly Ala  Leu Leu Asp His Phe  Glu Ile Thr 
    1985                 1990                 1995             


Pro Glu  Pro Glu Thr Ser Val  Thr Gly Asp Arg Val  Ala Leu Leu 
    2000                 2005                 2010             


Ser His  Ala Pro Pro Asp Phe  Leu Pro Asn Thr Gln  Lys Ser Pro 
    2015                 2020                 2025             


Val Arg  Ala Glu Phe Asn Leu  Thr Thr Tyr Arg Ser  Lys Arg Leu 
    2030                 2035                 2040             


Met Lys  Arg His Val His Glu  Ser Val Lys Gln Leu  Asn Gly Asp 
    2045                 2050                 2055             


Ala Phe  Ile Gly His Ala Leu  Gln Trp Thr Leu Asp  Asn Val Phe 
    2060                 2065                 2070             


Leu Ser  Thr Pro Asn Leu Arg  Arg Asn Lys Val Ile  Phe Val Ile 
    2075                 2080                 2085             


Ser Ala  Gly Glu Thr Ser His  Leu Asp Gly Glu Ile  Leu Lys Lys 
    2090                 2095                 2100             


Glu Ser  Leu Arg Ala Lys Cys  Gln Gly Tyr Ala Leu  Phe Val Phe 
    2105                 2110                 2115             


Ser Leu  Gly Pro Ile Trp Asp  Asp Lys Glu Leu Glu  Asp Leu Ala 
    2120                 2125                 2130             


Ser His  Pro Leu Asp His His  Leu Val Gln Leu Gly  Arg Ile His 
    2135                 2140                 2145             


Lys Pro  Asp His Ser Tyr Gly  Val Lys Phe Val Lys  Ser Phe Ile 
    2150                 2155                 2160             


Asn Ser  Ile Arg Arg Ala Ile  Asn Lys Tyr Pro Pro  Ile Asn Leu 
    2165                 2170                 2175             


Lys Ile  Lys Cys Asn Arg Leu  Asn Ser Ile Asp Pro  Lys Gln Pro 
    2180                 2185                 2190             


Pro Arg  Pro Phe Arg Ser Phe  Val Pro Gly Pro Leu  Lys Ala Thr 
    2195                 2200                 2205             


Leu Lys  Glu Asp Val Leu Gln  Lys Ala Lys Phe Phe  Gln Asp Lys 
    2210                 2215                 2220             


Lys Tyr  Leu Ser Arg Val Ala  Arg Ser Gly Arg Asp  Asp Ala Ile 
    2225                 2230                 2235             


Gln Asn  Phe Met Arg Ser Thr  Ser His Thr Phe Lys  Asn Gly Arg 
    2240                 2245                 2250             


Met Ile  Glu Ser Ala Pro Lys  Gln His Asp 
    2255                 2260             


<210>  26
<211>  3063
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Arg Ser Arg Leu Pro Pro Ala Leu Ala Ala Leu Gly Ala Ala Leu 
1               5                   10                  15      


Leu Leu Ser Ser Ile Glu Ala Glu Val Asp Pro Pro Ser Asp Leu Asn 
            20                  25                  30          


Phe Lys Ile Ile Asp Glu Asn Thr Val His Met Ser Trp Ala Lys Pro 
        35                  40                  45              


Val Asp Pro Ile Val Gly Tyr Arg Ile Thr Val Asp Pro Thr Thr Asp 
    50                  55                  60                  


Gly Pro Thr Lys Glu Phe Thr Leu Ser Ala Ser Thr Thr Glu Thr Leu 
65                  70                  75                  80  


Leu Ser Glu Leu Val Pro Glu Thr Glu Tyr Val Val Thr Ile Thr Ser 
                85                  90                  95      


Tyr Asp Glu Val Glu Glu Ser Val Pro Val Ile Gly Gln Leu Thr Ile 
            100                 105                 110         


Gln Thr Gly Ser Ser Thr Lys Pro Val Glu Lys Lys Pro Gly Lys Thr 
        115                 120                 125             


Glu Ile Gln Lys Cys Ser Val Ser Ala Trp Thr Asp Leu Val Phe Leu 
    130                 135                 140                 


Val Asp Gly Ser Trp Ser Val Gly Arg Asn Asn Phe Lys Tyr Ile Leu 
145                 150                 155                 160 


Asp Phe Ile Ala Ala Leu Val Ser Ala Phe Asp Ile Gly Glu Glu Lys 
                165                 170                 175     


Thr Arg Val Gly Val Val Gln Tyr Ser Ser Asp Thr Arg Thr Glu Phe 
            180                 185                 190         


Asn Leu Asn Gln Tyr Tyr Gln Arg Asp Glu Leu Leu Ala Ala Ile Lys 
        195                 200                 205             


Lys Ile Pro Tyr Lys Gly Gly Asn Thr Met Thr Gly Asp Ala Ile Asp 
    210                 215                 220                 


Tyr Leu Val Lys Asn Thr Phe Thr Glu Ser Ala Gly Ala Arg Val Gly 
225                 230                 235                 240 


Phe Pro Lys Val Ala Ile Ile Ile Thr Asp Gly Lys Ser Gln Asp Glu 
                245                 250                 255     


Val Glu Ile Pro Ala Arg Glu Leu Arg Asn Val Gly Val Glu Val Phe 
            260                 265                 270         


Ser Leu Gly Ile Lys Ala Ala Asp Ala Lys Glu Leu Lys Gln Ile Ala 
        275                 280                 285             


Ser Thr Pro Ser Leu Asn His Val Phe Asn Val Ala Asn Phe Asp Ala 
    290                 295                 300                 


Ile Val Asp Ile Gln Asn Glu Ile Ile Ser Gln Val Cys Ser Gly Val 
305                 310                 315                 320 


Asp Glu Gln Leu Gly Glu Leu Val Ser Gly Glu Glu Val Val Glu Pro 
                325                 330                 335     


Pro Ser Asn Leu Ile Ala Met Glu Val Ser Ser Lys Tyr Val Lys Leu 
            340                 345                 350         


Asn Trp Asn Pro Ser Pro Ser Pro Val Thr Gly Tyr Lys Val Ile Leu 
        355                 360                 365             


Thr Pro Met Thr Ala Gly Ser Arg Gln His Ala Leu Ser Val Gly Pro 
    370                 375                 380                 


Gln Thr Thr Thr Leu Ser Val Arg Asp Leu Ser Ala Asp Thr Glu Tyr 
385                 390                 395                 400 


Gln Ile Ser Val Ser Ala Met Lys Gly Met Thr Ser Ser Glu Pro Ile 
                405                 410                 415     


Ser Ile Met Glu Lys Thr Gln Pro Met Lys Val Gln Val Glu Cys Ser 
            420                 425                 430         


Arg Gly Val Asp Ile Lys Ala Asp Ile Val Phe Leu Val Asp Gly Ser 
        435                 440                 445             


Tyr Ser Ile Gly Ile Ala Asn Phe Val Lys Val Arg Ala Phe Leu Glu 
    450                 455                 460                 


Val Leu Val Lys Ser Phe Glu Ile Ser Pro Asn Arg Val Gln Ile Ser 
465                 470                 475                 480 


Leu Val Gln Tyr Ser Arg Asp Pro His Thr Glu Phe Thr Leu Lys Lys 
                485                 490                 495     


Phe Thr Lys Val Glu Asp Ile Ile Glu Ala Ile Asn Thr Phe Pro Tyr 
            500                 505                 510         


Arg Gly Gly Ser Thr Asn Thr Gly Lys Ala Met Thr Tyr Val Arg Glu 
        515                 520                 525             


Lys Ile Phe Val Pro Ser Lys Gly Ser Arg Ser Asn Val Pro Lys Val 
    530                 535                 540                 


Met Ile Leu Ile Thr Asp Gly Lys Ser Ser Asp Ala Phe Arg Asp Pro 
545                 550                 555                 560 


Ala Ile Lys Leu Arg Asn Ser Asp Val Glu Ile Phe Ala Val Gly Val 
                565                 570                 575     


Lys Asp Ala Val Arg Ser Glu Leu Glu Ala Ile Ala Ser Pro Pro Ala 
            580                 585                 590         


Glu Thr His Val Phe Thr Val Glu Asp Phe Asp Ala Phe Gln Arg Ile 
        595                 600                 605             


Ser Phe Glu Leu Thr Gln Ser Ile Cys Leu Arg Ile Glu Gln Glu Leu 
    610                 615                 620                 


Ala Ala Ile Lys Lys Lys Ala Tyr Val Pro Pro Lys Asp Leu Ser Phe 
625                 630                 635                 640 


Ser Glu Val Thr Ser Tyr Gly Phe Lys Thr Asn Trp Ser Pro Ala Gly 
                645                 650                 655     


Glu Asn Val Phe Ser Tyr His Ile Thr Tyr Lys Glu Ala Ala Gly Asp 
            660                 665                 670         


Asp Glu Val Thr Val Val Glu Pro Ala Ser Ser Thr Ser Val Val Leu 
        675                 680                 685             


Ser Ser Leu Lys Pro Glu Thr Leu Tyr Leu Val Asn Val Thr Ala Glu 
    690                 695                 700                 


Tyr Glu Asp Gly Phe Ser Ile Pro Leu Ala Gly Glu Glu Thr Thr Glu 
705                 710                 715                 720 


Glu Val Lys Gly Ala Pro Arg Asn Leu Lys Val Thr Asp Glu Thr Thr 
                725                 730                 735     


Asp Ser Phe Lys Ile Thr Trp Thr Gln Ala Pro Gly Arg Val Leu Arg 
            740                 745                 750         


Tyr Arg Ile Ile Tyr Arg Pro Val Ala Gly Gly Glu Ser Arg Glu Val 
        755                 760                 765             


Thr Thr Pro Pro Asn Gln Arg Arg Arg Thr Leu Glu Asn Leu Ile Pro 
    770                 775                 780                 


Asp Thr Lys Tyr Glu Val Ser Val Ile Pro Glu Tyr Phe Ser Gly Pro 
785                 790                 795                 800 


Gly Thr Pro Leu Thr Gly Asn Ala Ala Thr Glu Glu Val Arg Gly Asn 
                805                 810                 815     


Pro Arg Asp Leu Arg Val Ser Asp Pro Thr Thr Ser Thr Met Lys Leu 
            820                 825                 830         


Ser Trp Ser Gly Ala Pro Gly Lys Val Lys Gln Tyr Leu Val Thr Tyr 
        835                 840                 845             


Thr Pro Val Ala Gly Gly Glu Thr Gln Glu Val Thr Val Arg Gly Asp 
    850                 855                 860                 


Thr Thr Asn Thr Val Leu Gln Gly Leu Lys Glu Gly Thr Gln Tyr Ala 
865                 870                 875                 880 


Leu Ser Val Thr Ala Leu Tyr Ala Ser Gly Ala Gly Asp Ala Leu Phe 
                885                 890                 895     


Gly Glu Gly Thr Thr Leu Glu Glu Arg Gly Ser Pro Gln Asp Leu Val 
            900                 905                 910         


Thr Lys Asp Ile Thr Asp Thr Ser Ile Gly Ala Tyr Trp Thr Ser Ala 
        915                 920                 925             


Pro Gly Met Val Arg Gly Tyr Arg Val Ser Trp Lys Ser Leu Tyr Asp 
    930                 935                 940                 


Asp Val Asp Thr Gly Glu Lys Asn Leu Pro Glu Asp Ala Ile His Thr 
945                 950                 955                 960 


Met Ile Glu Asn Leu Gln Pro Glu Thr Lys Tyr Arg Ile Ser Val Phe 
                965                 970                 975     


Ala Thr Tyr Ser Ser Gly Glu Gly Glu Pro Leu Thr Gly Asp Ala Thr 
            980                 985                 990         


Thr Glu Leu Ser Gln Asp Ser Lys  Thr Leu Lys Val Asp  Glu Glu Thr 
        995                 1000                 1005             


Glu Asn  Thr Met Arg Val Thr  Trp Lys Pro Ala Pro  Gly Lys Val 
    1010                 1015                 1020             


Val Asn  Tyr Arg Val Val Tyr  Arg Pro His Gly Arg  Gly Lys Gln 
    1025                 1030                 1035             


Met Val  Ala Lys Val Pro Pro  Thr Val Thr Ser Thr  Val Leu Lys 
    1040                 1045                 1050             


Arg Leu  Gln Pro Gln Thr Thr  Tyr Asp Ile Thr Val  Leu Pro Ile 
    1055                 1060                 1065             


Tyr Lys  Met Gly Glu Gly Lys  Leu Arg Gln Gly Ser  Gly Thr Thr 
    1070                 1075                 1080             


Ala Ser  Arg Phe Lys Ser Pro  Arg Asn Leu Lys Thr  Ser Asp Pro 
    1085                 1090                 1095             


Thr Met  Ser Ser Phe Arg Val  Thr Trp Glu Pro Ala  Pro Gly Glu 
    1100                 1105                 1110             


Val Lys  Gly Tyr Lys Val Thr  Phe His Pro Thr Gly  Asp Asp Arg 
    1115                 1120                 1125             


Arg Leu  Gly Glu Leu Val Val  Gly Pro Tyr Asp Asn  Thr Val Val 
    1130                 1135                 1140             


Leu Glu  Glu Leu Arg Ala Gly  Thr Thr Tyr Lys Val  Asn Val Phe 
    1145                 1150                 1155             


Gly Met  Phe Asp Gly Gly Glu  Ser Ser Pro Leu Val  Gly Gln Glu 
    1160                 1165                 1170             


Met Thr  Thr Leu Ser Asp Thr  Thr Val Met Pro Ile  Leu Ser Ser 
    1175                 1180                 1185             


Gly Met  Glu Cys Leu Thr Arg  Ala Glu Ala Asp Ile  Val Leu Leu 
    1190                 1195                 1200             


Val Asp  Gly Ser Trp Ser Ile  Gly Arg Ala Asn Phe  Arg Thr Val 
    1205                 1210                 1215             


Arg Ser  Phe Ile Ser Arg Ile  Val Glu Val Phe Asp  Ile Gly Pro 
    1220                 1225                 1230             


Lys Arg  Val Gln Ile Ala Leu  Ala Gln Tyr Ser Gly  Asp Pro Arg 
    1235                 1240                 1245             


Thr Glu  Trp Gln Leu Asn Ala  His Arg Asp Lys Lys  Ser Leu Leu 
    1250                 1255                 1260             


Gln Ala  Val Ala Asn Leu Pro  Tyr Lys Gly Gly Asn  Thr Leu Thr 
    1265                 1270                 1275             


Gly Met  Ala Leu Asn Phe Ile  Arg Gln Gln Asn Phe  Arg Thr Gln 
    1280                 1285                 1290             


Ala Gly  Met Arg Pro Arg Ala  Arg Lys Ile Gly Val  Leu Ile Thr 
    1295                 1300                 1305             


Asp Gly  Lys Ser Gln Asp Asp  Val Glu Ala Pro Ser  Lys Lys Leu 
    1310                 1315                 1320             


Lys Asp  Glu Gly Val Glu Leu  Phe Ala Ile Gly Ile  Lys Asn Ala 
    1325                 1330                 1335             


Asp Glu  Val Glu Leu Lys Met  Ile Ala Thr Asp Pro  Asp Asp Thr 
    1340                 1345                 1350             


His Ala  Tyr Asn Val Ala Asp  Phe Glu Ser Leu Ser  Arg Ile Val 
    1355                 1360                 1365             


Asp Asp  Leu Thr Ile Asn Leu  Cys Asn Ser Val Lys  Gly Pro Gly 
    1370                 1375                 1380             


Asp Leu  Glu Ala Pro Ser Asn  Leu Val Ile Ser Glu  Arg Thr His 
    1385                 1390                 1395             


Arg Ser  Phe Arg Val Ser Trp  Thr Pro Pro Ser Asp  Ser Val Asp 
    1400                 1405                 1410             


Arg Tyr  Lys Val Glu Tyr Tyr  Pro Val Ser Gly Gly  Lys Arg Gln 
    1415                 1420                 1425             


Glu Phe  Tyr Val Ser Arg Met  Glu Thr Ser Thr Val  Leu Lys Asp 
    1430                 1435                 1440             


Leu Lys  Pro Glu Thr Glu Tyr  Val Val Asn Val Tyr  Ser Val Val 
    1445                 1450                 1455             


Glu Asp  Glu Tyr Ser Glu Pro  Leu Lys Gly Thr Glu  Lys Thr Leu 
    1460                 1465                 1470             


Pro Val  Pro Val Val Ser Leu  Asn Ile Tyr Asp Val  Gly Pro Thr 
    1475                 1480                 1485             


Thr Met  His Val Gln Trp Gln  Pro Val Gly Gly Ala  Thr Gly Tyr 
    1490                 1495                 1500             


Ile Leu  Ser Tyr Lys Pro Val  Lys Asp Thr Glu Pro  Thr Arg Pro 
    1505                 1510                 1515             


Lys Glu  Val Arg Leu Gly Pro  Thr Val Asn Asp Met  Gln Leu Thr 
    1520                 1525                 1530             


Asp Leu  Val Pro Asn Thr Glu  Tyr Ala Val Thr Val  Gln Ala Val 
    1535                 1540                 1545             


Leu His  Asp Leu Thr Ser Glu  Pro Val Thr Val Arg  Glu Val Thr 
    1550                 1555                 1560             


Leu Pro  Leu Pro Arg Pro Gln  Asp Leu Lys Leu Arg  Asp Val Thr 
    1565                 1570                 1575             


His Ser  Thr Met Asn Val Phe  Trp Glu Pro Val Pro  Gly Lys Val 
    1580                 1585                 1590             


Arg Lys  Tyr Ile Val Arg Tyr  Lys Thr Pro Glu Glu  Asp Val Lys 
    1595                 1600                 1605             


Glu Val  Glu Val Asp Arg Ser  Glu Thr Ser Thr Ser  Leu Lys Asp 
    1610                 1615                 1620             


Leu Phe  Ser Gln Thr Leu Tyr  Thr Val Ser Val Ser  Ala Val His 
    1625                 1630                 1635             


Asp Glu  Gly Glu Ser Pro Pro  Val Thr Ala Gln Glu  Thr Thr Arg 
    1640                 1645                 1650             


Pro Val  Pro Ala Pro Thr Asn  Leu Lys Ile Thr Glu  Val Thr Ser 
    1655                 1660                 1665             


Glu Gly  Phe Arg Gly Thr Trp  Asp His Gly Ala Ser  Asp Val Ser 
    1670                 1675                 1680             


Leu Tyr  Arg Ile Thr Trp Ala  Pro Phe Gly Ser Ser  Asp Lys Met 
    1685                 1690                 1695             


Glu Thr  Ile Leu Asn Gly Asp  Glu Asn Thr Leu Val  Phe Glu Asn 
    1700                 1705                 1710             


Leu Asn  Pro Asn Thr Ile Tyr  Glu Val Ser Ile Thr  Ala Ile Tyr 
    1715                 1720                 1725             


Pro Asp  Glu Ser Glu Ser Asp  Asp Leu Ile Gly Ser  Glu Arg Thr 
    1730                 1735                 1740             


Leu Pro  Ile Leu Thr Thr Gln  Ala Pro Lys Ser Gly  Pro Arg Asn 
    1745                 1750                 1755             


Leu Gln  Val Tyr Asn Ala Thr  Ser Asn Ser Leu Thr  Val Lys Trp 
    1760                 1765                 1770             


Asp Pro  Ala Ser Gly Arg Val  Gln Lys Tyr Arg Ile  Thr Tyr Gln 
    1775                 1780                 1785             


Pro Ser  Thr Gly Glu Gly Asn  Glu Gln Thr Thr Thr  Ile Gly Gly 
    1790                 1795                 1800             


Arg Gln  Asn Ser Val Val Leu  Gln Lys Leu Lys Pro  Asp Thr Pro 
    1805                 1810                 1815             


Tyr Thr  Ile Thr Val Ser Ser  Leu Tyr Pro Asp Gly  Glu Gly Gly 
    1820                 1825                 1830             


Arg Met  Thr Gly Arg Gly Lys  Thr Lys Pro Leu Asn  Thr Val Arg 
    1835                 1840                 1845             


Asn Leu  Arg Val Tyr Asp Pro  Ser Thr Ser Thr Leu  Asn Val Arg 
    1850                 1855                 1860             


Trp Asp  His Ala Glu Gly Asn  Pro Arg Gln Tyr Lys  Leu Phe Tyr 
    1865                 1870                 1875             


Ala Pro  Ala Ala Gly Gly Pro  Glu Glu Leu Val Pro  Ile Pro Gly 
    1880                 1885                 1890             


Asn Thr  Asn Tyr Ala Ile Leu  Arg Asn Leu Gln Pro  Asp Thr Ser 
    1895                 1900                 1905             


Tyr Thr  Val Thr Val Val Pro  Val Tyr Thr Glu Gly  Asp Gly Gly 
    1910                 1915                 1920             


Arg Thr  Ser Asp Thr Gly Arg  Thr Leu Met Arg Gly  Leu Ala Arg 
    1925                 1930                 1935             


Asn Val  Gln Val Tyr Asn Pro  Thr Pro Asn Ser Leu  Asp Val Arg 
    1940                 1945                 1950             


Trp Asp  Pro Ala Pro Gly Pro  Val Leu Gln Tyr Arg  Val Val Tyr 
    1955                 1960                 1965             


Ser Pro  Val Asp Gly Thr Arg  Pro Ser Glu Ser Ile  Val Val Pro 
    1970                 1975                 1980             


Gly Asn  Thr Arg Met Val His  Leu Glu Arg Leu Ile  Pro Asp Thr 
    1985                 1990                 1995             


Leu Tyr  Ser Val Asn Leu Val  Ala Leu Tyr Ser Asp  Gly Glu Gly 
    2000                 2005                 2010             


Asn Pro  Ser Pro Ala Gln Gly  Arg Thr Leu Pro Arg  Ser Gly Pro 
    2015                 2020                 2025             


Arg Asn  Leu Arg Val Phe Gly  Glu Thr Thr Asn Ser  Leu Ser Val 
    2030                 2035                 2040             


Ala Trp  Asp His Ala Asp Gly  Pro Val Gln Gln Tyr  Arg Ile Ile 
    2045                 2050                 2055             


Tyr Ser  Pro Thr Val Gly Asp  Pro Ile Asp Glu Tyr  Thr Thr Val 
    2060                 2065                 2070             


Pro Gly  Arg Arg Asn Asn Val  Ile Leu Gln Pro Leu  Gln Pro Asp 
    2075                 2080                 2085             


Thr Pro  Tyr Lys Ile Thr Val  Ile Ala Val Tyr Glu  Asp Gly Asp 
    2090                 2095                 2100             


Gly Gly  His Leu Thr Gly Asn  Gly Arg Thr Val Gly  Leu Leu Pro 
    2105                 2110                 2115             


Pro Gln  Asn Ile His Ile Ser  Asp Glu Trp Tyr Thr  Arg Phe Arg 
    2120                 2125                 2130             


Val Ser  Trp Asp Pro Ser Pro  Ser Pro Val Leu Gly  Tyr Lys Ile 
    2135                 2140                 2145             


Val Tyr  Lys Pro Val Gly Ser  Asn Glu Pro Met Glu  Ala Phe Val 
    2150                 2155                 2160             


Gly Glu  Met Thr Ser Tyr Thr  Leu His Asn Leu Asn  Pro Ser Thr 
    2165                 2170                 2175             


Thr Tyr  Asp Val Asn Val Tyr  Ala Gln Tyr Asp Ser  Gly Leu Ser 
    2180                 2185                 2190             


Val Pro  Leu Thr Asp Gln Gly  Thr Thr Leu Tyr Leu  Asn Val Thr 
    2195                 2200                 2205             


Asp Leu  Lys Thr Tyr Gln Ile  Gly Trp Asp Thr Phe  Cys Val Lys 
    2210                 2215                 2220             


Trp Ser  Pro His Arg Ala Ala  Thr Ser Tyr Arg Leu  Lys Leu Ser 
    2225                 2230                 2235             


Pro Ala  Asp Gly Thr Arg Gly  Gln Glu Ile Thr Val  Arg Gly Ser 
    2240                 2245                 2250             


Glu Thr  Ser His Cys Phe Thr  Gly Leu Ser Pro Asp  Thr Asp Tyr 
    2255                 2260                 2265             


Gly Val  Thr Val Phe Val Gln  Thr Pro Asn Leu Glu  Gly Pro Gly 
    2270                 2275                 2280             


Val Ser  Val Lys Glu His Thr  Thr Val Lys Pro Thr  Glu Ala Pro 
    2285                 2290                 2295             


Thr Glu  Pro Pro Thr Pro Pro  Pro Pro Pro Thr Ile  Pro Pro Ala 
    2300                 2305                 2310             


Arg Asp  Val Cys Lys Gly Ala  Lys Ala Asp Ile Val  Phe Leu Thr 
    2315                 2320                 2325             


Asp Ala  Ser Trp Ser Ile Gly  Asp Asp Asn Phe Asn  Lys Val Val 
    2330                 2335                 2340             


Lys Phe  Ile Phe Asn Thr Val  Gly Gly Phe Asp Glu  Ile Ser Pro 
    2345                 2350                 2355             


Ala Gly  Ile Gln Val Ser Phe  Val Gln Tyr Ser Asp  Glu Val Lys 
    2360                 2365                 2370             


Ser Glu  Phe Lys Leu Asn Thr  Tyr Asn Asp Lys Ala  Leu Ala Leu 
    2375                 2380                 2385             


Gly Ala  Leu Gln Asn Ile Arg  Tyr Arg Gly Gly Asn  Thr Arg Thr 
    2390                 2395                 2400             


Gly Lys  Ala Leu Thr Phe Ile  Lys Glu Lys Val Leu  Thr Trp Glu 
    2405                 2410                 2415             


Ser Gly  Met Arg Lys Asn Val  Pro Lys Val Leu Val  Val Val Thr 
    2420                 2425                 2430             


Asp Gly  Arg Ser Gln Asp Glu  Val Lys Lys Ala Ala  Leu Val Ile 
    2435                 2440                 2445             


Gln Gln  Ser Gly Phe Ser Val  Phe Val Val Gly Val  Ala Asp Val 
    2450                 2455                 2460             


Asp Tyr  Asn Glu Leu Ala Asn  Ile Ala Ser Lys Pro  Ser Glu Arg 
    2465                 2470                 2475             


His Val  Phe Ile Val Asp Asp  Phe Glu Ser Phe Glu  Lys Ile Glu 
    2480                 2485                 2490             


Asp Asn  Leu Ile Thr Phe Val  Cys Glu Thr Ala Thr  Ser Ser Cys 
    2495                 2500                 2505             


Pro Leu  Ile Tyr Leu Asp Gly  Tyr Thr Ser Pro Gly  Phe Lys Met 
    2510                 2515                 2520             


Leu Glu  Ala Tyr Asn Leu Thr  Glu Lys Asn Phe Ala  Ser Val Gln 
    2525                 2530                 2535             


Gly Val  Ser Leu Glu Ser Gly  Ser Phe Pro Ser Tyr  Ser Ala Tyr 
    2540                 2545                 2550             


Arg Ile  Gln Lys Asn Ala Phe  Val Asn Gln Pro Thr  Ala Asp Leu 
    2555                 2560                 2565             


His Pro  Asn Gly Leu Pro Pro  Ser Tyr Thr Ile Ile  Leu Leu Phe 
    2570                 2575                 2580             


Arg Leu  Leu Pro Glu Thr Pro  Ser Asp Pro Phe Ala  Ile Trp Gln 
    2585                 2590                 2595             


Ile Thr  Asp Arg Asp Tyr Lys  Pro Gln Val Gly Val  Ile Ala Asp 
    2600                 2605                 2610             


Pro Ser  Ser Lys Thr Leu Ser  Phe Phe Asn Lys Asp  Thr Arg Gly 
    2615                 2620                 2625             


Glu Val  Gln Thr Val Thr Phe  Asp Thr Glu Glu Val  Lys Thr Leu 
    2630                 2635                 2640             


Phe Tyr  Gly Ser Phe His Lys  Val His Ile Val Val  Thr Ser Lys 
    2645                 2650                 2655             


Ser Val  Lys Ile Tyr Ile Asp  Cys Tyr Glu Ile Ile  Glu Lys Asp 
    2660                 2665                 2670             


Ile Lys  Glu Ala Gly Asn Ile  Thr Thr Asp Gly Tyr  Glu Ile Leu 
    2675                 2680                 2685             


Gly Lys  Leu Leu Lys Gly Glu  Arg Lys Ser Ala Ala  Phe Gln Ile 
    2690                 2695                 2700             


Gln Ser  Phe Asp Ile Val Cys  Ser Pro Val Trp Thr  Ser Arg Asp 
    2705                 2710                 2715             


Arg Cys  Cys Asp Ile Pro Ser  Arg Arg Asp Glu Gly  Lys Cys Pro 
    2720                 2725                 2730             


Ala Phe  Pro Asn Ser Cys Thr  Cys Thr Gln Asp Ser  Val Gly Pro 
    2735                 2740                 2745             


Pro Gly  Pro Pro Gly Pro Ala  Gly Gly Pro Gly Ala  Lys Gly Pro 
    2750                 2755                 2760             


Arg Gly  Glu Arg Gly Ile Ser  Gly Ala Ile Gly Pro  Pro Gly Pro 
    2765                 2770                 2775             


Arg Gly  Asp Ile Gly Pro Pro  Gly Pro Gln Gly Pro  Pro Gly Pro 
    2780                 2785                 2790             


Gln Gly  Pro Asn Gly Leu Ser  Ile Pro Gly Glu Gln  Gly Arg Gln 
    2795                 2800                 2805             


Gly Met  Lys Gly Asp Ala Gly  Glu Pro Gly Leu Pro  Gly Arg Thr 
    2810                 2815                 2820             


Gly Thr  Pro Gly Leu Pro Gly  Pro Pro Gly Pro Met  Gly Pro Pro 
    2825                 2830                 2835             


Gly Asp  Arg Gly Phe Thr Gly  Lys Asp Gly Ala Met  Gly Pro Arg 
    2840                 2845                 2850             


Gly Pro  Pro Gly Pro Pro Gly  Ser Pro Gly Ser Pro  Gly Val Thr 
    2855                 2860                 2865             


Gly Pro  Ser Gly Lys Pro Gly  Lys Pro Gly Asp His  Gly Arg Pro 
    2870                 2875                 2880             


Gly Pro  Ser Gly Leu Lys Gly  Glu Lys Gly Asp Arg  Gly Asp Ile 
    2885                 2890                 2895             


Ala Ser  Gln Asn Met Met Arg  Ala Val Ala Arg Gln  Val Cys Glu 
    2900                 2905                 2910             


Gln Leu  Ile Ser Gly Gln Met  Asn Arg Phe Asn Gln  Met Leu Asn 
    2915                 2920                 2925             


Gln Ile  Pro Asn Asp Tyr Gln  Ser Ser Arg Asn Gln  Pro Gly Pro 
    2930                 2935                 2940             


Pro Gly  Pro Pro Gly Pro Pro  Gly Ser Ala Gly Ala  Arg Gly Glu 
    2945                 2950                 2955             


Pro Gly  Pro Gly Gly Arg Pro  Gly Phe Pro Gly Thr  Pro Gly Met 
    2960                 2965                 2970             


Gln Gly  Pro Pro Gly Glu Arg  Gly Leu Pro Gly Glu  Lys Gly Glu 
    2975                 2980                 2985             


Arg Gly  Thr Gly Ser Ser Gly  Pro Arg Gly Leu Pro  Gly Pro Pro 
    2990                 2995                 3000             


Gly Pro  Gln Gly Glu Ser Arg  Thr Gly Pro Pro Gly  Ser Thr Gly 
    3005                 3010                 3015             


Ser Arg  Gly Pro Pro Gly Pro  Pro Gly Arg Pro Gly  Asn Ser Gly 
    3020                 3025                 3030             


Ile Arg  Gly Pro Pro Gly Pro  Pro Gly Tyr Cys Asp  Ser Ser Gln 
    3035                 3040                 3045             


Cys Ala  Ser Ile Pro Tyr Asn  Gly Gln Gly Tyr Pro  Gly Ser Gly 
    3050                 3055                 3060             


<210>  27
<211>  1604
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Trp Val Ser Trp Ala Pro Gly Leu Trp Leu Leu Gly Leu Trp Ala 
1               5                   10                  15      


Thr Phe Gly His Gly Ala Asn Thr Gly Ala Gln Cys Pro Pro Ser Gln 
            20                  25                  30          


Gln Glu Gly Leu Lys Leu Glu His Ser Ser Ser Leu Pro Ala Asn Val 
        35                  40                  45              


Thr Gly Phe Asn Leu Ile His Arg Leu Ser Leu Met Lys Thr Ser Ala 
    50                  55                  60                  


Ile Lys Lys Ile Arg Asn Pro Lys Gly Pro Leu Ile Leu Arg Leu Gly 
65                  70                  75                  80  


Ala Ala Pro Val Thr Gln Pro Thr Arg Arg Val Phe Pro Arg Gly Leu 
                85                  90                  95      


Pro Glu Glu Phe Ala Leu Val Leu Thr Leu Leu Leu Lys Lys His Thr 
            100                 105                 110         


His Gln Lys Thr Trp Tyr Leu Phe Gln Val Thr Asp Ala Asn Gly Tyr 
        115                 120                 125             


Pro Gln Ile Ser Leu Glu Val Asn Ser Gln Glu Arg Ser Leu Glu Leu 
    130                 135                 140                 


Arg Ala Gln Gly Gln Asp Gly Asp Phe Val Ser Cys Ile Phe Pro Val 
145                 150                 155                 160 


Pro Gln Leu Phe Asp Leu Arg Trp His Lys Leu Met Leu Ser Val Ala 
                165                 170                 175     


Gly Arg Val Ala Ser Val His Val Asp Cys Ser Ser Ala Ser Ser Gln 
            180                 185                 190         


Pro Leu Gly Pro Arg Arg Pro Met Arg Pro Val Gly His Val Phe Leu 
        195                 200                 205             


Gly Leu Asp Ala Glu Gln Gly Lys Pro Val Ser Phe Asp Leu Gln Gln 
    210                 215                 220                 


Val His Ile Tyr Cys Asp Pro Glu Leu Val Leu Glu Glu Gly Cys Cys 
225                 230                 235                 240 


Glu Ile Leu Pro Ala Gly Cys Pro Pro Glu Thr Ser Lys Ala Arg Arg 
                245                 250                 255     


Asp Thr Gln Ser Asn Glu Leu Ile Glu Ile Asn Pro Gln Ser Glu Gly 
            260                 265                 270         


Lys Val Tyr Thr Arg Cys Phe Cys Leu Glu Glu Pro Gln Asn Ser Glu 
        275                 280                 285             


Val Asp Ala Gln Leu Thr Gly Arg Ile Ser Gln Lys Ala Glu Arg Gly 
    290                 295                 300                 


Ala Lys Val His Gln Glu Thr Ala Ala Asp Glu Cys Pro Pro Cys Val 
305                 310                 315                 320 


His Gly Ala Arg Asp Ser Asn Val Thr Leu Ala Pro Ser Gly Pro Lys 
                325                 330                 335     


Gly Gly Lys Gly Glu Arg Gly Leu Pro Gly Pro Pro Gly Ser Lys Gly 
            340                 345                 350         


Glu Lys Gly Ala Arg Gly Asn Asp Cys Val Arg Ile Ser Pro Asp Ala 
        355                 360                 365             


Pro Leu Gln Cys Ala Glu Gly Pro Lys Gly Glu Lys Gly Glu Ser Gly 
    370                 375                 380                 


Ala Leu Gly Pro Ser Gly Leu Pro Gly Ser Thr Gly Glu Lys Gly Gln 
385                 390                 395                 400 


Lys Gly Glu Lys Gly Asp Gly Gly Ile Lys Gly Val Pro Gly Lys Pro 
                405                 410                 415     


Gly Arg Asp Gly Arg Pro Gly Glu Ile Cys Val Ile Gly Pro Lys Gly 
            420                 425                 430         


Gln Lys Gly Asp Pro Gly Phe Val Gly Pro Glu Gly Leu Ala Gly Glu 
        435                 440                 445             


Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Ile Gly Leu Pro Gly 
    450                 455                 460                 


Thr Pro Gly Asp Pro Gly Gly Pro Pro Gly Pro Lys Gly Asp Lys Gly 
465                 470                 475                 480 


Ser Ser Gly Ile Pro Gly Lys Glu Gly Pro Gly Gly Lys Pro Gly Lys 
                485                 490                 495     


Pro Gly Val Lys Gly Glu Lys Gly Asp Pro Cys Glu Val Cys Pro Thr 
            500                 505                 510         


Leu Pro Glu Gly Phe Gln Asn Phe Val Gly Leu Pro Gly Lys Pro Gly 
        515                 520                 525             


Pro Lys Gly Glu Pro Gly Asp Pro Val Pro Ala Arg Gly Asp Pro Gly 
    530                 535                 540                 


Ile Gln Gly Ile Lys Gly Glu Lys Gly Glu Pro Cys Leu Ser Cys Ser 
545                 550                 555                 560 


Ser Val Val Gly Ala Gln His Leu Val Ser Ser Thr Gly Ala Ser Gly 
                565                 570                 575     


Asp Val Gly Ser Pro Gly Phe Gly Leu Pro Gly Leu Pro Gly Arg Ala 
            580                 585                 590         


Gly Val Pro Gly Leu Lys Gly Glu Lys Gly Asn Phe Gly Glu Ala Gly 
        595                 600                 605             


Pro Ala Gly Ser Pro Gly Pro Pro Gly Pro Val Gly Pro Ala Gly Ile 
    610                 615                 620                 


Lys Gly Ala Lys Gly Glu Pro Cys Glu Pro Cys Pro Ala Leu Ser Asn 
625                 630                 635                 640 


Leu Gln Asp Gly Asp Val Arg Val Val Ala Leu Pro Gly Pro Ser Gly 
                645                 650                 655     


Glu Lys Gly Glu Pro Gly Pro Pro Gly Phe Gly Leu Pro Gly Lys Gln 
            660                 665                 670         


Gly Lys Ala Gly Glu Arg Gly Leu Lys Gly Gln Lys Gly Asp Ala Gly 
        675                 680                 685             


Asn Pro Gly Asp Pro Gly Thr Pro Gly Thr Thr Gly Arg Pro Gly Leu 
    690                 695                 700                 


Ser Gly Glu Pro Gly Val Gln Gly Pro Ala Gly Pro Lys Gly Glu Lys 
705                 710                 715                 720 


Gly Asp Gly Cys Thr Ala Cys Pro Ser Leu Gln Gly Thr Val Thr Asp 
                725                 730                 735     


Met Ala Gly Arg Pro Gly Gln Pro Gly Pro Lys Gly Glu Gln Gly Pro 
            740                 745                 750         


Glu Gly Val Gly Arg Pro Gly Lys Pro Gly Gln Pro Gly Leu Pro Gly 
        755                 760                 765             


Val Gln Gly Pro Pro Gly Leu Lys Gly Val Gln Gly Glu Pro Gly Pro 
    770                 775                 780                 


Pro Gly Arg Gly Val Gln Gly Pro Gln Gly Glu Pro Gly Ala Pro Gly 
785                 790                 795                 800 


Leu Pro Gly Ile Gln Gly Leu Pro Gly Pro Arg Gly Pro Pro Gly Pro 
                805                 810                 815     


Thr Gly Glu Lys Gly Ala Gln Gly Ser Pro Gly Val Lys Gly Ala Thr 
            820                 825                 830         


Gly Pro Val Gly Pro Pro Gly Ala Ser Val Ser Gly Pro Pro Gly Arg 
        835                 840                 845             


Asp Gly Gln Gln Gly Gln Thr Gly Leu Arg Gly Thr Pro Gly Glu Lys 
    850                 855                 860                 


Gly Pro Arg Gly Glu Lys Gly Glu Pro Gly Glu Cys Ser Cys Pro Ser 
865                 870                 875                 880 


Gln Gly Asp Leu Ile Phe Ser Gly Met Pro Gly Ala Pro Gly Leu Trp 
                885                 890                 895     


Met Gly Ser Ser Trp Gln Pro Gly Pro Gln Gly Pro Pro Gly Ile Pro 
            900                 905                 910         


Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Leu Gln Gly Val Pro Gly 
        915                 920                 925             


Asn Asn Gly Leu Pro Gly Gln Pro Gly Leu Thr Ala Glu Leu Gly Ser 
    930                 935                 940                 


Leu Pro Ile Glu Gln His Leu Leu Lys Ser Ile Cys Gly Asp Cys Val 
945                 950                 955                 960 


Gln Gly Gln Arg Ala His Pro Gly Tyr Leu Val Glu Lys Gly Glu Lys 
                965                 970                 975     


Gly Asp Gln Gly Ile Pro Gly Val Pro Gly Leu Asp Asn Cys Ala Gln 
            980                 985                 990         


Cys Phe Leu Ser Leu Glu Arg Pro  Arg Ala Glu Glu Ala  Arg Gly Asp 
        995                 1000                 1005             


Asn Ser  Glu Gly Asp Pro Gly  Cys Val Gly Ser Pro  Gly Leu Pro 
    1010                 1015                 1020             


Gly Pro  Pro Gly Leu Pro Gly  Gln Arg Gly Glu Glu  Gly Pro Pro 
    1025                 1030                 1035             


Gly Met  Arg Gly Ser Pro Gly  Pro Pro Gly Pro Ile  Gly Pro Pro 
    1040                 1045                 1050             


Gly Phe  Pro Gly Ala Val Gly  Ser Pro Gly Leu Pro  Gly Leu Gln 
    1055                 1060                 1065             


Gly Glu  Arg Gly Leu Thr Gly  Leu Thr Gly Asp Lys  Gly Glu Pro 
    1070                 1075                 1080             


Gly Pro  Pro Gly Gln Pro Gly  Tyr Pro Gly Ala Thr  Gly Pro Pro 
    1085                 1090                 1095             


Gly Leu  Pro Gly Ile Lys Gly  Glu Arg Gly Tyr Thr  Gly Ser Ala 
    1100                 1105                 1110             


Gly Glu  Lys Gly Glu Pro Gly  Pro Pro Gly Ser Glu  Gly Leu Pro 
    1115                 1120                 1125             


Gly Pro  Pro Gly Pro Ala Gly  Pro Arg Gly Glu Arg  Gly Pro Gln 
    1130                 1135                 1140             


Gly Asn  Ser Gly Glu Lys Gly  Asp Gln Gly Phe Gln  Gly Gln Pro 
    1145                 1150                 1155             


Gly Phe  Pro Gly Pro Pro Gly  Pro Pro Gly Phe Pro  Gly Lys Val 
    1160                 1165                 1170             


Gly Ser  Pro Gly Pro Pro Gly  Pro Gln Ala Glu Lys  Gly Ser Glu 
    1175                 1180                 1185             


Gly Ile  Arg Gly Pro Ser Gly  Leu Pro Gly Ser Pro  Gly Pro Pro 
    1190                 1195                 1200             


Gly Pro  Pro Gly Ile Gln Gly  Pro Ala Gly Leu Asp  Gly Leu Asp 
    1205                 1210                 1215             


Gly Lys  Asp Gly Lys Pro Gly  Leu Arg Gly Asp Pro  Gly Pro Ala 
    1220                 1225                 1230             


Gly Pro  Pro Gly Leu Met Gly  Pro Pro Gly Phe Lys  Gly Lys Thr 
    1235                 1240                 1245             


Gly His  Pro Gly Leu Pro Gly  Pro Lys Gly Asp Cys  Gly Lys Pro 
    1250                 1255                 1260             


Gly Pro  Pro Gly Ser Thr Gly  Arg Pro Gly Ala Glu  Gly Glu Pro 
    1265                 1270                 1275             


Gly Ala  Met Gly Pro Gln Gly  Arg Pro Gly Pro Pro  Gly His Val 
    1280                 1285                 1290             


Gly Pro  Pro Gly Pro Pro Gly  Gln Pro Gly Pro Ala  Gly Ile Ser 
    1295                 1300                 1305             


Ala Val  Gly Leu Lys Gly Asp  Arg Gly Ala Thr Gly  Glu Arg Gly 
    1310                 1315                 1320             


Leu Ala  Gly Leu Pro Gly Gln  Pro Gly Pro Pro Gly  His Pro Gly 
    1325                 1330                 1335             


Pro Pro  Gly Glu Pro Gly Thr  Asp Gly Ala Ala Gly  Lys Glu Gly 
    1340                 1345                 1350             


Pro Pro  Gly Lys Gln Gly Phe  Tyr Gly Pro Pro Gly  Pro Lys Gly 
    1355                 1360                 1365             


Asp Pro  Gly Ala Ala Gly Gln  Lys Gly Gln Ala Gly  Glu Lys Gly 
    1370                 1375                 1380             


Arg Ala  Gly Met Pro Gly Gly  Pro Gly Lys Ser Gly  Ser Met Gly 
    1385                 1390                 1395             


Pro Val  Gly Pro Pro Gly Pro  Ala Gly Glu Arg Gly  His Pro Gly 
    1400                 1405                 1410             


Ala Pro  Gly Pro Ser Gly Ser  Pro Gly Leu Pro Gly  Val Pro Gly 
    1415                 1420                 1425             


Ser Met  Gly Asp Met Val Asn  Tyr Asp Glu Ile Lys  Arg Phe Ile 
    1430                 1435                 1440             


Arg Gln  Glu Ile Ile Lys Met  Phe Asp Glu Arg Met  Ala Tyr Tyr 
    1445                 1450                 1455             


Thr Ser  Arg Met Gln Phe Pro  Met Glu Met Ala Ala  Ala Pro Gly 
    1460                 1465                 1470             


Arg Pro  Gly Pro Pro Gly Lys  Asp Gly Ala Pro Gly  Arg Pro Gly 
    1475                 1480                 1485             


Ala Pro  Gly Ser Pro Gly Leu  Pro Gly Gln Ile Gly  Arg Glu Gly 
    1490                 1495                 1500             


Arg Gln  Gly Leu Pro Gly Val  Arg Gly Leu Pro Gly  Thr Lys Gly 
    1505                 1510                 1515             


Glu Lys  Gly Asp Ile Gly Ile  Gly Ile Ala Gly Glu  Asn Gly Leu 
    1520                 1525                 1530             


Pro Gly  Pro Pro Gly Pro Gln  Gly Pro Pro Gly Tyr  Gly Lys Met 
    1535                 1540                 1545             


Gly Ala  Thr Gly Pro Met Gly  Gln Gln Gly Ile Pro  Gly Ile Pro 
    1550                 1555                 1560             


Gly Pro  Pro Gly Pro Met Gly  Gln Pro Gly Lys Ala  Gly His Cys 
    1565                 1570                 1575             


Asn Pro  Ser Asp Cys Phe Gly  Ala Met Pro Met Glu  Gln Gln Tyr 
    1580                 1585                 1590             


Pro Pro  Met Lys Thr Met Lys  Gly Pro Phe Gly 
    1595                 1600                 


<210>  28
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Gly Pro Gly Glu Arg Ala Gly Gly Gly Gly Asp Ala Gly Lys Gly 
1               5                   10                  15      


Asn Ala Ala Gly Gly Gly Gly Gly Gly Arg Ser Ala Thr Thr Ala Gly 
            20                  25                  30          


Ser Arg Ala Val Ser Ala Leu Cys Leu Leu Leu Ser Val Gly Ser Ala 
        35                  40                  45              


Ala Ala Cys Leu Leu Leu Gly Val Gln Ala Ala Ala Leu Gln Gly Arg 
    50                  55                  60                  


Val Ala Ala Leu Glu Glu Glu Arg Glu Leu Leu Arg Arg Ala Gly Pro 
65                  70                  75                  80  


Pro Gly Ala Leu Asp Ala Trp Ala Glu Pro His Leu Glu Arg Leu Leu 
                85                  90                  95      


Arg Glu Lys Leu Asp Gly Leu Ala Lys Ile Arg Thr Ala Arg Glu Ala 
            100                 105                 110         


Pro Ser Glu Cys Val Cys Pro Pro Gly Pro Pro Gly Arg Arg Gly Lys 
        115                 120                 125             


Pro Gly Arg Arg Gly Asp Pro Gly Pro Pro Gly Gln Ser Gly Arg Asp 
    130                 135                 140                 


Gly Tyr Pro Gly Pro Leu Gly Leu Asp Gly Lys Pro Gly Leu Pro Gly 
145                 150                 155                 160 


Pro Lys Gly Glu Lys Gly Ala Pro Gly Asp Phe Gly Pro Arg Gly Asp 
                165                 170                 175     


Gln Gly Gln Asp Gly Ala Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro 
            180                 185                 190         


Gly Ala Arg Gly Pro Pro Gly Asp Thr Gly Lys Asp Gly Pro Arg Gly 
        195                 200                 205             


Ala Gln Gly Pro Ala Gly Pro Lys Gly Glu Pro Gly Gln Asp Gly Glu 
    210                 215                 220                 


Met Gly Pro Lys Gly Pro Pro Gly Pro Lys Gly Glu Pro Gly Val Pro 
225                 230                 235                 240 


Gly Lys Lys Gly Asp Asp Gly Thr Pro Ser Gln Pro Gly Pro Pro Gly 
                245                 250                 255     


Pro Lys Gly Glu Pro Gly Ser Met Gly Pro Arg Gly Glu Asn Gly Val 
            260                 265                 270         


Asp Gly Ala Pro Gly Pro Lys Gly Glu Pro Gly His Arg Gly Thr Asp 
        275                 280                 285             


Gly Ala Ala Gly Pro Arg Gly Ala Pro Gly Leu Lys Gly Glu Gln Gly 
    290                 295                 300                 


Asp Thr Val Val Ile Asp Tyr Asp Gly Arg Ile Leu Asp Ala Leu Lys 
305                 310                 315                 320 


Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly 
                325                 330                 335     


Ala Lys Gly Glu Leu Gly Leu Pro Gly Ala Pro Gly Ile Asp Gly Glu 
            340                 345                 350         


Lys Gly Pro Lys Gly Gln Lys Gly Asp Pro Gly Glu Pro Gly Pro Ala 
        355                 360                 365             


Gly Leu Lys Gly Glu Ala Gly Glu Met Gly Leu Ser Gly Leu Pro Gly 
    370                 375                 380                 


Ala Asp Gly Leu Lys Gly Glu Lys Gly Glu Ser Ala Ser Asp Ser Leu 
385                 390                 395                 400 


Gln Glu Ser Leu Ala Gln Leu Ile Val Glu Pro Gly Pro Pro Gly Pro 
                405                 410                 415     


Pro Gly Pro Pro Gly Pro Met Gly Leu Gln Gly Ile Gln Gly Pro Lys 
            420                 425                 430         


Gly Leu Asp Gly Ala Lys Gly Glu Lys Gly Ala Ser Gly Glu Arg Gly 
        435                 440                 445             


Pro Ser Gly Leu Pro Gly Pro Val Gly Pro Pro Gly Leu Ile Gly Leu 
    450                 455                 460                 


Pro Gly Thr Lys Gly Glu Lys Gly Arg Pro Gly Glu Pro Gly Leu Asp 
465                 470                 475                 480 


Gly Phe Pro Gly Pro Arg Gly Glu Lys Gly Asp Arg Ser Glu Arg Gly 
                485                 490                 495     


Glu Lys Gly Glu Arg Gly Val Pro Gly Arg Lys Gly Val Lys Gly Gln 
            500                 505                 510         


Lys Gly Glu Pro Gly Pro Pro Gly Leu Asp Gln Pro Cys Pro Val Gly 
        515                 520                 525             


Pro Asp Gly Leu Pro Val Pro Gly Cys Trp His Lys 
    530                 535                 540 


<210>  29
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ser His Val Ala Val Glu Asn Ala Leu Gly Leu Asp Gln Gln Phe 
1               5                   10                  15      


Ala Gly Leu Asp Leu Asn Ser Ser Asp Asn Gln Ser Gly Gly Ser Thr 
            20                  25                  30          


Ala Ser Lys Gly Arg Tyr Ile Pro Pro His Leu Arg Asn Arg Glu Ala 
        35                  40                  45              


Thr Lys Gly Phe Tyr Asp Lys Asp Ser Ser Gly Trp Ser Ser Ser Lys 
    50                  55                  60                  


Asp Lys Asp Ala Tyr Ser Ser Phe Gly Ser Arg Ser Asp Ser Arg Gly 
65                  70                  75                  80  


Lys Ser Ser Phe Phe Ser Asp Arg Gly Ser Gly Ser Arg Gly Arg Phe 
                85                  90                  95      


Asp Asp Arg Gly Arg Ser Asp Tyr Asp Gly Ile Gly Ser Arg Gly Asp 
            100                 105                 110         


Arg Ser Gly Phe Gly Lys Phe Glu Arg Gly Gly Asn Ser Arg Trp Cys 
        115                 120                 125             


Asp Lys Ser Asp Glu Asp Asp Trp Ser Lys Pro Leu Pro Pro Ser Glu 
    130                 135                 140                 


Arg Leu Glu Gln Glu Leu Phe Ser Gly Gly Asn Thr Gly Ile Asn Phe 
145                 150                 155                 160 


Glu Lys Tyr Asp Asp Ile Pro Val Glu Ala Thr Gly Asn Asn Cys Pro 
                165                 170                 175     


Pro His Ile Glu Ser Phe Ser Asp Val Glu Met Gly Glu Ile Ile Met 
            180                 185                 190         


Gly Asn Ile Glu Leu Thr Arg Tyr Thr Arg Pro Thr Pro Val Gln Lys 
        195                 200                 205             


His Ala Ile Pro Ile Ile Lys Glu Lys Arg Asp Leu Met Ala Cys Ala 
    210                 215                 220                 


Gln Thr Gly Ser Gly Lys Thr Ala Ala Phe Leu Leu Pro Ile Leu Ser 
225                 230                 235                 240 


Gln Ile Tyr Ser Asp Gly Pro Gly Glu Ala Leu Arg Ala Met Lys Glu 
                245                 250                 255     


Asn Gly Arg Tyr Gly Arg Arg Lys Gln Tyr Pro Ile Ser Leu Val Leu 
            260                 265                 270         


Ala Pro Thr Arg Glu Leu Ala Val Gln Ile Tyr Glu Glu Ala Arg Lys 
        275                 280                 285             


Phe Ser Tyr Arg Ser Arg Val Arg Pro Cys Val Val Tyr Gly Gly Ala 
    290                 295                 300                 


Asp Ile Gly Gln Gln Ile Arg Asp Leu Glu Arg Gly Cys His Leu Leu 
305                 310                 315                 320 


Val Ala Thr Pro Gly Arg Leu Val Asp Met Met Glu Arg Gly Lys Ile 
                325                 330                 335     


Gly Leu Asp Phe Cys Lys Tyr Leu Val Leu Asp Glu Ala Asp Arg Met 
            340                 345                 350         


Leu Asp Met Gly Phe Glu Pro Gln Ile Arg Arg Ile Val Glu Gln Asp 
        355                 360                 365             


Thr Met Pro Pro Lys Gly Val Arg His Thr Met Met Phe Ser Ala Thr 
    370                 375                 380                 


Phe Pro Lys Glu Ile Gln Met Leu Ala Arg Asp Phe Leu Asp Glu Tyr 
385                 390                 395                 400 


Ile Phe Leu Ala Val Gly Arg Val Gly Ser Thr Ser Glu Asn Ile Thr 
                405                 410                 415     


Gln Lys Val Val Trp Val Glu Glu Ser Asp Lys Arg Ser Phe Leu Leu 
            420                 425                 430         


Asp Leu Leu Asn Ala Thr Gly Lys Asp Ser Leu Thr Leu Val Phe Val 
        435                 440                 445             


Glu Thr Lys Lys Gly Ala Asp Ser Leu Glu Asp Phe Leu Tyr His Glu 
    450                 455                 460                 


Gly Tyr Ala Cys Thr Ser Ile His Gly Asp Arg Ser Gln Arg Asp Arg 
465                 470                 475                 480 


Glu Glu Ala Leu His Gln Phe Arg Ser Gly Lys Ser Pro Ile Leu Val 
                485                 490                 495     


Ala Thr Ala Val Ala Ala Arg Gly Leu Asp Ile Ser Asn Val Lys His 
            500                 505                 510         


Val Ile Asn Phe Asp Leu Pro Ser Asp Ile Glu Glu Tyr Val His Arg 
        515                 520                 525             


Ile Gly Arg Thr Gly Arg Val Gly Asn Leu Gly Leu Ala Thr Ser Phe 
    530                 535                 540                 


Phe Asn Glu Arg Asn Ile Asn Ile Thr Lys Asp Leu Leu Asp Leu Leu 
545                 550                 555                 560 


Val Glu Ala Lys Gln Glu Val Pro Ser Trp Leu Glu Asn Met Ala Tyr 
                565                 570                 575     


Glu His His Tyr Lys Gly Ser Ser Arg Gly Arg Ser Lys Ser Ser Arg 
            580                 585                 590         


Phe Ser Gly Gly Phe Gly Ala Arg Asp Tyr Arg Gln Ser Ser Gly Ala 
        595                 600                 605             


Ser Ser Ser Ser Phe Ser Ser Ser Arg Ala Ser Ser Ser Arg Ser Gly 
    610                 615                 620                 


Gly Gly Gly His Gly Ser Ser Arg Gly Phe Gly Gly Gly Gly Tyr Gly 
625                 630                 635                 640 


Gly Phe Tyr Asn Ser Asp Gly Tyr Gly Gly Asn Tyr Asn Ser Gln Gly 
                645                 650                 655     


Val Asp Trp Trp Gly Asn 
            660         


<210>  30
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Ser Ala Thr Ala Ala Ala Ala Arg Arg Gly Leu Gly Arg Ala 
1               5                   10                  15      


Leu Pro Leu Phe Trp Arg Gly Tyr Gln Thr Glu Arg Gly Val Tyr Gly 
            20                  25                  30          


Tyr Arg Pro Arg Lys Pro Glu Ser Arg Glu Pro Gln Gly Ala Leu Glu 
        35                  40                  45              


Arg Pro Pro Val Asp His Gly Leu Ala Arg Leu Val Thr Val Tyr Cys 
    50                  55                  60                  


Glu His Gly His Lys Ala Ala Lys Ile Asn Pro Leu Phe Thr Gly Gln 
65                  70                  75                  80  


Ala Leu Leu Glu Asn Val Pro Glu Ile Gln Ala Leu Val Gln Thr Leu 
                85                  90                  95      


Gln Gly Pro Phe His Thr Ala Gly Leu Leu Asn Met Gly Lys Glu Glu 
            100                 105                 110         


Ala Ser Leu Glu Glu Val Leu Val Tyr Leu Asn Gln Ile Tyr Cys Gly 
        115                 120                 125             


Gln Ile Ser Ile Glu Thr Ser Gln Leu Gln Ser Gln Asp Glu Lys Asp 
    130                 135                 140                 


Trp Phe Ala Lys Arg Phe Glu Glu Leu Gln Lys Glu Thr Phe Thr Thr 
145                 150                 155                 160 


Glu Glu Arg Lys His Leu Ser Lys Leu Met Leu Glu Ser Gln Glu Phe 
                165                 170                 175     


Asp His Phe Leu Ala Thr Lys Phe Ser Thr Val Lys Arg Tyr Gly Gly 
            180                 185                 190         


Glu Gly Ala Glu Ser Met Met Gly Phe Phe His Glu Leu Leu Lys Met 
        195                 200                 205             


Ser Ala Tyr Ser Gly Ile Thr Asp Val Ile Ile Gly Met Pro His Arg 
    210                 215                 220                 


Gly Arg Leu Asn Leu Leu Thr Gly Leu Leu Gln Phe Pro Pro Glu Leu 
225                 230                 235                 240 


Met Phe Arg Lys Met Arg Gly Leu Ser Glu Phe Pro Glu Asn Phe Ser 
                245                 250                 255     


Ala Thr Gly Asp Val Leu Ser His Leu Thr Ser Ser Val Asp Leu Tyr 
            260                 265                 270         


Phe Gly Ala His His Pro Leu His Val Thr Met Leu Pro Asn Pro Ser 
        275                 280                 285             


His Leu Glu Ala Val Asn Pro Val Ala Val Gly Lys Thr Arg Gly Arg 
    290                 295                 300                 


Gln Gln Ser Arg Gln Asp Gly Asp Tyr Ser Pro Asp Asn Ser Ala Gln 
305                 310                 315                 320 


Pro Gly Asp Arg Val Ile Cys Leu Gln Val His Gly Asp Ala Ser Phe 
                325                 330                 335     


Cys Gly Gln Gly Ile Val Pro Glu Thr Phe Thr Leu Ser Asn Leu Pro 
            340                 345                 350         


His Phe Arg Ile Gly Gly Ser Val His Leu Ile Val Asn Asn Gln Leu 
        355                 360                 365             


Gly Tyr Thr Thr Pro Ala Glu Arg Gly Arg Ser Ser Leu Tyr Cys Ser 
    370                 375                 380                 


Asp Ile Gly Lys Leu Val Gly Cys Ala Ile Ile His Val Asn Gly Asp 
385                 390                 395                 400 


Ser Pro Glu Glu Val Val Arg Ala Thr Arg Leu Ala Phe Glu Tyr Gln 
                405                 410                 415     


Arg Gln Phe Arg Lys Asp Val Ile Ile Asp Leu Leu Cys Tyr Arg Gln 
            420                 425                 430         


Trp Gly His Asn Glu Leu Asp Glu Pro Phe Tyr Thr Asn Pro Ile Met 
        435                 440                 445             


Tyr Lys Ile Ile Arg Ala Arg Lys Ser Ile Pro Asp Thr Tyr Ala Glu 
    450                 455                 460                 


His Leu Ile Ala Gly Gly Leu Met Thr Gln Glu Glu Val Ser Glu Ile 
465                 470                 475                 480 


Lys Ser Ser Tyr Tyr Ala Lys Leu Asn Asp His Leu Asn Asn Met Ala 
                485                 490                 495     


His Tyr Arg Pro Pro Ala Leu Asn Leu Gln Ala His Trp Gln Gly Leu 
            500                 505                 510         


Ala Gln Pro Glu Ala Gln Ile Thr Thr Trp Ser Thr Gly Val Pro Leu 
        515                 520                 525             


Asp Leu Leu Arg Phe Val Gly Met Lys Ser Val Glu Val Pro Arg Glu 
    530                 535                 540                 


Leu Gln Met His Ser His Leu Leu Lys Thr His Val Gln Ser Arg Met 
545                 550                 555                 560 


Glu Lys Met Met Asp Gly Ile Lys Leu Asp Trp Ala Thr Ala Glu Ala 
                565                 570                 575     


Leu Ala Leu Gly Ser Leu Leu Ala Gln Gly Phe Asn Val Arg Leu Ser 
            580                 585                 590         


Gly Gln Asp Val Gly Arg Gly Thr Phe Ser Gln Arg His Ala Ile Val 
        595                 600                 605             


Val Cys Gln Glu Thr Asp Asp Thr Tyr Ile Pro Leu Asn His Met Asp 
    610                 615                 620                 


Pro Asn Gln Lys Gly Phe Leu Glu Val Ser Asn Ser Pro Leu Ser Glu 
625                 630                 635                 640 


Glu Ala Val Leu Gly Phe Glu Tyr Gly Met Ser Ile Glu Ser Pro Lys 
                645                 650                 655     


Leu Leu Pro Leu Trp Glu Ala Gln Phe Gly Asp Phe Phe Asn Gly Ala 
            660                 665                 670         


Gln Ile Ile Phe Asp Thr Phe Ile Ser Gly Gly Glu Ala Lys Trp Leu 
        675                 680                 685             


Leu Gln Ser Gly Ile Val Ile Leu Leu Pro His Gly Tyr Asp Gly Ala 
    690                 695                 700                 


Gly Pro Asp His Ser Ser Cys Arg Ile Glu Arg Phe Leu Gln Met Cys 
705                 710                 715                 720 


Asp Ser Ala Glu Glu Gly Val Asp Gly Asp Thr Val Asn Met Phe Val 
                725                 730                 735     


Val His Pro Thr Thr Pro Ala Gln Tyr Phe His Leu Leu Arg Arg Gln 
            740                 745                 750         


Met Val Arg Asn Phe Arg Lys Pro Leu Ile Val Ala Ser Pro Lys Met 
        755                 760                 765             


Leu Leu Arg Leu Pro Ala Ala Val Ser Thr Leu Gln Glu Met Ala Pro 
    770                 775                 780                 


Gly Thr Thr Phe Asn Pro Val Ile Gly Asp Ser Ser Val Asp Pro Lys 
785                 790                 795                 800 


Lys Val Lys Thr Leu Val Phe Cys Ser Gly Lys His Phe Tyr Ser Leu 
                805                 810                 815     


Val Lys Gln Arg Glu Ser Leu Gly Ala Lys Lys His Asp Phe Ala Ile 
            820                 825                 830         


Ile Arg Val Glu Glu Leu Cys Pro Phe Pro Leu Asp Ser Leu Gln Gln 
        835                 840                 845             


Glu Met Ser Lys Tyr Lys His Val Lys Asp His Ile Trp Ser Gln Glu 
    850                 855                 860                 


Glu Pro Gln Asn Met Gly Pro Trp Ser Phe Val Ser Pro Arg Phe Glu 
865                 870                 875                 880 


Lys Gln Leu Ala Cys Lys Leu Arg Leu Val Gly Arg Pro Pro Leu Pro 
                885                 890                 895     


Val Pro Ala Val Gly Ile Gly Thr Val His Leu His Gln His Glu Asp 
            900                 905                 910         


Ile Leu Ala Lys Thr Phe Ala 
        915                 


<210>  31
<211>  2871
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ser Cys Asn Gly Gly Ser His Pro Arg Ile Asn Thr Leu Gly Arg 
1               5                   10                  15      


Met Ile Arg Ala Glu Ser Gly Pro Asp Leu Arg Tyr Glu Val Thr Ser 
            20                  25                  30          


Gly Gly Gly Gly Thr Ser Arg Met Tyr Tyr Ser Arg Arg Gly Val Ile 
        35                  40                  45              


Thr Asp Gln Asn Ser Asp Gly Tyr Cys Gln Thr Gly Thr Met Ser Arg 
    50                  55                  60                  


His Gln Asn Gln Asn Thr Ile Gln Glu Leu Leu Gln Asn Cys Ser Asp 
65                  70                  75                  80  


Cys Leu Met Arg Ala Glu Leu Ile Val Gln Pro Glu Leu Lys Tyr Gly 
                85                  90                  95      


Asp Gly Ile Gln Leu Thr Arg Ser Arg Glu Leu Asp Glu Cys Phe Ala 
            100                 105                 110         


Gln Ala Asn Asp Gln Met Glu Ile Leu Asp Ser Leu Ile Arg Glu Met 
        115                 120                 125             


Arg Gln Met Gly Gln Pro Cys Asp Ala Tyr Gln Lys Arg Leu Leu Gln 
    130                 135                 140                 


Leu Gln Glu Gln Met Arg Ala Leu Tyr Lys Ala Ile Ser Val Pro Arg 
145                 150                 155                 160 


Val Arg Arg Ala Ser Ser Lys Gly Gly Gly Gly Tyr Thr Cys Gln Ser 
                165                 170                 175     


Gly Ser Gly Trp Asp Glu Phe Thr Lys His Val Thr Ser Glu Cys Leu 
            180                 185                 190         


Gly Trp Met Arg Gln Gln Arg Ala Glu Met Asp Met Val Ala Trp Gly 
        195                 200                 205             


Val Asp Leu Ala Ser Val Glu Gln His Ile Asn Ser His Arg Gly Ile 
    210                 215                 220                 


His Asn Ser Ile Gly Asp Tyr Arg Trp Gln Leu Asp Lys Ile Lys Ala 
225                 230                 235                 240 


Asp Leu Arg Glu Lys Ser Ala Ile Tyr Gln Leu Glu Glu Glu Tyr Glu 
                245                 250                 255     


Asn Leu Leu Lys Ala Ser Phe Glu Arg Met Asp His Leu Arg Gln Leu 
            260                 265                 270         


Gln Asn Ile Ile Gln Ala Thr Ser Arg Glu Ile Met Trp Ile Asn Asp 
        275                 280                 285             


Cys Glu Glu Glu Glu Leu Leu Tyr Asp Trp Ser Asp Lys Asn Thr Asn 
    290                 295                 300                 


Ile Ala Gln Lys Gln Glu Ala Phe Ser Ile Arg Met Ser Gln Leu Glu 
305                 310                 315                 320 


Val Lys Glu Lys Glu Leu Asn Lys Leu Lys Gln Glu Ser Asp Gln Leu 
                325                 330                 335     


Val Leu Asn Gln His Pro Ala Ser Asp Lys Ile Glu Ala Tyr Met Asp 
            340                 345                 350         


Thr Leu Gln Thr Gln Trp Ser Trp Ile Leu Gln Ile Thr Lys Cys Ile 
        355                 360                 365             


Asp Val His Leu Lys Glu Asn Ala Ala Tyr Phe Gln Phe Phe Glu Glu 
    370                 375                 380                 


Ala Gln Ser Thr Glu Ala Tyr Leu Lys Gly Leu Gln Asp Ser Ile Arg 
385                 390                 395                 400 


Lys Lys Tyr Pro Cys Asp Lys Asn Met Pro Leu Gln His Leu Leu Glu 
                405                 410                 415     


Gln Ile Lys Glu Leu Glu Lys Glu Arg Glu Lys Ile Leu Glu Tyr Lys 
            420                 425                 430         


Arg Gln Val Gln Asn Leu Val Asn Lys Ser Lys Lys Ile Val Gln Leu 
        435                 440                 445             


Lys Pro Arg Asn Pro Asp Tyr Arg Ser Asn Lys Pro Ile Ile Leu Arg 
    450                 455                 460                 


Ala Leu Cys Asp Tyr Lys Gln Asp Gln Lys Ile Val His Lys Gly Asp 
465                 470                 475                 480 


Glu Cys Ile Leu Lys Asp Asn Asn Glu Arg Ser Lys Trp Tyr Val Thr 
                485                 490                 495     


Gly Pro Gly Gly Val Asp Met Leu Val Pro Ser Val Gly Leu Ile Ile 
            500                 505                 510         


Pro Pro Pro Asn Pro Leu Ala Val Asp Leu Ser Cys Lys Ile Glu Gln 
        515                 520                 525             


Tyr Tyr Glu Ala Ile Leu Ala Leu Trp Asn Gln Leu Tyr Ile Asn Met 
    530                 535                 540                 


Lys Ser Leu Val Ser Trp His Tyr Cys Met Ile Asp Ile Glu Lys Ile 
545                 550                 555                 560 


Arg Ala Met Thr Ile Ala Lys Leu Lys Thr Met Arg Gln Glu Asp Tyr 
                565                 570                 575     


Met Lys Thr Ile Ala Asp Leu Glu Leu His Tyr Gln Glu Phe Ile Arg 
            580                 585                 590         


Asn Ser Gln Gly Ser Glu Met Phe Gly Asp Asp Asp Lys Arg Lys Ile 
        595                 600                 605             


Gln Ser Gln Phe Thr Asp Ala Gln Lys His Tyr Gln Thr Leu Val Ile 
    610                 615                 620                 


Gln Leu Pro Gly Tyr Pro Gln His Gln Thr Val Thr Thr Thr Glu Ile 
625                 630                 635                 640 


Thr His His Gly Thr Cys Gln Asp Val Asn His Asn Lys Val Ile Glu 
                645                 650                 655     


Thr Asn Arg Glu Asn Asp Lys Gln Glu Thr Trp Met Leu Met Glu Leu 
            660                 665                 670         


Gln Lys Ile Arg Arg Gln Ile Glu His Cys Glu Gly Arg Met Thr Leu 
        675                 680                 685             


Lys Asn Leu Pro Leu Ala Asp Gln Gly Ser Ser His His Ile Thr Val 
    690                 695                 700                 


Lys Ile Asn Glu Leu Lys Ser Val Gln Asn Asp Ser Gln Ala Ile Ala 
705                 710                 715                 720 


Glu Val Leu Asn Gln Leu Lys Asp Met Leu Ala Asn Phe Arg Gly Ser 
                725                 730                 735     


Glu Lys Tyr Cys Tyr Leu Gln Asn Glu Val Phe Gly Leu Phe Gln Lys 
            740                 745                 750         


Leu Glu Asn Ile Asn Gly Val Thr Asp Gly Tyr Leu Asn Ser Leu Cys 
        755                 760                 765             


Thr Val Arg Ala Leu Leu Gln Ala Ile Leu Gln Thr Glu Asp Met Leu 
    770                 775                 780                 


Lys Val Tyr Glu Ala Arg Leu Thr Glu Glu Glu Thr Val Cys Leu Asp 
785                 790                 795                 800 


Leu Asp Lys Val Glu Ala Tyr Arg Cys Gly Leu Lys Lys Ile Lys Asn 
                805                 810                 815     


Asp Leu Asn Leu Lys Lys Ser Leu Leu Ala Thr Met Lys Thr Glu Leu 
            820                 825                 830         


Gln Lys Ala Gln Gln Ile His Ser Gln Thr Ser Gln Gln Tyr Pro Leu 
        835                 840                 845             


Tyr Asp Leu Asp Leu Gly Lys Phe Gly Glu Lys Val Thr Gln Leu Thr 
    850                 855                 860                 


Asp Arg Trp Gln Arg Ile Asp Lys Gln Ile Asp Phe Arg Leu Trp Asp 
865                 870                 875                 880 


Leu Glu Lys Gln Ile Lys Gln Leu Arg Asn Tyr Arg Asp Asn Tyr Gln 
                885                 890                 895     


Ala Phe Cys Lys Trp Leu Tyr Asp Ala Lys Arg Arg Gln Asp Ser Leu 
            900                 905                 910         


Glu Ser Met Lys Phe Gly Asp Ser Asn Thr Val Met Arg Phe Leu Asn 
        915                 920                 925             


Glu Gln Lys Asn Leu His Ser Glu Ile Ser Gly Lys Arg Asp Lys Ser 
    930                 935                 940                 


Glu Glu Val Gln Lys Ile Ala Glu Leu Cys Ala Asn Ser Ile Lys Asp 
945                 950                 955                 960 


Tyr Glu Leu Gln Leu Ala Ser Tyr Thr Ser Gly Leu Glu Thr Leu Leu 
                965                 970                 975     


Asn Ile Pro Ile Lys Arg Thr Met Ile Gln Ser Pro Ser Gly Val Ile 
            980                 985                 990         


Leu Gln Glu Ala Ala Asp Val His  Ala Arg Tyr Ile Glu  Leu Leu Thr 
        995                 1000                 1005             


Arg Ser  Gly Asp Tyr Tyr Arg  Phe Leu Ser Glu Met  Leu Lys Ser 
    1010                 1015                 1020             


Leu Glu  Asp Leu Lys Leu Lys  Asn Thr Lys Ile Glu  Val Leu Glu 
    1025                 1030                 1035             


Glu Glu  Leu Arg Leu Ala Arg  Asp Ala Asn Ser Glu  Asn Cys Asn 
    1040                 1045                 1050             


Lys Asn  Lys Phe Leu Asp Gln  Asn Leu Gln Lys Tyr  Gln Ala Glu 
    1055                 1060                 1065             


Cys Ser  Gln Phe Lys Ala Lys  Leu Ala Ser Leu Glu  Glu Leu Lys 
    1070                 1075                 1080             


Arg Gln  Ala Glu Leu Asp Gly  Lys Ser Ala Lys Gln  Asn Leu Asp 
    1085                 1090                 1095             


Lys Cys  Tyr Gly Gln Ile Lys  Glu Leu Asn Glu Lys  Ile Thr Arg 
    1100                 1105                 1110             


Leu Thr  Tyr Glu Ile Glu Asp  Glu Lys Arg Arg Arg  Lys Ser Val 
    1115                 1120                 1125             


Glu Asp  Arg Phe Asp Gln Gln  Lys Asn Asp Tyr Asp  Gln Leu Gln 
    1130                 1135                 1140             


Lys Ala  Arg Gln Cys Glu Lys  Glu Asn Leu Gly Trp  Gln Lys Leu 
    1145                 1150                 1155             


Glu Ser  Glu Lys Ala Ile Lys  Glu Lys Glu Tyr Glu  Ile Glu Arg 
    1160                 1165                 1170             


Leu Arg  Val Leu Leu Gln Glu  Glu Gly Thr Arg Lys  Arg Glu Tyr 
    1175                 1180                 1185             


Glu Asn  Glu Leu Ala Lys Val  Arg Asn His Tyr Asn  Glu Glu Met 
    1190                 1195                 1200             


Ser Asn  Leu Arg Asn Lys Tyr  Glu Thr Glu Ile Asn  Ile Thr Lys 
    1205                 1210                 1215             


Thr Thr  Ile Lys Glu Ile Ser  Met Gln Lys Glu Asp  Asp Ser Lys 
    1220                 1225                 1230             


Asn Leu  Arg Asn Gln Leu Asp  Arg Leu Ser Arg Glu  Asn Arg Asp 
    1235                 1240                 1245             


Leu Lys  Asp Glu Ile Val Arg  Leu Asn Asp Ser Ile  Leu Gln Ala 
    1250                 1255                 1260             


Thr Glu  Gln Arg Arg Arg Ala  Glu Glu Asn Ala Leu  Gln Gln Lys 
    1265                 1270                 1275             


Ala Cys  Gly Ser Glu Ile Met  Gln Lys Lys Gln His  Leu Glu Ile 
    1280                 1285                 1290             


Glu Leu  Lys Gln Val Met Gln  Gln Arg Ser Glu Asp  Asn Ala Arg 
    1295                 1300                 1305             


His Lys  Gln Ser Leu Glu Glu  Ala Ala Lys Thr Ile  Gln Asp Lys 
    1310                 1315                 1320             


Asn Lys  Glu Ile Glu Arg Leu  Lys Ala Glu Phe Gln  Glu Glu Ala 
    1325                 1330                 1335             


Lys Arg  Arg Trp Glu Tyr Glu  Asn Glu Leu Ser Lys  Val Arg Asn 
    1340                 1345                 1350             


Asn Tyr  Asp Glu Glu Ile Ile  Ser Leu Lys Asn Gln  Phe Glu Thr 
    1355                 1360                 1365             


Glu Ile  Asn Ile Thr Lys Thr  Thr Ile His Gln Leu  Thr Met Gln 
    1370                 1375                 1380             


Lys Glu  Glu Asp Thr Ser Gly  Tyr Arg Ala Gln Ile  Asp Asn Leu 
    1385                 1390                 1395             


Thr Arg  Glu Asn Arg Ser Leu  Ser Glu Glu Ile Lys  Arg Leu Lys 
    1400                 1405                 1410             


Asn Thr  Leu Thr Gln Thr Thr  Glu Asn Leu Arg Arg  Val Glu Glu 
    1415                 1420                 1425             


Asp Ile  Gln Gln Gln Lys Ala  Thr Gly Ser Glu Val  Ser Gln Arg 
    1430                 1435                 1440             


Lys Gln  Gln Leu Glu Val Glu  Leu Arg Gln Val Thr  Gln Met Arg 
    1445                 1450                 1455             


Thr Glu  Glu Ser Val Arg Tyr  Lys Gln Ser Leu Asp  Asp Ala Ala 
    1460                 1465                 1470             


Lys Thr  Ile Gln Asp Lys Asn  Lys Glu Ile Glu Arg  Leu Lys Gln 
    1475                 1480                 1485             


Leu Ile  Asp Lys Glu Thr Asn  Asp Arg Lys Cys Leu  Glu Asp Glu 
    1490                 1495                 1500             


Asn Ala  Arg Leu Gln Arg Val  Gln Tyr Asp Leu Gln  Lys Ala Asn 
    1505                 1510                 1515             


Ser Ser  Ala Thr Glu Thr Ile  Asn Lys Leu Lys Val  Gln Glu Gln 
    1520                 1525                 1530             


Glu Leu  Thr Arg Leu Arg Ile  Asp Tyr Glu Arg Val  Ser Gln Glu 
    1535                 1540                 1545             


Arg Thr  Val Lys Asp Gln Asp  Ile Thr Arg Phe Gln  Asn Ser Leu 
    1550                 1555                 1560             


Lys Glu  Leu Gln Leu Gln Lys  Gln Lys Val Glu Glu  Glu Leu Asn 
    1565                 1570                 1575             


Arg Leu  Lys Arg Thr Ala Ser  Glu Asp Ser Cys Lys  Arg Lys Lys 
    1580                 1585                 1590             


Leu Glu  Glu Glu Leu Glu Gly  Met Arg Arg Ser Leu  Lys Glu Gln 
    1595                 1600                 1605             


Ala Ile  Lys Ile Thr Asn Leu  Thr Gln Gln Leu Glu  Gln Ala Ser 
    1610                 1615                 1620             


Ile Val  Lys Lys Arg Ser Glu  Asp Asp Leu Arg Gln  Gln Arg Asp 
    1625                 1630                 1635             


Val Leu  Asp Gly His Leu Arg  Glu Lys Gln Arg Thr  Gln Glu Glu 
    1640                 1645                 1650             


Leu Arg  Arg Leu Ser Ser Glu  Val Glu Ala Leu Arg  Arg Gln Leu 
    1655                 1660                 1665             


Leu Gln  Glu Gln Glu Ser Val  Lys Gln Ala His Leu  Arg Asn Glu 
    1670                 1675                 1680             


His Phe  Gln Lys Ala Ile Glu  Asp Lys Ser Arg Ser  Leu Asn Glu 
    1685                 1690                 1695             


Ser Lys  Ile Glu Ile Glu Arg  Leu Gln Ser Leu Thr  Glu Asn Leu 
    1700                 1705                 1710             


Thr Lys  Glu His Leu Met Leu  Glu Glu Glu Leu Arg  Asn Leu Arg 
    1715                 1720                 1725             


Leu Glu  Tyr Asp Asp Leu Arg  Arg Gly Arg Ser Glu  Ala Asp Ser 
    1730                 1735                 1740             


Asp Lys  Asn Ala Thr Ile Leu  Glu Leu Arg Ser Gln  Leu Gln Ile 
    1745                 1750                 1755             


Ser Asn  Asn Arg Thr Leu Glu  Leu Gln Gly Leu Ile  Asn Asp Leu 
    1760                 1765                 1770             


Gln Arg  Glu Arg Glu Asn Leu  Arg Gln Glu Ile Glu  Lys Phe Gln 
    1775                 1780                 1785             


Lys Gln  Ala Leu Glu Ala Ser  Asn Arg Ile Gln Glu  Ser Lys Asn 
    1790                 1795                 1800             


Gln Cys  Thr Gln Val Val Gln  Glu Arg Glu Ser Leu  Leu Val Lys 
    1805                 1810                 1815             


Ile Lys  Val Leu Glu Gln Asp  Lys Ala Arg Leu Gln  Arg Leu Glu 
    1820                 1825                 1830             


Asp Glu  Leu Asn Arg Ala Lys  Ser Thr Leu Glu Ala  Glu Thr Arg 
    1835                 1840                 1845             


Val Lys  Gln Arg Leu Glu Cys  Glu Lys Gln Gln Ile  Gln Asn Asp 
    1850                 1855                 1860             


Leu Asn  Gln Trp Lys Thr Gln  Tyr Ser Arg Lys Glu  Glu Ala Ile 
    1865                 1870                 1875             


Arg Lys  Ile Glu Ser Glu Arg  Glu Lys Ser Glu Arg  Glu Lys Asn 
    1880                 1885                 1890             


Ser Leu  Arg Ser Glu Ile Glu  Arg Leu Gln Ala Glu  Ile Lys Arg 
    1895                 1900                 1905             


Ile Glu  Glu Arg Cys Arg Arg  Lys Leu Glu Asp Ser  Thr Arg Glu 
    1910                 1915                 1920             


Thr Gln  Ser Gln Leu Glu Thr  Glu Arg Ser Arg Tyr  Gln Arg Glu 
    1925                 1930                 1935             


Ile Asp  Lys Leu Arg Gln Arg  Pro Tyr Gly Ser His  Arg Glu Thr 
    1940                 1945                 1950             


Gln Thr  Glu Cys Glu Trp Thr  Val Asp Thr Ser Lys  Leu Val Phe 
    1955                 1960                 1965             


Asp Gly  Leu Arg Lys Lys Val  Thr Ala Met Gln Leu  Tyr Glu Cys 
    1970                 1975                 1980             


Gln Leu  Ile Asp Lys Thr Thr  Leu Asp Lys Leu Leu  Lys Gly Lys 
    1985                 1990                 1995             


Lys Ser  Val Glu Glu Val Ala  Ser Glu Ile Gln Pro  Phe Leu Arg 
    2000                 2005                 2010             


Gly Ala  Gly Ser Ile Ala Gly  Ala Ser Ala Ser Pro  Lys Glu Lys 
    2015                 2020                 2025             


Tyr Ser  Leu Val Glu Ala Lys  Arg Lys Lys Leu Ile  Ser Pro Glu 
    2030                 2035                 2040             


Ser Thr  Val Met Leu Leu Glu  Ala Gln Ala Ala Thr  Gly Gly Ile 
    2045                 2050                 2055             


Ile Asp  Pro His Arg Asn Glu  Lys Leu Thr Val Asp  Ser Ala Ile 
    2060                 2065                 2070             


Ala Arg  Asp Leu Ile Asp Phe  Asp Asp Arg Gln Gln  Ile Tyr Ala 
    2075                 2080                 2085             


Ala Glu  Lys Ala Ile Thr Gly  Phe Asp Asp Pro Phe  Ser Gly Lys 
    2090                 2095                 2100             


Thr Val  Ser Val Ser Glu Ala  Ile Lys Lys Asn Leu  Ile Asp Arg 
    2105                 2110                 2115             


Glu Thr  Gly Met Arg Leu Leu  Glu Ala Gln Ile Ala  Ser Gly Gly 
    2120                 2125                 2130             


Val Val  Asp Pro Val Asn Ser  Val Phe Leu Pro Lys  Asp Val Ala 
    2135                 2140                 2145             


Leu Ala  Arg Gly Leu Ile Asp  Arg Asp Leu Tyr Arg  Ser Leu Asn 
    2150                 2155                 2160             


Asp Pro  Arg Asp Ser Gln Lys  Asn Phe Val Asp Pro  Val Thr Lys 
    2165                 2170                 2175             


Lys Lys  Val Ser Tyr Val Gln  Leu Lys Glu Arg Cys  Arg Ile Glu 
    2180                 2185                 2190             


Pro His  Thr Gly Leu Leu Leu  Leu Ser Val Gln Lys  Arg Ser Met 
    2195                 2200                 2205             


Ser Phe  Gln Gly Ile Arg Gln  Pro Val Thr Val Thr  Glu Leu Val 
    2210                 2215                 2220             


Asp Ser  Gly Ile Leu Arg Pro  Ser Thr Val Asn Glu  Leu Glu Ser 
    2225                 2230                 2235             


Gly Gln  Ile Ser Tyr Asp Glu  Val Gly Glu Arg Ile  Lys Asp Phe 
    2240                 2245                 2250             


Leu Gln  Gly Ser Ser Cys Ile  Ala Gly Ile Tyr Asn  Glu Thr Thr 
    2255                 2260                 2265             


Lys Gln  Lys Leu Gly Ile Tyr  Glu Ala Met Lys Ile  Gly Leu Val 
    2270                 2275                 2280             


Arg Pro  Gly Thr Ala Leu Glu  Leu Leu Glu Ala Gln  Ala Ala Thr 
    2285                 2290                 2295             


Gly Phe  Ile Val Asp Pro Val  Ser Asn Leu Arg Leu  Pro Val Glu 
    2300                 2305                 2310             


Glu Ala  Tyr Lys Arg Gly Leu  Val Gly Ile Glu Phe  Lys Glu Lys 
    2315                 2320                 2325             


Leu Leu  Ser Ala Glu Arg Ala  Val Thr Gly Tyr Asn  Asp Pro Glu 
    2330                 2335                 2340             


Thr Gly  Asn Ile Ile Ser Leu  Phe Gln Ala Met Asn  Lys Glu Leu 
    2345                 2350                 2355             


Ile Glu  Lys Gly His Gly Ile  Arg Leu Leu Glu Ala  Gln Ile Ala 
    2360                 2365                 2370             


Thr Gly  Gly Ile Ile Asp Pro  Lys Glu Ser His Arg  Leu Pro Val 
    2375                 2380                 2385             


Asp Ile  Ala Tyr Lys Arg Gly  Tyr Phe Asn Glu Glu  Leu Ser Glu 
    2390                 2395                 2400             


Ile Leu  Ser Asp Pro Ser Asp  Asp Thr Lys Gly Phe  Phe Asp Pro 
    2405                 2410                 2415             


Asn Thr  Glu Glu Asn Leu Thr  Tyr Leu Gln Leu Lys  Glu Arg Cys 
    2420                 2425                 2430             


Ile Lys  Asp Glu Glu Thr Gly  Leu Cys Leu Leu Pro  Leu Lys Glu 
    2435                 2440                 2445             


Lys Lys  Lys Gln Val Gln Thr  Ser Gln Lys Asn Thr  Leu Arg Lys 
    2450                 2455                 2460             


Arg Arg  Val Val Ile Val Asp  Pro Glu Thr Asn Lys  Glu Met Ser 
    2465                 2470                 2475             


Val Gln  Glu Ala Tyr Lys Lys  Gly Leu Ile Asp Tyr  Glu Thr Phe 
    2480                 2485                 2490             


Lys Glu  Leu Cys Glu Gln Glu  Cys Glu Trp Glu Glu  Ile Thr Ile 
    2495                 2500                 2505             


Thr Gly  Ser Asp Gly Ser Thr  Arg Val Val Leu Val  Asp Arg Lys 
    2510                 2515                 2520             


Thr Gly  Ser Gln Tyr Asp Ile  Gln Asp Ala Ile Asp  Lys Gly Leu 
    2525                 2530                 2535             


Val Asp  Arg Lys Phe Phe Asp  Gln Tyr Arg Ser Gly  Ser Leu Ser 
    2540                 2545                 2550             


Leu Thr  Gln Phe Ala Asp Met  Ile Ser Leu Lys Asn  Gly Val Gly 
    2555                 2560                 2565             


Thr Ser  Ser Ser Met Gly Ser  Gly Val Ser Asp Asp  Val Phe Ser 
    2570                 2575                 2580             


Ser Ser  Arg His Glu Ser Val  Ser Lys Ile Ser Thr  Ile Ser Ser 
    2585                 2590                 2595             


Val Arg  Asn Leu Thr Ile Arg  Ser Ser Ser Phe Ser  Asp Thr Leu 
    2600                 2605                 2610             


Glu Glu  Ser Ser Pro Ile Ala  Ala Ile Phe Asp Thr  Glu Asn Leu 
    2615                 2620                 2625             


Glu Lys  Ile Ser Ile Thr Glu  Gly Ile Glu Arg Gly  Ile Val Asp 
    2630                 2635                 2640             


Ser Ile  Thr Gly Gln Arg Leu  Leu Glu Ala Gln Ala  Cys Thr Gly 
    2645                 2650                 2655             


Gly Ile  Ile His Pro Thr Thr  Gly Gln Lys Leu Ser  Leu Gln Asp 
    2660                 2665                 2670             


Ala Val  Ser Gln Gly Val Ile  Asp Gln Asp Met Ala  Thr Arg Leu 
    2675                 2680                 2685             


Lys Pro  Ala Gln Lys Ala Phe  Ile Gly Phe Glu Gly  Val Lys Gly 
    2690                 2695                 2700             


Lys Lys  Lys Met Ser Ala Ala  Glu Ala Val Lys Glu  Lys Trp Leu 
    2705                 2710                 2715             


Pro Tyr  Glu Ala Gly Gln Arg  Phe Leu Glu Phe Gln  Tyr Leu Thr 
    2720                 2725                 2730             


Gly Gly  Leu Val Asp Pro Glu  Val His Gly Arg Ile  Ser Thr Glu 
    2735                 2740                 2745             


Glu Ala  Ile Arg Lys Gly Phe  Ile Asp Gly Arg Ala  Ala Gln Arg 
    2750                 2755                 2760             


Leu Gln  Asp Thr Ser Ser Tyr  Ala Lys Ile Leu Thr  Cys Pro Lys 
    2765                 2770                 2775             


Thr Lys  Leu Lys Ile Ser Tyr  Lys Asp Ala Ile Asn  Arg Ser Met 
    2780                 2785                 2790             


Val Glu  Asp Ile Thr Gly Leu  Arg Leu Leu Glu Ala  Ala Ser Val 
    2795                 2800                 2805             


Ser Ser  Lys Gly Leu Pro Ser  Pro Tyr Asn Met Ser  Ser Ala Pro 
    2810                 2815                 2820             


Gly Ser  Arg Ser Gly Ser Arg  Ser Gly Ser Arg Ser  Gly Ser Arg 
    2825                 2830                 2835             


Ser Gly  Ser Arg Ser Gly Ser  Arg Arg Gly Ser Phe  Asp Ala Thr 
    2840                 2845                 2850             


Gly Asn  Ser Ser Tyr Ser Tyr  Ser Tyr Ser Phe Ser  Ser Ser Ser 
    2855                 2860                 2865             


Ile Gly  His 
    2870     


<210>  32
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Ser Gly Val Gln Val Ala Asp Glu Val Cys Arg Ile Phe Tyr 
1               5                   10                  15      


Asp Met Lys Val Arg Lys Cys Ser Thr Pro Glu Glu Ile Lys Lys Arg 
            20                  25                  30          


Lys Lys Ala Val Ile Phe Cys Leu Ser Ala Asp Lys Lys Cys Ile Ile 
        35                  40                  45              


Val Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Val Thr Ile 
    50                  55                  60                  


Thr Asp Pro Phe Lys His Phe Val Gly Met Leu Pro Glu Lys Asp Cys 
65                  70                  75                  80  


Arg Tyr Ala Leu Tyr Asp Ala Ser Phe Glu Thr Lys Glu Ser Arg Lys 
                85                  90                  95      


Glu Glu Leu Met Phe Phe Leu Trp Ala Pro Glu Leu Ala Pro Leu Lys 
            100                 105                 110         


Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Phe 
        115                 120                 125             


Gln Gly Ile Lys His Glu Cys Gln Ala Asn Gly Pro Glu Asp Leu Asn 
    130                 135                 140                 


Arg Ala Cys Ile Ala Glu Lys Leu Gly Gly Ser Leu Ile Val Ala Phe 
145                 150                 155                 160 


Glu Gly Cys Pro Val 
                165 


<210>  33
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Thr Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Thr Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Thr Met Ala Ser Phe Leu Lys Gly Ala His 
            100                 105                 110         


Val Thr Ile Asn Ala Arg Ala Glu Glu Asp Val Glu Pro Glu Cys Ile 
        115                 120                 125             


Met Glu Lys Val Ala Lys Ala Ser Gly Ala Asn Tyr Ser Phe His Lys 
    130                 135                 140                 


Glu Ser Gly Arg Phe Gln Asp Val Gly Pro Gln Ala Pro Val Gly Ser 
145                 150                 155                 160 


Val Tyr Gln Lys Thr Asn Ala Val Ser Glu Ile Lys Arg Val Gly Lys 
                165                 170                 175     


Asp Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg Leu 
            180                 185                 190         


Glu Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln Glu 
        195                 200                 205             


Arg Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg Tyr 
    210                 215                 220                 


Gln Glu Gln Gly Gly Glu Ala Ser Pro Gln Arg Thr Trp Glu Gln Gln 
225                 230                 235                 240 


Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Glu Ser Ala Val His 
                245                 250                 255     


Pro Arg Glu Ile Phe Lys Gln Lys Glu Arg Ala Met Ser Thr Thr Ser 
            260                 265                 270         


Ile Ser Ser Pro Gln Pro Gly Lys Leu Arg Ser Pro Phe Leu Gln Lys 
        275                 280                 285             


Gln Leu Thr Gln Pro Glu Thr His Phe Gly Arg Glu Pro Ala Ala Ala 
    290                 295                 300                 


Ile Ser Arg Pro Arg Ala Asp Leu Pro Ala Glu Glu Pro Ala Pro Ser 
305                 310                 315                 320 


Thr Pro Pro Cys Leu Val Gln Ala Glu Glu Glu Ala Val Tyr Glu Glu 
                325                 330                 335     


Pro Pro Glu Gln Glu Thr Phe Tyr Glu Gln Pro Pro Leu Val Gln Gln 
            340                 345                 350         


Gln Gly Ala Gly Ser Glu His Ile Asp His His Ile Gln Gly Gln Gly 
        355                 360                 365             


Leu Ser Gly Gln Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr Gln Ala 
    370                 375                 380                 


Ala Asp Asp Thr Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile Thr Gly 
385                 390                 395                 400 


Ile Glu Val Ile Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro Asp Gly 
                405                 410                 415     


His Phe Gly Met Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
            420                 425                 430 


<210>  34
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Gly Phe Gly Asp Leu Lys Ser Pro Ala Gly Leu Gln Val Leu Asn 
1               5                   10                  15      


Asp Tyr Leu Ala Asp Lys Ser Tyr Ile Glu Gly Tyr Val Pro Ser Gln 
            20                  25                  30          


Ala Asp Val Ala Val Phe Glu Ala Val Ser Ser Pro Pro Pro Ala Asp 
        35                  40                  45              


Leu Cys His Ala Leu Arg Trp Tyr Asn His Ile Lys Ser Tyr Glu Lys 
    50                  55                  60                  


Glu Lys Ala Ser Leu Pro Gly Val Lys Lys Ala Leu Gly Lys Tyr Gly 
65                  70                  75                  80  


Pro Ala Asp Val Glu Asp Thr Thr Gly Ser Gly Ala Thr Asp Ser Lys 
                85                  90                  95      


Asp Asp Asp Asp Ile Asp Leu Phe Gly Ser Asp Asp Glu Glu Glu Ser 
            100                 105                 110         


Glu Glu Ala Lys Arg Leu Arg Glu Glu Arg Leu Ala Gln Tyr Glu Ser 
        115                 120                 125             


Lys Lys Ala Lys Lys Pro Ala Leu Val Ala Lys Ser Ser Ile Leu Leu 
    130                 135                 140                 


Asp Val Lys Pro Trp Asp Asp Glu Thr Asp Met Ala Lys Leu Glu Glu 
145                 150                 155                 160 


Cys Val Arg Ser Ile Gln Ala Asp Gly Leu Val Trp Gly Ser Ser Lys 
                165                 170                 175     


Leu Val Pro Val Gly Tyr Gly Ile Lys Lys Leu Gln Ile Gln Cys Val 
            180                 185                 190         


Val Glu Asp Asp Lys Val Gly Thr Asp Met Leu Glu Glu Gln Ile Thr 
        195                 200                 205             


Ala Phe Glu Asp Tyr Val Gln Ser Met Asp Val Ala Ala Phe Asn Lys 
    210                 215                 220                 


Ile 
225 


<210>  35
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Asn Ala Val Ile Ser Ala Ser Ala Ser Phe Phe Leu Asp Lys Met 
1               5                   10                  15      


Ala Thr Pro Ala Val Pro Val Ser Ala Pro Pro Ala Thr Pro Thr Pro 
            20                  25                  30          


Val Pro Ala Ala Ala Pro Ala Ser Val Pro Ala Pro Thr Pro Ala Pro 
        35                  40                  45              


Ala Ala Ala Pro Val Pro Ala Ala Ala Pro Ala Ser Ser Ser Asp Pro 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Thr Ala Ala Pro Gly Gln Thr Pro Ala Ser 
65                  70                  75                  80  


Ala Gln Ala Pro Ala Gln Thr Pro Ala Pro Ala Leu Pro Gly Pro Ala 
                85                  90                  95      


Leu Pro Gly Pro Phe Pro Gly Gly Arg Val Val Arg Leu His Pro Val 
            100                 105                 110         


Ile Leu Ala Ser Ile Val Asp Ser Tyr Glu Arg Arg Asn Glu Gly Ala 
        115                 120                 125             


Ala Arg Val Ile Gly Thr Leu Leu Gly Thr Val Asp Lys His Ser Val 
    130                 135                 140                 


Glu Val Thr Asn Cys Phe Ser Val Pro His Asn Glu Ser Glu Asp Glu 
145                 150                 155                 160 


Val Ala Val Asp Met Glu Phe Ala Lys Asn Met Tyr Glu Leu His Lys 
                165                 170                 175     


Lys Val Ser Pro Asn Glu Leu Ile Leu Gly Trp Tyr Ala Thr Gly His 
            180                 185                 190         


Asp Ile Thr Glu His Ser Val Leu Ile His Glu Tyr Tyr Ser Arg Glu 
        195                 200                 205             


Ala Pro Asn Pro Ile His Leu Thr Val Asp Thr Ser Leu Gln Asn Gly 
    210                 215                 220                 


Arg Met Ser Ile Lys Ala Tyr Val Ser Thr Leu Met Gly Val Pro Gly 
225                 230                 235                 240 


Arg Thr Met Gly Val Met Phe Thr Pro Leu Thr Val Lys Tyr Ala Tyr 
                245                 250                 255     


Tyr Asp Thr Glu Arg Ile Gly Val Asp Leu Ile Met Lys Thr Cys Phe 
            260                 265                 270         


Ser Pro Asn Arg Val Ile Gly Leu Ser Ser Asp Leu Gln Gln Val Gly 
        275                 280                 285             


Gly Ala Ser Ala Arg Ile Gln Asp Ala Leu Ser Thr Val Leu Gln Tyr 
    290                 295                 300                 


Ala Glu Asp Val Leu Ser Gly Lys Val Ser Ala Asp Asn Thr Val Gly 
305                 310                 315                 320 


Arg Phe Leu Met Ser Leu Val Asn Gln Val Pro Lys Ile Val Pro Asp 
                325                 330                 335     


Asp Phe Glu Thr Met Leu Asn Ser Asn Ile Asn Asp Leu Leu Met Val 
            340                 345                 350         


Thr Tyr Leu Ala Asn Leu Thr Gln Ser Gln Ile Ala Leu Asn Glu Lys 
        355                 360                 365             


Leu Val Asn Leu 
    370         


<210>  36
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gly Asn Leu Leu Lys Val Leu Thr Cys Thr Asp Leu Glu Gln Gly 
1               5                   10                  15      


Pro Asn Phe Phe Leu Asp Phe Glu Asn Ala Gln Pro Thr Glu Ser Glu 
            20                  25                  30          


Lys Glu Ile Tyr Asn Gln Val Asn Val Val Leu Lys Asp Ala Glu Gly 
        35                  40                  45              


Ile Leu Glu Asp Leu Gln Ser Tyr Arg Gly Ala Gly His Glu Ile Arg 
    50                  55                  60                  


Glu Ala Ile Gln His Pro Ala Asp Glu Lys Leu Gln Glu Lys Ala Trp 
65                  70                  75                  80  


Gly Ala Val Val Pro Leu Val Gly Lys Leu Lys Lys Phe Tyr Glu Phe 
                85                  90                  95      


Ser Gln Arg Leu Glu Ala Ala Leu Arg Gly Leu Leu Gly Ala Leu Thr 
            100                 105                 110         


Ser Thr Pro Tyr Ser Pro Thr Gln His Leu Glu Arg Glu Gln Ala Leu 
        115                 120                 125             


Ala Lys Gln Phe Ala Glu Ile Leu His Phe Thr Leu Arg Phe Asp Glu 
    130                 135                 140                 


Leu Lys Met Thr Asn Pro Ala Ile Gln Asn Asp Phe Ser Tyr Tyr Arg 
145                 150                 155                 160 


Arg Thr Leu Ser Arg Met Arg Ile Asn Asn Val Pro Ala Glu Gly Glu 
                165                 170                 175     


Asn Glu Val Asn Asn Glu Leu Ala Asn Arg Met Ser Leu Phe Tyr Ala 
            180                 185                 190         


Glu Ala Thr Pro Met Leu Lys Thr Leu Ser Asp Ala Thr Thr Lys Phe 
        195                 200                 205             


Val Ser Glu Asn Lys Asn Leu Pro Ile Glu Asn Thr Thr Asp Cys Leu 
    210                 215                 220                 


Ser Thr Met Ala Ser Val Cys Arg Val Met Leu Glu Thr Pro Glu Tyr 
225                 230                 235                 240 


Arg Ser Arg Phe Thr Asn Glu Glu Thr Val Ser Phe Cys Leu Arg Val 
                245                 250                 255     


Met Val Gly Val Ile Ile Leu Tyr Asp His Val His Pro Val Gly Ala 
            260                 265                 270         


Phe Ala Lys Thr Ser Lys Ile Asp Met Lys Gly Cys Ile Lys Val Leu 
        275                 280                 285             


Lys Asp Gln Pro Pro Asn Ser Val Glu Gly Leu Leu Asn Ala Leu Arg 
    290                 295                 300                 


Tyr Thr Thr Lys His Leu Asn Asp Glu Thr Thr Ser Lys Gln Ile Lys 
305                 310                 315                 320 


Ser Met Leu Gln 
                


<210>  37
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Tyr Arg Ala Leu Arg Leu Leu Ala Arg Ser Arg Pro Leu Val Arg 
1               5                   10                  15      


Ala Pro Ala Ala Ala Leu Ala Ser Ala Pro Gly Leu Gly Gly Ala Ala 
            20                  25                  30          


Val Pro Ser Phe Trp Pro Pro Asn Ala Ala Arg Met Ala Ser Gln Asn 
        35                  40                  45              


Ser Phe Arg Ile Glu Tyr Asp Thr Phe Gly Glu Leu Lys Val Pro Asn 
    50                  55                  60                  


Asp Lys Tyr Tyr Gly Ala Gln Thr Val Arg Ser Thr Met Asn Phe Lys 
65                  70                  75                  80  


Ile Gly Gly Val Thr Glu Arg Met Pro Thr Pro Val Ile Lys Ala Phe 
                85                  90                  95      


Gly Ile Leu Lys Arg Ala Ala Ala Glu Val Asn Gln Asp Tyr Gly Leu 
            100                 105                 110         


Asp Pro Lys Ile Ala Asn Ala Ile Met Lys Ala Ala Asp Glu Val Ala 
        115                 120                 125             


Glu Gly Lys Leu Asn Asp His Phe Pro Leu Val Val Trp Gln Thr Gly 
    130                 135                 140                 


Ser Gly Thr Gln Thr Asn Met Asn Val Asn Glu Val Ile Ser Asn Arg 
145                 150                 155                 160 


Ala Ile Glu Met Leu Gly Gly Glu Leu Gly Ser Lys Ile Pro Val His 
                165                 170                 175     


Pro Asn Asp His Val Asn Lys Ser Gln Ser Ser Asn Asp Thr Phe Pro 
            180                 185                 190         


Thr Ala Met His Ile Ala Ala Ala Ile Glu Val His Glu Val Leu Leu 
        195                 200                 205             


Pro Gly Leu Gln Lys Leu His Asp Ala Leu Asp Ala Lys Ser Lys Glu 
    210                 215                 220                 


Phe Ala Gln Ile Ile Lys Ile Gly Arg Thr His Thr Gln Asp Ala Val 
225                 230                 235                 240 


Pro Leu Thr Leu Gly Gln Glu Phe Ser Gly Tyr Val Gln Gln Val Lys 
                245                 250                 255     


Tyr Ala Met Thr Arg Ile Lys Ala Ala Met Pro Arg Ile Tyr Glu Leu 
            260                 265                 270         


Ala Ala Gly Gly Thr Ala Val Gly Thr Gly Leu Asn Thr Arg Ile Gly 
        275                 280                 285             


Phe Ala Glu Lys Val Ala Ala Lys Val Ala Ala Leu Thr Gly Leu Pro 
    290                 295                 300                 


Phe Val Thr Ala Pro Asn Lys Phe Glu Ala Leu Ala Ala His Asp Ala 
305                 310                 315                 320 


Leu Val Glu Leu Ser Gly Ala Met Asn Thr Thr Ala Cys Ser Leu Met 
                325                 330                 335     


Lys Ile Ala Asn Asp Ile Arg Phe Leu Gly Ser Gly Pro Arg Ser Gly 
            340                 345                 350         


Leu Gly Glu Leu Ile Leu Pro Glu Asn Glu Pro Gly Ser Ser Ile Met 
        355                 360                 365             


Pro Gly Lys Val Asn Pro Thr Gln Cys Glu Ala Met Thr Met Val Ala 
    370                 375                 380                 


Ala Gln Val Met Gly Asn His Val Ala Val Thr Val Gly Gly Ser Asn 
385                 390                 395                 400 


Gly His Phe Glu Leu Asn Val Phe Lys Pro Met Met Ile Lys Asn Val 
                405                 410                 415     


Leu His Ser Ala Arg Leu Leu Gly Asp Ala Ser Val Ser Phe Thr Glu 
            420                 425                 430         


Asn Cys Val Val Gly Ile Gln Ala Asn Thr Glu Arg Ile Asn Lys Leu 
        435                 440                 445             


Met Asn Glu Ser Leu Met Leu Val Thr Ala Leu Asn Pro His Ile Gly 
    450                 455                 460                 


Tyr Asp Lys Ala Ala Lys Ile Ala Lys Thr Ala His Lys Asn Gly Ser 
465                 470                 475                 480 


Thr Leu Lys Glu Thr Ala Ile Glu Leu Gly Tyr Leu Thr Ala Glu Gln 
                485                 490                 495     


Phe Asp Glu Trp Val Lys Pro Lys Asp Met Leu Gly Pro Lys 
            500                 505                 510 


<210>  38
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ser Gly Arg Ser Gly Lys Lys Lys Met Ser Lys Leu Ser Arg Ser 
1               5                   10                  15      


Ala Arg Ala Gly Val Ile Phe Pro Val Gly Arg Leu Met Arg Tyr Leu 
            20                  25                  30          


Lys Lys Gly Thr Phe Lys Tyr Arg Ile Ser Val Gly Ala Pro Val Tyr 
        35                  40                  45              


Met Ala Ala Val Ile Glu Tyr Leu Ala Ala Glu Ile Leu Glu Leu Ala 
    50                  55                  60                  


Gly Asn Ala Ala Arg Asp Asn Lys Lys Ala Arg Ile Ala Pro Arg His 
65                  70                  75                  80  


Ile Leu Leu Ala Val Ala Asn Asp Glu Glu Leu Asn Gln Leu Leu Lys 
                85                  90                  95      


Gly Val Thr Ile Ala Ser Gly Gly Val Leu Pro Arg Ile His Pro Glu 
            100                 105                 110         


Leu Leu Ala Lys Lys Arg Gly Thr Lys Gly Lys Ser Glu Thr Ile Leu 
        115                 120                 125             


Ser Pro Pro Pro Glu Lys Arg Gly Arg Lys Ala Thr Ser Gly Lys Lys 
    130                 135                 140                 


Gly Gly Lys Lys Ser Lys Ala Ala Lys Pro Arg Thr Ser Lys Lys Ser 
145                 150                 155                 160 


Lys Pro Lys Asp Ser Asp Lys Glu Gly Thr Ser Asn Ser Thr Ser Glu 
                165                 170                 175     


Asp Gly Pro Gly Asp Gly Phe Thr Ile Leu Ser Ser Lys Ser Leu Val 
            180                 185                 190         


Leu Gly Gln Lys Leu Ser Leu Thr Gln Ser Asp Ile Ser His Ile Gly 
        195                 200                 205             


Ser Met Arg Val Glu Gly Ile Val His Pro Thr Thr Ala Glu Ile Asp 
    210                 215                 220                 


Leu Lys Glu Asp Ile Gly Lys Ala Leu Glu Lys Ala Gly Gly Lys Glu 
225                 230                 235                 240 


Phe Leu Glu Thr Val Lys Glu Leu Arg Lys Ser Gln Gly Pro Leu Glu 
                245                 250                 255     


Val Ala Glu Ala Ala Val Ser Gln Ser Ser Gly Leu Ala Ala Lys Phe 
            260                 265                 270         


Val Ile His Cys His Ile Pro Gln Trp Gly Ser Asp Lys Cys Glu Glu 
        275                 280                 285             


Gln Leu Glu Glu Thr Ile Lys Asn Cys Leu Ser Ala Ala Glu Asp Lys 
    290                 295                 300                 


Lys Leu Lys Ser Val Ala Phe Pro Pro Phe Pro Ser Gly Arg Asn Cys 
305                 310                 315                 320 


Phe Pro Lys Gln Thr Ala Ala Gln Val Thr Leu Lys Ala Ile Ser Ala 
                325                 330                 335     


His Phe Asp Asp Ser Ser Ala Ser Ser Leu Lys Asn Val Tyr Phe Leu 
            340                 345                 350         


Leu Phe Asp Ser Glu Ser Ile Gly Ile Tyr Val Gln Glu Met Ala Lys 
        355                 360                 365             


Leu Asp Ala Lys 
    370         


<210>  39
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Thr Glu Arg Arg Val Pro Phe Ser Leu Leu Arg Gly Pro Ser Trp 
1               5                   10                  15      


Asp Pro Phe Arg Asp Trp Tyr Pro His Ser Arg Leu Phe Asp Gln Ala 
            20                  25                  30          


Phe Gly Leu Pro Arg Leu Pro Glu Glu Trp Ser Gln Trp Leu Gly Gly 
        35                  40                  45              


Ser Ser Trp Pro Gly Tyr Val Arg Pro Leu Pro Pro Ala Ala Ile Glu 
    50                  55                  60                  


Ser Pro Ala Val Ala Ala Pro Ala Tyr Ser Arg Ala Leu Ser Arg Gln 
65                  70                  75                  80  


Leu Ser Ser Gly Val Ser Glu Ile Arg His Thr Ala Asp Arg Trp Arg 
                85                  90                  95      


Val Ser Leu Asp Val Asn His Phe Ala Pro Asp Glu Leu Thr Val Lys 
            100                 105                 110         


Thr Lys Asp Gly Val Val Glu Ile Thr Gly Lys His Glu Glu Arg Gln 
        115                 120                 125             


Asp Glu His Gly Tyr Ile Ser Arg Cys Phe Thr Arg Lys Tyr Thr Leu 
    130                 135                 140                 


Pro Pro Gly Val Asp Pro Thr Gln Val Ser Ser Ser Leu Ser Pro Glu 
145                 150                 155                 160 


Gly Thr Leu Thr Val Glu Ala Pro Met Pro Lys Leu Ala Thr Gln Ser 
                165                 170                 175     


Asn Glu Ile Thr Ile Pro Val Thr Phe Glu Ser Arg Ala Gln Leu Gly 
            180                 185                 190         


Gly Pro Glu Ala Ala Lys Ser Asp Glu Thr Ala Ala Lys 
        195                 200                 205 


<210>  40
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Glu Thr Glu Gln Pro Glu Glu Thr Phe Pro Asn Thr Glu Thr Asn 
1               5                   10                  15      


Gly Glu Phe Gly Lys Arg Pro Ala Glu Asp Met Glu Glu Glu Gln Ala 
            20                  25                  30          


Phe Lys Arg Ser Arg Asn Thr Asp Glu Met Val Glu Leu Arg Ile Leu 
        35                  40                  45              


Leu Gln Ser Lys Asn Ala Gly Ala Val Ile Gly Lys Gly Gly Lys Asn 
    50                  55                  60                  


Ile Lys Ala Leu Arg Thr Asp Tyr Asn Ala Ser Val Ser Val Pro Asp 
65                  70                  75                  80  


Ser Ser Gly Pro Glu Arg Ile Leu Ser Ile Ser Ala Asp Ile Glu Thr 
                85                  90                  95      


Ile Gly Glu Ile Leu Lys Lys Ile Ile Pro Thr Leu Glu Glu Gly Leu 
            100                 105                 110         


Gln Leu Pro Ser Pro Thr Ala Thr Ser Gln Leu Pro Leu Glu Ser Asp 
        115                 120                 125             


Ala Val Glu Cys Leu Asn Tyr Gln His Tyr Lys Gly Ser Asp Phe Asp 
    130                 135                 140                 


Cys Glu Leu Arg Leu Leu Ile His Gln Ser Leu Ala Gly Gly Ile Ile 
145                 150                 155                 160 


Gly Val Lys Gly Ala Lys Ile Lys Glu Leu Arg Glu Asn Thr Gln Thr 
                165                 170                 175     


Thr Ile Lys Leu Phe Gln Glu Cys Cys Pro His Ser Thr Asp Arg Val 
            180                 185                 190         


Val Leu Ile Gly Gly Lys Pro Asp Arg Val Val Glu Cys Ile Lys Ile 
        195                 200                 205             


Ile Leu Asp Leu Ile Ser Glu Ser Pro Ile Lys Gly Arg Ala Gln Pro 
    210                 215                 220                 


Tyr Asp Pro Asn Phe Tyr Asp Glu Thr Tyr Asp Tyr Gly Gly Phe Thr 
225                 230                 235                 240 


Met Met Phe Asp Asp Arg Arg Gly Arg Pro Val Gly Phe Pro Met Arg 
                245                 250                 255     


Gly Arg Gly Gly Phe Asp Arg Met Pro Pro Gly Arg Gly Gly Arg Pro 
            260                 265                 270         


Met Pro Pro Ser Arg Arg Asp Tyr Asp Asp Met Ser Pro Arg Arg Gly 
        275                 280                 285             


Pro Pro Pro Pro Pro Pro Gly Arg Gly Gly Arg Gly Gly Ser Arg Ala 
    290                 295                 300                 


Arg Asn Leu Pro Leu Pro Pro Pro Pro Pro Pro Arg Gly Gly Asp Leu 
305                 310                 315                 320 


Met Ala Tyr Asp Arg Arg Gly Arg Pro Gly Asp Arg Tyr Asp Gly Met 
                325                 330                 335     


Val Gly Phe Ser Ala Asp Glu Thr Trp Asp Ser Ala Ile Asp Thr Trp 
            340                 345                 350         


Ser Pro Ser Glu Trp Gln Met Ala Tyr Glu Pro Gln Gly Gly Ser Gly 
        355                 360                 365             


Tyr Asp Tyr Ser Tyr Ala Gly Gly Arg Gly Ser Tyr Gly Asp Leu Gly 
    370                 375                 380                 


Gly Pro Ile Ile Thr Thr Gln Val Thr Ile Pro Lys Asp Leu Ala Gly 
385                 390                 395                 400 


Ser Ile Ile Gly Lys Gly Gly Gln Arg Ile Lys Gln Ile Arg His Glu 
                405                 410                 415     


Ser Gly Ala Ser Ile Lys Ile Asp Glu Pro Leu Glu Gly Ser Glu Asp 
            420                 425                 430         


Arg Ile Ile Thr Ile Thr Gly Thr Gln Asp Gln Ile Gln Asn Ala Gln 
        435                 440                 445             


Tyr Leu Leu Gln Asn Ser Val Lys Gln Tyr Ser Gly Lys Phe Phe 
    450                 455                 460             


<210>  41
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  41

Gln Arg Gln Gln Pro Asp Glu Gln Arg Arg Arg Ser Gly Ala Met Val 
1               5                   10                  15      


Lys Met Ala Ala Ala Gly Gly Gly Gly Gly Gly Gly Arg Tyr Tyr Gly 
            20                  25                  30          


Gly Gly Ser Glu Gly Gly Arg Ala Pro Lys Arg Leu Lys Thr Asp Asn 
        35                  40                  45              


Ala Gly Asp Gln His Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Ala Ala Gly Gly Gly Gly Gly Gly Glu Asn Tyr Asp Asp Pro His Lys 
65                  70                  75                  80  


Thr Pro Ala Ser Pro Val Val His Ile Arg Gly Leu Ile Asp Gly Val 
                85                  90                  95      


Val Glu Ala Asp Leu Val Glu Ala Leu Gln Glu Phe Gly Pro Ile Ser 
            100                 105                 110         


Tyr Val Val Val Met Pro Lys Lys Arg Gln Ala Leu Val Glu Phe Glu 
        115                 120                 125             


Asp Val Leu Gly Ala Cys Asn Ala Val Asn Tyr Ala Ala Asp Asn Gln 
    130                 135                 140                 


Ile Tyr Ile Ala Gly His Pro Ala Phe Val Asn Tyr Ser Thr Ser Gln 
145                 150                 155                 160 


Lys Ile Ser Arg Pro Gly Asp Ser Asp Asp Ser Arg Ser Val Asn Ser 
                165                 170                 175     


Val Leu Leu Phe Thr Ile Leu Asn Pro Ile Tyr Ser Ile Thr Thr Asp 
            180                 185                 190         


Val Leu Tyr Thr Ile Cys Asn Pro Cys Gly Pro Val Gln Arg Ile Val 
        195                 200                 205             


Ile Phe Arg Lys Asn Gly Val Gln Ala Met Val Glu Phe Asp Ser Val 
    210                 215                 220                 


Gln Ser Ala Gln Arg Ala Lys Ala Ser Leu Asn Gly Ala Asp Ile Tyr 
225                 230                 235                 240 


Ser Gly Cys Cys Thr Leu Lys Ile Glu Tyr Ala Lys Pro Thr Arg Leu 
                245                 250                 255     


Asn Val Phe Lys Asn Asp Gln Asp Thr Trp Asp Tyr Thr Asn Pro Asn 
            260                 265                 270         


Leu Ser Gly Gln Gly Asp Pro Gly Ser Asn Pro Asn Lys Arg Gln Arg 
        275                 280                 285             


Gln Pro Pro Leu Leu Gly Asp His Pro Ala Glu Tyr Gly Gly Pro His 
    290                 295                 300                 


Gly Gly Tyr His Ser His Tyr His Asp Glu Gly Tyr Gly Pro Pro Pro 
305                 310                 315                 320 


Pro His Tyr Glu Gly Arg Arg Met Gly Pro Pro Val Gly Gly His Arg 
                325                 330                 335     


Arg Gly Pro Ser Arg Tyr Gly Pro Gln Tyr Gly His Pro Pro Pro Pro 
            340                 345                 350         


Pro Pro Pro Pro Glu Tyr Gly Pro His Ala Asp Ser Pro Val Leu Met 
        355                 360                 365             


Val Tyr Gly Leu Asp Gln Ser Lys Met Asn Cys Asp Arg Val Phe Asn 
    370                 375                 380                 


Val Phe Cys Leu Tyr Gly Asn Val Glu Lys Val Lys Phe Met Lys Ser 
385                 390                 395                 400 


Lys Pro Gly Ala Ala Met Val Glu Met Ala Asp Gly Tyr Ala Val Asp 
                405                 410                 415     


Arg Ala Ile Thr His Leu Asn Asn Asn Phe Met Phe Gly Gln Lys Leu 
            420                 425                 430         


Asn Val Cys Val Ser Lys Gln Pro Ala Ile Met Pro Gly Gln Ser Tyr 
        435                 440                 445             


Gly Leu Glu Asp Gly Ser Cys Ser Tyr Lys Asp Phe Ser Glu Ser Arg 
    450                 455                 460                 


Asn Asn Arg Phe Ser Thr Pro Glu Gln Ala Ala Lys Asn Arg Ile Gln 
465                 470                 475                 480 


His Pro Ser Asn Val Leu His Phe Phe Asn Ala Pro Leu Glu Val Thr 
                485                 490                 495     


Glu Glu Asn Phe Phe Glu Ile Cys Asp Glu Leu Gly Val Lys Arg Pro 
            500                 505                 510         


Ser Ser Val Lys Val Phe Ser Gly Lys Ser Glu Arg Ser Ser Ser Gly 
        515                 520                 525             


Leu Leu Glu Trp Glu Ser Lys Ser Asp Ala Leu Glu Thr Leu Gly Phe 
    530                 535                 540                 


Leu Asn His Tyr Gln Met Lys Asn Pro Asn Gly Pro Tyr Pro Tyr Thr 
545                 550                 555                 560 


Leu Lys Leu Cys Phe Ser Thr Ala Gln His Ala Ser 
                565                 570         


<210>  42
<211>  730
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Ala Gly Val Glu Ala Ala Ala Glu Val Ala Ala Thr Glu Ile 
1               5                   10                  15      


Lys Met Glu Glu Glu Ser Gly Ala Pro Gly Val Pro Ser Gly Asn Gly 
            20                  25                  30          


Ala Pro Gly Pro Lys Gly Glu Gly Glu Arg Pro Ala Gln Asn Glu Lys 
        35                  40                  45              


Arg Lys Glu Lys Asn Ile Lys Arg Gly Gly Asn Arg Phe Glu Pro Tyr 
    50                  55                  60                  


Ala Asn Pro Thr Lys Arg Tyr Arg Ala Phe Ile Thr Asn Ile Pro Phe 
65                  70                  75                  80  


Asp Val Lys Trp Gln Ser Leu Lys Asp Leu Val Lys Glu Lys Val Gly 
                85                  90                  95      


Glu Val Thr Tyr Val Glu Leu Leu Met Asp Ala Glu Gly Lys Ser Arg 
            100                 105                 110         


Gly Cys Ala Val Val Glu Phe Lys Met Glu Glu Ser Met Lys Lys Ala 
        115                 120                 125             


Ala Glu Val Leu Asn Lys His Ser Leu Ser Gly Arg Pro Leu Lys Val 
    130                 135                 140                 


Lys Glu Asp Pro Asp Gly Glu His Ala Arg Arg Ala Met Gln Lys Val 
145                 150                 155                 160 


Met Ala Thr Thr Gly Gly Met Gly Met Gly Pro Gly Gly Pro Gly Met 
                165                 170                 175     


Ile Thr Ile Pro Pro Ser Ile Leu Asn Asn Pro Asn Ile Pro Asn Glu 
            180                 185                 190         


Ile Ile His Ala Leu Gln Ala Gly Arg Leu Gly Ser Thr Val Phe Val 
        195                 200                 205             


Ala Asn Leu Asp Tyr Lys Val Gly Trp Lys Lys Leu Lys Glu Val Phe 
    210                 215                 220                 


Ser Met Ala Gly Val Val Val Arg Ala Asp Ile Leu Glu Asp Lys Asp 
225                 230                 235                 240 


Gly Lys Ser Arg Gly Ile Gly Thr Val Thr Phe Glu Gln Ser Ile Glu 
                245                 250                 255     


Ala Val Gln Ala Ile Ser Met Phe Asn Gly Gln Leu Leu Phe Asp Arg 
            260                 265                 270         


Pro Met His Val Lys Met Asp Glu Arg Ala Leu Pro Lys Gly Asp Phe 
        275                 280                 285             


Phe Pro Pro Glu Arg Pro Gln Gln Leu Pro His Gly Leu Gly Gly Ile 
    290                 295                 300                 


Gly Met Gly Leu Gly Pro Gly Gly Gln Pro Ile Asp Ala Asn His Leu 
305                 310                 315                 320 


Asn Lys Gly Ile Gly Met Gly Asn Ile Gly Pro Ala Gly Met Gly Met 
                325                 330                 335     


Glu Gly Ile Gly Phe Gly Ile Asn Lys Met Gly Gly Met Glu Gly Pro 
            340                 345                 350         


Phe Gly Gly Gly Met Glu Asn Met Gly Arg Phe Gly Ser Gly Met Asn 
        355                 360                 365             


Met Gly Arg Ile Asn Glu Ile Leu Ser Asn Ala Leu Lys Arg Gly Glu 
    370                 375                 380                 


Ile Ile Ala Lys Gln Gly Gly Gly Gly Gly Gly Gly Ser Val Pro Gly 
385                 390                 395                 400 


Ile Glu Arg Met Gly Pro Gly Ile Asp Arg Leu Gly Gly Ala Gly Met 
                405                 410                 415     


Glu Arg Met Gly Ala Gly Leu Gly His Gly Met Asp Arg Val Gly Ser 
            420                 425                 430         


Glu Ile Glu Arg Met Gly Leu Val Met Asp Arg Met Gly Ser Val Glu 
        435                 440                 445             


Arg Met Gly Ser Gly Ile Glu Arg Met Gly Pro Leu Gly Leu Asp His 
    450                 455                 460                 


Met Ala Ser Ser Ile Glu Arg Met Gly Gln Thr Met Glu Arg Ile Gly 
465                 470                 475                 480 


Ser Gly Val Glu Arg Met Gly Ala Gly Met Gly Phe Gly Leu Glu Arg 
                485                 490                 495     


Met Ala Ala Pro Ile Asp Arg Val Gly Gln Thr Ile Glu Arg Met Gly 
            500                 505                 510         


Ser Gly Val Glu Arg Met Gly Pro Ala Ile Glu Arg Met Gly Leu Ser 
        515                 520                 525             


Met Glu Arg Met Val Pro Ala Gly Met Gly Ala Gly Leu Glu Arg Met 
    530                 535                 540                 


Gly Pro Val Met Asp Arg Met Ala Thr Gly Leu Glu Arg Met Gly Ala 
545                 550                 555                 560 


Asn Asn Leu Glu Arg Met Gly Leu Glu Arg Met Gly Ala Asn Ser Leu 
                565                 570                 575     


Glu Arg Met Gly Leu Glu Arg Met Gly Ala Asn Ser Leu Glu Arg Met 
            580                 585                 590         


Gly Pro Ala Met Gly Pro Ala Leu Gly Ala Gly Ile Glu Arg Met Gly 
        595                 600                 605             


Leu Ala Met Gly Gly Gly Gly Gly Ala Ser Phe Asp Arg Ala Ile Glu 
    610                 615                 620                 


Met Glu Arg Gly Asn Phe Gly Gly Ser Phe Ala Gly Ser Phe Gly Gly 
625                 630                 635                 640 


Ala Gly Gly His Ala Pro Gly Val Ala Arg Lys Ala Cys Gln Ile Phe 
                645                 650                 655     


Val Arg Asn Leu Pro Phe Asp Phe Thr Trp Lys Met Leu Lys Asp Lys 
            660                 665                 670         


Phe Asn Glu Cys Gly His Val Leu Tyr Ala Asp Ile Lys Met Glu Asn 
        675                 680                 685             


Gly Lys Ser Lys Gly Cys Gly Val Val Lys Phe Glu Ser Pro Glu Val 
    690                 695                 700                 


Ala Glu Arg Ala Cys Arg Met Met Asn Gly Met Lys Leu Ser Gly Arg 
705                 710                 715                 720 


Glu Ile Asp Val Arg Ile Asp Arg Asn Ala 
                725                 730 


<210>  43
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ala Asn Gln Val Asn Gly Asn Ala Val Gln Leu Lys Glu Glu Glu 
1               5                   10                  15      


Glu Pro Met Asp Thr Ser Ser Val Thr His Thr Glu His Tyr Lys Thr 
            20                  25                  30          


Leu Ile Glu Ala Gly Leu Pro Gln Lys Val Ala Glu Arg Leu Asp Glu 
        35                  40                  45              


Ile Phe Gln Thr Gly Leu Val Ala Tyr Val Asp Leu Asp Glu Arg Ala 
    50                  55                  60                  


Ile Asp Ala Leu Arg Glu Phe Asn Glu Glu Gly Ala Leu Ser Val Leu 
65                  70                  75                  80  


Gln Gln Phe Lys Glu Ser Asp Leu Ser His Val Gln Asn Lys Ser Ala 
                85                  90                  95      


Phe Leu Cys Gly Val Met Lys Thr Tyr Arg Gln Arg Glu Lys Gln Gly 
            100                 105                 110         


Ser Lys Val Gln Glu Ser Thr Lys Gly Pro Asp Glu Ala Lys Ile Lys 
        115                 120                 125             


Ala Leu Leu Glu Arg Thr Gly Tyr Thr Leu Asp Val Thr Thr Gly Gln 
    130                 135                 140                 


Arg Lys Tyr Gly Gly Pro Pro Pro Asp Ser Val Tyr Ser Gly Val Gln 
145                 150                 155                 160 


Pro Gly Ile Gly Thr Glu Val Phe Val Gly Lys Ile Pro Arg Asp Leu 
                165                 170                 175     


Tyr Glu Asp Glu Leu Val Pro Leu Phe Glu Lys Ala Gly Pro Ile Trp 
            180                 185                 190         


Asp Leu Arg Leu Met Met Asp Pro Leu Ser Gly Gln Asn Arg Gly Tyr 
        195                 200                 205             


Ala Phe Ile Thr Phe Cys Gly Lys Glu Ala Ala Gln Glu Ala Val Lys 
    210                 215                 220                 


Leu Cys Asp Ser Tyr Glu Ile Arg Pro Gly Lys His Leu Gly Val Cys 
225                 230                 235                 240 


Ile Ser Val Ala Asn Asn Arg Leu Phe Val Gly Ser Ile Pro Lys Asn 
                245                 250                 255     


Lys Thr Lys Glu Asn Ile Leu Glu Glu Phe Ser Lys Val Thr Glu Gly 
            260                 265                 270         


Leu Val Asp Val Ile Leu Tyr His Gln Pro Asp Asp Lys Lys Lys Asn 
        275                 280                 285             


Arg Gly Phe Cys Phe Leu Glu Tyr Glu Asp His Lys Ser Ala Ala Gln 
    290                 295                 300                 


Ala Arg Arg Arg Leu Met Ser Gly Lys Val Lys Val Trp Gly Asn Val 
305                 310                 315                 320 


Val Thr Val Glu Trp Ala Asp Pro Val Glu Glu Pro Asp Pro Glu Val 
                325                 330                 335     


Met Ala Lys Val Lys Val Leu Phe Val Arg Asn Leu Ala Thr Thr Val 
            340                 345                 350         


Thr Glu Glu Ile Leu Glu Lys Ser Phe Ser Glu Phe Gly Lys Leu Glu 
        355                 360                 365             


Arg Val Lys Lys Leu Lys Asp Tyr Ala Phe Val His Phe Glu Asp Arg 
    370                 375                 380                 


Gly Ala Ala Val Lys Ala Met Asp Glu Met Asn Gly Lys Glu Ile Glu 
385                 390                 395                 400 


Gly Glu Glu Ile Glu Ile Val Leu Ala Lys Pro Pro Asp Lys Lys Arg 
                405                 410                 415     


Lys Glu Arg Gln Ala Ala Arg Gln Ala Ser Arg Ser Thr Ala Tyr Glu 
            420                 425                 430         


Asp Tyr Tyr Tyr His Pro Pro Pro Arg Met Pro Pro Pro Ile Arg Gly 
        435                 440                 445             


Arg Gly Arg Gly Gly Gly Arg Gly Gly Tyr Gly Tyr Pro Pro Asp Tyr 
    450                 455                 460                 


Tyr Gly Tyr Glu Asp Tyr Tyr Asp Asp Tyr Tyr Gly Tyr Asp Tyr His 
465                 470                 475                 480 


Asp Tyr Arg Gly Gly Tyr Glu Asp Pro Tyr Tyr Gly Tyr Asp Asp Gly 
                485                 490                 495     


Tyr Ala Val Arg Gly Arg Gly Gly Gly Arg Gly Gly Arg Gly Ala Pro 
            500                 505                 510         


Pro Pro Pro Arg Gly Arg Gly Ala Pro Pro Pro Arg Gly Arg Ala Gly 
        515                 520                 525             


Tyr Ser Gln Arg Gly Ala Pro Leu Gly Pro Pro Arg Gly Ser Arg Gly 
    530                 535                 540                 


Gly Arg Gly Gly Pro Ala Gln Gln Gln Arg Gly Arg Gly Ser Arg Gly 
545                 550                 555                 560 


Ser Arg Gly Asn Arg Gly Gly Asn Val Gly Gly Lys Arg Lys Ala Asp 
                565                 570                 575     


Gly Tyr Asn Gln Pro Asp Ser Lys Arg Arg Gln Thr Asn Asn Gln Gln 
            580                 585                 590         


Asn Trp Gly Ser Gln Pro Ile Ala Gln Gln Pro Leu Gln Gln Gly Gly 
        595                 600                 605             


Asp Tyr Ser Gly Asn Tyr Gly Tyr Asn Asn Asp Asn Gln Glu Phe Tyr 
    610                 615                 620                 


Gln Asp Thr Tyr Gly Gln Gln Trp Lys 
625                 630             


<210>  44
<211>  856
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Asp Val Arg Arg Leu Lys Val Asn Glu Leu Arg Glu Glu Leu Gln 
1               5                   10                  15      


Arg Arg Gly Leu Asp Thr Arg Gly Leu Lys Ala Glu Leu Ala Glu Arg 
            20                  25                  30          


Leu Gln Ala Ala Leu Glu Ala Glu Glu Pro Asp Asp Glu Arg Glu Leu 
        35                  40                  45              


Asp Ala Asp Asp Glu Pro Gly Arg Pro Gly His Ile Asn Glu Glu Val 
    50                  55                  60                  


Glu Thr Glu Gly Gly Ser Glu Leu Glu Gly Thr Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Pro Gly Leu Gln Pro His Ala Glu Pro Gly Gly Tyr Ser Gly Pro Asp 
                85                  90                  95      


Gly His Tyr Ala Met Asp Asn Ile Thr Arg Gln Asn Gln Phe Tyr Asp 
            100                 105                 110         


Thr Gln Val Ile Lys Gln Glu Asn Glu Ser Gly Tyr Glu Arg Arg Pro 
        115                 120                 125             


Leu Glu Met Glu Gln Gln Gln Ala Tyr Arg Pro Glu Met Lys Thr Glu 
    130                 135                 140                 


Met Lys Gln Gly Ala Pro Thr Ser Phe Leu Pro Pro Glu Ala Ser Gln 
145                 150                 155                 160 


Leu Lys Pro Asp Arg Gln Gln Phe Gln Ser Arg Lys Arg Pro Tyr Glu 
                165                 170                 175     


Glu Asn Arg Gly Arg Gly Tyr Phe Glu His Arg Glu Asp Arg Arg Gly 
            180                 185                 190         


Arg Ser Pro Gln Pro Pro Ala Glu Glu Asp Glu Asp Asp Phe Asp Asp 
        195                 200                 205             


Thr Leu Val Ala Ile Asp Thr Tyr Asn Cys Asp Leu His Phe Lys Val 
    210                 215                 220                 


Ala Arg Asp Arg Ser Ser Gly Tyr Pro Leu Thr Ile Glu Gly Phe Ala 
225                 230                 235                 240 


Tyr Leu Trp Ser Gly Ala Arg Ala Ser Tyr Gly Val Arg Arg Gly Arg 
                245                 250                 255     


Val Cys Phe Glu Met Lys Ile Asn Glu Glu Ile Ser Val Lys His Leu 
            260                 265                 270         


Pro Ser Thr Glu Pro Asp Pro His Val Val Arg Ile Gly Trp Ser Leu 
        275                 280                 285             


Asp Ser Cys Ser Thr Gln Leu Gly Glu Glu Pro Phe Ser Tyr Gly Tyr 
    290                 295                 300                 


Gly Gly Thr Gly Lys Lys Ser Thr Asn Ser Arg Phe Glu Asn Tyr Gly 
305                 310                 315                 320 


Asp Lys Phe Ala Glu Asn Asp Val Ile Gly Cys Phe Ala Asp Phe Glu 
                325                 330                 335     


Cys Gly Asn Asp Val Glu Leu Ser Phe Thr Lys Asn Gly Lys Trp Met 
            340                 345                 350         


Gly Ile Ala Phe Arg Ile Gln Lys Glu Ala Leu Gly Gly Gln Ala Leu 
        355                 360                 365             


Tyr Pro His Val Leu Val Lys Asn Cys Ala Val Glu Phe Asn Phe Gly 
    370                 375                 380                 


Gln Arg Ala Glu Pro Tyr Cys Ser Val Leu Pro Gly Phe Thr Phe Ile 
385                 390                 395                 400 


Gln His Leu Pro Leu Ser Glu Arg Ile Arg Gly Thr Val Gly Pro Lys 
                405                 410                 415     


Ser Lys Ala Glu Cys Glu Ile Leu Met Met Val Gly Leu Pro Ala Ala 
            420                 425                 430         


Gly Lys Thr Thr Trp Ala Ile Lys His Ala Ala Ser Asn Pro Ser Lys 
        435                 440                 445             


Lys Tyr Asn Ile Leu Gly Thr Asn Ala Ile Met Asp Lys Met Arg Val 
    450                 455                 460                 


Met Gly Leu Arg Arg Gln Arg Asn Tyr Ala Gly Arg Trp Asp Val Leu 
465                 470                 475                 480 


Ile Gln Gln Ala Thr Gln Cys Leu Asn Arg Leu Ile Gln Ile Ala Ala 
                485                 490                 495     


Arg Lys Lys Arg Asn Tyr Ile Leu Asp Gln Thr Asn Val Tyr Gly Ser 
            500                 505                 510         


Ala Gln Arg Arg Lys Met Arg Pro Phe Glu Gly Phe Gln Arg Lys Ala 
        515                 520                 525             


Ile Val Ile Cys Pro Thr Asp Glu Asp Leu Lys Asp Arg Thr Ile Lys 
    530                 535                 540                 


Arg Thr Asp Glu Glu Gly Lys Asp Val Pro Asp His Ala Val Leu Glu 
545                 550                 555                 560 


Met Lys Ala Asn Phe Thr Leu Pro Asp Val Gly Asp Phe Leu Asp Glu 
                565                 570                 575     


Val Leu Phe Ile Glu Leu Gln Arg Glu Glu Ala Asp Lys Leu Val Arg 
            580                 585                 590         


Gln Tyr Asn Glu Glu Gly Arg Lys Ala Gly Pro Pro Pro Glu Lys Arg 
        595                 600                 605             


Phe Asp Asn Arg Gly Gly Gly Gly Phe Arg Gly Arg Gly Gly Gly Gly 
    610                 615                 620                 


Gly Phe Gln Arg Tyr Glu Asn Arg Gly Pro Pro Gly Gly Asn Arg Gly 
625                 630                 635                 640 


Gly Phe Gln Asn Arg Gly Gly Gly Ser Gly Gly Gly Gly Asn Tyr Arg 
                645                 650                 655     


Gly Gly Phe Asn Arg Ser Gly Gly Gly Gly Tyr Ser Gln Asn Arg Trp 
            660                 665                 670         


Gly Asn Asn Asn Arg Asp Asn Asn Asn Ser Asn Asn Arg Gly Ser Tyr 
        675                 680                 685             


Asn Arg Ala Pro Gln Gln Gln Pro Pro Pro Gln Gln Pro Pro Pro Pro 
    690                 695                 700                 


Gln Pro Pro Pro Gln Gln Pro Pro Pro Pro Pro Ser Tyr Ser Pro Ala 
705                 710                 715                 720 


Arg Asn Pro Pro Gly Ala Ser Thr Tyr Asn Lys Asn Ser Asn Ile Pro 
                725                 730                 735     


Gly Ser Ser Ala Asn Thr Ser Thr Pro Thr Val Ser Ser Tyr Ser Pro 
            740                 745                 750         


Pro Gln Pro Ser Tyr Ser Gln Pro Pro Tyr Asn Gln Gly Gly Tyr Ser 
        755                 760                 765             


Gln Gly Tyr Thr Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Tyr 
    770                 775                 780                 


Asn Tyr Gly Ser Tyr Gly Gly Tyr Asn Pro Ala Pro Tyr Thr Pro Pro 
785                 790                 795                 800 


Pro Pro Pro Thr Ala Gln Thr Tyr Pro Gln Pro Ser Tyr Asn Gln Tyr 
                805                 810                 815     


Gln Gln Tyr Ala Gln Gln Trp Asn Gln Tyr Tyr Gln Asn Gln Gly Gln 
            820                 825                 830         


Trp Pro Pro Tyr Tyr Gly Asn Tyr Asp Tyr Gly Ser Tyr Ser Gly Asn 
        835                 840                 845             


Thr Gln Gly Gly Thr Ser Thr Gln 
    850                 855     


<210>  45
<211>  736
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Gly Ser Pro Leu Arg Phe Asp Gly Arg Val Val Leu Val Thr Gly 
1               5                   10                  15      


Ala Gly Ala Gly Leu Gly Arg Ala Tyr Ala Leu Ala Phe Ala Glu Arg 
            20                  25                  30          


Gly Ala Leu Val Val Val Asn Asp Leu Gly Gly Asp Phe Lys Gly Val 
        35                  40                  45              


Gly Lys Gly Ser Leu Ala Ala Asp Lys Val Val Glu Glu Ile Arg Arg 
    50                  55                  60                  


Arg Gly Gly Lys Ala Val Ala Asn Tyr Asp Ser Val Glu Glu Gly Glu 
65                  70                  75                  80  


Lys Val Val Lys Thr Ala Leu Asp Ala Phe Gly Arg Ile Asp Val Val 
                85                  90                  95      


Val Asn Asn Ala Gly Ile Leu Arg Asp Arg Ser Phe Ala Arg Ile Ser 
            100                 105                 110         


Asp Glu Asp Trp Asp Ile Ile His Arg Val His Leu Arg Gly Ser Phe 
        115                 120                 125             


Gln Val Thr Arg Ala Ala Trp Glu His Met Lys Lys Gln Lys Tyr Gly 
    130                 135                 140                 


Arg Ile Ile Met Thr Ser Ser Ala Ser Gly Ile Tyr Gly Asn Phe Gly 
145                 150                 155                 160 


Gln Ala Asn Tyr Ser Ala Ala Lys Leu Gly Leu Leu Gly Leu Ala Asn 
                165                 170                 175     


Ser Leu Ala Ile Glu Gly Arg Lys Ser Asn Ile His Cys Asn Thr Ile 
            180                 185                 190         


Ala Pro Asn Ala Gly Ser Arg Met Thr Gln Thr Val Met Pro Glu Asp 
        195                 200                 205             


Leu Val Glu Ala Leu Lys Pro Glu Tyr Val Ala Pro Leu Val Leu Trp 
    210                 215                 220                 


Leu Cys His Glu Ser Cys Glu Glu Asn Gly Gly Leu Phe Glu Val Gly 
225                 230                 235                 240 


Ala Gly Trp Ile Gly Lys Leu Arg Trp Glu Arg Thr Leu Gly Ala Ile 
                245                 250                 255     


Val Arg Gln Lys Asn His Pro Met Thr Pro Glu Ala Val Lys Ala Asn 
            260                 265                 270         


Trp Lys Lys Ile Cys Asp Phe Glu Asn Ala Ser Lys Pro Gln Ser Ile 
        275                 280                 285             


Gln Glu Ser Thr Gly Ser Ile Ile Glu Val Leu Ser Lys Ile Asp Ser 
    290                 295                 300                 


Glu Gly Gly Val Ser Ala Asn His Thr Ser Arg Ala Thr Ser Thr Ala 
305                 310                 315                 320 


Thr Ser Gly Phe Ala Gly Ala Ile Gly Gln Lys Leu Pro Pro Phe Ser 
                325                 330                 335     


Tyr Ala Tyr Thr Glu Leu Glu Ala Ile Met Tyr Ala Leu Gly Val Gly 
            340                 345                 350         


Ala Ser Ile Lys Asp Pro Lys Asp Leu Lys Phe Ile Tyr Glu Gly Ser 
        355                 360                 365             


Ser Asp Phe Ser Cys Leu Pro Thr Phe Gly Val Ile Ile Gly Gln Lys 
    370                 375                 380                 


Ser Met Met Gly Gly Gly Leu Ala Glu Ile Pro Gly Leu Ser Ile Asn 
385                 390                 395                 400 


Phe Ala Lys Val Leu His Gly Glu Gln Tyr Leu Glu Leu Tyr Lys Pro 
                405                 410                 415     


Leu Pro Arg Ala Gly Lys Leu Lys Cys Glu Ala Val Val Ala Asp Val 
            420                 425                 430         


Leu Asp Lys Gly Ser Gly Val Val Ile Ile Met Asp Val Tyr Ser Tyr 
        435                 440                 445             


Ser Glu Lys Glu Leu Ile Cys His Asn Gln Phe Ser Leu Phe Leu Val 
    450                 455                 460                 


Gly Ser Gly Gly Phe Gly Gly Lys Arg Thr Ser Asp Lys Val Lys Val 
465                 470                 475                 480 


Ala Val Ala Ile Pro Asn Arg Pro Pro Asp Ala Val Leu Thr Asp Thr 
                485                 490                 495     


Thr Ser Leu Asn Gln Ala Ala Leu Tyr Arg Leu Ser Gly Asp Trp Asn 
            500                 505                 510         


Pro Leu His Ile Asp Pro Asn Phe Ala Ser Leu Ala Gly Phe Asp Lys 
        515                 520                 525             


Pro Ile Leu His Gly Leu Cys Thr Phe Gly Phe Ser Ala Arg Arg Val 
    530                 535                 540                 


Leu Gln Gln Phe Ala Asp Asn Asp Val Ser Arg Phe Lys Ala Ile Lys 
545                 550                 555                 560 


Ala Arg Phe Ala Lys Pro Val Tyr Pro Gly Gln Thr Leu Gln Thr Glu 
                565                 570                 575     


Met Trp Lys Glu Gly Asn Arg Ile His Phe Gln Thr Lys Val Gln Glu 
            580                 585                 590         


Thr Gly Asp Ile Val Ile Ser Asn Ala Tyr Val Asp Leu Ala Pro Thr 
        595                 600                 605             


Ser Gly Thr Ser Ala Lys Thr Pro Ser Glu Gly Gly Lys Leu Gln Ser 
    610                 615                 620                 


Thr Phe Val Phe Glu Glu Ile Gly Arg Arg Leu Lys Asp Ile Gly Pro 
625                 630                 635                 640 


Glu Val Val Lys Lys Val Asn Ala Val Phe Glu Trp His Ile Thr Lys 
                645                 650                 655     


Gly Gly Asn Ile Gly Ala Lys Trp Thr Ile Asp Leu Lys Ser Gly Ser 
            660                 665                 670         


Gly Lys Val Tyr Gln Gly Pro Ala Lys Gly Ala Ala Asp Thr Thr Ile 
        675                 680                 685             


Ile Leu Ser Asp Glu Asp Phe Met Glu Val Val Leu Gly Lys Leu Asp 
    690                 695                 700                 


Pro Gln Lys Ala Phe Phe Ser Gly Arg Leu Lys Ala Arg Gly Asn Ile 
705                 710                 715                 720 


Met Leu Ser Gln Lys Leu Gln Met Ile Leu Lys Asp Tyr Ala Lys Leu 
                725                 730                 735     


<210>  46
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ala Pro Gln Arg Ala Gly Pro Gly Leu Gly Lys Pro Ser Ser Lys 
1               5                   10                  15      


Lys Ser Arg Ala Leu Arg Gly Gly Pro Gly Val Pro Arg Ala Arg Gln 
            20                  25                  30          


Arg Ser Pro Arg Ala Ala Ala Glu Leu Asn Thr Glu Val Pro Lys Pro 
        35                  40                  45              


Ser Ala Lys Asp Val Glu Ile Leu Glu Gln Glu Ser Glu Val Leu Glu 
    50                  55                  60                  


Pro Ser Val Glu Gln Asp Ala Glu Ser Pro Gly Leu Ser Thr Ala Ala 
65                  70                  75                  80  


Gly Phe Glu Ser Pro Glu Pro Gly Arg Asp Asp Pro Gly Pro Ser Glu 
                85                  90                  95      


Ala Gln Arg Ala Glu Val Gln Gly Gln His Pro Pro Pro Gly Pro Lys 
            100                 105                 110         


Thr Ser Ser Ser Arg Ser Gly Ser Glu Ala Pro His Leu Arg Phe Pro 
        115                 120                 125             


Pro Cys Pro Glu Ala Pro Gln Arg Pro Pro Glu Glu Arg Phe Met Glu 
    130                 135                 140                 


Thr Pro Ile Glu Arg Glu Ile Arg Arg Ser Cys Glu Arg Glu Glu Ser 
145                 150                 155                 160 


Leu Arg Arg Ser Arg Gly Leu Ser Pro Gly Arg Ala Gly Arg Glu Leu 
                165                 170                 175     


Val Glu Leu Arg Val Arg Pro Val Leu Asn Leu Pro Gly Pro Gly Pro 
            180                 185                 190         


Ala Leu Pro Arg Ala Leu Glu Arg Ala Arg Ala Gly Ala Gln Met Gln 
        195                 200                 205             


Arg Asp Ile Glu Arg Glu Ala His Arg Gln Ala Ala Leu Ala Arg Pro 
    210                 215                 220                 


Ala Val Pro Glu Pro Arg Ala Arg Ser Pro Pro Gln Pro Leu Gly Glu 
225                 230                 235                 240 


Leu Lys Arg Phe Phe Glu Ala Ala Ala Gly Ser Gly Ser Ser Ala Gly 
                245                 250                 255     


Ala Gly Asp Gly Ala Gly Pro Gln Arg Leu Pro Glu Pro Gly Gly Arg 
            260                 265                 270         


Pro Arg Ser Ala Val Gln Gly Gly Cys Arg Val Leu Gly Ser Ala Pro 
        275                 280                 285             


Pro Pro Phe Thr Pro Ser Leu Leu Glu Gln Glu Val Arg Ala Val Arg 
    290                 295                 300                 


Glu Arg Glu Gln Glu Leu Gln Arg Gln Arg Arg Ser Val Tyr Gly Thr 
305                 310                 315                 320 


Ala Glu Phe Lys Glu Pro Thr Pro Ser Leu Thr Ala Ser Arg Gly Asp 
                325                 330                 335     


Gly Lys Leu Val Val Ile Trp Pro Pro Arg Arg Lys Val Ser Glu Asn 
            340                 345                 350         


Gly Leu Glu Gln Glu Glu Arg Lys Pro 
        355                 360     


<210>  47
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  47

Ile Ser Ala Arg Gly Ala Pro Ala Pro Val Pro Gly Arg Ser Leu Gln 
1               5                   10                  15      


Ala Ala Arg Arg Pro Arg Pro Ser Leu Gly Ala Ala Arg Asp Arg Gly 
            20                  25                  30          


Trp Lys Gly Glu Ser Gly Lys Lys Glu Arg Lys Glu Lys Glu Arg Gly 
        35                  40                  45              


Arg Val Asn Leu Gly Glu Ser Ala Glu Gly Arg Ala Ala Ser Glu Cys 
    50                  55                  60                  


Pro Glu Arg Gly Gly Gly Gly Gly Glu Gly Glu Gly Glu Glu Glu Glu 
65                  70                  75                  80  


Glu Glu Glu Gly Ser Ala Pro Pro Pro Ser Pro Pro Thr Cys Arg Gly 
                85                  90                  95      


Ala Cys Gly Ala Trp Asp His Val Pro Ala Leu Ala Pro Gly Arg His 
            100                 105                 110         


Pro Ala Pro Pro Val Ala Ala Arg Ala Pro Gln Val Phe Val Cys Leu 
        115                 120                 125             


Arg Arg Val Gly Val Arg Leu Ala Leu Pro Ser Ala Pro Ser Cys Arg 
    130                 135                 140                 


Arg Ala Pro Gln Arg Gly Arg Glu Ala Gly Ala Gly Arg Val Tyr Leu 
145                 150                 155                 160 


Pro Ala Ala Lys Thr Phe Ile Met Gly Cys Thr Ser Glu Gly Leu Gly 
                165                 170                 175     


Gly Asn Leu Arg Cys Arg Gln Phe Ser Glu Val His Ala Gln Met Gly 
            180                 185                 190         


Asn Leu Pro Asp Leu Tyr Thr Gly Ala Cys Val Val Arg Gln Lys Gln 
        195                 200                 205             


Leu Tyr Leu Ala Gly Ile Pro Ser Pro Gly Ser Cys Leu Arg Cys Ile 
    210                 215                 220                 


Ile Gly Asn Tyr Glu Trp Lys Lys Val Arg Val Lys Gly Gly Asp Glu 
225                 230                 235                 240 


<210>  48
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
            100                 105                 110         


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
        115                 120                 125             


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
    130                 135                 140                 


Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
145                 150                 155                 160 


Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                165                 170                 175     


Pro Val Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
            180                 185                 190         


Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
        195                 200                 205             


Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Thr Thr 
    210                 215                 220                 


Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys 
225                 230                 235                 240 


Thr Ile Val Thr Tyr Gln Met Val Lys Thr Lys Glu Ala Gly Met Gln 
                245                 250                 255     


Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly 
            260                 265                 270         


Leu Glu Met Glu Leu Arg Leu Arg Glu Arg Leu Ala Gly Leu Phe Asn 
        275                 280                 285             


Glu Gln Arg Lys Gly Gln Arg Ala Lys Asp Val Arg Glu Asn Pro Arg 
    290                 295                 300                 


Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu 
305                 310                 315                 320 


Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp 
                325                 330                 335     


Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys 
            340                 345                 350         


Ala Asp Leu Phe Glu Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln 
        355                 360                 365             


Ser Ala Glu Met Ser Leu Asp Glu Ile Glu Gln Val Ile Leu Val Gly 
    370                 375                 380                 


Gly Ala Thr Arg Val Pro Arg Val Gln Glu Val Leu Leu Lys Ala Val 
385                 390                 395                 400 


Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala 
                405                 410                 415     


Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val 
            420                 425                 430         


Lys Pro Phe Val Val Arg Asp Ala Val Val Tyr Pro Ile Leu Val Glu 
        435                 440                 445             


Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Ile His Ser Leu Lys His 
    450                 455                 460                 


Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys 
465                 470                 475                 480 


Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn 
                485                 490                 495     


Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly 
            500                 505                 510         


Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Asp Ser Phe 
        515                 520                 525             


Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn 
    530                 535                 540                 


Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe 
545                 550                 555                 560 


Glu Thr Leu Val Glu Asp Ser Ala Glu Glu Glu Ser Thr Leu Thr Lys 
                565                 570                 575     


Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Thr Pro Asp 
            580                 585                 590         


Ala Lys Glu Asn Gly Thr Asp Thr Val Gln Glu Glu Glu Glu Ser Pro 
        595                 600                 605             


Ala Glu Gly Ser Lys Asp Glu Pro Gly Glu Gln Val Glu Leu Lys Glu 
    610                 615                 620                 


Glu Ala Glu Ala Pro Val Glu Asp Gly Ser Gln Pro Pro Pro Pro Glu 
625                 630                 635                 640 


Pro Lys Gly Asp Ala Thr Pro Glu Gly Glu Lys Ala Thr Glu Lys Glu 
                645                 650                 655     


Asn Gly Asp Lys Ser Glu Ala Gln Lys Pro Ser Glu Lys Ala Glu Ala 
            660                 665                 670         


Gly Pro Glu Gly Val Ala Pro Ala Pro Glu Gly Glu Lys Lys Gln Lys 
        675                 680                 685             


Pro Ala Arg Lys Arg Arg Met Val Glu Glu Ile Gly Val Glu Leu Val 
    690                 695                 700                 


Val Leu Asp Leu Pro Asp Leu Pro Glu Asp Lys Leu Ala Gln Ser Val 
705                 710                 715                 720 


Gln Lys Leu Gln Asp Leu Thr Leu Arg Asp Leu Glu Lys Gln Glu Arg 
                725                 730                 735     


Glu Lys Ala Ala Asn Ser Leu Glu Ala Phe Ile Phe Glu Thr Gln Asp 
            740                 745                 750         


Lys Leu Tyr Gln Pro Glu Tyr Gln Glu Val Ser Thr Glu Glu Gln Arg 
        755                 760                 765             


Glu Glu Ile Ser Gly Lys Leu Ser Ala Ala Ser Thr Trp Leu Glu Asp 
    770                 775                 780                 


Glu Gly Val Gly Ala Thr Thr Val Met Leu Lys Glu Lys Leu Ala Glu 
785                 790                 795                 800 


Leu Arg Lys Leu Cys Gln Gly Leu Phe Phe Arg Val Glu Glu Arg Lys 
                805                 810                 815     


Lys Trp Pro Glu Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn His Ser 
            820                 825                 830         


Ser Met Phe Leu Lys Gly Ala Arg Leu Ile Pro Glu Met Asp Gln Ile 
        835                 840                 845             


Phe Thr Glu Val Glu Met Thr Thr Leu Glu Lys Val Ile Asn Glu Thr 
    850                 855                 860                 


Trp Ala Trp Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu Pro Ala 
865                 870                 875                 880 


Thr Glu Lys Pro Val Leu Leu Ser Lys Asp Ile Glu Ala Lys Met Met 
                885                 890                 895     


Ala Leu Asp Arg Glu Val Gln Tyr Leu Leu Asn Lys Ala Lys Phe Thr 
            900                 905                 910         


Lys Pro Arg Pro Arg Pro Lys Asp Lys Asn Gly Thr Arg Ala Glu Pro 
        915                 920                 925             


Pro Leu Asn Ala Ser Ala Ser Asp Gln Gly Glu Lys Val Ile Pro Pro 
    930                 935                 940                 


Ala Gly Gln Thr Glu Asp Ala Glu Pro Ile Ser Glu Pro Glu Lys Val 
945                 950                 955                 960 


Glu Thr Gly Ser Glu Pro Gly Asp Thr Glu Pro Leu Glu Leu Gly Gly 
                965                 970                 975     


Pro Gly Ala Glu Pro Glu Gln Lys Glu Gln Ser Thr Gly Gln Lys Arg 
            980                 985                 990         


Pro Leu Lys Asn Asp Glu Leu 
        995                 


<210>  49
<211>  1250
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ala Arg Gly Asp Ala Gly Arg Gly Arg Gly Leu Leu Ala Leu Thr 
1               5                   10                  15      


Phe Cys Leu Leu Ala Ala Arg Gly Glu Leu Leu Leu Pro Gln Glu Thr 
            20                  25                  30          


Thr Val Glu Leu Ser Cys Gly Val Gly Pro Leu Gln Val Ile Leu Gly 
        35                  40                  45              


Pro Glu Gln Ala Ala Val Leu Asn Cys Ser Leu Gly Ala Ala Ala Ala 
    50                  55                  60                  


Gly Pro Pro Thr Arg Val Thr Trp Ser Lys Asp Gly Asp Thr Leu Leu 
65                  70                  75                  80  


Glu His Asp His Leu His Leu Leu Pro Asn Gly Ser Leu Trp Leu Ser 
                85                  90                  95      


Gln Pro Leu Ala Pro Asn Gly Ser Asp Glu Ser Val Pro Glu Ala Val 
            100                 105                 110         


Gly Val Ile Glu Gly Asn Tyr Ser Cys Leu Ala His Gly Pro Leu Gly 
        115                 120                 125             


Val Leu Ala Ser Gln Thr Ala Val Val Lys Leu Ala Thr Leu Ala Asp 
    130                 135                 140                 


Phe Ser Leu His Pro Glu Ser Gln Thr Val Glu Glu Asn Gly Thr Ala 
145                 150                 155                 160 


Arg Phe Glu Cys His Ile Glu Gly Leu Pro Ala Pro Ile Ile Thr Trp 
                165                 170                 175     


Glu Lys Asp Gln Val Thr Leu Pro Glu Glu Pro Arg Leu Ile Val Leu 
            180                 185                 190         


Pro Asn Gly Val Leu Gln Ile Leu Asp Val Gln Glu Ser Asp Ala Gly 
        195                 200                 205             


Pro Tyr Arg Cys Val Ala Thr Asn Ser Ala Arg Gln His Phe Ser Gln 
    210                 215                 220                 


Glu Ala Leu Leu Ser Val Ala His Arg Gly Ser Leu Ala Ser Thr Arg 
225                 230                 235                 240 


Gly Gln Asp Val Val Ile Val Ala Ala Pro Glu Asn Thr Thr Val Val 
                245                 250                 255     


Ser Gly Gln Ser Val Val Met Glu Cys Val Ala Ser Ala Asp Pro Thr 
            260                 265                 270         


Pro Phe Val Ser Trp Val Arg Gln Asp Gly Lys Pro Ile Ser Thr Asp 
        275                 280                 285             


Val Ile Val Leu Gly Arg Thr Asn Leu Leu Ile Ala Asn Ala Gln Pro 
    290                 295                 300                 


Trp His Ser Gly Val Tyr Val Cys Arg Ala Asn Lys Pro Arg Thr Arg 
305                 310                 315                 320 


Asp Phe Ala Thr Ala Ala Ala Glu Leu Arg Val Leu Ala Ala Pro Ala 
                325                 330                 335     


Ile Thr Gln Ala Pro Glu Ala Leu Ser Arg Thr Arg Ala Ser Thr Ala 
            340                 345                 350         


Arg Phe Val Cys Arg Ala Ser Gly Glu Pro Arg Pro Ala Leu Arg Trp 
        355                 360                 365             


Leu His Asn Gly Ala Pro Leu Arg Pro Asn Gly Arg Val Lys Val Gln 
    370                 375                 380                 


Gly Gly Gly Gly Ser Leu Val Ile Thr Gln Ile Gly Leu Gln Asp Ala 
385                 390                 395                 400 


Gly Tyr Tyr Gln Cys Val Ala Glu Asn Ser Ala Gly Met Ala Cys Ala 
                405                 410                 415     


Ala Ala Ser Leu Ala Val Val Val Arg Glu Gly Leu Pro Ser Ala Pro 
            420                 425                 430         


Thr Arg Val Thr Ala Thr Pro Leu Ser Ser Ser Ala Val Leu Val Ala 
        435                 440                 445             


Trp Glu Arg Pro Glu Met His Ser Glu Gln Ile Ile Gly Phe Ser Leu 
    450                 455                 460                 


His Tyr Gln Lys Ala Arg Gly Met Asp Asn Val Glu Tyr Gln Phe Ala 
465                 470                 475                 480 


Val Asn Asn Asp Thr Thr Glu Leu Gln Val Arg Asp Leu Glu Pro Asn 
                485                 490                 495     


Thr Asp Tyr Glu Phe Tyr Val Val Ala Tyr Ser Gln Leu Gly Ala Ser 
            500                 505                 510         


Arg Thr Ser Thr Pro Ala Leu Val His Thr Leu Asp Asp Val Pro Ser 
        515                 520                 525             


Ala Ala Pro Gln Leu Ser Leu Ser Ser Pro Asn Pro Ser Asp Ile Arg 
    530                 535                 540                 


Val Ala Trp Leu Pro Leu Pro Pro Ser Leu Ser Asn Gly Gln Val Val 
545                 550                 555                 560 


Lys Tyr Lys Ile Glu Tyr Gly Leu Gly Lys Glu Asp Gln Ile Phe Ser 
                565                 570                 575     


Thr Glu Val Arg Gly Asn Glu Thr Gln Leu Met Leu Asn Ser Leu Gln 
            580                 585                 590         


Pro Asn Lys Val Tyr Arg Val Arg Ile Ser Ala Gly Thr Ala Ala Gly 
        595                 600                 605             


Phe Gly Ala Pro Ser Gln Trp Met His His Arg Thr Pro Ser Met His 
    610                 615                 620                 


Asn Gln Ser His Val Pro Phe Ala Pro Ala Glu Leu Lys Val Gln Ala 
625                 630                 635                 640 


Lys Met Glu Ser Leu Val Val Ser Trp Gln Pro Pro Pro His Pro Thr 
                645                 650                 655     


Gln Ile Ser Gly Tyr Lys Leu Tyr Trp Arg Glu Val Gly Ala Glu Glu 
            660                 665                 670         


Glu Ala Asn Gly Asp Arg Leu Pro Gly Gly Arg Gly Asp Gln Ala Trp 
        675                 680                 685             


Asp Val Gly Pro Val Arg Leu Lys Lys Lys Val Lys Gln Tyr Glu Leu 
    690                 695                 700                 


Thr Gln Leu Val Pro Gly Arg Leu Tyr Glu Val Lys Leu Val Ala Phe 
705                 710                 715                 720 


Asn Lys His Glu Asp Gly Tyr Ala Ala Val Trp Lys Gly Lys Thr Glu 
                725                 730                 735     


Lys Ala Pro Ala Pro Asp Met Pro Ile Gln Arg Gly Pro Pro Leu Pro 
            740                 745                 750         


Pro Ala His Val His Ala Glu Ser Asn Ser Ser Thr Ser Ile Trp Leu 
        755                 760                 765             


Arg Trp Lys Lys Pro Asp Phe Thr Thr Val Lys Ile Val Asn Tyr Thr 
    770                 775                 780                 


Val Arg Phe Ser Pro Trp Gly Leu Arg Asn Ala Ser Leu Val Thr Tyr 
785                 790                 795                 800 


Tyr Thr Ser Ser Gly Glu Asp Ile Leu Ile Gly Gly Leu Lys Pro Phe 
                805                 810                 815     


Thr Lys Tyr Glu Phe Ala Val Gln Ser His Gly Val Asp Met Asp Gly 
            820                 825                 830         


Pro Phe Gly Ser Val Val Glu Arg Ser Thr Leu Pro Asp Arg Pro Ser 
        835                 840                 845             


Thr Pro Pro Ser Asp Leu Arg Leu Ser Pro Leu Thr Pro Ser Thr Val 
    850                 855                 860                 


Arg Leu His Trp Cys Pro Pro Thr Glu Pro Asn Gly Glu Ile Val Glu 
865                 870                 875                 880 


Tyr Leu Ile Leu Tyr Ser Ser Asn His Thr Gln Pro Glu His Gln Trp 
                885                 890                 895     


Thr Leu Leu Thr Thr Gln Gly Asn Ile Phe Ser Ala Glu Val His Gly 
            900                 905                 910         


Leu Glu Ser Asp Thr Arg Tyr Phe Phe Lys Met Gly Ala Arg Thr Glu 
        915                 920                 925             


Val Gly Pro Gly Pro Phe Ser Arg Leu Gln Asp Val Ile Thr Leu Gln 
    930                 935                 940                 


Glu Lys Leu Ser Asp Ser Leu Asp Met His Ser Val Thr Gly Ile Ile 
945                 950                 955                 960 


Val Gly Val Cys Leu Gly Leu Leu Cys Leu Leu Ala Cys Met Cys Ala 
                965                 970                 975     


Gly Leu Arg Arg Ser Pro His Arg Glu Ser Leu Pro Gly Leu Ser Ser 
            980                 985                 990         


Thr Ala Thr Pro Gly Asn Pro Ala  Leu Tyr Ser Arg Ala  Arg Leu Gly 
        995                 1000                 1005             


Pro Pro  Ser Pro Pro Ala Ala  His Glu Leu Glu Ser  Leu Val His 
    1010                 1015                 1020             


Pro His  Pro Gln Asp Trp Ser  Pro Pro Pro Ser Asp  Val Glu Asp 
    1025                 1030                 1035             


Arg Ala  Glu Val His Ser Leu  Met Gly Gly Gly Val  Ser Glu Gly 
    1040                 1045                 1050             


Arg Ser  His Ser Lys Arg Lys  Ile Ser Trp Ala Gln  Pro Ser Gly 
    1055                 1060                 1065             


Leu Ser  Trp Ala Gly Ser Trp  Ala Gly Cys Glu Leu  Pro Gln Ala 
    1070                 1075                 1080             


Gly Pro  Arg Pro Ala Leu Thr  Arg Ala Leu Leu Pro  Pro Ala Gly 
    1085                 1090                 1095             


Thr Gly  Gln Thr Leu Leu Leu  Gln Ala Leu Val Tyr  Asp Ala Ile 
    1100                 1105                 1110             


Lys Gly  Asn Gly Arg Lys Lys  Ser Pro Pro Ala Cys  Arg Asn Gln 
    1115                 1120                 1125             


Val Glu  Ala Glu Val Ile Val  His Ser Asp Phe Ser  Ala Ser Asn 
    1130                 1135                 1140             


Gly Asn  Pro Asp Leu His Leu  Gln Asp Leu Glu Pro  Glu Asp Pro 
    1145                 1150                 1155             


Leu Pro  Pro Glu Ala Pro Asp  Leu Ile Ser Gly Val  Gly Asp Pro 
    1160                 1165                 1170             


Gly Gln  Gly Ala Ala Trp Leu  Asp Arg Glu Leu Gly  Gly Cys Glu 
    1175                 1180                 1185             


Leu Ala  Ala Pro Gly Pro Asp  Arg Leu Thr Cys Leu  Pro Glu Ala 
    1190                 1195                 1200             


Ala Ser  Ala Ser Cys Ser Tyr  Pro Asp Leu Gln Pro  Gly Glu Val 
    1205                 1210                 1215             


Leu Glu  Glu Thr Pro Gly Asp  Ser Cys Gln Leu Lys  Ser Pro Cys 
    1220                 1225                 1230             


Pro Leu  Gly Ala Ser Pro Gly  Leu Pro Arg Ser Pro  Val Ser Ser 
    1235                 1240                 1245             


Ser Ala  
    1250 


<210>  50
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Arg Gly Asp Arg Gly Arg Gly Arg Gly Gly Arg Phe Gly Ser Arg 
1               5                   10                  15      


Gly Gly Pro Gly Gly Gly Phe Arg Pro Phe Val Pro His Ile Pro Phe 
            20                  25                  30          


Asp Phe Tyr Leu Cys Glu Met Ala Phe Pro Arg Val Lys Pro Ala Pro 
        35                  40                  45              


Asp Glu Thr Ser Phe Ser Glu Ala Leu Leu Lys Arg Asn Gln Asp Leu 
    50                  55                  60                  


Ala Pro Asn Ser Ala Glu Gln Ala Ser Ile Leu Ser Leu Val Thr Lys 
65                  70                  75                  80  


Ile Asn Asn Val Ile Asp Asn Leu Ile Val Ala Pro Gly Thr Phe Glu 
                85                  90                  95      


Val Gln Ile Glu Glu Val Arg Gln Val Gly Ser Tyr Lys Lys Gly Thr 
            100                 105                 110         


Met Thr Thr Gly His Asn Val Ala Asp Leu Val Val Ile Leu Lys Ile 
        115                 120                 125             


Leu Pro Thr Leu Glu Ala Val Ala Ala Leu Gly Asn Lys Val Val Glu 
    130                 135                 140                 


Ser Leu Arg Ala Gln Asp Pro Ser Glu Val Leu Thr Met Leu Thr Asn 
145                 150                 155                 160 


Glu Thr Gly Phe Glu Ile Ser Ser Ser Asp Ala Thr Val Lys Ile Leu 
                165                 170                 175     


Ile Thr Thr Val Pro Pro Asn Leu Arg Lys Leu Asp Pro Glu Leu His 
            180                 185                 190         


Leu Asp Ile Lys Val Leu Gln Ser Ala Leu Ala Ala Ile Arg His Ala 
        195                 200                 205             


Arg Trp Phe Glu Glu Asn Ala Ser Gln Ser Thr Val Lys Val Leu Ile 
    210                 215                 220                 


Arg Leu Leu Lys Asp Leu Arg Ile Arg Phe Pro Gly Phe Glu Pro Leu 
225                 230                 235                 240 


Thr Pro Trp Ile Leu Asp Leu Leu Gly His Tyr Ala Val Met Asn Asn 
                245                 250                 255     


Pro Thr Arg Gln Pro Leu Ala Leu Asn Val Ala Tyr Arg Arg Cys Leu 
            260                 265                 270         


Gln Ile Leu Ala Ala Gly Leu Phe Leu Pro Gly Ser Val Gly Ile Thr 
        275                 280                 285             


Asp Pro Cys Glu Ser Gly Asn Phe Arg Val His Thr Val Met Thr Leu 
    290                 295                 300                 


Glu Gln Gln Asp Met Val Cys Tyr Thr Ala Gln Thr Leu Val Arg Ile 
305                 310                 315                 320 


Leu Ser His Gly Gly Phe Arg Lys Ile Leu Gly Gln Glu Gly Asp Ala 
                325                 330                 335     


Ser Tyr Leu Ala Ser Glu Ile Ser Thr Trp Asp Gly Val Ile Val Thr 
            340                 345                 350         


Pro Ser Glu Lys Ala Tyr Glu Lys Pro Pro Glu Lys Lys Glu Gly Glu 
        355                 360                 365             


Glu Glu Glu Glu Asn Thr Glu Glu Pro Pro Gln Gly Glu Glu Glu Glu 
    370                 375                 380                 


Ser Met Glu Thr Gln Glu 
385                 390 


<210>  51
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Trp Cys Leu His Cys Asn Ser Glu Arg Thr Gln Ser Leu Leu Glu 
1               5                   10                  15      


Leu Glu Leu Asp Ser Gly Val Glu Gly Glu Ala Pro Ser Ser Glu Thr 
            20                  25                  30          


Gly Thr Ser Leu Asp Ser Pro Ser Ala Tyr Pro Gln Gly Pro Leu Val 
        35                  40                  45              


Pro Gly Ser Ser Leu Ser Pro Asp His Tyr Glu His Thr Ser Val Gly 
    50                  55                  60                  


Ala Tyr Gly Leu Tyr Ser Gly Pro Pro Gly Gln Gln Gln Arg Thr Arg 
65                  70                  75                  80  


Arg Pro Lys Leu Gln His Ser Thr Ser Ile Leu Arg Lys Gln Ala Glu 
                85                  90                  95      


Glu Glu Ala Ile Lys Arg Ser Arg Ser Leu Ser Glu Ser Tyr Glu Leu 
            100                 105                 110         


Ser Ser Asp Leu Gln Asp Lys Gln Val Glu Met Leu Glu Arg Lys Tyr 
        115                 120                 125             


Gly Gly Arg Leu Val Thr Arg His Ala Ala Arg Thr Ile Gln Thr Ala 
    130                 135                 140                 


Phe Arg Gln Tyr Gln Met Asn Lys Asn Phe Glu Arg Leu Arg Ser Ser 
145                 150                 155                 160 


Met Ser Glu Asn Arg Met Ser Arg Arg Ile Val Leu Ser Asn Met Arg 
                165                 170                 175     


Met Gln Phe Ser Phe Glu Gly Pro Glu Lys Val His Ser Ser Tyr Phe 
            180                 185                 190         


Glu Gly Lys Gln Val Ser Val Thr Asn Asp Gly Ser Gln Leu Gly Ala 
        195                 200                 205             


Leu Val Ser Pro Glu Cys Gly Asp Leu Ser Glu Pro Thr Thr Leu Lys 
    210                 215                 220                 


Ser Pro Ala Pro Ser Ser Asp Phe Ala Asp Ala Ile Thr Glu Leu Glu 
225                 230                 235                 240 


Asp Ala Phe Ser Arg Gln Val Lys Ser Leu Ala Glu Ser Ile Asp Asp 
                245                 250                 255     


Ala Leu Asn Cys Arg Ser Leu His Thr Glu Glu Ala Pro Ala Leu Asp 
            260                 265                 270         


Ala Ala Arg Ala Arg Asp Thr Glu Pro Gln Thr Ala Leu His Gly Met 
        275                 280                 285             


Asp His Arg Lys Leu Asp Glu Met Thr Ala Ser Tyr Ser Asp Val Thr 
    290                 295                 300                 


Leu Tyr Ile Asp Glu Glu Glu Leu Ser Pro Pro Leu Pro Leu Ser Gln 
305                 310                 315                 320 


Ala Gly Asp Arg Pro Ser Ser Thr Glu Ser Asp Leu Arg Leu Arg Ala 
                325                 330                 335     


Gly Gly Ala Ala Pro Asp Tyr Trp Ala Leu Ala His Lys Glu Asp Lys 
            340                 345                 350         


Ala Asp Thr Asp Thr Ser Cys Arg Ser Thr Pro Ser Leu Glu Arg Gln 
        355                 360                 365             


Glu Gln Arg Leu Arg Val Glu His Leu Pro Leu Leu Thr Ile Glu Pro 
    370                 375                 380                 


Pro Ser Asp Ser Ser Val Asp Leu Ser Asp Arg Ser Glu Arg Gly Ser 
385                 390                 395                 400 


Leu Lys Arg Gln Ser Ala Tyr Glu Arg Ser Leu Gly Gly Gln Gln Gly 
                405                 410                 415     


Ser Pro Lys His Gly Pro His Ser Gly Ala Pro Lys Ser Leu Pro Arg 
            420                 425                 430         


Glu Glu Pro Glu Leu Arg Pro Arg Pro Pro Arg Pro Leu Asp Ser His 
        435                 440                 445             


Leu Ala Ile Asn Gly Ser Ala Asn Arg Gln Ser Lys Ser Glu Ser Asp 
    450                 455                 460                 


Tyr Ser Asp Gly Asp Asn Asp Ser Ile Asn Ser Thr Ser Asn Ser Asn 
465                 470                 475                 480 


Asp Thr Ile Asn Cys Ser Ser Glu Ser Ser Ser Arg Asp Ser Leu Arg 
                485                 490                 495     


Glu Gln Thr Leu Ser Lys Gln Thr Tyr His Lys Glu Ala Arg Asn Ser 
            500                 505                 510         


Trp Asp Ser Pro Ala Phe Ser Asn Asp Val Ile Arg Lys Arg His Tyr 
        515                 520                 525             


Arg Ile Gly Leu Asn Leu Phe Asn Lys Lys Pro Glu Lys Gly Val Gln 
    530                 535                 540                 


Tyr Leu Ile Glu Arg Gly Phe Val Pro Asp Thr Pro Val Gly Val Ala 
545                 550                 555                 560 


His Phe Leu Leu Gln Arg Lys Gly Leu Ser Arg Gln Met Ile Gly Glu 
                565                 570                 575     


Phe Leu Gly Asn Arg Gln Lys Gln Phe Asn Arg Asp Val Leu Asp Cys 
            580                 585                 590         


Val Val Asp Glu Met Asp Phe Ser Thr Met Glu Leu Asp Glu Ala Leu 
        595                 600                 605             


Arg Lys Phe Gln Ala His Ile Arg Val Gln Gly Glu Ala Gln Lys Val 
    610                 615                 620                 


Glu Arg Leu Ile Glu Ala Phe Ser Gln Arg Tyr Cys Ile Cys Asn Pro 
625                 630                 635                 640 


Gly Val Val Arg Gln Phe Arg Asn Pro Asp Thr Ile Phe Ile Leu Ala 
                645                 650                 655     


Phe Ala Ile Ile Leu Leu Asn Thr Asp Met Tyr Ser Pro Asn Val Lys 
            660                 665                 670         


Pro Glu Arg Lys Met Lys Leu Glu Asp Phe Ile Lys Asn Leu Arg Gly 
        675                 680                 685             


Val Asp Asp Gly Glu Asp Ile Pro Arg Glu Met Leu Met Gly Ile Tyr 
    690                 695                 700                 


Glu Arg Ile Arg Lys Arg Glu Leu Lys Thr Asn Glu Asp His Val Ser 
705                 710                 715                 720 


Gln Val Gln Lys Val Glu Lys Leu Ile Val Gly Lys Lys Pro Ile Gly 
                725                 730                 735     


Ser Leu His Pro Gly Leu Gly Cys Val Leu Ser Leu Pro His Arg Arg 
            740                 745                 750         


Leu Val Cys Tyr Cys Arg Leu Phe Glu Val Pro Asp Pro Asn Lys Pro 
        755                 760                 765             


Gln Lys Leu Gly Leu His Gln Arg Glu Ile Phe Leu Phe Asn Asp Leu 
    770                 775                 780                 


Leu Val Val Thr Lys Ile Phe Gln Lys Lys Lys Asn Ser Val Thr Tyr 
785                 790                 795                 800 


Ser Phe Arg Gln Ser Phe Ser Leu Tyr Gly Met Gln Val Leu Leu Phe 
                805                 810                 815     


Glu Asn Gln Tyr Tyr Pro Asn Gly Ile Arg Leu Thr Ser Ser Val Pro 
            820                 825                 830         


Gly Ala Asp Ile Lys Val Leu Ile Asn Phe Asn Ala Pro Asn Pro Gln 
        835                 840                 845             


Asp Arg Lys Lys Phe Thr Asp Asp Leu Arg Glu Ser Ile Ala Glu Val 
    850                 855                 860                 


Gln Glu Met Glu Lys His Arg Ile Glu Ser Glu Leu Glu Lys Gln Lys 
865                 870                 875                 880 


Gly Val Val Arg Pro Ser Met Ser Gln Cys Ser Ser Leu Lys Lys Glu 
                885                 890                 895     


Ser Gly Asn Gly Thr Leu Ser Arg Ala Cys Leu Asp Asp Ser Tyr Ala 
            900                 905                 910         


Ser Gly Glu Gly Leu Lys Arg Ser Ala Leu Ser Ser Ser Leu Arg Asp 
        915                 920                 925             


Leu Ser Glu Ala Gly Lys Arg Gly Arg Arg Ser Ser Ala Gly Ser Leu 
    930                 935                 940                 


Glu Ser Asn Val Glu Phe Gln Pro Phe Glu Pro Leu Gln Pro Ser Val 
945                 950                 955                 960 


Leu Cys Ser 
            


<210>  52
<211>  1657
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ser Ala Ala Asp Glu Val Asp Gly Leu Gly Val Ala Arg Pro His 
1               5                   10                  15      


Tyr Gly Ser Val Leu Asp Asn Glu Arg Leu Thr Ala Glu Glu Met Asp 
            20                  25                  30          


Glu Arg Arg Arg Gln Asn Val Ala Tyr Glu Tyr Leu Cys His Leu Glu 
        35                  40                  45              


Glu Ala Lys Arg Trp Met Glu Ala Cys Leu Gly Glu Asp Leu Pro Pro 
    50                  55                  60                  


Thr Thr Glu Leu Glu Glu Gly Leu Arg Asn Gly Val Tyr Leu Ala Lys 
65                  70                  75                  80  


Leu Gly Asn Phe Phe Ser Pro Lys Val Val Ser Leu Lys Lys Ile Tyr 
                85                  90                  95      


Asp Arg Glu Gln Thr Arg Tyr Lys Ala Thr Gly Leu His Phe Arg His 
            100                 105                 110         


Thr Asp Asn Val Ile Gln Trp Leu Asn Ala Met Asp Glu Ile Gly Leu 
        115                 120                 125             


Pro Lys Ile Phe Tyr Pro Glu Thr Thr Asp Ile Tyr Asp Arg Lys Asn 
    130                 135                 140                 


Met Pro Arg Cys Ile Tyr Cys Ile His Ala Leu Ser Leu Tyr Leu Phe 
145                 150                 155                 160 


Lys Leu Gly Leu Ala Pro Gln Ile Gln Asp Leu Tyr Gly Lys Val Asp 
                165                 170                 175     


Phe Thr Glu Glu Glu Ile Asn Asn Met Lys Thr Glu Leu Glu Lys Tyr 
            180                 185                 190         


Gly Ile Gln Met Pro Ala Phe Ser Lys Ile Gly Gly Ile Leu Ala Asn 
        195                 200                 205             


Glu Leu Ser Val Asp Glu Ala Ala Leu His Ala Ala Val Ile Ala Ile 
    210                 215                 220                 


Asn Glu Ala Ile Asp Arg Arg Ile Pro Ala Asp Thr Phe Ala Ala Leu 
225                 230                 235                 240 


Lys Asn Pro Asn Ala Met Leu Val Asn Leu Glu Glu Pro Leu Ala Ser 
                245                 250                 255     


Thr Tyr Gln Asp Ile Leu Tyr Gln Ala Lys Gln Asp Lys Met Thr Asn 
            260                 265                 270         


Ala Lys Asn Arg Thr Glu Asn Ser Glu Arg Glu Arg Asp Val Tyr Glu 
        275                 280                 285             


Glu Leu Leu Thr Gln Ala Glu Ile Gln Gly Asn Ile Asn Lys Val Asn 
    290                 295                 300                 


Thr Phe Ser Ala Leu Ala Asn Ile Asp Leu Ala Leu Glu Gln Gly Asp 
305                 310                 315                 320 


Ala Leu Ala Leu Phe Arg Ala Leu Gln Ser Pro Ala Leu Gly Leu Arg 
                325                 330                 335     


Gly Leu Gln Gln Gln Asn Ser Asp Trp Tyr Leu Lys Gln Leu Leu Ser 
            340                 345                 350         


Asp Lys Gln Gln Lys Arg Gln Ser Gly Gln Thr Asp Pro Leu Gln Lys 
        355                 360                 365             


Glu Glu Leu Gln Ser Gly Val Asp Ala Ala Asn Ser Ala Ala Gln Gln 
    370                 375                 380                 


Tyr Gln Arg Arg Leu Ala Ala Val Ala Leu Ile Asn Ala Ala Ile Gln 
385                 390                 395                 400 


Lys Gly Val Ala Glu Lys Thr Val Leu Glu Leu Met Asn Pro Glu Ala 
                405                 410                 415     


Gln Leu Pro Gln Val Tyr Pro Phe Ala Ala Asp Leu Tyr Gln Lys Glu 
            420                 425                 430         


Leu Ala Thr Leu Gln Arg Gln Ser Pro Glu His Asn Leu Thr His Pro 
        435                 440                 445             


Glu Leu Ser Val Ala Val Glu Met Leu Ser Ser Val Ala Leu Ile Asn 
    450                 455                 460                 


Arg Ala Leu Glu Ser Gly Asp Val Asn Thr Val Trp Lys Gln Leu Ser 
465                 470                 475                 480 


Ser Ser Val Thr Gly Leu Thr Asn Ile Glu Glu Glu Asn Cys Gln Arg 
                485                 490                 495     


Tyr Leu Asp Glu Leu Met Lys Leu Lys Ala Gln Ala His Ala Glu Asn 
            500                 505                 510         


Asn Glu Phe Ile Thr Trp Asn Asp Ile Gln Ala Cys Val Asp His Val 
        515                 520                 525             


Asn Leu Val Val Gln Glu Glu His Glu Arg Ile Leu Ala Ile Gly Leu 
    530                 535                 540                 


Ile Asn Glu Ala Leu Asp Glu Gly Asp Ala Gln Lys Thr Leu Gln Ala 
545                 550                 555                 560 


Leu Gln Ile Pro Ala Ala Lys Leu Glu Gly Val Leu Ala Glu Val Ala 
                565                 570                 575     


Gln His Tyr Gln Asp Thr Leu Ile Arg Ala Lys Arg Glu Lys Ala Gln 
            580                 585                 590         


Glu Ile Gln Asp Glu Ser Ala Val Leu Trp Leu Asp Glu Ile Gln Gly 
        595                 600                 605             


Gly Ile Trp Gln Ser Asn Lys Asp Thr Gln Glu Ala Gln Lys Phe Ala 
    610                 615                 620                 


Leu Gly Ile Phe Ala Ile Asn Glu Ala Val Glu Ser Gly Asp Val Gly 
625                 630                 635                 640 


Lys Thr Leu Ser Ala Leu Arg Ser Pro Asp Val Gly Leu Tyr Gly Val 
                645                 650                 655     


Ile Pro Glu Cys Gly Glu Thr Tyr His Ser Asp Leu Ala Glu Ala Lys 
            660                 665                 670         


Lys Lys Lys Leu Ala Val Gly Asp Asn Asn Ser Lys Trp Val Lys His 
        675                 680                 685             


Trp Val Lys Gly Gly Tyr Tyr Tyr Tyr His Asn Leu Glu Thr Gln Glu 
    690                 695                 700                 


Gly Gly Trp Asp Glu Pro Pro Asn Phe Val Gln Asn Ser Met Gln Leu 
705                 710                 715                 720 


Ser Arg Glu Glu Ile Gln Ser Ser Ile Ser Gly Val Thr Ala Ala Tyr 
                725                 730                 735     


Asn Arg Glu Gln Leu Trp Leu Ala Asn Glu Gly Leu Ile Thr Arg Leu 
            740                 745                 750         


Gln Ala Arg Cys Arg Gly Tyr Leu Val Arg Gln Glu Phe Arg Ser Arg 
        755                 760                 765             


Met Asn Phe Leu Lys Lys Gln Ile Pro Ala Ile Thr Cys Ile Gln Ser 
    770                 775                 780                 


Gln Trp Arg Gly Tyr Lys Gln Lys Lys Ala Tyr Gln Asp Arg Leu Ala 
785                 790                 795                 800 


Tyr Leu Arg Ser His Lys Asp Glu Val Val Lys Ile Gln Ser Leu Ala 
                805                 810                 815     


Arg Met His Gln Ala Arg Lys Arg Tyr Arg Asp Arg Leu Gln Tyr Phe 
            820                 825                 830         


Arg Asp His Ile Asn Asp Ile Ile Lys Ile Gln Ala Phe Ile Arg Ala 
        835                 840                 845             


Asn Lys Ala Arg Asp Asp Tyr Lys Thr Leu Ile Asn Ala Glu Asp Pro 
    850                 855                 860                 


Pro Met Val Val Val Arg Lys Phe Val His Leu Leu Asp Gln Ser Asp 
865                 870                 875                 880 


Gln Asp Phe Gln Glu Glu Leu Asp Leu Met Lys Met Arg Glu Glu Val 
                885                 890                 895     


Ile Thr Leu Ile Arg Ser Asn Gln Gln Leu Glu Asn Asp Leu Asn Leu 
            900                 905                 910         


Met Asp Ile Lys Ile Gly Leu Leu Val Lys Asn Lys Ile Thr Leu Gln 
        915                 920                 925             


Asp Val Val Ser His Ser Lys Lys Leu Thr Lys Lys Asn Lys Glu Gln 
    930                 935                 940                 


Leu Ser Asp Met Met Met Ile Asn Lys Gln Lys Gly Gly Leu Lys Ala 
945                 950                 955                 960 


Leu Ser Lys Glu Lys Arg Glu Lys Leu Glu Ala Tyr Gln His Leu Phe 
                965                 970                 975     


Tyr Leu Leu Gln Thr Asn Pro Thr Tyr Leu Ala Lys Leu Ile Phe Gln 
            980                 985                 990         


Met Pro Gln Asn Lys Ser Thr Lys  Phe Met Asp Ser Val  Ile Phe Thr 
        995                 1000                 1005             


Leu Tyr  Asn Tyr Ala Ser Asn  Gln Arg Glu Glu Tyr  Leu Leu Leu 
    1010                 1015                 1020             


Arg Leu  Phe Lys Thr Ala Leu  Gln Glu Glu Ile Lys  Ser Lys Val 
    1025                 1030                 1035             


Asp Gln  Ile Gln Glu Ile Val  Thr Gly Asn Pro Thr  Val Ile Lys 
    1040                 1045                 1050             


Met Val  Val Ser Phe Asn Arg  Gly Ala Arg Gly Gln  Asn Ala Leu 
    1055                 1060                 1065             


Arg Gln  Ile Leu Ala Pro Val  Val Lys Glu Ile Met  Asp Asp Lys 
    1070                 1075                 1080             


Ser Leu  Asn Ile Lys Thr Asp  Pro Val Asp Ile Tyr  Lys Ser Trp 
    1085                 1090                 1095             


Val Asn  Gln Met Glu Ser Gln  Thr Gly Glu Ala Ser  Lys Leu Pro 
    1100                 1105                 1110             


Tyr Asp  Val Thr Pro Glu Gln  Ala Leu Ala His Glu  Glu Val Lys 
    1115                 1120                 1125             


Thr Arg  Leu Asp Ser Ser Ile  Arg Asn Met Arg Ala  Val Thr Asp 
    1130                 1135                 1140             


Lys Phe  Leu Ser Ala Ile Val  Ser Ser Val Asp Lys  Ile Pro Tyr 
    1145                 1150                 1155             


Gly Met  Arg Phe Ile Ala Lys  Val Leu Lys Asp Ser  Leu His Glu 
    1160                 1165                 1170             


Lys Phe  Pro Asp Ala Gly Glu  Asp Glu Leu Leu Lys  Ile Ile Gly 
    1175                 1180                 1185             


Asn Leu  Leu Tyr Tyr Arg Tyr  Met Asn Pro Ala Ile  Val Ala Pro 
    1190                 1195                 1200             


Asp Ala  Phe Asp Ile Ile Asp  Leu Ser Ala Gly Gly  Gln Leu Thr 
    1205                 1210                 1215             


Thr Asp  Gln Arg Arg Asn Leu  Gly Ser Ile Ala Lys  Met Leu Gln 
    1220                 1225                 1230             


His Ala  Ala Ser Asn Lys Met  Phe Leu Gly Asp Asn  Ala His Leu 
    1235                 1240                 1245             


Ser Ile  Ile Asn Glu Tyr Leu  Ser Gln Ser Tyr Gln  Lys Phe Arg 
    1250                 1255                 1260             


Arg Phe  Phe Gln Thr Ala Cys  Asp Val Pro Glu Leu  Gln Asp Lys 
    1265                 1270                 1275             


Phe Asn  Val Asp Glu Tyr Ser  Asp Leu Val Thr Leu  Thr Lys Pro 
    1280                 1285                 1290             


Val Ile  Tyr Ile Ser Ile Gly  Glu Ile Ile Asn Thr  His Thr Leu 
    1295                 1300                 1305             


Leu Leu  Asp His Gln Asp Ala  Ile Ala Pro Glu His  Asn Asp Pro 
    1310                 1315                 1320             


Ile His  Glu Leu Leu Asp Asp  Leu Gly Glu Val Pro  Thr Ile Glu 
    1325                 1330                 1335             


Ser Leu  Ile Gly Glu Ser Ser  Gly Asn Leu Asn Asp  Pro Asn Lys 
    1340                 1345                 1350             


Glu Ala  Leu Ala Lys Thr Glu  Val Ser Leu Thr Leu  Thr Asn Lys 
    1355                 1360                 1365             


Phe Asp  Val Pro Gly Asp Glu  Asn Ala Glu Met Asp  Ala Arg Thr 
    1370                 1375                 1380             


Ile Leu  Leu Asn Thr Lys Arg  Leu Ile Val Asp Val  Ile Arg Phe 
    1385                 1390                 1395             


Gln Pro  Gly Glu Thr Leu Thr  Glu Ile Leu Glu Thr  Pro Ala Thr 
    1400                 1405                 1410             


Ser Glu  Gln Glu Ala Glu His  Gln Arg Ala Met Gln  Arg Arg Ala 
    1415                 1420                 1425             


Ile Arg  Asp Ala Lys Thr Pro  Asp Lys Met Lys Lys  Ser Lys Ser 
    1430                 1435                 1440             


Val Lys  Glu Asp Ser Asn Leu  Thr Leu Gln Glu Lys  Lys Glu Lys 
    1445                 1450                 1455             


Ile Gln  Thr Gly Leu Lys Lys  Leu Thr Glu Leu Gly  Thr Val Asp 
    1460                 1465                 1470             


Pro Lys  Asn Lys Tyr Gln Glu  Leu Ile Asn Asp Ile  Ala Arg Asp 
    1475                 1480                 1485             


Ile Arg  Asn Gln Arg Arg Tyr  Arg Gln Arg Arg Lys  Ala Glu Leu 
    1490                 1495                 1500             


Val Lys  Leu Gln Gln Thr Tyr  Ala Ala Leu Asn Ser  Lys Ala Thr 
    1505                 1510                 1515             


Phe Tyr  Gly Glu Gln Val Asp  Tyr Tyr Lys Ser Tyr  Ile Lys Thr 
    1520                 1525                 1530             


Cys Leu  Asp Asn Leu Ala Ser  Lys Gly Lys Val Ser  Lys Lys Pro 
    1535                 1540                 1545             


Arg Glu  Met Lys Gly Lys Lys  Ser Lys Lys Ile Ser  Leu Lys Tyr 
    1550                 1555                 1560             


Thr Ala  Ala Arg Leu His Glu  Lys Gly Val Leu Leu  Glu Ile Glu 
    1565                 1570                 1575             


Asp Leu  Gln Val Asn Gln Phe  Lys Asn Val Ile Phe  Glu Ile Ser 
    1580                 1585                 1590             


Pro Thr  Glu Glu Val Gly Asp  Phe Glu Val Lys Ala  Lys Phe Met 
    1595                 1600                 1605             


Gly Val  Gln Met Glu Thr Phe  Met Leu His Tyr Gln  Asp Leu Leu 
    1610                 1615                 1620             


Gln Leu  Gln Tyr Glu Gly Val  Ala Val Met Lys Leu  Phe Asp Arg 
    1625                 1630                 1635             


Ala Lys  Val Asn Val Asn Leu  Leu Ile Phe Leu Leu  Asn Lys Lys 
    1640                 1645                 1650             


Phe Tyr  Gly Lys 
    1655         


<210>  53
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Glu Val Met Asn Leu Met Glu Gln Pro Ile Lys Val Thr Glu Trp 
1               5                   10                  15      


Gln Gln Thr Tyr Thr Tyr Asp Ser Gly Ile His Ser Gly Ala Asn Thr 
            20                  25                  30          


Cys Val Pro Ser Val Ser Ser Lys Gly Ile Met Glu Glu Asp Glu Ala 
        35                  40                  45              


Cys Gly Arg Gln Tyr Thr Leu Lys Lys Thr Thr Thr Tyr Thr Gln Gly 
    50                  55                  60                  


Val Pro Pro Ser Gln Gly Asp Leu Glu Tyr Gln Met Ser Thr Thr Ala 
65                  70                  75                  80  


Arg Ala Lys Arg Val Arg Glu Ala Met Cys Pro Gly Val Ser Gly Glu 
                85                  90                  95      


Asp Ser Ser Leu Leu Leu Ala Thr Gln Val Glu Gly Gln Ala Thr Asn 
            100                 105                 110         


Leu Gln Arg Leu Ala Glu Pro Ser Gln Leu Leu Lys Ser Ala Ile Val 
        115                 120                 125             


His Leu Ile Asn Tyr Gln Asp Asp Ala Glu Leu Ala Thr Arg Ala Leu 
    130                 135                 140                 


Pro Glu Leu Thr Lys Leu Leu Asn Asp Glu Asp Pro Val Val Val Thr 
145                 150                 155                 160 


Lys Ala Ala Met Ile Val Asn Gln Leu Ser Lys Lys Glu Ala Ser Arg 
                165                 170                 175     


Arg Ala Leu Met Gly Ser Pro Gln Leu Val Ala Ala Val Val Arg Thr 
            180                 185                 190         


Met Gln Asn Thr Ser Asp Leu Asp Thr Ala Arg Cys Thr Thr Ser Ile 
        195                 200                 205             


Leu His Asn Leu Ser His His Arg Glu Gly Leu Leu Ala Ile Phe Lys 
    210                 215                 220                 


Ser Gly Gly Ile Pro Ala Leu Val Arg Met Leu Ser Ser Pro Val Glu 
225                 230                 235                 240 


Ser Val Leu Phe Tyr Ala Ile Thr Thr Leu His Asn Leu Leu Leu Tyr 
                245                 250                 255     


Gln Glu Gly Ala Lys Met Ala Val Arg Leu Ala Asp Gly Leu Gln Lys 
            260                 265                 270         


Met Val Pro Leu Leu Asn Lys Asn Asn Pro Lys Phe Leu Ala Ile Thr 
        275                 280                 285             


Thr Asp Cys Leu Gln Leu Leu Ala Tyr Gly Asn Gln Glu Ser Lys Leu 
    290                 295                 300                 


Ile Ile Leu Ala Asn Gly Gly Pro Gln Ala Leu Val Gln Ile Met Arg 
305                 310                 315                 320 


Asn Tyr Ser Tyr Glu Lys Leu Leu Trp Thr Thr Ser Arg Val Leu Lys 
                325                 330                 335     


Val Leu Ser Val Cys Pro Ser Asn Lys Pro Ala Ile Val Glu Ala Gly 
            340                 345                 350         


Gly Met Gln Ala Leu Gly Lys His Leu Thr Ser Asn Ser Pro Arg Leu 
        355                 360                 365             


Val Gln Asn Cys Leu Trp Thr Leu Arg Asn Leu Ser Asp Val Ala Thr 
    370                 375                 380                 


Lys Gln Glu Gly Leu Glu Ser Val Leu Lys Ile Leu Val Asn Gln Leu 
385                 390                 395                 400 


Ser Val Asp Asp Val Asn Val Leu Thr Cys Ala Thr Gly Thr Leu Ser 
                405                 410                 415     


Asn Leu Thr Cys Asn Asn Ser Lys Asn Lys Thr Leu Val Thr Gln Asn 
            420                 425                 430         


Ser Gly Val Glu Ala Leu Ile His Ala Ile Leu Arg Ala Gly Asp Lys 
        435                 440                 445             


Asp Asp Ile Thr Glu Pro Ala Val Cys Ala Leu Arg His Leu Thr Ser 
    450                 455                 460                 


Arg His Pro Glu Ala Glu Met Ala Gln Asn Ser Val Arg Leu Asn Tyr 
465                 470                 475                 480 


Gly Ile Pro Ala Ile Val Lys Leu Leu Asn Gln Pro Asn Gln Trp Pro 
                485                 490                 495     


Leu Val Lys Ala Thr Ile Gly Leu Ile Arg Asn Leu Ala Leu Cys Pro 
            500                 505                 510         


Ala Asn His Ala Pro Leu Gln Glu Ala Ala Val Ile Pro Arg Leu Val 
        515                 520                 525             


Gln Leu Leu Val Lys Ala His Gln Asp Ala Gln Arg His Val Ala Ala 
    530                 535                 540                 


Gly Thr Gln Gln Pro Tyr Thr Asp Gly Val Arg Met Glu Glu Ile Val 
545                 550                 555                 560 


Glu Gly Cys Thr Gly Ala Leu His Ile Leu Ala Arg Asp Pro Met Asn 
                565                 570                 575     


Arg Met Glu Ile Phe Arg Leu Asn Thr Ile Pro Leu Phe Val Gln Leu 
            580                 585                 590         


Leu Tyr Ser Ser Val Glu Asn Ile Gln Arg Val Ala Ala Gly Val Leu 
        595                 600                 605             


Cys Glu Leu Ala Gln Asp Lys Glu Ala Ala Asp Ala Ile Asp Ala Glu 
    610                 615                 620                 


Gly Ala Ser Ala Pro Leu Met Glu Leu Leu His Ser Arg Asn Glu Gly 
625                 630                 635                 640 


Thr Ala Thr Tyr Ala Ala Ala Val Leu Phe Arg Ile Ser Glu Asp Lys 
                645                 650                 655     


Asn Pro Asp Tyr Arg Lys Arg Val Ser Val Glu Leu Thr Asn Ser Leu 
            660                 665                 670         


Phe Lys His Asp Pro Ala Ala Trp Glu Ala Ala Gln Ser Met Ile Pro 
        675                 680                 685             


Ile Asn Glu Pro Tyr Gly Asp Asp Met Asp Ala Thr Tyr Arg Pro Met 
    690                 695                 700                 


Tyr Ser Ser Asp Val Pro Leu Asp Pro Leu Glu Met His Met Asp Met 
705                 710                 715                 720 


Asp Gly Asp Tyr Pro Ile Asp Thr Tyr Ser Asp Gly Leu Arg Pro Pro 
                725                 730                 735     


Tyr Pro Thr Ala Asp His Met Leu Ala 
            740                 745 


<210>  54
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ser Ile His Phe Ser Ser Pro Val Phe Thr Ser Arg Ser Ala Ala 
1               5                   10                  15      


Phe Ser Gly Arg Gly Ala Gln Val Arg Leu Ser Ser Ala Arg Pro Gly 
            20                  25                  30          


Gly Leu Gly Ser Ser Ser Leu Tyr Gly Leu Gly Ala Ser Arg Pro Arg 
        35                  40                  45              


Val Ala Pro Leu Arg Leu Asp Ala Asp Pro Ser Leu Gln Arg Val Arg 
    50                  55                  60                  


Gln Glu Glu Ser Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser 
65                  70                  75                  80  


Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Leu Leu Glu 
                85                  90                  95      


Thr Lys Trp Thr Leu Leu Gln Glu Gln Lys Ser Ala Lys Ser Ser Arg 
            100                 105                 110         


Leu Pro Asp Ile Phe Glu Ala Gln Ile Ala Gly Leu Arg Gly Gln Leu 
        115                 120                 125             


Glu Ala Leu Gln Val Asp Gly Gly Arg Leu Glu Ala Glu Leu Arg Ser 
    130                 135                 140                 


Met Gln Asp Val Val Glu Asp Phe Lys Asn Arg Tyr Glu Asp Glu Ile 
145                 150                 155                 160 


Asn Arg Arg Thr Ala Ala Glu Asn Glu Phe Val Val Leu Lys Lys Asp 
                165                 170                 175     


Val Asp Ala Ala Tyr Met Ser Lys Val Glu Leu Glu Ala Lys Val Asp 
            180                 185                 190         


Ala Leu Asn Asp Glu Ile Asn Phe Leu Arg Thr Leu Asn Glu Thr Glu 
        195                 200                 205             


Leu Thr Glu Leu Gln Ser Gln Ile Ser Asp Thr Ser Val Val Leu Ser 
    210                 215                 220                 


Met Asn Asn Ser Arg Ser Leu Asp Leu Asp Gly Ile Ile Ala Glu Val 
225                 230                 235                 240 


Lys Ala Gln Tyr Glu Glu Met Ala Lys Cys Ser Arg Ala Glu Ala Glu 
                245                 250                 255     


Ala Trp Tyr Gln Thr Lys Phe Glu Thr Leu Gln Ala Gln Ala Gly Lys 
            260                 265                 270         


His Gly Asp Asp Leu Arg Asn Thr Arg Asn Glu Ile Ser Glu Met Asn 
        275                 280                 285             


Arg Ala Ile Gln Arg Leu Gln Ala Glu Ile Asp Asn Ile Lys Asn Gln 
    290                 295                 300                 


Arg Ala Lys Leu Glu Ala Ala Ile Ala Glu Ala Glu Glu Arg Gly Glu 
305                 310                 315                 320 


Leu Ala Leu Lys Asp Ala Arg Ala Lys Gln Glu Glu Leu Glu Ala Ala 
                325                 330                 335     


Leu Gln Arg Ala Lys Gln Asp Met Ala Arg Gln Leu Arg Glu Tyr Gln 
            340                 345                 350         


Glu Leu Met Ser Val Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr 
        355                 360                 365             


Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Leu Ala Gly Asp Gly Val 
    370                 375                 380                 


Gly Ala Val Asn Ile Ser Val Met Asn Ser Thr Gly Gly Ser Ser Ser 
385                 390                 395                 400 


Gly Gly Gly Ile Gly Leu Thr Leu Gly Gly Thr Met Gly Ser Asn Ala 
                405                 410                 415     


Leu Ser Phe Ser Ser Ser Ala Gly Pro Gly Leu Leu Lys Ala Tyr Ser 
            420                 425                 430         


Ile Arg Thr Ala Ser Ala Ser Arg Arg Ser Ala Arg Asp 
        435                 440                 445 


<210>  55
<211>  1435
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ala Gln Cys Val Gln Ser Val Gln Glu Leu Ile Pro Asp Ser Phe 
1               5                   10                  15      


Val Pro Cys Val Ala Ala Leu Cys Ser Asp Glu Ala Glu Arg Leu Thr 
            20                  25                  30          


Arg Leu Asn His Leu Ser Phe Ala Glu Leu Leu Lys Pro Phe Ser Arg 
        35                  40                  45              


Leu Thr Ser Glu Val His Met Arg Asp Pro Asn Asn Gln Leu His Val 
    50                  55                  60                  


Ile Lys Asn Leu Lys Ile Ala Val Ser Asn Ile Val Thr Gln Pro Pro 
65                  70                  75                  80  


Gln Pro Gly Ala Ile Arg Lys Leu Leu Asn Asp Val Val Ser Gly Ser 
                85                  90                  95      


Gln Pro Ala Glu Gly Leu Val Ala Asn Val Ile Thr Ala Gly Asp Tyr 
            100                 105                 110         


Asp Leu Asn Ile Ser Ala Thr Thr Pro Trp Phe Glu Ser Tyr Arg Glu 
        115                 120                 125             


Thr Phe Leu Gln Ser Met Pro Ala Leu Asp His Glu Phe Leu Asn His 
    130                 135                 140                 


Tyr Leu Ala Cys Met Leu Val Ala Ser Ser Ser Glu Ala Glu Pro Val 
145                 150                 155                 160 


Glu Gln Phe Ser Lys Leu Ser Gln Glu Gln His Arg Ile Gln His Asn 
                165                 170                 175     


Ser Asp Tyr Ser Tyr Pro Lys Trp Phe Ile Pro Asn Thr Leu Lys Tyr 
            180                 185                 190         


Tyr Val Leu Leu His Asp Val Ser Ala Gly Asp Glu Gln Arg Ala Glu 
        195                 200                 205             


Ser Ile Tyr Glu Glu Met Lys Gln Lys Tyr Gly Thr Gln Gly Cys Tyr 
    210                 215                 220                 


Leu Leu Lys Ile Asn Ser Arg Thr Ser Asn Arg Ala Ser Asp Glu Gln 
225                 230                 235                 240 


Ile Pro Asp Pro Trp Ser Gln Tyr Leu Gln Lys Asn Ser Ile Gln Asn 
                245                 250                 255     


Gln Glu Ser Tyr Glu Asp Gly Pro Cys Thr Ile Thr Ser Asn Lys Asn 
            260                 265                 270         


Ser Asp Asn Asn Leu Leu Ser Leu Asp Gly Leu Asp Asn Glu Val Lys 
        275                 280                 285             


Asp Gly Leu Pro Asn Asn Phe Arg Ala His Pro Leu Gln Leu Glu Gln 
    290                 295                 300                 


Ser Ser Asp Pro Ser Asn Ser Ile Asp Gly Pro Asp His Leu Arg Ser 
305                 310                 315                 320 


Ala Ser Ser Leu His Glu Thr Lys Lys Gly Asn Thr Gly Ile Ile His 
                325                 330                 335     


Gly Ala Cys Leu Thr Leu Thr Asp His Asp Arg Ile Arg Gln Phe Ile 
            340                 345                 350         


Gln Glu Phe Thr Phe Arg Gly Leu Leu Pro His Ile Glu Lys Thr Ile 
        355                 360                 365             


Arg Gln Leu Asn Asp Gln Leu Ile Ser Arg Lys Gly Leu Ser Arg Ser 
    370                 375                 380                 


Leu Phe Ser Ala Thr Lys Lys Trp Phe Ser Gly Ser Lys Val Pro Glu 
385                 390                 395                 400 


Lys Ser Ile Asn Asp Leu Lys Asn Thr Ser Gly Leu Leu Tyr Pro Pro 
                405                 410                 415     


Glu Ala Pro Glu Leu Gln Ile Arg Lys Met Ala Asp Leu Cys Phe Leu 
            420                 425                 430         


Val Gln His Tyr Asp Leu Ala Tyr Ser Cys Tyr His Thr Ala Lys Lys 
        435                 440                 445             


Asp Phe Leu Asn Asp Gln Ala Met Leu Tyr Ala Ala Gly Ala Leu Glu 
    450                 455                 460                 


Met Ala Ala Val Ser Ala Phe Leu Gln Pro Gly Ala Pro Arg Pro Tyr 
465                 470                 475                 480 


Pro Ala His Tyr Met Asp Thr Ala Ile Gln Thr Tyr Arg Asp Ile Cys 
                485                 490                 495     


Lys Asn Met Val Leu Ala Glu Arg Cys Val Leu Leu Ser Ala Glu Leu 
            500                 505                 510         


Leu Lys Ser Gln Ser Lys Tyr Ser Glu Ala Ala Ala Leu Leu Ile Arg 
        515                 520                 525             


Leu Thr Ser Glu Asp Ser Asp Leu Arg Ser Ala Leu Leu Leu Glu Gln 
    530                 535                 540                 


Ala Ala His Cys Phe Ile Asn Met Lys Ser Pro Met Val Arg Lys Tyr 
545                 550                 555                 560 


Ala Phe His Met Ile Leu Ala Gly His Arg Phe Ser Lys Ala Gly Gln 
                565                 570                 575     


Lys Lys His Ala Leu Arg Cys Tyr Cys Gln Ala Met Gln Val Tyr Lys 
            580                 585                 590         


Gly Lys Gly Trp Ser Leu Ala Glu Asp His Ile Asn Phe Thr Ile Gly 
        595                 600                 605             


Arg Gln Ser Tyr Thr Leu Arg Gln Leu Asp Asn Ala Val Ser Ala Phe 
    610                 615                 620                 


Arg His Ile Leu Ile Asn Glu Ser Lys Gln Ser Ala Ala Gln Gln Gly 
625                 630                 635                 640 


Ala Phe Leu Arg Glu Tyr Leu Tyr Val Tyr Lys Asn Val Ser Gln Leu 
                645                 650                 655     


Ser Pro Asp Gly Pro Leu Pro Gln Leu Pro Leu Pro Tyr Ile Asn Ser 
            660                 665                 670         


Ser Ala Thr Arg Val Phe Phe Gly His Asp Arg Arg Pro Ala Asp Gly 
        675                 680                 685             


Glu Lys Gln Ala Ala Thr His Val Ser Leu Asp Gln Glu Tyr Asp Ser 
    690                 695                 700                 


Glu Ser Ser Gln Gln Trp Arg Glu Leu Glu Glu Gln Val Val Ser Val 
705                 710                 715                 720 


Val Asn Lys Gly Val Ile Pro Ser Asn Phe His Pro Thr Gln Tyr Cys 
                725                 730                 735     


Leu Asn Ser Tyr Ser Asp Asn Ser Arg Phe Pro Leu Ala Val Val Glu 
            740                 745                 750         


Glu Pro Ile Thr Val Glu Val Ala Phe Arg Asn Pro Leu Lys Val Leu 
        755                 760                 765             


Leu Leu Leu Thr Asp Leu Ser Leu Leu Trp Lys Phe His Pro Lys Asp 
    770                 775                 780                 


Phe Ser Gly Lys Asp Asn Glu Glu Val Lys Gln Leu Val Thr Ser Glu 
785                 790                 795                 800 


Pro Glu Met Ile Gly Ala Glu Val Ile Ser Glu Phe Leu Ile Asn Gly 
                805                 810                 815     


Glu Glu Ser Lys Val Ala Arg Leu Lys Leu Phe Pro His His Ile Gly 
            820                 825                 830         


Glu Leu His Ile Leu Gly Val Val Tyr Asn Leu Gly Thr Ile Gln Gly 
        835                 840                 845             


Ser Met Thr Val Asp Gly Ile Gly Ala Leu Pro Gly Cys His Thr Gly 
    850                 855                 860                 


Lys Tyr Ser Leu Ser Met Ser Val Arg Gly Lys Gln Asp Leu Glu Ile 
865                 870                 875                 880 


Gln Gly Pro Arg Leu Asn Asn Thr Lys Glu Glu Lys Thr Ser Val Lys 
                885                 890                 895     


Tyr Gly Pro Asp Arg Arg Leu Asp Pro Ile Ile Thr Glu Glu Met Pro 
            900                 905                 910         


Leu Leu Glu Val Phe Phe Ile His Phe Pro Thr Gly Leu Leu Cys Gly 
        915                 920                 925             


Glu Ile Arg Lys Ala Tyr Val Glu Phe Val Asn Val Ser Lys Cys Pro 
    930                 935                 940                 


Leu Thr Gly Leu Lys Val Val Ser Lys Arg Pro Glu Phe Phe Thr Phe 
945                 950                 955                 960 


Gly Gly Asn Thr Ala Val Leu Thr Pro Leu Ser Pro Ser Ala Ser Glu 
                965                 970                 975     


Asn Cys Ser Ala Tyr Lys Thr Val Val Thr Asp Ala Thr Ser Val Cys 
            980                 985                 990         


Thr Ala Leu Ile Ser Ser Ala Ser  Ser Val Asp Phe Gly  Ile Gly Thr 
        995                 1000                 1005             


Gly Ser  Gln Pro Glu Val Ile  Pro Val Pro Leu Pro  Asp Thr Val 
    1010                 1015                 1020             


Leu Leu  Pro Gly Ala Ser Val  Gln Leu Pro Met Trp  Leu Arg Gly 
    1025                 1030                 1035             


Pro Asp  Glu Glu Gly Val His  Glu Ile Asn Phe Leu  Phe Tyr Tyr 
    1040                 1045                 1050             


Glu Ser  Val Lys Lys Gln Pro  Lys Ile Arg His Arg  Ile Leu Arg 
    1055                 1060                 1065             


His Thr  Ala Ile Ile Cys Thr  Ser Arg Ser Leu Asn  Val Arg Ala 
    1070                 1075                 1080             


Thr Val  Cys Arg Ser Asn Ser  Leu Glu Asn Glu Glu  Gly Arg Gly 
    1085                 1090                 1095             


Gly Asn  Met Leu Val Phe Val  Asp Val Glu Asn Thr  Asn Thr Ser 
    1100                 1105                 1110             


Glu Ala  Gly Val Lys Glu Phe  His Ile Val Gln Val  Ser Ser Ser 
    1115                 1120                 1125             


Ser Lys  His Trp Lys Leu Gln  Lys Ser Val Asn Leu  Ser Glu Asn 
    1130                 1135                 1140             


Lys Asp  Thr Lys Leu Ala Ser  Arg Glu Lys Gly Lys  Phe Cys Phe 
    1145                 1150                 1155             


Lys Ala  Ile Arg Cys Glu Lys  Glu Glu Ala Ala Thr  Gln Ser Ser 
    1160                 1165                 1170             


Glu Lys  Tyr Thr Phe Ala Asp  Ile Ile Phe Gly Asn  Glu Gln Ile 
    1175                 1180                 1185             


Ile Ser  Ser Ala Ser Pro Cys  Ala Asp Phe Phe Tyr  Arg Ser Leu 
    1190                 1195                 1200             


Ser Ser  Glu Leu Lys Lys Pro  Gln Ala His Leu Pro  Val His Thr 
    1205                 1210                 1215             


Glu Lys  Gln Ser Thr Glu Asp  Ala Val Arg Leu Ile  Gln Lys Cys 
    1220                 1225                 1230             


Ser Glu  Val Asp Leu Asn Ile  Val Ile Leu Trp Lys  Ala Tyr Val 
    1235                 1240                 1245             


Val Glu  Asp Ser Lys Gln Leu  Ile Leu Glu Gly Gln  His His Val 
    1250                 1255                 1260             


Ile Leu  Arg Thr Ile Gly Lys  Glu Ala Phe Ser Tyr  Pro Gln Lys 
    1265                 1270                 1275             


Gln Glu  Pro Pro Glu Met Glu  Leu Leu Lys Phe Phe  Arg Pro Glu 
    1280                 1285                 1290             


Asn Ile  Thr Val Ser Ser Arg  Pro Ser Val Glu Gln  Leu Ser Ser 
    1295                 1300                 1305             


Leu Ile  Lys Thr Ser Leu His  Tyr Pro Glu Ser Phe  Asn His Pro 
    1310                 1315                 1320             


Phe His  Gln Lys Ser Leu Cys  Leu Val Pro Val Thr  Leu Leu Leu 
    1325                 1330                 1335             


Ser Asn  Cys Ser Lys Ala Asp  Val Asp Val Ile Val  Asp Leu Arg 
    1340                 1345                 1350             


His Lys  Thr Thr Ser Pro Glu  Ala Leu Glu Ile His  Gly Ser Phe 
    1355                 1360                 1365             


Thr Trp  Leu Gly Gln Thr Gln  Tyr Lys Leu Gln Leu  Lys Ser Gln 
    1370                 1375                 1380             


Glu Ile  His Ser Leu Gln Leu  Lys Ala Cys Phe Val  His Thr Gly 
    1385                 1390                 1395             


Val Tyr  Asn Leu Gly Thr Pro  Arg Val Phe Ala Lys  Leu Ser Asp 
    1400                 1405                 1410             


Gln Val  Thr Val Phe Glu Thr  Ser Gln Gln Asn Ser  Met Pro Ala 
    1415                 1420                 1425             


Leu Ile  Ile Ile Ser Asn Val  
    1430                 1435 


<210>  56
<211>  1328
<212>  PRT
<213>  Homo sapiens

<400>  56

Leu His Ser Asn Pro Glu Pro Lys Thr Phe Thr Phe Asp His Val Ala 
1               5                   10                  15      


Asp Val Asp Thr Thr Gln Glu Ser Val Phe Ala Thr Val Ala Lys Ser 
            20                  25                  30          


Ile Val Glu Ser Cys Met Ser Gly Tyr Asn Gly Thr Ile Phe Ala Tyr 
        35                  40                  45              


Gly Gln Thr Gly Ser Gly Lys Thr Phe Thr Met Met Gly Pro Ser Glu 
    50                  55                  60                  


Ser Asp Asn Phe Ser His Asn Leu Arg Gly Val Ile Pro Arg Ser Phe 
65                  70                  75                  80  


Glu Tyr Leu Phe Ser Leu Ile Asp Arg Glu Lys Glu Lys Ala Gly Ala 
                85                  90                  95      


Gly Lys Ser Phe Leu Cys Lys Cys Ser Phe Ile Glu Ile Tyr Asn Glu 
            100                 105                 110         


Gln Ile Tyr Asp Leu Leu Asp Ser Ala Ser Ala Gly Leu Tyr Leu Arg 
        115                 120                 125             


Glu His Ile Lys Lys Gly Val Phe Val Val Gly Ala Val Glu Gln Val 
    130                 135                 140                 


Val Thr Ser Ala Ala Glu Ala Tyr Gln Val Leu Ser Gly Gly Trp Arg 
145                 150                 155                 160 


Asn Arg Arg Val Ala Ser Thr Ser Met Asn Arg Glu Ser Ser Arg Ser 
                165                 170                 175     


His Ala Val Phe Thr Ile Thr Ile Glu Ser Met Glu Lys Ser Asn Glu 
            180                 185                 190         


Ile Val Asn Ile Arg Thr Ser Leu Leu Asn Leu Val Asp Leu Ala Gly 
        195                 200                 205             


Ser Glu Arg Gln Lys Asp Thr His Ala Glu Gly Met Arg Leu Lys Glu 
    210                 215                 220                 


Ala Gly Asn Ile Asn Arg Ser Leu Ser Cys Leu Gly Gln Val Ile Thr 
225                 230                 235                 240 


Ala Leu Val Asp Val Gly Asn Gly Lys Gln Arg His Val Cys Tyr Arg 
                245                 250                 255     


Asp Ser Lys Leu Thr Phe Leu Leu Arg Asp Ser Leu Gly Gly Asn Ala 
            260                 265                 270         


Lys Thr Ala Ile Ile Ala Asn Val His Pro Gly Ser Arg Cys Phe Gly 
        275                 280                 285             


Glu Thr Leu Ser Thr Leu Asn Phe Ala Gln Arg Ala Lys Leu Ile Lys 
    290                 295                 300                 


Asn Lys Ala Val Val Asn Glu Asp Thr Gln Gly Asn Val Ser Gln Leu 
305                 310                 315                 320 


Gln Ala Glu Val Lys Arg Leu Lys Glu Gln Leu Ala Glu Leu Ala Ser 
                325                 330                 335     


Gly Gln Thr Pro Pro Glu Ser Phe Leu Thr Arg Asp Lys Lys Lys Thr 
            340                 345                 350         


Asn Tyr Met Glu Tyr Phe Gln Glu Ala Met Leu Phe Phe Lys Lys Ser 
        355                 360                 365             


Glu Gln Glu Lys Lys Ser Leu Ile Glu Lys Val Thr Gln Leu Glu Asp 
    370                 375                 380                 


Leu Thr Leu Lys Lys Glu Lys Phe Ile Gln Ser Asn Lys Met Ile Val 
385                 390                 395                 400 


Lys Phe Arg Glu Asp Gln Ile Ile Arg Leu Glu Lys Leu His Lys Glu 
                405                 410                 415     


Ser Arg Gly Gly Phe Leu Pro Glu Glu Gln Asp Arg Leu Leu Ser Glu 
            420                 425                 430         


Leu Arg Asn Glu Ile Gln Thr Leu Arg Glu Gln Ile Glu His His Pro 
        435                 440                 445             


Arg Val Ala Lys Tyr Ala Met Glu Asn His Ser Leu Arg Glu Glu Asn 
    450                 455                 460                 


Arg Arg Leu Arg Leu Leu Glu Pro Val Lys Arg Ala Gln Glu Met Asp 
465                 470                 475                 480 


Ala Gln Thr Ile Ala Lys Leu Glu Lys Ala Phe Ser Glu Ile Ser Gly 
                485                 490                 495     


Met Glu Lys Ser Asp Lys Asn Gln Gln Gly Phe Ser Pro Lys Ala Gln 
            500                 505                 510         


Lys Glu Pro Cys Leu Phe Ala Asn Thr Glu Lys Leu Lys Ala Gln Leu 
        515                 520                 525             


Leu Gln Ile Gln Thr Glu Leu Asn Asn Ser Lys Gln Glu Tyr Glu Glu 
    530                 535                 540                 


Phe Lys Glu Leu Thr Arg Lys Arg Gln Leu Glu Leu Glu Ser Glu Leu 
545                 550                 555                 560 


Gln Ser Leu Gln Lys Ala Asn Leu Asn Leu Glu Asn Leu Leu Glu Ala 
                565                 570                 575     


Thr Lys Ala Cys Lys Arg Gln Glu Val Ser Gln Leu Asn Lys Ile His 
            580                 585                 590         


Ala Glu Thr Leu Lys Ile Ile Thr Thr Pro Thr Lys Ala Tyr Gln Leu 
        595                 600                 605             


His Ser Arg Pro Val Pro Lys Leu Ser Pro Glu Met Gly Ser Phe Gly 
    610                 615                 620                 


Ser Leu Tyr Thr Gln Asn Ser Ser Ile Leu Asp Asn Asp Ile Leu Asn 
625                 630                 635                 640 


Glu Pro Val Pro Pro Glu Met Asn Glu Gln Ala Phe Glu Ala Ile Ser 
                645                 650                 655     


Glu Glu Leu Arg Thr Val Gln Glu Gln Met Ser Ala Leu Gln Ala Lys 
            660                 665                 670         


Leu Asp Glu Glu Glu His Lys Asn Leu Lys Leu Gln Gln His Val Asp 
        675                 680                 685             


Lys Leu Glu His His Ser Thr Gln Met Gln Glu Leu Phe Ser Ser Glu 
    690                 695                 700                 


Arg Ile Asp Trp Thr Lys Gln Gln Glu Glu Leu Leu Ser Gln Leu Asn 
705                 710                 715                 720 


Val Leu Glu Lys Gln Leu Gln Glu Thr Gln Thr Lys Asn Asp Phe Leu 
                725                 730                 735     


Lys Ser Glu Val His Asp Leu Arg Val Val Leu His Ser Ala Asp Lys 
            740                 745                 750         


Glu Leu Ser Ser Val Lys Leu Glu Tyr Ser Ser Phe Lys Thr Asn Gln 
        755                 760                 765             


Glu Lys Glu Phe Asn Lys Leu Ser Glu Arg His Met His Val Gln Leu 
    770                 775                 780                 


Gln Leu Asp Asn Leu Arg Leu Glu Asn Glu Lys Leu Leu Glu Ser Lys 
785                 790                 795                 800 


Ala Cys Leu Gln Asp Ser Tyr Asp Asn Leu Gln Glu Ile Met Lys Phe 
                805                 810                 815     


Glu Ile Asp Gln Leu Ser Arg Asn Leu Gln Asn Phe Lys Lys Glu Asn 
            820                 825                 830         


Glu Thr Leu Lys Ser Asp Leu Asn Asn Leu Met Glu Leu Leu Glu Ala 
        835                 840                 845             


Glu Lys Glu Arg Asn Asn Lys Leu Ser Leu Gln Phe Glu Glu Asp Lys 
    850                 855                 860                 


Glu Asn Ser Ser Lys Glu Ile Leu Lys Val Leu Glu Ala Val Arg Gln 
865                 870                 875                 880 


Glu Lys Gln Lys Glu Thr Ala Lys Cys Glu Gln Gln Met Ala Lys Val 
                885                 890                 895     


Gln Lys Leu Glu Glu Ser Leu Leu Ala Thr Glu Lys Val Ile Ser Ser 
            900                 905                 910         


Leu Glu Lys Ser Arg Asp Ser Asp Lys Lys Val Val Ala Asp Leu Met 
        915                 920                 925             


Asn Gln Ile Gln Glu Leu Arg Thr Ser Val Cys Glu Lys Thr Glu Thr 
    930                 935                 940                 


Ile Asp Thr Leu Lys Gln Glu Leu Lys Asp Ile Asn Cys Lys Tyr Asn 
945                 950                 955                 960 


Ser Ala Leu Val Asp Arg Glu Glu Ser Arg Val Leu Ile Lys Lys Gln 
                965                 970                 975     


Glu Val Asp Ile Leu Asp Leu Lys Glu Thr Leu Arg Leu Arg Ile Leu 
            980                 985                 990         


Ser Glu Asp Ile Glu Arg Asp Met  Leu Cys Glu Asp Leu  Ala His Ala 
        995                 1000                 1005             


Thr Glu  Gln Leu Asn Met Leu  Thr Glu Ala Ser Lys  Lys His Ser 
    1010                 1015                 1020             


Gly Leu  Leu Gln Ser Ala Gln  Glu Glu Leu Thr Lys  Lys Glu Ala 
    1025                 1030                 1035             


Leu Ile  Gln Glu Leu Gln His  Lys Leu Asn Gln Lys  Lys Glu Glu 
    1040                 1045                 1050             


Val Glu  Gln Lys Lys Asn Glu  Tyr Asn Phe Lys Met  Arg Gln Leu 
    1055                 1060                 1065             


Glu His  Val Met Asp Ser Ala  Ala Glu Asp Pro Gln  Ser Pro Lys 
    1070                 1075                 1080             


Thr Pro  Pro His Phe Gln Thr  His Leu Ala Lys Leu  Leu Glu Thr 
    1085                 1090                 1095             


Gln Glu  Gln Glu Ile Glu Asp  Gly Arg Ala Ser Lys  Thr Ser Leu 
    1100                 1105                 1110             


Glu His  Leu Val Thr Lys Leu  Asn Glu Asp Arg Glu  Val Lys Asn 
    1115                 1120                 1125             


Ala Glu  Ile Leu Arg Met Lys  Glu Gln Leu Arg Glu  Met Glu Asn 
    1130                 1135                 1140             


Leu Arg  Leu Glu Ser Gln Gln  Leu Ile Glu Lys Asn  Trp Leu Leu 
    1145                 1150                 1155             


Gln Gly  Gln Leu Asp Asp Ile  Lys Arg Gln Lys Glu  Asn Ser Asp 
    1160                 1165                 1170             


Gln Asn  His Pro Asp Asn Gln  Gln Leu Lys Asn Glu  Gln Glu Glu 
    1175                 1180                 1185             


Ser Ile  Lys Glu Arg Leu Ala  Lys Ser Lys Ile Val  Glu Glu Met 
    1190                 1195                 1200             


Leu Lys  Met Lys Ala Asp Leu  Glu Glu Val Gln Ser  Ala Leu Tyr 
    1205                 1210                 1215             


Asn Lys  Glu Met Glu Cys Leu  Arg Met Thr Asp Glu  Val Glu Arg 
    1220                 1225                 1230             


Thr Gln  Thr Leu Glu Ser Lys  Ala Phe Gln Glu Lys  Glu Gln Leu 
    1235                 1240                 1245             


Arg Ser  Lys Leu Glu Glu Met  Tyr Glu Glu Arg Glu  Arg Thr Ser 
    1250                 1255                 1260             


Gln Glu  Met Glu Met Leu Arg  Lys Gln Val Glu Cys  Leu Ala Glu 
    1265                 1270                 1275             


Glu Asn  Gly Lys Leu Val Gly  His Gln Asn Leu His  Gln Lys Ile 
    1280                 1285                 1290             


Gln Tyr  Val Val Arg Leu Lys  Lys Glu Asn Val Arg  Leu Ala Glu 
    1295                 1300                 1305             


Glu Thr  Glu Lys Leu Arg Ala  Glu Asn Val Phe Leu  Lys Glu Lys 
    1310                 1315                 1320             


Lys Arg  Ser Glu Ser 
    1325             


<210>  57
<211>  600
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Thr Pro Leu Pro Gly Arg Ala Gly Gly Pro Ala Thr Pro Leu 
1               5                   10                  15      


Ser Pro Thr Arg Leu Ser Arg Leu Gln Glu Lys Glu Glu Leu Arg Glu 
            20                  25                  30          


Leu Asn Asp Arg Leu Ala His Tyr Ile Asp Arg Val Arg Ala Leu Glu 
        35                  40                  45              


Leu Glu Asn Asp Arg Leu Leu Leu Lys Ile Ser Glu Lys Glu Glu Val 
    50                  55                  60                  


Thr Thr Arg Glu Val Ser Gly Ile Lys Ala Leu Tyr Glu Ser Glu Leu 
65                  70                  75                  80  


Ala Asp Ala Arg Arg Val Leu Asp Glu Thr Ala Arg Glu Arg Ala Arg 
                85                  90                  95      


Leu Gln Ile Glu Ile Gly Lys Leu Arg Ala Glu Leu Asp Glu Val Asn 
            100                 105                 110         


Lys Ser Ala Lys Lys Arg Glu Gly Glu Leu Thr Val Ala Gln Gly Arg 
        115                 120                 125             


Val Lys Asp Leu Glu Ser Leu Phe His Arg Ser Glu Val Glu Leu Ala 
    130                 135                 140                 


Ala Ala Leu Ser Asp Lys Arg Gly Leu Glu Ser Asp Val Ala Glu Leu 
145                 150                 155                 160 


Arg Ala Gln Leu Ala Lys Ala Glu Asp Gly His Ala Val Ala Lys Lys 
                165                 170                 175     


Gln Leu Glu Lys Glu Thr Leu Met Arg Val Asp Leu Glu Asn Arg Cys 
            180                 185                 190         


Gln Ser Leu Gln Glu Glu Leu Asp Phe Arg Lys Ser Val Phe Glu Glu 
        195                 200                 205             


Glu Val Arg Glu Thr Arg Arg Arg His Glu Arg Arg Leu Val Glu Val 
    210                 215                 220                 


Asp Ser Ser Arg Gln Gln Glu Tyr Asp Phe Lys Met Ala Gln Ala Leu 
225                 230                 235                 240 


Glu Glu Leu Arg Ser Gln His Asp Glu Gln Val Arg Leu Tyr Lys Leu 
                245                 250                 255     


Glu Leu Glu Gln Thr Tyr Gln Ala Lys Leu Asp Ser Ala Lys Leu Ser 
            260                 265                 270         


Ser Asp Gln Asn Asp Lys Ala Ala Ser Ala Ala Arg Glu Glu Leu Lys 
        275                 280                 285             


Glu Ala Arg Met Arg Leu Glu Ser Leu Ser Tyr Gln Leu Ser Gly Leu 
    290                 295                 300                 


Gln Lys Gln Ala Ser Ala Ala Glu Asp Arg Ile Arg Glu Leu Glu Glu 
305                 310                 315                 320 


Ala Met Ala Gly Glu Arg Asp Lys Phe Arg Lys Met Leu Asp Ala Lys 
                325                 330                 335     


Glu Gln Glu Met Thr Glu Met Arg Asp Val Met Gln Gln Gln Leu Ala 
            340                 345                 350         


Glu Tyr Gln Glu Leu Leu Asp Val Lys Leu Ala Leu Asp Met Glu Ile 
        355                 360                 365             


Asn Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu Glu Arg Leu Lys Leu 
    370                 375                 380                 


Ser Pro Ser Pro Ser Ser Arg Val Thr Val Ser Arg Ala Thr Ser Ser 
385                 390                 395                 400 


Ser Ser Gly Ser Leu Ser Ala Thr Gly Arg Leu Gly Arg Ser Lys Arg 
                405                 410                 415     


Lys Arg Leu Glu Val Glu Glu Pro Leu Gly Ser Gly Pro Ser Val Leu 
            420                 425                 430         


Gly Thr Gly Thr Gly Gly Ser Gly Gly Phe His Leu Ala Gln Gln Ala 
        435                 440                 445             


Ser Ala Ser Gly Ser Val Ser Ile Glu Glu Ile Asp Leu Glu Gly Lys 
    450                 455                 460                 


Phe Val Gln Leu Lys Asn Asn Ser Asp Lys Asp Gln Ser Leu Gly Asn 
465                 470                 475                 480 


Trp Arg Ile Lys Arg Gln Val Leu Glu Gly Glu Glu Ile Ala Tyr Lys 
                485                 490                 495     


Phe Thr Pro Lys Tyr Ile Leu Arg Ala Gly Gln Met Val Thr Val Trp 
            500                 505                 510         


Ala Ala Gly Ala Gly Val Ala His Ser Pro Pro Ser Thr Leu Val Trp 
        515                 520                 525             


Lys Gly Gln Ser Ser Trp Gly Thr Gly Glu Ser Phe Arg Thr Val Leu 
    530                 535                 540                 


Val Asn Ala Asp Gly Glu Glu Val Ala Met Arg Thr Val Lys Lys Ser 
545                 550                 555                 560 


Ser Val Met Arg Glu Asn Glu Asn Gly Glu Glu Glu Glu Glu Glu Ala 
                565                 570                 575     


Glu Phe Gly Glu Glu Asp Leu Phe His Gln Gln Gly Asp Pro Arg Thr 
            580                 585                 590         


Thr Ser Arg Gly Cys Tyr Val Met 
        595                 600 


<210>  58
<211>  1761
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Gln Phe Gln Leu Thr Leu Phe Leu His Leu Gly Trp Leu Ser Tyr 
1               5                   10                  15      


Ser Lys Ala Gln Asp Asp Cys Asn Arg Gly Ala Cys His Pro Thr Thr 
            20                  25                  30          


Gly Asp Leu Leu Val Gly Arg Asn Thr Gln Leu Met Ala Ser Ser Thr 
        35                  40                  45              


Cys Gly Leu Ser Arg Ala Gln Lys Tyr Cys Ile Leu Ser Tyr Leu Glu 
    50                  55                  60                  


Gly Glu Gln Lys Cys Phe Ile Cys Asp Ser Arg Phe Pro Tyr Asp Pro 
65                  70                  75                  80  


Tyr Asp Gln Pro Asn Ser His Thr Ile Glu Asn Val Ile Val Ser Phe 
                85                  90                  95      


Glu Pro Asp Arg Glu Lys Lys Trp Trp Gln Ser Glu Asn Gly Leu Asp 
            100                 105                 110         


His Val Ser Ile Arg Leu Asp Leu Glu Ala Leu Phe Arg Phe Ser His 
        115                 120                 125             


Leu Ile Leu Thr Phe Lys Thr Phe Arg Pro Ala Ala Met Leu Val Glu 
    130                 135                 140                 


Arg Ser Thr Asp Tyr Gly His Asn Trp Lys Val Phe Lys Tyr Phe Ala 
145                 150                 155                 160 


Lys Asp Cys Ala Thr Ser Phe Pro Asn Ile Thr Ser Gly Gln Ala Gln 
                165                 170                 175     


Gly Val Gly Asp Ile Val Cys Asp Ser Lys Tyr Ser Asp Ile Glu Pro 
            180                 185                 190         


Ser Thr Gly Gly Glu Val Val Leu Lys Val Leu Asp Pro Ser Phe Glu 
        195                 200                 205             


Ile Glu Asn Pro Tyr Ser Pro Tyr Ile Gln Asp Leu Val Thr Leu Thr 
    210                 215                 220                 


Asn Leu Arg Ile Asn Phe Thr Lys Leu His Thr Leu Gly Asp Ala Leu 
225                 230                 235                 240 


Leu Gly Arg Arg Gln Asn Asp Ser Leu Asp Lys Tyr Tyr Tyr Ala Leu 
                245                 250                 255     


Tyr Glu Met Ile Val Arg Gly Ser Cys Phe Cys Asn Gly His Ala Ser 
            260                 265                 270         


Glu Cys Arg Pro Met Gln Lys Met Arg Gly Asp Val Phe Ser Pro Pro 
        275                 280                 285             


Gly Met Val His Gly Gln Cys Val Cys Gln His Asn Thr Asp Gly Pro 
    290                 295                 300                 


Asn Cys Glu Arg Cys Lys Asp Phe Phe Gln Asp Ala Pro Trp Arg Pro 
305                 310                 315                 320 


Ala Ala Asp Leu Gln Asp Asn Ala Cys Arg Ser Cys Ser Cys Asn Ser 
                325                 330                 335     


His Ser Ser Arg Cys His Phe Asp Met Thr Thr Tyr Leu Ala Ser Gly 
            340                 345                 350         


Gly Leu Ser Gly Gly Val Cys Glu Asp Cys Gln His Asn Thr Glu Gly 
        355                 360                 365             


Gln His Cys Asp Arg Cys Arg Pro Leu Phe Tyr Arg Asp Pro Leu Lys 
    370                 375                 380                 


Thr Ile Ser Asp Pro Tyr Ala Cys Ile Pro Cys Glu Cys Asp Pro Asp 
385                 390                 395                 400 


Gly Thr Ile Ser Gly Gly Ile Cys Val Ser His Ser Asp Pro Ala Leu 
                405                 410                 415     


Gly Ser Val Ala Gly Gln Cys Leu Cys Lys Glu Asn Val Glu Gly Ala 
            420                 425                 430         


Lys Cys Asp Gln Cys Lys Pro Asn His Tyr Gly Leu Ser Ala Thr Asp 
        435                 440                 445             


Pro Leu Gly Cys Gln Pro Cys Asp Cys Asn Pro Leu Gly Ser Leu Pro 
    450                 455                 460                 


Phe Leu Thr Cys Asp Val Asp Thr Gly Gln Cys Leu Cys Leu Ser Tyr 
465                 470                 475                 480 


Val Thr Gly Ala His Cys Glu Glu Cys Thr Val Gly Tyr Trp Gly Leu 
                485                 490                 495     


Gly Asn His Leu His Gly Cys Ser Pro Cys Asp Cys Asp Ile Gly Gly 
            500                 505                 510         


Ala Tyr Ser Asn Val Cys Ser Pro Lys Asn Gly Gln Cys Glu Cys Arg 
        515                 520                 525             


Pro His Val Thr Gly Arg Ser Cys Ser Glu Pro Ala Pro Gly Tyr Phe 
    530                 535                 540                 


Phe Ala Pro Leu Asn Phe Tyr Leu Tyr Glu Ala Glu Glu Ala Thr Thr 
545                 550                 555                 560 


Leu Gln Gly Leu Ala Pro Leu Gly Ser Glu Thr Phe Gly Gln Ser Pro 
                565                 570                 575     


Ala Val His Val Val Leu Gly Glu Pro Val Pro Gly Asn Pro Val Thr 
            580                 585                 590         


Trp Thr Gly Pro Gly Phe Ala Arg Val Leu Pro Gly Ala Gly Leu Arg 
        595                 600                 605             


Phe Ala Val Asn Asn Ile Pro Phe Pro Val Asp Phe Thr Ile Ala Ile 
    610                 615                 620                 


His Tyr Glu Thr Gln Ser Ala Ala Asp Trp Thr Val Gln Ile Val Val 
625                 630                 635                 640 


Asn Pro Pro Gly Gly Ser Glu His Cys Ile Pro Lys Thr Leu Gln Ser 
                645                 650                 655     


Lys Pro Gln Ser Phe Ala Leu Pro Ala Ala Thr Arg Ile Met Leu Leu 
            660                 665                 670         


Pro Thr Pro Ile Cys Leu Glu Pro Asp Val Gln Tyr Ser Ile Asp Val 
        675                 680                 685             


Tyr Phe Ser Gln Pro Leu Gln Gly Glu Ser His Ala His Ser His Val 
    690                 695                 700                 


Leu Val Asp Ser Leu Gly Leu Ile Pro Gln Ile Asn Ser Leu Glu Asn 
705                 710                 715                 720 


Phe Cys Ser Lys Gln Asp Leu Asp Glu Tyr Gln Leu His Asn Cys Val 
                725                 730                 735     


Glu Ile Ala Ser Ala Met Gly Pro Gln Val Leu Pro Gly Ala Cys Glu 
            740                 745                 750         


Arg Leu Ile Ile Ser Met Ser Ala Lys Leu His Asp Gly Ala Val Ala 
        755                 760                 765             


Cys Lys Cys His Pro Gln Gly Ser Val Gly Ser Ser Cys Ser Arg Leu 
    770                 775                 780                 


Gly Gly Gln Cys Gln Cys Lys Pro Leu Val Val Gly Arg Cys Cys Asp 
785                 790                 795                 800 


Arg Cys Ser Thr Gly Ser Tyr Asp Leu Gly His His Gly Cys His Pro 
                805                 810                 815     


Cys His Cys His Pro Gln Gly Ser Lys Asp Thr Val Cys Asp Gln Val 
            820                 825                 830         


Thr Gly Gln Cys Pro Cys His Gly Glu Val Ser Gly Arg Arg Cys Asp 
        835                 840                 845             


Arg Cys Leu Ala Gly Tyr Phe Gly Phe Pro Ser Cys His Pro Cys Pro 
    850                 855                 860                 


Cys Asn Arg Phe Ala Glu Leu Cys Asp Pro Glu Thr Gly Ser Cys Phe 
865                 870                 875                 880 


Asn Cys Gly Gly Phe Thr Thr Gly Arg Asn Cys Glu Arg Cys Ile Asp 
                885                 890                 895     


Gly Tyr Tyr Gly Asn Pro Ser Ser Gly Gln Pro Cys Arg Pro Cys Leu 
            900                 905                 910         


Cys Pro Asp Asp Pro Ser Ser Asn Gln Tyr Phe Ala His Ser Cys Tyr 
        915                 920                 925             


Gln Asn Leu Trp Ser Ser Asp Val Ile Cys Asn Cys Leu Gln Gly Tyr 
    930                 935                 940                 


Thr Gly Thr Gln Cys Gly Glu Cys Ser Thr Gly Phe Tyr Gly Asn Pro 
945                 950                 955                 960 


Arg Ile Ser Gly Ala Pro Cys Gln Pro Cys Ala Cys Asn Asn Asn Ile 
                965                 970                 975     


Asp Val Thr Asp Pro Glu Ser Cys Ser Arg Val Thr Gly Glu Cys Leu 
            980                 985                 990         


Arg Cys Leu His Asn Thr Gln Gly  Ala Asn Cys Gln Leu  Cys Lys Pro 
        995                 1000                 1005             


Gly His  Tyr Gly Ser Ala Leu  Asn Gln Thr Cys Arg  Arg Cys Ser 
    1010                 1015                 1020             


Cys His  Ala Ser Gly Val Ser  Pro Met Glu Cys Pro  Pro Gly Gly 
    1025                 1030                 1035             


Gly Ala  Cys Leu Cys Asp Pro  Val Thr Gly Ala Cys  Pro Cys Leu 
    1040                 1045                 1050             


Pro Asn  Val Thr Gly Leu Ala  Cys Asp Arg Cys Ala  Asp Gly Tyr 
    1055                 1060                 1065             


Trp Asn  Leu Val Pro Gly Arg  Gly Cys Gln Ser Cys  Asp Cys Asp 
    1070                 1075                 1080             


Pro Arg  Thr Ser Gln Ser Ser  His Cys Asp Gln Leu  Thr Gly Gln 
    1085                 1090                 1095             


Cys Pro  Cys Lys Leu Gly Tyr  Gly Gly Lys Arg Cys  Ser Glu Cys 
    1100                 1105                 1110             


Gln Glu  Asn Tyr Tyr Gly Asp  Pro Pro Gly Arg Cys  Ile Pro Cys 
    1115                 1120                 1125             


Asp Cys  Asn Arg Ala Gly Thr  Gln Lys Pro Ile Cys  Asp Pro Asp 
    1130                 1135                 1140             


Thr Gly  Met Cys Arg Cys Arg  Glu Gly Val Ser Gly  Gln Arg Cys 
    1145                 1150                 1155             


Asp Arg  Cys Ala Arg Gly His  Ser Gln Glu Phe Pro  Thr Cys Leu 
    1160                 1165                 1170             


Gln Cys  His Leu Cys Phe Asp  Gln Trp Asp His Thr  Ile Ser Ser 
    1175                 1180                 1185             


Leu Ser  Lys Ala Val Gln Gly  Leu Met Arg Leu Ala  Ala Asn Met 
    1190                 1195                 1200             


Glu Asp  Lys Arg Glu Thr Leu  Pro Val Cys Glu Ala  Asp Phe Lys 
    1205                 1210                 1215             


Asp Leu  Arg Gly Asn Val Ser  Glu Ile Glu Arg Ile  Leu Lys His 
    1220                 1225                 1230             


Pro Val  Phe Pro Ser Gly Lys  Phe Leu Lys Val Lys  Asp Tyr His 
    1235                 1240                 1245             


Asp Ser  Val Arg Arg Gln Ile  Met Gln Leu Asn Glu  Gln Leu Lys 
    1250                 1255                 1260             


Ala Val  Tyr Glu Phe Gln Asp  Leu Lys Asp Thr Ile  Glu Arg Ala 
    1265                 1270                 1275             


Lys Asn  Glu Ala Asp Leu Leu  Leu Glu Asp Leu Gln  Glu Glu Ile 
    1280                 1285                 1290             


Asp Leu  Gln Ser Ser Val Leu  Asn Ala Ser Ile Ala  Asp Ser Ser 
    1295                 1300                 1305             


Glu Asn  Ile Lys Lys Tyr Tyr  His Ile Ser Ser Ser  Ala Glu Lys 
    1310                 1315                 1320             


Lys Ile  Asn Glu Thr Ser Ser  Thr Ile Asn Thr Ser  Ala Asn Thr 
    1325                 1330                 1335             


Arg Asn  Asp Leu Leu Thr Ile  Leu Asp Thr Leu Thr  Ser Lys Gly 
    1340                 1345                 1350             


Asn Leu  Ser Leu Glu Arg Leu  Lys Gln Ile Lys Ile  Pro Asp Ile 
    1355                 1360                 1365             


Gln Ile  Leu Asn Glu Lys Val  Cys Gly Asp Pro Gly  Asn Val Pro 
    1370                 1375                 1380             


Cys Val  Pro Leu Pro Cys Gly  Gly Ala Leu Cys Thr  Gly Arg Lys 
    1385                 1390                 1395             


Gly His  Arg Lys Cys Arg Gly  Pro Gly Cys His Gly  Ser Leu Thr 
    1400                 1405                 1410             


Leu Ser  Thr Asn Ala Leu Gln  Lys Ala Gln Glu Ala  Lys Ser Ile 
    1415                 1420                 1425             


Ile Arg  Asn Leu Asp Lys Gln  Val Arg Gly Leu Lys  Asn Gln Ile 
    1430                 1435                 1440             


Glu Ser  Ile Ser Glu Gln Ala  Glu Val Ser Lys Asn  Asn Ala Leu 
    1445                 1450                 1455             


Gln Leu  Arg Glu Lys Leu Gly  Asn Ile Arg Asn Gln  Ser Asp Ser 
    1460                 1465                 1470             


Glu Glu  Glu Asn Ile Asn Leu  Phe Ile Lys Lys Val  Lys Asn Phe 
    1475                 1480                 1485             


Leu Leu  Glu Glu Asn Val Pro  Pro Glu Asp Ile Glu  Lys Val Ala 
    1490                 1495                 1500             


Asn Gly  Val Leu Asp Ile His  Leu Pro Ile Pro Ser  Gln Asn Leu 
    1505                 1510                 1515             


Thr Asp  Glu Leu Val Lys Ile  Gln Lys His Met Gln  Leu Cys Glu 
    1520                 1525                 1530             


Asp Tyr  Arg Thr Asp Glu Asn  Arg Leu Asn Glu Glu  Ala Asp Gly 
    1535                 1540                 1545             


Ala Gln  Lys Leu Leu Val Lys  Ala Lys Ala Ala Glu  Lys Ala Ala 
    1550                 1555                 1560             


Asn Ile  Leu Leu Asn Leu Asp  Lys Thr Leu Asn Gln  Leu Gln Gln 
    1565                 1570                 1575             


Ala Gln  Ile Thr Gln Gly Arg  Ala Asn Ser Thr Ile  Thr Gln Leu 
    1580                 1585                 1590             


Thr Ala  Asn Ile Thr Lys Ile  Lys Lys Asn Val Leu  Gln Ala Glu 
    1595                 1600                 1605             


Asn Gln  Thr Arg Glu Met Lys  Ser Glu Leu Glu Leu  Ala Lys Gln 
    1610                 1615                 1620             


Arg Ser  Gly Leu Glu Asp Gly  Leu Ser Leu Leu Gln  Thr Lys Leu 
    1625                 1630                 1635             


Gln Arg  His Gln Asp His Ala  Val Asn Ala Lys Val  Gln Ala Glu 
    1640                 1645                 1650             


Ser Ala  Gln His Gln Ala Gly  Ser Leu Glu Lys Glu  Phe Val Glu 
    1655                 1660                 1665             


Leu Lys  Lys Gln Tyr Ala Ile  Leu Gln Arg Lys Thr  Ser Thr Thr 
    1670                 1675                 1680             


Gly Leu  Thr Lys Glu Thr Leu  Gly Lys Val Lys Gln  Leu Lys Asp 
    1685                 1690                 1695             


Ala Ala  Glu Lys Leu Ala Gly  Asp Thr Glu Ala Lys  Ile Arg Arg 
    1700                 1705                 1710             


Ile Thr  Asp Leu Glu Arg Lys  Ile Gln Asp Leu Asn  Leu Ser Arg 
    1715                 1720                 1725             


Gln Ala  Lys Ala Asp Gln Leu  Arg Ile Leu Glu Asp  Gln Val Val 
    1730                 1735                 1740             


Ala Ile  Lys Asn Glu Ile Val  Glu Gln Glu Lys Lys  Tyr Ala Arg 
    1745                 1750                 1755             


Cys Tyr  Ser 
    1760     


<210>  59
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Phe Leu Leu Pro Leu Pro Ala Ala Gly Arg Val Val Val Arg Arg 
1               5                   10                  15      


Leu Ala Val Arg Arg Phe Gly Ser Arg Ser Leu Ser Thr Ala Asp Met 
            20                  25                  30          


Thr Lys Gly Leu Val Leu Gly Ile Tyr Ser Lys Glu Lys Glu Asp Asp 
        35                  40                  45              


Val Pro Gln Phe Thr Ser Ala Gly Glu Asn Phe Asp Lys Leu Leu Ala 
    50                  55                  60                  


Gly Lys Leu Arg Glu Thr Leu Asn Ile Ser Gly Pro Pro Leu Lys Ala 
65                  70                  75                  80  


Gly Lys Thr Arg Thr Phe Tyr Gly Leu His Gln Asp Phe Pro Ser Val 
                85                  90                  95      


Val Leu Val Gly Leu Gly Lys Lys Ala Ala Gly Ile Asp Glu Gln Glu 
            100                 105                 110         


Asn Trp His Glu Gly Lys Glu Asn Ile Arg Ala Ala Val Ala Ala Gly 
        115                 120                 125             


Cys Arg Gln Ile Gln Asp Leu Glu Leu Ser Ser Val Glu Val Asp Pro 
    130                 135                 140                 


Cys Gly Asp Ala Gln Ala Ala Ala Glu Gly Ala Val Leu Gly Leu Tyr 
145                 150                 155                 160 


Glu Tyr Asp Asp Leu Lys Gln Lys Lys Lys Met Ala Val Ser Ala Lys 
                165                 170                 175     


Leu Tyr Gly Ser Gly Asp Gln Glu Ala Trp Gln Lys Gly Val Leu Phe 
            180                 185                 190         


Ala Ser Gly Gln Asn Leu Ala Arg Gln Leu Met Glu Thr Pro Ala Asn 
        195                 200                 205             


Glu Met Thr Pro Thr Arg Phe Ala Glu Ile Ile Glu Lys Asn Leu Lys 
    210                 215                 220                 


Ser Ala Ser Ser Lys Thr Glu Val His Ile Arg Pro Lys Ser Trp Ile 
225                 230                 235                 240 


Glu Glu Gln Ala Met Gly Ser Phe Leu Ser Val Ala Lys Gly Ser Asp 
                245                 250                 255     


Glu Pro Pro Val Phe Leu Glu Ile His Tyr Lys Gly Ser Pro Asn Ala 
            260                 265                 270         


Asn Glu Pro Pro Leu Val Phe Val Gly Lys Gly Ile Thr Phe Asp Ser 
        275                 280                 285             


Gly Gly Ile Ser Ile Lys Ala Ser Ala Asn Met Asp Leu Met Arg Ala 
    290                 295                 300                 


Asp Met Gly Gly Ala Ala Thr Ile Cys Ser Ala Ile Val Ser Ala Ala 
305                 310                 315                 320 


Lys Leu Asn Leu Pro Ile Asn Ile Ile Gly Leu Ala Pro Leu Cys Glu 
                325                 330                 335     


Asn Met Pro Ser Gly Lys Ala Asn Lys Pro Gly Asp Val Val Arg Ala 
            340                 345                 350         


Lys Asn Gly Lys Thr Ile Gln Val Asp Asn Thr Asp Ala Glu Gly Arg 
        355                 360                 365             


Leu Ile Leu Ala Asp Ala Leu Cys Tyr Ala His Thr Phe Asn Pro Lys 
    370                 375                 380                 


Val Ile Leu Asn Ala Ala Thr Leu Thr Gly Ala Met Asp Val Ala Leu 
385                 390                 395                 400 


Gly Ser Gly Ala Thr Gly Val Phe Thr Asn Ser Ser Trp Leu Trp Asn 
                405                 410                 415     


Lys Leu Phe Glu Ala Ser Ile Glu Thr Gly Asp Arg Val Trp Arg Met 
            420                 425                 430         


Pro Leu Phe Glu His Tyr Thr Arg Gln Val Val Asp Cys Gln Leu Ala 
        435                 440                 445             


Asp Val Asn Asn Ile Gly Lys Tyr Arg Ser Ala Gly Ala Cys Thr Ala 
    450                 455                 460                 


Ala Ala Phe Leu Lys Glu Phe Val Thr His Pro Lys Trp Ala His Leu 
465                 470                 475                 480 


Asp Ile Ala Gly Val Met Thr Asn Lys Asp Glu Val Pro Tyr Leu Arg 
                485                 490                 495     


Lys Gly Met Thr Gly Arg Pro Thr Arg Thr Leu Ile Glu Phe Leu Leu 
            500                 505                 510         


Arg Phe Ser Gln Asp Asn Ala 
        515                 


<210>  60
<211>  808
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Thr Ser Pro Ala Ala Ala Gln Ser Arg Glu Ile Asp Cys Leu Ser 
1               5                   10                  15      


Pro Glu Ala Gln Lys Leu Ala Glu Ala Arg Leu Ala Ala Lys Arg Ala 
            20                  25                  30          


Ala Arg Ala Glu Ala Arg Glu Ile Arg Met Lys Glu Leu Glu Arg Gln 
        35                  40                  45              


Gln Lys Glu Glu Asp Ser Glu Arg Tyr Ser Arg Arg Ser Arg Arg Asn 
    50                  55                  60                  


Thr Ser Ala Ser Asp Glu Asp Glu Arg Met Ser Val Gly Ser Arg Gly 
65                  70                  75                  80  


Ser Leu Arg Val Glu Glu Arg Pro Glu Lys Asp Phe Thr Glu Lys Gly 
                85                  90                  95      


Ser Arg Asn Met Pro Gly Leu Ser Ala Ala Thr Leu Ala Ser Leu Gly 
            100                 105                 110         


Gly Thr Ser Ser Arg Arg Gly Ser Gly Asp Thr Ser Ile Ser Ile Asp 
        115                 120                 125             


Thr Glu Ala Ser Ile Arg Glu Ile Lys Glu Leu Asn Glu Leu Lys Asp 
    130                 135                 140                 


Gln Ile Gln Asp Val Glu Gly Lys Tyr Met Gln Gly Leu Lys Glu Met 
145                 150                 155                 160 


Lys Asp Ser Leu Ala Glu Val Glu Glu Lys Tyr Lys Lys Ala Met Val 
                165                 170                 175     


Ser Asn Ala Gln Leu Asp Asn Glu Lys Thr Asn Phe Met Tyr Gln Val 
            180                 185                 190         


Asp Thr Leu Lys Asp Met Leu Leu Glu Leu Glu Glu Gln Leu Ala Glu 
        195                 200                 205             


Ser Arg Arg Gln Tyr Glu Glu Lys Asn Lys Glu Phe Glu Arg Glu Lys 
    210                 215                 220                 


His Ala His Ser Ile Leu Gln Phe Gln Phe Ala Glu Val Lys Glu Ala 
225                 230                 235                 240 


Leu Lys Gln Arg Glu Glu Met Leu Glu Lys His Gly Ile Ile Leu Asn 
                245                 250                 255     


Ser Glu Ile Ala Thr Asn Gly Glu Thr Ser Asp Thr Leu Asn Asn Val 
            260                 265                 270         


Gly Tyr Gln Gly Pro Thr Lys Met Thr Lys Glu Glu Leu Asn Ala Leu 
        275                 280                 285             


Lys Ser Thr Gly Asp Gly Thr Leu Gly Arg Ala Ser Glu Val Glu Val 
    290                 295                 300                 


Lys Asn Glu Ile Val Ala Asn Val Gly Lys Arg Glu Ile Leu His Asn 
305                 310                 315                 320 


Thr Glu Lys Glu Gln His Thr Glu Asp Thr Val Lys Asp Cys Val Asp 
                325                 330                 335     


Ile Glu Val Phe Pro Ala Gly Glu Asn Thr Glu Asp Gln Lys Ser Ser 
            340                 345                 350         


Glu Asp Thr Ala Pro Phe Leu Gly Thr Leu Ala Gly Ala Thr Tyr Glu 
        355                 360                 365             


Glu Gln Val Gln Ser Gln Ile Leu Glu Ser Ser Ser Leu Pro Glu Asn 
    370                 375                 380                 


Thr Val Gln Val Glu Ser Asn Glu Val Met Gly Ala Pro Asp Asp Arg 
385                 390                 395                 400 


Thr Arg Thr Pro Leu Glu Pro Ser Asn Cys Trp Ser Asp Leu Asp Gly 
                405                 410                 415     


Gly Asn His Thr Glu Asn Val Gly Glu Ala Ala Val Thr Gln Val Glu 
            420                 425                 430         


Glu Gln Ala Gly Thr Val Ala Ser Cys Pro Leu Gly His Ser Asp Asp 
        435                 440                 445             


Thr Val Tyr His Asp Asp Lys Cys Met Val Glu Val Pro Gln Glu Leu 
    450                 455                 460                 


Glu Thr Ser Thr Gly His Ser Leu Glu Lys Glu Phe Thr Asn Gln Glu 
465                 470                 475                 480 


Ala Ala Glu Pro Lys Glu Val Pro Ala His Ser Thr Glu Val Gly Arg 
                485                 490                 495     


Asp His Asn Glu Glu Glu Gly Glu Glu Thr Gly Leu Arg Asp Glu Lys 
            500                 505                 510         


Pro Ile Lys Thr Glu Val Pro Gly Ser Pro Ala Gly Thr Glu Gly Asn 
        515                 520                 525             


Cys Gln Glu Ala Thr Gly Pro Ser Thr Val Asp Thr Gln Asn Glu Pro 
    530                 535                 540                 


Leu Asp Met Lys Glu Pro Asp Glu Glu Lys Ser Asp Gln Gln Gly Glu 
545                 550                 555                 560 


Ala Leu Asp Ser Ser Gln Lys Lys Thr Lys Asn Lys Lys Lys Lys Asn 
                565                 570                 575     


Lys Lys Lys Lys Ser Pro Val Pro Val Glu Thr Leu Lys Asp Val Lys 
            580                 585                 590         


Lys Glu Leu Thr Tyr Gln Asn Thr Asp Leu Ser Glu Ile Lys Glu Glu 
        595                 600                 605             


Glu Gln Val Lys Ser Thr Asp Arg Lys Ser Ala Val Glu Ala Gln Asn 
    610                 615                 620                 


Glu Val Thr Glu Asn Pro Lys Gln Lys Ile Ala Ala Glu Ser Ser Glu 
625                 630                 635                 640 


Asn Val Asp Cys Pro Glu Asn Pro Lys Ile Lys Leu Asp Gly Lys Leu 
                645                 650                 655     


Asp Gln Glu Gly Asp Asp Val Gln Thr Ala Ala Glu Glu Val Leu Ala 
            660                 665                 670         


Asp Gly Asp Thr Leu Asp Phe Glu Asp Asp Thr Val Gln Ser Ser Gly 
        675                 680                 685             


Pro Arg Ala Gly Gly Glu Glu Leu Asp Glu Gly Val Ala Lys Asp Asn 
    690                 695                 700                 


Ala Lys Ile Asp Gly Ala Thr Gln Ser Ser Pro Ala Glu Pro Lys Ser 
705                 710                 715                 720 


Glu Asp Ala Asp Arg Cys Thr Leu Pro Glu His Glu Ser Pro Ser Gln 
                725                 730                 735     


Asp Ile Ser Asp Ala Cys Glu Ala Glu Ser Thr Glu Arg Cys Glu Met 
            740                 745                 750         


Ser Glu His Pro Ser Gln Thr Val Arg Lys Ala Leu Asp Ser Asn Ser 
        755                 760                 765             


Leu Glu Asn Asp Asp Leu Ser Ala Pro Gly Arg Glu Pro Gly His Phe 
    770                 775                 780                 


Asn Pro Glu Ser Arg Glu Asp Thr Arg Gly Gly Asn Glu Lys Gly Lys 
785                 790                 795                 800 


Ser Lys Glu Asp Cys Thr Met Ser 
                805             


<210>  61
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ala Ala Ala Ala Val Ser Glu Ser Trp Pro Glu Leu Glu Leu Ala 
1               5                   10                  15      


Glu Arg Glu Arg Arg Arg Glu Leu Leu Leu Thr Gly Pro Gly Leu Glu 
            20                  25                  30          


Glu Arg Val Arg Ala Ala Gly Gly Gln Leu Pro Pro Arg Leu Phe Thr 
        35                  40                  45              


Leu Pro Leu Leu His Tyr Leu Glu Val Ser Gly Cys Gly Ser Leu Arg 
    50                  55                  60                  


Ala Pro Gly Pro Gly Leu Ala Gln Gly Leu Pro Gln Leu His Ser Leu 
65                  70                  75                  80  


Val Leu Arg Arg Asn Ala Leu Gly Pro Gly Leu Ser Pro Glu Leu Gly 
                85                  90                  95      


Pro Leu Pro Ala Leu Arg Val Leu Asp Leu Ser Gly Asn Ala Leu Glu 
            100                 105                 110         


Ala Leu Pro Pro Gly Gln Gly Leu Gly Pro Ala Glu Pro Pro Gly Leu 
        115                 120                 125             


Pro Gln Leu Gln Ser Leu Asn Leu Ser Gly Asn Arg Leu Arg Glu Leu 
    130                 135                 140                 


Pro Ala Asp Leu Ala Arg Cys Ala Pro Arg Leu Gln Ser Leu Asn Leu 
145                 150                 155                 160 


Thr Gly Asn Cys Leu Asp Ser Phe Pro Ala Glu Leu Phe Arg Pro Gly 
                165                 170                 175     


Ala Leu Pro Leu Leu Ser Glu Leu Ala Ala Ala Asp Asn Cys Leu Arg 
            180                 185                 190         


Glu Leu Ser Pro Asp Ile Ala His Leu Ala Ser Leu Lys Thr Leu Asp 
        195                 200                 205             


Leu Ser Asn Asn Gln Leu Ser Glu Ile Pro Ala Glu Leu Ala Asp Cys 
    210                 215                 220                 


Pro Lys Leu Lys Glu Ile Asn Phe Arg Gly Asn Lys Leu Arg Asp Lys 
225                 230                 235                 240 


Arg Leu Glu Lys Met Val Ser Gly Cys Gln Thr Arg Ser Ile Leu Glu 
                245                 250                 255     


Tyr Leu Arg Val Gly Gly Arg Gly Gly Gly Lys Gly Lys Gly Arg Ala 
            260                 265                 270         


Glu Gly Ser Glu Lys Glu Glu Ser Arg Arg Lys Arg Arg Glu Arg Lys 
        275                 280                 285             


Gln Arg Arg Glu Gly Gly Asp Gly Glu Glu Gln Asp Val Gly Asp Ala 
    290                 295                 300                 


Gly Arg Leu Leu Leu Arg Val Leu His Val Ser Glu Asn Pro Val Pro 
305                 310                 315                 320 


Leu Thr Val Arg Val Ser Pro Glu Val Arg Asp Val Arg Pro Tyr Ile 
                325                 330                 335     


Val Gly Ala Val Val Arg Gly Met Asp Leu Gln Pro Gly Asn Ala Leu 
            340                 345                 350         


Lys Arg Phe Leu Thr Ser Gln Thr Lys Leu His Glu Asp Leu Cys Glu 
        355                 360                 365             


Lys Arg Thr Ala Ala Thr Leu Ala Thr His Glu Leu Arg Ala Val Lys 
    370                 375                 380                 


Gly Pro Leu Leu Tyr Cys Ala Arg Pro Pro Gln Asp Leu Lys Ile Val 
385                 390                 395                 400 


Pro Leu Gly Arg Lys Glu Ala Lys Ala Lys Glu Leu Val Arg Gln Leu 
                405                 410                 415     


Gln Leu Glu Ala Glu Glu Gln Arg Lys Gln Lys Lys Arg Gln Ser Val 
            420                 425                 430         


Ser Gly Leu His Arg Tyr Leu His Leu Leu Asp Gly Asn Glu Asn Tyr 
        435                 440                 445             


Pro Cys Leu Val Asp Ala Asp Gly Asp Val Ile Ser Phe Pro Pro Ile 
    450                 455                 460                 


Thr Asn Ser Glu Lys Thr Lys Val Lys Lys Thr Thr Ser Asp Leu Phe 
465                 470                 475                 480 


Leu Glu Val Thr Ser Ala Thr Ser Leu Gln Ile Cys Lys Asp Val Met 
                485                 490                 495     


Asp Ala Leu Ile Leu Lys Met Ala Glu Met Lys Lys Tyr Thr Leu Glu 
            500                 505                 510         


Asn Lys Glu Glu Gly Ser Leu Ser Asp Thr Glu Ala Asp Ala Val Ser 
        515                 520                 525             


Gly Gln Leu Pro Asp Pro Thr Thr Asn Pro Ser Ala Gly Lys Asp Gly 
    530                 535                 540                 


Pro Ser Leu Leu Val Val Glu Gln Val Arg Val Val Asp Leu Glu Gly 
545                 550                 555                 560 


Ser Leu Lys Val Val Tyr Pro Ser Lys Ala Asp Leu Ala Thr Ala Pro 
                565                 570                 575     


Pro His Val Thr Val Val Arg 
            580             


<210>  62
<211>  611
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Pro Glu Ile Val Asp Thr Cys Ser Leu Ala Ser Pro Ala Ser Val 
1               5                   10                  15      


Cys Arg Thr Lys His Leu His Leu Arg Cys Ser Val Asp Phe Thr Arg 
            20                  25                  30          


Arg Thr Leu Thr Gly Thr Ala Ala Leu Thr Val Gln Ser Gln Glu Asp 
        35                  40                  45              


Asn Leu Arg Ser Leu Val Leu Asp Thr Lys Asp Leu Thr Ile Glu Lys 
    50                  55                  60                  


Val Val Ile Asn Gly Gln Glu Val Lys Tyr Ala Leu Gly Glu Arg Gln 
65                  70                  75                  80  


Ser Tyr Lys Gly Ser Pro Met Glu Ile Ser Leu Pro Ile Ala Leu Ser 
                85                  90                  95      


Lys Asn Gln Glu Ile Val Ile Glu Ile Ser Phe Glu Thr Ser Pro Lys 
            100                 105                 110         


Ser Ser Ala Leu Gln Trp Leu Thr Pro Glu Gln Thr Ser Gly Lys Glu 
        115                 120                 125             


His Pro Tyr Leu Phe Ser Gln Cys Gln Ala Ile His Cys Arg Ala Ile 
    130                 135                 140                 


Leu Pro Cys Gln Asp Thr Pro Ser Val Lys Leu Thr Tyr Thr Ala Glu 
145                 150                 155                 160 


Val Ser Val Pro Lys Glu Leu Val Ala Leu Met Ser Ala Ile Arg Asp 
                165                 170                 175     


Gly Glu Thr Pro Asp Pro Glu Asp Pro Ser Arg Lys Ile Tyr Lys Phe 
            180                 185                 190         


Ile Gln Lys Val Pro Ile Pro Cys Tyr Leu Ile Ala Leu Val Val Gly 
        195                 200                 205             


Ala Leu Glu Ser Arg Gln Ile Gly Pro Arg Thr Leu Val Trp Ser Glu 
    210                 215                 220                 


Lys Glu Gln Val Glu Lys Ser Ala Tyr Glu Phe Ser Glu Thr Glu Ser 
225                 230                 235                 240 


Met Leu Lys Ile Ala Glu Asp Leu Gly Gly Pro Tyr Val Trp Gly Gln 
                245                 250                 255     


Tyr Asp Leu Leu Val Leu Pro Pro Ser Phe Pro Tyr Gly Gly Met Glu 
            260                 265                 270         


Asn Pro Cys Leu Thr Phe Val Thr Pro Thr Leu Leu Ala Gly Asp Lys 
        275                 280                 285             


Ser Leu Ser Asn Val Ile Ala His Glu Ile Ser His Ser Trp Thr Gly 
    290                 295                 300                 


Asn Leu Val Thr Asn Lys Thr Trp Asp His Phe Trp Leu Asn Glu Gly 
305                 310                 315                 320 


His Thr Val Tyr Leu Glu Arg His Ile Cys Gly Arg Leu Phe Gly Glu 
                325                 330                 335     


Lys Phe Arg His Phe Asn Ala Leu Gly Gly Trp Gly Glu Leu Gln Asn 
            340                 345                 350         


Ser Val Lys Thr Phe Gly Glu Thr His Pro Phe Thr Lys Leu Val Val 
        355                 360                 365             


Asp Leu Thr Asp Ile Asp Pro Asp Val Ala Tyr Ser Ser Val Pro Tyr 
    370                 375                 380                 


Glu Lys Gly Phe Ala Leu Leu Phe Tyr Leu Glu Gln Leu Leu Gly Gly 
385                 390                 395                 400 


Pro Glu Ile Phe Leu Gly Phe Leu Lys Ala Tyr Val Glu Lys Phe Ser 
                405                 410                 415     


Tyr Lys Ser Ile Thr Thr Asp Asp Trp Lys Asp Phe Leu Tyr Ser Tyr 
            420                 425                 430         


Phe Lys Asp Lys Val Asp Val Leu Asn Gln Val Asp Trp Asn Ala Trp 
        435                 440                 445             


Leu Tyr Ser Pro Gly Leu Pro Pro Ile Lys Pro Asn Tyr Asp Met Thr 
    450                 455                 460                 


Leu Thr Asn Ala Cys Ile Ala Leu Ser Gln Arg Trp Ile Thr Ala Lys 
465                 470                 475                 480 


Glu Asp Asp Leu Asn Ser Phe Asn Ala Thr Asp Leu Lys Asp Leu Ser 
                485                 490                 495     


Ser His Gln Leu Asn Glu Phe Leu Ala Gln Thr Leu Gln Arg Ala Pro 
            500                 505                 510         


Leu Pro Leu Gly His Ile Lys Arg Met Gln Glu Val Tyr Asn Phe Asn 
        515                 520                 525             


Ala Ile Asn Asn Ser Glu Ile Arg Phe Arg Trp Leu Arg Leu Cys Ile 
    530                 535                 540                 


Gln Ser Lys Trp Glu Asp Ala Ile Pro Leu Ala Leu Lys Met Ala Thr 
545                 550                 555                 560 


Glu Gln Gly Arg Met Lys Phe Thr Arg Pro Leu Phe Lys Asp Leu Ala 
                565                 570                 575     


Ala Phe Asp Lys Ser His Asp Gln Ala Val Arg Thr Tyr Gln Glu His 
            580                 585                 590         


Lys Ala Ser Met His Pro Val Thr Ala Met Leu Val Gly Lys Asp Leu 
        595                 600                 605             


Lys Val Asp 
    610     


<210>  63
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Asn Pro Asn Cys Ala Arg Cys Gly Lys Ile Val Tyr Pro Thr Glu 
1               5                   10                  15      


Lys Val Asn Cys Leu Asp Lys Phe Trp His Lys Ala Cys Phe His Cys 
            20                  25                  30          


Glu Thr Cys Lys Met Thr Leu Asn Met Lys Asn Tyr Lys Gly Tyr Glu 
        35                  40                  45              


Lys Lys Pro Tyr Cys Asn Ala His Tyr Pro Lys Gln Ser Phe Thr Met 
    50                  55                  60                  


Val Ala Asp Thr Pro Glu Asn Leu Arg Leu Lys Gln Gln Ser Glu Leu 
65                  70                  75                  80  


Gln Ser Gln Val Arg Tyr Lys Glu Glu Phe Glu Lys Asn Lys Gly Lys 
                85                  90                  95      


Gly Phe Ser Val Val Ala Asp Thr Pro Glu Leu Gln Arg Ile Lys Lys 
            100                 105                 110         


Thr Gln Asp Gln Ile Ser Asn Ile Lys Tyr His Glu Glu Phe Glu Lys 
        115                 120                 125             


Ser Arg Met Gly Pro Ser Gly Gly Glu Gly Met Glu Pro Glu Arg Arg 
    130                 135                 140                 


Asp Ser Gln Asp Gly Ser Ser Tyr Arg Arg Pro Leu Glu Gln Gln Gln 
145                 150                 155                 160 


Pro His His Ile Pro Thr Ser Ala Pro Val Tyr Gln Gln Pro Gln Gln 
                165                 170                 175     


Gln Pro Val Ala Gln Ser Tyr Gly Gly Tyr Lys Glu Pro Ala Ala Pro 
            180                 185                 190         


Val Ser Ile Gln Arg Ser Ala Pro Gly Gly Gly Gly Lys Arg Tyr Arg 
        195                 200                 205             


Ala Val Tyr Asp Tyr Ser Ala Ala Asp Glu Asp Glu Val Ser Phe Gln 
    210                 215                 220                 


Asp Gly Asp Thr Ile Val Asn Val Gln Gln Ile Asp Asp Gly Trp Met 
225                 230                 235                 240 


Tyr Gly Thr Val Glu Arg Thr Gly Asp Thr Gly Met Leu Pro Ala Asn 
                245                 250                 255     


Tyr Val Glu Ala Ile 
            260     


<210>  64
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Ser Leu Ser Ala Phe Thr Leu Phe Leu Ala Leu Ile Gly Gly Thr 
1               5                   10                  15      


Ser Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu Ser Ile Tyr Gly Gln 
            20                  25                  30          


Ser Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys Pro Glu Ser Tyr Pro 
        35                  40                  45              


Ser Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys Ser Val Pro Met Val 
    50                  55                  60                  


Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn Gln Ile Asp His 
65                  70                  75                  80  


Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu Gln Trp Leu Ile 
                85                  90                  95      


Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys Gly Arg Val Phe 
            100                 105                 110         


Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn His Asn Asn Leu 
        115                 120                 125             


Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu Glu Asp Leu Gln Leu 
    130                 135                 140                 


Thr His Asn Lys Ile Thr Lys Leu Gly Ser Phe Glu Gly Leu Val Asn 
145                 150                 155                 160 


Leu Thr Phe Ile His Leu Gln His Asn Arg Leu Lys Glu Asp Ala Val 
                165                 170                 175     


Ser Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser 
            180                 185                 190         


Phe Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu Pro Val Ser Leu Leu 
        195                 200                 205             


Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile Pro Asp Glu Tyr 
    210                 215                 220                 


Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg Leu Ser His Asn Glu 
225                 230                 235                 240 


Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe Asn Val Ser Ser Leu 
                245                 250                 255     


Val Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys Asn Ile Pro Thr Val 
            260                 265                 270         


Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val Asn Gln Leu Glu Lys 
        275                 280                 285             


Phe Asp Ile Lys Ser Phe Cys Lys Ile Leu Gly Pro Leu Ser Tyr Ser 
    290                 295                 300                 


Lys Ile Lys His Leu Arg Leu Asp Gly Asn Arg Ile Ser Glu Thr Ser 
305                 310                 315                 320 


Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala Asn Glu Val Thr 
                325                 330                 335     


Leu Asn 
        


<210>  65
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Pro Met Phe Ile Val Asn Thr Asn Val Pro Arg Ala Ser Val Pro 
1               5                   10                  15      


Asp Gly Phe Leu Ser Glu Leu Thr Gln Gln Leu Ala Gln Ala Thr Gly 
            20                  25                  30          


Lys Pro Pro Gln Tyr Ile Ala Val His Val Val Pro Asp Gln Leu Met 
        35                  40                  45              


Ala Phe Gly Gly Ser Ser Glu Pro Cys Ala Leu Cys Ser Leu His Ser 
    50                  55                  60                  


Ile Gly Lys Ile Gly Gly Ala Gln Asn Arg Ser Tyr Ser Lys Leu Leu 
65                  70                  75                  80  


Cys Gly Leu Leu Ala Glu Arg Leu Arg Ile Ser Pro Asp Arg Val Tyr 
                85                  90                  95      


Ile Asn Tyr Tyr Asp Met Asn Ala Ala Asn Val Gly Trp Asn Asn Ser 
            100                 105                 110         


Thr Phe Ala 
        115 


<210>  66
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Ser Glu Pro Ile Arg Val Leu Val Thr Gly Ala Ala Gly Gln Ile 
1               5                   10                  15      


Ala Tyr Ser Leu Leu Tyr Ser Ile Gly Asn Gly Ser Val Phe Gly Lys 
            20                  25                  30          


Asp Gln Pro Ile Ile Leu Val Leu Leu Asp Ile Thr Pro Met Met Gly 
        35                  40                  45              


Val Leu Asp Gly Val Leu Met Glu Leu Gln Asp Cys Ala Leu Pro Leu 
    50                  55                  60                  


Leu Lys Asp Val Ile Ala Thr Asp Lys Glu Asp Val Ala Phe Lys Asp 
65                  70                  75                  80  


Leu Asp Val Ala Ile Leu Val Gly Ser Met Pro Arg Arg Glu Gly Met 
                85                  90                  95      


Glu Arg Lys Asp Leu Leu Lys Ala Asn Val Lys Ile Phe Lys Ser Gln 
            100                 105                 110         


Gly Ala Ala Leu Asp Lys Tyr Ala Lys Lys Ser Val Lys Val Ile Val 
        115                 120                 125             


Val Gly Asn Pro Ala Asn Thr Asn Cys Leu Thr Ala Ser Lys Ser Ala 
    130                 135                 140                 


Pro Ser Ile Pro Lys Glu Asn Phe Ser Cys Leu Thr Arg Leu Asp His 
145                 150                 155                 160 


Asn Arg Ala Lys Ala Gln Ile Ala Leu Lys Leu Gly Val Thr Ala Asn 
                165                 170                 175     


Asp Val Lys Asn Val Ile Ile Trp Gly Asn His Ser Ser Thr Gln Tyr 
            180                 185                 190         


Pro Asp Val Asn His Ala Lys Val Lys Leu Gln Gly Lys Glu Val Gly 
        195                 200                 205             


Val Tyr Glu Ala Leu Lys Asp Asp Ser Trp Leu Lys Gly Glu Phe Val 
    210                 215                 220                 


Thr Thr Val Gln Gln Arg Gly Ala Ala Val Ile Lys Ala Arg Lys Leu 
225                 230                 235                 240 


Ser Ser Ala Met Ser Ala Ala Lys Ala Ile Cys Asp His Val Arg Asp 
                245                 250                 255     


Ile Trp Phe Gly Thr Pro Glu Gly Glu Phe Val Ser Met Gly Val Ile 
            260                 265                 270         


Ser Asp Gly Asn Ser Tyr Gly Val Pro Asp Asp Leu Leu Tyr Ser Phe 
        275                 280                 285             


Pro Val Val Ile Lys Asn Lys Thr Trp Lys Phe Val Glu Gly Leu Pro 
    290                 295                 300                 


Ile Asn Asp Phe Ser Arg Glu Lys Met Asp Leu Thr Ala Lys Glu Leu 
305                 310                 315                 320 


Thr Glu Glu Lys Glu Ser Ala Phe Glu Phe Leu Ser Ser Ala 
                325                 330                 


<210>  67
<211>  5430
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Ser Ser Ser Asp Glu Glu Thr Leu Ser Glu Arg Ser Cys Arg Ser 
1               5                   10                  15      


Glu Arg Ser Cys Arg Ser Glu Arg Ser Tyr Arg Ser Glu Arg Ser Gly 
            20                  25                  30          


Ser Leu Ser Pro Cys Pro Pro Gly Asp Thr Leu Pro Trp Asn Leu Pro 
        35                  40                  45              


Leu His Glu Gln Lys Lys Arg Lys Ser Gln Asp Ser Val Leu Asp Pro 
    50                  55                  60                  


Ala Glu Arg Ala Val Val Arg Val Ala Asp Glu Arg Asp Arg Val Gln 
65                  70                  75                  80  


Lys Lys Thr Phe Thr Lys Trp Val Asn Lys His Leu Met Lys Val Arg 
                85                  90                  95      


Lys His Ile Asn Asp Leu Tyr Glu Asp Leu Arg Asp Gly His Asn Leu 
            100                 105                 110         


Ile Ser Leu Leu Glu Val Leu Ser Gly Ile Lys Leu Pro Arg Glu Lys 
        115                 120                 125             


Gly Arg Met Arg Phe His Arg Leu Gln Asn Val Gln Ile Ala Leu Asp 
    130                 135                 140                 


Phe Leu Lys Gln Arg Gln Val Lys Leu Val Asn Ile Arg Asn Asp Asp 
145                 150                 155                 160 


Ile Thr Asp Gly Asn Pro Lys Leu Thr Leu Gly Leu Ile Trp Thr Ile 
                165                 170                 175     


Ile Leu His Phe Gln Ile Ser Asp Ile Tyr Ile Ser Gly Glu Ser Gly 
            180                 185                 190         


Asp Met Ser Ala Lys Glu Lys Leu Leu Leu Trp Thr Gln Lys Val Thr 
        195                 200                 205             


Ala Gly Tyr Thr Gly Ile Lys Cys Thr Asn Phe Ser Ser Cys Trp Ser 
    210                 215                 220                 


Asp Gly Lys Met Phe Asn Ala Leu Ile His Arg Tyr Arg Pro Asp Leu 
225                 230                 235                 240 


Val Asp Met Glu Arg Val Gln Ile Gln Ser Asn Arg Glu Asn Leu Glu 
                245                 250                 255     


Gln Ala Phe Glu Val Ala Glu Arg Leu Gly Val Thr Arg Leu Leu Asp 
            260                 265                 270         


Ala Glu Asp Val Asp Val Pro Ser Pro Asp Glu Lys Ser Val Ile Thr 
        275                 280                 285             


Tyr Val Ser Ser Ile Tyr Asp Ala Phe Pro Lys Val Pro Glu Gly Gly 
    290                 295                 300                 


Glu Gly Ile Ser Ala Thr Glu Val Asp Ser Arg Trp Gln Glu Tyr Gln 
305                 310                 315                 320 


Ser Arg Val Asp Ser Leu Ile Pro Trp Ile Lys Gln His Thr Ile Leu 
                325                 330                 335     


Met Ser Asp Lys Thr Phe Pro Gln Asn Pro Val Glu Leu Lys Ala Leu 
            340                 345                 350         


Tyr Asn Gln Tyr Ile His Phe Lys Glu Thr Glu Ile Leu Ala Lys Glu 
        355                 360                 365             


Arg Glu Lys Gly Arg Ile Glu Glu Leu Tyr Lys Leu Leu Glu Val Trp 
    370                 375                 380                 


Ile Glu Phe Gly Arg Ile Lys Leu Pro Gln Gly Tyr His Pro Asn Asp 
385                 390                 395                 400 


Val Glu Glu Glu Trp Gly Lys Leu Ile Ile Glu Met Leu Glu Arg Glu 
                405                 410                 415     


Lys Ser Leu Arg Pro Ala Val Glu Arg Leu Glu Leu Leu Leu Gln Ile 
            420                 425                 430         


Ala Asn Lys Ile Gln Asn Gly Ala Leu Asn Cys Glu Glu Lys Leu Thr 
        435                 440                 445             


Leu Ala Lys Asn Thr Leu Gln Ala Asp Ala Ala His Leu Glu Ser Gly 
    450                 455                 460                 


Gln Pro Val Gln Cys Glu Ser Asp Val Ile Met Tyr Ile Gln Glu Cys 
465                 470                 475                 480 


Glu Gly Leu Ile Arg Gln Leu Gln Val Asp Leu Gln Ile Leu Arg Asp 
                485                 490                 495     


Glu Asn Tyr Tyr Gln Leu Glu Glu Leu Ala Phe Arg Val Met Arg Leu 
            500                 505                 510         


Gln Asp Glu Leu Val Thr Leu Arg Leu Glu Cys Thr Asn Leu Tyr Arg 
        515                 520                 525             


Lys Gly His Phe Thr Ser Leu Glu Leu Val Pro Pro Ser Thr Leu Thr 
    530                 535                 540                 


Thr Thr His Leu Lys Ala Glu Pro Leu Thr Lys Ala Thr His Ser Ser 
545                 550                 555                 560 


Ser Thr Ser Trp Phe Arg Lys Pro Met Thr Arg Ala Glu Leu Val Ala 
                565                 570                 575     


Ile Ser Ser Ser Glu Asp Glu Gly Asn Leu Arg Phe Val Tyr Glu Leu 
            580                 585                 590         


Leu Ser Trp Val Glu Glu Met Gln Met Lys Leu Glu Arg Ala Glu Trp 
        595                 600                 605             


Gly Asn Asp Leu Pro Ser Val Glu Leu Gln Leu Glu Thr Gln Gln His 
    610                 615                 620                 


Ile His Thr Ser Val Glu Glu Leu Gly Ser Ser Val Lys Glu Ala Arg 
625                 630                 635                 640 


Leu Tyr Glu Gly Lys Met Ser Gln Asn Phe His Thr Ser Tyr Ala Glu 
                645                 650                 655     


Thr Leu Gly Lys Leu Glu Thr Gln Tyr Cys Lys Leu Lys Glu Thr Ser 
            660                 665                 670         


Ser Phe Arg Met Arg His Leu Gln Ser Leu His Lys Phe Val Ser Arg 
        675                 680                 685             


Ala Thr Ala Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Leu 
    690                 695                 700                 


Ala Tyr Asp Trp Ser Asp Asn Asn Ser Asn Ile Ser Ala Lys Arg Asn 
705                 710                 715                 720 


Tyr Phe Ser Glu Leu Thr Met Glu Leu Glu Glu Lys Gln Asp Val Phe 
                725                 730                 735     


Arg Ser Leu Gln Asp Thr Ala Glu Leu Leu Ser Leu Glu Asn His Pro 
            740                 745                 750         


Ala Lys Gln Thr Val Glu Ala Tyr Ser Ala Ala Val Gln Ser Gln Leu 
        755                 760                 765             


Gln Trp Met Lys Gln Leu Cys Leu Cys Val Glu Gln His Val Lys Glu 
    770                 775                 780                 


Asn Thr Ala Tyr Phe Gln Phe Phe Ser Asp Ala Arg Glu Leu Glu Ser 
785                 790                 795                 800 


Phe Leu Arg Asn Leu Gln Asp Ser Ile Lys Arg Lys Tyr Ser Cys Asp 
                805                 810                 815     


His Asn Thr Ser Leu Ser Arg Leu Glu Asp Leu Leu Gln Asp Ser Met 
            820                 825                 830         


Asp Glu Lys Glu Gln Leu Ile Gln Ser Lys Ser Ser Val Ala Ser Leu 
        835                 840                 845             


Val Gly Arg Ser Lys Thr Ile Val Gln Leu Lys Pro Arg Ser Pro Asp 
    850                 855                 860                 


His Val Leu Lys Asn Thr Ile Ser Val Lys Ala Val Cys Asp Tyr Arg 
865                 870                 875                 880 


Gln Ile Glu Ile Thr Ile Cys Lys Asn Asp Glu Cys Val Leu Glu Asp 
                885                 890                 895     


Asn Ser Gln Arg Thr Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu 
            900                 905                 910         


Ala Met Val Pro Ser Val Cys Phe Leu Ile Pro Pro Pro Asn Lys Asp 
        915                 920                 925             


Ala Ile Glu Met Ala Ser Arg Val Glu Gln Ser Tyr Gln Lys Val Met 
    930                 935                 940                 


Ala Leu Trp His Gln Leu His Val Asn Thr Lys Ser Leu Ile Ser Trp 
945                 950                 955                 960 


Asn Tyr Leu Arg Lys Asp Leu Asp Leu Val Gln Thr Trp Asn Leu Glu 
                965                 970                 975     


Lys Leu Arg Ser Ser Ala Pro Gly Glu Cys His Gln Ile Met Lys Asn 
            980                 985                 990         


Leu Gln Ala His Tyr Glu Asp Phe  Leu Gln Asp Ser Arg  Asp Ser Val 
        995                 1000                 1005             


Leu Phe  Ser Val Ala Asp Arg  Leu Arg Leu Glu Glu  Glu Val Glu 
    1010                 1015                 1020             


Ala Cys  Lys Ala Arg Phe Gln  His Leu Met Lys Ser  Met Glu Asn 
    1025                 1030                 1035             


Glu Asp  Lys Glu Glu Thr Val  Ala Lys Met Tyr Ile  Ser Glu Leu 
    1040                 1045                 1050             


Lys Asn  Ile Arg Leu Arg Leu  Glu Glu Tyr Glu Gln  Arg Val Val 
    1055                 1060                 1065             


Lys Arg  Ile Gln Ser Leu Ala  Ser Ser Arg Thr Asp  Arg Asp Ala 
    1070                 1075                 1080             


Trp Gln  Asp Asn Ala Leu Arg  Ile Ala Glu Gln Glu  His Thr Gln 
    1085                 1090                 1095             


Glu Asp  Leu Gln Gln Leu Arg  Ser Asp Leu Asp Ala  Val Ser Met 
    1100                 1105                 1110             


Lys Cys  Asp Ser Phe Leu His  Gln Ser Pro Ser Ser  Ser Ser Val 
    1115                 1120                 1125             


Pro Thr  Leu Arg Ser Glu Leu  Asn Leu Leu Val Glu  Lys Met Asp 
    1130                 1135                 1140             


His Val  Tyr Gly Leu Ser Thr  Val Tyr Leu Asn Lys  Leu Lys Thr 
    1145                 1150                 1155             


Val Asp  Val Ile Val Arg Ser  Ile Gln Asp Ala Glu  Leu Leu Val 
    1160                 1165                 1170             


Lys Gly  Tyr Glu Ile Lys Leu  Ser Gln Glu Glu Val  Val Leu Ala 
    1175                 1180                 1185             


Asp Leu  Ser Ala Leu Glu Ala  His Trp Ser Thr Leu  Arg His Trp 
    1190                 1195                 1200             


Leu Ser  Asp Val Lys Asp Lys  Asn Ser Val Phe Ser  Val Leu Asp 
    1205                 1210                 1215             


Glu Glu  Ile Ala Lys Ala Lys  Val Val Ala Glu Gln  Met Ser Arg 
    1220                 1225                 1230             


Leu Thr  Pro Glu Arg Asn Leu  Asp Leu Glu Arg Tyr  Gln Glu Lys 
    1235                 1240                 1245             


Gly Ser  Gln Leu Gln Glu Arg  Trp His Arg Val Ile  Ala Gln Leu 
    1250                 1255                 1260             


Glu Ile  Arg Gln Ser Glu Leu  Glu Ser Ile Gln Glu  Val Leu Gly 
    1265                 1270                 1275             


Asp Tyr  Arg Ala Cys His Gly  Thr Leu Ile Lys Trp  Ile Glu Glu 
    1280                 1285                 1290             


Thr Thr  Ala Gln Gln Glu Met  Met Lys Pro Gly Gln  Ala Glu Asp 
    1295                 1300                 1305             


Ser Arg  Val Leu Ser Glu Gln  Leu Ser Gln Gln Thr  Ala Leu Phe 
    1310                 1315                 1320             


Ala Glu  Ile Glu Arg Asn Gln  Thr Lys Leu Asp Gln  Cys Gln Lys 
    1325                 1330                 1335             


Phe Ser  Gln Gln Tyr Ser Thr  Ile Val Lys Asp Tyr  Glu Leu Gln 
    1340                 1345                 1350             


Leu Met  Thr Tyr Lys Ala Phe  Val Glu Ser Gln Gln  Lys Ser Pro 
    1355                 1360                 1365             


Gly Lys  Arg Arg Arg Met Leu  Ser Ser Ser Asp Ala  Ile Thr Gln 
    1370                 1375                 1380             


Glu Phe  Met Asp Leu Arg Thr  Arg Tyr Thr Ala Leu  Val Thr Leu 
    1385                 1390                 1395             


Thr Thr  Gln His Val Lys Tyr  Ile Ser Asp Ala Leu  Arg Arg Leu 
    1400                 1405                 1410             


Glu Glu  Glu Glu Lys Val Val  Glu Glu Glu Lys Gln  Glu His Val 
    1415                 1420                 1425             


Glu Lys  Val Lys Glu Leu Leu  Gly Trp Val Ser Thr  Leu Ala Arg 
    1430                 1435                 1440             


Asn Thr  Gln Gly Lys Ala Thr  Ser Ser Glu Thr Lys  Glu Ser Thr 
    1445                 1450                 1455             


Asp Ile  Glu Lys Ala Ile Leu  Glu Gln Gln Val Leu  Ser Glu Glu 
    1460                 1465                 1470             


Leu Thr  Thr Lys Lys Glu Gln  Val Ser Glu Ala Ile  Lys Thr Ser 
    1475                 1480                 1485             


Gln Ile  Phe Leu Ala Lys His  Gly His Lys Leu Ser  Glu Lys Glu 
    1490                 1495                 1500             


Lys Lys  Gln Ile Ser Glu Gln  Leu Asn Ala Leu Asn  Lys Ala Tyr 
    1505                 1510                 1515             


His Asp  Leu Cys Asp Gly Ser  Ala Asn Gln Leu Gln  Gln Leu Gln 
    1520                 1525                 1530             


Ser Gln  Leu Ala His Gln Thr  Glu Gln Lys Thr Leu  Gln Lys Gln 
    1535                 1540                 1545             


Gln Asn  Thr Cys His Gln Gln  Leu Glu Asp Leu Cys  Ser Trp Val 
    1550                 1555                 1560             


Gly Gln  Ala Glu Arg Ala Leu  Ala Gly His Gln Gly  Arg Thr Thr 
    1565                 1570                 1575             


Gln Gln  Asp Leu Ser Ala Leu  Gln Lys Asn Gln Ser  Asp Leu Lys 
    1580                 1585                 1590             


Asp Leu  Gln Asp Asp Ile Gln  Asn Arg Ala Thr Ser  Phe Ala Thr 
    1595                 1600                 1605             


Val Val  Lys Asp Ile Glu Gly  Phe Met Glu Glu Asn  Gln Thr Lys 
    1610                 1615                 1620             


Leu Ser  Pro Arg Glu Leu Thr  Ala Leu Arg Glu Lys  Leu His Gln 
    1625                 1630                 1635             


Ala Lys  Glu Gln Tyr Glu Ala  Leu Gln Glu Glu Thr  Arg Val Ala 
    1640                 1645                 1650             


Gln Lys  Glu Leu Glu Glu Ala  Val Thr Ser Ala Leu  Gln Gln Glu 
    1655                 1660                 1665             


Thr Glu  Lys Ser Lys Ala Ala  Lys Glu Leu Ala Glu  Asn Lys Lys 
    1670                 1675                 1680             


Lys Ile  Asp Ala Leu Leu Asp  Trp Val Thr Ser Val  Gly Ser Ser 
    1685                 1690                 1695             


Gly Gly  Gln Leu Leu Thr Asn  Leu Pro Gly Met Glu  Gln Leu Ser 
    1700                 1705                 1710             


Gly Ala  Ser Leu Glu Lys Gly  Ala Leu Asp Thr Thr  Asp Gly Tyr 
    1715                 1720                 1725             


Met Gly  Val Asn Gln Ala Pro  Glu Lys Leu Asp Lys  Gln Cys Glu 
    1730                 1735                 1740             


Met Met  Lys Ala Arg His Gln  Glu Leu Leu Ser Gln  Gln Gln Asn 
    1745                 1750                 1755             


Phe Ile  Leu Ala Thr Gln Ser  Ala Gln Ala Phe Leu  Asp Gln His 
    1760                 1765                 1770             


Gly His  Asn Leu Thr Pro Glu  Glu Gln Gln Met Leu  Gln Gln Lys 
    1775                 1780                 1785             


Leu Gly  Glu Leu Lys Glu Gln  Tyr Ser Thr Ser Leu  Ala Gln Ser 
    1790                 1795                 1800             


Glu Ala  Glu Leu Lys Gln Val  Gln Thr Leu Gln Asp  Glu Leu Gln 
    1805                 1810                 1815             


Lys Phe  Leu Gln Asp His Lys  Glu Phe Glu Ser Trp  Leu Glu Arg 
    1820                 1825                 1830             


Ser Glu  Lys Glu Leu Glu Asn  Met His Lys Gly Gly  Ser Ser Pro 
    1835                 1840                 1845             


Glu Thr  Leu Pro Ser Leu Leu  Lys Arg Gln Gly Ser  Phe Ser Glu 
    1850                 1855                 1860             


Asp Val  Ile Ser His Lys Gly  Asp Leu Arg Phe Val  Thr Ile Ser 
    1865                 1870                 1875             


Gly Gln  Lys Val Leu Asp Met  Glu Asn Ser Phe Lys  Glu Gly Lys 
    1880                 1885                 1890             


Glu Pro  Ser Glu Ile Gly Asn  Leu Val Lys Asp Lys  Leu Lys Asp 
    1895                 1900                 1905             


Ala Thr  Glu Arg Tyr Thr Ala  Leu His Ser Lys Cys  Thr Arg Leu 
    1910                 1915                 1920             


Gly Ser  His Leu Asn Met Leu  Leu Gly Gln Tyr His  Gln Phe Gln 
    1925                 1930                 1935             


Asn Ser  Ala Asp Ser Leu Gln  Ala Trp Met Gln Ala  Cys Glu Ala 
    1940                 1945                 1950             


Asn Val  Glu Lys Leu Leu Ser  Asp Thr Val Ala Ser  Asp Pro Gly 
    1955                 1960                 1965             


Val Leu  Gln Glu Gln Leu Ala  Thr Thr Lys Gln Leu  Gln Glu Glu 
    1970                 1975                 1980             


Leu Ala  Glu His Gln Val Pro  Val Glu Lys Leu Gln  Lys Val Ala 
    1985                 1990                 1995             


Arg Asp  Ile Met Glu Ile Glu  Gly Glu Pro Ala Pro  Asp His Arg 
    2000                 2005                 2010             


His Val  Gln Glu Thr Thr Asp  Ser Ile Leu Ser His  Phe Gln Ser 
    2015                 2020                 2025             


Leu Ser  Tyr Ser Leu Ala Glu  Arg Ser Ser Leu Leu  Gln Lys Ala 
    2030                 2035                 2040             


Ile Ala  Gln Ser Gln Ser Val  Gln Glu Ser Leu Glu  Ser Leu Leu 
    2045                 2050                 2055             


Gln Ser  Ile Gly Glu Val Glu  Gln Asn Leu Glu Gly  Lys Gln Val 
    2060                 2065                 2070             


Ser Ser  Leu Ser Ser Gly Val  Ile Gln Glu Ala Leu  Ala Thr Asn 
    2075                 2080                 2085             


Met Lys  Leu Lys Gln Asp Ile  Ala Arg Gln Lys Ser  Ser Leu Glu 
    2090                 2095                 2100             


Ala Thr  Arg Glu Met Val Thr  Arg Phe Met Glu Thr  Ala Asp Ser 
    2105                 2110                 2115             


Thr Thr  Ala Ala Val Leu Gln  Gly Lys Leu Ala Glu  Val Ser Gln 
    2120                 2125                 2130             


Arg Phe  Glu Gln Leu Cys Leu  Gln Gln Gln Glu Lys  Glu Ser Ser 
    2135                 2140                 2145             


Leu Lys  Lys Leu Leu Pro Gln  Ala Glu Met Phe Glu  His Leu Ser 
    2150                 2155                 2160             


Gly Lys  Leu Gln Gln Phe Met  Glu Asn Lys Ser Arg  Met Leu Ala 
    2165                 2170                 2175             


Ser Gly  Asn Gln Pro Asp Gln  Asp Ile Thr His Phe  Phe Gln Gln 
    2180                 2185                 2190             


Ile Gln  Glu Leu Asn Leu Glu  Met Glu Asp Gln Gln  Glu Asn Leu 
    2195                 2200                 2205             


Asp Thr  Leu Glu His Leu Val  Thr Glu Leu Ser Ser  Cys Gly Phe 
    2210                 2215                 2220             


Ala Leu  Asp Leu Cys Gln His  Gln Asp Arg Val Gln  Asn Leu Arg 
    2225                 2230                 2235             


Lys Asp  Phe Thr Glu Leu Gln  Lys Thr Val Lys Glu  Arg Glu Lys 
    2240                 2245                 2250             


Asp Ala  Ser Ser Cys Gln Glu  Gln Leu Asp Glu Phe  Arg Lys Leu 
    2255                 2260                 2265             


Val Arg  Thr Phe Gln Lys Trp  Leu Lys Glu Thr Glu  Gly Ser Ile 
    2270                 2275                 2280             


Pro Pro  Thr Glu Thr Ser Met  Ser Ala Lys Glu Leu  Glu Lys Gln 
    2285                 2290                 2295             


Ile Glu  His Leu Lys Ser Leu  Leu Asp Asp Trp Ala  Ser Lys Gly 
    2300                 2305                 2310             


Thr Leu  Val Glu Glu Ile Asn  Cys Lys Gly Thr Ser  Leu Glu Asn 
    2315                 2320                 2325             


Leu Ile  Met Glu Ile Thr Ala  Pro Asp Ser Gln Gly  Lys Thr Gly 
    2330                 2335                 2340             


Ser Ile  Leu Pro Ser Val Gly  Ser Ser Val Gly Ser  Val Asn Gly 
    2345                 2350                 2355             


Tyr His  Thr Cys Lys Asp Leu  Thr Glu Ile Gln Cys  Asp Met Ser 
    2360                 2365                 2370             


Asp Val  Asn Leu Lys Tyr Glu  Lys Leu Gly Gly Val  Leu His Glu 
    2375                 2380                 2385             


Arg Gln  Glu Ser Leu Gln Ala  Ile Leu Asn Arg Met  Glu Glu Val 
    2390                 2395                 2400             


His Lys  Glu Ala Asn Ser Val  Leu Gln Trp Leu Glu  Ser Lys Glu 
    2405                 2410                 2415             


Glu Val  Leu Lys Ser Met Asp  Ala Met Ser Ser Pro  Thr Lys Thr 
    2420                 2425                 2430             


Glu Thr  Val Lys Ala Gln Ala  Glu Ser Asn Lys Ala  Phe Leu Ala 
    2435                 2440                 2445             


Glu Leu  Glu Gln Asn Ser Pro  Lys Ile Gln Lys Val  Lys Glu Ala 
    2450                 2455                 2460             


Leu Ala  Gly Leu Leu Val Thr  Tyr Pro Asn Ser Gln  Glu Ala Glu 
    2465                 2470                 2475             


Asn Trp  Lys Lys Ile Gln Glu  Glu Leu Asn Ser Arg  Trp Glu Arg 
    2480                 2485                 2490             


Ala Thr  Glu Val Thr Val Ala  Arg Gln Arg Gln Leu  Glu Glu Ser 
    2495                 2500                 2505             


Ala Ser  His Leu Ala Cys Phe  Gln Ala Ala Glu Ser  Gln Leu Arg 
    2510                 2515                 2520             


Pro Trp  Leu Met Glu Lys Glu  Leu Met Met Gly Val  Leu Gly Pro 
    2525                 2530                 2535             


Leu Ser  Ile Asp Pro Asn Met  Leu Asn Ala Gln Lys  Gln Gln Val 
    2540                 2545                 2550             


Gln Phe  Met Leu Lys Glu Phe  Glu Ala Arg Arg Gln  Gln His Glu 
    2555                 2560                 2565             


Gln Leu  Asn Glu Ala Ala Gln  Gly Ile Leu Thr Gly  Pro Gly Asp 
    2570                 2575                 2580             


Val Ser  Leu Ser Thr Ser Gln  Val Gln Lys Glu Leu  Gln Ser Ile 
    2585                 2590                 2595             


Asn Gln  Lys Trp Val Glu Leu  Thr Asp Lys Leu Asn  Ser Arg Ser 
    2600                 2605                 2610             


Ser Gln  Ile Asp Gln Ala Ile  Val Lys Ser Thr Gln  Tyr Gln Glu 
    2615                 2620                 2625             


Leu Leu  Gln Asp Leu Ser Glu  Lys Val Arg Ala Val  Gly Gln Arg 
    2630                 2635                 2640             


Leu Ser  Val Gln Ser Ala Ile  Ser Thr Gln Pro Glu  Ala Val Lys 
    2645                 2650                 2655             


Gln Gln  Leu Glu Glu Thr Ser  Glu Ile Arg Ser Asp  Leu Glu Gln 
    2660                 2665                 2670             


Leu Asp  His Glu Val Lys Glu  Ala Gln Thr Leu Cys  Asp Glu Leu 
    2675                 2680                 2685             


Ser Val  Leu Ile Gly Glu Gln  Tyr Leu Lys Asp Glu  Leu Lys Lys 
    2690                 2695                 2700             


Arg Leu  Glu Thr Val Ala Leu  Pro Leu Gln Gly Leu  Glu Asp Leu 
    2705                 2710                 2715             


Ala Ala  Asp Arg Ile Asn Arg  Leu Gln Ala Ala Leu  Ala Ser Thr 
    2720                 2725                 2730             


Gln Gln  Phe Gln Gln Met Phe  Asp Glu Leu Arg Thr  Trp Leu Asp 
    2735                 2740                 2745             


Asp Lys  Gln Ser Gln Gln Ala  Lys Asn Cys Pro Ile  Ser Ala Lys 
    2750                 2755                 2760             


Leu Glu  Arg Leu Gln Ser Gln  Leu Gln Glu Asn Glu  Glu Phe Gln 
    2765                 2770                 2775             


Lys Ser  Leu Asn Gln His Ser  Gly Ser Tyr Glu Val  Ile Val Ala 
    2780                 2785                 2790             


Glu Gly  Glu Ser Leu Leu Leu  Ser Val Pro Pro Gly  Glu Glu Lys 
    2795                 2800                 2805             


Arg Thr  Leu Gln Asn Gln Leu  Val Glu Leu Lys Asn  His Trp Glu 
    2810                 2815                 2820             


Glu Leu  Ser Lys Lys Thr Ala  Asp Arg Gln Ser Arg  Leu Lys Asp 
    2825                 2830                 2835             


Cys Met  Gln Lys Ala Gln Lys  Tyr Gln Trp His Val  Glu Asp Leu 
    2840                 2845                 2850             


Val Pro  Trp Ile Glu Asp Cys  Lys Ala Lys Met Ser  Glu Leu Arg 
    2855                 2860                 2865             


Val Thr  Leu Asp Pro Val Gln  Leu Glu Ser Ser Leu  Leu Arg Ser 
    2870                 2875                 2880             


Lys Ala  Met Leu Asn Glu Val  Glu Lys Arg Arg Ser  Leu Leu Glu 
    2885                 2890                 2895             


Ile Leu  Asn Ser Ala Ala Asp  Ile Leu Ile Asn Ser  Ser Glu Ala 
    2900                 2905                 2910             


Asp Glu  Asp Gly Ile Arg Asp  Glu Lys Ala Gly Ile  Asn Gln Asn 
    2915                 2920                 2925             


Met Asp  Ala Val Thr Glu Glu  Leu Gln Ala Lys Thr  Gly Ser Leu 
    2930                 2935                 2940             


Glu Glu  Met Thr Gln Arg Leu  Arg Glu Phe Gln Glu  Ser Phe Lys 
    2945                 2950                 2955             


Asn Ile  Glu Lys Lys Val Glu  Gly Ala Lys His Gln  Leu Glu Ile 
    2960                 2965                 2970             


Phe Asp  Ala Leu Gly Ser Gln  Ala Cys Ser Asn Lys  Asn Leu Glu 
    2975                 2980                 2985             


Lys Leu  Arg Ala Gln Gln Glu  Val Leu Gln Ala Leu  Glu Pro Gln 
    2990                 2995                 3000             


Val Asp  Tyr Leu Arg Asn Phe  Thr Gln Gly Leu Val  Glu Asp Ala 
    3005                 3010                 3015             


Pro Asp  Gly Ser Asp Ala Ser  Gln Leu Leu His Gln  Ala Glu Val 
    3020                 3025                 3030             


Ala Gln  Gln Glu Phe Leu Glu  Val Lys Gln Arg Val  Asn Ser Gly 
    3035                 3040                 3045             


Cys Val  Met Met Glu Asn Lys  Leu Glu Gly Ile Gly  Gln Phe His 
    3050                 3055                 3060             


Cys Arg  Val Arg Glu Met Phe  Ser Gln Leu Ala Asp  Leu Asp Asp 
    3065                 3070                 3075             


Glu Leu  Asp Gly Met Gly Ala  Ile Gly Arg Asp Thr  Asp Ser Leu 
    3080                 3085                 3090             


Gln Ser  Gln Ile Glu Asp Val  Arg Leu Phe Leu Asn  Lys Ile His 
    3095                 3100                 3105             


Val Leu  Lys Leu Asp Ile Glu  Ala Ser Glu Ala Glu  Cys Arg His 
    3110                 3115                 3120             


Met Leu  Glu Glu Glu Gly Thr  Leu Asp Leu Leu Gly  Leu Lys Arg 
    3125                 3130                 3135             


Glu Leu  Glu Ala Leu Asn Lys  Gln Cys Gly Lys Leu  Thr Glu Arg 
    3140                 3145                 3150             


Gly Lys  Ala Arg Gln Glu Gln  Leu Glu Leu Thr Leu  Gly Arg Val 
    3155                 3160                 3165             


Glu Asp  Phe Tyr Arg Lys Leu  Lys Gly Leu Asn Asp  Ala Thr Thr 
    3170                 3175                 3180             


Ala Ala  Glu Glu Ala Glu Ala  Leu Gln Trp Val Val  Gly Thr Glu 
    3185                 3190                 3195             


Val Glu  Ile Ile Asn Gln Gln  Leu Ala Asp Phe Lys  Met Phe Gln 
    3200                 3205                 3210             


Lys Glu  Gln Val Asp Pro Leu  Gln Met Lys Leu Gln  Gln Val Asn 
    3215                 3220                 3225             


Gly Leu  Gly Gln Gly Leu Ile  Gln Ser Ala Gly Lys  Asp Cys Asp 
    3230                 3235                 3240             


Val Gln  Gly Leu Glu His Asp  Met Glu Glu Ile Asn  Ala Arg Trp 
    3245                 3250                 3255             


Asn Thr  Leu Asn Lys Lys Val  Ala Gln Arg Ile Ala  Gln Leu Gln 
    3260                 3265                 3270             


Glu Ala  Leu Leu His Cys Gly  Lys Phe Gln Asp Ala  Leu Glu Pro 
    3275                 3280                 3285             


Leu Leu  Ser Trp Leu Ala Asp  Thr Glu Glu Leu Ile  Ala Asn Gln 
    3290                 3295                 3300             


Lys Pro  Pro Ser Ala Glu Tyr  Lys Val Val Lys Ala  Gln Ile Gln 
    3305                 3310                 3315             


Glu Gln  Lys Leu Leu Gln Arg  Leu Leu Asp Asp Arg  Lys Ala Thr 
    3320                 3325                 3330             


Val Asp  Met Leu Gln Ala Glu  Gly Gly Arg Ile Ala  Gln Ser Ala 
    3335                 3340                 3345             


Glu Leu  Ala Asp Arg Glu Lys  Ile Thr Gly Gln Leu  Glu Ser Leu 
    3350                 3355                 3360             


Glu Ser  Arg Trp Thr Glu Leu  Leu Ser Lys Ala Ala  Ala Arg Gln 
    3365                 3370                 3375             


Lys Gln  Leu Glu Asp Ile Leu  Val Leu Ala Lys Gln  Phe His Glu 
    3380                 3385                 3390             


Thr Ala  Glu Pro Ile Ser Asp  Phe Leu Ser Val Thr  Glu Lys Lys 
    3395                 3400                 3405             


Leu Ala  Asn Ser Glu Pro Val  Gly Thr Gln Thr Ala  Lys Ile Gln 
    3410                 3415                 3420             


Gln Gln  Ile Ile Arg His Lys  Ala Leu Glu Glu Asp  Ile Glu Asn 
    3425                 3430                 3435             


His Ala  Thr Asp Val His Gln  Ala Val Lys Ile Gly  Gln Ser Leu 
    3440                 3445                 3450             


Ser Ser  Leu Thr Ser Pro Ala  Glu Gln Gly Val Leu  Ser Glu Lys 
    3455                 3460                 3465             


Ile Asp  Ser Leu Gln Ala Arg  Tyr Ser Glu Ile Gln  Asp Arg Cys 
    3470                 3475                 3480             


Cys Arg  Lys Ala Ala Leu Leu  Asp Gln Ala Leu Ser  Asn Ala Arg 
    3485                 3490                 3495             


Leu Phe  Gly Glu Asp Glu Val  Glu Val Leu Asn Trp  Leu Ala Glu 
    3500                 3505                 3510             


Val Glu  Asp Lys Leu Ser Ser  Val Phe Val Lys Asp  Phe Lys Gln 
    3515                 3520                 3525             


Asp Val  Leu His Arg Gln His  Ala Asp His Leu Ala  Leu Asn Glu 
    3530                 3535                 3540             


Glu Ile  Val Asn Arg Lys Lys  Asn Val Asp Gln Ala  Ile Lys Asn 
    3545                 3550                 3555             


Gly Gln  Ala Leu Leu Lys Gln  Thr Thr Gly Glu Glu  Val Leu Leu 
    3560                 3565                 3570             


Ile Gln  Glu Lys Leu Asp Gly  Ile Lys Thr Arg Tyr  Ala Asp Ile 
    3575                 3580                 3585             


Thr Val  Thr Ser Ser Lys Ala  Leu Arg Thr Leu Glu  Gln Ala Arg 
    3590                 3595                 3600             


Gln Leu  Ala Thr Lys Phe Gln  Ser Thr Tyr Glu Glu  Leu Thr Gly 
    3605                 3610                 3615             


Trp Leu  Arg Glu Val Glu Glu  Glu Leu Ala Thr Ser  Gly Gly Gln 
    3620                 3625                 3630             


Ser Pro  Thr Gly Glu Gln Ile  Pro Gln Phe Gln Gln  Arg Gln Lys 
    3635                 3640                 3645             


Glu Leu  Lys Lys Glu Val Met  Glu His Arg Leu Val  Leu Asp Thr 
    3650                 3655                 3660             


Val Asn  Glu Val Ser Arg Ala  Leu Leu Glu Leu Val  Pro Trp Arg 
    3665                 3670                 3675             


Ala Arg  Glu Gly Leu Asp Lys  Leu Val Ser Asp Ala  Asn Glu Gln 
    3680                 3685                 3690             


Tyr Lys  Leu Val Ser Asp Thr  Ile Gly Gln Arg Val  Asp Glu Ile 
    3695                 3700                 3705             


Asp Ala  Ala Ile Gln Arg Ser  Gln Gln Tyr Glu Gln  Ala Ala Asp 
    3710                 3715                 3720             


Ala Glu  Leu Ala Trp Val Ala  Glu Thr Lys Arg Lys  Leu Met Ala 
    3725                 3730                 3735             


Leu Gly  Pro Ile Arg Leu Glu  Gln Asp Gln Thr Thr  Ala Gln Leu 
    3740                 3745                 3750             


Gln Val  Gln Lys Ala Phe Ser  Ile Asp Ile Ile Arg  His Lys Asp 
    3755                 3760                 3765             


Ser Met  Asp Glu Leu Phe Ser  His Arg Ser Glu Ile  Phe Gly Thr 
    3770                 3775                 3780             


Cys Gly  Glu Glu Gln Lys Thr  Val Leu Gln Glu Lys  Thr Glu Ser 
    3785                 3790                 3795             


Leu Ile  Gln Gln Tyr Glu Ala  Ile Ser Leu Leu Asn  Ser Glu Arg 
    3800                 3805                 3810             


Tyr Ala  Arg Leu Glu Arg Ala  Gln Val Leu Val Asn  Gln Phe Trp 
    3815                 3820                 3825             


Glu Thr  Tyr Glu Glu Leu Ser  Pro Trp Ile Glu Glu  Thr Arg Ala 
    3830                 3835                 3840             


Leu Ile  Ala Gln Leu Pro Ser  Pro Ala Ile Asp His  Glu Gln Leu 
    3845                 3850                 3855             


Arg Gln  Gln Gln Glu Glu Met  Arg Gln Leu Arg Glu  Ser Ile Ala 
    3860                 3865                 3870             


Glu His  Lys Pro His Ile Asp  Lys Leu Leu Lys Ile  Gly Pro Gln 
    3875                 3880                 3885             


Leu Lys  Glu Leu Asn Pro Glu  Glu Gly Glu Met Val  Glu Glu Lys 
    3890                 3895                 3900             


Tyr Gln  Lys Ala Glu Asn Met  Tyr Ala Gln Ile Lys  Glu Glu Val 
    3905                 3910                 3915             


Arg Gln  Arg Ala Leu Ala Leu  Asp Glu Ala Val Ser  Gln Ser Thr 
    3920                 3925                 3930             


Gln Ile  Thr Glu Phe His Asp  Lys Ile Glu Pro Met  Leu Glu Thr 
    3935                 3940                 3945             


Leu Glu  Asn Leu Ser Ser Arg  Leu Arg Met Pro Pro  Leu Ile Pro 
    3950                 3955                 3960             


Ala Glu  Val Asp Lys Ile Arg  Glu Cys Ile Ser Asp  Asn Lys Ser 
    3965                 3970                 3975             


Ala Thr  Val Glu Leu Glu Lys  Leu Gln Pro Ser Phe  Glu Ala Leu 
    3980                 3985                 3990             


Lys Arg  Arg Gly Glu Glu Leu  Ile Gly Arg Ser Gln  Gly Ala Asp 
    3995                 4000                 4005             


Lys Asp  Leu Ala Ala Lys Glu  Ile Gln Asp Lys Leu  Asp Gln Met 
    4010                 4015                 4020             


Val Phe  Phe Trp Glu Asp Ile  Lys Ala Arg Ala Glu  Glu Arg Glu 
    4025                 4030                 4035             


Ile Lys  Phe Leu Asp Val Leu  Glu Leu Ala Glu Lys  Phe Trp Tyr 
    4040                 4045                 4050             


Asp Met  Ala Ala Leu Leu Thr  Thr Ile Lys Asp Thr  Gln Asp Ile 
    4055                 4060                 4065             


Val His  Asp Leu Glu Ser Pro  Gly Ile Asp Pro Ser  Ile Ile Lys 
    4070                 4075                 4080             


Gln Gln  Val Glu Ala Ala Glu  Thr Ile Lys Glu Glu  Thr Asp Gly 
    4085                 4090                 4095             


Leu His  Glu Glu Leu Glu Phe  Ile Arg Ile Leu Gly  Ala Asp Leu 
    4100                 4105                 4110             


Ile Phe  Ala Cys Gly Glu Thr  Glu Lys Pro Glu Val  Arg Lys Ser 
    4115                 4120                 4125             


Ile Asp  Glu Met Asn Asn Ala  Trp Glu Asn Leu Asn  Lys Thr Trp 
    4130                 4135                 4140             


Lys Glu  Arg Leu Glu Lys Leu  Glu Asp Ala Met Gln  Ala Ala Val 
    4145                 4150                 4155             


Gln Tyr  Gln Asp Thr Leu Gln  Ala Met Phe Asp Trp  Leu Asp Asn 
    4160                 4165                 4170             


Thr Val  Ile Lys Leu Cys Thr  Met Pro Pro Val Gly  Thr Asp Leu 
    4175                 4180                 4185             


Asn Thr  Val Lys Asp Gln Leu  Asn Glu Met Lys Glu  Phe Lys Val 
    4190                 4195                 4200             


Glu Val  Tyr Gln Gln Gln Ile  Glu Met Glu Lys Leu  Asn His Gln 
    4205                 4210                 4215             


Gly Glu  Leu Met Leu Lys Lys  Ala Thr Asp Glu Thr  Asp Arg Asp 
    4220                 4225                 4230             


Ile Ile  Arg Glu Pro Leu Thr  Glu Leu Lys His Leu  Trp Glu Asn 
    4235                 4240                 4245             


Leu Gly  Glu Lys Ile Ala His  Arg Gln His Lys Leu  Glu Gly Ala 
    4250                 4255                 4260             


Leu Leu  Ala Leu Gly Gln Phe  Gln His Ala Leu Glu  Glu Leu Met 
    4265                 4270                 4275             


Ser Trp  Leu Thr His Thr Glu  Glu Leu Leu Asp Ala  Gln Arg Pro 
    4280                 4285                 4290             


Ile Ser  Gly Asp Pro Lys Val  Ile Glu Val Glu Leu  Ala Lys His 
    4295                 4300                 4305             


His Val  Leu Lys Asn Asp Val  Leu Ala His Gln Ala  Thr Val Glu 
    4310                 4315                 4320             


Thr Val  Asn Lys Ala Gly Asn  Glu Leu Leu Glu Ser  Ser Ala Gly 
    4325                 4330                 4335             


Asp Asp  Ala Ser Ser Leu Arg  Ser Arg Leu Glu Ala  Met Asn Gln 
    4340                 4345                 4350             


Cys Trp  Glu Ser Val Leu Gln  Lys Thr Glu Glu Arg  Glu Gln Gln 
    4355                 4360                 4365             


Leu Gln  Ser Thr Leu Gln Gln  Ala Gln Gly Phe His  Ser Glu Ile 
    4370                 4375                 4380             


Glu Asp  Phe Leu Leu Glu Leu  Thr Arg Met Glu Ser  Gln Leu Ser 
    4385                 4390                 4395             


Ala Ser  Lys Pro Thr Gly Gly  Leu Pro Glu Thr Ala  Arg Glu Gln 
    4400                 4405                 4410             


Leu Asp  Thr His Met Glu Leu  Tyr Ser Gln Leu Lys  Ala Lys Glu 
    4415                 4420                 4425             


Glu Thr  Tyr Asn Gln Leu Leu  Asp Lys Gly Arg Leu  Met Leu Leu 
    4430                 4435                 4440             


Ser Arg  Asp Asp Ser Gly Ser  Gly Ser Lys Thr Glu  Gln Ser Val 
    4445                 4450                 4455             


Ala Leu  Leu Glu Gln Lys Trp  His Val Val Ser Ser  Lys Met Glu 
    4460                 4465                 4470             


Glu Arg  Lys Ser Lys Leu Glu  Glu Ala Leu Asn Leu  Ala Thr Glu 
    4475                 4480                 4485             


Phe Gln  Asn Ser Leu Gln Glu  Phe Ile Asn Trp Leu  Thr Leu Ala 
    4490                 4495                 4500             


Glu Gln  Ser Leu Asn Ile Ala  Ser Pro Pro Ser Leu  Ile Leu Asn 
    4505                 4510                 4515             


Thr Val  Leu Ser Gln Ile Glu  Glu His Lys Val Phe  Ala Asn Glu 
    4520                 4525                 4530             


Val Asn  Ala His Arg Asp Gln  Ile Ile Glu Leu Asp  Gln Thr Gly 
    4535                 4540                 4545             


Asn Gln  Leu Lys Phe Leu Ser  Gln Lys Gln Asp Val  Val Leu Ile 
    4550                 4555                 4560             


Lys Asn  Leu Leu Val Ser Val  Gln Ser Arg Trp Glu  Lys Val Val 
    4565                 4570                 4575             


Gln Arg  Ser Ile Glu Arg Gly  Arg Ser Leu Asp Asp  Ala Arg Lys 
    4580                 4585                 4590             


Arg Ala  Lys Gln Phe His Glu  Ala Trp Lys Lys Leu  Ile Asp Trp 
    4595                 4600                 4605             


Leu Glu  Asp Ala Glu Ser His  Leu Asp Ser Glu Leu  Glu Ile Ser 
    4610                 4615                 4620             


Asn Asp  Pro Asp Lys Ile Lys  Leu Gln Leu Ser Lys  His Lys Glu 
    4625                 4630                 4635             


Phe Gln  Lys Thr Leu Gly Gly  Lys Gln Pro Val Tyr  Asp Thr Thr 
    4640                 4645                 4650             


Ile Arg  Thr Gly Arg Ala Leu  Lys Glu Lys Thr Leu  Leu Pro Glu 
    4655                 4660                 4665             


Asp Ser  Gln Lys Leu Asp Asn  Phe Leu Gly Glu Val  Arg Asp Lys 
    4670                 4675                 4680             


Trp Asp  Thr Val Cys Gly Lys  Ser Val Glu Arg Gln  His Lys Leu 
    4685                 4690                 4695             


Glu Glu  Ala Leu Leu Phe Ser  Gly Gln Phe Met Asp  Ala Leu Gln 
    4700                 4705                 4710             


Ala Leu  Val Asp Trp Leu Tyr  Lys Val Glu Pro Gln  Leu Ala Glu 
    4715                 4720                 4725             


Asp Gln  Pro Val His Gly Asp  Leu Asp Leu Val Met  Asn Leu Met 
    4730                 4735                 4740             


Asp Ala  His Lys Val Phe Gln  Lys Glu Leu Gly Lys  Arg Thr Gly 
    4745                 4750                 4755             


Thr Val  Gln Val Leu Lys Arg  Ser Gly Arg Glu Leu  Ile Glu Asn 
    4760                 4765                 4770             


Ser Arg  Asp Asp Thr Thr Trp  Val Lys Gly Gln Leu  Gln Glu Leu 
    4775                 4780                 4785             


Ser Thr  Arg Trp Asp Thr Val  Cys Lys Leu Ser Val  Ser Lys Gln 
    4790                 4795                 4800             


Ser Arg  Leu Glu Gln Ala Leu  Lys Gln Ala Glu Val  Phe Arg Asp 
    4805                 4810                 4815             


Thr Val  His Met Leu Leu Glu  Trp Leu Ser Glu Ala  Glu Gln Thr 
    4820                 4825                 4830             


Leu Arg  Phe Arg Gly Ala Leu  Pro Asp Asp Thr Glu  Ala Leu Gln 
    4835                 4840                 4845             


Ser Leu  Ile Asp Thr His Lys  Glu Phe Met Lys Lys  Val Glu Glu 
    4850                 4855                 4860             


Lys Arg  Val Asp Val Asn Ser  Ala Val Ala Met Gly  Glu Val Ile 
    4865                 4870                 4875             


Leu Ala  Val Cys His Pro Asp  Cys Ile Thr Thr Ile  Lys His Trp 
    4880                 4885                 4890             


Ile Thr  Ile Ile Arg Ala Arg  Phe Glu Glu Val Leu  Thr Trp Ala 
    4895                 4900                 4905             


Lys Gln  His Gln Gln Arg Leu  Glu Thr Ala Leu Ser  Glu Leu Val 
    4910                 4915                 4920             


Ala Asn  Ala Glu Leu Leu Glu  Glu Leu Leu Ala Trp  Ile Gln Trp 
    4925                 4930                 4935             


Ala Glu  Thr Thr Leu Ile Gln  Arg Asp Gln Glu Pro  Ile Pro Gln 
    4940                 4945                 4950             


Asn Ile  Asp Arg Val Lys Ala  Leu Ile Ala Glu His  Gln Thr Phe 
    4955                 4960                 4965             


Met Glu  Glu Met Thr Arg Lys  Gln Pro Asp Val Asp  Arg Val Thr 
    4970                 4975                 4980             


Lys Thr  Tyr Lys Arg Lys Asn  Ile Glu Pro Thr His  Ala Pro Phe 
    4985                 4990                 4995             


Ile Glu  Lys Ser Arg Ser Gly  Gly Arg Lys Ser Leu  Ser Gln Pro 
    5000                 5005                 5010             


Thr Pro  Pro Pro Met Pro Ile  Leu Ser Gln Ser Glu  Ala Lys Asn 
    5015                 5020                 5025             


Pro Arg  Ile Asn Gln Leu Ser  Ala Arg Trp Gln Gln  Val Trp Leu 
    5030                 5035                 5040             


Leu Ala  Leu Glu Arg Gln Arg  Lys Leu Asn Asp Ala  Leu Asp Arg 
    5045                 5050                 5055             


Leu Glu  Glu Leu Lys Glu Phe  Ala Asn Phe Asp Phe  Asp Val Trp 
    5060                 5065                 5070             


Arg Lys  Lys Tyr Met Arg Trp  Met Asn His Lys Lys  Ser Arg Val 
    5075                 5080                 5085             


Met Asp  Phe Phe Arg Arg Ile  Asp Lys Asp Gln Asp  Gly Lys Ile 
    5090                 5095                 5100             


Thr Arg  Gln Glu Phe Ile Asp  Gly Ile Leu Ala Ser  Lys Phe Pro 
    5105                 5110                 5115             


Thr Thr  Lys Leu Glu Met Thr  Ala Val Ala Asp Ile  Phe Asp Arg 
    5120                 5125                 5130             


Asp Gly  Asp Gly Tyr Ile Asp  Tyr Tyr Glu Phe Val  Ala Ala Leu 
    5135                 5140                 5145             


His Pro  Asn Lys Asp Ala Tyr  Arg Pro Thr Thr Asp  Ala Asp Lys 
    5150                 5155                 5160             


Ile Glu  Asp Glu Val Thr Arg  Gln Val Ala Gln Cys  Lys Cys Ala 
    5165                 5170                 5175             


Lys Arg  Phe Gln Val Glu Gln  Ile Gly Glu Asn Lys  Tyr Arg Phe 
    5180                 5185                 5190             


Gly Asp  Ser Gln Gln Leu Arg  Leu Val Arg Ile Leu  Arg Ser Thr 
    5195                 5200                 5205             


Val Met  Val Arg Val Gly Gly  Gly Trp Met Ala Leu  Asp Glu Phe 
    5210                 5215                 5220             


Leu Val  Lys Asn Asp Pro Cys  Arg Ala Arg Gly Arg  Thr Asn Ile 
    5225                 5230                 5235             


Glu Leu  Arg Glu Lys Phe Ile  Leu Pro Glu Gly Ala  Ser Gln Gly 
    5240                 5245                 5250             


Met Thr  Pro Phe Arg Ser Arg  Gly Arg Arg Ser Lys  Pro Ser Ser 
    5255                 5260                 5265             


Arg Ala  Ala Ser Pro Thr Arg  Ser Ser Ser Ser Ala  Ser Gln Ser 
    5270                 5275                 5280             


Asn His  Ser Cys Thr Ser Met  Pro Ser Ser Pro Ala  Thr Pro Ala 
    5285                 5290                 5295             


Ser Gly  Thr Lys Val Ile Pro  Ser Ser Gly Ser Lys  Leu Lys Arg 
    5300                 5305                 5310             


Pro Thr  Pro Thr Phe His Ser  Ser Arg Thr Ser Leu  Ala Gly Asp 
    5315                 5320                 5325             


Thr Ser  Asn Ser Ser Ser Pro  Ala Ser Thr Gly Ala  Lys Thr Asn 
    5330                 5335                 5340             


Arg Ala  Asp Pro Lys Lys Ser  Ala Ser Arg Pro Gly  Ser Arg Ala 
    5345                 5350                 5355             


Gly Ser  Arg Ala Gly Ser Arg  Ala Ser Ser Arg Arg  Gly Ser Asp 
    5360                 5365                 5370             


Ala Ser  Asp Phe Asp Leu Leu  Glu Thr Gln Ser Ala  Cys Ser Asp 
    5375                 5380                 5385             


Thr Ser  Glu Ser Ser Ala Ala  Gly Gly Gln Gly Asn  Ser Arg Arg 
    5390                 5395                 5400             


Gly Leu  Asn Lys Pro Ser Lys  Ile Pro Thr Met Ser  Lys Lys Thr 
    5405                 5410                 5415             


Thr Thr  Ala Ser Pro Arg Thr  Pro Gly Pro Lys Arg  
    5420                 5425                 5430 


<210>  68
<211>  5030
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Ser Val Gly Arg Arg Lys Leu Ala Leu Leu Trp Ala Leu Ala Leu 
1               5                   10                  15      


Ala Leu Ala Cys Thr Arg His Thr Gly His Ala Gln Asp Gly Ser Ser 
            20                  25                  30          


Glu Ser Ser Tyr Lys His His Pro Ala Leu Ser Pro Ile Ala Arg Gly 
        35                  40                  45              


Pro Ser Gly Val Pro Leu Arg Gly Ala Thr Val Phe Pro Ser Leu Arg 
    50                  55                  60                  


Thr Ile Pro Val Val Arg Ala Ser Asn Pro Ala His Asn Gly Arg Val 
65                  70                  75                  80  


Cys Ser Thr Trp Gly Ser Phe His Tyr Lys Thr Phe Asp Gly Asp Val 
                85                  90                  95      


Phe Arg Phe Pro Gly Leu Cys Asn Tyr Val Phe Ser Glu His Cys Gly 
            100                 105                 110         


Ala Ala Tyr Glu Asp Phe Asn Ile Gln Leu Arg Arg Ser Gln Glu Ser 
        115                 120                 125             


Ala Ala Pro Thr Leu Ser Arg Val Leu Met Lys Val Asp Gly Val Val 
    130                 135                 140                 


Ile Gln Leu Thr Lys Gly Ser Val Leu Val Asn Gly His Pro Val Leu 
145                 150                 155                 160 


Leu Pro Phe Ser Gln Ser Gly Val Leu Ile Gln Gln Ser Ser Ser Tyr 
                165                 170                 175     


Thr Lys Val Glu Ala Arg Leu Gly Leu Val Leu Met Trp Asn His Asp 
            180                 185                 190         


Asp Ser Leu Leu Leu Glu Leu Asp Thr Lys Tyr Ala Asn Lys Thr Cys 
        195                 200                 205             


Gly Leu Cys Gly Asp Phe Asn Gly Met Pro Val Val Ser Glu Leu Leu 
    210                 215                 220                 


Ser His Asn Thr Lys Leu Thr Pro Met Glu Phe Gly Asn Leu Gln Lys 
225                 230                 235                 240 


Met Asp Asp Pro Thr Glu Gln Cys Gln Asp Pro Val Pro Glu Pro Pro 
                245                 250                 255     


Arg Asn Cys Ser Thr Gly Phe Gly Ile Cys Glu Glu Leu Leu His Gly 
            260                 265                 270         


Gln Leu Phe Ser Gly Cys Val Ala Leu Val Asp Val Gly Ser Tyr Leu 
        275                 280                 285             


Glu Ala Cys Arg Gln Asp Leu Cys Phe Cys Glu Asp Thr Asp Leu Leu 
    290                 295                 300                 


Ser Cys Val Cys His Thr Leu Ala Glu Tyr Ser Arg Gln Cys Thr His 
305                 310                 315                 320 


Ala Gly Gly Leu Pro Gln Asp Trp Arg Gly Pro Asp Phe Cys Pro Gln 
                325                 330                 335     


Lys Cys Pro Asn Asn Met Gln Tyr His Glu Cys Arg Ser Pro Cys Ala 
            340                 345                 350         


Asp Thr Cys Ser Asn Gln Glu His Ser Arg Ala Cys Glu Asp His Cys 
        355                 360                 365             


Val Ala Gly Cys Phe Cys Pro Glu Gly Thr Val Leu Asp Asp Ile Gly 
    370                 375                 380                 


Gln Thr Gly Cys Val Pro Val Ser Lys Cys Ala Cys Val Tyr Asn Gly 
385                 390                 395                 400 


Ala Ala Tyr Ala Pro Gly Ala Thr Tyr Ser Thr Asp Cys Thr Asn Cys 
                405                 410                 415     


Thr Cys Ser Gly Gly Arg Trp Ser Cys Gln Glu Val Pro Cys Pro Asp 
            420                 425                 430         


Thr Cys Ser Val Leu Gly Gly Ala His Phe Ser Thr Phe Asp Gly Lys 
        435                 440                 445             


Gln Tyr Thr Val His Gly Asp Cys Ser Tyr Val Leu Thr Lys Pro Cys 
    450                 455                 460                 


Asp Ser Ser Ala Phe Thr Val Leu Ala Glu Leu Arg Arg Cys Gly Leu 
465                 470                 475                 480 


Thr Asp Ser Glu Thr Cys Leu Lys Ser Val Thr Leu Ser Leu Asp Gly 
                485                 490                 495     


Ala Gln Thr Val Val Val Ile Lys Ala Ser Gly Glu Val Phe Leu Asn 
            500                 505                 510         


Gln Ile Tyr Thr Gln Leu Pro Ile Ser Ala Ala Asn Val Thr Ile Phe 
        515                 520                 525             


Arg Pro Ser Thr Phe Phe Ile Ile Ala Gln Thr Ser Leu Gly Leu Gln 
    530                 535                 540                 


Leu Asn Leu Gln Pro Val Pro Thr Met Gln Leu Phe Met Gln Leu Ala 
545                 550                 555                 560 


Pro Lys Leu Arg Gly Gln Thr Cys Gly Leu Cys Gly Asn Phe Asn Ser 
                565                 570                 575     


Ile Gln Ala Asp Asp Phe Arg Thr Leu Ser Gly Val Val Glu Ala Thr 
            580                 585                 590         


Ala Ala Ala Phe Phe Asn Thr Phe Lys Thr Gln Ala Ala Cys Pro Asn 
        595                 600                 605             


Ile Arg Asn Ser Phe Glu Asp Pro Cys Ser Leu Ser Val Glu Asn Glu 
    610                 615                 620                 


Lys Tyr Ala Gln His Trp Cys Ser Gln Leu Thr Asp Ala Asp Gly Pro 
625                 630                 635                 640 


Phe Gly Arg Cys His Ala Ala Val Lys Pro Gly Thr Tyr Tyr Ser Asn 
                645                 650                 655     


Cys Val Phe Asp Thr Cys Asn Cys Glu Arg Ser Glu Asp Cys Leu Cys 
            660                 665                 670         


Ala Ala Leu Ser Ser Tyr Val His Ala Cys Ala Ala Lys Gly Val Gln 
        675                 680                 685             


Leu Gly Gly Trp Arg Asp Gly Val Cys Thr Lys Pro Met Thr Thr Cys 
    690                 695                 700                 


Pro Lys Ser Met Thr Tyr His Tyr His Val Ser Thr Cys Gln Pro Thr 
705                 710                 715                 720 


Cys Arg Ser Leu Ser Glu Gly Asp Ile Thr Cys Ser Val Gly Phe Ile 
                725                 730                 735     


Pro Val Asp Gly Cys Ile Cys Pro Lys Gly Thr Phe Leu Asp Asp Thr 
            740                 745                 750         


Gly Lys Cys Val Gln Ala Ser Asn Cys Pro Cys Tyr His Arg Gly Ser 
        755                 760                 765             


Met Ile Pro Asn Gly Glu Ser Val His Asp Ser Gly Ala Ile Cys Thr 
    770                 775                 780                 


Cys Thr His Gly Lys Leu Ser Cys Ile Gly Gly Gln Ala Pro Ala Pro 
785                 790                 795                 800 


Val Cys Ala Ala Pro Met Val Phe Phe Asp Cys Arg Asn Ala Thr Pro 
                805                 810                 815     


Gly Asp Thr Gly Ala Gly Cys Gln Lys Ser Cys His Thr Leu Asp Met 
            820                 825                 830         


Thr Cys Tyr Ser Pro Gln Cys Val Pro Gly Cys Val Cys Pro Asp Gly 
        835                 840                 845             


Leu Val Ala Asp Gly Glu Gly Gly Cys Ile Thr Ala Glu Asp Cys Pro 
    850                 855                 860                 


Cys Val His Asn Glu Ala Ser Tyr Arg Ala Gly Gln Thr Ile Arg Val 
865                 870                 875                 880 


Gly Cys Asn Thr Cys Thr Cys Asp Ser Arg Met Trp Arg Cys Thr Asp 
                885                 890                 895     


Asp Pro Cys Leu Ala Thr Cys Ala Val Tyr Gly Asp Gly His Tyr Leu 
            900                 905                 910         


Thr Phe Asp Gly Gln Ser Tyr Ser Phe Asn Gly Asp Cys Glu Tyr Thr 
        915                 920                 925             


Leu Val Gln Asn His Cys Gly Gly Lys Asp Ser Thr Gln Asp Ser Phe 
    930                 935                 940                 


Arg Val Val Thr Glu Asn Val Pro Cys Gly Thr Thr Gly Thr Thr Cys 
945                 950                 955                 960 


Ser Lys Ala Ile Lys Ile Phe Leu Gly Gly Phe Glu Leu Lys Leu Ser 
                965                 970                 975     


His Gly Lys Val Glu Val Ile Gly Thr Asp Glu Ser Gln Glu Val Pro 
            980                 985                 990         


Tyr Thr Ile Gln Gln Met Gly Ile  Tyr Leu Val Val Asp  Thr Asp Ile 
        995                 1000                 1005             


Gly Leu  Val Leu Leu Trp Asp  Lys Lys Thr Ser Ile  Phe Ile Asn 
    1010                 1015                 1020             


Leu Ser  Pro Glu Phe Lys Gly  Arg Val Cys Gly Leu  Cys Gly Asn 
    1025                 1030                 1035             


Phe Asp  Asp Ile Ala Val Asn  Asp Phe Ala Thr Arg  Ser Arg Ser 
    1040                 1045                 1050             


Val Val  Gly Asp Val Leu Glu  Phe Gly Asn Ser Trp  Lys Leu Ser 
    1055                 1060                 1065             


Pro Ser  Cys Pro Asp Ala Leu  Ala Pro Lys Asp Pro  Cys Thr Ala 
    1070                 1075                 1080             


Asn Pro  Phe Arg Lys Ser Trp  Ala Gln Lys Gln Cys  Ser Ile Leu 
    1085                 1090                 1095             


His Gly  Pro Thr Phe Ala Ala  Cys His Ala His Val  Glu Pro Ala 
    1100                 1105                 1110             


Arg Tyr  Tyr Glu Ala Cys Val  Asn Asp Ala Cys Ala  Cys Asp Ser 
    1115                 1120                 1125             


Gly Gly  Asp Cys Glu Cys Phe  Cys Thr Ala Val Ala  Ala Tyr Ala 
    1130                 1135                 1140             


Gln Ala  Cys His Glu Val Gly  Leu Cys Val Cys Leu  Arg Thr Pro 
    1145                 1150                 1155             


Ser Ile  Cys Pro Leu Phe Cys  Asp Tyr Tyr Asn Pro  Glu Gly Gln 
    1160                 1165                 1170             


Cys Glu  Trp His Tyr Gln Pro  Cys Gly Val Pro Cys  Leu Arg Thr 
    1175                 1180                 1185             


Cys Arg  Asn Pro Arg Gly Asp  Cys Leu Arg Asp Val  Arg Gly Leu 
    1190                 1195                 1200             


Glu Gly  Cys Tyr Pro Lys Cys  Pro Pro Glu Ala Pro  Ile Phe Asp 
    1205                 1210                 1215             


Glu Asp  Lys Met Gln Cys Val  Ala Thr Cys Pro Thr  Pro Pro Leu 
    1220                 1225                 1230             


Pro Pro  Arg Cys His Val His  Gly Lys Ser Tyr Arg  Pro Gly Ala 
    1235                 1240                 1245             


Val Val  Pro Ser Asp Lys Asn  Cys Gln Ser Cys Leu  Cys Thr Glu 
    1250                 1255                 1260             


Arg Gly  Val Glu Cys Thr Tyr  Lys Ala Glu Ala Cys  Val Cys Thr 
    1265                 1270                 1275             


Tyr Asn  Gly Gln Arg Phe His  Pro Gly Asp Val Ile  Tyr His Thr 
    1280                 1285                 1290             


Thr Asp  Gly Thr Gly Gly Cys  Ile Ser Ala Arg Cys  Gly Ala Asn 
    1295                 1300                 1305             


Gly Thr  Ile Glu Arg Arg Val  Tyr Pro Cys Ser Pro  Thr Thr Pro 
    1310                 1315                 1320             


Val Pro  Pro Thr Thr Phe Ser  Phe Ser Thr Pro Pro  Leu Val Val 
    1325                 1330                 1335             


Ser Ser  Thr His Thr Pro Ser  Asn Gly Pro Ser Ser  Ala His Thr 
    1340                 1345                 1350             


Gly Pro  Pro Ser Ser Ala Trp  Pro Thr Thr Ala Gly  Thr Ser Pro 
    1355                 1360                 1365             


Arg Thr  Arg Leu Pro Thr Ala  Ser Ala Ser Leu Pro  Pro Val Cys 
    1370                 1375                 1380             


Gly Glu  Lys Cys Leu Trp Ser  Pro Trp Met Asp Val  Ser Arg Pro 
    1385                 1390                 1395             


Gly Arg  Gly Thr Asp Ser Gly  Asp Phe Asp Thr Leu  Glu Asn Leu 
    1400                 1405                 1410             


Arg Ala  His Gly Tyr Arg Val  Cys Glu Ser Pro Arg  Ser Val Glu 
    1415                 1420                 1425             


Cys Arg  Ala Glu Asp Ala Pro  Gly Val Pro Leu Arg  Ala Leu Gly 
    1430                 1435                 1440             


Gln Arg  Val Gln Cys Ser Pro  Asp Val Gly Leu Thr  Cys Arg Asn 
    1445                 1450                 1455             


Arg Glu  Gln Ala Ser Gly Leu  Cys Tyr Asn Tyr Gln  Ile Arg Val 
    1460                 1465                 1470             


Gln Cys  Cys Thr Pro Leu Pro  Cys Ser Thr Ser Ser  Ser Pro Ala 
    1475                 1480                 1485             


Gln Thr  Thr Pro Pro Thr Thr  Ser Lys Thr Thr Glu  Thr Arg Ala 
    1490                 1495                 1500             


Ser Gly  Ser Ser Ala Pro Ser  Ser Thr Pro Gly Thr  Val Ser Leu 
    1505                 1510                 1515             


Ser Thr  Ala Arg Thr Thr Pro  Ala Pro Gly Thr Ala  Thr Ser Val 
    1520                 1525                 1530             


Lys Lys  Thr Phe Ser Thr Pro  Ser Pro Pro Pro Val  Pro Ala Thr 
    1535                 1540                 1545             


Ser Thr  Ser Ser Met Ser Thr  Thr Ala Pro Gly Thr  Ser Val Val 
    1550                 1555                 1560             


Ser Ser  Lys Pro Thr Pro Thr  Glu Pro Ser Thr Ser  Ser Cys Leu 
    1565                 1570                 1575             


Gln Glu  Leu Cys Thr Trp Thr  Glu Trp Ile Asp Gly  Ser Tyr Pro 
    1580                 1585                 1590             


Ala Pro  Gly Ile Asn Gly Gly  Asp Phe Asp Thr Phe  Gln Asn Leu 
    1595                 1600                 1605             


Arg Asp  Glu Gly Tyr Thr Phe  Cys Glu Ser Pro Arg  Ser Val Gln 
    1610                 1615                 1620             


Cys Arg  Ala Glu Ser Phe Pro  Asn Thr Pro Leu Ala  Asp Leu Gly 
    1625                 1630                 1635             


Gln Asp  Val Ile Cys Ser His  Thr Glu Gly Leu Ile  Cys Leu Asn 
    1640                 1645                 1650             


Lys Asn  Gln Leu Pro Pro Ile  Cys Tyr Asn Tyr Glu  Ile Arg Ile 
    1655                 1660                 1665             


Gln Cys  Cys Glu Thr Val Asn  Val Cys Arg Asp Ile  Thr Arg Leu 
    1670                 1675                 1680             


Pro Lys  Thr Val Ala Thr Thr  Arg Pro Thr Pro His  Pro Thr Gly 
    1685                 1690                 1695             


Ala Gln  Thr Gln Thr Thr Phe  Thr Thr His Met Pro  Ser Ala Ser 
    1700                 1705                 1710             


Thr Glu  Gln Pro Thr Ala Thr  Ser Arg Gly Gly Pro  Thr Ala Thr 
    1715                 1720                 1725             


Ser Val  Thr Gln Gly Thr His  Thr Thr Leu Val Thr  Arg Asn Cys 
    1730                 1735                 1740             


His Pro  Arg Cys Thr Trp Thr  Lys Trp Phe Asp Val  Asp Phe Pro 
    1745                 1750                 1755             


Ser Pro  Gly Pro His Gly Gly  Asp Lys Glu Thr Tyr  Asn Asn Ile 
    1760                 1765                 1770             


Ile Arg  Ser Gly Glu Lys Ile  Cys Arg Arg Pro Glu  Glu Ile Thr 
    1775                 1780                 1785             


Arg Val  Gln Cys Arg Ala Lys  Ser His Pro Glu Val  Ser Ile Glu 
    1790                 1795                 1800             


His Leu  Gly Gln Val Val Gln  Cys Ser Arg Glu Glu  Gly Leu Val 
    1805                 1810                 1815             


Cys Arg  Asn Gln Asp Gln Gln  Gly Pro Phe Lys Met  Cys Leu Asn 
    1820                 1825                 1830             


Tyr Glu  Val Arg Val Leu Cys  Cys Glu Thr Pro Arg  Gly Cys His 
    1835                 1840                 1845             


Met Thr  Ser Thr Pro Gly Ser  Thr Ser Ser Ser Pro  Ala Gln Thr 
    1850                 1855                 1860             


Thr Pro  Ser Thr Thr Ser Lys  Thr Thr Glu Ile Gln  Ala Ser Gly 
    1865                 1870                 1875             


Ser Ser  Ala Pro Ser Ser Thr  Pro Gly Thr Val Ser  Leu Ser Thr 
    1880                 1885                 1890             


Ala Arg  Thr Thr Pro Ala Pro  Gly Thr Ala Thr Ser  Val Lys Lys 
    1895                 1900                 1905             


Thr Phe  Ser Thr Pro Ser Pro  Pro Pro Val Pro Ala  Thr Ser Thr 
    1910                 1915                 1920             


Ser Ser  Met Ser Thr Thr Ala  Pro Gly Thr Ser Val  Val Ser Ser 
    1925                 1930                 1935             


Lys Pro  Thr Pro Thr Glu Pro  Ser Thr Ser Ser Cys  Leu Gln Glu 
    1940                 1945                 1950             


Leu Cys  Thr Trp Thr Glu Trp  Ile Asp Gly Ser Tyr  Pro Ala Pro 
    1955                 1960                 1965             


Gly Ile  Asn Gly Gly Asp Phe  Asp Thr Phe Gln Asn  Leu Arg Asp 
    1970                 1975                 1980             


Glu Gly  Tyr Thr Phe Cys Glu  Ser Pro Arg Ser Val  Gln Cys Arg 
    1985                 1990                 1995             


Ala Glu  Ser Phe Pro Asn Thr  Pro Leu Gly Arg Leu  Gly Gln Asp 
    2000                 2005                 2010             


Val Ile  Cys Ser His Thr Glu  Gly Leu Ile Cys Leu  Asn Lys Asn 
    2015                 2020                 2025             


Gln Leu  Pro Pro Ile Cys Tyr  Asn Tyr Glu Ile Arg  Ile Gln Cys 
    2030                 2035                 2040             


Cys Glu  Thr Val Asn Val Cys  Arg Asp Ile Thr Arg  Pro Pro Lys 
    2045                 2050                 2055             


Thr Val  Ala Thr Thr Arg Pro  Thr Pro His Pro Thr  Gly Ala Gln 
    2060                 2065                 2070             


Thr Gln  Thr Thr Phe Thr Thr  His Met Pro Ser Ala  Ser Thr Glu 
    2075                 2080                 2085             


Gln Pro  Thr Ala Thr Ser Arg  Gly Gly Pro Thr Ala  Thr Ser Val 
    2090                 2095                 2100             


Thr Gln  Gly Thr His Thr Thr  Pro Val Thr Arg Asn  Cys His Pro 
    2105                 2110                 2115             


Arg Cys  Thr Trp Thr Thr Trp  Phe Asp Val Asp Phe  Pro Ser Pro 
    2120                 2125                 2130             


Gly Pro  His Gly Gly Asp Lys  Glu Thr Tyr Asn Asn  Ile Ile Arg 
    2135                 2140                 2145             


Ser Gly  Glu Lys Ile Cys Arg  Arg Pro Glu Glu Ile  Thr Arg Leu 
    2150                 2155                 2160             


Gln Cys  Arg Ala Lys Ser His  Pro Glu Val Ser Ile  Glu His Leu 
    2165                 2170                 2175             


Gly Gln  Val Val Gln Cys Ser  Arg Glu Glu Gly Leu  Val Cys Arg 
    2180                 2185                 2190             


Asn Gln  Asp Gln Gln Gly Pro  Phe Lys Met Cys Leu  Asn Ile Glu 
    2195                 2200                 2205             


Val Arg  Val Leu Cys Cys Glu  Thr Pro Lys Gly Cys  Pro Val Thr 
    2210                 2215                 2220             


Ser Thr  Pro Val Thr Ala Pro  Ser Thr Pro Ser Gly  Arg Ala Ile 
    2225                 2230                 2235             


Ser Pro  Thr Gln Ser Thr Ser  Ser Trp Gln Lys Ser  Arg Thr Thr 
    2240                 2245                 2250             


Thr Leu  Val Thr Thr Ser Thr  Thr Ser Thr Pro Gln  Thr Ser Thr 
    2255                 2260                 2265             


Thr Tyr  Ala His Thr Thr Ser  Thr Thr Ser Ala Pro  Thr Ala Arg 
    2270                 2275                 2280             


Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Thr Ser Val  Pro Thr Thr 
    2285                 2290                 2295             


Ser Thr  Ile Ser Gly Pro Lys  Thr Thr Pro Ser Pro  Val Pro Thr 
    2300                 2305                 2310             


Thr Ser  Thr Thr Ser Ala Ala  Thr Thr Ser Thr Ile  Ser Ala Pro 
    2315                 2320                 2325             


Thr Thr  Ser Thr Thr Ser Val  Pro Gly Thr Thr Pro  Ser Pro Val 
    2330                 2335                 2340             


Leu Thr  Thr Ser Thr Thr Ser  Ala Pro Thr Thr Arg  Thr Thr Ser 
    2345                 2350                 2355             


Ala Ser  Pro Ala Gly Thr Thr  Ser Gly Pro Gly Asn  Thr Pro Ser 
    2360                 2365                 2370             


Pro Val  Pro Thr Thr Ser Thr  Ile Ser Ala Pro Thr  Thr Ser Ile 
    2375                 2380                 2385             


Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser Ala Pro  Thr Ser Ser 
    2390                 2395                 2400             


Thr Thr  Ser Gly Pro Gly Thr  Thr Pro Ser Pro Val  Pro Thr Thr 
    2405                 2410                 2415             


Ser Ile  Thr Ser Ala Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Thr 
    2420                 2425                 2430             


Thr Ser  Thr Thr Ser Ala Pro  Thr Thr Ser Thr Thr  Ser Ala Pro 
    2435                 2440                 2445             


Thr Thr  Ser Thr Thr Ser Ala  Pro Thr Thr Ser Thr  Thr Ser Thr 
    2450                 2455                 2460             


Pro Thr  Ser Ser Thr Thr Ser  Thr Pro Gln Thr Ser  Thr Thr Ser 
    2465                 2470                 2475             


Ala Ser  Thr Thr Ser Ile Thr  Ser Gly Pro Gly Thr  Thr Pro Ser 
    2480                 2485                 2490             


Pro Val  Pro Thr Thr Ser Thr  Thr Ser Ala Pro Thr  Thr Ser Thr 
    2495                 2500                 2505             


Thr Ser  Ala Ala Thr Thr Ser  Thr Ile Ser Ala Pro  Thr Thr Ser 
    2510                 2515                 2520             


Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Thr Ser Ala  Ser Thr Ala 
    2525                 2530                 2535             


Ser Lys  Thr Ser Gly Leu Gly  Thr Thr Pro Ser Pro  Ile Pro Thr 
    2540                 2545                 2550             


Thr Ser  Thr Thr Ser Pro Pro  Thr Thr Ser Thr Thr  Ser Ala Ser 
    2555                 2560                 2565             


Thr Ala  Ser Lys Thr Ser Gly  Pro Gly Thr Thr Pro  Ser Pro Val 
    2570                 2575                 2580             


Pro Thr  Thr Ser Thr Ile Phe  Ala Pro Arg Thr Ser  Thr Thr Ser 
    2585                 2590                 2595             


Ala Ser  Thr Thr Ser Thr Thr  Pro Gly Pro Gly Thr  Thr Pro Ser 
    2600                 2605                 2610             


Pro Val  Pro Thr Thr Ser Thr  Ala Ser Val Ser Lys  Thr Ser Thr 
    2615                 2620                 2625             


Ser His  Val Ser Ile Ser Lys  Thr Thr His Ser Gln  Pro Val Thr 
    2630                 2635                 2640             


Arg Asp  Cys His Leu Arg Cys  Thr Trp Thr Lys Trp  Phe Asp Val 
    2645                 2650                 2655             


Asp Phe  Pro Ser Pro Gly Pro  His Gly Gly Asp Lys  Glu Thr Tyr 
    2660                 2665                 2670             


Asn Asn  Ile Ile Arg Ser Gly  Glu Lys Ile Cys Arg  Arg Pro Glu 
    2675                 2680                 2685             


Glu Ile  Thr Arg Leu Gln Cys  Arg Ala Glu Ser His  Pro Glu Val 
    2690                 2695                 2700             


Ser Ile  Glu His Leu Gly Gln  Val Val Gln Cys Ser  Arg Glu Glu 
    2705                 2710                 2715             


Gly Leu  Val Cys Arg Asn Gln  Asp Gln Gln Gly Pro  Phe Lys Met 
    2720                 2725                 2730             


Cys Leu  Asn Tyr Glu Val Arg  Val Leu Cys Cys Glu  Thr Pro Lys 
    2735                 2740                 2745             


Gly Cys  Pro Val Thr Ser Thr  Pro Val Thr Ala Pro  Ser Thr Pro 
    2750                 2755                 2760             


Ser Gly  Arg Ala Thr Ser Pro  Thr Gln Ser Thr Ser  Ser Trp Gln 
    2765                 2770                 2775             


Lys Ser  Arg Thr Thr Thr Leu  Val Thr Thr Ser Thr  Thr Ser Thr 
    2780                 2785                 2790             


Pro Gln  Thr Ser Thr Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser 
    2795                 2800                 2805             


Ala Pro  Thr Thr Ser Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Thr 
    2810                 2815                 2820             


Ser Thr  Pro Gln Thr Ser Ile  Ser Ser Ala Pro Thr  Ser Ser Thr 
    2825                 2830                 2835             


Thr Ser  Ala Pro Thr Ser Ser  Thr Ile Ser Ala Arg  Thr Thr Ser 
    2840                 2845                 2850             


Ile Ile  Ser Ala Pro Thr Thr  Ser Thr Thr Ser Ser  Pro Thr Thr 
    2855                 2860                 2865             


Ser Thr  Thr Ser Ala Thr Thr  Thr Ser Thr Thr Ser  Ala Pro Thr 
    2870                 2875                 2880             


Ser Ser  Thr Thr Ser Thr Pro  Gln Thr Ser Lys Thr  Ser Ala Ala 
    2885                 2890                 2895             


Thr Ser  Ser Thr Thr Ser Ser  Ser Gly Thr Thr Pro  Ser Pro Val 
    2900                 2905                 2910             


Thr Thr  Thr Ser Thr Ala Ser  Val Ser Lys Thr Ser  Thr Ser His 
    2915                 2920                 2925             


Val Ser  Val Ser Lys Thr Thr  His Ser Gln Pro Val  Thr Arg Asp 
    2930                 2935                 2940             


Cys His  Pro Arg Cys Thr Trp  Thr Lys Trp Phe Asp  Val Asp Phe 
    2945                 2950                 2955             


Pro Ser  Pro Gly Pro His Gly  Gly Asp Lys Glu Thr  Tyr Asn Asn 
    2960                 2965                 2970             


Ile Ile  Arg Ser Gly Glu Lys  Ile Cys Arg Arg Pro  Gln Glu Ile 
    2975                 2980                 2985             


Thr Arg  Leu Gln Cys Arg Ala  Lys Ser His Pro Glu  Val Ser Ile 
    2990                 2995                 3000             


Glu His  Leu Gly Gln Val Val  Gln Cys Ser Arg Glu  Glu Gly Leu 
    3005                 3010                 3015             


Val Cys  Arg Asn Gln Asp Gln  Gln Gly Pro Phe Lys  Met Cys Leu 
    3020                 3025                 3030             


Asn Tyr  Glu Val Arg Val Leu  Cys Cys Glu Thr Pro  Lys Gly Cys 
    3035                 3040                 3045             


Pro Val  Thr Ser Thr Ser Val  Thr Ala Pro Ser Pro  Leu Val Gly 
    3050                 3055                 3060             


Glu Pro  Pro Ala Gln Thr Gln  Ser Thr Ser Ser Trp  Gln Lys Ser 
    3065                 3070                 3075             


Arg Thr  Thr Thr Leu Val Thr  Ser Ser Ile Thr Ser  Thr Thr Gln 
    3080                 3085                 3090             


Thr Ser  Thr Thr Ser Ala Pro  Thr Thr Ser Thr Thr  Pro Ala Ser 
    3095                 3100                 3105             


Ile Pro  Ser Thr Thr Ser Ala  Pro Thr Thr Ser Thr  Thr Ser Ala 
    3110                 3115                 3120             


Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser 
    3125                 3130                 3135             


Thr Pro  Gln Thr Thr Thr Ser  Ser Ala Pro Thr Ser  Ser Thr Thr 
    3140                 3145                 3150             


Ser Ala  Pro Thr Thr Ser Thr  Ile Ser Ala Pro Thr  Thr Ser Thr 
    3155                 3160                 3165             


Ile Ser  Ala Pro Thr Thr Ser  Thr Thr Ser Ala Pro  Thr Ala Ser 
    3170                 3175                 3180             


Thr Thr  Ser Ala Pro Thr Ser  Thr Ser Ser Ala Pro  Thr Thr Asn 
    3185                 3190                 3195             


Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Thr Ser Ala  Pro Ile Thr 
    3200                 3205                 3210             


Ser Thr  Ile Ser Ala Pro Thr  Thr Ser Thr Thr Ser  Thr Pro Gln 
    3215                 3220                 3225             


Thr Ser  Thr Ile Ser Ser Pro  Thr Thr Ser Thr Thr  Pro Thr Pro 
    3230                 3235                 3240             


Gln Thr  Ser Thr Thr Ser Ser  Pro Thr Thr Ser Thr  Thr Ser Ala 
    3245                 3250                 3255             


Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser 
    3260                 3265                 3270             


Thr Pro  Gln Thr Ser Ile Ser  Ser Ala Pro Thr Ser  Ser Thr Thr 
    3275                 3280                 3285             


Ser Ala  Pro Thr Ala Ser Thr  Ile Ser Ala Pro Thr  Thr Ser Thr 
    3290                 3295                 3300             


Thr Ser  Phe His Thr Thr Ser  Thr Thr Ser Pro Pro  Thr Ser Ser 
    3305                 3310                 3315             


Thr Ser  Ser Thr Pro Gln Thr  Ser Lys Thr Ser Ala  Ala Thr Ser 
    3320                 3325                 3330             


Ser Thr  Thr Ser Gly Ser Gly  Thr Thr Pro Ser Pro  Val Pro Thr 
    3335                 3340                 3345             


Thr Ser  Thr Ala Ser Val Ser  Lys Thr Ser Thr Ser  His Val Ser 
    3350                 3355                 3360             


Val Ser  Lys Thr Thr His Ser  Gln Pro Val Thr Arg  Asp Cys His 
    3365                 3370                 3375             


Pro Arg  Cys Thr Trp Thr Lys  Trp Phe Asp Val Asp  Phe Pro Ser 
    3380                 3385                 3390             


Pro Gly  Pro His Gly Gly Asp  Lys Glu Thr Tyr Asn  Asn Ile Ile 
    3395                 3400                 3405             


Arg Ser  Gly Glu Lys Ile Cys  Arg Arg Pro Glu Glu  Ile Thr Arg 
    3410                 3415                 3420             


Leu Gln  Cys Arg Ala Glu Ser  His Pro Glu Val Ser  Ile Glu His 
    3425                 3430                 3435             


Leu Gly  Gln Val Val Gln Cys  Ser Arg Glu Glu Gly  Leu Val Cys 
    3440                 3445                 3450             


Arg Asn  Gln Asp Gln Gln Gly  Pro Phe Lys Met Cys  Leu Asn Tyr 
    3455                 3460                 3465             


Glu Val  Arg Val Leu Cys Cys  Glu Thr Pro Lys Gly  Cys Pro Val 
    3470                 3475                 3480             


Thr Ser  Thr Pro Val Thr Ala  Pro Ser Thr Pro Ser  Gly Arg Ala 
    3485                 3490                 3495             


Thr Ser  Pro Thr Gln Ser Thr  Ser Ser Trp Gln Lys  Ser Arg Thr 
    3500                 3505                 3510             


Thr Thr  Leu Val Thr Thr Ser  Thr Thr Ser Thr Pro  Gln Thr Ser 
    3515                 3520                 3525             


Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Ile Pro Ala  Ser Thr Pro 
    3530                 3535                 3540             


Ser Thr  Thr Ser Ala Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Thr 
    3545                 3550                 3555             


Thr Ser  Thr Thr Ser Ala Pro  Thr His Arg Thr Thr  Ser Gly Pro 
    3560                 3565                 3570             


Thr Thr  Ser Thr Thr Leu Ala  Pro Thr Thr Ser Thr  Thr Ser Ala 
    3575                 3580                 3585             


Pro Thr  Thr Ser Thr Asn Ser  Ala Pro Thr Thr Ser  Thr Ile Ser 
    3590                 3595                 3600             


Ala Ser  Thr Thr Ser Thr Ile  Ser Ala Pro Thr Thr  Ser Thr Ile 
    3605                 3610                 3615             


Ser Ser  Pro Thr Ser Ser Thr  Thr Ser Thr Pro Gln  Thr Ser Lys 
    3620                 3625                 3630             


Thr Ser  Ala Ala Thr Ser Ser  Thr Thr Ser Gly Ser  Gly Thr Thr 
    3635                 3640                 3645             


Pro Ser  Pro Val Pro Thr Thr  Ser Thr Thr Ser Ala  Ser Thr Thr 
    3650                 3655                 3660             


Ser Thr  Thr Ser Ala Pro Thr  Thr Ser Thr Thr Ser  Gly Pro Gly 
    3665                 3670                 3675             


Thr Thr  Pro Ser Pro Val Pro  Ser Thr Ser Ile Thr  Ser Ala Ala 
    3680                 3685                 3690             


Thr Thr  Ser Thr Thr Ser Ala  Pro Thr Thr Arg Thr  Thr Ser Ala 
    3695                 3700                 3705             


Pro Thr  Ser Ser Met Thr Ser  Gly Pro Gly Thr Thr  Pro Ser Pro 
    3710                 3715                 3720             


Val Pro  Thr Thr Ser Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Thr 
    3725                 3730                 3735             


Ser Gly  Pro Gly Thr Thr Pro  Ser Pro Val Pro Thr  Thr Ser Thr 
    3740                 3745                 3750             


Thr Ser  Ala Pro Ile Thr Ser  Thr Thr Ser Gly Pro  Gly Ser Thr 
    3755                 3760                 3765             


Pro Ser  Pro Val Pro Thr Thr  Ser Thr Thr Ser Ala  Pro Thr Thr 
    3770                 3775                 3780             


Ser Thr  Thr Ser Ala Ser Thr  Ala Ser Thr Thr Ser  Gly Pro Thr 
    3785                 3790                 3795             


Thr Ser  Thr Thr Ser Ala Ser  Thr Thr Ser Thr Ile  Ser Pro Leu 
    3800                 3805                 3810             


Thr Thr  Ser Thr Thr Ser Ala  Pro Ile Thr Ser Met  Pro Ser Gly 
    3815                 3820                 3825             


Pro Gly  Thr Thr Pro Ser Pro  Val Pro Thr Thr Ser  Thr Thr Ser 
    3830                 3835                 3840             


Ala Pro  Thr Thr Ser Thr Thr  Ser Gly Pro Gly Thr  Thr Pro Ser 
    3845                 3850                 3855             


Pro Val  Pro Thr Thr Ser Thr  Thr Ser Ala Pro Thr  Thr Ser Thr 
    3860                 3865                 3870             


Thr Ser  Ala Ser Thr Ala Ser  Thr Thr Ser Gly Pro  Gly Thr Thr 
    3875                 3880                 3885             


Pro Ser  Pro Val Pro Thr Thr  Ser Thr Thr Ser Ala  Pro Thr Thr 
    3890                 3895                 3900             


Ser Thr  Thr Ser Ala Ser Thr  Ala Ser Thr Thr Ser  Gly Pro Gly 
    3905                 3910                 3915             


Thr Ser  Leu Ser Pro Val Pro  Thr Thr Ser Thr Thr  Ser Ala Pro 
    3920                 3925                 3930             


Thr Thr  Ser Thr Thr Ser Gly  Pro Gly Thr Thr Pro  Ser Pro Val 
    3935                 3940                 3945             


Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser 
    3950                 3955                 3960             


Gly Pro  Gly Thr Thr Pro Ser  Pro Val Pro Thr Thr  Ser Thr Thr 
    3965                 3970                 3975             


Pro Val  Ser Lys Thr Ser Thr  Ser His Leu Ser Val  Ser Lys Thr 
    3980                 3985                 3990             


Thr His  Ser Gln Pro Val Thr  Ser Asp Cys His Pro  Leu Cys Ala 
    3995                 4000                 4005             


Trp Thr  Lys Trp Phe Asp Val  Asp Phe Pro Ser Pro  Gly Pro His 
    4010                 4015                 4020             


Gly Gly  Asp Lys Glu Thr Tyr  Asn Asn Ile Ile Arg  Ser Gly Glu 
    4025                 4030                 4035             


Lys Ile  Cys Arg Arg Pro Glu  Glu Ile Thr Arg Leu  Gln Cys Arg 
    4040                 4045                 4050             


Ala Glu  Ser His Pro Glu Val  Asn Ile Glu His Leu  Gly Gln Val 
    4055                 4060                 4065             


Val Gln  Cys Ser Arg Glu Glu  Gly Leu Val Cys Arg  Asn Gln Asp 
    4070                 4075                 4080             


Gln Gln  Gly Pro Phe Lys Met  Cys Leu Asn Tyr Glu  Val Arg Val 
    4085                 4090                 4095             


Leu Cys  Cys Glu Thr Pro Arg  Gly Cys Pro Val Thr  Ser Val Thr 
    4100                 4105                 4110             


Pro Tyr  Gly Thr Ser Pro Thr  Asn Ala Leu Tyr Pro  Ser Leu Ser 
    4115                 4120                 4125             


Thr Ser  Met Val Ser Ala Ser  Val Ala Ser Thr Ser  Val Ala Ser 
    4130                 4135                 4140             


Ser Ser  Val Ala Ser Ser Ser  Val Ala Tyr Ser Thr  Gln Thr Cys 
    4145                 4150                 4155             


Phe Cys  Asn Val Ala Asp Arg  Leu Tyr Pro Ala Gly  Ser Thr Ile 
    4160                 4165                 4170             


Tyr Arg  His Arg Asp Leu Ala  Gly His Cys Tyr Tyr  Ala Leu Cys 
    4175                 4180                 4185             


Ser Gln  Asp Cys Gln Val Val  Arg Gly Val Asp Ser  Asp Cys Pro 
    4190                 4195                 4200             


Ser Thr  Thr Leu Pro Pro Ala  Pro Ala Thr Ser Pro  Ser Ile Ser 
    4205                 4210                 4215             


Thr Ser  Glu Pro Val Thr Glu  Leu Gly Cys Pro Asn  Ala Val Pro 
    4220                 4225                 4230             


Pro Arg  Lys Lys Gly Glu Thr  Trp Ala Thr Pro Asn  Cys Ser Glu 
    4235                 4240                 4245             


Ala Thr  Cys Glu Gly Asn Asn  Val Ile Ser Leu Ser  Pro Arg Thr 
    4250                 4255                 4260             


Cys Pro  Arg Val Glu Lys Pro  Thr Cys Ala Asn Gly  Tyr Pro Ala 
    4265                 4270                 4275             


Val Lys  Val Ala Asp Gln Asp  Gly Cys Cys His His  Tyr Gln Cys 
    4280                 4285                 4290             


Gln Cys  Val Cys Ser Gly Trp  Gly Asp Pro His Tyr  Ile Thr Phe 
    4295                 4300                 4305             


Asp Gly  Thr Tyr Tyr Thr Phe  Leu Asp Asn Cys Thr  Tyr Val Leu 
    4310                 4315                 4320             


Val Gln  Gln Ile Val Pro Val  Tyr Gly His Phe Arg  Val Leu Val 
    4325                 4330                 4335             


Asp Asn  Tyr Phe Cys Gly Ala  Glu Asp Gly Leu Ser  Cys Pro Arg 
    4340                 4345                 4350             


Ser Ile  Ile Leu Glu Tyr His  Gln Asp Arg Val Val  Leu Thr Arg 
    4355                 4360                 4365             


Lys Pro  Val His Gly Val Met  Thr Asn Glu Ile Ile  Phe Asn Asn 
    4370                 4375                 4380             


Lys Val  Val Ser Pro Gly Phe  Arg Lys Asn Gly Ile  Val Val Ser 
    4385                 4390                 4395             


Arg Ile  Gly Val Lys Met Tyr  Ala Thr Ile Pro Glu  Leu Gly Val 
    4400                 4405                 4410             


Gln Val  Met Phe Ser Gly Leu  Ile Phe Ser Val Glu  Val Pro Phe 
    4415                 4420                 4425             


Ser Lys  Phe Ala Asn Asn Thr  Glu Gly Gln Cys Gly  Thr Cys Thr 
    4430                 4435                 4440             


Asn Asp  Arg Lys Asp Glu Cys  Arg Thr Pro Arg Gly  Thr Val Val 
    4445                 4450                 4455             


Ala Ser  Cys Ser Glu Met Ser  Gly Leu Trp Asn Val  Ser Ile Pro 
    4460                 4465                 4470             


Asp Gln  Pro Ala Cys His Arg  Pro His Pro Thr Pro  Thr Thr Val 
    4475                 4480                 4485             


Gly Pro  Thr Thr Val Gly Ser  Thr Thr Val Gly Pro  Thr Thr Val 
    4490                 4495                 4500             


Gly Ser  Thr Thr Val Gly Pro  Thr Thr Pro Pro Ala  Pro Cys Leu 
    4505                 4510                 4515             


Pro Ser  Pro Ile Cys His Leu  Ile Leu Ser Lys Val  Phe Glu Pro 
    4520                 4525                 4530             


Cys His  Thr Val Ile Pro Pro  Leu Leu Phe Tyr Glu  Gly Cys Val 
    4535                 4540                 4545             


Phe Asp  Arg Cys His Met Thr  Asp Leu Asp Val Val  Cys Ser Ser 
    4550                 4555                 4560             


Leu Glu  Leu Tyr Ala Ala Leu  Cys Ala Ser His Asp  Ile Cys Ile 
    4565                 4570                 4575             


Asp Trp  Arg Gly Arg Thr Gly  His Met Cys Pro Phe  Thr Cys Pro 
    4580                 4585                 4590             


Ala Asp  Lys Val Tyr Gln Pro  Cys Gly Pro Ser Asn  Pro Ser Tyr 
    4595                 4600                 4605             


Cys Tyr  Gly Asn Asp Ser Ala  Ser Leu Gly Ala Leu  Arg Glu Ala 
    4610                 4615                 4620             


Gly Pro  Ile Thr Glu Gly Cys  Phe Cys Pro Glu Gly  Met Thr Leu 
    4625                 4630                 4635             


Phe Ser  Thr Ser Ala Gln Val  Cys Val Pro Thr Gly  Cys Pro Arg 
    4640                 4645                 4650             


Cys Leu  Gly Pro His Gly Glu  Pro Val Lys Val Gly  His Thr Val 
    4655                 4660                 4665             


Gly Met  Asp Cys Gln Glu Cys  Thr Cys Glu Ala Ala  Thr Trp Thr 
    4670                 4675                 4680             


Leu Thr  Cys Arg Pro Lys Leu  Cys Pro Leu Pro Pro  Ala Cys Pro 
    4685                 4690                 4695             


Leu Pro  Gly Phe Val Pro Val  Pro Ala Ala Pro Gln  Ala Gly Gln 
    4700                 4705                 4710             


Cys Cys  Pro Gln Tyr Ser Cys  Ala Cys Asn Thr Ser  Arg Cys Pro 
    4715                 4720                 4725             


Ala Pro  Val Gly Cys Pro Glu  Gly Ala Arg Ala Ile  Pro Thr Tyr 
    4730                 4735                 4740             


Gln Glu  Gly Ala Cys Cys Pro  Val Gln Asn Cys Ser  Trp Thr Val 
    4745                 4750                 4755             


Cys Ser  Ile Asn Gly Thr Leu  Tyr Gln Pro Gly Ala  Val Val Ser 
    4760                 4765                 4770             


Ser Ser  Leu Cys Glu Thr Cys  Arg Cys Glu Leu Pro  Gly Gly Pro 
    4775                 4780                 4785             


Pro Ser  Asp Ala Phe Val Val  Ser Cys Glu Thr Gln  Ile Cys Asn 
    4790                 4795                 4800             


Thr His  Cys Pro Val Gly Phe  Glu Tyr Gln Glu Gln  Ser Gly Gln 
    4805                 4810                 4815             


Cys Cys  Gly Thr Cys Val Gln  Val Ala Cys Val Thr  Asn Thr Ser 
    4820                 4825                 4830             


Lys Ser  Pro Ala His Leu Phe  Tyr Pro Gly Glu Thr  Trp Ser Asp 
    4835                 4840                 4845             


Ala Gly  Asn His Cys Val Thr  His Gln Cys Glu Lys  His Gln Asp 
    4850                 4855                 4860             


Gly Leu  Val Val Val Thr Thr  Lys Lys Ala Cys Pro  Pro Leu Ser 
    4865                 4870                 4875             


Cys Ser  Leu Asp Glu Ala Arg  Met Ser Lys Asp Gly  Cys Cys Arg 
    4880                 4885                 4890             


Phe Cys  Pro Leu Pro Pro Pro  Pro Tyr Gln Asn Gln  Ser Thr Cys 
    4895                 4900                 4905             


Ala Val  Tyr His Arg Ser Leu  Ile Ile Gln Gln Gln  Gly Cys Ser 
    4910                 4915                 4920             


Ser Ser  Glu Pro Val Arg Leu  Ala Tyr Cys Arg Gly  Asn Cys Gly 
    4925                 4930                 4935             


Asp Ser  Ser Ser Met Tyr Ser  Leu Glu Gly Asn Thr  Val Glu His 
    4940                 4945                 4950             


Arg Cys  Gln Cys Cys Gln Glu  Leu Arg Thr Ser Leu  Arg Asn Val 
    4955                 4960                 4965             


Thr Leu  His Cys Thr Asp Gly  Ser Ser Arg Ala Phe  Ser Tyr Thr 
    4970                 4975                 4980             


Glu Val  Glu Glu Cys Gly Cys  Met Gly Arg Arg Cys  Pro Ala Pro 
    4985                 4990                 4995             


Gly Asp  Thr Gln His Ser Glu  Glu Ala Glu Pro Glu  Pro Ser Gln 
    5000                 5005                 5010             


Glu Ala  Glu Ser Gly Ser Trp  Glu Arg Gly Val Pro  Val Ser Pro 
    5015                 5020                 5025             


Met His  
    5030 


<210>  69
<211>  1093
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Lys Glu Met Val Gly Gly Cys Cys Val Cys Ser Asp Glu Arg Gly 
1               5                   10                  15      


Trp Ala Glu Asn Pro Leu Val Tyr Cys Asp Gly His Ala Cys Ser Val 
            20                  25                  30          


Val Val His Gln Ala Cys Tyr Gly Ile Val Gln Val Pro Thr Gly Pro 
        35                  40                  45              


Trp Phe Cys Arg Lys Cys Glu Ser Gln Glu Arg Ala Ala Arg Val Arg 
    50                  55                  60                  


Cys Glu Leu Cys Pro His Lys Asp Gly Ala Leu Lys Arg Thr Asp Asn 
65                  70                  75                  80  


Gly Gly Trp Ala His Val Val Cys Ala Leu Tyr Ile Pro Glu Val Gln 
                85                  90                  95      


Phe Ala Asn Val Leu Thr Met Glu Pro Ile Val Leu Gln Tyr Val Pro 
            100                 105                 110         


His Asp Arg Phe Asn Lys Thr Cys Tyr Ile Cys Glu Glu Gln Gly Arg 
        115                 120                 125             


Glu Ser Lys Ala Ala Ser Gly Ala Cys Met Thr Cys Asn Arg His Gly 
    130                 135                 140                 


Cys Arg Gln Ala Phe His Val Thr Cys Ala Gln Met Ala Gly Leu Leu 
145                 150                 155                 160 


Cys Glu Glu Glu Val Leu Glu Val Asp Asn Val Lys Tyr Cys Gly Tyr 
                165                 170                 175     


Cys Lys Tyr His Phe Ser Lys Met Lys Thr Ser Arg His Ser Ser Gly 
            180                 185                 190         


Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Gly Ser Met Gly Gly Gly 
        195                 200                 205             


Gly Ser Gly Phe Ile Ser Gly Arg Arg Ser Arg Ser Ala Ser Pro Ser 
    210                 215                 220                 


Thr Gln Gln Glu Lys His Pro Thr His His Glu Arg Gly Gln Lys Lys 
225                 230                 235                 240 


Ser Arg Lys Asp Lys Glu Arg Leu Lys Gln Lys His Lys Lys Arg Pro 
                245                 250                 255     


Glu Ser Pro Pro Ser Ile Leu Thr Pro Pro Val Val Pro Thr Ala Asp 
            260                 265                 270         


Lys Val Ser Ser Ser Ala Ser Ser Ser Ser His His Glu Ala Ser Thr 
        275                 280                 285             


Gln Glu Thr Ser Glu Ser Ser Arg Glu Ser Lys Gly Lys Lys Ser Ser 
    290                 295                 300                 


Ser His Ser Leu Ser His Lys Gly Lys Lys Leu Ser Ser Gly Lys Gly 
305                 310                 315                 320 


Val Ser Ser Phe Thr Ser Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser 
                325                 330                 335     


Ser Ser Gly Gly Pro Phe Gln Pro Ala Val Ser Ser Leu Gln Ser Ser 
            340                 345                 350         


Pro Asp Phe Ser Ala Phe Pro Lys Leu Glu Gln Pro Glu Glu Asp Lys 
        355                 360                 365             


Tyr Ser Lys Pro Thr Ala Pro Ala Pro Ser Ala Pro Pro Ser Pro Ser 
    370                 375                 380                 


Ala Pro Glu Pro Pro Lys Ala Asp Leu Phe Glu Gln Lys Val Val Phe 
385                 390                 395                 400 


Ser Gly Phe Gly Pro Ile Met Arg Phe Ser Thr Thr Thr Ser Ser Ser 
                405                 410                 415     


Gly Arg Ala Arg Ala Pro Ser Pro Gly Asp Tyr Lys Ser Pro His Val 
            420                 425                 430         


Thr Gly Ser Gly Ala Ser Ala Gly Thr His Lys Arg Met Pro Ala Leu 
        435                 440                 445             


Ser Ala Thr Pro Val Pro Ala Asp Glu Thr Pro Glu Thr Gly Leu Lys 
    450                 455                 460                 


Glu Lys Lys His Lys Ala Ser Lys Arg Ser Arg His Gly Pro Gly Arg 
465                 470                 475                 480 


Pro Lys Gly Ser Arg Asn Lys Glu Gly Thr Gly Gly Pro Ala Ala Pro 
                485                 490                 495     


Ser Leu Pro Ser Ala Gln Leu Ala Gly Phe Thr Ala Thr Ala Ala Ser 
            500                 505                 510         


Pro Phe Ser Gly Gly Ser Leu Val Ser Ser Gly Leu Gly Gly Leu Ser 
        515                 520                 525             


Ser Arg Thr Phe Gly Pro Ser Gly Ser Leu Pro Ser Leu Ser Leu Glu 
    530                 535                 540                 


Ser Pro Leu Leu Gly Ala Gly Ile Tyr Thr Ser Asn Lys Asp Pro Ile 
545                 550                 555                 560 


Ser His Ser Gly Gly Met Leu Arg Ala Val Cys Ser Thr Pro Leu Ser 
                565                 570                 575     


Ser Ser Leu Leu Gly Pro Pro Gly Thr Ser Ala Leu Pro Arg Leu Ser 
            580                 585                 590         


Arg Ser Pro Phe Thr Ser Thr Leu Pro Ser Ser Ser Ala Ser Ile Ser 
        595                 600                 605             


Thr Thr Gln Val Phe Ser Leu Ala Gly Ser Thr Phe Ser Leu Pro Ser 
    610                 615                 620                 


Thr His Ile Phe Gly Thr Pro Met Gly Ala Val Asn Pro Leu Leu Ser 
625                 630                 635                 640 


Gln Ala Glu Ser Ser His Thr Glu Pro Asp Leu Glu Asp Cys Ser Phe 
                645                 650                 655     


Arg Cys Arg Gly Thr Ser Pro Gln Glu Ser Leu Ser Ser Met Ser Pro 
            660                 665                 670         


Ile Ser Ser Leu Pro Ala Leu Phe Asp Gln Thr Ala Ser Ala Pro Cys 
        675                 680                 685             


Gly Gly Gly Gln Leu Asp Pro Ala Ala Pro Gly Thr Thr Asn Met Glu 
    690                 695                 700                 


Gln Leu Leu Glu Lys Gln Gly Asp Gly Glu Ala Gly Val Asn Ile Val 
705                 710                 715                 720 


Glu Met Leu Lys Ala Leu His Ala Leu Gln Lys Glu Asn Gln Arg Leu 
                725                 730                 735     


Gln Glu Gln Ile Leu Ser Leu Thr Ala Lys Lys Glu Arg Leu Gln Ile 
            740                 745                 750         


Leu Asn Val Gln Leu Ser Val Pro Phe Pro Ala Leu Pro Ala Ala Leu 
        755                 760                 765             


Pro Ala Ala Asn Gly Pro Val Pro Gly Pro Tyr Gly Leu Pro Pro Gln 
    770                 775                 780                 


Ala Gly Ser Ser Asp Ser Leu Ser Thr Ser Lys Ser Pro Pro Gly Lys 
785                 790                 795                 800 


Ser Ser Leu Gly Leu Asp Asn Ser Leu Ser Thr Ser Ser Glu Asp Pro 
                805                 810                 815     


His Ser Gly Cys Pro Ser Arg Ser Ser Ser Ser Leu Ser Phe His Ser 
            820                 825                 830         


Thr Pro Pro Pro Leu Pro Leu Leu Gln Gln Ser Pro Ala Thr Leu Pro 
        835                 840                 845             


Leu Ala Leu Pro Gly Ala Pro Ala Pro Leu Pro Pro Gln Pro Gln Asn 
    850                 855                 860                 


Gly Leu Gly Arg Ala Pro Gly Ala Ala Gly Leu Gly Ala Met Pro Met 
865                 870                 875                 880 


Ala Glu Gly Leu Leu Gly Gly Leu Ala Gly Ser Gly Gly Leu Pro Leu 
                885                 890                 895     


Asn Gly Leu Leu Gly Gly Leu Asn Gly Ala Ala Ala Pro Asn Pro Ala 
            900                 905                 910         


Ser Leu Ser Gln Ala Gly Gly Ala Pro Thr Leu Gln Leu Pro Gly Cys 
        915                 920                 925             


Leu Asn Ser Leu Thr Glu Gln Gln Arg His Leu Leu Gln Gln Gln Glu 
    930                 935                 940                 


Gln Gln Leu Gln Gln Leu Gln Gln Leu Leu Ala Ser Pro Gln Leu Thr 
945                 950                 955                 960 


Pro Glu His Gln Thr Val Val Tyr Gln Met Ile Gln Gln Ile Gln Gln 
                965                 970                 975     


Lys Arg Glu Leu Gln Arg Leu Gln Met Ala Gly Gly Ser Gln Leu Pro 
            980                 985                 990         


Met Ala Ser Leu Leu Ala Gly Ser  Ser Thr Pro Leu Leu  Ser Ala Gly 
        995                 1000                 1005             


Thr Pro  Gly Leu Leu Pro Thr  Ala Ser Ala Pro Pro  Leu Leu Pro 
    1010                 1015                 1020             


Ala Gly  Ala Leu Val Ala Pro  Ser Leu Gly Asn Asn  Thr Ser Leu 
    1025                 1030                 1035             


Met Ala  Ala Ala Ala Ala Ala  Ala Ala Val Ala Ala  Ala Gly Gly 
    1040                 1045                 1050             


Pro Pro  Val Leu Thr Ala Gln  Thr Asn Pro Phe Leu  Ser Leu Ser 
    1055                 1060                 1065             


Gly Ala  Glu Gly Ser Gly Gly  Gly Pro Lys Gly Gly  Thr Ala Asp 
    1070                 1075                 1080             


Lys Gly  Ala Ser Ala Asn Gln  Glu Lys Gly 
    1085                 1090             


<210>  70
<211>  594
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Val Leu Leu His Val Leu Phe Glu His Ala Val Gly Tyr Ala Leu 
1               5                   10                  15      


Leu Ala Leu Lys Glu Val Glu Glu Ile Ser Leu Leu Gln Pro Gln Val 
            20                  25                  30          


Glu Glu Ser Val Leu Asn Leu Gly Lys Phe His Ser Ile Val Arg Leu 
        35                  40                  45              


Val Ala Phe Cys Pro Phe Ala Ser Ser Gln Val Ala Leu Glu Asn Ala 
    50                  55                  60                  


Asn Ala Val Ser Glu Gly Val Val His Glu Asp Leu Arg Leu Leu Leu 
65                  70                  75                  80  


Glu Thr His Leu Pro Ser Lys Lys Lys Lys Val Leu Leu Gly Val Gly 
                85                  90                  95      


Asp Pro Lys Ile Gly Ala Ala Ile Gln Glu Glu Leu Gly Tyr Asn Cys 
            100                 105                 110         


Gln Thr Gly Gly Val Ile Ala Glu Ile Leu Arg Gly Val Arg Leu His 
        115                 120                 125             


Phe His Asn Leu Val Lys Gly Leu Thr Asp Leu Ser Ala Cys Lys Ala 
    130                 135                 140                 


Gln Leu Gly Leu Gly His Ser Tyr Ser Arg Ala Lys Val Lys Phe Asn 
145                 150                 155                 160 


Val Asn Arg Val Asp Asn Met Ile Ile Gln Ser Ile Ser Leu Leu Asp 
                165                 170                 175     


Gln Leu Asp Lys Asp Ile Asn Thr Phe Ser Met Arg Val Arg Glu Trp 
            180                 185                 190         


Tyr Gly Tyr His Phe Pro Glu Leu Val Lys Ile Ile Asn Asp Asn Ala 
        195                 200                 205             


Thr Tyr Cys Arg Leu Ala Gln Phe Ile Gly Asn Arg Arg Glu Leu Asn 
    210                 215                 220                 


Glu Asp Lys Leu Glu Lys Leu Glu Glu Leu Thr Met Asp Gly Ala Lys 
225                 230                 235                 240 


Ala Lys Ala Ile Leu Asp Ala Ser Arg Ser Ser Met Gly Met Asp Ile 
                245                 250                 255     


Ser Ala Ile Asp Leu Ile Asn Ile Glu Ser Phe Ser Ser Arg Val Val 
            260                 265                 270         


Ser Leu Ser Glu Tyr Arg Gln Ser Leu His Thr Tyr Leu Arg Ser Lys 
        275                 280                 285             


Met Ser Gln Val Ala Pro Ser Leu Ser Ala Leu Ile Gly Glu Ala Val 
    290                 295                 300                 


Gly Ala Arg Leu Ile Ala His Ala Gly Ser Leu Thr Asn Leu Ala Lys 
305                 310                 315                 320 


Tyr Pro Ala Ser Thr Val Gln Ile Leu Gly Ala Glu Lys Ala Leu Phe 
                325                 330                 335     


Arg Ala Leu Lys Thr Arg Gly Asn Thr Pro Lys Tyr Gly Leu Ile Phe 
            340                 345                 350         


His Ser Thr Phe Ile Gly Arg Ala Ala Ala Lys Asn Lys Gly Arg Ile 
        355                 360                 365             


Ser Arg Tyr Leu Ala Asn Lys Cys Ser Ile Ala Ser Arg Ile Asp Cys 
    370                 375                 380                 


Phe Ser Glu Val Pro Thr Ser Val Phe Gly Glu Lys Leu Arg Glu Gln 
385                 390                 395                 400 


Val Glu Glu Arg Leu Ser Phe Tyr Glu Thr Gly Glu Ile Pro Arg Lys 
                405                 410                 415     


Asn Leu Asp Val Met Lys Glu Ala Met Val Gln Ala Glu Glu Ala Ala 
            420                 425                 430         


Ala Glu Ile Thr Arg Lys Leu Glu Lys Gln Glu Lys Lys Arg Leu Lys 
        435                 440                 445             


Lys Glu Lys Lys Arg Leu Ala Ala Leu Ala Leu Ala Ser Ser Glu Asn 
    450                 455                 460                 


Ser Ser Ser Thr Pro Glu Glu Cys Glu Glu Met Ser Glu Lys Pro Lys 
465                 470                 475                 480 


Lys Lys Lys Lys Gln Lys Pro Gln Glu Val Pro Gln Glu Asn Gly Met 
                485                 490                 495     


Glu Asp Pro Ser Ile Ser Phe Ser Lys Pro Lys Lys Lys Lys Ser Phe 
            500                 505                 510         


Ser Lys Glu Glu Leu Met Ser Ser Asp Leu Glu Glu Thr Ala Gly Ser 
        515                 520                 525             


Thr Ser Ile Pro Lys Arg Lys Lys Ser Thr Pro Lys Glu Glu Thr Val 
    530                 535                 540                 


Asn Asp Pro Glu Glu Ala Gly His Arg Ser Gly Ser Lys Lys Lys Arg 
545                 550                 555                 560 


Lys Phe Ser Lys Glu Glu Pro Val Ser Ser Gly Pro Glu Glu Ala Val 
                565                 570                 575     


Gly Lys Ser Ser Ser Lys Lys Lys Lys Lys Phe His Lys Ala Ser Gln 
            580                 585                 590         


Glu Asp 
        


<210>  71
<211>  2115
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Thr Leu His Ala Thr Arg Gly Ala Ala Leu Leu Ser Trp Val Asn 
1               5                   10                  15      


Ser Leu His Val Ala Asp Pro Val Glu Ala Val Leu Gln Leu Gln Asp 
            20                  25                  30          


Cys Ser Ile Phe Ile Lys Ile Ile Asp Arg Ile His Gly Thr Glu Glu 
        35                  40                  45              


Gly Gln Gln Ile Leu Lys Gln Pro Val Ser Glu Arg Leu Asp Phe Val 
    50                  55                  60                  


Cys Ser Phe Leu Gln Lys Asn Arg Lys His Pro Ser Ser Pro Glu Cys 
65                  70                  75                  80  


Leu Val Ser Ala Gln Lys Val Leu Glu Gly Ser Glu Leu Glu Leu Ala 
                85                  90                  95      


Lys Met Thr Met Leu Leu Leu Tyr His Ser Thr Met Ser Ser Lys Ser 
            100                 105                 110         


Pro Arg Asp Trp Glu Gln Phe Glu Tyr Lys Ile Gln Ala Glu Leu Ala 
        115                 120                 125             


Val Ile Leu Lys Phe Val Leu Asp His Glu Asp Gly Leu Asn Leu Asn 
    130                 135                 140                 


Glu Asp Leu Glu Asn Phe Leu Gln Lys Ala Pro Val Pro Ser Thr Cys 
145                 150                 155                 160 


Ser Ser Thr Phe Pro Glu Glu Leu Ser Pro Pro Ser His Gln Ala Lys 
                165                 170                 175     


Arg Glu Ile Arg Phe Leu Glu Leu Gln Lys Val Ala Ser Ser Ser Ser 
            180                 185                 190         


Gly Asn Asn Phe Leu Ser Gly Ser Pro Ala Ser Pro Met Gly Asp Ile 
        195                 200                 205             


Leu Gln Thr Pro Gln Phe Gln Met Arg Arg Leu Lys Lys Gln Leu Ala 
    210                 215                 220                 


Asp Glu Arg Ser Asn Arg Asp Glu Leu Glu Leu Glu Leu Ala Glu Asn 
225                 230                 235                 240 


Arg Lys Leu Leu Thr Glu Lys Asp Ala Gln Ile Ala Met Met Gln Gln 
                245                 250                 255     


Arg Ile Asp Arg Leu Ala Leu Leu Asn Glu Lys Gln Ala Ala Ser Pro 
            260                 265                 270         


Leu Glu Pro Lys Glu Leu Glu Glu Leu Arg Asp Lys Asn Glu Ser Leu 
        275                 280                 285             


Thr Met Arg Leu His Glu Thr Leu Lys Gln Cys Gln Asp Leu Lys Thr 
    290                 295                 300                 


Glu Lys Ser Gln Met Asp Arg Lys Ile Asn Gln Leu Ser Glu Glu Asn 
305                 310                 315                 320 


Gly Asp Leu Ser Phe Lys Leu Arg Glu Phe Ala Ser His Leu Gln Gln 
                325                 330                 335     


Leu Gln Asp Ala Leu Asn Glu Leu Thr Glu Glu His Ser Lys Ala Thr 
            340                 345                 350         


Gln Glu Trp Leu Glu Lys Gln Ala Gln Leu Glu Lys Glu Leu Ser Ala 
        355                 360                 365             


Ala Leu Gln Asp Lys Lys Cys Leu Glu Glu Lys Asn Glu Ile Leu Gln 
    370                 375                 380                 


Gly Lys Leu Ser Gln Leu Glu Glu His Leu Ser Gln Leu Gln Asp Asn 
385                 390                 395                 400 


Pro Pro Gln Glu Lys Gly Glu Val Leu Gly Asp Val Leu Gln Leu Glu 
                405                 410                 415     


Thr Leu Lys Gln Glu Ala Ala Thr Leu Ala Ala Asn Asn Thr Gln Leu 
            420                 425                 430         


Gln Ala Arg Val Glu Met Leu Glu Thr Glu Arg Gly Gln Gln Glu Ala 
        435                 440                 445             


Lys Leu Leu Ala Glu Arg Gly His Phe Glu Glu Glu Lys Gln Gln Leu 
    450                 455                 460                 


Ser Ser Leu Ile Thr Asp Leu Gln Ser Ser Ile Ser Asn Leu Ser Gln 
465                 470                 475                 480 


Ala Lys Glu Glu Leu Glu Gln Ala Ser Gln Ala His Gly Ala Arg Leu 
                485                 490                 495     


Thr Ala Gln Val Ala Ser Leu Thr Ser Glu Leu Thr Thr Leu Asn Ala 
            500                 505                 510         


Thr Ile Gln Gln Gln Asp Gln Glu Leu Ala Gly Leu Lys Gln Gln Ala 
        515                 520                 525             


Lys Glu Lys Gln Ala Gln Leu Ala Gln Thr Leu Gln Gln Gln Glu Gln 
    530                 535                 540                 


Ala Ser Gln Gly Leu Arg His Gln Val Glu Gln Leu Ser Ser Ser Leu 
545                 550                 555                 560 


Lys Gln Lys Glu Gln Gln Leu Lys Glu Val Ala Glu Lys Gln Glu Ala 
                565                 570                 575     


Thr Arg Gln Asp His Ala Gln Gln Leu Ala Thr Ala Ala Glu Glu Arg 
            580                 585                 590         


Glu Ala Ser Leu Arg Glu Arg Asp Ala Ala Leu Lys Gln Leu Glu Ala 
        595                 600                 605             


Leu Glu Lys Glu Lys Ala Ala Lys Leu Glu Ile Leu Gln Gln Gln Leu 
    610                 615                 620                 


Gln Val Ala Asn Glu Ala Arg Asp Ser Ala Gln Thr Ser Val Thr Gln 
625                 630                 635                 640 


Ala Gln Arg Glu Lys Ala Glu Leu Ser Arg Lys Val Glu Glu Leu Gln 
                645                 650                 655     


Ala Cys Val Glu Thr Ala Arg Gln Glu Gln His Glu Ala Gln Ala Gln 
            660                 665                 670         


Val Ala Glu Leu Glu Leu Gln Leu Arg Ser Glu Gln Gln Lys Ala Thr 
        675                 680                 685             


Glu Lys Glu Arg Val Ala Gln Glu Lys Asp Gln Leu Gln Glu Gln Leu 
    690                 695                 700                 


Gln Ala Leu Lys Glu Ser Leu Lys Val Thr Lys Gly Ser Leu Glu Glu 
705                 710                 715                 720 


Glu Lys Arg Arg Ala Ala Asp Ala Leu Glu Glu Gln Gln Arg Cys Ile 
                725                 730                 735     


Ser Glu Leu Lys Ala Glu Thr Arg Ser Leu Val Glu Gln His Lys Arg 
            740                 745                 750         


Glu Arg Lys Glu Leu Glu Glu Glu Arg Ala Gly Arg Lys Gly Leu Glu 
        755                 760                 765             


Ala Arg Leu Gln Gln Leu Gly Glu Ala His Gln Ala Glu Thr Glu Val 
    770                 775                 780                 


Leu Arg Arg Glu Leu Ala Glu Ala Met Ala Ala Gln His Thr Ala Glu 
785                 790                 795                 800 


Ser Glu Cys Glu Gln Leu Val Lys Glu Val Ala Ala Trp Arg Glu Arg 
                805                 810                 815     


Tyr Glu Asp Ser Gln Gln Glu Glu Ala Gln Tyr Gly Ala Met Phe Gln 
            820                 825                 830         


Glu Gln Leu Met Thr Leu Lys Glu Glu Cys Glu Lys Ala Arg Gln Glu 
        835                 840                 845             


Leu Gln Glu Ala Lys Glu Lys Val Ala Gly Ile Glu Ser His Ser Glu 
    850                 855                 860                 


Leu Gln Ile Ser Arg Gln Gln Asn Glu Leu Ala Glu Leu His Ala Asn 
865                 870                 875                 880 


Leu Ala Arg Ala Leu Gln Gln Val Gln Glu Lys Glu Val Arg Ala Gln 
                885                 890                 895     


Lys Leu Ala Asp Asp Leu Ser Thr Leu Gln Glu Lys Met Ala Ala Thr 
            900                 905                 910         


Ser Lys Glu Val Ala Arg Leu Glu Thr Leu Val Arg Lys Ala Gly Glu 
        915                 920                 925             


Gln Gln Glu Thr Ala Ser Arg Glu Leu Val Lys Glu Pro Ala Arg Ala 
    930                 935                 940                 


Gly Asp Arg Gln Pro Glu Trp Leu Glu Glu Gln Gln Gly Arg Gln Phe 
945                 950                 955                 960 


Cys Ser Thr Gln Ala Ala Leu Gln Ala Met Glu Arg Glu Ala Glu Gln 
                965                 970                 975     


Met Gly Asn Glu Leu Glu Arg Leu Arg Ala Ala Leu Met Glu Ser Gln 
            980                 985                 990         


Gly Gln Gln Gln Glu Glu Arg Gly  Gln Gln Glu Arg Glu  Val Ala Arg 
        995                 1000                 1005             


Leu Thr  Gln Glu Arg Gly Arg  Ala Gln Ala Asp Leu  Ala Leu Glu 
    1010                 1015                 1020             


Lys Ala  Ala Arg Ala Glu Leu  Glu Met Arg Leu Gln  Asn Ala Leu 
    1025                 1030                 1035             


Asn Glu  Gln Arg Val Glu Phe  Ala Thr Leu Gln Glu  Ala Leu Ala 
    1040                 1045                 1050             


His Ala  Leu Thr Glu Lys Glu  Gly Lys Asp Gln Glu  Leu Ala Lys 
    1055                 1060                 1065             


Leu Arg  Gly Leu Glu Ala Ala  Gln Ile Lys Glu Leu  Glu Glu Leu 
    1070                 1075                 1080             


Arg Gln  Thr Val Lys Gln Leu  Lys Glu Gln Leu Ala  Lys Lys Glu 
    1085                 1090                 1095             


Lys Glu  His Ala Ser Gly Ser  Gly Ala Gln Ser Glu  Ala Ala Gly 
    1100                 1105                 1110             


Arg Thr  Glu Pro Thr Gly Pro  Lys Leu Glu Ala Leu  Arg Ala Glu 
    1115                 1120                 1125             


Val Ser  Lys Leu Glu Gln Gln  Cys Gln Lys Gln Gln  Glu Gln Ala 
    1130                 1135                 1140             


Asp Ser  Leu Glu Arg Ser Leu  Glu Ala Glu Arg Ala  Ser Arg Ala 
    1145                 1150                 1155             


Glu Arg  Asp Ser Ala Leu Glu  Thr Leu Gln Gly Gln  Leu Glu Glu 
    1160                 1165                 1170             


Lys Ala  Gln Glu Leu Gly His  Ser Gln Ser Ala Leu  Ala Ser Ala 
    1175                 1180                 1185             


Gln Arg  Glu Leu Ala Ala Phe  Arg Thr Lys Val Gln  Asp His Ser 
    1190                 1195                 1200             


Lys Ala  Glu Asp Glu Trp Lys  Ala Gln Val Ala Arg  Gly Arg Gln 
    1205                 1210                 1215             


Glu Ala  Glu Arg Lys Asn Ser  Leu Ile Ser Ser Leu  Glu Glu Glu 
    1220                 1225                 1230             


Val Ser  Ile Leu Asn Arg Gln  Val Leu Glu Lys Glu  Gly Glu Ser 
    1235                 1240                 1245             


Lys Glu  Leu Lys Arg Leu Val  Met Ala Glu Ser Glu  Lys Ser Gln 
    1250                 1255                 1260             


Lys Leu  Glu Glu Arg Leu Arg  Leu Leu Gln Ala Glu  Thr Ala Ser 
    1265                 1270                 1275             


Asn Ser  Ala Arg Ala Ala Glu  Arg Ser Ser Ala Leu  Arg Glu Glu 
    1280                 1285                 1290             


Val Gln  Ser Leu Arg Glu Glu  Ala Glu Lys Gln Arg  Val Ala Ser 
    1295                 1300                 1305             


Glu Asn  Leu Arg Gln Glu Leu  Thr Ser Gln Ala Glu  Arg Ala Glu 
    1310                 1315                 1320             


Glu Leu  Gly Gln Glu Leu Lys  Ala Trp Gln Glu Lys  Phe Phe Gln 
    1325                 1330                 1335             


Lys Glu  Gln Ala Leu Ser Thr  Leu Gln Leu Glu His  Thr Ser Thr 
    1340                 1345                 1350             


Gln Ala  Leu Val Ser Glu Leu  Leu Pro Ala Lys His  Leu Cys Gln 
    1355                 1360                 1365             


Gln Leu  Gln Ala Glu Gln Ala  Ala Ala Glu Lys Arg  His Arg Glu 
    1370                 1375                 1380             


Glu Leu  Glu Gln Ser Lys Gln  Ala Ala Gly Gly Leu  Arg Ala Glu 
    1385                 1390                 1395             


Leu Leu  Arg Ala Gln Arg Glu  Leu Gly Glu Leu Ile  Pro Leu Arg 
    1400                 1405                 1410             


Gln Lys  Val Ala Glu Gln Glu  Arg Thr Ala Gln Gln  Leu Arg Ala 
    1415                 1420                 1425             


Glu Lys  Ala Ser Tyr Ala Glu  Gln Leu Ser Met Leu  Lys Lys Ala 
    1430                 1435                 1440             


His Gly  Leu Leu Ala Glu Glu  Asn Arg Gly Leu Gly  Glu Arg Ala 
    1445                 1450                 1455             


Asn Leu  Gly Arg Gln Phe Leu  Glu Val Glu Leu Asp  Gln Ala Arg 
    1460                 1465                 1470             


Glu Lys  Tyr Val Gln Glu Leu  Ala Ala Val Arg Ala  Asp Ala Glu 
    1475                 1480                 1485             


Thr Arg  Leu Ala Glu Val Gln  Arg Glu Ala Gln Ser  Thr Ala Arg 
    1490                 1495                 1500             


Glu Leu  Glu Val Met Thr Ala  Lys Tyr Glu Gly Ala  Lys Val Lys 
    1505                 1510                 1515             


Val Leu  Glu Glu Arg Gln Arg  Phe Gln Glu Glu Arg  Gln Lys Leu 
    1520                 1525                 1530             


Thr Ala  Gln Val Glu Gln Leu  Glu Val Phe Gln Arg  Glu Gln Thr 
    1535                 1540                 1545             


Lys Gln  Val Glu Glu Leu Ser  Lys Lys Leu Ala Asp  Ser Asp Gln 
    1550                 1555                 1560             


Ala Ser  Lys Val Gln Gln Gln  Lys Leu Lys Ala Val  Gln Ala Gln 
    1565                 1570                 1575             


Gly Gly  Glu Ser Gln Gln Glu  Ala Gln Arg Leu Gln  Ala Gln Leu 
    1580                 1585                 1590             


Asn Glu  Leu Gln Ala Gln Leu  Ser Gln Lys Glu Gln  Ala Ala Glu 
    1595                 1600                 1605             


His Tyr  Lys Leu Gln Met Glu  Lys Ala Lys Thr His  Tyr Asp Ala 
    1610                 1615                 1620             


Lys Lys  Gln Gln Asn Gln Glu  Leu Gln Glu Gln Leu  Arg Ser Leu 
    1625                 1630                 1635             


Glu Gln  Leu Gln Lys Glu Asn  Lys Glu Leu Arg Ala  Glu Ala Glu 
    1640                 1645                 1650             


Arg Leu  Gly His Glu Leu Gln  Gln Ala Gly Leu Lys  Thr Lys Glu 
    1655                 1660                 1665             


Ala Glu  Gln Thr Cys Arg His  Leu Thr Ala Gln Val  Arg Ser Leu 
    1670                 1675                 1680             


Glu Ala  Gln Val Ala His Ala  Asp Gln Gln Leu Arg  Asp Leu Gly 
    1685                 1690                 1695             


Lys Phe  Gln Val Ala Thr Asp  Ala Leu Lys Ser Arg  Glu Pro Gln 
    1700                 1705                 1710             


Ala Lys  Pro Gln Leu Asp Leu  Ser Ile Asp Ser Leu  Asp Leu Ser 
    1715                 1720                 1725             


Cys Glu  Glu Gly Thr Pro Leu  Ser Ile Thr Ser Lys  Leu Pro Arg 
    1730                 1735                 1740             


Thr Gln  Pro Asp Gly Thr Ser  Val Pro Gly Glu Pro  Ala Ser Pro 
    1745                 1750                 1755             


Ile Ser  Gln Arg Leu Pro Pro  Lys Val Glu Ser Leu  Glu Ser Leu 
    1760                 1765                 1770             


Tyr Phe  Thr Pro Ile Pro Ala  Arg Ser Gln Ala Pro  Leu Glu Ser 
    1775                 1780                 1785             


Ser Leu  Asp Ser Leu Gly Asp  Val Phe Leu Asp Ser  Gly Arg Lys 
    1790                 1795                 1800             


Thr Arg  Ser Ala Arg Arg Arg  Thr Thr Gln Ile Ile  Asn Ile Thr 
    1805                 1810                 1815             


Met Thr  Lys Lys Leu Asp Val  Glu Glu Pro Asp Ser  Ala Asn Ser 
    1820                 1825                 1830             


Ser Phe  Tyr Ser Thr Arg Ser  Ala Pro Ala Ser Gln  Ala Ser Leu 
    1835                 1840                 1845             


Arg Ala  Thr Ser Ser Thr Gln  Ser Leu Ala Arg Leu  Gly Ser Pro 
    1850                 1855                 1860             


Asp Tyr  Gly Asn Ser Ala Leu  Leu Ser Leu Pro Gly  Tyr Arg Pro 
    1865                 1870                 1875             


Thr Thr  Arg Ser Ser Ala Arg  Arg Ser Gln Ala Gly  Val Ser Ser 
    1880                 1885                 1890             


Gly Ala  Pro Pro Gly Arg Asn  Ser Phe Tyr Met Gly  Thr Cys Gln 
    1895                 1900                 1905             


Asp Glu  Pro Glu Gln Leu Asp  Asp Trp Asn Arg Ile  Ala Glu Leu 
    1910                 1915                 1920             


Gln Gln  Arg Asn Arg Val Cys  Pro Pro His Leu Lys  Thr Cys Tyr 
    1925                 1930                 1935             


Pro Leu  Glu Ser Arg Pro Ser  Leu Ser Leu Gly Thr  Ile Thr Asp 
    1940                 1945                 1950             


Glu Glu  Met Lys Thr Gly Asp  Pro Gln Glu Thr Leu  Arg Arg Ala 
    1955                 1960                 1965             


Ser Met  Gln Pro Ile Gln Ile  Ala Glu Gly Thr Gly  Ile Thr Thr 
    1970                 1975                 1980             


Arg Gln  Gln Arg Lys Arg Val  Ser Leu Glu Pro His  Gln Gly Pro 
    1985                 1990                 1995             


Gly Thr  Pro Glu Ser Lys Lys  Ala Thr Ser Cys Phe  Pro Arg Pro 
    2000                 2005                 2010             


Met Thr  Pro Arg Asp Arg His  Glu Gly Arg Lys Gln  Ser Thr Thr 
    2015                 2020                 2025             


Glu Ala  Gln Lys Lys Ala Ala  Pro Ala Ser Thr Lys  Gln Ala Asp 
    2030                 2035                 2040             


Arg Arg  Gln Ser Met Ala Phe  Ser Ile Leu Asn Thr  Pro Lys Lys 
    2045                 2050                 2055             


Leu Gly  Asn Ser Leu Leu Arg  Arg Gly Ala Ser Lys  Lys Ala Leu 
    2060                 2065                 2070             


Ser Lys  Ala Ser Pro Asn Thr  Arg Ser Gly Thr Arg  Arg Ser Pro 
    2075                 2080                 2085             


Arg Ile  Ala Thr Thr Thr Ala  Ser Ala Ala Thr Ala  Ala Ala Ile 
    2090                 2095                 2100             


Gly Ala  Thr Pro Arg Ala Lys  Gly Lys Ala Lys His  
    2105                 2110                 2115 


<210>  72
<211>  2696
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Asp Gln Thr Cys Glu Leu Pro Arg Arg Asn Cys Leu Leu Pro Phe 
1               5                   10                  15      


Ser Asn Pro Val Asn Leu Asp Ala Pro Glu Asp Lys Asp Ser Pro Phe 
            20                  25                  30          


Gly Asn Gly Gln Ser Asn Phe Ser Glu Pro Leu Asn Gly Cys Thr Met 
        35                  40                  45              


Gln Leu Ser Thr Val Ser Gly Thr Ser Gln Asn Ala Tyr Gly Gln Asp 
    50                  55                  60                  


Ser Pro Ser Cys Tyr Ile Pro Leu Arg Arg Leu Gln Asp Leu Ala Ser 
65                  70                  75                  80  


Met Ile Asn Val Glu Tyr Leu Asn Gly Ser Ala Asp Gly Ser Glu Ser 
                85                  90                  95      


Phe Gln Asp Pro Glu Lys Ser Asp Ser Arg Ala Gln Thr Pro Ile Val 
            100                 105                 110         


Cys Thr Ser Leu Ser Pro Gly Gly Pro Thr Ala Leu Ala Met Lys Gln 
        115                 120                 125             


Glu Pro Ser Cys Asn Asn Ser Pro Glu Leu Gln Val Lys Val Thr Lys 
    130                 135                 140                 


Thr Ile Lys Asn Gly Phe Leu His Phe Glu Asn Phe Thr Cys Val Asp 
145                 150                 155                 160 


Asp Ala Asp Val Asp Ser Glu Met Asp Pro Glu Gln Pro Val Thr Glu 
                165                 170                 175     


Asp Glu Ser Ile Glu Glu Ile Phe Glu Glu Thr Gln Thr Asn Ala Thr 
            180                 185                 190         


Cys Asn Tyr Glu Thr Lys Ser Glu Asn Gly Val Lys Val Ala Met Gly 
        195                 200                 205             


Ser Glu Gln Asp Ser Thr Pro Glu Ser Arg His Gly Ala Val Lys Ser 
    210                 215                 220                 


Pro Phe Leu Pro Leu Ala Pro Gln Thr Glu Thr Gln Lys Asn Lys Gln 
225                 230                 235                 240 


Arg Asn Glu Val Asp Gly Ser Asn Glu Lys Ala Ala Leu Leu Pro Ala 
                245                 250                 255     


Pro Phe Ser Leu Gly Asp Thr Asn Ile Thr Ile Glu Glu Gln Leu Asn 
            260                 265                 270         


Ser Ile Asn Leu Ser Phe Gln Asp Asp Pro Asp Ser Ser Thr Ser Thr 
        275                 280                 285             


Leu Gly Asn Met Leu Glu Leu Pro Gly Thr Ser Ser Ser Ser Thr Ser 
    290                 295                 300                 


Gln Glu Leu Pro Phe Cys Gln Pro Lys Lys Lys Ser Thr Pro Leu Lys 
305                 310                 315                 320 


Tyr Glu Val Gly Asp Leu Ile Trp Ala Lys Phe Lys Arg Arg Pro Trp 
                325                 330                 335     


Trp Pro Cys Arg Ile Cys Ser Asp Pro Leu Ile Asn Thr His Ser Lys 
            340                 345                 350         


Met Lys Val Ser Asn Arg Arg Pro Tyr Arg Gln Tyr Tyr Val Glu Ala 
        355                 360                 365             


Phe Gly Asp Pro Ser Glu Arg Ala Trp Val Ala Gly Lys Ala Ile Val 
    370                 375                 380                 


Met Phe Glu Gly Arg His Gln Phe Glu Glu Leu Pro Val Leu Arg Arg 
385                 390                 395                 400 


Arg Gly Lys Gln Lys Glu Lys Gly Tyr Arg His Lys Val Pro Gln Lys 
                405                 410                 415     


Ile Leu Ser Lys Trp Glu Ala Ser Val Gly Leu Ala Glu Gln Tyr Asp 
            420                 425                 430         


Val Pro Lys Gly Ser Lys Asn Arg Lys Cys Ile Pro Gly Ser Ile Lys 
        435                 440                 445             


Leu Asp Ser Glu Glu Asp Met Pro Phe Glu Asp Cys Thr Asn Asp Pro 
    450                 455                 460                 


Glu Ser Glu His Asp Leu Leu Leu Asn Gly Cys Leu Lys Ser Leu Ala 
465                 470                 475                 480 


Phe Asp Ser Glu His Ser Ala Asp Glu Lys Glu Lys Pro Cys Ala Lys 
                485                 490                 495     


Ser Arg Ala Arg Lys Ser Ser Asp Asn Pro Lys Arg Thr Ser Val Lys 
            500                 505                 510         


Lys Gly His Ile Gln Phe Glu Ala His Lys Asp Glu Arg Arg Gly Lys 
        515                 520                 525             


Ile Pro Glu Asn Leu Gly Leu Asn Phe Ile Ser Gly Asp Ile Ser Asp 
    530                 535                 540                 


Thr Gln Ala Ser Asn Glu Leu Ser Arg Ile Ala Asn Ser Leu Thr Gly 
545                 550                 555                 560 


Ser Asn Thr Ala Pro Gly Ser Phe Leu Phe Ser Ser Cys Gly Lys Asn 
                565                 570                 575     


Thr Ala Lys Lys Glu Phe Glu Thr Ser Asn Gly Asp Ser Leu Leu Gly 
            580                 585                 590         


Leu Pro Glu Gly Ala Leu Ile Ser Lys Cys Ser Arg Glu Lys Asn Lys 
        595                 600                 605             


Pro Gln Arg Ser Leu Val Cys Gly Ser Lys Val Lys Leu Cys Tyr Ile 
    610                 615                 620                 


Gly Ala Gly Asp Glu Glu Lys Arg Ser Asp Ser Ile Ser Ile Cys Thr 
625                 630                 635                 640 


Thr Ser Asp Asp Gly Ser Ser Asp Leu Asp Pro Ile Glu His Ser Ser 
                645                 650                 655     


Glu Ser Asp Asn Ser Val Leu Glu Ile Pro Asp Ala Phe Asp Arg Thr 
            660                 665                 670         


Glu Asn Met Leu Ser Met Gln Lys Asn Glu Lys Ile Lys Tyr Ser Arg 
        675                 680                 685             


Phe Ala Ala Thr Asn Thr Arg Val Lys Ala Lys Gln Lys Pro Leu Ile 
    690                 695                 700                 


Ser Asn Ser His Thr Asp His Leu Met Gly Cys Thr Lys Ser Ala Glu 
705                 710                 715                 720 


Pro Gly Thr Glu Thr Ser Gln Val Asn Leu Ser Asp Leu Lys Ala Ser 
                725                 730                 735     


Thr Leu Val His Lys Pro Gln Ser Asp Phe Thr Asn Asp Ala Leu Ser 
            740                 745                 750         


Pro Lys Phe Asn Leu Ser Ser Ser Ile Ser Ser Glu Asn Ser Leu Ile 
        755                 760                 765             


Lys Gly Gly Ala Ala Asn Gln Ala Leu Leu His Ser Lys Ser Lys Gln 
    770                 775                 780                 


Pro Lys Phe Arg Ser Ile Lys Cys Lys His Lys Glu Asn Pro Val Met 
785                 790                 795                 800 


Ala Glu Pro Pro Val Ile Asn Glu Glu Cys Ser Leu Lys Cys Cys Ser 
                805                 810                 815     


Ser Asp Thr Lys Gly Ser Pro Leu Ala Ser Ile Ser Lys Ser Gly Lys 
            820                 825                 830         


Val Asp Gly Leu Lys Leu Leu Asn Asn Met His Glu Lys Thr Arg Asp 
        835                 840                 845             


Ser Ser Asp Ile Glu Thr Ala Val Val Lys His Val Leu Ser Glu Leu 
    850                 855                 860                 


Lys Glu Leu Ser Tyr Arg Ser Leu Gly Glu Asp Val Ser Asp Ser Gly 
865                 870                 875                 880 


Thr Ser Lys Pro Ser Lys Pro Leu Leu Phe Ser Ser Ala Ser Ser Gln 
                885                 890                 895     


Asn His Ile Pro Ile Glu Pro Asp Tyr Lys Phe Ser Thr Leu Leu Met 
            900                 905                 910         


Met Leu Lys Asp Met His Asp Ser Lys Thr Lys Glu Gln Arg Leu Met 
        915                 920                 925             


Thr Ala Gln Asn Leu Val Ser Tyr Arg Ser Pro Gly Arg Gly Asp Cys 
    930                 935                 940                 


Ser Thr Asn Ser Pro Val Gly Val Ser Lys Val Leu Val Ser Gly Gly 
945                 950                 955                 960 


Ser Thr His Asn Ser Glu Lys Lys Gly Asp Gly Thr Gln Asn Ser Ala 
                965                 970                 975     


Asn Pro Ser Pro Ser Gly Gly Asp Ser Ala Leu Ser Gly Glu Leu Ser 
            980                 985                 990         


Ala Ser Leu Pro Gly Leu Leu Ser  Asp Lys Arg Asp Leu  Pro Ala Ser 
        995                 1000                 1005             


Gly Lys  Ser Arg Ser Asp Cys  Val Thr Arg Arg Asn  Cys Gly Arg 
    1010                 1015                 1020             


Ser Lys  Pro Ser Ser Lys Leu  Arg Asp Ala Phe Ser  Ala Gln Met 
    1025                 1030                 1035             


Val Lys  Asn Thr Val Asn Arg  Lys Ala Leu Lys Thr  Glu Arg Lys 
    1040                 1045                 1050             


Arg Lys  Leu Asn Gln Leu Pro  Ser Val Thr Leu Asp  Ala Val Leu 
    1055                 1060                 1065             


Gln Gly  Asp Arg Glu Arg Gly  Gly Ser Leu Arg Gly  Gly Ala Glu 
    1070                 1075                 1080             


Asp Pro  Ser Lys Glu Asp Pro  Leu Gln Ile Met Gly  His Leu Thr 
    1085                 1090                 1095             


Ser Glu  Asp Gly Asp His Phe  Ser Asp Val His Phe  Asp Ser Lys 
    1100                 1105                 1110             


Val Lys  Gln Ser Asp Pro Gly  Lys Ile Ser Glu Lys  Gly Leu Ser 
    1115                 1120                 1125             


Phe Glu  Asn Gly Lys Gly Pro  Glu Leu Asp Ser Val  Met Asn Ser 
    1130                 1135                 1140             


Glu Asn  Asp Glu Leu Asn Gly  Val Asn Gln Val Val  Pro Lys Lys 
    1145                 1150                 1155             


Arg Trp  Gln Arg Leu Asn Gln  Arg Arg Thr Lys Pro  Arg Lys Arg 
    1160                 1165                 1170             


Met Asn  Arg Phe Lys Glu Lys  Glu Asn Ser Glu Cys  Ala Phe Arg 
    1175                 1180                 1185             


Val Leu  Leu Pro Ser Asp Pro  Val Gln Glu Gly Arg  Asp Glu Phe 
    1190                 1195                 1200             


Pro Glu  His Arg Thr Pro Ser  Ala Ser Ile Leu Glu  Glu Pro Leu 
    1205                 1210                 1215             


Thr Glu  Gln Asn His Ala Asp  Cys Leu Asp Ser Ala  Gly Pro Arg 
    1220                 1225                 1230             


Leu Asn  Val Cys Asp Lys Ser  Ser Ala Ser Ile Gly  Asp Met Glu 
    1235                 1240                 1245             


Lys Glu  Pro Gly Ile Pro Ser  Leu Thr Pro Gln Ala  Glu Leu Pro 
    1250                 1255                 1260             


Glu Pro  Ala Val Arg Ser Glu  Lys Lys Arg Leu Arg  Lys Pro Ser 
    1265                 1270                 1275             


Lys Trp  Leu Leu Glu Tyr Thr  Glu Glu Tyr Asp Gln  Ile Phe Ala 
    1280                 1285                 1290             


Pro Lys  Lys Lys Gln Lys Lys  Val Gln Glu Gln Val  His Lys Val 
    1295                 1300                 1305             


Ser Ser  Arg Cys Glu Glu Glu  Ser Leu Leu Ala Arg  Gly Arg Ser 
    1310                 1315                 1320             


Ser Ala  Gln Asn Lys Gln Val  Asp Glu Asn Ser Leu  Ile Ser Thr 
    1325                 1330                 1335             


Lys Glu  Glu Pro Pro Val Leu  Glu Arg Glu Ala Pro  Phe Leu Glu 
    1340                 1345                 1350             


Gly Pro  Leu Ala Gln Ser Glu  Leu Gly Gly Gly His  Ala Glu Leu 
    1355                 1360                 1365             


Pro Gln  Leu Thr Leu Ser Val  Pro Val Ala Pro Glu  Val Ser Pro 
    1370                 1375                 1380             


Arg Pro  Ala Leu Glu Ser Glu  Glu Leu Leu Val Lys  Thr Pro Gly 
    1385                 1390                 1395             


Asn Tyr  Glu Ser Lys Arg Gln  Arg Lys Pro Thr Lys  Lys Leu Leu 
    1400                 1405                 1410             


Glu Ser  Asn Asp Leu Asp Pro  Gly Phe Met Pro Lys  Lys Gly Asp 
    1415                 1420                 1425             


Leu Gly  Leu Ser Lys Lys Cys  Tyr Glu Ala Gly His  Leu Glu Asn 
    1430                 1435                 1440             


Gly Ile  Thr Glu Ser Cys Ala  Thr Ser Tyr Ser Lys  Asp Phe Gly 
    1445                 1450                 1455             


Gly Gly  Thr Thr Lys Ile Phe  Asp Lys Pro Arg Lys  Arg Lys Arg 
    1460                 1465                 1470             


Gln Arg  His Ala Ala Ala Lys  Met Gln Cys Lys Lys  Val Lys Asn 
    1475                 1480                 1485             


Asp Asp  Ser Ser Lys Glu Ile  Pro Gly Ser Glu Gly  Glu Leu Met 
    1490                 1495                 1500             


Pro His  Arg Thr Ala Thr Ser  Pro Lys Glu Thr Val  Glu Glu Gly 
    1505                 1510                 1515             


Val Glu  His Asp Pro Gly Met  Pro Ala Ser Lys Lys  Met Gln Gly 
    1520                 1525                 1530             


Glu Arg  Gly Gly Gly Ala Ala  Leu Lys Glu Asn Val  Cys Gln Asn 
    1535                 1540                 1545             


Cys Glu  Lys Leu Gly Glu Leu  Leu Leu Cys Glu Ala  Gln Cys Cys 
    1550                 1555                 1560             


Gly Ala  Phe His Leu Glu Cys  Leu Gly Leu Thr Glu  Met Pro Arg 
    1565                 1570                 1575             


Gly Lys  Phe Ile Cys Asn Glu  Cys Arg Thr Gly Ile  His Thr Cys 
    1580                 1585                 1590             


Phe Val  Cys Lys Gln Ser Gly  Glu Asp Val Lys Arg  Cys Leu Leu 
    1595                 1600                 1605             


Pro Leu  Cys Gly Lys Phe Tyr  His Glu Glu Cys Val  Gln Lys Tyr 
    1610                 1615                 1620             


Pro Pro  Thr Val Met Gln Asn  Lys Gly Phe Arg Cys  Ser Leu His 
    1625                 1630                 1635             


Ile Cys  Ile Thr Cys His Ala  Ala Asn Pro Ala Asn  Val Ser Ala 
    1640                 1645                 1650             


Ser Lys  Gly Arg Leu Met Arg  Cys Val Arg Cys Pro  Val Ala Tyr 
    1655                 1660                 1665             


His Ala  Asn Asp Phe Cys Leu  Ala Ala Gly Ser Lys  Ile Leu Ala 
    1670                 1675                 1680             


Ser Asn  Ser Ile Ile Cys Pro  Asn His Phe Thr Pro  Arg Arg Gly 
    1685                 1690                 1695             


Cys Arg  Asn His Glu His Val  Asn Val Ser Trp Cys  Phe Val Cys 
    1700                 1705                 1710             


Ser Glu  Gly Gly Ser Leu Leu  Cys Cys Asp Ser Cys  Pro Ala Ala 
    1715                 1720                 1725             


Phe His  Arg Glu Cys Leu Asn  Ile Asp Ile Pro Glu  Gly Asn Trp 
    1730                 1735                 1740             


Tyr Cys  Asn Asp Cys Lys Ala  Gly Lys Lys Pro His  Tyr Arg Glu 
    1745                 1750                 1755             


Ile Val  Trp Val Lys Val Gly  Arg Tyr Arg Trp Trp  Pro Ala Glu 
    1760                 1765                 1770             


Ile Cys  His Pro Arg Ala Val  Pro Ser Asn Ile Asp  Lys Met Arg 
    1775                 1780                 1785             


His Asp  Val Gly Glu Phe Pro  Val Leu Phe Phe Gly  Ser Asn Asp 
    1790                 1795                 1800             


Tyr Leu  Trp Thr His Gln Ala  Arg Val Phe Pro Tyr  Met Glu Gly 
    1805                 1810                 1815             


Asp Val  Ser Ser Lys Asp Lys  Met Gly Lys Gly Val  Asp Gly Thr 
    1820                 1825                 1830             


Tyr Lys  Lys Ala Leu Gln Glu  Ala Ala Ala Arg Phe  Glu Glu Leu 
    1835                 1840                 1845             


Lys Ala  Gln Lys Glu Leu Arg  Gln Leu Gln Glu Asp  Arg Lys Asn 
    1850                 1855                 1860             


Asp Lys  Lys Pro Pro Pro Tyr  Lys His Ile Lys Val  Asn Arg Pro 
    1865                 1870                 1875             


Ile Gly  Arg Val Gln Ile Phe  Thr Ala Asp Leu Ser  Glu Ile Pro 
    1880                 1885                 1890             


Arg Cys  Asn Cys Lys Ala Thr  Asp Glu Asn Pro Cys  Gly Ile Asp 
    1895                 1900                 1905             


Ser Glu  Cys Ile Asn Arg Met  Leu Leu Tyr Glu Cys  His Pro Thr 
    1910                 1915                 1920             


Val Cys  Pro Ala Gly Gly Arg  Cys Gln Asn Gln Cys  Phe Ser Lys 
    1925                 1930                 1935             


Arg Gln  Tyr Pro Glu Val Glu  Ile Phe Arg Thr Leu  Gln Arg Gly 
    1940                 1945                 1950             


Trp Gly  Leu Arg Thr Lys Thr  Asp Ile Lys Lys Gly  Glu Phe Val 
    1955                 1960                 1965             


Asn Glu  Tyr Val Gly Glu Leu  Ile Asp Glu Glu Glu  Cys Arg Ala 
    1970                 1975                 1980             


Arg Ile  Arg Tyr Ala Gln Glu  His Asp Ile Thr Asn  Phe Tyr Met 
    1985                 1990                 1995             


Leu Thr  Leu Asp Lys Asp Arg  Ile Ile Asp Ala Gly  Pro Lys Gly 
    2000                 2005                 2010             


Asn Tyr  Ala Arg Phe Met Asn  His Cys Cys Gln Pro  Asn Cys Glu 
    2015                 2020                 2025             


Thr Gln  Lys Trp Ser Val Asn  Gly Asp Thr Arg Val  Gly Leu Phe 
    2030                 2035                 2040             


Ala Leu  Ser Asp Ile Lys Ala  Gly Thr Glu Leu Thr  Phe Asn Tyr 
    2045                 2050                 2055             


Asn Leu  Glu Cys Leu Gly Asn  Gly Lys Thr Val Cys  Lys Cys Gly 
    2060                 2065                 2070             


Ala Pro  Asn Cys Ser Gly Phe  Leu Gly Val Arg Pro  Lys Asn Gln 
    2075                 2080                 2085             


Pro Ile  Ala Thr Glu Glu Lys  Ser Lys Lys Phe Lys  Lys Lys Gln 
    2090                 2095                 2100             


Gln Gly  Lys Arg Arg Thr Gln  Gly Glu Ile Thr Lys  Glu Arg Glu 
    2105                 2110                 2115             


Asp Glu  Cys Phe Ser Cys Gly  Asp Ala Gly Gln Leu  Val Ser Cys 
    2120                 2125                 2130             


Lys Lys  Pro Gly Cys Pro Lys  Val Tyr His Ala Asp  Cys Leu Asn 
    2135                 2140                 2145             


Leu Thr  Lys Arg Pro Ala Gly  Lys Trp Glu Cys Pro  Trp His Gln 
    2150                 2155                 2160             


Cys Asp  Ile Cys Gly Lys Glu  Ala Ala Ser Phe Cys  Glu Met Cys 
    2165                 2170                 2175             


Pro Ser  Ser Phe Cys Lys Gln  His Arg Glu Gly Met  Leu Phe Ile 
    2180                 2185                 2190             


Ser Lys  Leu Asp Gly Arg Leu  Ser Cys Thr Glu His  Asp Pro Cys 
    2195                 2200                 2205             


Gly Pro  Asn Pro Leu Glu Pro  Gly Glu Ile Arg Glu  Tyr Val Pro 
    2210                 2215                 2220             


Pro Pro  Val Pro Leu Pro Pro  Gly Pro Ser Thr His  Leu Ala Glu 
    2225                 2230                 2235             


Gln Ser  Thr Gly Met Ala Ala  Gln Ala Pro Lys Met  Ser Asp Lys 
    2240                 2245                 2250             


Pro Pro  Ala Asp Thr Asn Gln  Met Leu Ser Leu Ser  Lys Lys Ala 
    2255                 2260                 2265             


Leu Ala  Gly Thr Cys Gln Arg  Pro Leu Leu Pro Glu  Arg Pro Leu 
    2270                 2275                 2280             


Glu Arg  Thr Asp Ser Arg Pro  Gln Pro Leu Asp Lys  Val Arg Asp 
    2285                 2290                 2295             


Leu Ala  Gly Ser Gly Thr Lys  Ser Gln Ser Leu Val  Ser Ser Gln 
    2300                 2305                 2310             


Arg Pro  Leu Asp Arg Pro Pro  Ala Val Ala Gly Pro  Arg Pro Gln 
    2315                 2320                 2325             


Leu Ser  Asp Lys Pro Ser Pro  Val Thr Ser Pro Ser  Ser Ser Pro 
    2330                 2335                 2340             


Ser Val  Arg Ser Gln Pro Leu  Glu Arg Pro Leu Gly  Thr Ala Asp 
    2345                 2350                 2355             


Pro Arg  Leu Asp Lys Ser Ile  Gly Ala Ala Ser Pro  Arg Pro Gln 
    2360                 2365                 2370             


Ser Leu  Glu Lys Thr Ser Val  Pro Thr Gly Leu Arg  Leu Pro Pro 
    2375                 2380                 2385             


Pro Asp  Arg Leu Leu Ile Thr  Ser Ser Pro Lys Pro  Gln Thr Ser 
    2390                 2395                 2400             


Asp Arg  Pro Thr Asp Lys Pro  His Ala Ser Leu Ser  Gln Arg Leu 
    2405                 2410                 2415             


Pro Pro  Pro Glu Lys Val Leu  Ser Ala Val Val Gln  Thr Leu Val 
    2420                 2425                 2430             


Ala Lys  Glu Lys Ala Leu Arg  Pro Val Asp Gln Asn  Thr Gln Ser 
    2435                 2440                 2445             


Lys Asn  Arg Ala Ala Leu Val  Met Asp Leu Ile Asp  Leu Thr Pro 
    2450                 2455                 2460             


Arg Gln  Lys Glu Arg Ala Ala  Ser Pro His Gln Val  Thr Pro Gln 
    2465                 2470                 2475             


Ala Asp  Glu Lys Met Pro Val  Leu Glu Ser Ser Ser  Trp Pro Ala 
    2480                 2485                 2490             


Ser Lys  Gly Leu Gly His Met  Pro Arg Ala Val Glu  Lys Gly Cys 
    2495                 2500                 2505             


Val Ser  Asp Pro Leu Gln Thr  Ser Gly Lys Ala Ala  Ala Pro Ser 
    2510                 2515                 2520             


Glu Asp  Pro Trp Gln Ala Val  Lys Ser Leu Thr Gln  Ala Arg Leu 
    2525                 2530                 2535             


Leu Ser  Gln Pro Pro Ala Lys  Ala Phe Leu Tyr Glu  Pro Thr Thr 
    2540                 2545                 2550             


Gln Ala  Ser Gly Arg Ala Ser  Ala Gly Ala Glu Gln  Thr Pro Gly 
    2555                 2560                 2565             


Pro Leu  Ser Gln Ser Pro Gly  Leu Val Lys Gln Ala  Lys Gln Met 
    2570                 2575                 2580             


Val Gly  Gly Gln Gln Leu Pro  Ala Leu Ala Ala Lys  Ser Gly Gln 
    2585                 2590                 2595             


Ser Phe  Arg Ser Leu Gly Lys  Ala Pro Ala Ser Leu  Pro Thr Glu 
    2600                 2605                 2610             


Glu Lys  Lys Leu Val Thr Thr  Glu Gln Ser Pro Trp  Ala Leu Gly 
    2615                 2620                 2625             


Lys Ala  Ser Ser Arg Ala Gly  Leu Trp Pro Ile Val  Ala Gly Gln 
    2630                 2635                 2640             


Thr Leu  Ala Gln Ser Cys Trp  Ser Ala Gly Ser Thr  Gln Thr Leu 
    2645                 2650                 2655             


Ala Gln  Thr Cys Trp Ser Leu  Gly Arg Gly Gln Asp  Pro Lys Pro 
    2660                 2665                 2670             


Glu Gln  Asn Thr Leu Pro Ala  Leu Asn Gln Ala Pro  Ser Ser His 
    2675                 2680                 2685             


Lys Cys  Ala Glu Ser Glu Gln  Lys 
    2690                 2695     


<210>  73
<211>  710
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Val Lys Leu Ala Lys Ala Gly Lys Asn Gln Gly Asp Pro Lys Lys 
1               5                   10                  15      


Met Ala Pro Pro Pro Lys Glu Val Glu Glu Asp Ser Glu Asp Glu Glu 
            20                  25                  30          


Met Ser Glu Asp Glu Glu Asp Asp Ser Ser Gly Glu Glu Val Val Ile 
        35                  40                  45              


Pro Gln Lys Lys Gly Lys Lys Ala Ala Ala Thr Ser Ala Lys Lys Val 
    50                  55                  60                  


Val Val Ser Pro Thr Lys Lys Val Ala Val Ala Thr Pro Ala Lys Lys 
65                  70                  75                  80  


Ala Ala Val Thr Pro Gly Lys Lys Ala Ala Ala Thr Pro Ala Lys Lys 
                85                  90                  95      


Thr Val Thr Pro Ala Lys Ala Val Thr Thr Pro Gly Lys Lys Gly Ala 
            100                 105                 110         


Thr Pro Gly Lys Ala Leu Val Ala Thr Pro Gly Lys Lys Gly Ala Ala 
        115                 120                 125             


Ile Pro Ala Lys Gly Ala Lys Asn Gly Lys Asn Ala Lys Lys Glu Asp 
    130                 135                 140                 


Ser Asp Glu Glu Glu Asp Asp Asp Ser Glu Glu Asp Glu Glu Asp Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Glu Asp Glu Asp Glu Ile Glu Pro Ala Ala Met Lys 
                165                 170                 175     


Ala Ala Ala Ala Ala Pro Ala Ser Glu Asp Glu Asp Asp Glu Asp Asp 
            180                 185                 190         


Glu Asp Asp Glu Asp Asp Asp Asp Asp Glu Glu Asp Asp Ser Glu Glu 
        195                 200                 205             


Glu Ala Met Glu Thr Thr Pro Ala Lys Gly Lys Lys Ala Ala Lys Val 
    210                 215                 220                 


Val Pro Val Lys Ala Lys Asn Val Ala Glu Asp Glu Asp Glu Glu Glu 
225                 230                 235                 240 


Asp Asp Glu Asp Glu Asp Asp Asp Asp Asp Glu Asp Asp Glu Asp Asp 
                245                 250                 255     


Asp Asp Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro 
            260                 265                 270         


Val Lys Glu Ala Pro Gly Lys Arg Lys Lys Glu Met Ala Lys Gln Lys 
        275                 280                 285             


Ala Ala Pro Glu Ala Lys Lys Gln Lys Val Glu Gly Thr Glu Pro Thr 
    290                 295                 300                 


Thr Ala Phe Asn Leu Phe Val Gly Asn Leu Asn Phe Asn Lys Ser Ala 
305                 310                 315                 320 


Pro Glu Leu Lys Thr Gly Ile Ser Asp Val Phe Ala Lys Asn Asp Leu 
                325                 330                 335     


Ala Val Val Asp Val Arg Ile Gly Met Thr Arg Lys Phe Gly Tyr Val 
            340                 345                 350         


Asp Phe Glu Ser Ala Glu Asp Leu Glu Lys Ala Leu Glu Leu Thr Gly 
        355                 360                 365             


Leu Lys Val Phe Gly Asn Glu Ile Lys Leu Glu Lys Pro Lys Gly Lys 
    370                 375                 380                 


Asp Ser Lys Lys Glu Arg Asp Ala Arg Thr Leu Leu Ala Lys Asn Leu 
385                 390                 395                 400 


Pro Tyr Lys Val Thr Gln Asp Glu Leu Lys Glu Val Phe Glu Asp Ala 
                405                 410                 415     


Ala Glu Ile Arg Leu Val Ser Lys Asp Gly Lys Ser Lys Gly Ile Ala 
            420                 425                 430         


Tyr Ile Glu Phe Lys Thr Glu Ala Asp Ala Glu Lys Thr Phe Glu Glu 
        435                 440                 445             


Lys Gln Gly Thr Glu Ile Asp Gly Arg Ser Ile Ser Leu Tyr Tyr Thr 
    450                 455                 460                 


Gly Glu Lys Gly Gln Asn Gln Asp Tyr Arg Gly Gly Lys Asn Ser Thr 
465                 470                 475                 480 


Trp Ser Gly Glu Ser Lys Thr Leu Val Leu Ser Asn Leu Ser Tyr Ser 
                485                 490                 495     


Ala Thr Glu Glu Thr Leu Gln Glu Val Phe Glu Lys Ala Thr Phe Ile 
            500                 505                 510         


Lys Val Pro Gln Asn Gln Asn Gly Lys Ser Lys Gly Tyr Ala Phe Ile 
        515                 520                 525             


Glu Phe Ala Ser Phe Glu Asp Ala Lys Glu Ala Leu Asn Ser Cys Asn 
    530                 535                 540                 


Lys Arg Glu Ile Glu Gly Arg Ala Ile Arg Leu Glu Leu Gln Gly Pro 
545                 550                 555                 560 


Arg Gly Ser Pro Asn Ala Arg Ser Gln Pro Ser Lys Thr Leu Phe Val 
                565                 570                 575     


Lys Gly Leu Ser Glu Asp Thr Thr Glu Glu Thr Leu Lys Glu Ser Phe 
            580                 585                 590         


Asp Gly Ser Val Arg Ala Arg Ile Val Thr Asp Arg Glu Thr Gly Ser 
        595                 600                 605             


Ser Lys Gly Phe Gly Phe Val Asp Phe Asn Ser Glu Glu Asp Ala Lys 
    610                 615                 620                 


Ala Ala Lys Glu Ala Met Glu Asp Gly Glu Ile Asp Gly Asn Lys Val 
625                 630                 635                 640 


Thr Leu Asp Trp Ala Lys Pro Lys Gly Glu Gly Gly Phe Gly Gly Arg 
                645                 650                 655     


Gly Gly Gly Arg Gly Gly Phe Gly Gly Arg Gly Gly Gly Arg Gly Gly 
            660                 665                 670         


Arg Gly Gly Phe Gly Gly Arg Gly Arg Gly Gly Phe Gly Gly Arg Gly 
        675                 680                 685             


Gly Phe Arg Gly Gly Arg Gly Gly Gly Gly Asp His Lys Pro Gln Gly 
    690                 695                 700                 


Lys Lys Thr Lys Phe Glu 
705                 710 


<210>  74
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ala Ser Lys Arg Ala Leu Val Ile Leu Ala Lys Gly Ala Glu Glu 
1               5                   10                  15      


Met Glu Thr Val Ile Pro Val Asp Val Met Arg Arg Ala Gly Ile Lys 
            20                  25                  30          


Val Thr Val Ala Gly Leu Ala Gly Lys Asp Pro Val Gln Cys Ser Arg 
        35                  40                  45              


Asp Val Val Ile Cys Pro Asp Ala Ser Leu Glu Asp Ala Lys Lys Glu 
    50                  55                  60                  


Gly Pro Tyr Asp Val Val Val Leu Pro Gly Gly Asn Leu Gly Ala Gln 
65                  70                  75                  80  


Asn Leu Ser Glu Ser Ala Ala Val Lys Glu Ile Leu Lys Glu Gln Glu 
                85                  90                  95      


Asn Arg Lys Gly Leu Ile Ala Ala Ile Cys Ala Gly Pro Thr Ala Leu 
            100                 105                 110         


Leu Ala His Glu Ile Gly Phe Gly Ser Lys Val Thr Thr His Pro Leu 
        115                 120                 125             


Ala Lys Asp Lys Met Met Asn Gly Gly His Tyr Thr Tyr Ser Glu Asn 
    130                 135                 140                 


Arg Val Glu Lys Asp Gly Leu Ile Leu Thr Ser Arg Gly Pro Gly Thr 
145                 150                 155                 160 


Ser Phe Glu Phe Ala Leu Ala Ile Val Glu Ala Leu Asn Gly Lys Glu 
                165                 170                 175     


Val Ala Ala Gln Val Lys Ala Pro Leu Val Leu Lys Asp 
            180                 185                 


<210>  75
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Leu Arg Leu Ser Glu Arg Asn Met Lys Val Leu Leu Ala Ala Ala 
1               5                   10                  15      


Leu Ile Ala Gly Ser Val Phe Phe Leu Leu Leu Pro Gly Pro Ser Ala 
            20                  25                  30          


Ala Asp Glu Lys Lys Lys Gly Pro Lys Val Thr Val Lys Val Tyr Phe 
        35                  40                  45              


Asp Leu Arg Ile Gly Asp Glu Asp Val Gly Arg Val Ile Phe Gly Leu 
    50                  55                  60                  


Phe Gly Lys Thr Val Pro Lys Thr Val Asp Asn Phe Val Ala Leu Ala 
65                  70                  75                  80  


Thr Gly Glu Lys Gly Phe Gly Tyr Lys Asn Ser Lys Phe His Arg Val 
                85                  90                  95      


Ile Lys Asp Phe Met Ile Gln Gly Gly Asp Phe Thr Arg Gly Asp Gly 
            100                 105                 110         


Thr Gly Gly Lys Ser Ile Tyr Gly Glu Arg Phe Pro Asp Glu Asn Phe 
        115                 120                 125             


Lys Leu Lys His Tyr Gly Pro Gly Trp Val Ser Met Ala Asn Ala Gly 
    130                 135                 140                 


Lys Asp Thr Asn Gly Ser Gln Phe Phe Ile Thr Thr Val Lys Thr Ala 
145                 150                 155                 160 


Trp Leu Asp Gly Lys His Val Val Phe Gly Lys Val Leu Glu Gly Met 
                165                 170                 175     


Glu Val Val Arg Lys Val Glu Ser Thr Lys Thr Asp Ser Arg Asp Lys 
            180                 185                 190         


Pro Leu Lys Asp Val Ile Ile Ala Asp Cys Gly Lys Ile Glu Val Glu 
        195                 200                 205             


Lys Pro Phe Ala Ile Ala Lys Glu 
    210                 215     


<210>  76
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Thr Thr Lys 
            660                 665                 670         


Ile Ile Thr Lys Val Val Glu Pro Lys Ile Lys Val Ile Glu Gly Ser 
        675                 680                 685             


Leu Gln Pro Ile Ile Lys Thr Glu Gly Pro Thr Leu Thr Lys Val Lys 
    690                 695                 700                 


Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys Glu Gly Glu Thr Ile 
705                 710                 715                 720 


Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys Lys Tyr Thr Lys Ile 
                725                 730                 735     


Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys Glu Thr Arg Glu Glu 
            740                 745                 750         


Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr Arg Ile Ser Thr Gly 
        755                 760                 765             


Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu Leu Gln Glu Glu Val 
    770                 775                 780                 


Thr Lys Val Thr Lys Phe Ile Glu Gly Gly Asp Gly His Leu Phe Glu 
785                 790                 795                 800 


Asp Glu Glu Ile Lys Arg Leu Leu Gln Gly Asp Thr Pro Val Arg Lys 
                805                 810                 815     


Leu Gln Ala Asn Lys Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu 
            820                 825                 830         


Gly Arg Ser Gln 
        835     


<210>  77
<211>  2346
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Ser Asn Gly Tyr Arg Thr Leu Ser Gln His Leu Asn Asp Leu Lys 
1               5                   10                  15      


Lys Glu Asn Phe Ser Leu Lys Leu Arg Ile Tyr Phe Leu Glu Glu Arg 
            20                  25                  30          


Met Gln Gln Lys Tyr Glu Ala Ser Arg Glu Asp Ile Tyr Lys Arg Asn 
        35                  40                  45              


Ile Glu Leu Lys Val Glu Val Glu Ser Leu Lys Arg Glu Leu Gln Asp 
    50                  55                  60                  


Lys Lys Gln His Leu Asp Lys Thr Trp Ala Asp Val Glu Asn Leu Asn 
65                  70                  75                  80  


Ser Gln Asn Glu Ala Glu Leu Arg Arg Gln Phe Glu Glu Arg Gln Gln 
                85                  90                  95      


Glu Thr Glu His Val Tyr Glu Leu Leu Glu Asn Lys Ile Gln Leu Leu 
            100                 105                 110         


Gln Glu Glu Ser Arg Leu Ala Lys Asn Glu Ala Ala Arg Met Ala Ala 
        115                 120                 125             


Leu Val Glu Ala Glu Lys Glu Cys Asn Leu Glu Leu Ser Glu Lys Leu 
    130                 135                 140                 


Lys Gly Val Thr Lys Asn Trp Glu Asp Val Pro Gly Asp Gln Val Lys 
145                 150                 155                 160 


Pro Asp Gln Tyr Thr Glu Ala Leu Ala Gln Arg Asp Lys Arg Ile Glu 
                165                 170                 175     


Glu Leu Asn Gln Ser Leu Ala Ala Gln Glu Arg Leu Val Glu Gln Leu 
            180                 185                 190         


Ser Arg Glu Lys Gln Gln Leu Leu His Leu Leu Glu Glu Pro Thr Ser 
        195                 200                 205             


Met Glu Val Gln Pro Met Thr Glu Glu Leu Leu Lys Gln Gln Lys Leu 
    210                 215                 220                 


Asn Ser His Glu Thr Thr Ile Thr Gln Gln Ser Val Ser Asp Ser His 
225                 230                 235                 240 


Leu Ala Glu Leu Gln Glu Lys Ile Gln Gln Thr Glu Ala Thr Asn Lys 
                245                 250                 255     


Ile Leu Gln Glu Lys Leu Asn Glu Met Ser Tyr Glu Leu Lys Cys Ala 
            260                 265                 270         


Gln Glu Ser Ser Gln Lys Gln Asp Gly Thr Ile Gln Asn Leu Lys Glu 
        275                 280                 285             


Thr Leu Lys Ser Arg Glu Arg Glu Thr Glu Glu Leu Tyr Gln Val Ile 
    290                 295                 300                 


Glu Gly Gln Asn Asp Thr Met Ala Lys Leu Arg Glu Met Leu His Gln 
305                 310                 315                 320 


Ser Gln Leu Gly Gln Leu His Ser Ser Glu Gly Thr Ser Pro Ala Gln 
                325                 330                 335     


Gln Gln Val Ala Leu Leu Asp Leu Gln Ser Ala Leu Phe Cys Ser Gln 
            340                 345                 350         


Leu Glu Ile Gln Lys Leu Gln Arg Val Val Arg Gln Lys Glu Arg Gln 
        355                 360                 365             


Leu Ala Asp Ala Lys Gln Cys Val Gln Phe Val Glu Ala Ala Ala His 
    370                 375                 380                 


Glu Ser Glu Gln Gln Lys Glu Ala Ser Trp Lys His Asn Gln Glu Leu 
385                 390                 395                 400 


Arg Lys Ala Leu Gln Gln Leu Gln Glu Glu Leu Gln Asn Lys Ser Gln 
                405                 410                 415     


Gln Leu Arg Ala Trp Glu Ala Glu Lys Tyr Asn Glu Ile Arg Thr Gln 
            420                 425                 430         


Glu Gln Asn Ile Gln His Leu Asn His Ser Leu Ser His Lys Glu Gln 
        435                 440                 445             


Leu Leu Gln Glu Phe Arg Glu Leu Leu Gln Tyr Arg Asp Asn Ser Asp 
    450                 455                 460                 


Lys Thr Leu Glu Ala Asn Glu Met Leu Leu Glu Lys Leu Arg Gln Arg 
465                 470                 475                 480 


Ile His Asp Lys Ala Val Ala Leu Glu Arg Ala Ile Asp Glu Lys Phe 
                485                 490                 495     


Ser Ala Leu Glu Glu Lys Glu Lys Glu Leu Arg Gln Leu Arg Leu Ala 
            500                 505                 510         


Val Arg Glu Arg Asp His Asp Leu Glu Arg Leu Arg Asp Val Leu Ser 
        515                 520                 525             


Ser Asn Glu Ala Thr Met Gln Ser Met Glu Ser Leu Leu Arg Ala Lys 
    530                 535                 540                 


Gly Leu Glu Val Glu Gln Leu Ser Thr Thr Cys Gln Asn Leu Gln Trp 
545                 550                 555                 560 


Leu Lys Glu Glu Met Glu Thr Lys Phe Ser Arg Trp Gln Lys Glu Gln 
                565                 570                 575     


Glu Ser Ile Ile Gln Gln Leu Gln Thr Ser Leu His Asp Arg Asn Lys 
            580                 585                 590         


Glu Val Glu Asp Leu Ser Ala Thr Leu Leu Cys Lys Leu Gly Pro Gly 
        595                 600                 605             


Gln Ser Glu Ile Ala Glu Glu Leu Cys Gln Arg Leu Gln Arg Lys Glu 
    610                 615                 620                 


Arg Met Leu Gln Asp Leu Leu Ser Asp Arg Asn Lys Gln Val Leu Glu 
625                 630                 635                 640 


His Glu Met Glu Ile Gln Gly Leu Leu Gln Ser Val Ser Thr Arg Glu 
                645                 650                 655     


Gln Glu Ser Gln Ala Ala Ala Glu Lys Leu Val Gln Ala Leu Met Glu 
            660                 665                 670         


Arg Asn Ser Glu Leu Gln Ala Leu Arg Gln Tyr Leu Gly Gly Arg Asp 
        675                 680                 685             


Ser Leu Met Ser Gln Ala Pro Ile Ser Asn Gln Gln Ala Glu Val Thr 
    690                 695                 700                 


Pro Thr Gly Cys Leu Gly Lys Gln Thr Asp Gln Gly Ser Met Gln Ile 
705                 710                 715                 720 


Pro Ser Arg Asp Asp Ser Thr Ser Leu Thr Ala Lys Glu Asp Val Ser 
                725                 730                 735     


Ile Pro Arg Ser Thr Leu Gly Asp Leu Asp Thr Val Ala Gly Leu Glu 
            740                 745                 750         


Lys Glu Leu Ser Asn Ala Lys Glu Glu Leu Glu Leu Met Ala Lys Lys 
        755                 760                 765             


Glu Arg Glu Ser Gln Met Glu Leu Ser Ala Leu Gln Ser Met Met Ala 
    770                 775                 780                 


Val Gln Glu Glu Glu Leu Gln Val Gln Ala Ala Asp Met Glu Ser Leu 
785                 790                 795                 800 


Thr Arg Asn Ile Gln Ile Lys Glu Asp Leu Ile Lys Asp Leu Gln Met 
                805                 810                 815     


Gln Leu Val Asp Pro Glu Asp Ile Pro Ala Met Glu Arg Leu Thr Gln 
            820                 825                 830         


Glu Val Leu Leu Leu Arg Glu Lys Val Ala Ser Val Glu Ser Gln Gly 
        835                 840                 845             


Gln Glu Ile Ser Gly Asn Arg Arg Gln Gln Leu Leu Leu Met Leu Glu 
    850                 855                 860                 


Gly Leu Val Asp Glu Arg Ser Arg Leu Asn Glu Ala Leu Gln Ala Glu 
865                 870                 875                 880 


Arg Gln Leu Tyr Ser Ser Leu Val Lys Phe His Ala His Pro Glu Ser 
                885                 890                 895     


Ser Glu Arg Asp Arg Thr Leu Gln Val Glu Leu Glu Gly Ala Gln Val 
            900                 905                 910         


Leu Arg Ser Arg Leu Glu Glu Val Leu Gly Arg Ser Leu Glu Arg Leu 
        915                 920                 925             


Asn Arg Leu Glu Thr Leu Ala Ala Ile Gly Gly Ala Ala Ala Gly Asp 
    930                 935                 940                 


Asp Thr Glu Asp Thr Ser Thr Glu Phe Thr Asp Ser Ile Glu Glu Glu 
945                 950                 955                 960 


Ala Ala His His Ser His Gln Gln Leu Val Lys Val Ala Leu Glu Lys 
                965                 970                 975     


Ser Leu Ala Thr Val Glu Thr Gln Asn Pro Ser Phe Ser Pro Pro Ser 
            980                 985                 990         


Pro Met Gly Gly Asp Ser Asn Arg  Cys Leu Gln Glu Glu  Met Leu His 
        995                 1000                 1005             


Leu Arg  Ala Glu Phe His Gln  His Leu Glu Glu Lys  Arg Lys Ala 
    1010                 1015                 1020             


Glu Glu  Glu Leu Lys Glu Leu  Lys Ala Gln Ile Glu  Glu Ala Gly 
    1025                 1030                 1035             


Phe Ser  Ser Val Ser His Ile  Arg Asn Thr Met Leu  Ser Leu Cys 
    1040                 1045                 1050             


Leu Glu  Asn Ala Glu Leu Lys  Glu Gln Met Gly Glu  Ala Met Ser 
    1055                 1060                 1065             


Asp Gly  Trp Glu Ile Glu Glu  Asp Lys Glu Lys Gly  Glu Val Met 
    1070                 1075                 1080             


Val Glu  Thr Val Val Thr Lys  Glu Gly Leu Ser Glu  Ser Ser Leu 
    1085                 1090                 1095             


Gln Ala  Glu Phe Arg Lys Leu  Gln Gly Lys Leu Lys  Asn Ala His 
    1100                 1105                 1110             


Asn Ile  Ile Asn Leu Leu Lys  Glu Gln Leu Val Leu  Ser Ser Lys 
    1115                 1120                 1125             


Glu Gly  Asn Ser Lys Leu Thr  Pro Glu Leu Leu Val  His Leu Thr 
    1130                 1135                 1140             


Ser Thr  Ile Glu Arg Ile Asn  Thr Glu Leu Val Gly  Ser Pro Gly 
    1145                 1150                 1155             


Lys His  Gln His Gln Glu Glu  Gly Asn Val Thr Val  Arg Pro Phe 
    1160                 1165                 1170             


Pro Arg  Pro Gln Ser Leu Asp  Leu Gly Ala Thr Phe  Thr Val Asp 
    1175                 1180                 1185             


Ala His  Gln Leu Asp Asn Gln  Ser Gln Pro Arg Asp  Pro Gly Pro 
    1190                 1195                 1200             


Gln Ser  Ala Phe Ser Leu Pro  Gly Ser Thr Gln His  Leu Arg Ser 
    1205                 1210                 1215             


Gln Leu  Ser Gln Cys Lys Gln  Arg Tyr Gln Asp Leu  Gln Glu Lys 
    1220                 1225                 1230             


Leu Leu  Leu Ser Glu Ala Thr  Val Phe Ala Gln Ala  Asn Glu Leu 
    1235                 1240                 1245             


Glu Lys  Tyr Arg Val Met Leu  Thr Gly Glu Ser Leu  Val Lys Gln 
    1250                 1255                 1260             


Asp Ser  Lys Gln Ile Gln Val  Asp Leu Gln Asp Leu  Gly Tyr Glu 
    1265                 1270                 1275             


Thr Cys  Gly Arg Ser Glu Asn  Glu Ala Glu Arg Glu  Glu Thr Thr 
    1280                 1285                 1290             


Ser Pro  Glu Cys Glu Glu His  Asn Ser Leu Lys Glu  Met Val Leu 
    1295                 1300                 1305             


Met Glu  Gly Leu Cys Ser Glu  Gln Gly Arg Arg Gly  Ser Thr Leu 
    1310                 1315                 1320             


Ala Ser  Ser Ser Glu Arg Lys  Pro Leu Glu Asn Gln  Leu Gly Lys 
    1325                 1330                 1335             


Gln Glu  Glu Phe Arg Val Tyr  Gly Lys Ser Glu Asn  Ile Leu Val 
    1340                 1345                 1350             


Leu Arg  Lys Asp Ile Lys Asp  Leu Lys Ala Gln Leu  Gln Asn Ala 
    1355                 1360                 1365             


Asn Lys  Val Ile Gln Asn Leu  Lys Ser Arg Val Arg  Ser Leu Ser 
    1370                 1375                 1380             


Val Thr  Ser Asp Tyr Ser Ser  Ser Leu Glu Arg Pro  Trp Lys Leu 
    1385                 1390                 1395             


Arg Ala  Val Gly Thr Leu Glu  Gly Ser Ser Pro His  Ser Val Pro 
    1400                 1405                 1410             


Asp Glu  Asp Glu Gly Trp Leu  Ser Asp Gly Thr Gly  Ala Phe Tyr 
    1415                 1420                 1425             


Ser Pro  Gly Leu Gln Ala Lys  Lys Asp Leu Glu Ser  Leu Ile Gln 
    1430                 1435                 1440             


Arg Val  Ser Gln Leu Glu Ala  Gln Leu Pro Lys Asn  Gly Leu Glu 
    1445                 1450                 1455             


Glu Lys  Leu Ala Glu Glu Leu  Arg Ser Ala Ser Trp  Pro Gly Lys 
    1460                 1465                 1470             


Tyr Asp  Ser Leu Ile Gln Asp  Gln Ala Arg Glu Leu  Ser Tyr Leu 
    1475                 1480                 1485             


Arg Gln  Lys Ile Arg Glu Gly  Arg Gly Ile Cys Tyr  Leu Ile Thr 
    1490                 1495                 1500             


Arg His  Ala Lys Asp Thr Val  Lys Ser Phe Glu Asp  Leu Leu Arg 
    1505                 1510                 1515             


Ser Asn  Asp Ile Asp Tyr Tyr  Leu Gly Gln Ser Phe  Arg Glu Gln 
    1520                 1525                 1530             


Leu Ala  Gln Gly Ser Gln Leu  Thr Glu Arg Leu Thr  Ser Lys Leu 
    1535                 1540                 1545             


Ser Thr  Lys Asp His Lys Ser  Glu Lys Asp Gln Ala  Gly Leu Glu 
    1550                 1555                 1560             


Pro Leu  Ala Leu Arg Leu Ser  Arg Glu Leu Gln Glu  Lys Glu Lys 
    1565                 1570                 1575             


Val Ile  Glu Val Leu Gln Ala  Lys Leu Asp Ala Arg  Ser Leu Thr 
    1580                 1585                 1590             


Pro Ser  Ser Ser His Ala Leu  Ser Asp Ser His Arg  Ser Pro Ser 
    1595                 1600                 1605             


Ser Thr  Ser Phe Leu Ser Asp  Glu Leu Glu Ala Cys  Ser Asp Met 
    1610                 1615                 1620             


Asp Ile  Val Ser Glu Tyr Thr  His Tyr Glu Glu Lys  Lys Ala Ser 
    1625                 1630                 1635             


Pro Ser  His Ser Asp Ser Ile  His His Ser Ser His  Ser Ala Val 
    1640                 1645                 1650             


Leu Ser  Ser Lys Pro Ser Ser  Thr Ser Ala Ser Gln  Gly Ala Lys 
    1655                 1660                 1665             


Ala Glu  Ser Asn Ser Asn Pro  Ile Ser Leu Pro Thr  Pro Gln Asn 
    1670                 1675                 1680             


Thr Pro  Lys Glu Ala Asn Gln  Ala His Ser Gly Phe  His Phe His 
    1685                 1690                 1695             


Ser Ile  Pro Lys Leu Ala Ser  Leu Pro Gln Ala Pro  Leu Pro Ser 
    1700                 1705                 1710             


Ala Pro  Ser Ser Phe Leu Pro  Phe Ser Pro Thr Gly  Pro Leu Leu 
    1715                 1720                 1725             


Leu Gly  Cys Cys Glu Thr Pro  Val Val Ser Leu Ala  Glu Ala Gln 
    1730                 1735                 1740             


Gln Glu  Leu Gln Met Leu Gln  Lys Gln Leu Gly Glu  Ser Ala Ser 
    1745                 1750                 1755             


Thr Val  Pro Pro Ala Ser Thr  Ala Thr Leu Leu Ser  Asn Asp Leu 
    1760                 1765                 1770             


Glu Ala  Asp Ser Ser Tyr Tyr  Leu Asn Ser Ala Gln  Pro His Ser 
    1775                 1780                 1785             


Pro Pro  Arg Gly Thr Ile Glu  Leu Gly Arg Ile Leu  Glu Pro Gly 
    1790                 1795                 1800             


Tyr Leu  Gly Ser Ser Gly Lys  Trp Asp Val Met Arg  Pro Gln Lys 
    1805                 1810                 1815             


Gly Ser  Val Ser Gly Asp Leu  Ser Ser Gly Ser Ser  Val Tyr Gln 
    1820                 1825                 1830             


Leu Asn  Ser Lys Pro Thr Gly  Ala Asp Leu Leu Glu  Glu His Leu 
    1835                 1840                 1845             


Gly Glu  Ile Arg Asn Leu Arg  Gln Arg Leu Glu Glu  Ser Ile Cys 
    1850                 1855                 1860             


Ile Asn  Asp Arg Leu Arg Glu  Gln Leu Glu His Arg  Leu Thr Ser 
    1865                 1870                 1875             


Thr Ala  Arg Gly Arg Gly Ser  Thr Ser Asn Phe Tyr  Ser Gln Gly 
    1880                 1885                 1890             


Leu Glu  Ser Ile Pro Gln Leu  Cys Asn Glu Asn Arg  Val Leu Arg 
    1895                 1900                 1905             


Glu Asp  Asn Arg Arg Leu Gln  Ala Gln Leu Ser His  Val Ser Arg 
    1910                 1915                 1920             


Glu His  Ser Gln Glu Thr Glu  Ser Leu Arg Glu Ala  Leu Leu Ser 
    1925                 1930                 1935             


Ser Arg  Ser His Leu Gln Glu  Leu Glu Lys Glu Leu  Glu His Gln 
    1940                 1945                 1950             


Lys Val  Glu Arg Gln Gln Leu  Leu Glu Asp Leu Arg  Glu Lys Gln 
    1955                 1960                 1965             


Gln Glu  Val Leu His Phe Arg  Glu Glu Arg Leu Ser  Leu Gln Glu 
    1970                 1975                 1980             


Asn Asp  Ser Arg Leu Gln His  Lys Leu Val Leu Leu  Gln Gln Gln 
    1985                 1990                 1995             


Cys Glu  Glu Lys Gln Gln Leu  Phe Glu Ser Leu Gln  Ser Glu Leu 
    2000                 2005                 2010             


Gln Ile  Tyr Glu Ala Leu Tyr  Gly Asn Ser Lys Lys  Gly Leu Lys 
    2015                 2020                 2025             


Ala Tyr  Ser Leu Asp Ala Cys  His Gln Ile Pro Leu  Ser Ser Asp 
    2030                 2035                 2040             


Leu Ser  His Leu Val Ala Glu  Val Arg Ala Leu Arg  Gly Gln Leu 
    2045                 2050                 2055             


Glu Gln  Ser Ile Gln Gly Asn  Asn Cys Leu Arg Leu  Gln Leu Gln 
    2060                 2065                 2070             


Gln Gln  Leu Glu Ser Gly Ala  Gly Lys Ala Ser Leu  Ser Pro Ser 
    2075                 2080                 2085             


Ser Ile  Asn Gln Asn Phe Pro  Ala Ser Thr Asp Pro  Gly Asn Lys 
    2090                 2095                 2100             


Gln Leu  Leu Leu Gln Asp Ser  Ala Val Ser Pro Pro  Val Arg Asp 
    2105                 2110                 2115             


Val Gly  Met Asn Ser Pro Ala  Leu Val Phe Pro Ser  Ser Ala Ser 
    2120                 2125                 2130             


Ser Thr  Pro Gly Ser Glu Thr  Pro Ile Ile Asn Arg  Ala Asn Gly 
    2135                 2140                 2145             


Leu Gly  Leu Asp Thr Ser Pro  Val Met Lys Thr Pro  Pro Lys Leu 
    2150                 2155                 2160             


Glu Gly  Asp Ala Thr Asp Gly  Ser Phe Ala Asn Lys  His Gly Arg 
    2165                 2170                 2175             


His Val  Ile Gly His Ile Asp  Asp Tyr Ser Ala Leu  Arg Gln Gln 
    2180                 2185                 2190             


Ile Ala  Glu Gly Lys Leu Leu  Val Lys Lys Ile Val  Ser Leu Val 
    2195                 2200                 2205             


Arg Ser  Ala Cys Ser Phe Pro  Gly Leu Glu Ala Gln  Gly Thr Glu 
    2210                 2215                 2220             


Val Leu  Gly Ser Lys Gly Ile  His Glu Leu Arg Ser  Ser Thr Ser 
    2225                 2230                 2235             


Ala Leu  His His Ala Leu Glu  Glu Ser Ala Ser Leu  Leu Thr Met 
    2240                 2245                 2250             


Phe Trp  Arg Ala Ala Leu Pro  Ser Thr His Ile Pro  Val Leu Pro 
    2255                 2260                 2265             


Gly Lys  Val Gly Glu Ser Thr  Glu Arg Glu Leu Leu  Glu Leu Arg 
    2270                 2275                 2280             


Thr Lys  Val Ser Lys Gln Glu  Arg Leu Leu Gln Ser  Thr Thr Glu 
    2285                 2290                 2295             


His Leu  Lys Asn Ala Asn Gln  Gln Lys Glu Ser Met  Glu Gln Phe 
    2300                 2305                 2310             


Ile Val  Ser Gln Leu Thr Arg  Thr His Asp Val Leu  Lys Lys Ala 
    2315                 2320                 2325             


Arg Thr  Asn Leu Glu Val Lys  Ser Leu Arg Ala Leu  Pro Cys Thr 
    2330                 2335                 2340             


Pro Ala  Leu 
    2345     


<210>  78
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Ala Gln Asn Leu Lys Asp Leu Ala Gly Arg Leu Pro Ala Gly Pro 
1               5                   10                  15      


Arg Gly Met Gly Thr Ala Leu Lys Leu Leu Leu Gly Ala Gly Ala Val 
            20                  25                  30          


Ala Tyr Gly Val Arg Glu Ser Val Phe Thr Val Glu Gly Gly His Arg 
        35                  40                  45              


Ala Ile Phe Phe Asn Arg Ile Gly Gly Val Gln Gln Asp Thr Ile Leu 
    50                  55                  60                  


Ala Glu Gly Leu His Phe Arg Ile Pro Trp Phe Gln Tyr Pro Ile Ile 
65                  70                  75                  80  


Tyr Asp Ile Arg Ala Arg Pro Arg Lys Ile Ser Ser Pro Thr Gly Ser 
                85                  90                  95      


Lys Asp Leu Gln Met Val Asn Ile Ser Leu Arg Val Leu Ser Arg Pro 
            100                 105                 110         


Asn Ala Gln Glu Leu Pro Ser Met Tyr Gln Arg Leu Gly Leu Asp Tyr 
        115                 120                 125             


Glu Glu Arg Val Leu Pro Ser Ile Val Asn Glu Val Leu Lys Ser Val 
    130                 135                 140                 


Val Ala Lys Phe Asn Ala Ser Gln Leu Ile Thr Gln Arg Ala Gln Val 
145                 150                 155                 160 


Ser Leu Leu Ile Arg Arg Glu Leu Thr Glu Arg Ala Lys Asp Phe Ser 
                165                 170                 175     


Leu Ile Leu Asp Asp Val Ala Ile Thr Glu Leu Ser Phe Ser Arg Glu 
            180                 185                 190         


Tyr Thr Ala Ala Val Glu Ala Lys Gln Val Ala Gln Gln Glu Ala Gln 
        195                 200                 205             


Arg Ala Gln Phe Leu Val Glu Lys Ala Lys Gln Glu Gln Arg Gln Lys 
    210                 215                 220                 


Ile Val Gln Ala Glu Gly Glu Ala Glu Ala Ala Lys Met Leu Gly Glu 
225                 230                 235                 240 


Ala Leu Ser Lys Asn Pro Gly Tyr Ile Lys Leu Arg Lys Ile Arg Ala 
                245                 250                 255     


Ala Gln Asn Ile Ser Lys Thr Ile Ala Thr Ser Gln Asn Arg Ile Tyr 
            260                 265                 270         


Leu Thr Ala Asp Asn Leu Val Leu Asn Leu Gln Asp Glu Ser Phe Thr 
        275                 280                 285             


Arg Gly Ser Asp Ser Leu Ile Lys Gly Lys Lys 
    290                 295                 


<210>  79
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Ser Gly Glu Asp Glu Gln Gln Glu Gln Thr Ile Ala Glu Asp Leu 
1               5                   10                  15      


Val Val Thr Lys Tyr Lys Met Gly Gly Asp Ile Ala Asn Arg Val Leu 
            20                  25                  30          


Arg Ser Leu Val Glu Ala Ser Ser Ser Gly Val Ser Val Leu Ser Leu 
        35                  40                  45              


Cys Glu Lys Gly Asp Ala Met Ile Met Glu Glu Thr Gly Lys Ile Phe 
    50                  55                  60                  


Lys Lys Glu Lys Glu Met Lys Lys Gly Ile Ala Phe Pro Thr Ser Ile 
65                  70                  75                  80  


Ser Val Asn Asn Cys Val Cys His Phe Ser Pro Leu Lys Ser Asp Gln 
                85                  90                  95      


Asp Tyr Ile Leu Lys Glu Gly Asp Leu Val Lys Ile Asp Leu Gly Val 
            100                 105                 110         


His Val Asp Gly Phe Ile Ala Asn Val Ala His Thr Phe Val Val Asp 
        115                 120                 125             


Val Ala Gln Gly Thr Gln Val Thr Gly Arg Lys Ala Asp Val Ile Lys 
    130                 135                 140                 


Ala Ala His Leu Cys Ala Glu Ala Ala Leu Arg Leu Val Lys Pro Gly 
145                 150                 155                 160 


Asn Gln Asn Thr Gln Val Thr Glu Ala Trp Asn Lys Val Ala His Ser 
                165                 170                 175     


Phe Asn Cys Thr Pro Ile Glu Gly Met Leu Ser His Gln Leu Lys Gln 
            180                 185                 190         


His Val Ile Asp Gly Glu Lys Thr Ile Ile Gln Asn Pro Thr Asp Gln 
        195                 200                 205             


Gln Lys Lys Asp His Glu Lys Ala Glu Phe Glu Val His Glu Val Tyr 
    210                 215                 220                 


Ala Val Asp Val Leu Val Ser Ser Gly Glu Gly Lys Ala Lys Asp Ala 
225                 230                 235                 240 


Gly Gln Arg Thr Thr Ile Tyr Lys Arg Asp Pro Ser Lys Gln Tyr Gly 
                245                 250                 255     


Leu Lys Met Lys Thr Ser Arg Ala Phe Phe Ser Glu Val Glu Arg Arg 
            260                 265                 270         


Phe Asp Ala Met Pro Phe Thr Leu Arg Ala Phe Glu Asp Glu Lys Lys 
        275                 280                 285             


Ala Arg Met Gly Val Val Glu Cys Ala Lys His Glu Leu Leu Gln Pro 
    290                 295                 300                 


Phe Asn Val Leu Tyr Glu Lys Glu Gly Glu Phe Val Ala Gln Phe Lys 
305                 310                 315                 320 


Phe Thr Val Leu Leu Met Pro Asn Gly Pro Met Arg Ile Thr Ser Gly 
                325                 330                 335     


Pro Phe Glu Pro Asp Leu Tyr Lys Ser Glu Met Glu Val Gln Asp Ala 
            340                 345                 350         


Glu Leu Lys Ala Leu Leu Gln Ser Ser Ala Ser Arg Lys Thr Gln Lys 
        355                 360                 365             


Lys Lys Lys Lys Lys Ala Ser Lys Thr Ala Glu Asn Ala Thr Ser Gly 
    370                 375                 380                 


Glu Thr Leu Glu Glu Asn Glu Ala Gly Asp 
385                 390                 


<210>  80
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Val Arg Thr Lys Thr Trp Thr Leu Lys Lys His Phe Val Gly Tyr 
1               5                   10                  15      


Pro Thr Asn Ser Asp Phe Glu Leu Lys Thr Ala Glu Leu Pro Pro Leu 
            20                  25                  30          


Lys Asn Gly Glu Val Leu Leu Glu Ala Leu Phe Leu Thr Val Asp Pro 
        35                  40                  45              


Tyr Met Arg Val Ala Ala Lys Arg Leu Lys Glu Gly Asp Thr Met Met 
    50                  55                  60                  


Gly Gln Gln Val Ala Lys Val Val Glu Ser Lys Asn Val Ala Leu Pro 
65                  70                  75                  80  


Lys Gly Thr Ile Val Leu Ala Ser Pro Gly Trp Thr Thr His Ser Ile 
                85                  90                  95      


Ser Asp Gly Lys Asp Leu Glu Lys Leu Leu Thr Glu Trp Pro Asp Thr 
            100                 105                 110         


Ile Pro Leu Ser Leu Ala Leu Gly Thr Val Gly Met Pro Gly Leu Thr 
        115                 120                 125             


Ala Tyr Phe Gly Leu Leu Glu Ile Cys Gly Val Lys Gly Gly Glu Thr 
    130                 135                 140                 


Val Met Val Asn Ala Ala Ala Gly Ala Val Gly Ser Val Val Gly Gln 
145                 150                 155                 160 


Ile Ala Lys Leu Lys Gly Cys Lys Val Val Gly Ala Val Gly Ser Asp 
                165                 170                 175     


Glu Lys Val Ala Tyr Leu Gln Lys Leu Gly Phe Asp Val Val Phe Asn 
            180                 185                 190         


Tyr Lys Thr Val Glu Ser Leu Glu Glu Thr Leu Lys Lys Ala Ser Pro 
        195                 200                 205             


Asp Gly Tyr Asp Cys Tyr Phe Asp Asn Val Gly Gly Glu Phe Ser Asn 
    210                 215                 220                 


Thr Val Ile Gly Gln Met Lys Lys Phe Gly Arg Ile Ala Ile Cys Gly 
225                 230                 235                 240 


Ala Ile Ser Thr Tyr Asn Arg Thr Gly Pro Leu Pro Pro Gly Pro Pro 
                245                 250                 255     


Pro Glu Ile Val Ile Tyr Gln Glu Leu Arg Met Glu Ala Phe Val Val 
            260                 265                 270         


Tyr Arg Trp Gln Gly Asp Ala Arg Gln Lys Ala Leu Lys Asp Leu Leu 
        275                 280                 285             


Lys Trp Val Leu Glu Gly Lys Ile Gln Tyr Lys Glu Tyr Ile Ile Glu 
    290                 295                 300                 


Gly Phe Glu Asn Met Pro Ala Ala Phe Met Gly Met Leu Lys Gly Asp 
305                 310                 315                 320 


Asn Leu Gly Lys Thr Ile Val Lys Ala 
                325                 


<210>  81
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ala Ala Gln Ala Leu Ala Leu Leu Arg Glu Val Ala Arg Leu Glu 
1               5                   10                  15      


Ala Pro Leu Glu Glu Leu Arg Ala Leu His Ser Val Leu Gln Ala Val 
            20                  25                  30          


Pro Leu Asn Glu Leu Arg Gln Gln Ala Ala Glu Leu Arg Leu Gly Pro 
        35                  40                  45              


Leu Phe Ser Leu Leu Asn Glu Asn His Arg Glu Lys Thr Thr Leu Cys 
    50                  55                  60                  


Val Ser Ile Leu Glu Arg Leu Leu Gln Ala Met Glu Pro Val His Val 
65                  70                  75                  80  


Ala Arg Asn Leu Arg Val Asp Leu Gln Arg Gly Leu Ile His Pro Asp 
                85                  90                  95      


Asp Ser Val Lys Ile Leu Thr Leu Ser Gln Ile Gly Arg Ile Val Glu 
            100                 105                 110         


Asn Ser Asp Ala Val Thr Glu Ile Leu Asn Asn Ala Glu Leu Leu Lys 
        115                 120                 125             


Gln Ile Val Tyr Cys Ile Gly Gly Glu Asn Leu Ser Val Ala Lys Ala 
    130                 135                 140                 


Ala Ile Lys Ser Leu Ser Arg Ile Ser Leu Thr Gln Ala Gly Leu Glu 
145                 150                 155                 160 


Ala Leu Phe Glu Ser Asn Leu Leu Asp Asp Leu Lys Ser Val Met Lys 
                165                 170                 175     


Thr Asn Asp Ile Val Arg Tyr Arg Val Tyr Glu Leu Ile Ile Glu Ile 
            180                 185                 190         


Ser Ser Val Ser Pro Glu Ser Leu Asn Tyr Cys Thr Thr Ser Gly Leu 
        195                 200                 205             


Val Thr Gln Leu Leu Arg Glu Leu Thr Gly Glu Asp Val Leu Val Arg 
    210                 215                 220                 


Ala Thr Cys Ile Glu Met Val Thr Ser Leu Ala Tyr Thr His His Gly 
225                 230                 235                 240 


Arg Gln Tyr Leu Ala Gln Glu Gly Val Ile Asp Gln Ile Ser Asn Ile 
                245                 250                 255     


Ile Val Gly Ala Asp Ser Asp Pro Phe Ser Ser Phe Tyr Leu Pro Gly 
            260                 265                 270         


Phe Val Lys Phe Phe Gly Asn Leu Ala Val Met Asp Ser Pro Gln Gln 
        275                 280                 285             


Ile Cys Glu Arg Tyr Pro Ile Phe Val Glu Lys Val Phe Glu Met Ile 
    290                 295                 300                 


Glu Ser Gln Asp Pro Thr Met Ile Gly Val Ala Val Asp Thr Val Gly 
305                 310                 315                 320 


Ile Leu Gly Ser Asn Val Glu Gly Lys Gln Val Leu Gln Lys Thr Gly 
                325                 330                 335     


Thr Arg Phe Glu Arg Leu Leu Met Arg Ile Gly His Gln Ser Lys Asn 
            340                 345                 350         


Ala Pro Val Glu Leu Lys Ile Arg Cys Leu Asp Ala Ile Ser Ser Leu 
        355                 360                 365             


Leu Tyr Leu Pro Pro Glu Gln Gln Thr Asp Asp Leu Leu Arg Met Thr 
    370                 375                 380                 


Glu Ser Trp Phe Ser Ser Leu Ser Arg Asp Pro Leu Glu Leu Phe Arg 
385                 390                 395                 400 


Gly Ile Ser Ser Gln Pro Phe Pro Glu Leu His Cys Ala Ala Leu Lys 
                405                 410                 415     


Val Phe Thr Ala Ile Ala Asn Gln Pro Trp Ala Gln Lys Leu Met Phe 
            420                 425                 430         


Asn Ser Pro Gly Phe Val Glu Tyr Val Val Asp Arg Ser Val Glu His 
        435                 440                 445             


Asp Lys Ala Ser Lys Asp Ala Lys Tyr Glu Leu Val Lys Ala Leu Ala 
    450                 455                 460                 


Asn Ser Lys Thr Ile Ala Glu Ile Phe Gly Asn Pro Asn Tyr Leu Arg 
465                 470                 475                 480 


Leu Arg Thr Tyr Leu Ser Glu Gly Pro Tyr Tyr Val Lys Pro Val Ser 
                485                 490                 495     


Thr Thr Ala Val Glu Gly Ala Glu 
            500                 


<210>  82
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Ser Ile Met Ser Tyr Asn Gly Gly Ala Val Met Ala Met Lys Gly 
1               5                   10                  15      


Lys Asn Cys Val Ala Ile Ala Ala Asp Arg Arg Phe Gly Ile Gln Ala 
            20                  25                  30          


Gln Met Val Thr Thr Asp Phe Gln Lys Ile Phe Pro Met Gly Asp Arg 
        35                  40                  45              


Leu Tyr Ile Gly Leu Ala Gly Leu Ala Thr Asp Val Gln Thr Val Ala 
    50                  55                  60                  


Gln Arg Leu Lys Phe Arg Leu Asn Leu Tyr Glu Leu Lys Glu Gly Arg 
65                  70                  75                  80  


Gln Ile Lys Pro Tyr Thr Leu Met Ser Met Val Ala Asn Leu Leu Tyr 
                85                  90                  95      


Glu Lys Arg Phe Gly Pro Tyr Tyr Thr Glu Pro Val Ile Ala Gly Leu 
            100                 105                 110         


Asp Pro Lys Thr Phe Lys Pro Phe Ile Cys Ser Leu Asp Leu Ile Gly 
        115                 120                 125             


Cys Pro Met Val Thr Asp Asp Phe Val Val Ser Gly Thr Cys Ala Glu 
    130                 135                 140                 


Gln Met Tyr Gly Met Cys Glu Ser Leu Trp Glu Pro Asn Met Asp Pro 
145                 150                 155                 160 


Asp His Leu Phe Glu Thr Ile Ser Gln Ala Met Leu Asn Ala Val Asp 
                165                 170                 175     


Arg Asp Ala Val Ser Gly Met Gly Val Ile Val His Ile Ile Glu Lys 
            180                 185                 190         


Asp Lys Ile Thr Thr Arg Thr Leu Lys Ala Arg Met Asp 
        195                 200                 205 


<210>  83
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 
            20                  25                  30          


Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met 
        35                  40                  45              


Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala 
    50                  55                  60                  


Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu 
65                  70                  75                  80  


Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly 
                85                  90                  95      


Val Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala 
            100                 105                 110         


Gly Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu 
        115                 120                 125             


Lys Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu 
    130                 135                 140                 


Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Ile Val Gly Phe Phe 
145                 150                 155                 160 


Asp Asp Ser Phe Ser Glu Ala His Ser Glu Phe Leu Lys Ala Ala Ser 
                165                 170                 175     


Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Val Glu Ser Leu 
            180                 185                 190         


Val Asn Glu Tyr Asp Asp Asn Gly Glu Gly Ile Ile Leu Phe Arg Pro 
        195                 200                 205             


Ser His Leu Thr Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu 
    210                 215                 220                 


Gln Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Glu Asn Ile 
225                 230                 235                 240 


Phe Gly Ile Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln 
                245                 250                 255     


Gly Lys Asp Leu Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn 
            260                 265                 270         


Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys 
        275                 280                 285             


Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg 
    290                 295                 300                 


Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala 
305                 310                 315                 320 


Gly Glu Ile Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe 
                325                 330                 335     


Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe 
            340                 345                 350         


Leu Gln Asp Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu 
        355                 360                 365             


Pro Ile Pro Glu Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu 
    370                 375                 380                 


Asn Phe Asp Glu Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu 
385                 390                 395                 400 


Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr 
                405                 410                 415     


Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala 
            420                 425                 430         


Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg 
        435                 440                 445             


Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro 
    450                 455                 460                 


Lys Lys Tyr Glu Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu 
465                 470                 475                 480 


Gln Arg Glu Ala Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys 
                485                 490                 495     


Lys Lys Lys Lys Ala Gln Glu Asp Leu 
            500                 505 


<210>  84
<211>  531
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln 
1               5                   10                  15      


Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg 
            20                  25                  30          


Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile 
        35                  40                  45              


Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met 
    50                  55                  60                  


Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr 
65                  70                  75                  80  


His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu 
                85                  90                  95      


Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu 
            100                 105                 110         


Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly 
        115                 120                 125             


Thr Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu 
    130                 135                 140                 


Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp 
145                 150                 155                 160 


Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val 
                165                 170                 175     


Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe 
            180                 185                 190         


Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly 
        195                 200                 205             


Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys 
    210                 215                 220                 


Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val 
225                 230                 235                 240 


Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys 
                245                 250                 255     


Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu 
            260                 265                 270         


Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp 
        275                 280                 285             


Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu 
    290                 295                 300                 


Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala 
305                 310                 315                 320 


Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys 
                325                 330                 335     


Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val 
            340                 345                 350         


Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly 
        355                 360                 365             


Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu 
    370                 375                 380                 


Ala Glu Ala Ala Ile Tyr His Leu Gln Leu Phe Glu Glu Leu Arg Arg 
385                 390                 395                 400 


Leu Ala Pro Ile Thr Ser Asp Pro Thr Glu Ala Thr Ala Val Gly Ala 
                405                 410                 415     


Val Glu Ala Ser Phe Lys Cys Cys Ser Gly Ala Ile Ile Val Leu Thr 
            420                 425                 430         


Lys Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala 
        435                 440                 445             


Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His 
    450                 455                 460                 


Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu 
465                 470                 475                 480 


Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val 
                485                 490                 495     


Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu 
            500                 505                 510         


Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val 
        515                 520                 525             


Pro Val Pro 
    530     


<210>  85
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Thr Glu Lys Ala Pro Glu Pro His Val Glu Glu Asp Asp Asp Asp 
1               5                   10                  15      


Glu Leu Asp Ser Lys Leu Asn Tyr Lys Pro Pro Pro Gln Lys Ser Leu 
            20                  25                  30          


Lys Glu Leu Gln Glu Met Asp Lys Asp Asp Glu Ser Leu Ile Lys Tyr 
        35                  40                  45              


Lys Lys Thr Leu Leu Gly Asp Gly Pro Val Val Thr Asp Pro Lys Ala 
    50                  55                  60                  


Pro Asn Val Val Val Thr Arg Leu Thr Leu Val Cys Glu Ser Ala Pro 
65                  70                  75                  80  


Gly Pro Ile Thr Met Asp Leu Thr Gly Asp Leu Glu Ala Leu Lys Lys 
                85                  90                  95      


Glu Thr Ile Val Leu Lys Glu Gly Ser Glu Tyr Arg Val Lys Ile His 
            100                 105                 110         


Phe Lys Val Asn Arg Asp Ile Val Ser Gly Leu Lys Tyr Val Gln His 
        115                 120                 125             


Thr Tyr Arg Thr Gly Val Lys Val Asp Lys Ala Thr Phe Met Val Gly 
    130                 135                 140                 


Ser Tyr Gly Pro Arg Pro Glu Glu Tyr Glu Phe Leu Thr Pro Val Glu 
145                 150                 155                 160 


Glu Ala Pro Lys Gly Met Leu Ala Arg Gly Thr Tyr His Asn Lys Ser 
                165                 170                 175     


Phe Phe Thr Asp Asp Asp Lys Gln Asp His Leu Ser Trp Glu Trp Asn 
            180                 185                 190         


Leu Ser Ile Lys Lys Glu Trp Thr Glu 
        195                 200     


<210>  86
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Gln Arg Pro Gly Pro Phe Ser Thr Leu Tyr Gly Arg Val Leu Ala 
1               5                   10                  15      


Pro Leu Pro Gly Arg Ala Gly Gly Ala Ala Ser Gly Gly Gly Gly Asn 
            20                  25                  30          


Ser Trp Asp Leu Pro Gly Ser His Val Arg Leu Pro Gly Arg Ala Gln 
        35                  40                  45              


Ser Gly Thr Arg Gly Gly Ala Gly Asn Thr Ser Thr Ser Cys Gly Asp 
    50                  55                  60                  


Ser Asn Ser Ile Cys Pro Ala Pro Ser Thr Met Ser Lys Ala Glu Glu 
65                  70                  75                  80  


Ala Lys Lys Leu Ala Gly Arg Ala Ala Val Glu Asn His Val Arg Asn 
                85                  90                  95      


Asn Gln Val Leu Gly Ile Gly Ser Gly Ser Thr Ile Val His Ala Val 
            100                 105                 110         


Gln Arg Ile Ala Glu Arg Val Lys Gln Glu Asn Leu Asn Leu Val Cys 
        115                 120                 125             


Ile Pro Thr Ser Phe Gln Ala Arg Gln Leu Ile Leu Gln Tyr Gly Leu 
    130                 135                 140                 


Thr Leu Ser Asp Leu Asp Arg His Pro Glu Ile Asp Leu Ala Ile Asp 
145                 150                 155                 160 


Gly Ala Asp Glu Val Asp Ala Asp Leu Asn Leu Ile Lys Gly Gly Gly 
                165                 170                 175     


Gly Cys Leu Thr Gln Glu Lys Ile Val Ala Gly Tyr Ala Ser Arg Phe 
            180                 185                 190         


Ile Val Ile Ala Asp Phe Arg Lys Asp Ser Lys Asn Leu Gly Asp Gln 
        195                 200                 205             


Trp His Lys Gly Ile Pro Ile Glu Val Ile Pro Met Ala Tyr Val Pro 
    210                 215                 220                 


Val Ser Arg Ala Val Ser Gln Lys Phe Gly Gly Val Val Glu Leu Arg 
225                 230                 235                 240 


Met Ala Val Asn Lys Ala Gly Pro Val Val Thr Asp Asn Gly Asn Phe 
                245                 250                 255     


Ile Leu Asp Trp Lys Phe Asp Arg Val His Lys Trp Ser Glu Val Asn 
            260                 265                 270         


Thr Ala Ile Lys Met Ile Pro Gly Val Val Asp Thr Gly Leu Phe Ile 
        275                 280                 285             


Asn Met Ala Glu Arg Val Tyr Phe Gly Met Gln Asp Gly Ser Val Asn 
    290                 295                 300                 


Met Arg Glu Lys Pro Phe Cys 
305                 310     


<210>  87
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Ala Cys Ala Arg Pro Leu Ile Ser Val Tyr Ser Glu Lys Gly Glu 
1               5                   10                  15      


Ser Ser Gly Lys Asn Val Thr Leu Pro Ala Val Phe Lys Ala Pro Ile 
            20                  25                  30          


Arg Pro Asp Ile Val Asn Phe Val His Thr Asn Leu Arg Lys Asn Asn 
        35                  40                  45              


Arg Gln Pro Tyr Ala Val Ser Glu Leu Ala Gly His Gln Thr Ser Ala 
    50                  55                  60                  


Glu Ser Trp Gly Thr Gly Arg Ala Val Ala Arg Ile Pro Arg Val Arg 
65                  70                  75                  80  


Gly Gly Gly Thr His Arg Ser Gly Gln Gly Ala Phe Gly Asn Met Cys 
                85                  90                  95      


Arg Gly Gly Arg Met Phe Ala Pro Thr Lys Thr Trp Arg Arg Trp His 
            100                 105                 110         


Arg Arg Val Asn Thr Thr Gln Lys Arg Tyr Ala Ile Cys Ser Ala Leu 
        115                 120                 125             


Ala Ala Ser Ala Leu Pro Ala Leu Val Met Ser Lys Gly His Arg Ile 
    130                 135                 140                 


Glu Glu Val Pro Glu Leu Pro Leu Val Val Glu Asp Lys Val Glu Gly 
145                 150                 155                 160 


Tyr Lys Lys Thr Lys Glu Ala Val Leu Leu Leu Lys Lys Leu Lys Ala 
                165                 170                 175     


Trp Asn Asp Ile Lys Lys Val Tyr Ala Ser Gln Arg Met Arg Ala Gly 
            180                 185                 190         


Lys Gly Lys Met Arg Asn Arg Arg Arg Ile Gln Arg Arg Gly Pro Cys 
        195                 200                 205             


Ile Ile Tyr Asn Glu Asp Asn Gly Ile Ile Lys Ala Phe Arg Asn Ile 
    210                 215                 220                 


Pro Gly Ile Thr Leu Leu Asn Val Ser Lys Leu Asn Ile Leu Lys Leu 
225                 230                 235                 240 


Ala Pro Gly Gly His Val Gly Arg Phe Cys Ile Trp Thr Glu Ser Ala 
                245                 250                 255     


Phe Arg Lys Leu Asp Glu Leu Tyr Gly Thr Trp Arg Lys Ala Ala Ser 
            260                 265                 270         


Leu Lys Ser Asn Tyr Asn Leu Pro Met His Lys Met Ile Asn Thr Asp 
        275                 280                 285             


Leu Ser Arg Ile Leu Lys Ser Pro Glu Ile Gln Arg Ala Leu Arg Ala 
    290                 295                 300                 


Pro Arg Lys Lys Ile His Arg Arg Val Leu Lys Lys Asn Pro Leu Lys 
305                 310                 315                 320 


Asn Leu Arg Ile Met Leu Lys Leu Asn Pro Tyr Ala Lys Thr Met Arg 
                325                 330                 335     


Arg Asn Thr Ile Leu Arg Gln Ala Arg Asn His Lys Leu Arg Val Asp 
            340                 345                 350         


Lys Ala Ala Ala Ala Ala Ala Ala Leu Gln Ala Lys Ser Asp Glu Lys 
        355                 360                 365             


Ala Ala Val Ala Gly Lys Lys Pro Val Val Gly Lys Lys Gly Lys Lys 
    370                 375                 380                 


Ala Ala Val Gly Val Lys Lys Gln Lys Lys Pro Leu Val Gly Lys Lys 
385                 390                 395                 400 


Ala Ala Ala Thr Lys Lys Pro Ala Pro Glu Lys Lys Pro Ala Glu Lys 
                405                 410                 415     


Lys Pro Thr Thr Glu Glu Lys Lys Pro Ala Ala 
            420                 425         


<210>  88
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Pro Ser Lys Gly Pro Leu Gln Ser Val Gln Val Phe Gly Arg Lys 
1               5                   10                  15      


Lys Thr Ala Thr Ala Val Ala His Cys Lys Arg Gly Asn Gly Leu Ile 
            20                  25                  30          


Lys Val Asn Gly Arg Pro Leu Glu Met Ile Glu Pro Arg Thr Leu Gln 
        35                  40                  45              


Tyr Lys Leu Leu Glu Pro Val Leu Leu Leu Gly Lys Glu Arg Phe Ala 
    50                  55                  60                  


Gly Val Asp Ile Arg Val Arg Val Lys Gly Gly Gly His Val Ala Gln 
65                  70                  75                  80  


Ile Tyr Ala Ile Arg Gln Ser Ile Ser Lys Ala Leu Val Ala Tyr Tyr 
                85                  90                  95      


Gln Lys Tyr Val Asp Glu Ala Ser Lys Lys Glu Ile Lys Asp Ile Leu 
            100                 105                 110         


Ile Gln Tyr Asp Arg Thr Leu Leu Val Ala Asp Pro Arg Arg Cys Glu 
        115                 120                 125             


Ser Lys Lys Phe Gly Gly Pro Gly Ala Arg Ala Arg Tyr Gln Lys Ser 
    130                 135                 140                 


Tyr Arg 
145     


<210>  89
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Pro Gly Val Thr Val Lys Asp Val Asn Gln Gln Glu Phe Val Arg 
1               5                   10                  15      


Ala Leu Ala Ala Phe Leu Lys Lys Ser Gly Lys Leu Lys Val Pro Glu 
            20                  25                  30          


Trp Val Asp Thr Val Lys Leu Ala Lys His Lys Glu Leu Ala Pro Tyr 
        35                  40                  45              


Asp Glu Asn Trp Phe Tyr Thr Arg Ala Ala Ser Thr Ala Arg His Leu 
    50                  55                  60                  


Tyr Leu Arg Gly Gly Ala Gly Val Gly Ser Met Thr Lys Ile Tyr Gly 
65                  70                  75                  80  


Gly Arg Gln Arg Asn Gly Val Met Pro Ser His Phe Ser Arg Gly Ser 
                85                  90                  95      


Lys Ser Val Ala Arg Arg Val Leu Gln Ala Leu Glu Gly Leu Lys Met 
            100                 105                 110         


Val Glu Lys Asp Gln Asp Gly Gly Arg Lys Leu Thr Pro Gln Gly Gln 
        115                 120                 125             


Arg Asp Leu Asp Arg Ile Ala Gly Gln Val Ala Ala Ala Asn Lys Lys 
    130                 135                 140                 


His 
145 


<210>  90
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Ala Asp Asp Ala Gly Ala Ala Gly Gly Pro Gly Gly Pro Gly Gly 
1               5                   10                  15      


Pro Gly Met Gly Asn Arg Gly Gly Phe Arg Gly Gly Phe Gly Ser Gly 
            20                  25                  30          


Ile Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg 
        35                  40                  45              


Gly Ala Arg Gly Gly Lys Ala Glu Asp Lys Glu Trp Met Pro Val Thr 
    50                  55                  60                  


Lys Leu Gly Arg Leu Val Lys Asp Met Lys Ile Lys Ser Leu Glu Glu 
65                  70                  75                  80  


Ile Tyr Leu Phe Ser Leu Pro Ile Lys Glu Ser Glu Ile Ile Asp Phe 
                85                  90                  95      


Phe Leu Gly Ala Ser Leu Lys Asp Glu Val Leu Lys Ile Met Pro Val 
            100                 105                 110         


Gln Lys Gln Thr Arg Ala Gly Gln Arg Thr Arg Phe Lys Ala Phe Val 
        115                 120                 125             


Ala Ile Gly Asp Tyr Asn Gly His Val Gly Leu Gly Val Lys Cys Ser 
    130                 135                 140                 


Lys Glu Val Ala Thr Ala Ile Arg Gly Ala Ile Ile Leu Ala Lys Leu 
145                 150                 155                 160 


Ser Ile Val Pro Val Arg Arg Gly Tyr Trp Gly Asn Lys Ile Gly Lys 
                165                 170                 175     


Pro His Thr Val Pro Cys Lys Val Thr Gly Arg Cys Gly Ser Val Leu 
            180                 185                 190         


Val Arg Leu Ile Pro Ala Pro Arg Gly Thr Gly Ile Val Ser Ala Pro 
        195                 200                 205             


Val Pro Lys Lys Leu Leu Met Met Ala Gly Ile Asp Asp Cys Tyr Thr 
    210                 215                 220                 


Ser Ala Arg Gly Cys Thr Ala Thr Leu Gly Asn Phe Ala Lys Ala Thr 
225                 230                 235                 240 


Phe Asp Ala Ile Ser Lys Thr Tyr Ser Tyr Leu Thr Pro Asp Leu Trp 
                245                 250                 255     


Lys Glu Thr Val Phe Thr Lys Ser Pro Tyr Gln Glu Phe Thr Asp His 
            260                 265                 270         


Leu Val Lys Thr His Thr Arg Val Ser Val Gln Arg Thr Gln Ala Pro 
        275                 280                 285             


Ala Val Ala Thr Thr 
    290             


<210>  91
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Pro Arg Ser Phe Leu Val Lys Lys Ile Lys Gly Asp Gly Phe Gln 
1               5                   10                  15      


Cys Ser Gly Val Pro Ala Pro Thr Tyr His Pro Leu Glu Thr Ala Tyr 
            20                  25                  30          


Val Leu Pro Gly Ala Arg Gly Pro Pro Gly Asp Asn Gly Tyr Ala Pro 
        35                  40                  45              


His Arg Leu Pro Pro Ser Ser Tyr Asp Ala Asp Gln Lys Pro Gly Leu 
    50                  55                  60                  


Glu Leu Ala Pro Ala Glu Pro Ala Tyr Pro Pro Ala Ala Pro Glu Glu 
65                  70                  75                  80  


Tyr Ser Asp Pro Glu Ser Pro Gln Ser Ser Leu Ser Ala Arg Tyr Phe 
                85                  90                  95      


Arg Gly Glu Ala Ala Val Thr Asp Ser Tyr Ser Met Asp Ala Phe Phe 
            100                 105                 110         


Ile Ser Asp Gly Arg Ser Arg Arg Arg Arg Gly Gly Gly Gly Gly Asp 
        115                 120                 125             


Ala Gly Gly Ser Gly Asp Ala Gly Gly Ala Gly Gly Arg Ala Gly Arg 
    130                 135                 140                 


Ala Gly Ala Gln Ala Gly Gly Gly His Arg His Ala Cys Ala Glu Cys 
145                 150                 155                 160 


Gly Lys Thr Tyr Ala Thr Ser Ser Asn Leu Ser Arg His Lys Gln Thr 
                165                 170                 175     


His Arg Ser Leu Asp Ser Gln Leu Ala Arg Lys Cys Pro Thr Cys Gly 
            180                 185                 190         


Lys Ala Tyr Val Ser Met Pro Ala Leu Ala Met His Leu Leu Thr His 
        195                 200                 205             


Asn Leu Arg His Lys Cys Gly Val Cys Gly Lys Ala Phe Ser Arg Pro 
    210                 215                 220                 


Trp Leu Leu Gln Gly His Met Arg Ser His Thr Gly Glu Lys Pro Phe 
225                 230                 235                 240 


Gly Cys Ala His Cys Gly Lys Ala Phe Ala Asp Arg Ser Asn Leu Arg 
                245                 250                 255     


Ala His Met Gln Thr His Ser Ala Phe Lys His Tyr Arg Cys Arg Gln 
            260                 265                 270         


Cys Asp Lys Ser Phe Ala Leu Lys Ser Tyr Leu His Lys His Cys Glu 
        275                 280                 285             


Ala Ala Cys Ala Lys Ala Ala Glu Pro Pro Pro Pro Thr Pro Ala Gly 
    290                 295                 300                 


Pro Ala Ser 
305         


<210>  92
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Val Leu Leu Thr Met Ile Ala Arg Val Ala Asp Gly Leu Pro Leu 
1               5                   10                  15      


Ala Ala Ser Met Gln Glu Asp Glu Gln Ser Gly Arg Asp Leu Gln Gln 
            20                  25                  30          


Tyr Gln Ser Gln Ala Lys Gln Leu Phe Arg Lys Leu Asn Glu Gln Ser 
        35                  40                  45              


Pro Thr Arg Cys Thr Leu Glu Ala Gly Ala Met Thr Phe His Tyr Ile 
    50                  55                  60                  


Ile Glu Gln Gly Val Cys Tyr Leu Val Leu Cys Glu Ala Ala Phe Pro 
65                  70                  75                  80  


Lys Lys Leu Ala Phe Ala Tyr Leu Glu Asp Leu His Ser Glu Phe Asp 
                85                  90                  95      


Glu Gln His Gly Lys Lys Val Pro Thr Val Ser Arg Pro Tyr Ser Phe 
            100                 105                 110         


Ile Glu Phe Asp Thr Phe Ile Gln Lys Thr Lys Lys Leu Tyr Ile Asp 
        115                 120                 125             


Ser Arg Ala Arg Arg Asn Leu Gly Ser Ile Asn Thr Glu Leu Gln Asp 
    130                 135                 140                 


Val Gln Arg Ile Met Val Ala Asn Ile Glu Glu Val Leu Gln Arg Gly 
145                 150                 155                 160 


Glu Ala Leu Ser Ala Leu Asp Ser Lys Ala Asn Asn Leu Ser Ser Leu 
                165                 170                 175     


Ser Lys Lys Tyr Arg Gln Asp Ala Lys Tyr Leu Asn Met Arg Ser Thr 
            180                 185                 190         


Tyr Ala Lys Leu Ala Ala Val Ala Val Phe Phe Ile Met Leu Ile Val 
        195                 200                 205             


Tyr Val Arg Phe Trp Trp Leu 
    210                 215 


<210>  93
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Arg Leu Glu Trp Gly Pro Arg Pro Ala Ala Leu Pro Trp Pro Ala 
1               5                   10                  15      


Gly Met Cys Ala Ala Glu Arg Ala Glu Gly Ala Phe Thr Leu Gln Ser 
            20                  25                  30          


Val Ala Gln Pro Met Arg Pro Ile Ala Ser Thr Ala Thr Lys Cys Gly 
        35                  40                  45              


Asn Cys Gly Pro Gly Tyr Ser Thr Pro Leu Glu Ala Met Lys Gly Pro 
    50                  55                  60                  


Arg Glu Glu Ile Val Tyr Leu Pro Cys Ile Tyr Arg Asn Thr Gly Thr 
65                  70                  75                  80  


Glu Ala Pro Asp Tyr Leu Ala Thr Val Asp Val Asp Pro Lys Ser Pro 
                85                  90                  95      


Gln Tyr Cys Gln Val Ile His Arg Leu Pro Met Pro Asn Leu Lys Asp 
            100                 105                 110         


Glu Leu His His Ser Gly Trp Asn Thr Cys Ser Ser Cys Phe Gly Asp 
        115                 120                 125             


Ser Thr Lys Ser Arg Thr Lys Leu Val Leu Pro Ser Leu Ile Ser Ser 
    130                 135                 140                 


Arg Ile Tyr Val Val Asp Val Gly Ser Glu Pro Arg Ala Pro Lys Leu 
145                 150                 155                 160 


His Lys Val Ile Glu Pro Lys Asp Ile His Ala Lys Cys Glu Leu Ala 
                165                 170                 175     


Phe Leu His Thr Ser His Cys Leu Ala Ser Gly Glu Val Met Ile Ser 
            180                 185                 190         


Ser Leu Gly Asp Val Lys Gly Asn Gly Lys Gly Gly Phe Val Leu Leu 
        195                 200                 205             


Asp Gly Glu Thr Phe Glu Val Lys Gly Thr Trp Glu Arg Pro Gly Gly 
    210                 215                 220                 


Ala Ala Pro Leu Gly Tyr Asp Phe Trp Tyr Gln Pro Arg His Asn Val 
225                 230                 235                 240 


Met Ile Ser Thr Glu Trp Ala Ala Pro Asn Val Leu Arg Asp Gly Phe 
                245                 250                 255     


Asn Pro Ala Asp Val Glu Ala Gly Leu Tyr Gly Ser His Leu Tyr Val 
            260                 265                 270         


Trp Asp Trp Gln Arg His Glu Ile Val Gln Thr Leu Ser Leu Lys Asp 
        275                 280                 285             


Gly Leu Ile Pro Leu Glu Ile Arg Phe Leu His Asn Pro Asp Ala Ala 
    290                 295                 300                 


Gln Gly Phe Val Gly Cys Ala Leu Ser Ser Thr Ile Gln Arg Phe Tyr 
305                 310                 315                 320 


Lys Asn Glu Gly Gly Thr Trp Ser Val Glu Lys Val Ile Gln Val Pro 
                325                 330                 335     


Pro Lys Lys Val Lys Gly Trp Leu Leu Pro Glu Met Pro 
            340                 345                 


<210>  94
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ser Lys Gln Gln Pro Thr Gln Phe Ile Asn Pro Glu Thr Pro Gly 
1               5                   10                  15      


Tyr Val Gly Phe Ala Asn Leu Pro Asn Gln Val His Arg Lys Ser Val 
            20                  25                  30          


Lys Lys Gly Phe Glu Phe Thr Leu Met Val Val Gly Glu Ser Gly Leu 
        35                  40                  45              


Gly Lys Ser Thr Leu Ile Asn Ser Leu Phe Leu Thr Asp Leu Tyr Pro 
    50                  55                  60                  


Glu Arg Val Ile Pro Gly Ala Ala Glu Lys Ile Glu Arg Thr Val Gln 
65                  70                  75                  80  


Ile Glu Ala Ser Thr Val Glu Ile Glu Glu Arg Gly Val Lys Leu Arg 
                85                  90                  95      


Leu Thr Val Val Asp Thr Pro Gly Tyr Gly Asp Ala Ile Asn Cys Arg 
            100                 105                 110         


Asp Cys Phe Lys Thr Ile Ile Ser Tyr Ile Asp Glu Gln Phe Glu Arg 
        115                 120                 125             


Tyr Leu His Asp Glu Ser Gly Leu Asn Arg Arg His Ile Ile Asp Asn 
    130                 135                 140                 


Arg Val His Cys Cys Phe Tyr Phe Ile Ser Pro Phe Gly His Gly Leu 
145                 150                 155                 160 


Lys Pro Leu Asp Val Ala Phe Met Lys Ala Ile His Asn Lys Val Asn 
                165                 170                 175     


Ile Val Pro Val Ile Ala Lys Ala Asp Thr Leu Thr Leu Lys Glu Arg 
            180                 185                 190         


Glu Arg Leu Lys Lys Arg Ile Leu Asp Glu Ile Glu Glu His Asn Ile 
        195                 200                 205             


Lys Ile Tyr His Leu Pro Asp Ala Glu Ser Asp Glu Asp Glu Asp Phe 
    210                 215                 220                 


Lys Glu Gln Thr Arg Leu Leu Lys Ala Ser Ile Pro Phe Ser Val Val 
225                 230                 235                 240 


Gly Ser Asn Gln Leu Ile Glu Ala Lys Gly Lys Lys Val Arg Gly Arg 
                245                 250                 255     


Leu Tyr Pro Trp Gly Val Val Glu Val Glu Asn Pro Glu His Asn Asp 
            260                 265                 270         


Phe Leu Lys Leu Arg Thr Met Leu Ile Thr His Met Gln Asp Leu Gln 
        275                 280                 285             


Glu Val Thr Gln Asp Leu His Tyr Glu Asn Phe Arg Ser Glu Arg Leu 
    290                 295                 300                 


Lys Arg Gly Gly Arg Lys Val Glu Asn Glu Asp Met Asn Lys Asp Gln 
305                 310                 315                 320 


Ile Leu Leu Glu Lys Glu Ala Glu Leu Arg Arg Met Gln Glu Met Ile 
                325                 330                 335     


Ala Arg Met Gln Ala Gln Met Gln Met Gln Met Gln Gly Gly Asp Gly 
            340                 345                 350         


Asp Gly Gly Ala Leu Gly His His Val 
        355                 360     


<210>  95
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Val Ile Arg Val Tyr Ile Ala Ser Ser Ser Gly Ser Thr Ala Ile 
1               5                   10                  15      


Lys Lys Lys Gln Gln Asp Val Leu Gly Phe Leu Glu Ala Asn Lys Ile 
            20                  25                  30          


Gly Phe Glu Glu Lys Asp Ile Ala Ala Asn Glu Glu Asn Arg Lys Trp 
        35                  40                  45              


Met Arg Glu Asn Val Pro Glu Asn Ser Arg Pro Ala Thr Gly Tyr Pro 
    50                  55                  60                  


Leu Pro Pro Gln Ile Phe Asn Glu Ser Gln Tyr Arg Gly Asp Tyr Asp 
65                  70                  75                  80  


Ala Phe Phe Glu Ala Arg Glu Asn Asn Ala Val Tyr Ala Phe Leu Gly 
                85                  90                  95      


Leu Thr Ala Pro Pro Gly Ser Lys Glu Ala Glu Val Gln Ala Lys Gln 
            100                 105                 110         


Gln Ala 
        


<210>  96
<211>  6885
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ala Ser Ser Pro Glu Leu Pro Thr Glu Asp Glu Gln Gly Ser Trp 
1               5                   10                  15      


Gly Ile Asp Asp Leu His Ile Ser Leu Gln Ala Glu Gln Glu Asp Thr 
            20                  25                  30          


Gln Lys Lys Ala Phe Thr Cys Trp Ile Asn Ser Gln Leu Ala Arg His 
        35                  40                  45              


Thr Ser Pro Ser Val Ile Ser Asp Leu Phe Thr Asp Ile Lys Lys Gly 
    50                  55                  60                  


His Val Leu Leu Asp Leu Leu Glu Val Leu Ser Gly Gln Gln Leu Pro 
65                  70                  75                  80  


Arg Asp Lys Gly Ser Asn Thr Phe Gln Cys Arg Ile Asn Ile Glu His 
                85                  90                  95      


Ala Leu Thr Phe Leu Arg Asn Arg Ser Ile Lys Leu Ile Asn Ile His 
            100                 105                 110         


Val Thr Asp Ile Ile Asp Gly Asn Pro Ser Ile Ile Leu Gly Leu Ile 
        115                 120                 125             


Trp Thr Ile Ile Leu His Phe His Ile Glu Lys Leu Ala Gln Thr Leu 
    130                 135                 140                 


Ser Cys Asn Tyr Asn Gln Pro Ser Leu Asp Asp Val Ser Val Val Asp 
145                 150                 155                 160 


Ser Ser Pro Ala Ser Ser Pro Pro Ala Lys Lys Cys Ser Lys Val Gln 
                165                 170                 175     


Ala Arg Trp Gln Met Ser Ala Arg Lys Ala Leu Leu Leu Trp Ala Gln 
            180                 185                 190         


Glu Gln Cys Ala Thr Tyr Glu Ser Val Asn Val Thr Asp Phe Lys Ser 
        195                 200                 205             


Ser Trp Arg Asn Gly Met Ala Phe Leu Ala Ile Ile His Ala Leu Arg 
    210                 215                 220                 


Pro Asp Leu Ile Asp Met Lys Ser Val Lys His Arg Ser Asn Lys Asp 
225                 230                 235                 240 


Asn Leu Arg Glu Ala Phe Arg Ile Ala Glu Gln Glu Leu Lys Ile Pro 
                245                 250                 255     


Arg Leu Leu Glu Pro Glu Asp Val Asp Val Val Asp Pro Asp Glu Lys 
            260                 265                 270         


Ser Ile Met Thr Tyr Val Ala Gln Phe Leu Gln Tyr Ser Lys Asp Ala 
        275                 280                 285             


Pro Gly Thr Gly Glu Glu Ala Gln Gly Lys Val Lys Asp Ala Met Gly 
    290                 295                 300                 


Trp Leu Thr Leu Gln Lys Glu Lys Leu Gln Lys Leu Leu Lys Asp Ser 
305                 310                 315                 320 


Glu Asn Asp Thr Tyr Phe Lys Lys Tyr Asn Ser Leu Leu Ser Phe Met 
                325                 330                 335     


Glu Ser Phe Asn Glu Glu Lys Lys Ser Phe Leu Asp Val Leu Ser Ile 
            340                 345                 350         


Lys Arg Asp Leu Asp Glu Leu Asp Lys Asp His Leu Gln Leu Arg Glu 
        355                 360                 365             


Ala Trp Asp Gly Leu Asp His Gln Ile Asn Ala Trp Lys Ile Lys Leu 
    370                 375                 380                 


Asn Tyr Ala Leu Pro Pro Pro Leu His Gln Thr Glu Ala Trp Leu Gln 
385                 390                 395                 400 


Glu Val Glu Glu Leu Met Asp Glu Asp Leu Ser Ala Ser Gln Asp His 
                405                 410                 415     


Ser Gln Ala Val Thr Leu Ile Gln Glu Lys Met Thr Leu Phe Lys Ser 
            420                 425                 430         


Leu Met Asp Arg Phe Glu His His Ser Asn Ile Leu Leu Thr Phe Glu 
        435                 440                 445             


Asn Lys Asp Glu Asn His Leu Pro Leu Val Pro Pro Asn Lys Leu Glu 
    450                 455                 460                 


Glu Met Lys Arg Arg Ile Asn Asn Ile Leu Glu Lys Lys Phe Ile Leu 
465                 470                 475                 480 


Leu Leu Glu Phe His Tyr Tyr Lys Cys Leu Val Leu Gly Leu Val Asp 
                485                 490                 495     


Glu Val Lys Ser Lys Leu Asp Ile Trp Asn Ile Lys Tyr Gly Ser Arg 
            500                 505                 510         


Glu Ser Val Glu Leu Leu Leu Glu Asp Trp His Lys Phe Ile Glu Glu 
        515                 520                 525             


Lys Glu Phe Leu Ala Arg Leu Asp Thr Ser Phe Gln Lys Cys Gly Glu 
    530                 535                 540                 


Ile Tyr Lys Asn Leu Ala Gly Glu Cys Gln Asn Ile Asn Lys Gln Tyr 
545                 550                 555                 560 


Met Met Val Lys Ser Asp Val Cys Met Tyr Arg Lys Asn Ile Tyr Asn 
                565                 570                 575     


Val Lys Ser Thr Leu Gln Lys Val Leu Ala Cys Trp Ala Thr Tyr Val 
            580                 585                 590         


Glu Asn Leu Arg Leu Leu Arg Ala Cys Phe Glu Glu Thr Lys Lys Glu 
        595                 600                 605             


Glu Ile Lys Glu Val Pro Phe Glu Thr Leu Ala Gln Trp Asn Leu Glu 
    610                 615                 620                 


His Ala Thr Leu Asn Glu Ala Gly Asn Phe Leu Val Glu Val Ser Asn 
625                 630                 635                 640 


Asp Val Val Gly Ser Ser Ile Ser Lys Glu Leu Arg Arg Leu Asn Lys 
                645                 650                 655     


Arg Trp Arg Lys Leu Val Ser Lys Thr Gln Leu Glu Met Asn Leu Pro 
            660                 665                 670         


Leu Met Ile Lys Lys Gln Asp Gln Pro Thr Phe Asp Asn Ser Gly Asn 
        675                 680                 685             


Ile Leu Ser Lys Glu Glu Lys Ala Thr Val Glu Phe Ser Thr Asp Met 
    690                 695                 700                 


Ser Val Glu Leu Pro Glu Asn Tyr Asn Gln Asn Ile Lys Ala Gly Glu 
705                 710                 715                 720 


Lys His Glu Lys Glu Asn Glu Glu Phe Thr Gly Gln Leu Lys Val Ala 
                725                 730                 735     


Lys Asp Val Glu Lys Leu Ile Gly Gln Val Glu Ile Trp Glu Ala Glu 
            740                 745                 750         


Ala Lys Ser Val Leu Asp Gln Asp Asp Val Asp Thr Ser Met Glu Glu 
        755                 760                 765             


Ser Leu Lys His Leu Ile Ala Lys Gly Ser Met Phe Asp Glu Leu Met 
    770                 775                 780                 


Ala Arg Ser Glu Asp Met Leu Gln Met Asp Ile Gln Asn Ile Ser Ser 
785                 790                 795                 800 


Gln Glu Ser Phe Gln His Val Leu Thr Thr Gly Leu Gln Ala Lys Ile 
                805                 810                 815     


Gln Glu Ala Lys Glu Lys Val Gln Ile Asn Val Val Lys Leu Ile Ala 
            820                 825                 830         


Ala Leu Lys Asn Leu Thr Asp Val Ser Pro Asp Leu Asp Ile Arg Leu 
        835                 840                 845             


Lys Met Glu Glu Ser Gln Lys Glu Leu Glu Ser Tyr Met Met Arg Ala 
    850                 855                 860                 


Gln Gln Leu Leu Gly Gln Arg Glu Ser Pro Gly Glu Leu Ile Ser Lys 
865                 870                 875                 880 


His Lys Glu Ala Leu Ile Ile Ser Asn Thr Lys Ser Leu Ala Lys Tyr 
                885                 890                 895     


Leu Lys Ala Val Glu Glu Leu Lys Asn Asn Val Thr Glu Asp Ile Lys 
            900                 905                 910         


Met Ser Leu Glu Glu Lys Ser Arg Asp Val Cys Ala Lys Trp Glu Ser 
        915                 920                 925             


Leu His His Glu Leu Ser Leu Tyr Val Gln Gln Leu Lys Ile Asp Ile 
    930                 935                 940                 


Glu Lys Gly Lys Leu Ser Asp Asn Ile Leu Lys Leu Glu Lys Gln Ile 
945                 950                 955                 960 


Asn Lys Glu Lys Lys Leu Ile Arg Arg Gly Arg Thr Lys Gly Leu Ile 
                965                 970                 975     


Lys Glu His Glu Ala Cys Phe Ser Glu Glu Gly Cys Leu Tyr Gln Leu 
            980                 985                 990         


Asn His His Met Glu Val Leu Arg  Glu Leu Cys Glu Glu  Leu Pro Ser 
        995                 1000                 1005             


Gln Lys  Ser Gln Gln Glu Val  Lys Arg Leu Leu Lys  Asp Tyr Glu 
    1010                 1015                 1020             


Gln Lys  Ile Glu Arg Leu Leu  Lys Cys Ala Ser Glu  Ile His Met 
    1025                 1030                 1035             


Thr Leu  Gln Pro Thr Ala Gly  Gly Thr Ser Lys Asn  Glu Gly Thr 
    1040                 1045                 1050             


Ile Thr  Thr Ser Glu Asn Arg  Gly Gly Asp Pro His  Ser Glu Ala 
    1055                 1060                 1065             


Pro Phe  Ala Lys Ser Asp Asn  Gln Pro Ser Thr Glu  Lys Ala Met 
    1070                 1075                 1080             


Glu Pro  Thr Met Lys Phe Ser  Leu Ala Ser Val Leu  Arg Pro Leu 
    1085                 1090                 1095             


Gln Glu  Glu Ser Ile Met Glu  Lys Asp Tyr Ser Ala  Ser Ile Asn 
    1100                 1105                 1110             


Ser Leu  Leu Glu Arg Tyr Asp  Thr Tyr Arg Asp Ile  Leu Glu His 
    1115                 1120                 1125             


His Leu  Gln Asn Asn Lys Phe  Arg Ile Thr Ser Asp  Phe Ser Ser 
    1130                 1135                 1140             


Glu Glu  Asp Arg Ser Ser Ser  Cys Leu Gln Ala Lys  Leu Thr Asp 
    1145                 1150                 1155             


Leu Gln  Val Ile Lys Asn Glu  Thr Asp Ala Arg Trp  Lys Glu Phe 
    1160                 1165                 1170             


Glu Ile  Ile Ser Leu Lys Leu  Glu Asn His Val Asn  Asp Ile Lys 
    1175                 1180                 1185             


Lys Pro  Phe Val Ile Lys Glu  Arg Asp Thr Leu Lys  Glu Arg Glu 
    1190                 1195                 1200             


Arg Glu  Leu Gln Met Thr Leu  Asn Thr Arg Met Glu  Ser Leu Glu 
    1205                 1210                 1215             


Thr Ala  Leu Arg Leu Val Leu  Pro Val Glu Lys Ala  Ser Leu Leu 
    1220                 1225                 1230             


Leu Cys  Gly Ser Asp Leu Pro  Leu His Lys Met Ala  Ile Gln Gly 
    1235                 1240                 1245             


Phe His  Leu Ile Asp Ala Asp  Arg Ile Tyr Gln His  Leu Arg Asn 
    1250                 1255                 1260             


Ile Gln  Asp Ser Ile Ala Lys  Gln Ile Glu Ile Cys  Asn Arg Leu 
    1265                 1270                 1275             


Glu Glu  Pro Gly Asn Phe Val  Leu Lys Glu Leu His  Pro Phe Asp 
    1280                 1285                 1290             


Leu His  Ala Met Gln Asn Ile  Ile Leu Lys Tyr Lys  Thr Gln Phe 
    1295                 1300                 1305             


Glu Gly  Met Asn His Arg Val  Gln Arg Ser Glu Asp  Thr Leu Lys 
    1310                 1315                 1320             


Ala Leu  Glu Asp Phe Leu Ala  Ser Leu Arg Thr Ala  Lys Leu Ser 
    1325                 1330                 1335             


Ala Glu  Pro Val Thr Asp Leu  Ser Ala Ser Asp Thr  Gln Val Ala 
    1340                 1345                 1350             


Gln Glu  Asn Thr Leu Thr Val  Lys Asn Lys Glu Gly  Glu Ile His 
    1355                 1360                 1365             


Leu Met  Lys Asp Lys Ala Lys  His Leu Asp Lys Cys  Leu Lys Met 
    1370                 1375                 1380             


Leu Asp  Met Ser Phe Lys Asp  Ala Glu Arg Gly Asp  Asp Thr Ser 
    1385                 1390                 1395             


Cys Glu  Asn Leu Leu Asp Ala  Phe Ser Ile Lys Leu  Ser Glu Thr 
    1400                 1405                 1410             


His Gly  Tyr Gly Val Gln Glu  Glu Phe Thr Glu Glu  Asn Lys Leu 
    1415                 1420                 1425             


Leu Glu  Ala Cys Ile Phe Lys  Asn Asn Glu Leu Leu  Lys Asn Ile 
    1430                 1435                 1440             


Gln Asp  Val Gln Ser Gln Ile  Ser Lys Ile Gly Leu  Lys Asp Pro 
    1445                 1450                 1455             


Thr Val  Pro Ala Val Lys His  Arg Lys Lys Ser Leu  Ile Arg Leu 
    1460                 1465                 1470             


Asp Lys  Val Leu Asp Glu Tyr  Glu Glu Glu Lys Arg  His Leu Gln 
    1475                 1480                 1485             


Glu Met  Ala Asn Ser Leu Pro  His Phe Lys Asp Gly  Arg Glu Lys 
    1490                 1495                 1500             


Thr Val  Asn Gln Gln Cys Gln  Asn Thr Val Val Leu  Trp Glu Asn 
    1505                 1510                 1515             


Thr Lys  Ala Leu Val Thr Glu  Cys Leu Glu Gln Cys  Gly Arg Val 
    1520                 1525                 1530             


Leu Glu  Leu Leu Lys Gln Tyr  Gln Asn Phe Lys Ser  Ile Leu Thr 
    1535                 1540                 1545             


Thr Leu  Ile Gln Lys Glu Glu  Ser Val Ile Ser Leu  Gln Ala Ser 
    1550                 1555                 1560             


Tyr Met  Gly Lys Glu Asn Leu  Lys Lys Arg Ile Ala  Glu Ile Glu 
    1565                 1570                 1575             


Ile Val  Lys Glu Glu Phe Asn  Glu His Leu Glu Val  Val Asp Lys 
    1580                 1585                 1590             


Ile Asn  Gln Val Cys Lys Asn  Leu Gln Phe Tyr Leu  Asn Lys Met 
    1595                 1600                 1605             


Lys Thr  Phe Glu Glu Pro Pro  Phe Glu Lys Glu Ala  Asn Ile Ile 
    1610                 1615                 1620             


Val Asp  Arg Trp Leu Asp Ile  Asn Glu Lys Thr Glu  Asp Tyr Tyr 
    1625                 1630                 1635             


Glu Asn  Leu Gly Arg Ala Leu  Ala Leu Trp Asp Lys  Leu Phe Asn 
    1640                 1645                 1650             


Leu Lys  Asn Val Ile Asp Glu  Trp Thr Glu Lys Ala  Leu Gln Lys 
    1655                 1660                 1665             


Met Glu  Leu His Gln Leu Thr  Glu Glu Asp Arg Glu  Arg Leu Lys 
    1670                 1675                 1680             


Glu Glu  Leu Gln Val His Glu  Gln Lys Thr Ser Glu  Phe Ser Arg 
    1685                 1690                 1695             


Arg Val  Ala Glu Ile Gln Phe  Leu Leu Gln Ser Ser  Glu Ile Pro 
    1700                 1705                 1710             


Leu Glu  Leu Gln Val Met Glu  Ser Ser Ile Leu Asn  Lys Met Glu 
    1715                 1720                 1725             


His Val  Gln Lys Cys Leu Thr  Gly Glu Ser Asn Cys  His Ala Leu 
    1730                 1735                 1740             


Ser Gly  Ser Thr Ala Glu Leu  Arg Glu Asp Leu Asp  Gln Ala Lys 
    1745                 1750                 1755             


Thr Gln  Ile Gly Met Thr Glu  Ser Leu Leu Lys Ala  Leu Ser Pro 
    1760                 1765                 1770             


Ser Asp  Ser Leu Glu Ile Phe  Thr Lys Leu Glu Glu  Ile Gln Gln 
    1775                 1780                 1785             


Gln Ile  Leu Gln Gln Lys His  Ser Met Ile Leu Leu  Glu Asn Gln 
    1790                 1795                 1800             


Ile Gly  Cys Leu Thr Pro Glu  Leu Ser Glu Leu Lys  Lys Gln Tyr 
    1805                 1810                 1815             


Glu Ser  Val Ser Asp Leu Phe  Asn Thr Lys Lys Ser  Val Leu Gln 
    1820                 1825                 1830             


Asp His  Phe Ser Lys Leu Leu  Asn Asp Gln Cys Lys  Asn Phe Asn 
    1835                 1840                 1845             


Asp Trp  Phe Ser Asn Ile Lys  Val Asn Leu Lys Glu  Cys Phe Glu 
    1850                 1855                 1860             


Ser Ser  Glu Thr Lys Lys Ser  Val Glu Gln Lys Leu  Gln Lys Leu 
    1865                 1870                 1875             


Ser Asp  Phe Leu Thr Leu Glu  Gly Arg Asn Ser Lys  Ile Lys Gln 
    1880                 1885                 1890             


Val Asp  Ser Val Leu Lys His  Val Lys Lys His Leu  Pro Lys Ala 
    1895                 1900                 1905             


His Val  Lys Glu Leu Ile Ser  Trp Leu Val Gly Gln  Glu Phe Glu 
    1910                 1915                 1920             


Leu Glu  Lys Met Glu Ser Ile  Cys Gln Ala Arg Ala  Lys Glu Leu 
    1925                 1930                 1935             


Glu Asp  Ser Leu Gln Gln Leu  Leu Arg Leu Gln Asp  Asp His Arg 
    1940                 1945                 1950             


Asn Leu  Arg Lys Trp Leu Thr  Asn Gln Glu Glu Lys  Trp Lys Gly 
    1955                 1960                 1965             


Met Glu  Glu Pro Gly Glu Lys  Thr Glu Leu Phe Cys  Gln Ala Leu 
    1970                 1975                 1980             


Ala Arg  Lys Arg Glu Gln Phe  Glu Ser Val Ala Gln  Leu Asn Asn 
    1985                 1990                 1995             


Ser Leu  Lys Glu Tyr Gly Phe  Thr Glu Glu Glu Glu  Ile Ile Met 
    2000                 2005                 2010             


Glu Ala  Thr Cys Leu Met Asp  Arg Tyr Gln Thr Leu  Leu Arg Gln 
    2015                 2020                 2025             


Leu Ser  Glu Ile Glu Glu Glu  Asp Lys Leu Leu Pro  Thr Glu Asp 
    2030                 2035                 2040             


Gln Ser  Phe Asn Asp Leu Ala  His Asp Val Ile His  Trp Ile Lys 
    2045                 2050                 2055             


Glu Ile  Lys Glu Ser Leu Met  Val Leu Asn Ser Ser  Glu Gly Lys 
    2060                 2065                 2070             


Met Pro  Leu Glu Glu Arg Ile  Gln Lys Ile Lys Glu  Ile Ile Leu 
    2075                 2080                 2085             


Leu Lys  Pro Glu Gly Asp Ala  Arg Ile Glu Thr Ile  Met Lys Gln 
    2090                 2095                 2100             


Ala Glu  Ser Ser Glu Ala Pro  Leu Val Gln Lys Thr  Leu Thr Asp 
    2105                 2110                 2115             


Ile Ser  Asn Gln Trp Asp Asn  Thr Leu His Leu Ala  Ser Thr Tyr 
    2120                 2125                 2130             


Leu Ser  His Gln Glu Lys Leu  Leu Leu Glu Gly Glu  Lys Tyr Leu 
    2135                 2140                 2145             


Gln Ser  Lys Glu Asp Leu Arg  Leu Met Leu Ile Glu  Leu Lys Lys 
    2150                 2155                 2160             


Lys Gln  Glu Ala Gly Phe Ala  Leu Gln His Gly Leu  Gln Glu Lys 
    2165                 2170                 2175             


Lys Ala  Gln Leu Lys Ile Tyr  Lys Lys Phe Leu Lys  Lys Ala Gln 
    2180                 2185                 2190             


Asp Leu  Thr Ser Leu Leu Lys  Glu Leu Lys Ser Gln  Gly Asn Tyr 
    2195                 2200                 2205             


Leu Leu  Glu Cys Thr Lys Asn  Pro Ser Phe Ser Glu  Glu Pro Trp 
    2210                 2215                 2220             


Leu Glu  Ile Lys His Leu His  Glu Ser Leu Leu Gln  Gln Leu Gln 
    2225                 2230                 2235             


Asp Ser  Val Gln Asn Leu Asp  Gly His Val Arg Glu  His Asp Ser 
    2240                 2245                 2250             


Tyr Gln  Val Cys Val Thr Asp  Leu Asn Thr Thr Leu  Asp Asn Phe 
    2255                 2260                 2265             


Ser Lys  Glu Phe Val Ser Phe  Ser Asp Lys Pro Val  Asp Gln Ile 
    2270                 2275                 2280             


Ala Val  Glu Glu Lys Leu Gln  Lys Leu Gln Glu Leu  Glu Asn Arg 
    2285                 2290                 2295             


Leu Ser  Leu Gln Asp Gly Thr  Leu Lys Lys Ile Leu  Ala Leu Ala 
    2300                 2305                 2310             


Lys Ser  Val Lys Gln Asn Thr  Ser Ser Val Gly Gln  Lys Ile Ile 
    2315                 2320                 2325             


Lys Asp  Asp Ile Lys Ser Leu  Gln Cys Lys Gln Lys  Asp Leu Glu 
    2330                 2335                 2340             


Asn Arg  Leu Ala Ser Ala Lys  Gln Glu Met Glu Cys  Cys Leu Asn 
    2345                 2350                 2355             


Ser Ile  Leu Lys Ser Lys Arg  Ser Thr Glu Lys Lys  Gly Lys Phe 
    2360                 2365                 2370             


Thr Leu  Pro Gly Arg Glu Lys  Gln Ala Thr Ser Asp  Val Gln Glu 
    2375                 2380                 2385             


Ser Thr  Gln Glu Ser Ala Ala  Val Glu Lys Leu Glu  Glu Asp Trp 
    2390                 2395                 2400             


Glu Ile  Asn Lys Asp Ser Ala  Val Glu Met Ala Met  Ser Lys Gln 
    2405                 2410                 2415             


Leu Ser  Leu Asn Ala Gln Glu  Ser Met Lys Asn Thr  Glu Asp Glu 
    2420                 2425                 2430             


Arg Lys  Val Asn Glu Leu Gln  Asn Gln Pro Leu Glu  Leu Asp Thr 
    2435                 2440                 2445             


Met Leu  Arg Asn Glu Gln Leu  Glu Glu Ile Glu Lys  Leu Tyr Thr 
    2450                 2455                 2460             


Gln Leu  Glu Ala Lys Lys Ala  Ala Ile Lys Pro Leu  Glu Gln Thr 
    2465                 2470                 2475             


Glu Cys  Leu Asn Lys Thr Glu  Thr Gly Ala Leu Val  Leu His Asn 
    2480                 2485                 2490             


Ile Gly  Tyr Ser Ala Gln His  Leu Asp Asn Leu Leu  Gln Ala Leu 
    2495                 2500                 2505             


Ile Thr  Leu Lys Lys Asn Lys  Glu Ser Gln Tyr Cys  Val Leu Arg 
    2510                 2515                 2520             


Asp Phe  Gln Glu Tyr Leu Ala  Ala Val Glu Ser Ser  Met Lys Ala 
    2525                 2530                 2535             


Leu Leu  Thr Asp Lys Glu Ser  Leu Lys Val Gly Pro  Leu Asp Ser 
    2540                 2545                 2550             


Val Thr  Tyr Leu Asp Lys Ile  Lys Lys Phe Ile Ala  Ser Ile Glu 
    2555                 2560                 2565             


Lys Glu  Lys Asp Ser Leu Gly  Asn Leu Lys Ile Lys  Trp Glu Asn 
    2570                 2575                 2580             


Leu Ser  Asn His Val Thr Asp  Met Asp Lys Lys Leu  Leu Glu Ser 
    2585                 2590                 2595             


Gln Ile  Lys Gln Leu Glu His  Gly Trp Glu Gln Val  Glu Gln Gln 
    2600                 2605                 2610             


Ile Gln  Lys Lys Tyr Ser Gln  Gln Val Val Glu Tyr  Asp Glu Phe 
    2615                 2620                 2625             


Thr Thr  Leu Met Asn Lys Val  Gln Asp Thr Glu Ile  Ser Leu Gln 
    2630                 2635                 2640             


Gln Gln  Gln Gln His Leu Gln  Leu Arg Leu Lys Ser  Pro Glu Glu 
    2645                 2650                 2655             


Arg Ala  Gly Asn Gln Ser Met  Ile Ala Leu Thr Thr  Asp Leu Gln 
    2660                 2665                 2670             


Ala Thr  Lys His Gly Phe Ser  Val Leu Lys Gly Gln  Ala Glu Leu 
    2675                 2680                 2685             


Gln Met  Lys Arg Ile Trp Gly  Glu Lys Glu Lys Lys  Asn Leu Glu 
    2690                 2695                 2700             


Asp Gly  Ile Asn Asn Leu Lys  Lys Gln Trp Glu Thr  Leu Glu Pro 
    2705                 2710                 2715             


Leu His  Leu Glu Ala Glu Asn  Gln Ile Lys Lys Cys  Asp Ile Arg 
    2720                 2725                 2730             


Asn Lys  Met Lys Glu Thr Ile  Leu Trp Ala Lys Asn  Leu Leu Gly 
    2735                 2740                 2745             


Glu Leu  Asn Pro Ser Ile Pro  Leu Leu Pro Asp Asp  Ile Leu Ser 
    2750                 2755                 2760             


Gln Ile  Arg Lys Cys Lys Val  Thr His Asp Gly Ile  Leu Ala Arg 
    2765                 2770                 2775             


Gln Gln  Ser Val Glu Ser Leu  Ala Glu Glu Val Lys  Asp Lys Val 
    2780                 2785                 2790             


Pro Ser  Leu Thr Thr Tyr Glu  Gly Ser Asp Leu Asn  Asn Thr Leu 
    2795                 2800                 2805             


Glu Asp  Leu Arg Asn Gln Tyr  Gln Met Leu Val Leu  Lys Ser Thr 
    2810                 2815                 2820             


Gln Arg  Ser Gln Gln Leu Glu  Phe Lys Leu Glu Glu  Arg Ser Asn 
    2825                 2830                 2835             


Phe Phe  Ala Ile Ile Arg Lys  Phe Gln Leu Met Val  Gln Glu Ser 
    2840                 2845                 2850             


Glu Thr  Leu Ile Ile Pro Arg  Val Glu Thr Ala Ala  Thr Glu Ala 
    2855                 2860                 2865             


Glu Leu  Lys His His His Val  Thr Leu Glu Ala Ser  Gln Lys Glu 
    2870                 2875                 2880             


Leu Gln  Glu Ile Asp Ser Gly  Ile Ser Thr His Leu  Gln Glu Leu 
    2885                 2890                 2895             


Thr Asn  Ile Tyr Glu Glu Leu  Asn Val Phe Glu Arg  Leu Phe Leu 
    2900                 2905                 2910             


Glu Asp  Gln Leu Lys Asn Leu  Lys Ile Arg Thr Asn  Arg Ile Gln 
    2915                 2920                 2925             


Arg Phe  Ile Gln Asn Thr Cys  Asn Glu Val Glu His  Lys Ile Lys 
    2930                 2935                 2940             


Phe Cys  Arg Gln Phe His Glu  Lys Thr Ser Ala Leu  Gln Glu Glu 
    2945                 2950                 2955             


Ala Asp  Ser Ile Gln Arg Asn  Glu Leu Leu Leu Asn  Gln Glu Val 
    2960                 2965                 2970             


Asn Lys  Gly Val Lys Glu Glu  Ile Tyr Asn Leu Lys  Asp Arg Leu 
    2975                 2980                 2985             


Thr Ala  Ile Lys Cys Cys Ile  Leu Gln Val Leu Lys  Leu Lys Lys 
    2990                 2995                 3000             


Val Phe  Asp Tyr Ile Gly Leu  Asn Trp Asp Phe Ser  Gln Leu Asp 
    3005                 3010                 3015             


Gln Leu  Gln Thr Gln Val Phe  Glu Lys Glu Lys Glu  Leu Glu Glu 
    3020                 3025                 3030             


Lys Ile  Lys Gln Leu Asp Thr  Phe Glu Glu Glu His  Gly Lys Tyr 
    3035                 3040                 3045             


Gln Ala  Leu Leu Ser Lys Met  Arg Ala Ile Asp Leu  Gln Ile Lys 
    3050                 3055                 3060             


Lys Met  Thr Glu Val Val Leu  Lys Ala Pro Asp Ser  Ser Pro Glu 
    3065                 3070                 3075             


Ser Arg  Arg Leu Asn Ala Gln  Ile Leu Ser Gln Arg  Ile Glu Lys 
    3080                 3085                 3090             


Ala Lys  Cys Leu Cys Asp Glu  Ile Ile Lys Lys Leu  Asn Glu Asn 
    3095                 3100                 3105             


Lys Thr  Phe Asp Asp Ser Phe  Lys Glu Lys Glu Ile  Leu Gln Ile 
    3110                 3115                 3120             


Lys Leu  Asn Ala Glu Glu Asn  Asp Lys Leu Tyr Lys  Val Leu Gln 
    3125                 3130                 3135             


Asn Met  Val Leu Glu Leu Ser  Pro Lys Glu Leu Asp  Glu Lys Asn 
    3140                 3145                 3150             


Cys Gln  Asp Lys Leu Glu Thr  Ser Leu His Val Leu  Asn Gln Ile 
    3155                 3160                 3165             


Lys Ser  Gln Leu Gln Gln Pro  Leu Leu Ile Asn Leu  Glu Ile Lys 
    3170                 3175                 3180             


His Ile  Gln Asn Glu Lys Asp  Asn Cys Glu Ala Phe  Gln Glu Gln 
    3185                 3190                 3195             


Val Trp  Ala Glu Met Cys Ser  Ile Lys Ala Val Thr  Ala Ile Glu 
    3200                 3205                 3210             


Lys Gln  Arg Glu Glu Asn Ser  Ser Glu Ala Ser Asp  Val Glu Thr 
    3215                 3220                 3225             


Lys Leu  Arg Glu Phe Glu Asp  Leu Gln Met Gln Leu  Asn Thr Ser 
    3230                 3235                 3240             


Ile Asp  Leu Arg Thr Asn Val  Leu Asn Asp Ala Tyr  Glu Asn Leu 
    3245                 3250                 3255             


Thr Arg  Tyr Lys Glu Ala Val  Thr Arg Ala Val Glu  Ser Ile Thr 
    3260                 3265                 3270             


Ser Leu  Glu Ala Ile Ile Ile  Pro Tyr Arg Val Asp  Val Gly Asn 
    3275                 3280                 3285             


Pro Glu  Glu Ser Leu Glu Met  Pro Leu Arg Lys Gln  Glu Glu Leu 
    3290                 3295                 3300             


Glu Ser  Thr Val Ala His Ile  Gln Asp Leu Thr Glu  Lys Leu Gly 
    3305                 3310                 3315             


Met Ile  Ser Ser Pro Glu Ala  Lys Leu Gln Leu Gln  Tyr Thr Leu 
    3320                 3325                 3330             


Gln Glu  Leu Val Ser Lys Asn  Ser Ala Met Lys Glu  Ala Phe Lys 
    3335                 3340                 3345             


Ala Gln  Glu Thr Glu Ala Glu  Arg Tyr Leu Glu Asn  Tyr Lys Cys 
    3350                 3355                 3360             


Tyr Arg  Lys Met Glu Glu Asp  Ile Tyr Thr Asn Leu  Ser Lys Met 
    3365                 3370                 3375             


Glu Thr  Val Leu Gly Gln Ser  Met Ser Ser Leu Pro  Leu Ser Tyr 
    3380                 3385                 3390             


Arg Glu  Ala Leu Glu Arg Leu  Glu Gln Ser Lys Ala  Leu Val Ser 
    3395                 3400                 3405             


Asn Leu  Ile Ser Thr Lys Glu  Glu Leu Met Lys Leu  Arg Gln Ile 
    3410                 3415                 3420             


Leu Arg  Leu Leu Arg Leu Arg  Cys Thr Glu Asn Asp  Gly Ile Cys 
    3425                 3430                 3435             


Leu Leu  Lys Ile Val Ser Ala  Leu Trp Glu Lys Trp  Leu Ser Leu 
    3440                 3445                 3450             


Leu Glu  Ala Ala Lys Glu Trp  Glu Met Trp Cys Glu  Glu Leu Lys 
    3455                 3460                 3465             


Gln Glu  Trp Lys Phe Val Ser  Glu Glu Ile Glu Arg  Glu Ala Ile 
    3470                 3475                 3480             


Ile Leu  Asp Asn Leu Gln Glu  Glu Leu Pro Glu Ile  Ser Lys Thr 
    3485                 3490                 3495             


Lys Glu  Ala Ala Thr Thr Glu  Glu Leu Ser Glu Leu  Leu Asp Cys 
    3500                 3505                 3510             


Leu Cys  Gln Tyr Gly Glu Asn  Val Glu Lys Gln Gln  Leu Leu Leu 
    3515                 3520                 3525             


Thr Leu  Leu Leu Gln Arg Ile  Arg Ser Ile Gln Asn  Val Pro Glu 
    3530                 3535                 3540             


Ser Ser  Gly Ala Val Glu Thr  Val Pro Ala Phe Gln  Glu Ile Thr 
    3545                 3550                 3555             


Ser Met  Lys Glu Arg Cys Asn  Lys Leu Leu Gln Lys  Val Gln Lys 
    3560                 3565                 3570             


Asn Lys  Glu Leu Val Gln Thr  Glu Ile Gln Glu Arg  His Ser Phe 
    3575                 3580                 3585             


Thr Lys  Glu Ile Ile Ala Leu  Lys Asn Phe Phe Gln  Gln Thr Thr 
    3590                 3595                 3600             


Thr Ser  Phe Gln Asn Met Ala  Phe Gln Asp His Pro  Glu Lys Ser 
    3605                 3610                 3615             


Glu Gln  Phe Glu Glu Leu Gln  Ser Ile Leu Lys Lys  Gly Lys Leu 
    3620                 3625                 3630             


Thr Phe  Glu Asn Ile Met Glu  Lys Leu Arg Ile Lys  Tyr Ser Glu 
    3635                 3640                 3645             


Met Tyr  Thr Ile Val Pro Ala  Glu Ile Glu Ser Gln  Val Glu Glu 
    3650                 3655                 3660             


Cys Arg  Lys Ala Leu Glu Asp  Ile Asp Glu Lys Ile  Ser Asn Glu 
    3665                 3670                 3675             


Val Leu  Lys Ser Ser Pro Ser  Tyr Ala Met Arg Arg  Lys Ile Glu 
    3680                 3685                 3690             


Glu Ile  Asn Asn Gly Leu His  Asn Val Glu Lys Met  Leu Gln Gln 
    3695                 3700                 3705             


Lys Ser  Lys Asn Ile Glu Lys  Ala Gln Glu Ile Gln  Lys Lys Met 
    3710                 3715                 3720             


Trp Asp  Glu Leu Asp Leu Trp  His Ser Lys Leu Asn  Glu Leu Asp 
    3725                 3730                 3735             


Ser Glu  Val Gln Asp Ile Val  Glu Gln Asp Pro Gly  Gln Ala Gln 
    3740                 3745                 3750             


Glu Trp  Met Asp Asn Leu Met  Ile Pro Phe Gln Gln  Tyr Gln Gln 
    3755                 3760                 3765             


Val Ser  Gln Arg Ala Glu Cys  Arg Thr Ser Gln Leu  Asn Lys Ala 
    3770                 3775                 3780             


Thr Val  Lys Met Glu Glu Tyr  Ser Asp Leu Leu Lys  Ser Thr Glu 
    3785                 3790                 3795             


Ala Trp  Ile Glu Asn Thr Ser  His Leu Leu Ala Asn  Pro Ala Asp 
    3800                 3805                 3810             


Tyr Asp  Ser Leu Arg Thr Leu  Ser His His Ala Ser  Thr Val Gln 
    3815                 3820                 3825             


Met Ala  Leu Glu Asp Ser Glu  Gln Lys His Asn Leu  Leu His Ser 
    3830                 3835                 3840             


Ile Phe  Met Asp Leu Glu Asp  Leu Ser Ile Ile Phe  Glu Thr Asp 
    3845                 3850                 3855             


Glu Leu  Thr Gln Ser Ile Gln  Glu Leu Ser Asn Gln  Val Thr Ala 
    3860                 3865                 3870             


Leu Gln  Gln Lys Ile Met Glu  Ser Leu Pro Gln Ile  Gln Arg Met 
    3875                 3880                 3885             


Ala Asp  Asp Val Val Ala Ile  Glu Ser Glu Val Lys  Ser Met Glu 
    3890                 3895                 3900             


Lys Arg  Val Ser Lys Ile Lys  Thr Ile Leu Leu Ser  Lys Glu Ile 
    3905                 3910                 3915             


Phe Asp  Phe Ser Pro Glu Glu  His Leu Lys His Gly  Glu Val Ile 
    3920                 3925                 3930             


Leu Glu  Asn Ile Arg Pro Met  Lys Lys Thr Ile Ala  Glu Ile Val 
    3935                 3940                 3945             


Ser Tyr  Gln Val Glu Leu Arg  Leu Pro Gln Thr Gly  Met Lys Pro 
    3950                 3955                 3960             


Leu Pro  Val Phe Gln Arg Thr  Asn Gln Leu Leu Gln  Asp Ile Lys 
    3965                 3970                 3975             


Leu Leu  Glu Asn Val Thr Gln  Glu Gln Asn Glu Leu  Leu Lys Val 
    3980                 3985                 3990             


Val Ile  Lys Gln Thr Asn Glu  Trp Asp Glu Glu Ile  Glu Asn Leu 
    3995                 4000                 4005             


Lys Gln  Ile Leu Asn Asn Tyr  Ser Ala Gln Phe Ser  Leu Glu His 
    4010                 4015                 4020             


Met Ser  Pro Asp Gln Ala Asp  Lys Leu Pro Gln Leu  Gln Gly Glu 
    4025                 4030                 4035             


Ile Glu  Arg Met Glu Lys Gln  Ile Leu Ser Leu Asn  Gln Arg Lys 
    4040                 4045                 4050             


Glu Asp  Leu Leu Val Asp Leu  Lys Ala Thr Val Leu  Asn Leu His 
    4055                 4060                 4065             


Gln His  Leu Lys Gln Glu Gln  Glu Gly Val Glu Arg  Asp Arg Leu 
    4070                 4075                 4080             


Pro Ala  Val Thr Ser Glu Glu  Gly Gly Val Ala Glu  Arg Asp Ala 
    4085                 4090                 4095             


Ser Glu  Arg Lys Leu Asn Arg  Arg Gly Ser Met Ser  Tyr Leu Ala 
    4100                 4105                 4110             


Ala Val  Glu Glu Glu Val Glu  Glu Ser Ser Val Lys  Ser Asp Asn 
    4115                 4120                 4125             


Gly Asp  Glu Lys Ala Glu Pro  Ser Pro Gln Ser Trp  Ser Ser Leu 
    4130                 4135                 4140             


Trp Lys  His Asp Lys Asp Met  Glu Glu Asp Arg Ala  Ser Ser Ser 
    4145                 4150                 4155             


Ser Gly  Thr Ile Val Gln Glu  Ala Tyr Gly Lys Ile  Ser Thr Ser 
    4160                 4165                 4170             


Asp Asn  Ser Met Ala Gln Ile  Leu Thr Pro Asp Ser  Leu Asn Thr 
    4175                 4180                 4185             


Glu Gln  Gly Pro Glu Cys Ser  Leu Arg Pro Asn Gln  Thr Glu Glu 
    4190                 4195                 4200             


Gly Thr  Thr Pro Pro Ile Glu  Ala Asp Thr Leu Asp  Ser Ser Asp 
    4205                 4210                 4215             


Ala Gln  Gly Gly Leu Glu Pro  Arg Val Glu Lys Thr  Arg Pro Glu 
    4220                 4225                 4230             


Pro Thr  Glu Val Leu His Ala  Cys Lys Thr Gln Val  Ala Glu Leu 
    4235                 4240                 4245             


Glu Leu  Trp Leu Gln Gln Ala  Asn Val Ala Val Glu  Pro Glu Thr 
    4250                 4255                 4260             


Leu Asn  Ala Asp Met Gln Gln  Val Leu Glu Gln Gln  Leu Val Gly 
    4265                 4270                 4275             


Cys Gln  Ala Met Leu Thr Glu  Ile Glu His Lys Val  Ala Phe Leu 
    4280                 4285                 4290             


Leu Glu  Thr Cys Lys Asp Gln  Gly Leu Gly Asp Asn  Gly Ala Thr 
    4295                 4300                 4305             


Gln His  Glu Ala Glu Ala Leu  Ser Leu Lys Leu Lys  Thr Val Lys 
    4310                 4315                 4320             


Cys Asn  Leu Glu Lys Val Gln  Met Met Leu Gln Glu  Lys His Ser 
    4325                 4330                 4335             


Glu Asp  Gln His Pro Thr Ile  Leu Lys Lys Ser Ser  Glu Pro Glu 
    4340                 4345                 4350             


His Gln  Glu Ala Leu Gln Pro  Val Asn Leu Ser Glu  Leu Glu Ser 
    4355                 4360                 4365             


Ile Val  Thr Glu Arg Pro Gln  Phe Ser Arg Gln Lys  Asp Phe Gln 
    4370                 4375                 4380             


Gln Gln  Gln Val Leu Glu Leu  Lys Pro Met Glu Gln  Lys Asp Phe 
    4385                 4390                 4395             


Ile Lys  Phe Ile Glu Phe Asn  Ala Lys Lys Met Trp  Pro Gln Tyr 
    4400                 4405                 4410             


Cys Gln  His Asp Asn Asp Thr  Thr Gln Glu Ser Ser  Ala Ser Asn 
    4415                 4420                 4425             


Gln Ala  Ser Ser Pro Glu Asn  Asp Val Pro Asp Ser  Ile Leu Ser 
    4430                 4435                 4440             


Pro Gln  Gly Gln Asn Gly Asp  Lys Trp Gln Tyr Leu  His His Glu 
    4445                 4450                 4455             


Leu Ser  Ser Lys Ile Lys Leu  Pro Leu Pro Gln Leu  Val Glu Pro 
    4460                 4465                 4470             


Gln Val  Ser Thr Asn Met Gly  Ile Leu Pro Ser Val  Thr Met Tyr 
    4475                 4480                 4485             


Asn Phe  Arg Tyr Pro Thr Thr  Glu Glu Leu Lys Thr  Tyr Thr Thr 
    4490                 4495                 4500             


Gln Leu  Glu Asp Leu Arg Gln  Glu Ala Ser Asn Leu  Gln Thr Gln 
    4505                 4510                 4515             


Glu Asn  Met Thr Glu Glu Ala  Tyr Ile Asn Leu Asp  Lys Lys Leu 
    4520                 4525                 4530             


Phe Glu  Leu Phe Leu Thr Leu  Ser Gln Cys Leu Ser  Ser Val Glu 
    4535                 4540                 4545             


Glu Met  Leu Glu Met Pro Arg  Leu Tyr Arg Glu Asp  Gly Ser Gly 
    4550                 4555                 4560             


Gln Gln  Val His Tyr Glu Thr  Leu Ala Leu Glu Leu  Lys Lys Leu 
    4565                 4570                 4575             


Tyr Leu  Ala Leu Ser Asp Lys  Lys Gly Asp Leu Leu  Lys Ala Met 
    4580                 4585                 4590             


Thr Trp  Pro Gly Glu Asn Thr  Asn Leu Leu Leu Glu  Cys Phe Asp 
    4595                 4600                 4605             


Asn Leu  Gln Val Cys Leu Glu  His Thr Gln Ala Ala  Ala Val Cys 
    4610                 4615                 4620             


Arg Ser  Lys Ser Leu Lys Ala  Gly Leu Asp Tyr Asn  Arg Ser Tyr 
    4625                 4630                 4635             


Gln Asn  Glu Ile Lys Arg Leu  Tyr His Gln Leu Ile  Lys Ser Lys 
    4640                 4645                 4650             


Thr Ser  Leu Gln Gln Ser Leu  Asn Glu Ile Ser Gly  Gln Ser Val 
    4655                 4660                 4665             


Ala Glu  Gln Leu Gln Lys Ala  Asp Ala Tyr Thr Val  Glu Leu Glu 
    4670                 4675                 4680             


Asn Ala  Glu Ser Arg Val Ala  Lys Leu Arg Asp Glu  Gly Glu Arg 
    4685                 4690                 4695             


Leu His  Leu Pro Tyr Ala Leu  Leu Gln Glu Val Tyr  Lys Leu Glu 
    4700                 4705                 4710             


Asp Val  Leu Asp Ser Met Trp  Gly Met Leu Arg Ala  Arg Tyr Thr 
    4715                 4720                 4725             


Glu Leu  Ser Ser Pro Phe Val  Thr Glu Ser Gln Gln  Asp Ala Leu 
    4730                 4735                 4740             


Leu Gln  Gly Met Val Glu Leu  Val Lys Ile Gly Lys  Glu Lys Leu 
    4745                 4750                 4755             


Ala His  Gly His Leu Lys Gln  Thr Lys Ser Lys Val  Ala Leu Gln 
    4760                 4765                 4770             


Ala Gln  Ile Glu Asn His Lys  Val Phe Phe Gln Lys  Leu Val Ala 
    4775                 4780                 4785             


Asp Met  Leu Leu Ile Gln Ala  Tyr Ser Ala Lys Ile  Leu Pro Ser 
    4790                 4795                 4800             


Leu Leu  Gln Asn Arg Glu Thr  Phe Trp Ala Glu Gln  Val Thr Glu 
    4805                 4810                 4815             


Val Lys  Ile Leu Glu Glu Lys  Ser Arg Gln Cys Gly  Met Lys Leu 
    4820                 4825                 4830             


Gln Ser  Leu Leu Gln Lys Trp  Glu Glu Phe Asp Glu  Asn Tyr Ala 
    4835                 4840                 4845             


Ser Leu  Glu Lys Asp Leu Glu  Ile Leu Ile Ser Thr  Leu Pro Ser 
    4850                 4855                 4860             


Val Ser  Leu Val Glu Glu Thr  Glu Glu Arg Leu Val  Glu Arg Ile 
    4865                 4870                 4875             


Ser Phe  Tyr Gln Gln Ile Lys  Arg Asn Ile Gly Gly  Lys His Ala 
    4880                 4885                 4890             


Arg Leu  Tyr Gln Thr Leu Asn  Glu Gly Lys Gln Leu  Val Ala Ser 
    4895                 4900                 4905             


Val Ser  Cys Pro Glu Leu Glu  Gly Gln Ile Ala Lys  Leu Glu Glu 
    4910                 4915                 4920             


Gln Trp  Leu Ser Leu Asn Lys  Lys Ile Asp His Glu  Leu His Arg 
    4925                 4930                 4935             


Leu Gln  Ala Leu Leu Lys His  Leu Leu Ser Tyr Asn  Arg Asp Ser 
    4940                 4945                 4950             


Asp Gln  Leu Thr Lys Trp Leu  Glu Ser Ser Gln His  Thr Leu Asn 
    4955                 4960                 4965             


Tyr Trp  Lys Glu Gln Ser Leu  Asn Val Ser Gln Asp  Leu Asp Thr 
    4970                 4975                 4980             


Ile Arg  Ser Asn Ile Asn Asn  Phe Phe Glu Phe Ser  Lys Glu Val 
    4985                 4990                 4995             


Asp Glu  Lys Ser Ser Leu Lys  Thr Ala Val Ile Ser  Ile Gly Asn 
    5000                 5005                 5010             


Gln Leu  Leu His Leu Lys Glu  Thr Asp Thr Ala Thr  Leu Arg Ala 
    5015                 5020                 5025             


Ser Leu  Ala Gln Phe Glu Gln  Lys Trp Thr Met Leu  Ile Thr Gln 
    5030                 5035                 5040             


Leu Pro  Asp Ile Gln Glu Lys  Leu His Gln Leu Gln  Met Glu Lys 
    5045                 5050                 5055             


Leu Pro  Ser Arg Lys Ala Ile  Thr Glu Met Ile Ser  Trp Met Asn 
    5060                 5065                 5070             


Asn Val  Glu His Gln Thr Ser  Asp Glu Asp Ser Val  His Ser Pro 
    5075                 5080                 5085             


Ser Ser  Ala Ser Gln Val Lys  His Leu Leu Gln Lys  His Lys Glu 
    5090                 5095                 5100             


Phe Arg  Met Glu Met Asp Tyr  Lys Gln Trp Ile Val  Asp Phe Val 
    5105                 5110                 5115             


Asn Gln  Ser Leu Leu Gln Leu  Ser Thr Cys Asp Val  Glu Ser Lys 
    5120                 5125                 5130             


Arg Tyr  Glu Arg Thr Glu Phe  Ala Glu His Leu Gly  Glu Met Asn 
    5135                 5140                 5145             


Arg Gln  Trp His Arg Val His  Gly Met Leu Asn Arg  Lys Ile Gln 
    5150                 5155                 5160             


His Leu  Glu Gln Leu Leu Glu  Ser Ile Thr Glu Ser  Glu Asn Lys 
    5165                 5170                 5175             


Ile Gln  Ile Leu Asn Asn Trp  Leu Glu Ala Gln Glu  Glu Arg Leu 
    5180                 5185                 5190             


Lys Thr  Leu Gln Lys Pro Glu  Ser Val Ile Ser Val  Gln Lys Leu 
    5195                 5200                 5205             


Leu Leu  Asp Cys Gln Asp Ile  Glu Asn Gln Leu Ala  Ile Lys Ser 
    5210                 5215                 5220             


Lys Ala  Leu Asp Glu Leu Lys  Gln Ser Tyr Leu Thr  Leu Glu Ser 
    5225                 5230                 5235             


Gly Ala  Val Pro Leu Leu Glu  Asp Thr Ala Ser Arg  Ile Asp Glu 
    5240                 5245                 5250             


Leu Phe  Gln Lys Arg Ser Ser  Val Leu Thr Gln Val  Asn Gln Leu 
    5255                 5260                 5265             


Lys Thr  Ser Met Gln Ser Val  Leu Gln Glu Trp Lys  Ile Tyr Asp 
    5270                 5275                 5280             


Gln Leu  Tyr Asp Glu Val Asn  Met Met Thr Ile Arg  Phe Trp Tyr 
    5285                 5290                 5295             


Cys Met  Glu His Ser Lys Pro  Val Val Leu Ser Leu  Glu Thr Leu 
    5300                 5305                 5310             


Arg Cys  Gln Val Glu Asn Leu  Gln Ser Leu Gln Asp  Glu Ala Glu 
    5315                 5320                 5325             


Ser Ser  Glu Gly Ser Trp Glu  Lys Leu Gln Glu Val  Ile Gly Lys 
    5330                 5335                 5340             


Leu Lys  Gly Leu Cys Pro Ser  Val Ala Glu Ile Ile  Glu Glu Lys 
    5345                 5350                 5355             


Cys Gln  Asn Thr His Lys Arg  Trp Thr Gln Val Asn  Gln Ala Ile 
    5360                 5365                 5370             


Ala Asp  Gln Leu Gln Lys Ala  Gln Ser Leu Leu Gln  Leu Trp Lys 
    5375                 5380                 5385             


Ala Tyr  Ser Asn Ala His Gly  Glu Ala Ala Ala Arg  Leu Lys Gln 
    5390                 5395                 5400             


Gln Glu  Ala Lys Phe Gln Gln  Leu Ala Asn Ile Ser  Met Ser Gly 
    5405                 5410                 5415             


Asn Asn  Leu Ala Glu Ile Leu  Pro Pro Ala Leu Gln  Asp Ile Lys 
    5420                 5425                 5430             


Glu Leu  Gln His Asp Val Gln  Lys Thr Lys Glu Ala  Phe Leu Gln 
    5435                 5440                 5445             


Asn Ser  Ser Val Leu Asp Arg  Leu Pro Gln Pro Ala  Glu Ser Ser 
    5450                 5455                 5460             


Thr His  Met Leu Leu Pro Gly  Pro Leu His Ser Leu  Gln Arg Ala 
    5465                 5470                 5475             


Ala Tyr  Leu Glu Lys Met Leu  Leu Val Lys Ala Asn  Glu Phe Glu 
    5480                 5485                 5490             


Phe Val  Leu Ser Gln Phe Lys  Asp Phe Gly Val Arg  Leu Glu Ser 
    5495                 5500                 5505             


Leu Lys  Gly Leu Ile Met His  Glu Glu Glu Asn Leu  Asp Arg Leu 
    5510                 5515                 5520             


His Gln  Gln Glu Lys Glu Asn  Pro Asp Ser Phe Leu  Asn His Val 
    5525                 5530                 5535             


Leu Ala  Leu Thr Ala Gln Ser  Pro Asp Ile Glu His  Leu Asn Glu 
    5540                 5545                 5550             


Val Ser  Leu Lys Leu Pro Leu  Ser Asp Val Ala Val  Lys Thr Leu 
    5555                 5560                 5565             


Gln Asn  Met Asn Arg Gln Trp  Ile Arg Ala Thr Ala  Thr Ala Leu 
    5570                 5575                 5580             


Glu Arg  Cys Ser Glu Leu Gln  Gly Ile Gly Leu Asn  Glu Lys Phe 
    5585                 5590                 5595             


Leu Tyr  Cys Cys Glu Lys Trp  Ile Gln Leu Leu Glu  Lys Ile Glu 
    5600                 5605                 5610             


Glu Ala  Leu Lys Val Asp Val  Ala Asn Ser Leu Pro  Glu Leu Leu 
    5615                 5620                 5625             


Glu Gln  Gln Lys Thr Tyr Lys  Met Leu Glu Ala Glu  Val Ser Ile 
    5630                 5635                 5640             


Asn Gln  Thr Ile Ala Asp Ser  Tyr Val Thr Gln Ser  Leu Gln Leu 
    5645                 5650                 5655             


Leu Asp  Thr Thr Glu Ile Glu  Asn Arg Pro Glu Phe  Ile Thr Glu 
    5660                 5665                 5670             


Phe Ser  Lys Leu Thr Asp Arg  Trp Gln Asn Ala Val  Gln Gly Val 
    5675                 5680                 5685             


Arg Gln  Arg Lys Gly Asp Val  Asp Gly Leu Val Arg  Gln Trp Gln 
    5690                 5695                 5700             


Asp Phe  Thr Thr Ser Val Glu  Asn Leu Phe Arg Phe  Leu Thr Asp 
    5705                 5710                 5715             


Thr Ser  His Leu Leu Ser Ala  Val Lys Gly Gln Glu  Arg Phe Ser 
    5720                 5725                 5730             


Leu Tyr  Gln Thr Arg Ser Leu  Ile His Glu Leu Lys  Asn Lys Glu 
    5735                 5740                 5745             


Ile His  Phe Gln Arg Arg Arg  Thr Thr Cys Ala Leu  Thr Leu Glu 
    5750                 5755                 5760             


Ala Gly  Glu Lys Leu Leu Leu  Thr Thr Asp Leu Lys  Thr Lys Glu 
    5765                 5770                 5775             


Ser Val  Gly Arg Arg Ile Ser  Gln Leu Gln Asp Ser  Trp Lys Asp 
    5780                 5785                 5790             


Met Glu  Pro Gln Leu Ala Glu  Met Ile Lys Gln Phe  Gln Ser Thr 
    5795                 5800                 5805             


Val Glu  Thr Trp Asp Gln Cys  Glu Lys Lys Ile Lys  Glu Leu Lys 
    5810                 5815                 5820             


Ser Arg  Leu Gln Val Leu Lys  Ala Gln Ser Glu Asp  Pro Leu Pro 
    5825                 5830                 5835             


Glu Leu  His Glu Asp Leu His  Asn Glu Lys Glu Leu  Ile Lys Glu 
    5840                 5845                 5850             


Leu Glu  Gln Ser Leu Ala Ser  Trp Thr Gln Asn Leu  Lys Glu Leu 
    5855                 5860                 5865             


Gln Thr  Met Lys Ala Asp Leu  Thr Arg His Val Leu  Val Glu Asp 
    5870                 5875                 5880             


Val Met  Val Leu Lys Glu Gln  Ile Glu His Leu His  Arg Gln Trp 
    5885                 5890                 5895             


Glu Asp  Leu Cys Leu Arg Val  Ala Ile Arg Lys Gln  Glu Ile Glu 
    5900                 5905                 5910             


Asp Arg  Leu Asn Thr Trp Val  Val Phe Asn Glu Lys  Asn Lys Glu 
    5915                 5920                 5925             


Leu Cys  Ala Trp Leu Val Gln  Met Glu Asn Lys Val  Leu Gln Thr 
    5930                 5935                 5940             


Ala Asp  Ile Ser Ile Glu Glu  Met Ile Glu Lys Leu  Gln Lys Asp 
    5945                 5950                 5955             


Cys Met  Glu Glu Ile Asn Leu  Phe Ser Glu Asn Lys  Leu Gln Leu 
    5960                 5965                 5970             


Lys Gln  Met Gly Asp Gln Leu  Ile Lys Ala Ser Asn  Lys Ser Arg 
    5975                 5980                 5985             


Ala Ala  Glu Ile Asp Asp Lys  Leu Asn Lys Ile Asn  Asp Arg Trp 
    5990                 5995                 6000             


Gln His  Leu Phe Asp Val Ile  Gly Ser Arg Val Lys  Lys Leu Lys 
    6005                 6010                 6015             


Glu Thr  Phe Ala Phe Ile Gln  Gln Leu Asp Lys Asn  Met Ser Asn 
    6020                 6025                 6030             


Leu Arg  Thr Trp Leu Ala Arg  Ile Glu Ser Glu Leu  Ser Lys Pro 
    6035                 6040                 6045             


Val Val  Tyr Asp Val Cys Asp  Asp Gln Glu Ile Gln  Lys Arg Leu 
    6050                 6055                 6060             


Ala Glu  Gln Gln Asp Leu Gln  Arg Asp Ile Glu Gln  His Ser Ala 
    6065                 6070                 6075             


Gly Val  Glu Ser Val Phe Asn  Ile Cys Asp Val Leu  Leu His Asp 
    6080                 6085                 6090             


Ser Asp  Ala Cys Ala Asn Glu  Thr Glu Cys Asp Ser  Ile Gln Gln 
    6095                 6100                 6105             


Thr Thr  Arg Ser Leu Asp Arg  Arg Trp Arg Asn Ile  Cys Ala Met 
    6110                 6115                 6120             


Ser Met  Glu Arg Arg Met Lys  Ile Glu Glu Thr Trp  Arg Leu Trp 
    6125                 6130                 6135             


Gln Lys  Phe Leu Asp Asp Tyr  Ser Arg Phe Glu Asp  Trp Leu Lys 
    6140                 6145                 6150             


Ser Ala  Glu Arg Thr Ala Ala  Cys Pro Asn Ser Ser  Glu Val Leu 
    6155                 6160                 6165             


Tyr Thr  Ser Ala Lys Glu Glu  Leu Lys Arg Phe Glu  Ala Phe Gln 
    6170                 6175                 6180             


Arg Gln  Ile His Glu Arg Leu  Thr Gln Leu Glu Leu  Ile Asn Lys 
    6185                 6190                 6195             


Gln Tyr  Arg Arg Leu Ala Arg  Glu Asn Arg Thr Asp  Thr Ala Ser 
    6200                 6205                 6210             


Arg Leu  Lys Gln Met Val His  Glu Gly Asn Gln Arg  Trp Asp Asn 
    6215                 6220                 6225             


Leu Gln  Arg Arg Val Thr Ala  Val Leu Arg Arg Leu  Arg His Phe 
    6230                 6235                 6240             


Thr Asn  Gln Arg Glu Glu Phe  Glu Gly Thr Arg Glu  Ser Ile Leu 
    6245                 6250                 6255             


Val Trp  Leu Thr Glu Met Asp  Leu Gln Leu Thr Asn  Val Glu His 
    6260                 6265                 6270             


Phe Ser  Glu Ser Asp Ala Asp  Asp Lys Met Arg Gln  Leu Asn Gly 
    6275                 6280                 6285             


Phe Gln  Gln Glu Ile Thr Leu  Asn Thr Asn Lys Ile  Asp Gln Leu 
    6290                 6295                 6300             


Ile Val  Phe Gly Glu Gln Leu  Ile Gln Lys Ser Glu  Pro Leu Asp 
    6305                 6310                 6315             


Ala Val  Leu Ile Glu Asp Glu  Leu Glu Glu Leu His  Arg Tyr Cys 
    6320                 6325                 6330             


Gln Glu  Val Phe Gly Arg Val  Ser Arg Phe His Arg  Arg Leu Thr 
    6335                 6340                 6345             


Ser Cys  Thr Pro Gly Leu Glu  Asp Glu Lys Glu Ala  Ser Glu Asn 
    6350                 6355                 6360             


Glu Thr  Asp Met Glu Asp Pro  Arg Glu Ile Gln Thr  Asp Ser Trp 
    6365                 6370                 6375             


Arg Lys  Arg Gly Glu Ser Glu  Glu Pro Ser Ser Pro  Gln Ser Leu 
    6380                 6385                 6390             


Cys His  Leu Val Ala Pro Gly  His Glu Arg Ser Gly  Cys Glu Thr 
    6395                 6400                 6405             


Pro Val  Ser Val Asp Ser Ile  Pro Leu Glu Trp Asp  His Thr Gly 
    6410                 6415                 6420             


Asp Val  Gly Gly Ser Ser Ser  His Glu Glu Asp Glu  Glu Gly Pro 
    6425                 6430                 6435             


Tyr Tyr  Ser Ala Leu Ser Gly  Lys Ser Ile Ser Asp  Gly His Ser 
    6440                 6445                 6450             


Trp His  Val Pro Asp Ser Pro  Ser Cys Pro Glu His  His Tyr Lys 
    6455                 6460                 6465             


Gln Met  Glu Gly Asp Arg Asn  Val Pro Pro Val Pro  Pro Ala Ser 
    6470                 6475                 6480             


Ser Thr  Pro Tyr Lys Pro Pro  Tyr Gly Lys Leu Leu  Leu Pro Pro 
    6485                 6490                 6495             


Gly Thr  Asp Gly Gly Lys Glu  Gly Pro Arg Val Leu  Asn Gly Asn 
    6500                 6505                 6510             


Pro Gln  Gln Glu Asp Gly Gly  Leu Ala Gly Ile Thr  Glu Gln Gln 
    6515                 6520                 6525             


Ser Gly  Ala Phe Asp Arg Trp  Glu Met Ile Gln Ala  Gln Glu Leu 
    6530                 6535                 6540             


His Asn  Lys Leu Lys Ile Lys  Gln Asn Leu Gln Gln  Leu Asn Ser 
    6545                 6550                 6555             


Asp Ile  Ser Ala Ile Thr Thr  Trp Leu Lys Lys Thr  Glu Ala Glu 
    6560                 6565                 6570             


Leu Glu  Met Leu Lys Met Ala  Lys Pro Pro Ser Asp  Ile Gln Glu 
    6575                 6580                 6585             


Ile Glu  Leu Arg Val Lys Arg  Leu Gln Glu Ile Leu  Lys Ala Phe 
    6590                 6595                 6600             


Asp Thr  Tyr Lys Ala Leu Val  Val Ser Val Asn Val  Ser Ser Lys 
    6605                 6610                 6615             


Glu Phe  Leu Gln Thr Glu Ser  Pro Glu Ser Thr Glu  Leu Gln Ser 
    6620                 6625                 6630             


Arg Leu  Arg Gln Leu Ser Leu  Leu Trp Glu Ala Ala  Gln Gly Ala 
    6635                 6640                 6645             


Val Asp  Ser Trp Arg Gly Gly  Leu Arg Gln Ser Leu  Met Gln Cys 
    6650                 6655                 6660             


Gln Asp  Phe His Gln Leu Ser  Gln Asn Leu Leu Leu  Trp Leu Ala 
    6665                 6670                 6675             


Ser Ala  Lys Asn Arg Arg Gln  Lys Ala His Val Thr  Asp Pro Lys 
    6680                 6685                 6690             


Ala Asp  Pro Arg Ala Leu Leu  Glu Cys Arg Arg Glu  Leu Met Gln 
    6695                 6700                 6705             


Leu Glu  Lys Glu Leu Val Glu  Arg Gln Pro Gln Val  Asp Met Leu 
    6710                 6715                 6720             


Gln Glu  Ile Ser Asn Ser Leu  Leu Ile Lys Gly His  Gly Glu Asp 
    6725                 6730                 6735             


Cys Ile  Glu Ala Glu Glu Lys  Val His Val Ile Glu  Lys Lys Leu 
    6740                 6745                 6750             


Lys Gln  Leu Arg Glu Gln Val  Ser Gln Asp Leu Met  Ala Leu Gln 
    6755                 6760                 6765             


Gly Thr  Gln Asn Pro Ala Ser  Pro Leu Pro Ser Phe  Asp Glu Val 
    6770                 6775                 6780             


Asp Ser  Gly Asp Gln Pro Pro  Ala Thr Ser Val Pro  Ala Pro Arg 
    6785                 6790                 6795             


Ala Lys  Gln Phe Arg Ala Val  Arg Thr Thr Glu Gly  Glu Glu Glu 
    6800                 6805                 6810             


Thr Glu  Ser Arg Val Pro Gly  Ser Thr Arg Pro Gln  Arg Ser Phe 
    6815                 6820                 6825             


Leu Ser  Arg Val Val Arg Ala  Ala Leu Pro Leu Gln  Leu Leu Leu 
    6830                 6835                 6840             


Leu Leu  Leu Leu Leu Leu Ala  Cys Leu Leu Pro Ser  Ser Glu Glu 
    6845                 6850                 6855             


Asp Tyr  Ser Cys Thr Gln Ala  Asn Asn Phe Ala Arg  Ser Phe Tyr 
    6860                 6865                 6870             


Pro Met  Leu Arg Tyr Thr Asn  Gly Pro Pro Pro Thr  
    6875                 6880                 6885 


<210>  97
<211>  2364
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Thr Thr Thr Val Ala Thr Asp Tyr Asp Asn Ile Glu Ile Gln Gln 
1               5                   10                  15      


Gln Tyr Ser Asp Val Asn Asn Arg Trp Asp Val Asp Asp Trp Asp Asn 
            20                  25                  30          


Glu Asn Ser Ser Ala Arg Leu Phe Glu Arg Ser Arg Ile Lys Ala Leu 
        35                  40                  45              


Ala Asp Glu Arg Glu Ala Val Gln Lys Lys Thr Phe Thr Lys Trp Val 
    50                  55                  60                  


Asn Ser His Leu Ala Arg Val Ser Cys Arg Ile Thr Asp Leu Tyr Thr 
65                  70                  75                  80  


Asp Leu Arg Asp Gly Arg Met Leu Ile Lys Leu Leu Glu Val Leu Ser 
                85                  90                  95      


Gly Glu Arg Leu Pro Lys Pro Thr Lys Gly Arg Met Arg Ile His Cys 
            100                 105                 110         


Leu Glu Asn Val Asp Lys Ala Leu Gln Phe Leu Lys Glu Gln Arg Val 
        115                 120                 125             


His Leu Glu Asn Met Gly Ser His Asp Ile Val Asp Gly Asn His Arg 
    130                 135                 140                 


Leu Thr Leu Gly Leu Ile Trp Thr Ile Ile Leu Arg Phe Gln Ile Gln 
145                 150                 155                 160 


Asp Ile Ser Val Glu Thr Glu Asp Asn Lys Glu Lys Lys Ser Ala Lys 
                165                 170                 175     


Asp Ala Leu Leu Leu Trp Cys Gln Met Lys Thr Ala Gly Tyr Pro Asn 
            180                 185                 190         


Val Asn Ile His Asn Phe Thr Thr Ser Trp Arg Asp Gly Met Ala Phe 
        195                 200                 205             


Asn Ala Leu Ile His Lys His Arg Pro Asp Leu Ile Asp Phe Asp Lys 
    210                 215                 220                 


Leu Lys Lys Ser Asn Ala His Tyr Asn Leu Gln Asn Ala Phe Asn Leu 
225                 230                 235                 240 


Ala Glu Gln His Leu Gly Leu Thr Lys Leu Leu Asp Pro Glu Asp Ile 
                245                 250                 255     


Ser Val Asp His Pro Asp Glu Lys Ser Ile Ile Thr Tyr Val Val Thr 
            260                 265                 270         


Tyr Tyr His Tyr Phe Ser Lys Met Lys Ala Leu Ala Val Glu Gly Lys 
        275                 280                 285             


Arg Ile Gly Lys Val Leu Asp Asn Ala Ile Glu Thr Glu Lys Met Ile 
    290                 295                 300                 


Glu Lys Tyr Glu Ser Leu Ala Ser Asp Leu Leu Glu Trp Ile Glu Gln 
305                 310                 315                 320 


Thr Ile Ile Ile Leu Asn Asn Arg Lys Phe Ala Asn Ser Leu Val Gly 
                325                 330                 335     


Val Gln Gln Gln Leu Gln Ala Phe Asn Thr Tyr Arg Thr Val Glu Lys 
            340                 345                 350         


Pro Pro Lys Phe Thr Glu Lys Gly Asn Leu Glu Val Leu Leu Phe Thr 
        355                 360                 365             


Ile Gln Ser Lys Met Arg Ala Asn Asn Gln Lys Val Tyr Met Pro Arg 
    370                 375                 380                 


Glu Gly Lys Leu Ile Ser Asp Ile Asn Lys Ala Trp Glu Arg Leu Glu 
385                 390                 395                 400 


Lys Ala Glu His Glu Arg Glu Leu Ala Leu Arg Asn Glu Leu Ile Arg 
                405                 410                 415     


Gln Glu Lys Leu Glu Gln Leu Ala Arg Arg Phe Asp Arg Lys Ala Ala 
            420                 425                 430         


Met Arg Glu Thr Trp Leu Ser Glu Asn Gln Arg Leu Val Ser Gln Asp 
        435                 440                 445             


Asn Phe Gly Phe Asp Leu Pro Ala Val Glu Ala Ala Thr Lys Lys His 
    450                 455                 460                 


Glu Ala Ile Glu Thr Asp Ile Ala Ala Tyr Glu Glu Arg Val Gln Ala 
465                 470                 475                 480 


Val Val Ala Val Ala Arg Glu Leu Glu Ala Glu Asn Tyr His Asp Ile 
                485                 490                 495     


Lys Arg Ile Thr Ala Arg Lys Asp Asn Val Ile Arg Leu Trp Glu Tyr 
            500                 505                 510         


Leu Leu Glu Leu Leu Arg Ala Arg Arg Gln Arg Leu Glu Met Asn Leu 
        515                 520                 525             


Gly Leu Gln Lys Ile Phe Gln Glu Met Leu Tyr Ile Met Asp Trp Met 
    530                 535                 540                 


Asp Glu Met Lys Val Leu Val Leu Ser Gln Asp Tyr Gly Lys His Leu 
545                 550                 555                 560 


Leu Gly Val Glu Asp Leu Leu Gln Lys His Thr Leu Val Glu Ala Asp 
                565                 570                 575     


Ile Gly Ile Gln Ala Glu Arg Val Arg Gly Val Asn Ala Ser Ala Gln 
            580                 585                 590         


Lys Phe Ala Thr Asp Gly Glu Gly Tyr Lys Pro Cys Asp Pro Gln Val 
        595                 600                 605             


Ile Arg Asp Arg Val Ala His Met Glu Phe Cys Tyr Gln Glu Leu Cys 
    610                 615                 620                 


Gln Leu Ala Ala Glu Arg Arg Ala Arg Leu Glu Glu Ser Arg Arg Leu 
625                 630                 635                 640 


Trp Lys Phe Phe Trp Glu Met Ala Glu Glu Glu Gly Trp Ile Arg Glu 
                645                 650                 655     


Lys Glu Lys Ile Leu Ser Ser Asp Asp Tyr Gly Lys Asp Leu Thr Ser 
            660                 665                 670         


Val Met Arg Leu Leu Ser Lys His Arg Ala Phe Glu Asp Glu Met Ser 
        675                 680                 685             


Gly Arg Ser Gly His Phe Glu Gln Ala Ile Lys Glu Gly Glu Asp Met 
    690                 695                 700                 


Ile Ala Glu Glu His Phe Gly Ser Glu Lys Ile Arg Glu Arg Ile Ile 
705                 710                 715                 720 


Tyr Ile Arg Glu Gln Trp Ala Asn Leu Glu Gln Leu Ser Ala Ile Arg 
                725                 730                 735     


Lys Lys Arg Leu Glu Glu Ala Ser Leu Leu His Gln Phe Gln Ala Asp 
            740                 745                 750         


Ala Asp Asp Ile Asp Ala Trp Met Leu Asp Ile Leu Lys Ile Val Ser 
        755                 760                 765             


Ser Ser Asp Val Gly His Asp Glu Tyr Ser Thr Gln Ser Leu Val Lys 
    770                 775                 780                 


Lys His Lys Asp Val Ala Glu Glu Ile Ala Asn Tyr Arg Pro Thr Leu 
785                 790                 795                 800 


Asp Thr Leu His Glu Gln Ala Ser Ala Leu Pro Gln Glu His Ala Glu 
                805                 810                 815     


Ser Pro Asp Val Arg Gly Arg Leu Ser Gly Ile Glu Glu Arg Tyr Lys 
            820                 825                 830         


Glu Val Ala Glu Leu Thr Arg Leu Arg Lys Gln Ala Leu Gln Asp Thr 
        835                 840                 845             


Leu Ala Leu Tyr Lys Met Phe Ser Glu Ala Asp Ala Cys Glu Leu Trp 
    850                 855                 860                 


Ile Asp Glu Lys Glu Gln Trp Leu Asn Asn Met Gln Ile Pro Glu Lys 
865                 870                 875                 880 


Leu Glu Asp Leu Glu Val Ile Gln His Arg Phe Glu Ser Leu Glu Pro 
                885                 890                 895     


Glu Met Asn Asn Gln Ala Ser Arg Val Ala Val Val Asn Gln Ile Ala 
            900                 905                 910         


Arg Gln Leu Met His Ser Gly His Pro Ser Glu Lys Glu Ile Lys Ala 
        915                 920                 925             


Gln Gln Asp Lys Leu Asn Thr Arg Trp Ser Gln Phe Arg Glu Leu Val 
    930                 935                 940                 


Asp Arg Lys Lys Asp Ala Leu Leu Ser Ala Leu Ser Ile Gln Asn Tyr 
945                 950                 955                 960 


His Leu Glu Cys Asn Glu Thr Lys Ser Trp Ile Arg Glu Lys Thr Lys 
                965                 970                 975     


Val Ile Glu Ser Thr Gln Asp Leu Gly Asn Asp Leu Ala Gly Val Met 
            980                 985                 990         


Ala Leu Gln Arg Lys Leu Thr Gly  Met Glu Arg Asp Leu  Val Ala Ile 
        995                 1000                 1005             


Glu Ala  Lys Leu Ser Asp Leu  Gln Lys Glu Ala Glu  Lys Leu Glu 
    1010                 1015                 1020             


Ser Glu  His Pro Asp Gln Ala  Gln Ala Ile Leu Ser  Arg Leu Ala 
    1025                 1030                 1035             


Glu Ile  Ser Asp Val Trp Glu  Glu Met Lys Thr Thr  Leu Lys Asn 
    1040                 1045                 1050             


Arg Glu  Ala Ser Leu Gly Glu  Ala Ser Lys Leu Gln  Gln Phe Leu 
    1055                 1060                 1065             


Arg Asp  Leu Asp Asp Phe Gln  Ser Trp Leu Ser Arg  Thr Gln Thr 
    1070                 1075                 1080             


Ala Ile  Ala Ser Glu Asp Met  Pro Asn Thr Leu Thr  Glu Ala Glu 
    1085                 1090                 1095             


Lys Leu  Leu Thr Gln His Glu  Asn Ile Lys Asn Glu  Ile Asp Asn 
    1100                 1105                 1110             


Tyr Glu  Glu Asp Tyr Gln Lys  Met Arg Asp Met Gly  Glu Met Val 
    1115                 1120                 1125             


Thr Gln  Gly Gln Thr Asp Ala  Gln Tyr Met Phe Leu  Arg Gln Arg 
    1130                 1135                 1140             


Leu Gln  Ala Leu Asp Thr Gly  Trp Asn Glu Leu His  Lys Met Trp 
    1145                 1150                 1155             


Glu Asn  Arg Gln Asn Leu Leu  Ser Gln Ser His Ala  Tyr Gln Gln 
    1160                 1165                 1170             


Phe Leu  Arg Asp Thr Lys Gln  Ala Glu Ala Phe Leu  Asn Asn Gln 
    1175                 1180                 1185             


Glu Tyr  Val Leu Ala His Thr  Glu Met Pro Thr Thr  Leu Glu Gly 
    1190                 1195                 1200             


Ala Glu  Ala Ala Ile Lys Lys  Gln Glu Asp Phe Met  Thr Thr Met 
    1205                 1210                 1215             


Asp Ala  Asn Glu Glu Lys Ile  Asn Ala Val Val Glu  Thr Gly Arg 
    1220                 1225                 1230             


Arg Leu  Val Ser Asp Gly Asn  Ile Asn Ser Asp Arg  Ile Gln Glu 
    1235                 1240                 1245             


Lys Val  Asp Ser Ile Asp Asp  Arg His Arg Lys Asn  Arg Glu Thr 
    1250                 1255                 1260             


Ala Ser  Glu Leu Leu Met Arg  Leu Lys Asp Asn Arg  Asp Leu Gln 
    1265                 1270                 1275             


Lys Phe  Leu Gln Asp Cys Gln  Glu Leu Ser Leu Trp  Ile Asn Glu 
    1280                 1285                 1290             


Lys Met  Leu Thr Ala Gln Asp  Met Ser Tyr Asp Glu  Ala Arg Asn 
    1295                 1300                 1305             


Leu His  Ser Lys Trp Leu Lys  His Gln Ala Phe Met  Ala Glu Leu 
    1310                 1315                 1320             


Ala Ser  Asn Lys Glu Trp Leu  Asp Lys Ile Glu Lys  Glu Gly Met 
    1325                 1330                 1335             


Gln Leu  Ile Ser Glu Lys Pro  Glu Thr Glu Ala Val  Val Lys Glu 
    1340                 1345                 1350             


Lys Leu  Thr Gly Leu His Lys  Met Trp Glu Val Leu  Glu Ser Thr 
    1355                 1360                 1365             


Thr Gln  Thr Lys Ala Gln Arg  Leu Phe Asp Ala Asn  Lys Ala Glu 
    1370                 1375                 1380             


Leu Phe  Thr Gln Ser Cys Ala  Asp Leu Asp Lys Trp  Leu His Gly 
    1385                 1390                 1395             


Leu Glu  Ser Gln Ile Gln Ser  Asp Asp Tyr Gly Lys  Asp Leu Thr 
    1400                 1405                 1410             


Ser Val  Asn Ile Leu Leu Lys  Lys Gln Gln Met Leu  Glu Asn Gln 
    1415                 1420                 1425             


Met Glu  Val Arg Lys Lys Glu  Ile Glu Glu Leu Gln  Ser Gln Ala 
    1430                 1435                 1440             


Gln Ala  Leu Ser Gln Glu Gly  Lys Ser Thr Asp Glu  Val Asp Ser 
    1445                 1450                 1455             


Lys Arg  Leu Thr Val Gln Thr  Lys Phe Met Glu Leu  Leu Glu Pro 
    1460                 1465                 1470             


Leu Asn  Glu Arg Lys His Asn  Leu Leu Ala Ser Lys  Glu Ile His 
    1475                 1480                 1485             


Gln Phe  Asn Arg Asp Val Glu  Asp Glu Ile Leu Trp  Val Gly Glu 
    1490                 1495                 1500             


Arg Met  Pro Leu Ala Thr Ser  Thr Asp His Gly His  Asn Leu Gln 
    1505                 1510                 1515             


Thr Val  Gln Leu Leu Ile Lys  Lys Asn Gln Thr Leu  Gln Lys Glu 
    1520                 1525                 1530             


Ile Gln  Gly His Gln Pro Arg  Ile Asp Asp Ile Phe  Glu Arg Ser 
    1535                 1540                 1545             


Gln Asn  Ile Val Thr Asp Ser  Ser Ser Leu Ser Ala  Glu Ala Ile 
    1550                 1555                 1560             


Arg Gln  Arg Leu Ala Asp Leu  Lys Gln Leu Trp Gly  Leu Leu Ile 
    1565                 1570                 1575             


Glu Glu  Thr Glu Lys Arg His  Arg Arg Leu Glu Glu  Ala His Arg 
    1580                 1585                 1590             


Ala Gln  Gln Tyr Tyr Phe Asp  Ala Ala Glu Ala Glu  Ala Trp Met 
    1595                 1600                 1605             


Ser Glu  Gln Glu Leu Tyr Met  Met Ser Glu Glu Lys  Ala Lys Asp 
    1610                 1615                 1620             


Glu Gln  Ser Ala Val Ser Met  Leu Lys Lys His Gln  Ile Leu Glu 
    1625                 1630                 1635             


Gln Ala  Val Glu Asp Tyr Ala  Glu Thr Val His Gln  Leu Ser Lys 
    1640                 1645                 1650             


Thr Ser  Arg Ala Leu Val Ala  Asp Ser His Pro Glu  Ser Glu Arg 
    1655                 1660                 1665             


Ile Ser  Met Arg Gln Ser Lys  Val Asp Lys Leu Tyr  Ala Gly Leu 
    1670                 1675                 1680             


Lys Asp  Leu Ala Glu Glu Arg  Arg Gly Lys Leu Asp  Glu Arg His 
    1685                 1690                 1695             


Arg Leu  Phe Gln Leu Asn Arg  Glu Val Asp Asp Leu  Glu Gln Trp 
    1700                 1705                 1710             


Ile Ala  Glu Arg Glu Val Val  Ala Gly Ser His Glu  Leu Gly Gln 
    1715                 1720                 1725             


Asp Tyr  Glu His Val Thr Met  Leu Gln Glu Arg Phe  Arg Glu Phe 
    1730                 1735                 1740             


Ala Arg  Asp Thr Gly Asn Ile  Gly Gln Glu Arg Val  Asp Thr Val 
    1745                 1750                 1755             


Asn His  Leu Ala Asp Glu Leu  Ile Asn Ser Gly His  Ser Asp Ala 
    1760                 1765                 1770             


Ala Thr  Ile Ala Glu Trp Lys  Asp Gly Leu Asn Glu  Ala Trp Ala 
    1775                 1780                 1785             


Asp Leu  Leu Glu Leu Ile Asp  Thr Arg Thr Gln Ile  Leu Ala Ala 
    1790                 1795                 1800             


Ser Tyr  Glu Leu His Lys Phe  Tyr His Asp Ala Lys  Glu Ile Phe 
    1805                 1810                 1815             


Gly Arg  Ile Gln Asp Lys His  Lys Lys Leu Pro Glu  Glu Leu Gly 
    1820                 1825                 1830             


Arg Asp  Gln Asn Thr Val Glu  Thr Leu Gln Arg Met  His Thr Thr 
    1835                 1840                 1845             


Phe Glu  His Asp Ile Gln Ala  Leu Gly Thr Gln Val  Arg Gln Leu 
    1850                 1855                 1860             


Gln Glu  Asp Ala Ala Arg Leu  Gln Ala Ala Tyr Ala  Gly Asp Lys 
    1865                 1870                 1875             


Ala Asp  Asp Ile Gln Lys Arg  Glu Asn Glu Val Leu  Glu Ala Trp 
    1880                 1885                 1890             


Lys Ser  Leu Leu Asp Ala Cys  Glu Ser Arg Arg Val  Arg Leu Val 
    1895                 1900                 1905             


Asp Thr  Gly Asp Lys Phe Arg  Phe Phe Ser Met Val  Arg Asp Leu 
    1910                 1915                 1920             


Met Leu  Trp Met Glu Asp Val  Ile Arg Gln Ile Glu  Ala Gln Glu 
    1925                 1930                 1935             


Lys Pro  Arg Asp Val Ser Ser  Val Glu Leu Leu Met  Asn Asn His 
    1940                 1945                 1950             


Gln Gly  Ile Lys Ala Glu Ile  Asp Ala Arg Asn Asp  Ser Phe Thr 
    1955                 1960                 1965             


Thr Cys  Ile Glu Leu Gly Lys  Ser Leu Leu Ala Arg  Lys His Tyr 
    1970                 1975                 1980             


Ala Ser  Glu Glu Ile Lys Glu  Lys Leu Leu Gln Leu  Thr Glu Lys 
    1985                 1990                 1995             


Arg Lys  Glu Met Ile Asp Lys  Trp Glu Asp Arg Trp  Glu Trp Leu 
    2000                 2005                 2010             


Arg Leu  Ile Leu Glu Val His  Gln Phe Ser Arg Asp  Ala Ser Val 
    2015                 2020                 2025             


Ala Glu  Ala Trp Leu Leu Gly  Gln Glu Pro Tyr Leu  Ser Ser Arg 
    2030                 2035                 2040             


Glu Ile  Gly Gln Ser Val Asp  Glu Val Glu Lys Leu  Ile Lys Arg 
    2045                 2050                 2055             


His Glu  Ala Phe Glu Lys Ser  Ala Ala Thr Trp Asp  Glu Arg Phe 
    2060                 2065                 2070             


Ser Ala  Leu Glu Arg Leu Thr  Thr Leu Glu Leu Leu  Glu Val Arg 
    2075                 2080                 2085             


Arg Gln  Gln Glu Glu Glu Glu  Arg Lys Arg Arg Pro  Pro Ser Pro 
    2090                 2095                 2100             


Glu Pro  Ser Thr Lys Val Ser  Glu Glu Ala Glu Ser  Gln Gln Gln 
    2105                 2110                 2115             


Trp Asp  Thr Ser Lys Gly Glu  Gln Val Ser Gln Asn  Gly Leu Pro 
    2120                 2125                 2130             


Ala Glu  Gln Gly Ser Pro Arg  Met Ala Glu Thr Val  Asp Thr Ser 
    2135                 2140                 2145             


Glu Met  Val Asn Gly Ala Thr  Glu Gln Arg Thr Ser  Ser Lys Glu 
    2150                 2155                 2160             


Ser Ser  Pro Ile Pro Ser Pro  Thr Ser Asp Arg Lys  Ala Lys Thr 
    2165                 2170                 2175             


Ala Leu  Pro Ala Gln Ser Ala  Ala Thr Leu Pro Ala  Arg Thr Gln 
    2180                 2185                 2190             


Glu Thr  Pro Ser Ala Gln Met  Glu Gly Phe Leu Asn  Arg Lys His 
    2195                 2200                 2205             


Glu Trp  Glu Ala His Asn Lys  Lys Ala Ser Ser Arg  Ser Trp His 
    2210                 2215                 2220             


Asn Val  Tyr Cys Val Ile Asn  Asn Gln Glu Met Gly  Phe Tyr Lys 
    2225                 2230                 2235             


Asp Ala  Lys Thr Ala Ala Ser  Gly Ile Pro Tyr His  Ser Glu Val 
    2240                 2245                 2250             


Pro Val  Ser Leu Lys Glu Ala  Val Cys Glu Val Ala  Leu Asp Tyr 
    2255                 2260                 2265             


Lys Lys  Lys Lys His Val Phe  Lys Leu Arg Leu Asn  Asp Gly Asn 
    2270                 2275                 2280             


Glu Tyr  Leu Phe Gln Ala Lys  Asp Asp Glu Glu Met  Asn Thr Trp 
    2285                 2290                 2295             


Ile Gln  Ala Ile Ser Ser Ala  Ile Ser Ser Asp Lys  His Glu Val 
    2300                 2305                 2310             


Ser Ala  Ser Thr Gln Ser Thr  Pro Ala Ser Ser Arg  Ala Gln Thr 
    2315                 2320                 2325             


Leu Pro  Thr Ser Val Val Thr  Ile Thr Ser Glu Ser  Ser Pro Gly 
    2330                 2335                 2340             


Lys Arg  Glu Lys Asp Lys Glu  Lys Asp Lys Glu Lys  Arg Phe Ser 
    2345                 2350                 2355             


Leu Phe  Gly Lys Lys Lys 
    2360                 


<210>  98
<211>  1217
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Phe Leu Tyr Asn Leu Thr Leu Gln Arg Ala Thr Gly Ile Ser Phe 
1               5                   10                  15      


Ala Ile His Gly Asn Phe Ser Gly Thr Lys Gln Gln Glu Ile Val Val 
            20                  25                  30          


Ser Arg Gly Lys Ile Leu Glu Leu Leu Arg Pro Asp Pro Asn Thr Gly 
        35                  40                  45              


Lys Val His Thr Leu Leu Thr Val Glu Val Phe Gly Val Ile Arg Ser 
    50                  55                  60                  


Leu Met Ala Phe Arg Leu Thr Gly Gly Thr Lys Asp Tyr Ile Val Val 
65                  70                  75                  80  


Gly Ser Asp Ser Gly Arg Ile Val Ile Leu Glu Tyr Gln Pro Ser Lys 
                85                  90                  95      


Asn Met Phe Glu Lys Ile His Gln Glu Thr Phe Gly Lys Ser Gly Cys 
            100                 105                 110         


Arg Arg Ile Val Pro Gly Gln Phe Leu Ala Val Asp Pro Lys Gly Arg 
        115                 120                 125             


Ala Val Met Ile Ser Ala Ile Glu Lys Gln Lys Leu Val Tyr Ile Leu 
    130                 135                 140                 


Asn Arg Asp Ala Ala Ala Arg Leu Thr Ile Ser Ser Pro Leu Glu Ala 
145                 150                 155                 160 


His Lys Ala Asn Thr Leu Val Tyr His Val Val Gly Val Asp Val Gly 
                165                 170                 175     


Phe Glu Asn Pro Met Phe Ala Cys Leu Glu Met Asp Tyr Glu Glu Ala 
            180                 185                 190         


Asp Asn Asp Pro Thr Gly Glu Ala Ala Ala Asn Thr Gln Gln Thr Leu 
        195                 200                 205             


Thr Phe Tyr Glu Leu Asp Leu Gly Leu Asn His Val Val Arg Lys Tyr 
    210                 215                 220                 


Ser Glu Pro Leu Glu Glu His Gly Asn Phe Leu Ile Thr Val Pro Gly 
225                 230                 235                 240 


Gly Ser Asp Gly Pro Ser Gly Val Leu Ile Cys Ser Glu Asn Tyr Ile 
                245                 250                 255     


Thr Tyr Lys Asn Phe Gly Asp Gln Pro Asp Ile Arg Cys Pro Ile Pro 
            260                 265                 270         


Arg Arg Arg Asn Asp Leu Asp Asp Pro Glu Arg Gly Met Ile Phe Val 
        275                 280                 285             


Cys Ser Ala Thr His Lys Thr Lys Ser Met Phe Phe Phe Leu Ala Gln 
    290                 295                 300                 


Thr Glu Gln Gly Asp Ile Phe Lys Ile Thr Leu Glu Thr Asp Glu Asp 
305                 310                 315                 320 


Met Val Thr Glu Ile Arg Leu Lys Tyr Phe Asp Thr Val Pro Val Ala 
                325                 330                 335     


Ala Ala Met Cys Val Leu Lys Thr Gly Phe Leu Phe Val Ala Ser Glu 
            340                 345                 350         


Phe Gly Asn His Tyr Leu Tyr Gln Ile Ala His Leu Gly Asp Asp Asp 
        355                 360                 365             


Glu Glu Pro Glu Phe Ser Ser Ala Met Pro Leu Glu Glu Gly Asp Thr 
    370                 375                 380                 


Phe Phe Phe Gln Pro Arg Pro Leu Lys Asn Leu Val Leu Val Asp Glu 
385                 390                 395                 400 


Leu Asp Ser Leu Ser Pro Ile Leu Phe Cys Gln Ile Ala Asp Leu Ala 
                405                 410                 415     


Asn Glu Asp Thr Pro Gln Leu Tyr Val Ala Cys Gly Arg Gly Pro Arg 
            420                 425                 430         


Ser Ser Leu Arg Val Leu Arg His Gly Leu Glu Val Ser Glu Met Ala 
        435                 440                 445             


Val Ser Glu Leu Pro Gly Asn Pro Asn Ala Val Trp Thr Val Arg Arg 
    450                 455                 460                 


His Ile Glu Asp Glu Phe Asp Ala Tyr Ile Ile Val Ser Phe Val Asn 
465                 470                 475                 480 


Ala Thr Leu Val Leu Ser Ile Gly Glu Thr Val Glu Glu Val Thr Asp 
                485                 490                 495     


Ser Gly Phe Leu Gly Thr Thr Pro Thr Leu Ser Cys Ser Leu Leu Gly 
            500                 505                 510         


Asp Asp Ala Leu Val Gln Val Tyr Pro Asp Gly Ile Arg His Ile Arg 
        515                 520                 525             


Ala Asp Lys Arg Val Asn Glu Trp Lys Thr Pro Gly Lys Lys Thr Ile 
    530                 535                 540                 


Val Lys Cys Ala Val Asn Gln Arg Gln Val Val Ile Ala Leu Thr Gly 
545                 550                 555                 560 


Gly Glu Leu Val Tyr Phe Glu Met Asp Pro Ser Gly Gln Leu Asn Glu 
                565                 570                 575     


Tyr Thr Glu Arg Lys Glu Met Ser Ala Asp Val Val Cys Met Ser Leu 
            580                 585                 590         


Ala Asn Val Pro Pro Gly Glu Gln Arg Ser Arg Phe Leu Ala Val Gly 
        595                 600                 605             


Leu Val Asp Asn Thr Val Arg Ile Ile Ser Leu Asp Pro Ser Asp Cys 
    610                 615                 620                 


Leu Gln Pro Leu Ser Met Gln Ala Leu Pro Ala Gln Pro Glu Ser Leu 
625                 630                 635                 640 


Cys Ile Val Glu Met Gly Gly Thr Glu Lys Gln Asp Glu Leu Gly Glu 
                645                 650                 655     


Arg Gly Ser Ile Gly Phe Leu Tyr Leu Asn Ile Gly Leu Gln Asn Gly 
            660                 665                 670         


Val Leu Leu Arg Thr Val Leu Asp Pro Val Thr Gly Asp Leu Ser Asp 
        675                 680                 685             


Thr Arg Thr Arg Tyr Leu Gly Ser Arg Pro Val Lys Leu Phe Arg Val 
    690                 695                 700                 


Arg Met Gln Gly Gln Glu Ala Val Leu Ala Met Ser Ser Arg Ser Trp 
705                 710                 715                 720 


Leu Ser Tyr Ser Tyr Gln Ser Arg Phe His Leu Thr Pro Leu Ser Tyr 
                725                 730                 735     


Glu Thr Leu Glu Phe Ala Ser Gly Phe Ala Ser Glu Gln Cys Pro Glu 
            740                 745                 750         


Gly Ile Val Ala Ile Ser Thr Asn Thr Leu Arg Ile Leu Ala Leu Glu 
        755                 760                 765             


Lys Leu Gly Ala Val Phe Asn Gln Val Ala Phe Pro Leu Gln Tyr Thr 
    770                 775                 780                 


Pro Arg Lys Phe Val Ile His Pro Glu Ser Asn Asn Leu Ile Ile Ile 
785                 790                 795                 800 


Glu Thr Asp His Asn Ala Tyr Thr Glu Ala Thr Lys Ala Gln Arg Lys 
                805                 810                 815     


Gln Gln Met Ala Glu Glu Met Val Glu Ala Ala Gly Glu Asp Glu Arg 
            820                 825                 830         


Glu Leu Ala Ala Glu Met Ala Ala Ala Phe Leu Asn Glu Asn Leu Pro 
        835                 840                 845             


Glu Ser Ile Phe Gly Ala Pro Lys Ala Gly Asn Gly Gln Trp Ala Ser 
    850                 855                 860                 


Val Ile Arg Val Met Asn Pro Ile Gln Gly Asn Thr Leu Asp Leu Val 
865                 870                 875                 880 


Gln Leu Glu Gln Asn Glu Ala Ala Phe Ser Val Ala Val Cys Arg Phe 
                885                 890                 895     


Ser Asn Thr Gly Glu Asp Trp Tyr Val Leu Val Gly Val Ala Lys Asp 
            900                 905                 910         


Leu Ile Leu Asn Pro Arg Ser Val Ala Gly Gly Phe Val Tyr Thr Tyr 
        915                 920                 925             


Lys Leu Val Asn Asn Gly Glu Lys Leu Glu Phe Leu His Lys Thr Pro 
    930                 935                 940                 


Val Glu Glu Val Pro Ala Ala Ile Ala Pro Phe Gln Gly Arg Val Leu 
945                 950                 955                 960 


Ile Gly Val Gly Lys Leu Leu Arg Val Tyr Asp Leu Gly Lys Lys Lys 
                965                 970                 975     


Leu Leu Arg Lys Cys Glu Asn Lys His Ile Ala Asn Tyr Ile Ser Gly 
            980                 985                 990         


Ile Gln Thr Ile Gly His Arg Val  Ile Val Ser Asp Val  Gln Glu Ser 
        995                 1000                 1005             


Phe Ile  Trp Val Arg Tyr Lys  Arg Asn Glu Asn Gln  Leu Ile Ile 
    1010                 1015                 1020             


Phe Ala  Asp Asp Thr Tyr Pro  Arg Trp Val Thr Thr  Ala Ser Leu 
    1025                 1030                 1035             


Leu Asp  Tyr Asp Thr Val Ala  Gly Ala Asp Lys Phe  Gly Asn Ile 
    1040                 1045                 1050             


Cys Val  Val Arg Leu Pro Pro  Asn Thr Asn Asp Glu  Val Asp Glu 
    1055                 1060                 1065             


Asp Pro  Thr Gly Asn Lys Ala  Leu Trp Asp Arg Gly  Leu Leu Asn 
    1070                 1075                 1080             


Gly Ala  Ser Gln Lys Ala Glu  Val Ile Met Asn Tyr  His Val Gly 
    1085                 1090                 1095             


Glu Thr  Val Leu Ser Leu Gln  Lys Thr Thr Leu Ile  Pro Gly Gly 
    1100                 1105                 1110             


Ser Glu  Ser Leu Val Tyr Thr  Thr Leu Ser Gly Gly  Ile Gly Ile 
    1115                 1120                 1125             


Leu Val  Pro Phe Thr Ser His  Glu Asp His Asp Phe  Phe Gln His 
    1130                 1135                 1140             


Val Glu  Met His Leu Arg Ser  Glu His Pro Pro Leu  Cys Gly Arg 
    1145                 1150                 1155             


Asp His  Leu Ser Phe Arg Ser  Tyr Tyr Phe Pro Val  Lys Asn Val 
    1160                 1165                 1170             


Ile Asp  Gly Asp Leu Cys Glu  Gln Phe Asn Ser Met  Glu Pro Asn 
    1175                 1180                 1185             


Lys Gln  Lys Asn Val Ser Glu  Glu Leu Asp Arg Thr  Pro Pro Glu 
    1190                 1195                 1200             


Val Ser  Lys Lys Leu Glu Asp  Ile Arg Thr Arg Tyr  Ala Phe 
    1205                 1210                 1215         


<210>  99
<211>  1093
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Gly Thr Gly Asp Phe Ile Cys Ile Ser Met Thr Gly Gly Ala Pro 
1               5                   10                  15      


Trp Gly Phe Arg Leu Gln Gly Gly Lys Glu Gln Lys Gln Pro Leu Gln 
            20                  25                  30          


Val Ala Lys Ile Arg Asn Gln Ser Lys Ala Ser Gly Ser Gly Leu Cys 
        35                  40                  45              


Glu Gly Asp Glu Val Val Ser Ile Asn Gly Asn Pro Cys Ala Asp Leu 
    50                  55                  60                  


Thr Tyr Pro Glu Val Ile Lys Leu Met Glu Ser Ile Thr Asp Ser Leu 
65                  70                  75                  80  


Gln Met Leu Ile Lys Arg Pro Ser Ser Gly Ile Ser Glu Ala Leu Ile 
                85                  90                  95      


Ser Glu Asn Glu Asn Lys Asn Leu Glu His Leu Thr His Gly Gly Tyr 
            100                 105                 110         


Val Glu Ser Thr Thr Leu Gln Ile Arg Pro Ala Thr Lys Thr Gln Cys 
        115                 120                 125             


Thr Glu Phe Phe Leu Ala Pro Val Lys Thr Glu Val Pro Leu Ala Glu 
    130                 135                 140                 


Asn Gln Arg Ser Gly Pro Asp Cys Ala Gly Ser Leu Lys Glu Glu Thr 
145                 150                 155                 160 


Gly Pro Ser Tyr Gln Arg Ala Pro Gln Met Pro Asp Ser Gln Arg Gly 
                165                 170                 175     


Arg Val Ala Glu Glu Leu Ile Leu Arg Glu Lys Val Glu Ala Val Gln 
            180                 185                 190         


Pro Gly Pro Val Val Glu Leu Gln Leu Ser Leu Ser Gln Glu Arg His 
        195                 200                 205             


Lys Gly Ala Ser Gly Pro Leu Val Ala Leu Pro Gly Ala Glu Lys Ser 
    210                 215                 220                 


Lys Ser Pro Asp Pro Asp Pro Asn Leu Ser His Asp Arg Ile Val His 
225                 230                 235                 240 


Ile Asn Ser Ile Pro Thr Asn Glu Lys Ala Asp Pro Phe Leu Arg Ser 
                245                 250                 255     


Ser Lys Ile Ile Gln Ile Ser Ser Gly Arg Glu Leu Arg Val Ile Gln 
            260                 265                 270         


Glu Ser Glu Ala Gly Asp Ala Gly Leu Pro Arg Val Glu Val Ile Leu 
        275                 280                 285             


Asp Cys Ser Asp Arg Gln Lys Thr Glu Gly Cys Arg Leu Gln Ala Gly 
    290                 295                 300                 


Lys Glu Cys Val Asp Ser Pro Val Glu Gly Gly Gln Ser Glu Ala Pro 
305                 310                 315                 320 


Pro Ser Leu Val Ser Phe Ala Val Ser Ser Glu Gly Thr Glu Gln Gly 
                325                 330                 335     


Glu Asp Pro Arg Ser Glu Lys Asp His Ser Arg Pro His Lys His Arg 
            340                 345                 350         


Ala Arg His Ala Arg Leu Arg Arg Ser Glu Ser Leu Ser Glu Lys Gln 
        355                 360                 365             


Val Lys Glu Ala Lys Ser Lys Cys Lys Ser Ile Ala Leu Leu Leu Thr 
    370                 375                 380                 


Asp Ala Pro Asn Pro Asn Ser Lys Gly Val Leu Met Phe Lys Lys Arg 
385                 390                 395                 400 


Arg Arg Arg Ala Arg Lys Tyr Thr Leu Val Ser Tyr Gly Thr Gly Glu 
                405                 410                 415     


Leu Glu Arg Glu Ala Asp Glu Glu Glu Glu Gly Asp Lys Glu Asp Thr 
            420                 425                 430         


Cys Glu Val Ala Phe Leu Gly Ala Ser Glu Ser Glu Val Asp Glu Glu 
        435                 440                 445             


Leu Leu Ser Asp Val Asp Asp Asn Thr Gln Val Val Asn Phe Asp Trp 
    450                 455                 460                 


Asp Ser Gly Leu Val Asp Ile Glu Lys Lys Leu Asn Arg Gly Asp Lys 
465                 470                 475                 480 


Met Glu Met Leu Pro Asp Thr Thr Gly Lys Gly Ala Leu Met Phe Ala 
                485                 490                 495     


Lys Arg Arg Glu Arg Met Asp Gln Ile Thr Ala Gln Lys Glu Glu Asp 
            500                 505                 510         


Lys Val Gly Gly Thr Pro Ser Arg Glu Gln Asp Ala Ala Gln Thr Asp 
        515                 520                 525             


Gly Leu Arg Thr Thr Thr Ser Tyr Gln Arg Lys Glu Glu Glu Ser Val 
    530                 535                 540                 


Arg Thr Gln Ser Ser Val Ser Lys Ser Tyr Ile Glu Val Ser His Gly 
545                 550                 555                 560 


Leu Gly His Val Pro Gln Gln Asn Gly Phe Ser Gly Thr Ser Glu Thr 
                565                 570                 575     


Ala Asn Ile Gln Arg Met Val Pro Met Asn Arg Thr Ala Lys Pro Phe 
            580                 585                 590         


Pro Gly Ser Val Asn Gln Pro Ala Thr Pro Phe Ser Pro Thr Arg Asn 
        595                 600                 605             


Met Thr Ser Pro Ile Ala Asp Phe Pro Ala Pro Pro Pro Tyr Ser Ala 
    610                 615                 620                 


Val Thr Pro Pro Pro Asp Ala Phe Ser Arg Gly Val Ser Ser Pro Ile 
625                 630                 635                 640 


Ala Gly Pro Ala Gln Pro Pro Pro Trp Pro Gln Pro Ala Pro Trp Ser 
                645                 650                 655     


Gln Pro Ala Phe Tyr Asp Ser Ser Glu Arg Ile Ala Ser Arg Asp Glu 
            660                 665                 670         


Arg Ile Ser Val Pro Ala Lys Arg Thr Gly Ile Leu Gln Glu Ala Lys 
        675                 680                 685             


Arg Arg Ser Thr Thr Lys Pro Met Phe Thr Phe Lys Glu Pro Lys Val 
    690                 695                 700                 


Ser Pro Asn Pro Glu Leu Leu Ser Leu Leu Gln Asn Ser Glu Gly Lys 
705                 710                 715                 720 


Arg Gly Thr Gly Ala Gly Gly Asp Ser Gly Pro Glu Glu Asp Tyr Leu 
                725                 730                 735     


Ser Leu Gly Ala Glu Ala Cys Asn Phe Met Gln Ser Ser Ser Ala Lys 
            740                 745                 750         


Gln Lys Thr Pro Pro Pro Val Ala Pro Lys Pro Ala Val Lys Ser Ser 
        755                 760                 765             


Ser Ser Gln Pro Val Thr Pro Val Ser Pro Val Trp Ser Pro Gly Val 
    770                 775                 780                 


Ala Pro Thr Gln Pro Pro Ala Phe Pro Thr Ser Asn Pro Ser Lys Gly 
785                 790                 795                 800 


Thr Val Val Ser Ser Ile Lys Ile Ala Gln Pro Ser Tyr Pro Pro Ala 
                805                 810                 815     


Arg Pro Ala Ser Thr Leu Asn Val Ala Gly Pro Phe Lys Gly Pro Gln 
            820                 825                 830         


Ala Ala Val Ala Ser Gln Asn Tyr Thr Pro Lys Pro Thr Val Ser Thr 
        835                 840                 845             


Pro Thr Val Asn Ala Val Gln Pro Gly Ala Val Gly Pro Ser Asn Glu 
    850                 855                 860                 


Leu Pro Gly Met Ser Gly Arg Gly Ala Gln Leu Phe Ala Lys Arg Gln 
865                 870                 875                 880 


Ser Arg Met Glu Lys Tyr Val Val Asp Ser Asp Thr Val Gln Ala His 
                885                 890                 895     


Ala Ala Arg Ala Gln Ser Pro Thr Pro Ser Leu Pro Ala Ser Trp Lys 
            900                 905                 910         


Tyr Ser Ser Asn Val Arg Ala Pro Pro Pro Val Ala Tyr Asn Pro Ile 
        915                 920                 925             


His Ser Pro Ser Tyr Pro Leu Ala Ala Leu Lys Ser Gln Pro Ser Ala 
    930                 935                 940                 


Ala Gln Pro Ser Lys Met Gly Lys Lys Lys Gly Lys Lys Pro Leu Asn 
945                 950                 955                 960 


Ala Leu Asp Val Met Lys His Gln Pro Tyr Gln Leu Asn Ala Ser Leu 
                965                 970                 975     


Phe Thr Phe Gln Pro Pro Asp Ala Lys Asp Gly Leu Pro Gln Lys Ser 
            980                 985                 990         


Ser Val Lys Val Asn Ser Ala Leu  Ala Met Lys Gln Ala  Leu Pro Pro 
        995                 1000                 1005             


Arg Pro  Val Asn Ala Ala Ser  Pro Thr Asn Val Gln  Ala Ser Ser 
    1010                 1015                 1020             


Val Tyr  Ser Val Pro Ala Tyr  Thr Ser Pro Pro Ser  Phe Phe Ala 
    1025                 1030                 1035             


Glu Ala  Ser Ser Pro Val Ser  Ala Ser Pro Val Pro  Val Gly Ile 
    1040                 1045                 1050             


Pro Thr  Ser Pro Lys Gln Glu  Ser Ala Ser Ser Ser  Tyr Phe Val 
    1055                 1060                 1065             


Ala Pro  Arg Pro Lys Phe Ser  Ala Lys Lys Ser Gly  Val Thr Ile 
    1070                 1075                 1080             


Gln Val  Trp Lys Pro Ser Val  Val Glu Glu 
    1085                 1090             


<210>  100
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Val Lys Gln Ile Glu Ser Lys Thr Ala Phe Gln Glu Ala Leu Asp 
1               5                   10                  15      


Ala Ala Gly Asp Lys Leu Val Val Val Asp Phe Ser Ala Thr Trp Cys 
            20                  25                  30          


Gly Pro Cys Lys Met Ile Lys Pro Phe Phe His Ser Leu Ser Glu Lys 
        35                  40                  45              


Tyr Ser Asn Val Ile Phe Leu Glu Val Asp Val Asp Asp Cys Gln Asp 
    50                  55                  60                  


Val Ala Ser Glu Cys Glu Val Lys Cys Met Pro Thr Phe Gln Phe Phe 
65                  70                  75                  80  


Lys Lys Gly Gln Lys Val Gly Glu Phe Ser Gly Ala Asn Lys Glu Lys 
                85                  90                  95      


Leu Glu Ala Thr Ile Asn Glu Leu Val 
            100                 105 


<210>  101
<211>  1170
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          


Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              


Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  


Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  


Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      


Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         


Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             


Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 


Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     


Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         


Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             


Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 


Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 


Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     


Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         


Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             


Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 


Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 


Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     


Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         


Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             


Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 


Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 
385                 390                 395                 400 


Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 
                405                 410                 415     


Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 
            420                 425                 430         


Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
        435                 440                 445             


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
    450                 455                 460                 


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
465                 470                 475                 480 


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 
                485                 490                 495     


Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 
            500                 505                 510         


Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 
        515                 520                 525             


Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 
    530                 535                 540                 


Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 
545                 550                 555                 560 


Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 
                565                 570                 575     


Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 
            580                 585                 590         


Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 
        595                 600                 605             


Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 
    610                 615                 620                 


Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 
625                 630                 635                 640 


Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 
                645                 650                 655     


Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 
            660                 665                 670         


Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 
        675                 680                 685             


Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 
    690                 695                 700                 


Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 
705                 710                 715                 720 


Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 
                725                 730                 735     


Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 
            740                 745                 750         


Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 
        755                 760                 765             


Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 
    770                 775                 780                 


Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 
785                 790                 795                 800 


Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 
                805                 810                 815     


Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 
            820                 825                 830         


Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 
        835                 840                 845             


Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 
    850                 855                 860                 


Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 
865                 870                 875                 880 


Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 
                885                 890                 895     


Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 
            900                 905                 910         


Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 
        915                 920                 925             


Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 
    930                 935                 940                 


Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 
945                 950                 955                 960 


Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 
                965                 970                 975     


Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 
            980                 985                 990         


Asp Pro Gly Leu Ala Val Gly Tyr  Asp Glu Phe Asn Ala  Val Asp Phe 
        995                 1000                 1005             


Ser Gly  Thr Phe Phe Ile Asn  Thr Glu Arg Asp Asp  Asp Tyr Ala 
    1010                 1015                 1020             


Gly Phe  Val Phe Gly Tyr Gln  Ser Ser Ser Arg Phe  Tyr Val Val 
    1025                 1030                 1035             


Met Trp  Lys Gln Val Thr Gln  Ser Tyr Trp Asp Thr  Asn Pro Thr 
    1040                 1045                 1050             


Arg Ala  Gln Gly Tyr Ser Gly  Leu Ser Val Lys Val  Val Asn Ser 
    1055                 1060                 1065             


Thr Thr  Gly Pro Gly Glu His  Leu Arg Asn Ala Leu  Trp His Thr 
    1070                 1075                 1080             


Gly Asn  Thr Pro Gly Gln Val  Arg Thr Leu Trp His  Asp Pro Arg 
    1085                 1090                 1095             


His Ile  Gly Trp Lys Asp Phe  Thr Ala Tyr Arg Trp  Arg Leu Ser 
    1100                 1105                 1110             


His Arg  Pro Lys Thr Gly Phe  Ile Arg Val Val Met  Tyr Glu Gly 
    1115                 1120                 1125             


Lys Lys  Ile Met Ala Asp Ser  Gly Pro Ile Tyr Asp  Lys Thr Tyr 
    1130                 1135                 1140             


Ala Gly  Gly Arg Leu Gly Leu  Phe Val Phe Ser Gln  Glu Met Val 
    1145                 1150                 1155             


Phe Phe  Ser Asp Leu Lys Tyr  Glu Cys Arg Asp Pro  
    1160                 1165                 1170 


<210>  102
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ala Ala Leu Met Thr Pro Gly Thr Gly Ala Pro Pro Ala Pro Gly 
1               5                   10                  15      


Asp Phe Ser Gly Glu Gly Ser Gln Gly Leu Pro Asp Pro Ser Pro Glu 
            20                  25                  30          


Pro Lys Gln Leu Pro Glu Leu Ile Arg Met Lys Arg Asp Gly Gly Arg 
        35                  40                  45              


Leu Ser Glu Ala Asp Ile Arg Gly Phe Val Ala Ala Val Val Asn Gly 
    50                  55                  60                  


Ser Ala Gln Gly Ala Gln Ile Gly Ala Met Leu Met Ala Ile Arg Leu 
65                  70                  75                  80  


Arg Gly Met Asp Leu Glu Glu Thr Ser Val Leu Thr Gln Ala Leu Ala 
                85                  90                  95      


Gln Ser Gly Gln Gln Leu Glu Trp Pro Glu Ala Trp Arg Gln Gln Leu 
            100                 105                 110         


Val Asp Lys His Ser Thr Gly Gly Val Gly Asp Lys Val Ser Leu Val 
        115                 120                 125             


Leu Ala Pro Ala Leu Ala Ala Cys Gly Cys Lys Val Pro Met Ile Ser 
    130                 135                 140                 


Gly Arg Gly Leu Gly His Thr Gly Gly Thr Leu Asp Lys Leu Glu Ser 
145                 150                 155                 160 


Ile Pro Gly Phe Asn Val Ile Gln Ser Pro Glu Gln Met Gln Val Leu 
                165                 170                 175     


Leu Asp Gln Ala Gly Cys Cys Ile Val Gly Gln Ser Glu Gln Leu Val 
            180                 185                 190         


Pro Ala Asp Gly Ile Leu Tyr Ala Ala Arg Asp Val Thr Ala Thr Val 
        195                 200                 205             


Asp Ser Leu Pro Leu Ile Thr Ala Ser Ile Leu Ser Lys Lys Leu Val 
    210                 215                 220                 


Glu Gly Leu Ser Ala Leu Val Val Asp Val Lys Phe Gly Gly Ala Ala 
225                 230                 235                 240 


Val Phe Pro Asn Gln Glu Gln Ala Arg Glu Leu Ala Lys Thr Leu Val 
                245                 250                 255     


Gly Val Gly Ala Ser Leu Gly Leu Arg Val Ala Ala Ala Leu Thr Ala 
            260                 265                 270         


Met Asp Lys Pro Leu Gly Arg Cys Val Gly His Ala Leu Glu Val Glu 
        275                 280                 285             


Glu Ala Leu Leu Cys Met Asp Gly Ala Gly Pro Pro Asp Leu Arg Asp 
    290                 295                 300                 


Leu Val Thr Thr Leu Gly Gly Ala Leu Leu Trp Leu Ser Gly His Ala 
305                 310                 315                 320 


Gly Thr Gln Ala Gln Gly Ala Ala Arg Val Ala Ala Ala Leu Asp Asp 
                325                 330                 335     


Gly Ser Ala Leu Gly Arg Phe Glu Arg Met Leu Ala Ala Gln Gly Val 
            340                 345                 350         


Asp Pro Gly Leu Ala Arg Ala Leu Cys Ser Gly Ser Pro Ala Glu Arg 
        355                 360                 365             


Arg Gln Leu Leu Pro Arg Ala Arg Glu Gln Glu Glu Leu Leu Ala Pro 
    370                 375                 380                 


Ala Asp Gly Thr Val Glu Leu Val Arg Ala Leu Pro Leu Ala Leu Val 
385                 390                 395                 400 


Leu His Glu Leu Gly Ala Gly Arg Ser Arg Ala Gly Glu Pro Leu Arg 
                405                 410                 415     


Leu Gly Val Gly Ala Glu Leu Leu Val Asp Val Gly Gln Arg Leu Arg 
            420                 425                 430         


Arg Gly Thr Pro Trp Leu Arg Val His Arg Asp Gly Pro Ala Leu Ser 
        435                 440                 445             


Gly Pro Gln Ser Arg Ala Leu Gln Glu Ala Leu Val Leu Ser Asp Arg 
    450                 455                 460                 


Ala Pro Phe Ala Ala Pro Ser Pro Phe Ala Glu Leu Val Leu Pro Pro 
465                 470                 475                 480 


Gln Gln 
        


<210>  103
<211>  34350
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Thr Thr Gln Ala Pro Thr Phe Thr Gln Pro Leu Gln Ser Val Val 
1               5                   10                  15      


Val Leu Glu Gly Ser Thr Ala Thr Phe Glu Ala His Ile Ser Gly Phe 
            20                  25                  30          


Pro Val Pro Glu Val Ser Trp Phe Arg Asp Gly Gln Val Ile Ser Thr 
        35                  40                  45              


Ser Thr Leu Pro Gly Val Gln Ile Ser Phe Ser Asp Gly Arg Ala Lys 
    50                  55                  60                  


Leu Thr Ile Pro Ala Val Thr Lys Ala Asn Ser Gly Arg Tyr Ser Leu 
65                  70                  75                  80  


Lys Ala Thr Asn Gly Ser Gly Gln Ala Thr Ser Thr Ala Glu Leu Leu 
                85                  90                  95      


Val Lys Ala Glu Thr Ala Pro Pro Asn Phe Val Gln Arg Leu Gln Ser 
            100                 105                 110         


Met Thr Val Arg Gln Gly Ser Gln Val Arg Leu Gln Val Arg Val Thr 
        115                 120                 125             


Gly Ile Pro Thr Pro Val Val Lys Phe Tyr Arg Asp Gly Ala Glu Ile 
    130                 135                 140                 


Gln Ser Ser Leu Asp Phe Gln Ile Ser Gln Glu Gly Asp Leu Tyr Ser 
145                 150                 155                 160 


Leu Leu Ile Ala Glu Ala Tyr Pro Glu Asp Ser Gly Thr Tyr Ser Val 
                165                 170                 175     


Asn Ala Thr Asn Ser Val Gly Arg Ala Thr Ser Thr Ala Glu Leu Leu 
            180                 185                 190         


Val Gln Gly Glu Glu Glu Val Pro Ala Lys Lys Thr Lys Thr Ile Val 
        195                 200                 205             


Ser Thr Ala Gln Ile Ser Glu Ser Arg Gln Thr Arg Ile Glu Lys Lys 
    210                 215                 220                 


Ile Glu Ala His Phe Asp Ala Arg Ser Ile Ala Thr Val Glu Met Val 
225                 230                 235                 240 


Ile Asp Gly Ala Ala Gly Gln Gln Leu Pro His Lys Thr Pro His Arg 
                245                 250                 255     


Ile Pro Pro Lys Pro Lys Ser Arg Ser Pro Thr Pro Pro Ser Ile Ala 
            260                 265                 270         


Ala Lys Ala Gln Leu Ala Arg Gln Gln Ser Pro Ser Pro Ile Arg His 
        275                 280                 285             


Ser Pro Ser Pro Val Arg His Val Arg Ala Pro Thr Pro Ser Pro Val 
    290                 295                 300                 


Arg Ser Val Ser Pro Ala Ala Arg Ile Ser Thr Ser Pro Ile Arg Ser 
305                 310                 315                 320 


Val Arg Ser Pro Leu Leu Met Arg Lys Thr Gln Ala Ser Thr Val Ala 
                325                 330                 335     


Thr Gly Pro Glu Val Pro Pro Pro Trp Lys Gln Glu Gly Tyr Val Ala 
            340                 345                 350         


Ser Ser Ser Glu Ala Glu Met Arg Glu Thr Thr Leu Thr Thr Ser Thr 
        355                 360                 365             


Gln Ile Arg Thr Glu Glu Arg Trp Glu Gly Arg Tyr Gly Val Gln Glu 
    370                 375                 380                 


Gln Val Thr Ile Ser Gly Ala Ala Gly Ala Ala Ala Ser Val Ser Ala 
385                 390                 395                 400 


Ser Ala Ser Tyr Ala Ala Glu Ala Val Ala Thr Gly Ala Lys Glu Val 
                405                 410                 415     


Lys Gln Asp Ala Asp Lys Ser Ala Ala Val Ala Thr Val Val Ala Ala 
            420                 425                 430         


Val Asp Met Ala Arg Val Arg Glu Pro Val Ile Ser Ala Val Glu Gln 
        435                 440                 445             


Thr Ala Gln Arg Thr Thr Thr Thr Ala Val His Ile Gln Pro Ala Gln 
    450                 455                 460                 


Glu Gln Val Arg Lys Glu Ala Glu Lys Thr Ala Val Thr Lys Val Val 
465                 470                 475                 480 


Val Ala Ala Asp Lys Ala Lys Glu Gln Glu Leu Lys Ser Arg Thr Lys 
                485                 490                 495     


Glu Val Ile Thr Thr Lys Gln Glu Gln Met His Val Thr His Glu Gln 
            500                 505                 510         


Ile Arg Lys Glu Thr Glu Lys Thr Phe Val Pro Lys Val Val Ile Ser 
        515                 520                 525             


Ala Ala Lys Ala Lys Glu Gln Glu Thr Arg Ile Ser Glu Glu Ile Thr 
    530                 535                 540                 


Lys Lys Gln Lys Gln Val Thr Gln Glu Ala Ile Arg Gln Glu Thr Glu 
545                 550                 555                 560 


Ile Thr Ala Ala Ser Met Val Val Val Ala Thr Ala Lys Ser Thr Lys 
                565                 570                 575     


Leu Glu Thr Val Pro Gly Ala Gln Glu Glu Thr Thr Thr Gln Gln Asp 
            580                 585                 590         


Gln Met His Leu Ser Tyr Glu Lys Ile Met Lys Glu Thr Arg Lys Thr 
        595                 600                 605             


Val Val Pro Lys Val Ile Val Ala Thr Pro Lys Val Lys Glu Gln Asp 
    610                 615                 620                 


Leu Val Ser Arg Gly Arg Glu Gly Ile Thr Thr Lys Arg Glu Gln Val 
625                 630                 635                 640 


Gln Ile Thr Gln Glu Lys Met Arg Lys Glu Ala Glu Lys Thr Ala Leu 
                645                 650                 655     


Ser Thr Ile Ala Val Ala Thr Ala Lys Ala Lys Glu Gln Glu Thr Ile 
            660                 665                 670         


Leu Arg Thr Arg Glu Thr Met Ala Thr Arg Gln Glu Gln Ile Gln Val 
        675                 680                 685             


Thr His Gly Lys Val Asp Val Gly Lys Lys Ala Glu Ala Val Ala Thr 
    690                 695                 700                 


Val Val Ala Ala Val Asp Gln Ala Arg Val Arg Glu Pro Arg Glu Pro 
705                 710                 715                 720 


Gly His Leu Glu Glu Ser Tyr Ala Gln Gln Thr Thr Leu Glu Tyr Gly 
                725                 730                 735     


Tyr Lys Glu Arg Ile Ser Ala Ala Lys Val Ala Glu Pro Pro Gln Arg 
            740                 745                 750         


Pro Ala Ser Glu Pro His Val Val Pro Lys Ala Val Lys Pro Arg Val 
        755                 760                 765             


Ile Gln Ala Pro Ser Glu Thr His Ile Lys Thr Thr Asp Gln Lys Gly 
    770                 775                 780                 


Met His Ile Ser Ser Gln Ile Lys Lys Thr Thr Asp Leu Thr Thr Glu 
785                 790                 795                 800 


Arg Leu Val His Val Asp Lys Arg Pro Arg Thr Ala Ser Pro His Phe 
                805                 810                 815     


Thr Val Ser Lys Ile Ser Val Pro Lys Thr Glu His Gly Tyr Glu Ala 
            820                 825                 830         


Ser Ile Ala Gly Ser Ala Ile Ala Thr Leu Gln Lys Glu Leu Ser Ala 
        835                 840                 845             


Thr Ser Ser Ala Gln Lys Ile Thr Lys Ser Val Lys Ala Pro Thr Val 
    850                 855                 860                 


Lys Pro Ser Glu Thr Arg Val Arg Ala Glu Pro Thr Pro Leu Pro Gln 
865                 870                 875                 880 


Phe Pro Phe Ala Asp Thr Pro Asp Thr Tyr Lys Ser Glu Ala Gly Val 
                885                 890                 895     


Glu Val Lys Lys Glu Val Gly Val Ser Ile Thr Gly Thr Thr Val Arg 
            900                 905                 910         


Glu Glu Arg Phe Glu Val Leu His Gly Arg Glu Ala Lys Val Thr Glu 
        915                 920                 925             


Thr Ala Arg Val Pro Ala Pro Val Glu Ile Pro Val Thr Pro Pro Thr 
    930                 935                 940                 


Leu Val Ser Gly Leu Lys Asn Val Thr Val Ile Glu Gly Glu Ser Val 
945                 950                 955                 960 


Thr Leu Glu Cys His Ile Ser Gly Tyr Pro Ser Pro Thr Val Thr Trp 
                965                 970                 975     


Tyr Arg Glu Asp Tyr Gln Ile Glu Ser Ser Ile Asp Phe Gln Ile Thr 
            980                 985                 990         


Phe Gln Ser Gly Ile Ala Arg Leu  Met Ile Arg Glu Ala  Phe Ala Glu 
        995                 1000                 1005             


Asp Ser  Gly Arg Phe Thr Cys  Ser Ala Val Asn Glu  Ala Gly Thr 
    1010                 1015                 1020             


Val Ser  Thr Ser Cys Tyr Leu  Ala Val Gln Val Ser  Glu Glu Phe 
    1025                 1030                 1035             


Glu Lys  Glu Thr Thr Ala Val  Thr Glu Lys Phe Thr  Thr Glu Glu 
    1040                 1045                 1050             


Lys Arg  Phe Val Glu Ser Arg  Asp Val Val Met Thr  Asp Thr Ser 
    1055                 1060                 1065             


Leu Thr  Glu Glu Gln Ala Gly  Pro Gly Glu Pro Ala  Ala Pro Tyr 
    1070                 1075                 1080             


Phe Ile  Thr Lys Pro Val Val  Gln Lys Leu Val Glu  Gly Gly Ser 
    1085                 1090                 1095             


Val Val  Phe Gly Cys Gln Val  Gly Gly Asn Pro Lys  Pro His Val 
    1100                 1105                 1110             


Tyr Trp  Lys Lys Ser Gly Val  Pro Leu Thr Thr Gly  Tyr Arg Tyr 
    1115                 1120                 1125             


Lys Val  Ser Tyr Asn Lys Gln  Thr Gly Glu Cys Lys  Leu Val Ile 
    1130                 1135                 1140             


Ser Met  Thr Phe Ala Asp Asp  Ala Gly Glu Tyr Thr  Ile Val Val 
    1145                 1150                 1155             


Arg Asn  Lys His Gly Glu Thr  Ser Ala Ser Ala Ser  Leu Leu Glu 
    1160                 1165                 1170             


Glu Ala  Asp Tyr Glu Leu Leu  Met Lys Ser Gln Gln  Glu Met Leu 
    1175                 1180                 1185             


Tyr Gln  Thr Gln Val Thr Ala  Phe Val Gln Glu Pro  Lys Val Gly 
    1190                 1195                 1200             


Glu Thr  Ala Pro Gly Phe Val  Tyr Ser Glu Tyr Glu  Lys Glu Tyr 
    1205                 1210                 1215             


Glu Lys  Glu Gln Ala Leu Ile  Arg Lys Lys Met Ala  Lys Asp Thr 
    1220                 1225                 1230             


Val Val  Val Arg Thr Tyr Val  Glu Asp Gln Glu Phe  His Ile Ser 
    1235                 1240                 1245             


Ser Phe  Glu Glu Arg Leu Ile  Lys Glu Ile Glu Tyr  Arg Ile Ile 
    1250                 1255                 1260             


Lys Thr  Thr Leu Glu Glu Leu  Leu Glu Glu Asp Gly  Glu Glu Lys 
    1265                 1270                 1275             


Met Ala  Val Asp Ile Ser Glu  Ser Glu Ala Val Glu  Ser Gly Phe 
    1280                 1285                 1290             


Asp Leu  Arg Ile Lys Asn Tyr  Arg Ile Leu Glu Gly  Met Gly Val 
    1295                 1300                 1305             


Thr Phe  His Cys Lys Met Ser  Gly Tyr Pro Leu Pro  Lys Ile Ala 
    1310                 1315                 1320             


Trp Tyr  Lys Asp Gly Lys Arg  Ile Lys His Gly Glu  Arg Tyr Gln 
    1325                 1330                 1335             


Met Asp  Phe Leu Gln Asp Gly  Arg Ala Ser Leu Arg  Ile Pro Val 
    1340                 1345                 1350             


Val Leu  Pro Glu Asp Glu Gly  Ile Tyr Thr Ala Phe  Ala Ser Asn 
    1355                 1360                 1365             


Ile Lys  Gly Asn Ala Ile Cys  Ser Gly Lys Leu Tyr  Val Glu Pro 
    1370                 1375                 1380             


Ala Ala  Pro Leu Gly Ala Pro  Thr Tyr Ile Pro Thr  Leu Glu Pro 
    1385                 1390                 1395             


Val Ser  Arg Ile Arg Ser Leu  Ser Pro Arg Ser Val  Ser Arg Ser 
    1400                 1405                 1410             


Pro Ile  Arg Met Ser Pro Ala  Arg Met Ser Pro Ala  Arg Met Ser 
    1415                 1420                 1425             


Pro Ala  Arg Met Ser Pro Ala  Arg Met Ser Pro Gly  Arg Arg Leu 
    1430                 1435                 1440             


Glu Glu  Thr Asp Glu Ser Gln  Leu Glu Arg Leu Tyr  Lys Pro Val 
    1445                 1450                 1455             


Phe Val  Leu Lys Pro Val Ser  Phe Lys Cys Leu Glu  Gly Gln Thr 
    1460                 1465                 1470             


Ala Arg  Phe Asp Leu Lys Val  Val Gly Arg Pro Met  Pro Glu Thr 
    1475                 1480                 1485             


Phe Trp  Phe His Asp Gly Gln  Gln Ile Val Asn Asp  Tyr Thr His 
    1490                 1495                 1500             


Lys Val  Val Ile Lys Glu Asp  Gly Thr Gln Ser Leu  Ile Ile Val 
    1505                 1510                 1515             


Pro Ala  Thr Pro Ser Asp Ser  Gly Glu Trp Thr Val  Val Ala Gln 
    1520                 1525                 1530             


Asn Arg  Ala Gly Arg Ser Ser  Ile Ser Val Ile Leu  Thr Val Glu 
    1535                 1540                 1545             


Ala Val  Glu His Gln Val Lys  Pro Met Phe Val Glu  Lys Leu Lys 
    1550                 1555                 1560             


Asn Val  Asn Ile Lys Glu Gly  Ser Gln Leu Glu Met  Lys Val Arg 
    1565                 1570                 1575             


Ala Thr  Gly Asn Pro Asn Pro  Asp Ile Val Trp Leu  Lys Asn Ser 
    1580                 1585                 1590             


Asp Ile  Ile Val Pro His Lys  Tyr Pro Lys Ile Arg  Ile Glu Gly 
    1595                 1600                 1605             


Thr Lys  Gly Glu Ala Ala Leu  Lys Ile Asp Ser Thr  Val Ser Gln 
    1610                 1615                 1620             


Asp Ser  Ala Trp Tyr Thr Ala  Thr Ala Ile Asn Lys  Ala Gly Arg 
    1625                 1630                 1635             


Asp Thr  Thr Arg Cys Lys Val  Asn Val Glu Val Glu  Phe Ala Glu 
    1640                 1645                 1650             


Pro Glu  Pro Glu Arg Lys Leu  Ile Ile Pro Arg Gly  Thr Tyr Arg 
    1655                 1660                 1665             


Ala Lys  Glu Ile Ala Ala Pro  Glu Leu Glu Pro Leu  His Leu Arg 
    1670                 1675                 1680             


Tyr Gly  Gln Glu Gln Trp Glu  Glu Gly Asp Leu Tyr  Asp Lys Glu 
    1685                 1690                 1695             


Lys Gln  Gln Lys Pro Phe Phe  Lys Lys Lys Leu Thr  Ser Leu Arg 
    1700                 1705                 1710             


Leu Lys  Arg Phe Gly Pro Ala  His Phe Glu Cys Arg  Leu Thr Pro 
    1715                 1720                 1725             


Ile Gly  Asp Pro Thr Met Val  Val Glu Trp Leu His  Asp Gly Lys 
    1730                 1735                 1740             


Pro Leu  Glu Ala Ala Asn Arg  Leu Arg Met Ile Asn  Glu Phe Gly 
    1745                 1750                 1755             


Tyr Cys  Ser Leu Asp Tyr Gly  Val Ala Tyr Ser Arg  Asp Ser Gly 
    1760                 1765                 1770             


Ile Ile  Thr Cys Arg Ala Thr  Asn Lys Tyr Gly Thr  Asp His Thr 
    1775                 1780                 1785             


Ser Ala  Thr Leu Ile Val Lys  Asp Glu Lys Ser Leu  Val Glu Glu 
    1790                 1795                 1800             


Ser Gln  Leu Pro Glu Gly Arg  Lys Gly Leu Gln Arg  Ile Glu Glu 
    1805                 1810                 1815             


Leu Glu  Arg Met Ala His Glu  Gly Ala Leu Thr Gly  Val Thr Thr 
    1820                 1825                 1830             


Asp Gln  Lys Glu Lys Gln Lys  Pro Asp Ile Val Leu  Tyr Pro Glu 
    1835                 1840                 1845             


Pro Val  Arg Val Leu Glu Gly  Glu Thr Ala Arg Phe  Arg Cys Arg 
    1850                 1855                 1860             


Val Thr  Gly Tyr Pro Gln Pro  Lys Val Asn Trp Tyr  Leu Asn Gly 
    1865                 1870                 1875             


Gln Leu  Ile Arg Lys Ser Lys  Arg Phe Arg Val Arg  Tyr Asp Gly 
    1880                 1885                 1890             


Ile His  Tyr Leu Asp Ile Val  Asp Cys Lys Ser Tyr  Asp Thr Gly 
    1895                 1900                 1905             


Glu Val  Lys Val Thr Ala Glu  Asn Pro Glu Gly Val  Ile Glu His 
    1910                 1915                 1920             


Lys Val  Lys Leu Glu Ile Gln  Gln Arg Glu Asp Phe  Arg Ser Val 
    1925                 1930                 1935             


Leu Arg  Arg Ala Pro Glu Pro  Arg Pro Glu Phe His  Val His Glu 
    1940                 1945                 1950             


Pro Gly  Lys Leu Gln Phe Glu  Val Gln Lys Val Asp  Arg Pro Val 
    1955                 1960                 1965             


Asp Thr  Thr Glu Thr Lys Glu  Val Val Lys Leu Lys  Arg Ala Glu 
    1970                 1975                 1980             


Arg Ile  Thr His Glu Lys Val  Pro Glu Glu Ser Glu  Glu Leu Arg 
    1985                 1990                 1995             


Ser Lys  Phe Lys Arg Arg Thr  Glu Glu Gly Tyr Tyr  Glu Ala Ile 
    2000                 2005                 2010             


Thr Ala  Val Glu Leu Lys Ser  Arg Lys Lys Asp Glu  Ser Tyr Glu 
    2015                 2020                 2025             


Glu Leu  Leu Arg Lys Thr Lys  Asp Glu Leu Leu His  Trp Thr Lys 
    2030                 2035                 2040             


Glu Leu  Thr Glu Glu Glu Lys  Lys Ala Leu Ala Glu  Glu Gly Lys 
    2045                 2050                 2055             


Ile Thr  Ile Pro Thr Phe Lys  Pro Asp Lys Ile Glu  Leu Ser Pro 
    2060                 2065                 2070             


Ser Met  Glu Ala Pro Lys Ile  Phe Glu Arg Ile Gln  Ser Gln Thr 
    2075                 2080                 2085             


Val Gly  Gln Gly Ser Asp Ala  His Phe Arg Val Arg  Val Val Gly 
    2090                 2095                 2100             


Lys Pro  Asp Pro Glu Cys Glu  Trp Tyr Lys Asn Gly  Val Lys Ile 
    2105                 2110                 2115             


Glu Arg  Ser Asp Arg Ile Tyr  Trp Tyr Trp Pro Glu  Asp Asn Val 
    2120                 2125                 2130             


Cys Glu  Leu Val Ile Arg Asp  Val Thr Ala Glu Asp  Ser Ala Ser 
    2135                 2140                 2145             


Ile Met  Val Lys Ala Ile Asn  Ile Ala Gly Glu Thr  Ser Ser His 
    2150                 2155                 2160             


Ala Phe  Leu Leu Val Gln Ala  Lys Gln Leu Ile Thr  Phe Thr Gln 
    2165                 2170                 2175             


Glu Leu  Gln Asp Val Val Ala  Lys Glu Lys Asp Thr  Met Ala Thr 
    2180                 2185                 2190             


Phe Glu  Cys Glu Thr Ser Glu  Pro Phe Val Lys Val  Lys Trp Tyr 
    2195                 2200                 2205             


Lys Asp  Gly Met Glu Val His  Glu Gly Asp Lys Tyr  Arg Met His 
    2210                 2215                 2220             


Ser Asp  Arg Lys Val His Phe  Leu Ser Ile Leu Thr  Ile Asp Thr 
    2225                 2230                 2235             


Ser Asp  Ala Glu Asp Tyr Ser  Cys Val Leu Val Glu  Asp Glu Asn 
    2240                 2245                 2250             


Val Lys  Thr Thr Ala Lys Leu  Ile Val Glu Gly Ala  Val Val Glu 
    2255                 2260                 2265             


Phe Val  Lys Glu Leu Gln Asp  Ile Glu Val Pro Glu  Ser Tyr Ser 
    2270                 2275                 2280             


Gly Glu  Leu Glu Cys Ile Val  Ser Pro Glu Asn Ile  Glu Gly Lys 
    2285                 2290                 2295             


Trp Tyr  His Asn Asp Val Glu  Leu Lys Ser Asn Gly  Lys Tyr Thr 
    2300                 2305                 2310             


Ile Thr  Ser Arg Arg Gly Arg  Gln Asn Leu Thr Val  Lys Asp Val 
    2315                 2320                 2325             


Thr Lys  Glu Asp Gln Gly Glu  Tyr Ser Phe Val Ile  Asp Gly Lys 
    2330                 2335                 2340             


Lys Thr  Thr Cys Lys Leu Lys  Met Lys Pro Arg Pro  Ile Ala Ile 
    2345                 2350                 2355             


Leu Gln  Gly Leu Ser Asp Gln  Lys Val Cys Glu Gly  Asp Ile Val 
    2360                 2365                 2370             


Gln Leu  Glu Val Lys Val Ser  Leu Glu Ser Val Glu  Gly Val Trp 
    2375                 2380                 2385             


Met Lys  Asp Gly Gln Glu Val  Gln Pro Ser Asp Arg  Val His Ile 
    2390                 2395                 2400             


Val Ile  Asp Lys Gln Ser His  Met Leu Leu Ile Glu  Asp Met Thr 
    2405                 2410                 2415             


Lys Glu  Asp Ala Gly Asn Tyr  Ser Phe Thr Ile Pro  Ala Leu Gly 
    2420                 2425                 2430             


Leu Ser  Thr Ser Gly Arg Val  Ser Val Tyr Ser Val  Asp Val Ile 
    2435                 2440                 2445             


Thr Pro  Leu Lys Asp Val Asn  Val Ile Glu Gly Thr  Lys Ala Val 
    2450                 2455                 2460             


Leu Glu  Cys Lys Val Ser Val  Pro Asp Val Thr Ser  Val Lys Trp 
    2465                 2470                 2475             


Tyr Leu  Asn Asp Glu Gln Ile  Lys Pro Asp Asp Arg  Val Gln Ala 
    2480                 2485                 2490             


Ile Val  Lys Gly Thr Lys Gln  Arg Leu Val Ile Asn  Arg Thr His 
    2495                 2500                 2505             


Ala Ser  Asp Glu Gly Pro Tyr  Lys Leu Ile Val Gly  Arg Val Glu 
    2510                 2515                 2520             


Thr Asn  Cys Asn Leu Ser Val  Glu Lys Ile Lys Ile  Ile Arg Gly 
    2525                 2530                 2535             


Leu Arg  Asp Leu Thr Cys Thr  Glu Thr Gln Asn Val  Val Phe Glu 
    2540                 2545                 2550             


Val Glu  Leu Ser His Ser Gly  Ile Asp Val Leu Trp  Asn Phe Lys 
    2555                 2560                 2565             


Asp Lys  Glu Ile Lys Pro Ser  Ser Lys Tyr Lys Ile  Glu Ala His 
    2570                 2575                 2580             


Gly Lys  Ile Tyr Lys Leu Thr  Val Leu Asn Met Met  Lys Asp Asp 
    2585                 2590                 2595             


Glu Gly  Lys Tyr Thr Phe Tyr  Ala Gly Glu Asn Ile  Thr Ser Gly 
    2600                 2605                 2610             


Lys Leu  Thr Val Ala Gly Gly  Ala Ile Ser Lys Pro  Leu Thr Asp 
    2615                 2620                 2625             


Gln Thr  Val Ala Glu Ser Gln  Glu Ala Val Phe Glu  Cys Glu Val 
    2630                 2635                 2640             


Ala Asn  Pro Asp Ser Lys Gly  Glu Trp Leu Arg Asp  Gly Lys His 
    2645                 2650                 2655             


Leu Pro  Leu Thr Asn Asn Ile  Arg Ser Glu Ser Asp  Gly His Lys 
    2660                 2665                 2670             


Arg Arg  Leu Ile Ile Ala Ala  Thr Lys Leu Asp Asp  Ile Gly Glu 
    2675                 2680                 2685             


Tyr Thr  Tyr Lys Val Ala Thr  Ser Lys Thr Ser Ala  Lys Leu Lys 
    2690                 2695                 2700             


Val Glu  Ala Val Lys Ile Lys  Lys Thr Leu Lys Asn  Leu Thr Val 
    2705                 2710                 2715             


Thr Glu  Thr Gln Asp Ala Val  Phe Thr Val Glu Leu  Thr His Pro 
    2720                 2725                 2730             


Asn Val  Lys Gly Val Gln Trp  Ile Lys Asn Gly Val  Val Leu Glu 
    2735                 2740                 2745             


Ser Asn  Glu Lys Tyr Ala Ile  Ser Val Lys Gly Thr  Ile Tyr Ser 
    2750                 2755                 2760             


Leu Arg  Ile Lys Asn Cys Ala  Ile Val Asp Glu Ser  Val Tyr Gly 
    2765                 2770                 2775             


Phe Arg  Leu Gly Arg Leu Gly  Ala Ser Ala Arg Leu  His Val Glu 
    2780                 2785                 2790             


Thr Val  Lys Ile Ile Lys Lys  Pro Lys Asp Val Thr  Ala Leu Glu 
    2795                 2800                 2805             


Asn Ala  Thr Val Ala Phe Glu  Val Ser Val Ser His  Asp Thr Val 
    2810                 2815                 2820             


Pro Val  Lys Trp Phe His Lys  Asn Val Glu Ile Lys  Pro Ser Asp 
    2825                 2830                 2835             


Lys His  Arg Leu Val Ser Glu  Arg Lys Val His Lys  Leu Met Leu 
    2840                 2845                 2850             


Gln Asn  Ile Ser Pro Ser Asp  Ala Gly Glu Tyr Thr  Ala Val Val 
    2855                 2860                 2865             


Gly Gln  Leu Glu Cys Lys Ala  Lys Leu Phe Val Glu  Thr Leu His 
    2870                 2875                 2880             


Ile Thr  Lys Thr Met Lys Asn  Ile Glu Val Pro Glu  Thr Lys Thr 
    2885                 2890                 2895             


Ala Ser  Phe Glu Cys Glu Val  Ser His Phe Asn Val  Pro Ser Met 
    2900                 2905                 2910             


Trp Leu  Lys Asn Gly Val Glu  Ile Glu Met Ser Glu  Lys Phe Lys 
    2915                 2920                 2925             


Ile Val  Val Gln Gly Lys Leu  His Gln Leu Ile Ile  Met Asn Thr 
    2930                 2935                 2940             


Ser Thr  Glu Asp Ser Ala Glu  Tyr Thr Phe Val Cys  Gly Asn Asp 
    2945                 2950                 2955             


Gln Val  Ser Ala Thr Leu Thr  Val Thr Pro Ile Met  Ile Thr Ser 
    2960                 2965                 2970             


Met Leu  Lys Asp Ile Asn Ala  Glu Glu Lys Asp Thr  Ile Thr Phe 
    2975                 2980                 2985             


Glu Val  Thr Val Asn Tyr Glu  Gly Ile Ser Tyr Lys  Trp Leu Lys 
    2990                 2995                 3000             


Asn Gly  Val Glu Ile Lys Ser  Thr Asp Lys Cys Gln  Met Arg Thr 
    3005                 3010                 3015             


Lys Lys  Leu Thr His Ser Leu  Asn Ile Arg Asn Val  His Phe Gly 
    3020                 3025                 3030             


Asp Ala  Ala Asp Tyr Thr Phe  Val Ala Gly Lys Ala  Thr Ser Thr 
    3035                 3040                 3045             


Ala Thr  Leu Tyr Val Glu Ala  Arg His Ile Glu Phe  Arg Lys His 
    3050                 3055                 3060             


Ile Lys  Asp Ile Lys Val Leu  Glu Lys Lys Arg Ala  Met Phe Glu 
    3065                 3070                 3075             


Cys Glu  Val Ser Glu Pro Asp  Ile Thr Val Gln Trp  Met Lys Asp 
    3080                 3085                 3090             


Asp Gln  Glu Leu Gln Ile Thr  Asp Arg Ile Lys Ile  Gln Lys Glu 
    3095                 3100                 3105             


Lys Tyr  Val His Arg Leu Leu  Ile Pro Ser Thr Arg  Met Ser Asp 
    3110                 3115                 3120             


Ala Gly  Lys Tyr Thr Val Val  Ala Gly Gly Asn Val  Ser Thr Ala 
    3125                 3130                 3135             


Lys Leu  Phe Val Glu Gly Arg  Asp Val Arg Ile Arg  Ser Ile Lys 
    3140                 3145                 3150             


Lys Glu  Val Gln Val Ile Glu  Lys Gln Arg Ala Val  Val Glu Phe 
    3155                 3160                 3165             


Glu Val  Asn Glu Asp Asp Val  Asp Ala His Trp Tyr  Lys Asp Gly 
    3170                 3175                 3180             


Ile Glu  Ile Asn Phe Gln Val  Gln Glu Arg His Lys  Tyr Val Val 
    3185                 3190                 3195             


Glu Arg  Arg Ile His Arg Met  Phe Ile Ser Glu Thr  Arg Gln Ser 
    3200                 3205                 3210             


Asp Ala  Gly Glu Tyr Thr Phe  Val Ala Gly Arg Asn  Arg Ser Ser 
    3215                 3220                 3225             


Val Thr  Leu Tyr Val Asn Ala  Pro Glu Pro Pro Gln  Val Leu Gln 
    3230                 3235                 3240             


Glu Leu  Gln Pro Val Thr Val  Gln Ser Gly Lys Pro  Ala Arg Phe 
    3245                 3250                 3255             


Cys Ala  Val Ile Ser Gly Arg  Pro Gln Pro Lys Ile  Ser Trp Tyr 
    3260                 3265                 3270             


Lys Glu  Glu Gln Leu Leu Ser  Thr Gly Phe Lys Cys  Lys Phe Leu 
    3275                 3280                 3285             


His Asp  Gly Gln Glu Tyr Thr  Leu Leu Leu Ile Glu  Ala Phe Pro 
    3290                 3295                 3300             


Glu Asp  Ala Ala Val Tyr Thr  Cys Glu Ala Lys Asn  Asp Tyr Gly 
    3305                 3310                 3315             


Val Ala  Thr Thr Ser Ala Ser  Leu Ser Val Glu Val  Pro Glu Val 
    3320                 3325                 3330             


Val Ser  Pro Asp Gln Glu Met  Pro Val Tyr Pro Pro  Ala Ile Ile 
    3335                 3340                 3345             


Thr Pro  Leu Gln Asp Thr Val  Thr Ser Glu Gly Gln  Pro Ala Arg 
    3350                 3355                 3360             


Phe Gln  Cys Arg Val Ser Gly  Thr Asp Leu Lys Val  Ser Trp Tyr 
    3365                 3370                 3375             


Ser Lys  Asp Lys Lys Ile Lys  Pro Ser Arg Phe Phe  Arg Met Thr 
    3380                 3385                 3390             


Gln Phe  Glu Asp Thr Tyr Gln  Leu Glu Ile Ala Glu  Ala Tyr Pro 
    3395                 3400                 3405             


Glu Asp  Glu Gly Thr Tyr Thr  Phe Val Ala Ser Asn  Ala Val Gly 
    3410                 3415                 3420             


Gln Val  Ser Ser Thr Ala Asn  Leu Ser Leu Glu Ala  Pro Glu Ser 
    3425                 3430                 3435             


Ile Leu  His Glu Arg Ile Glu  Gln Glu Ile Glu Met  Glu Met Lys 
    3440                 3445                 3450             


Glu Phe  Ser Ser Ser Phe Leu  Ser Ala Glu Glu Glu  Gly Leu His 
    3455                 3460                 3465             


Ser Ala  Glu Leu Gln Leu Ser  Lys Ile Asn Glu Thr  Leu Glu Leu 
    3470                 3475                 3480             


Leu Ser  Glu Ser Pro Val Tyr  Ser Thr Lys Phe Asp  Ser Glu Lys 
    3485                 3490                 3495             


Glu Gly  Thr Gly Pro Ile Phe  Ile Lys Glu Val Ser  Asn Ala Asp 
    3500                 3505                 3510             


Ile Ser  Met Gly Asp Val Ala  Thr Leu Ser Val Thr  Val Ile Gly 
    3515                 3520                 3525             


Ile Pro  Lys Pro Lys Ile Gln  Trp Phe Phe Asn Gly  Val Leu Leu 
    3530                 3535                 3540             


Thr Pro  Ser Ala Asp Tyr Lys  Phe Val Phe Asp Gly  Asp Asp His 
    3545                 3550                 3555             


Ser Leu  Ile Ile Leu Phe Thr  Lys Leu Glu Asp Glu  Gly Glu Tyr 
    3560                 3565                 3570             


Thr Cys  Met Ala Ser Asn Asp  Tyr Gly Lys Thr Ile  Cys Ser Ala 
    3575                 3580                 3585             


Tyr Leu  Lys Ile Asn Ser Lys  Gly Glu Gly His Lys  Asp Thr Glu 
    3590                 3595                 3600             


Thr Glu  Ser Ala Val Ala Lys  Ser Leu Glu Lys Leu  Gly Gly Pro 
    3605                 3610                 3615             


Cys Pro  Pro His Phe Leu Lys  Glu Leu Lys Pro Ile  Arg Cys Ala 
    3620                 3625                 3630             


Gln Gly  Leu Pro Ala Ile Phe  Glu Tyr Thr Val Val  Gly Glu Pro 
    3635                 3640                 3645             


Ala Pro  Thr Val Thr Trp Phe  Lys Glu Asn Lys Gln  Leu Cys Thr 
    3650                 3655                 3660             


Ser Val  Tyr Tyr Thr Ile Ile  His Asn Pro Asn Gly  Ser Gly Thr 
    3665                 3670                 3675             


Phe Ile  Val Asn Asp Pro Gln  Arg Glu Asp Ser Gly  Leu Tyr Ile 
    3680                 3685                 3690             


Cys Lys  Ala Glu Asn Met Leu  Gly Glu Ser Thr Cys  Ala Ala Glu 
    3695                 3700                 3705             


Leu Leu  Val Leu Leu Glu Asp  Thr Asp Met Thr Asp  Thr Pro Cys 
    3710                 3715                 3720             


Lys Ala  Lys Ser Thr Pro Glu  Ala Pro Glu Asp Phe  Pro Gln Thr 
    3725                 3730                 3735             


Pro Leu  Lys Gly Pro Ala Val  Glu Ala Leu Asp Ser  Glu Gln Glu 
    3740                 3745                 3750             


Ile Ala  Thr Phe Val Lys Asp  Thr Ile Leu Lys Ala  Ala Leu Ile 
    3755                 3760                 3765             


Thr Glu  Glu Asn Gln Gln Leu  Ser Tyr Glu His Ile  Ala Lys Ala 
    3770                 3775                 3780             


Asn Glu  Leu Ser Ser Gln Leu  Pro Leu Gly Ala Gln  Glu Leu Gln 
    3785                 3790                 3795             


Ser Ile  Leu Glu Gln Asp Lys  Leu Thr Pro Glu Ser  Thr Arg Glu 
    3800                 3805                 3810             


Phe Leu  Cys Ile Asn Gly Ser  Ile His Phe Gln Pro  Leu Lys Glu 
    3815                 3820                 3825             


Pro Ser  Pro Asn Leu Gln Leu  Gln Ile Val Gln Ser  Gln Lys Thr 
    3830                 3835                 3840             


Phe Ser  Lys Glu Gly Ile Leu  Met Pro Glu Glu Pro  Glu Thr Gln 
    3845                 3850                 3855             


Ala Val  Leu Ser Asp Thr Glu  Lys Ile Phe Pro Ser  Ala Met Ser 
    3860                 3865                 3870             


Ile Glu  Gln Ile Asn Ser Leu  Thr Val Glu Pro Leu  Lys Thr Leu 
    3875                 3880                 3885             


Leu Ala  Glu Pro Glu Gly Asn  Tyr Pro Gln Ser Ser  Ile Glu Pro 
    3890                 3895                 3900             


Pro Met  His Ser Tyr Leu Thr  Ser Val Ala Glu Glu  Val Leu Ser 
    3905                 3910                 3915             


Pro Lys  Glu Lys Thr Val Ser  Asp Thr Asn Arg Glu  Gln Arg Val 
    3920                 3925                 3930             


Thr Leu  Gln Lys Gln Glu Ala  Gln Ser Ala Leu Ile  Leu Ser Gln 
    3935                 3940                 3945             


Ser Leu  Ala Glu Gly His Val  Glu Ser Leu Gln Ser  Pro Asp Val 
    3950                 3955                 3960             


Met Ile  Ser Gln Val Asn Tyr  Glu Pro Leu Val Pro  Ser Glu His 
    3965                 3970                 3975             


Ser Cys  Thr Glu Gly Gly Lys  Ile Leu Ile Glu Ser  Ala Asn Pro 
    3980                 3985                 3990             


Leu Glu  Asn Ala Gly Gln Asp  Ser Ala Val Arg Ile  Glu Glu Gly 
    3995                 4000                 4005             


Lys Ser  Leu Arg Phe Pro Leu  Ala Leu Glu Glu Lys  Gln Val Leu 
    4010                 4015                 4020             


Leu Lys  Glu Glu His Ser Asp  Asn Val Val Met Pro  Pro Asp Gln 
    4025                 4030                 4035             


Ile Ile  Glu Ser Lys Arg Glu  Pro Val Ala Ile Lys  Lys Val Gln 
    4040                 4045                 4050             


Glu Val  Gln Gly Arg Asp Leu  Leu Ser Lys Glu Ser  Leu Leu Ser 
    4055                 4060                 4065             


Gly Ile  Pro Glu Glu Gln Arg  Leu Asn Leu Lys Ile  Gln Ile Cys 
    4070                 4075                 4080             


Arg Ala  Leu Gln Ala Ala Val  Ala Ser Glu Gln Pro  Gly Leu Phe 
    4085                 4090                 4095             


Ser Glu  Trp Leu Arg Asn Ile  Glu Lys Val Glu Val  Glu Ala Val 
    4100                 4105                 4110             


Asn Ile  Thr Gln Glu Pro Arg  His Ile Met Cys Met  Tyr Leu Val 
    4115                 4120                 4125             


Thr Ser  Ala Lys Ser Val Thr  Glu Glu Val Thr Ile  Ile Ile Glu 
    4130                 4135                 4140             


Asp Val  Asp Pro Gln Met Ala  Asn Leu Lys Met Glu  Leu Arg Asp 
    4145                 4150                 4155             


Ala Leu  Cys Ala Ile Ile Tyr  Glu Glu Ile Asp Ile  Leu Thr Ala 
    4160                 4165                 4170             


Glu Gly  Pro Arg Ile Gln Gln  Gly Ala Lys Thr Ser  Leu Gln Glu 
    4175                 4180                 4185             


Glu Met  Asp Ser Phe Ser Gly  Ser Gln Lys Val Glu  Pro Ile Thr 
    4190                 4195                 4200             


Glu Pro  Glu Val Glu Ser Lys  Tyr Leu Ile Ser Thr  Glu Glu Val 
    4205                 4210                 4215             


Ser Tyr  Phe Asn Val Gln Ser  Arg Val Lys Tyr Leu  Asp Ala Thr 
    4220                 4225                 4230             


Pro Val  Thr Lys Gly Val Ala  Ser Ala Val Val Ser  Asp Glu Lys 
    4235                 4240                 4245             


Gln Asp  Glu Ser Leu Lys Pro  Ser Glu Glu Lys Glu  Glu Ser Ser 
    4250                 4255                 4260             


Ser Glu  Ser Gly Thr Glu Glu  Val Ala Thr Val Lys  Ile Gln Glu 
    4265                 4270                 4275             


Ala Glu  Gly Gly Leu Ile Lys  Glu Asp Gly Pro Met  Ile His Thr 
    4280                 4285                 4290             


Pro Leu  Val Asp Thr Val Ser  Glu Glu Gly Asp Ile  Val His Leu 
    4295                 4300                 4305             


Thr Thr  Ser Ile Thr Asn Ala  Lys Glu Val Asn Trp  Tyr Phe Glu 
    4310                 4315                 4320             


Asn Lys  Leu Val Pro Ser Asp  Glu Lys Phe Lys Cys  Leu Gln Asp 
    4325                 4330                 4335             


Gln Asn  Thr Tyr Thr Leu Val  Ile Asp Lys Val Asn  Thr Glu Asp 
    4340                 4345                 4350             


His Gln  Gly Glu Tyr Val Cys  Glu Ala Leu Asn Asp  Ser Gly Lys 
    4355                 4360                 4365             


Thr Ala  Thr Ser Ala Lys Leu  Thr Val Val Lys Arg  Ala Ala Pro 
    4370                 4375                 4380             


Val Ile  Lys Arg Lys Ile Glu  Pro Leu Glu Val Ala  Leu Gly His 
    4385                 4390                 4395             


Leu Ala  Lys Phe Thr Cys Glu  Ile Gln Ser Ala Pro  Asn Val Arg 
    4400                 4405                 4410             


Phe Gln  Trp Phe Lys Ala Gly  Arg Glu Ile Tyr Glu  Ser Asp Lys 
    4415                 4420                 4425             


Cys Ser  Ile Arg Ser Ser Lys  Tyr Ile Ser Ser Leu  Glu Ile Leu 
    4430                 4435                 4440             


Arg Thr  Gln Val Val Asp Cys  Gly Glu Tyr Thr Cys  Lys Ala Ser 
    4445                 4450                 4455             


Asn Glu  Tyr Gly Ser Val Ser  Cys Thr Ala Thr Leu  Thr Val Thr 
    4460                 4465                 4470             


Glu Ala  Tyr Pro Pro Thr Phe  Leu Ser Arg Pro Lys  Ser Leu Thr 
    4475                 4480                 4485             


Thr Phe  Val Gly Lys Ala Ala  Lys Phe Ile Cys Thr  Val Thr Gly 
    4490                 4495                 4500             


Thr Pro  Val Ile Glu Thr Ile  Trp Gln Lys Asp Gly  Ala Ala Leu 
    4505                 4510                 4515             


Ser Pro  Ser Pro Asn Trp Lys  Ile Ser Asp Ala Glu  Asn Lys His 
    4520                 4525                 4530             


Ile Leu  Glu Leu Ser Asn Leu  Thr Ile Gln Asp Arg  Gly Val Tyr 
    4535                 4540                 4545             


Ser Cys  Lys Ala Ser Asn Lys  Phe Gly Ala Asp Ile  Cys Gln Ala 
    4550                 4555                 4560             


Glu Leu  Ile Ile Ile Asp Lys  Pro His Phe Ile Lys  Glu Leu Glu 
    4565                 4570                 4575             


Pro Val  Gln Ser Ala Ile Asn  Lys Lys Val His Leu  Glu Cys Gln 
    4580                 4585                 4590             


Val Asp  Glu Asp Arg Lys Val  Thr Val Thr Trp Ser  Lys Asp Gly 
    4595                 4600                 4605             


Gln Lys  Leu Pro Pro Gly Lys  Asp Tyr Lys Ile Cys  Phe Glu Asp 
    4610                 4615                 4620             


Lys Ile  Ala Thr Leu Glu Ile  Pro Leu Ala Lys Leu  Lys Asp Ser 
    4625                 4630                 4635             


Gly Thr  Tyr Val Cys Thr Ala  Ser Asn Glu Ala Gly  Ser Ser Ser 
    4640                 4645                 4650             


Cys Ser  Ala Thr Val Thr Val  Arg Glu Pro Pro Ser  Phe Val Lys 
    4655                 4660                 4665             


Lys Val  Asp Pro Ser Tyr Leu  Met Leu Pro Gly Glu  Ser Ala Arg 
    4670                 4675                 4680             


Leu His  Cys Lys Leu Lys Gly  Ser Pro Val Ile Gln  Val Thr Trp 
    4685                 4690                 4695             


Phe Lys  Asn Asn Lys Glu Leu  Ser Glu Ser Asn Thr  Val Arg Met 
    4700                 4705                 4710             


Tyr Phe  Val Asn Ser Glu Ala  Ile Leu Asp Ile Thr  Asp Val Lys 
    4715                 4720                 4725             


Val Glu  Asp Ser Gly Ser Tyr  Ser Cys Glu Ala Val  Asn Asp Val 
    4730                 4735                 4740             


Gly Ser  Asp Ser Cys Ser Thr  Glu Ile Val Ile Lys  Glu Pro Pro 
    4745                 4750                 4755             


Ser Phe  Ile Lys Thr Leu Glu  Pro Ala Asp Ile Val  Arg Gly Thr 
    4760                 4765                 4770             


Asn Ala  Leu Leu Gln Cys Glu  Val Ser Gly Thr Gly  Pro Phe Glu 
    4775                 4780                 4785             


Ile Ser  Trp Phe Lys Asp Lys  Lys Gln Ile Arg Ser  Ser Lys Lys 
    4790                 4795                 4800             


Tyr Arg  Leu Phe Ser Gln Lys  Ser Leu Val Cys Leu  Glu Ile Phe 
    4805                 4810                 4815             


Ser Phe  Asn Ser Ala Asp Val  Gly Glu Tyr Glu Cys  Val Val Ala 
    4820                 4825                 4830             


Asn Glu  Val Gly Lys Cys Gly  Cys Met Ala Thr His  Leu Leu Lys 
    4835                 4840                 4845             


Glu Pro  Pro Thr Phe Val Lys  Lys Val Asp Asp Leu  Ile Ala Leu 
    4850                 4855                 4860             


Gly Gly  Gln Thr Val Thr Leu  Gln Ala Ala Val Arg  Gly Ser Glu 
    4865                 4870                 4875             


Pro Ile  Ser Val Thr Trp Met  Lys Gly Gln Glu Val  Ile Arg Glu 
    4880                 4885                 4890             


Asp Gly  Lys Ile Lys Met Ser  Phe Ser Asn Gly Val  Ala Val Leu 
    4895                 4900                 4905             


Ile Ile  Pro Asp Val Gln Ile  Ser Phe Gly Gly Lys  Tyr Thr Cys 
    4910                 4915                 4920             


Leu Ala  Glu Asn Glu Ala Gly  Ser Gln Thr Ser Val  Gly Glu Leu 
    4925                 4930                 4935             


Ile Val  Lys Glu Pro Ala Lys  Ile Ile Glu Arg Ala  Glu Leu Ile 
    4940                 4945                 4950             


Gln Val  Thr Ala Gly Asp Pro  Ala Thr Leu Glu Tyr  Thr Val Ala 
    4955                 4960                 4965             


Gly Thr  Pro Glu Leu Lys Pro  Lys Trp Tyr Lys Asp  Gly Arg Pro 
    4970                 4975                 4980             


Leu Val  Ala Ser Lys Lys Tyr  Arg Ile Ser Phe Lys  Asn Asn Val 
    4985                 4990                 4995             


Ala Gln  Leu Lys Phe Tyr Ser  Ala Glu Leu His Asp  Ser Gly Gln 
    5000                 5005                 5010             


Tyr Thr  Phe Glu Ile Ser Asn  Glu Val Gly Ser Ser  Ser Cys Glu 
    5015                 5020                 5025             


Thr Thr  Phe Thr Val Leu Asp  Arg Asp Ile Ala Pro  Phe Phe Thr 
    5030                 5035                 5040             


Lys Pro  Leu Arg Asn Val Asp  Ser Val Val Asn Gly  Thr Cys Arg 
    5045                 5050                 5055             


Leu Asp  Cys Lys Ile Ala Gly  Ser Leu Pro Met Arg  Val Ser Trp 
    5060                 5065                 5070             


Phe Lys  Asp Gly Lys Glu Ile  Ala Ala Ser Asp Arg  Tyr Arg Ile 
    5075                 5080                 5085             


Ala Phe  Val Glu Gly Thr Ala  Ser Leu Glu Ile Ile  Arg Val Asp 
    5090                 5095                 5100             


Met Asn  Asp Ala Gly Asn Phe  Thr Cys Arg Ala Thr  Asn Ser Val 
    5105                 5110                 5115             


Gly Ser  Lys Asp Ser Ser Gly  Ala Leu Ile Val Gln  Glu Pro Pro 
    5120                 5125                 5130             


Ser Phe  Val Thr Lys Pro Gly  Ser Lys Asp Val Leu  Pro Gly Ser 
    5135                 5140                 5145             


Ala Val  Cys Leu Lys Ser Thr  Phe Gln Gly Ser Thr  Pro Leu Thr 
    5150                 5155                 5160             


Ile Arg  Trp Phe Lys Gly Asn  Lys Glu Leu Val Ser  Gly Gly Ser 
    5165                 5170                 5175             


Cys Tyr  Ile Thr Lys Glu Ala  Leu Glu Ser Ser Leu  Glu Leu Tyr 
    5180                 5185                 5190             


Leu Val  Lys Thr Ser Asp Ser  Gly Thr Tyr Thr Cys  Lys Val Ser 
    5195                 5200                 5205             


Asn Val  Ala Gly Gly Val Glu  Cys Ser Ala Asn Leu  Phe Val Lys 
    5210                 5215                 5220             


Glu Pro  Ala Thr Phe Val Glu  Lys Leu Glu Pro Ser  Gln Leu Leu 
    5225                 5230                 5235             


Lys Lys  Gly Asp Ala Thr Gln  Leu Ala Cys Lys Val  Thr Gly Thr 
    5240                 5245                 5250             


Pro Pro  Ile Lys Ile Thr Trp  Phe Ala Asn Asp Arg  Glu Ile Lys 
    5255                 5260                 5265             


Glu Ser  Ser Lys His Arg Met  Ser Phe Val Glu Ser  Thr Ala Val 
    5270                 5275                 5280             


Leu Arg  Leu Thr Asp Val Gly  Ile Glu Asp Ser Gly  Glu Tyr Met 
    5285                 5290                 5295             


Cys Glu  Ala Gln Asn Glu Ala  Gly Ser Asp His Cys  Ser Ser Ile 
    5300                 5305                 5310             


Val Ile  Val Lys Glu Ser Pro  Tyr Phe Thr Lys Glu  Phe Lys Pro 
    5315                 5320                 5325             


Ile Glu  Val Leu Lys Glu Tyr  Asp Val Met Leu Leu  Ala Glu Val 
    5330                 5335                 5340             


Ala Gly  Thr Pro Pro Phe Glu  Ile Thr Trp Phe Lys  Asp Asn Thr 
    5345                 5350                 5355             


Ile Leu  Arg Ser Gly Arg Lys  Tyr Lys Thr Phe Ile  Gln Asp His 
    5360                 5365                 5370             


Leu Val  Ser Leu Gln Ile Leu  Lys Phe Val Ala Ala  Asp Ala Gly 
    5375                 5380                 5385             


Glu Tyr  Gln Cys Arg Val Thr  Asn Glu Val Gly Ser  Ser Ile Cys 
    5390                 5395                 5400             


Ser Ala  Arg Val Thr Leu Arg  Glu Pro Pro Ser Phe  Ile Lys Lys 
    5405                 5410                 5415             


Ile Glu  Ser Thr Ser Ser Leu  Arg Gly Gly Thr Ala  Ala Phe Gln 
    5420                 5425                 5430             


Ala Thr  Leu Lys Gly Ser Leu  Pro Ile Thr Val Thr  Trp Leu Lys 
    5435                 5440                 5445             


Asp Ser  Asp Glu Ile Thr Glu  Asp Asp Asn Ile Arg  Met Thr Phe 
    5450                 5455                 5460             


Glu Asn  Asn Val Ala Ser Leu  Tyr Leu Ser Gly Ile  Glu Val Lys 
    5465                 5470                 5475             


His Asp  Gly Lys Tyr Val Cys  Gln Ala Lys Asn Asp  Ala Gly Ile 
    5480                 5485                 5490             


Gln Arg  Cys Ser Ala Leu Leu  Ser Val Lys Glu Pro  Ala Thr Ile 
    5495                 5500                 5505             


Thr Glu  Glu Ala Val Ser Ile  Asp Val Thr Gln Gly  Asp Pro Ala 
    5510                 5515                 5520             


Thr Leu  Gln Val Lys Phe Ser  Gly Thr Lys Glu Ile  Thr Ala Lys 
    5525                 5530                 5535             


Trp Phe  Lys Asp Gly Gln Glu  Leu Thr Leu Gly Ser  Lys Tyr Lys 
    5540                 5545                 5550             


Ile Ser  Val Thr Asp Thr Val  Ser Ile Leu Lys Ile  Ile Ser Thr 
    5555                 5560                 5565             


Glu Lys  Lys Asp Ser Gly Glu  Tyr Thr Phe Glu Val  Gln Asn Asp 
    5570                 5575                 5580             


Val Gly  Arg Ser Ser Cys Lys  Ala Arg Ile Asn Val  Leu Asp Leu 
    5585                 5590                 5595             


Ile Ile  Pro Pro Ser Phe Thr  Lys Lys Leu Lys Lys  Met Asp Ser 
    5600                 5605                 5610             


Ile Lys  Gly Ser Phe Ile Asp  Leu Glu Cys Ile Val  Ala Gly Ser 
    5615                 5620                 5625             


His Pro  Ile Ser Ile Gln Trp  Phe Lys Asp Asp Gln  Glu Ile Ser 
    5630                 5635                 5640             


Ala Ser  Glu Lys Tyr Lys Phe  Ser Phe His Asp Asn  Thr Ala Phe 
    5645                 5650                 5655             


Leu Glu  Ile Ser Gln Leu Glu  Gly Thr Asp Ser Gly  Thr Tyr Thr 
    5660                 5665                 5670             


Cys Ser  Ala Thr Asn Lys Ala  Gly His Asn Gln Cys  Ser Gly His 
    5675                 5680                 5685             


Leu Thr  Val Lys Glu Pro Pro  Tyr Phe Val Glu Lys  Pro Gln Ser 
    5690                 5695                 5700             


Gln Asp  Val Asn Pro Asn Thr  Arg Val Gln Leu Lys  Ala Leu Val 
    5705                 5710                 5715             


Gly Gly  Thr Ala Pro Met Thr  Ile Lys Trp Phe Lys  Asp Asn Lys 
    5720                 5725                 5730             


Glu Leu  His Ser Gly Ala Ala  Arg Ser Val Trp Lys  Asp Asp Thr 
    5735                 5740                 5745             


Ser Thr  Ser Leu Glu Leu Phe  Ala Ala Lys Ala Thr  Asp Ser Gly 
    5750                 5755                 5760             


Thr Tyr  Ile Cys Gln Leu Ser  Asn Asp Val Gly Thr  Ala Thr Ser 
    5765                 5770                 5775             


Lys Ala  Thr Leu Phe Val Lys  Glu Pro Pro Gln Phe  Ile Lys Lys 
    5780                 5785                 5790             


Pro Ser  Pro Val Leu Val Leu  Arg Asn Gly Gln Ser  Thr Thr Phe 
    5795                 5800                 5805             


Glu Cys  Gln Ile Thr Gly Thr  Pro Lys Ile Arg Val  Ser Trp Tyr 
    5810                 5815                 5820             


Leu Asp  Gly Asn Glu Ile Thr  Ala Ile Gln Lys His  Gly Ile Ser 
    5825                 5830                 5835             


Phe Ile  Asp Gly Leu Ala Thr  Phe Gln Ile Ser Gly  Ala Arg Val 
    5840                 5845                 5850             


Glu Asn  Ser Gly Thr Tyr Val  Cys Glu Ala Arg Asn  Asp Ala Gly 
    5855                 5860                 5865             


Thr Ala  Ser Cys Ser Ile Glu  Leu Lys Val Lys Glu  Pro Pro Thr 
    5870                 5875                 5880             


Phe Ile  Arg Glu Leu Lys Pro  Val Glu Val Val Lys  Tyr Ser Asp 
    5885                 5890                 5895             


Val Glu  Leu Glu Cys Glu Val  Thr Gly Thr Pro Pro  Phe Glu Val 
    5900                 5905                 5910             


Thr Trp  Leu Lys Asn Asn Arg  Glu Ile Arg Ser Ser  Lys Lys Tyr 
    5915                 5920                 5925             


Thr Leu  Thr Asp Arg Val Ser  Val Phe Asn Leu His  Ile Thr Lys 
    5930                 5935                 5940             


Cys Asp  Pro Ser Asp Thr Gly  Glu Tyr Gln Cys Ile  Val Ser Asn 
    5945                 5950                 5955             


Glu Gly  Gly Ser Cys Ser Cys  Ser Thr Arg Val Ala  Leu Lys Glu 
    5960                 5965                 5970             


Pro Pro  Ser Phe Ile Lys Lys  Ile Glu Asn Thr Thr  Thr Val Leu 
    5975                 5980                 5985             


Lys Ser  Ser Ala Thr Phe Gln  Ser Thr Val Ala Gly  Ser Pro Pro 
    5990                 5995                 6000             


Ile Ser  Ile Thr Trp Leu Lys  Asp Asp Gln Ile Leu  Asp Glu Asp 
    6005                 6010                 6015             


Asp Asn  Val Tyr Ile Ser Phe  Val Asp Ser Val Ala  Thr Leu Gln 
    6020                 6025                 6030             


Ile Arg  Ser Val Asp Asn Gly  His Ser Gly Arg Tyr  Thr Cys Gln 
    6035                 6040                 6045             


Ala Lys  Asn Glu Ser Gly Val  Glu Arg Cys Tyr Ala  Phe Leu Leu 
    6050                 6055                 6060             


Val Gln  Glu Pro Ala Gln Ile  Val Glu Lys Ala Lys  Ser Val Asp 
    6065                 6070                 6075             


Val Thr  Glu Lys Asp Pro Met  Thr Leu Glu Cys Val  Val Ala Gly 
    6080                 6085                 6090             


Thr Pro  Glu Leu Lys Val Lys  Trp Leu Lys Asp Gly  Lys Gln Ile 
    6095                 6100                 6105             


Val Pro  Ser Arg Tyr Phe Ser  Met Ser Phe Glu Asn  Asn Val Ala 
    6110                 6115                 6120             


Ser Phe  Arg Ile Gln Ser Val  Met Lys Gln Asp Ser  Gly Gln Tyr 
    6125                 6130                 6135             


Thr Phe  Lys Val Glu Asn Asp  Phe Gly Ser Ser Ser  Cys Asp Ala 
    6140                 6145                 6150             


Tyr Leu  Arg Val Leu Asp Gln  Asn Ile Pro Pro Ser  Phe Thr Lys 
    6155                 6160                 6165             


Lys Leu  Thr Lys Met Asp Lys  Val Leu Gly Ser Ser  Ile His Met 
    6170                 6175                 6180             


Glu Cys  Lys Val Ser Gly Ser  Leu Pro Ile Ser Ala  Gln Trp Phe 
    6185                 6190                 6195             


Lys Asp  Gly Lys Glu Ile Ser  Thr Ser Ala Lys Tyr  Arg Leu Val 
    6200                 6205                 6210             


Cys His  Glu Arg Ser Val Ser  Leu Glu Val Asn Asn  Leu Glu Leu 
    6215                 6220                 6225             


Glu Asp  Thr Ala Asn Tyr Thr  Cys Lys Val Ser Asn  Val Ala Gly 
    6230                 6235                 6240             


Asp Asp  Ala Cys Ser Gly Ile  Leu Thr Val Lys Glu  Pro Pro Ser 
    6245                 6250                 6255             


Phe Leu  Val Lys Pro Gly Arg  Gln Gln Ala Ile Pro  Asp Ser Thr 
    6260                 6265                 6270             


Val Glu  Phe Lys Ala Ile Leu  Lys Gly Thr Pro Pro  Phe Lys Ile 
    6275                 6280                 6285             


Lys Trp  Phe Lys Asp Asp Val  Glu Leu Val Ser Gly  Pro Lys Cys 
    6290                 6295                 6300             


Phe Ile  Gly Leu Glu Gly Ser  Thr Ser Phe Leu Asn  Leu Tyr Ser 
    6305                 6310                 6315             


Val Asp  Ala Ser Lys Thr Gly  Gln Tyr Thr Cys His  Val Thr Asn 
    6320                 6325                 6330             


Asp Val  Gly Ser Asp Ser Cys  Thr Thr Met Leu Leu  Val Thr Glu 
    6335                 6340                 6345             


Pro Pro  Lys Phe Val Lys Lys  Leu Glu Ala Ser Lys  Ile Val Lys 
    6350                 6355                 6360             


Ala Gly  Asp Ser Ser Arg Leu  Glu Cys Lys Ile Ala  Gly Ser Pro 
    6365                 6370                 6375             


Glu Ile  Arg Val Val Trp Phe  Arg Asn Glu His Glu  Leu Pro Ala 
    6380                 6385                 6390             


Ser Asp  Lys Tyr Arg Met Thr  Phe Ile Asp Ser Val  Ala Val Ile 
    6395                 6400                 6405             


Gln Met  Asn Asn Leu Ser Thr  Glu Asp Ser Gly Asp  Phe Ile Cys 
    6410                 6415                 6420             


Glu Ala  Gln Asn Pro Ala Gly  Ser Thr Ser Cys Ser  Thr Lys Val 
    6425                 6430                 6435             


Ile Val  Lys Glu Pro Pro Val  Phe Ser Ser Phe Pro  Pro Ile Val 
    6440                 6445                 6450             


Glu Thr  Leu Lys Asn Ala Glu  Val Ser Leu Glu Cys  Glu Leu Ser 
    6455                 6460                 6465             


Gly Thr  Pro Pro Phe Glu Val  Val Trp Tyr Lys Asp  Lys Arg Gln 
    6470                 6475                 6480             


Leu Arg  Ser Ser Lys Lys Tyr  Lys Ile Ala Ser Lys  Asn Phe His 
    6485                 6490                 6495             


Thr Ser  Ile His Ile Leu Asn  Val Asp Thr Ser Asp  Ile Gly Glu 
    6500                 6505                 6510             


Tyr His  Cys Lys Ala Gln Asn  Glu Val Gly Ser Asp  Thr Cys Val 
    6515                 6520                 6525             


Cys Thr  Val Lys Leu Lys Glu  Pro Pro Arg Phe Val  Ser Lys Leu 
    6530                 6535                 6540             


Asn Ser  Leu Thr Val Val Ala  Gly Glu Pro Ala Glu  Leu Gln Ala 
    6545                 6550                 6555             


Ser Ile  Glu Gly Ala Gln Pro  Ile Phe Val Gln Trp  Leu Lys Glu 
    6560                 6565                 6570             


Lys Glu  Glu Val Ile Arg Glu  Ser Glu Asn Ile Arg  Ile Thr Phe 
    6575                 6580                 6585             


Val Glu  Asn Val Ala Thr Leu  Gln Phe Ala Lys Ala  Glu Pro Ala 
    6590                 6595                 6600             


Asn Ala  Gly Lys Tyr Ile Cys  Gln Ile Lys Asn Asp  Gly Gly Met 
    6605                 6610                 6615             


Glu Glu  Asn Met Ala Thr Leu  Met Val Leu Glu Pro  Ala Val Ile 
    6620                 6625                 6630             


Val Glu  Lys Ala Gly Pro Met  Thr Val Thr Val Gly  Glu Thr Cys 
    6635                 6640                 6645             


Thr Leu  Glu Cys Lys Val Ala  Gly Thr Pro Glu Leu  Ser Val Glu 
    6650                 6655                 6660             


Trp Tyr  Lys Asp Gly Lys Leu  Leu Thr Ser Ser Gln  Lys His Lys 
    6665                 6670                 6675             


Phe Ser  Phe Tyr Asn Lys Ile  Ser Ser Leu Arg Ile  Leu Ser Val 
    6680                 6685                 6690             


Glu Arg  Gln Asp Ala Gly Thr  Tyr Thr Phe Gln Val  Gln Asn Asn 
    6695                 6700                 6705             


Val Gly  Lys Ser Ser Cys Thr  Ala Val Val Asp Val  Ser Asp Arg 
    6710                 6715                 6720             


Ala Val  Pro Pro Ser Phe Thr  Arg Arg Leu Lys Asn  Thr Gly Gly 
    6725                 6730                 6735             


Val Leu  Gly Ala Ser Cys Ile  Leu Glu Cys Lys Val  Ala Gly Ser 
    6740                 6745                 6750             


Ser Pro  Ile Ser Val Ala Trp  Phe His Glu Lys Thr  Lys Ile Val 
    6755                 6760                 6765             


Ser Gly  Ala Lys Tyr Gln Thr  Thr Phe Ser Asp Asn  Val Cys Thr 
    6770                 6775                 6780             


Leu Gln  Leu Asn Ser Leu Asp  Ser Ser Asp Met Gly  Asn Tyr Thr 
    6785                 6790                 6795             


Cys Val  Ala Ala Asn Val Ala  Gly Ser Asp Glu Cys  Arg Ala Val 
    6800                 6805                 6810             


Leu Thr  Val Gln Glu Pro Pro  Ser Phe Val Lys Glu  Pro Glu Pro 
    6815                 6820                 6825             


Leu Glu  Val Leu Pro Gly Lys  Asn Val Thr Phe Thr  Ser Val Ile 
    6830                 6835                 6840             


Arg Gly  Thr Pro Pro Phe Lys  Val Asn Trp Phe Arg  Gly Ala Arg 
    6845                 6850                 6855             


Glu Leu  Val Lys Gly Asp Arg  Cys Asn Ile Tyr Phe  Glu Asp Thr 
    6860                 6865                 6870             


Val Ala  Glu Leu Glu Leu Phe  Asn Ile Asp Ile Ser  Gln Ser Gly 
    6875                 6880                 6885             


Glu Tyr  Thr Cys Val Val Ser  Asn Asn Ala Gly Gln  Ala Ser Cys 
    6890                 6895                 6900             


Thr Thr  Arg Leu Phe Val Lys  Glu Pro Ala Ala Phe  Leu Lys Arg 
    6905                 6910                 6915             


Leu Ser  Asp His Ser Val Glu  Pro Gly Lys Ser Ile  Ile Leu Glu 
    6920                 6925                 6930             


Ser Thr  Tyr Thr Gly Thr Leu  Pro Ile Ser Val Thr  Trp Lys Lys 
    6935                 6940                 6945             


Asp Gly  Phe Asn Ile Thr Thr  Ser Glu Lys Cys Asn  Ile Val Thr 
    6950                 6955                 6960             


Thr Glu  Lys Thr Cys Ile Leu  Glu Ile Leu Asn Ser  Thr Lys Arg 
    6965                 6970                 6975             


Asp Ala  Gly Gln Tyr Ser Cys  Glu Ile Glu Asn Glu  Ala Gly Arg 
    6980                 6985                 6990             


Asp Val  Cys Gly Ala Leu Val  Ser Thr Leu Glu Pro  Pro Tyr Phe 
    6995                 7000                 7005             


Val Thr  Glu Leu Glu Pro Leu  Glu Ala Ala Val Gly  Asp Ser Val 
    7010                 7015                 7020             


Ser Leu  Gln Cys Gln Val Ala  Gly Thr Pro Glu Ile  Thr Val Ser 
    7025                 7030                 7035             


Trp Tyr  Lys Gly Asp Thr Lys  Leu Arg Pro Thr Pro  Glu Tyr Arg 
    7040                 7045                 7050             


Thr Tyr  Phe Thr Asn Asn Val  Ala Thr Leu Val Phe  Asn Lys Val 
    7055                 7060                 7065             


Asn Ile  Asn Asp Ser Gly Glu  Tyr Thr Cys Lys Ala  Glu Asn Ser 
    7070                 7075                 7080             


Ile Gly  Thr Ala Ser Ser Lys  Thr Val Phe Arg Ile  Gln Glu Arg 
    7085                 7090                 7095             


Gln Leu  Pro Pro Ser Phe Ala  Arg Gln Leu Lys Asp  Ile Glu Gln 
    7100                 7105                 7110             


Thr Val  Gly Leu Pro Val Thr  Leu Thr Cys Arg Leu  Asn Gly Ser 
    7115                 7120                 7125             


Ala Pro  Ile Gln Val Cys Trp  Tyr Arg Asp Gly Val  Leu Leu Arg 
    7130                 7135                 7140             


Asp Asp  Glu Asn Leu Gln Thr  Ser Phe Val Asp Asn  Val Ala Thr 
    7145                 7150                 7155             


Leu Lys  Ile Leu Gln Thr Asp  Leu Ser His Ser Gly  Gln Tyr Ser 
    7160                 7165                 7170             


Cys Ser  Ala Ser Asn Pro Leu  Gly Thr Ala Ser Ser  Ser Ala Arg 
    7175                 7180                 7185             


Leu Thr  Ala Arg Glu Pro Lys  Lys Ser Pro Phe Phe  Asp Ile Lys 
    7190                 7195                 7200             


Pro Val  Ser Ile Asp Val Ile  Ala Gly Glu Ser Ala  Asp Phe Glu 
    7205                 7210                 7215             


Cys His  Val Thr Gly Ala Gln  Pro Met Arg Ile Thr  Trp Ser Lys 
    7220                 7225                 7230             


Asp Asn  Lys Glu Ile Arg Pro  Gly Gly Asn Tyr Thr  Ile Thr Cys 
    7235                 7240                 7245             


Val Gly  Asn Thr Pro His Leu  Arg Ile Leu Lys Val  Gly Lys Gly 
    7250                 7255                 7260             


Asp Ser  Gly Gln Tyr Thr Cys  Gln Ala Thr Asn Asp  Val Gly Lys 
    7265                 7270                 7275             


Asp Met  Cys Ser Ala Gln Leu  Ser Val Lys Glu Pro  Pro Lys Phe 
    7280                 7285                 7290             


Val Lys  Lys Leu Glu Ala Ser  Lys Val Ala Lys Gln  Gly Glu Ser 
    7295                 7300                 7305             


Ile Gln  Leu Glu Cys Lys Ile  Ser Gly Ser Pro Glu  Ile Lys Val 
    7310                 7315                 7320             


Ser Trp  Phe Arg Asn Asp Ser  Glu Leu His Glu Ser  Trp Lys Tyr 
    7325                 7330                 7335             


Asn Met  Ser Phe Ile Asn Ser  Val Ala Leu Leu Thr  Ile Asn Glu 
    7340                 7345                 7350             


Ala Ser  Ala Glu Asp Ser Gly  Asp Tyr Ile Cys Glu  Ala His Asn 
    7355                 7360                 7365             


Gly Val  Gly Asp Ala Ser Cys  Ser Thr Ala Leu Thr  Val Lys Ala 
    7370                 7375                 7380             


Pro Pro  Val Phe Thr Gln Lys  Pro Ser Pro Val Gly  Ala Leu Lys 
    7385                 7390                 7395             


Gly Ser  Asp Val Ile Leu Gln  Cys Glu Ile Ser Gly  Thr Pro Pro 
    7400                 7405                 7410             


Phe Glu  Val Val Trp Val Lys  Asp Arg Lys Gln Val  Arg Asn Ser 
    7415                 7420                 7425             


Lys Lys  Phe Lys Ile Thr Ser  Lys His Phe Asp Thr  Ser Leu His 
    7430                 7435                 7440             


Ile Leu  Asn Leu Glu Ala Ser  Asp Val Gly Glu Tyr  His Cys Lys 
    7445                 7450                 7455             


Ala Thr  Asn Glu Val Gly Ser  Asp Thr Cys Ser Cys  Ser Val Lys 
    7460                 7465                 7470             


Phe Lys  Glu Pro Pro Arg Phe  Val Lys Lys Leu Ser  Asp Thr Ser 
    7475                 7480                 7485             


Thr Leu  Ile Gly Asp Ala Val  Glu Leu Arg Ala Ile  Val Glu Gly 
    7490                 7495                 7500             


Phe Gln  Pro Ile Ser Val Val  Trp Leu Lys Asp Arg  Gly Glu Val 
    7505                 7510                 7515             


Ile Arg  Glu Ser Glu Asn Thr  Arg Ile Ser Phe Ile  Asp Asn Ile 
    7520                 7525                 7530             


Ala Thr  Leu Gln Leu Gly Ser  Pro Glu Ala Ser Asn  Ser Gly Lys 
    7535                 7540                 7545             


Tyr Ile  Cys Gln Ile Lys Asn  Asp Ala Gly Met Arg  Glu Cys Ser 
    7550                 7555                 7560             


Ala Val  Leu Thr Val Leu Glu  Pro Ala Arg Ile Ile  Glu Lys Pro 
    7565                 7570                 7575             


Glu Pro  Met Thr Val Thr Thr  Gly Asn Pro Phe Ala  Leu Glu Cys 
    7580                 7585                 7590             


Val Val  Thr Gly Thr Pro Glu  Leu Ser Ala Lys Trp  Phe Lys Asp 
    7595                 7600                 7605             


Gly Arg  Glu Leu Ser Ala Asp  Ser Lys His His Ile  Thr Phe Ile 
    7610                 7615                 7620             


Asn Lys  Val Ala Ser Leu Lys  Ile Pro Cys Ala Glu  Met Ser Asp 
    7625                 7630                 7635             


Lys Gly  Leu Tyr Ser Phe Glu  Val Lys Asn Ser Val  Gly Lys Ser 
    7640                 7645                 7650             


Asn Cys  Thr Val Ser Val His  Val Ser Asp Arg Ile  Val Pro Pro 
    7655                 7660                 7665             


Ser Phe  Ile Arg Lys Leu Lys  Asp Val Asn Ala Ile  Leu Gly Ala 
    7670                 7675                 7680             


Ser Val  Val Leu Glu Cys Arg  Val Ser Gly Ser Ala  Pro Ile Ser 
    7685                 7690                 7695             


Val Gly  Trp Phe Gln Asp Gly  Asn Glu Ile Val Ser  Gly Pro Lys 
    7700                 7705                 7710             


Cys Gln  Ser Ser Phe Ser Glu  Asn Val Cys Thr Leu  Asn Leu Ser 
    7715                 7720                 7725             


Leu Leu  Glu Pro Ser Asp Thr  Gly Ile Tyr Thr Cys  Val Ala Ala 
    7730                 7735                 7740             


Asn Val  Ala Gly Ser Asp Glu  Cys Ser Ala Val Leu  Thr Val Gln 
    7745                 7750                 7755             


Glu Pro  Pro Ser Phe Glu Gln  Thr Pro Asp Ser Val  Glu Val Leu 
    7760                 7765                 7770             


Pro Gly  Met Ser Leu Thr Phe  Thr Ser Val Ile Arg  Gly Thr Pro 
    7775                 7780                 7785             


Pro Phe  Lys Val Lys Trp Phe  Lys Gly Ser Arg Glu  Leu Val Pro 
    7790                 7795                 7800             


Gly Glu  Ser Cys Asn Ile Ser  Leu Glu Asp Phe Val  Thr Glu Leu 
    7805                 7810                 7815             


Glu Leu  Phe Glu Val Gln Pro  Leu Glu Ser Gly Asp  Tyr Ser Cys 
    7820                 7825                 7830             


Leu Val  Thr Asn Asp Ala Gly  Ser Ala Ser Cys Thr  Thr His Leu 
    7835                 7840                 7845             


Phe Val  Lys Glu Pro Ala Thr  Phe Val Lys Arg Leu  Ala Asp Phe 
    7850                 7855                 7860             


Ser Val  Glu Thr Gly Ser Pro  Ile Val Leu Glu Ala  Thr Tyr Thr 
    7865                 7870                 7875             


Gly Thr  Pro Pro Ile Ser Val  Ser Trp Ile Lys Asp  Glu Tyr Leu 
    7880                 7885                 7890             


Ile Ser  Gln Ser Glu Arg Cys  Ser Ile Thr Met Thr  Glu Lys Ser 
    7895                 7900                 7905             


Thr Ile  Leu Glu Ile Leu Glu  Ser Thr Ile Glu Asp  Tyr Ala Gln 
    7910                 7915                 7920             


Tyr Ser  Cys Leu Ile Glu Asn  Glu Ala Gly Gln Asp  Ile Cys Glu 
    7925                 7930                 7935             


Ala Leu  Val Ser Val Leu Glu  Pro Pro Tyr Phe Ile  Glu Pro Leu 
    7940                 7945                 7950             


Glu His  Val Glu Ala Val Ile  Gly Glu Pro Ala Thr  Leu Gln Cys 
    7955                 7960                 7965             


Lys Val  Asp Gly Thr Pro Glu  Ile Arg Ile Ser Trp  Tyr Lys Glu 
    7970                 7975                 7980             


His Thr  Lys Leu Arg Ser Ala  Pro Ala Tyr Lys Met  Gln Phe Lys 
    7985                 7990                 7995             


Asn Asn  Val Ala Ser Leu Val  Ile Asn Lys Val Asp  His Ser Asp 
    8000                 8005                 8010             


Val Gly  Glu Tyr Ser Cys Lys  Ala Asp Asn Ser Val  Gly Ala Val 
    8015                 8020                 8025             


Ala Ser  Ser Ala Val Leu Val  Ile Lys Glu Arg Lys  Leu Pro Pro 
    8030                 8035                 8040             


Phe Phe  Ala Arg Lys Leu Lys  Asp Val His Glu Thr  Leu Gly Phe 
    8045                 8050                 8055             


Pro Val  Ala Phe Glu Cys Arg  Ile Asn Gly Ser Glu  Pro Leu Gln 
    8060                 8065                 8070             


Val Ser  Trp Tyr Lys Asp Gly  Val Leu Leu Lys Asp  Asp Ala Asn 
    8075                 8080                 8085             


Leu Gln  Thr Ser Phe Val His  Asn Val Ala Thr Leu  Gln Ile Leu 
    8090                 8095                 8100             


Gln Thr  Asp Gln Ser His Ile  Gly Gln Tyr Asn Cys  Ser Ala Ser 
    8105                 8110                 8115             


Asn Pro  Leu Gly Thr Ala Ser  Ser Ser Ala Lys Leu  Ile Leu Ser 
    8120                 8125                 8130             


Glu His  Glu Val Pro Pro Phe  Phe Asp Leu Lys Pro  Val Ser Val 
    8135                 8140                 8145             


Asp Leu  Ala Leu Gly Glu Ser  Gly Thr Phe Lys Cys  His Val Thr 
    8150                 8155                 8160             


Gly Thr  Ala Pro Ile Lys Ile  Thr Trp Ala Lys Asp  Asn Arg Glu 
    8165                 8170                 8175             


Ile Arg  Pro Gly Gly Asn Tyr  Lys Met Thr Leu Val  Glu Asn Thr 
    8180                 8185                 8190             


Ala Thr  Leu Thr Val Leu Lys  Val Gly Lys Gly Asp  Ala Gly Gln 
    8195                 8200                 8205             


Tyr Thr  Cys Tyr Ala Ser Asn  Ile Ala Gly Lys Asp  Ser Cys Ser 
    8210                 8215                 8220             


Ala His  Leu Gly Val Gln Glu  Pro Pro Arg Phe Ile  Lys Lys Leu 
    8225                 8230                 8235             


Glu Pro  Ser Arg Ile Val Lys  Gln Asp Glu Phe Thr  Arg Tyr Glu 
    8240                 8245                 8250             


Cys Lys  Ile Gly Gly Ser Pro  Glu Ile Lys Val Leu  Trp Tyr Lys 
    8255                 8260                 8265             


Asp Glu  Thr Glu Ile Gln Glu  Ser Ser Lys Phe Arg  Met Ser Phe 
    8270                 8275                 8280             


Val Asp  Ser Val Ala Val Leu  Glu Met His Asn Leu  Ser Val Glu 
    8285                 8290                 8295             


Asp Ser  Gly Asp Tyr Thr Cys  Glu Ala His Asn Ala  Ala Gly Ser 
    8300                 8305                 8310             


Ala Ser  Ser Ser Thr Ser Leu  Lys Val Lys Glu Pro  Pro Ile Phe 
    8315                 8320                 8325             


Arg Lys  Lys Pro His Pro Ile  Glu Thr Leu Lys Gly  Ala Asp Val 
    8330                 8335                 8340             


His Leu  Glu Cys Glu Leu Gln  Gly Thr Pro Pro Phe  His Val Ser 
    8345                 8350                 8355             


Trp Tyr  Lys Asp Lys Arg Glu  Leu Arg Ser Gly Lys  Lys Tyr Lys 
    8360                 8365                 8370             


Ile Met  Ser Glu Asn Phe Leu  Thr Ser Ile His Ile  Leu Asn Val 
    8375                 8380                 8385             


Asp Ala  Ala Asp Ile Gly Glu  Tyr Gln Cys Lys Ala  Thr Asn Asp 
    8390                 8395                 8400             


Val Gly  Ser Asp Thr Cys Val  Gly Ser Ile Ala Leu  Lys Ala Pro 
    8405                 8410                 8415             


Pro Arg  Phe Val Lys Lys Leu  Ser Asp Ile Ser Thr  Val Val Gly 
    8420                 8425                 8430             


Lys Glu  Val Gln Leu Gln Thr  Thr Ile Glu Gly Ala  Glu Pro Ile 
    8435                 8440                 8445             


Ser Val  Val Trp Phe Lys Asp  Lys Gly Glu Ile Val  Arg Glu Ser 
    8450                 8455                 8460             


Asp Asn  Ile Trp Ile Ser Tyr  Ser Glu Asn Ile Ala  Thr Leu Gln 
    8465                 8470                 8475             


Phe Ser  Arg Val Glu Pro Ala  Asn Ala Gly Lys Tyr  Thr Cys Gln 
    8480                 8485                 8490             


Ile Lys  Asn Asp Ala Gly Met  Gln Glu Cys Phe Ala  Thr Leu Ser 
    8495                 8500                 8505             


Val Leu  Glu Pro Ala Thr Ile  Val Glu Lys Pro Glu  Ser Ile Lys 
    8510                 8515                 8520             


Val Thr  Thr Gly Asp Thr Cys  Thr Leu Glu Cys Thr  Val Ala Gly 
    8525                 8530                 8535             


Thr Pro  Glu Leu Ser Thr Lys  Trp Phe Lys Asp Gly  Lys Glu Leu 
    8540                 8545                 8550             


Thr Ser  Asp Asn Lys Tyr Lys  Ile Ser Phe Phe Asn  Lys Val Ser 
    8555                 8560                 8565             


Gly Leu  Lys Ile Ile Asn Val  Ala Pro Ser Asp Ser  Gly Val Tyr 
    8570                 8575                 8580             


Ser Phe  Glu Val Gln Asn Pro  Val Gly Lys Asp Ser  Cys Thr Ala 
    8585                 8590                 8595             


Ser Leu  Gln Val Ser Asp Arg  Thr Val Pro Pro Ser  Phe Thr Arg 
    8600                 8605                 8610             


Lys Leu  Lys Glu Thr Asn Gly  Leu Ser Gly Ser Ser  Val Val Met 
    8615                 8620                 8625             


Glu Cys  Lys Val Tyr Gly Ser  Pro Pro Ile Ser Val  Ser Trp Phe 
    8630                 8635                 8640             


His Glu  Gly Asn Glu Ile Ser  Ser Gly Arg Lys Tyr  Gln Thr Thr 
    8645                 8650                 8655             


Leu Thr  Asp Asn Thr Cys Ala  Leu Thr Val Asn Met  Leu Glu Glu 
    8660                 8665                 8670             


Ser Asp  Ser Gly Asp Tyr Thr  Cys Ile Ala Thr Asn  Met Ala Gly 
    8675                 8680                 8685             


Ser Asp  Glu Cys Ser Ala Pro  Leu Thr Val Arg Glu  Pro Pro Ser 
    8690                 8695                 8700             


Phe Val  Gln Lys Pro Asp Pro  Met Asp Val Leu Thr  Gly Thr Asn 
    8705                 8710                 8715             


Val Thr  Phe Thr Ser Ile Val  Lys Gly Thr Pro Pro  Phe Ser Val 
    8720                 8725                 8730             


Ser Trp  Phe Lys Gly Ser Ser  Glu Leu Val Pro Gly  Asp Arg Cys 
    8735                 8740                 8745             


Asn Val  Ser Leu Glu Asp Ser  Val Ala Glu Leu Glu  Leu Phe Asp 
    8750                 8755                 8760             


Val Asp  Thr Ser Gln Ser Gly  Glu Tyr Thr Cys Ile  Val Ser Asn 
    8765                 8770                 8775             


Glu Ala  Gly Lys Ala Ser Cys  Thr Thr His Leu Tyr  Ile Lys Ala 
    8780                 8785                 8790             


Pro Ala  Lys Phe Val Lys Arg  Leu Asn Asp Tyr Ser  Ile Glu Lys 
    8795                 8800                 8805             


Gly Lys  Pro Leu Ile Leu Glu  Gly Thr Phe Thr Gly  Thr Pro Pro 
    8810                 8815                 8820             


Ile Ser  Val Thr Trp Lys Lys  Asn Gly Ile Asn Val  Thr Pro Ser 
    8825                 8830                 8835             


Gln Arg  Cys Asn Ile Thr Thr  Thr Glu Lys Ser Ala  Ile Leu Glu 
    8840                 8845                 8850             


Ile Pro  Ser Ser Thr Val Glu  Asp Ala Gly Gln Tyr  Asn Cys Tyr 
    8855                 8860                 8865             


Ile Glu  Asn Ala Ser Gly Lys  Asp Ser Cys Ser Ala  Gln Ile Leu 
    8870                 8875                 8880             


Ile Leu  Glu Pro Pro Tyr Phe  Val Lys Gln Leu Glu  Pro Val Lys 
    8885                 8890                 8895             


Val Ser  Val Gly Asp Ser Ala  Ser Leu Gln Cys Gln  Leu Ala Gly 
    8900                 8905                 8910             


Thr Pro  Glu Ile Gly Val Ser  Trp Tyr Lys Gly Asp  Thr Lys Leu 
    8915                 8920                 8925             


Arg Pro  Thr Thr Thr Tyr Lys  Met His Phe Arg Asn  Asn Val Ala 
    8930                 8935                 8940             


Thr Leu  Val Phe Asn Gln Val  Asp Ile Asn Asp Ser  Gly Glu Tyr 
    8945                 8950                 8955             


Ile Cys  Lys Ala Glu Asn Ser  Val Gly Glu Val Ser  Ala Ser Thr 
    8960                 8965                 8970             


Phe Leu  Thr Val Gln Glu Gln  Lys Leu Pro Pro Ser  Phe Ser Arg 
    8975                 8980                 8985             


Gln Leu  Arg Asp Val Gln Glu  Thr Val Gly Leu Pro  Val Val Phe 
    8990                 8995                 9000             


Asp Cys  Ala Ile Ser Gly Ser  Glu Pro Ile Ser Val  Ser Trp Tyr 
    9005                 9010                 9015             


Lys Asp  Gly Lys Pro Leu Lys  Asp Ser Pro Asn Val  Gln Thr Ser 
    9020                 9025                 9030             


Phe Leu  Asp Asn Thr Ala Thr  Leu Asn Ile Phe Lys  Thr Asp Arg 
    9035                 9040                 9045             


Ser Leu  Ala Gly Gln Tyr Ser  Cys Thr Ala Thr Asn  Pro Ile Gly 
    9050                 9055                 9060             


Ser Ala  Ser Ser Ser Ala Arg  Leu Ile Leu Thr Glu  Gly Lys Asn 
    9065                 9070                 9075             


Pro Pro  Phe Phe Asp Ile Arg  Leu Ala Pro Val Asp  Ala Val Val 
    9080                 9085                 9090             


Gly Glu  Ser Ala Asp Phe Glu  Cys His Val Thr Gly  Thr Gln Pro 
    9095                 9100                 9105             


Ile Lys  Val Ser Trp Ala Lys  Asp Ser Arg Glu Ile  Arg Ser Gly 
    9110                 9115                 9120             


Gly Lys  Tyr Gln Ile Ser Tyr  Leu Glu Asn Ser Ala  His Leu Thr 
    9125                 9130                 9135             


Val Leu  Lys Val Asp Lys Gly  Asp Ser Gly Gln Tyr  Thr Cys Tyr 
    9140                 9145                 9150             


Ala Val  Asn Glu Val Gly Lys  Asp Ser Cys Thr Ala  Gln Leu Asn 
    9155                 9160                 9165             


Ile Lys  Glu Arg Leu Ile Pro  Pro Ser Phe Thr Lys  Arg Leu Ser 
    9170                 9175                 9180             


Glu Thr  Val Glu Glu Thr Glu  Gly Asn Ser Phe Lys  Leu Glu Gly 
    9185                 9190                 9195             


Arg Val  Ala Gly Ser Gln Pro  Ile Thr Val Ala Trp  Tyr Lys Asn 
    9200                 9205                 9210             


Asn Ile  Glu Ile Gln Pro Thr  Ser Asn Cys Glu Ile  Thr Phe Lys 
    9215                 9220                 9225             


Asn Asn  Thr Leu Val Leu Gln  Val Arg Lys Ala Gly  Met Asn Asp 
    9230                 9235                 9240             


Ala Gly  Leu Tyr Thr Cys Lys  Val Ser Asn Asp Ala  Gly Ser Ala 
    9245                 9250                 9255             


Leu Cys  Thr Ser Ser Ile Val  Ile Lys Glu Pro Lys  Lys Pro Pro 
    9260                 9265                 9270             


Val Phe  Asp Gln His Leu Thr  Pro Val Thr Val Ser  Glu Gly Glu 
    9275                 9280                 9285             


Tyr Val  Gln Leu Ser Cys His  Val Gln Gly Ser Glu  Pro Ile Arg 
    9290                 9295                 9300             


Ile Gln  Trp Leu Lys Ala Gly  Arg Glu Ile Lys Pro  Ser Asp Arg 
    9305                 9310                 9315             


Cys Ser  Phe Ser Phe Ala Ser  Gly Thr Ala Val Leu  Glu Leu Arg 
    9320                 9325                 9330             


Asp Val  Ala Lys Ala Asp Ser  Gly Asp Tyr Val Cys  Lys Ala Ser 
    9335                 9340                 9345             


Asn Val  Ala Gly Ser Asp Thr  Thr Lys Ser Lys Val  Thr Ile Lys 
    9350                 9355                 9360             


Asp Lys  Pro Ala Val Ala Pro  Ala Thr Lys Lys Ala  Ala Val Asp 
    9365                 9370                 9375             


Gly Arg  Leu Phe Phe Val Ser  Glu Pro Gln Ser Ile  Arg Val Val 
    9380                 9385                 9390             


Glu Lys  Thr Thr Ala Thr Phe  Ile Ala Lys Val Gly  Gly Asp Pro 
    9395                 9400                 9405             


Ile Pro  Asn Val Lys Trp Thr  Lys Gly Lys Trp Arg  Gln Leu Asn 
    9410                 9415                 9420             


Gln Gly  Gly Arg Val Phe Ile  His Gln Lys Gly Asp  Glu Ala Lys 
    9425                 9430                 9435             


Leu Glu  Ile Arg Asp Thr Thr  Lys Thr Asp Ser Gly  Leu Tyr Arg 
    9440                 9445                 9450             


Cys Val  Ala Phe Asn Glu His  Gly Glu Ile Glu Ser  Asn Val Asn 
    9455                 9460                 9465             


Leu Gln  Val Asp Glu Arg Lys  Lys Gln Glu Lys Ile  Glu Gly Asp 
    9470                 9475                 9480             


Leu Arg  Ala Met Leu Lys Lys  Thr Pro Ile Leu Lys  Lys Gly Ala 
    9485                 9490                 9495             


Gly Glu  Glu Glu Glu Ile Asp  Ile Met Glu Leu Leu  Lys Asn Val 
    9500                 9505                 9510             


Asp Pro  Lys Glu Tyr Glu Lys  Tyr Ala Arg Met Tyr  Gly Ile Thr 
    9515                 9520                 9525             


Asp Phe  Arg Gly Leu Leu Gln  Ala Phe Glu Leu Leu  Lys Gln Ser 
    9530                 9535                 9540             


Gln Glu  Glu Glu Thr His Arg  Leu Glu Ile Glu Glu  Ile Glu Arg 
    9545                 9550                 9555             


Ser Glu  Arg Asp Glu Lys Glu  Phe Glu Glu Leu Val  Ser Phe Ile 
    9560                 9565                 9570             


Gln Gln  Arg Leu Ser Gln Thr  Glu Pro Val Thr Leu  Ile Lys Asp 
    9575                 9580                 9585             


Ile Glu  Asn Gln Thr Val Leu  Lys Asp Asn Asp Ala  Val Phe Glu 
    9590                 9595                 9600             


Ile Asp  Ile Lys Ile Asn Tyr  Pro Glu Ile Lys Leu  Ser Trp Tyr 
    9605                 9610                 9615             


Lys Gly  Thr Glu Lys Leu Glu  Pro Ser Asp Lys Phe  Glu Ile Ser 
    9620                 9625                 9630             


Ile Asp  Gly Asp Arg His Thr  Leu Arg Val Lys Asn  Cys Gln Leu 
    9635                 9640                 9645             


Lys Asp  Gln Gly Asn Tyr Arg  Leu Val Cys Gly Pro  His Ile Ala 
    9650                 9655                 9660             


Ser Ala  Lys Leu Thr Val Ile  Glu Pro Ala Trp Glu  Arg His Leu 
    9665                 9670                 9675             


Gln Asp  Val Thr Leu Lys Glu  Gly Gln Thr Cys Thr  Met Thr Cys 
    9680                 9685                 9690             


Gln Phe  Ser Val Pro Asn Val  Lys Ser Glu Trp Phe  Arg Asn Gly 
    9695                 9700                 9705             


Arg Ile  Leu Lys Pro Gln Gly  Arg His Lys Thr Glu  Val Glu His 
    9710                 9715                 9720             


Lys Val  His Lys Leu Thr Ile  Ala Asp Val Arg Ala  Glu Asp Gln 
    9725                 9730                 9735             


Gly Gln  Tyr Thr Cys Lys Tyr  Glu Asp Leu Glu Thr  Ser Ala Glu 
    9740                 9745                 9750             


Leu Arg  Ile Glu Ala Glu Pro  Ile Gln Phe Thr Lys  Arg Ile Gln 
    9755                 9760                 9765             


Asn Ile  Val Val Ser Glu His  Gln Ser Ala Thr Phe  Glu Cys Glu 
    9770                 9775                 9780             


Val Ser  Phe Asp Asp Ala Ile  Val Thr Trp Tyr Lys  Gly Pro Thr 
    9785                 9790                 9795             


Glu Leu  Thr Glu Ser Gln Lys  Tyr Asn Phe Arg Asn  Asp Gly Arg 
    9800                 9805                 9810             


Cys His  Tyr Met Thr Ile His  Asn Val Thr Pro Asp  Asp Glu Gly 
    9815                 9820                 9825             


Val Tyr  Ser Val Ile Ala Arg  Leu Glu Pro Arg Gly  Glu Ala Arg 
    9830                 9835                 9840             


Ser Thr  Ala Glu Leu Tyr Leu  Thr Thr Lys Glu Ile  Lys Leu Glu 
    9845                 9850                 9855             


Leu Lys  Pro Pro Asp Ile Pro  Asp Ser Arg Val Pro  Ile Pro Thr 
    9860                 9865                 9870             


Met Pro  Ile Arg Ala Val Pro  Pro Glu Glu Ile Pro  Pro Val Val 
    9875                 9880                 9885             


Ala Pro  Pro Ile Pro Leu Leu  Leu Pro Thr Pro Glu  Glu Lys Lys 
    9890                 9895                 9900             


Pro Pro  Pro Lys Arg Ile Glu  Val Thr Lys Lys Ala  Val Lys Lys 
    9905                 9910                 9915             


Asp Ala  Lys Lys Val Val Ala  Lys Pro Lys Glu Met  Thr Pro Arg 
    9920                 9925                 9930             


Glu Glu  Ile Val Lys Lys Pro  Pro Pro Pro Thr Thr  Leu Ile Pro 
    9935                 9940                 9945             


Ala Lys  Ala Pro Glu Ile Ile  Asp Val Ser Ser Lys  Ala Glu Glu 
    9950                 9955                 9960             


Val Lys  Ile Met Thr Ile Thr  Arg Lys Lys Glu Val  Gln Lys Glu 
    9965                 9970                 9975             


Lys Glu  Ala Val Tyr Glu Lys  Lys Gln Ala Val His  Lys Glu Lys 
    9980                 9985                 9990             


Arg Val  Phe Ile Glu Ser Phe   Glu Glu Pro Tyr Asp   Glu Leu Glu 
    9995                 10000                 10005             


Val Glu   Pro Tyr Thr Glu Pro   Phe Glu Gln Pro Tyr   Tyr Glu Glu 
    10010                 10015                 10020             


Pro Asp   Glu Asp Tyr Glu Glu   Ile Lys Val Glu Ala   Lys Lys Glu 
    10025                 10030                 10035             


Val His   Glu Glu Trp Glu Glu   Asp Phe Glu Glu Gly   Gln Glu Tyr 
    10040                 10045                 10050             


Tyr Glu   Arg Glu Glu Gly Tyr   Asp Glu Gly Glu Glu   Glu Trp Glu 
    10055                 10060                 10065             


Glu Ala   Tyr Gln Glu Arg Glu   Val Ile Gln Val Gln   Lys Glu Val 
    10070                 10075                 10080             


Tyr Glu   Glu Ser His Glu Arg   Lys Val Pro Ala Lys   Val Pro Glu 
    10085                 10090                 10095             


Lys Lys   Ala Pro Pro Pro Pro   Lys Val Ile Lys Lys   Pro Val Ile 
    10100                 10105                 10110             


Glu Lys   Ile Glu Lys Thr Ser   Arg Arg Met Glu Glu   Glu Lys Val 
    10115                 10120                 10125             


Gln Val   Thr Lys Val Pro Glu   Val Ser Lys Lys Ile   Val Pro Gln 
    10130                 10135                 10140             


Lys Pro   Ser Arg Thr Pro Val   Gln Glu Glu Val Ile   Glu Val Lys 
    10145                 10150                 10155             


Val Pro   Ala Val His Thr Lys   Lys Met Val Ile Ser   Glu Glu Lys 
    10160                 10165                 10170             


Met Phe   Phe Ala Ser His Thr   Glu Glu Glu Val Ser   Val Thr Val 
    10175                 10180                 10185             


Pro Glu   Val Gln Lys Glu Ile   Val Thr Glu Glu Lys   Ile His Val 
    10190                 10195                 10200             


Ala Val   Ser Lys Arg Val Glu   Pro Pro Pro Lys Val   Pro Glu Leu 
    10205                 10210                 10215             


Pro Glu   Lys Pro Ala Pro Glu   Glu Val Ala Pro Val   Pro Ile Pro 
    10220                 10225                 10230             


Lys Lys   Val Glu Pro Pro Ala   Pro Lys Val Pro Glu   Val Pro Lys 
    10235                 10240                 10245             


Lys Pro   Val Pro Glu Glu Lys   Lys Pro Val Pro Val   Pro Lys Lys 
    10250                 10255                 10260             


Glu Pro   Ala Ala Pro Pro Lys   Val Pro Glu Val Pro   Lys Lys Pro 
    10265                 10270                 10275             


Val Pro   Glu Glu Lys Ile Pro   Val Pro Val Ala Lys   Lys Lys Glu 
    10280                 10285                 10290             


Ala Pro   Pro Ala Lys Val Pro   Glu Val Gln Lys Arg   Val Val Thr 
    10295                 10300                 10305             


Glu Glu   Lys Ile Thr Ile Val   Thr Gln Arg Glu Glu   Ser Pro Pro 
    10310                 10315                 10320             


Pro Ala   Val Pro Glu Ile Pro   Lys Lys Lys Val Pro   Glu Glu Arg 
    10325                 10330                 10335             


Lys Pro   Val Pro Arg Lys Glu   Glu Glu Val Pro Pro   Pro Pro Lys 
    10340                 10345                 10350             


Val Pro   Ala Leu Pro Lys Lys   Pro Val Pro Glu Glu   Lys Val Ala 
    10355                 10360                 10365             


Val Pro   Val Pro Val Ala Lys   Lys Ala Pro Pro Pro   Arg Ala Glu 
    10370                 10375                 10380             


Val Ser   Lys Lys Thr Val Val   Glu Glu Lys Arg Phe   Val Ala Glu 
    10385                 10390                 10395             


Glu Lys   Leu Ser Phe Ala Val   Pro Gln Arg Val Glu   Val Thr Arg 
    10400                 10405                 10410             


His Glu   Val Ser Ala Glu Glu   Glu Trp Ser Tyr Ser   Glu Glu Glu 
    10415                 10420                 10425             


Glu Gly   Val Ser Ile Ser Val   Tyr Arg Glu Glu Glu   Arg Glu Glu 
    10430                 10435                 10440             


Glu Glu   Glu Ala Glu Val Thr   Glu Tyr Glu Val Met   Glu Glu Pro 
    10445                 10450                 10455             


Glu Glu   Tyr Val Val Glu Glu   Lys Leu His Ile Ile   Ser Lys Arg 
    10460                 10465                 10470             


Val Glu   Ala Glu Pro Ala Glu   Val Thr Glu Arg Gln   Glu Lys Lys 
    10475                 10480                 10485             


Ile Val   Leu Lys Pro Lys Ile   Pro Ala Lys Ile Glu   Glu Pro Pro 
    10490                 10495                 10500             


Pro Ala   Lys Val Pro Glu Ala   Pro Lys Lys Ile Val   Pro Glu Lys 
    10505                 10510                 10515             


Lys Val   Pro Ala Pro Val Pro   Lys Lys Glu Lys Val   Pro Pro Pro 
    10520                 10525                 10530             


Lys Val   Pro Glu Glu Pro Lys   Lys Pro Val Pro Glu   Lys Lys Val 
    10535                 10540                 10545             


Pro Pro   Lys Val Ile Lys Met   Glu Glu Pro Leu Pro   Ala Lys Val 
    10550                 10555                 10560             


Thr Glu   Arg His Met Gln Ile   Thr Gln Glu Glu Lys   Val Leu Val 
    10565                 10570                 10575             


Ala Val   Thr Lys Lys Glu Ala   Pro Pro Lys Ala Arg   Val Pro Glu 
    10580                 10585                 10590             


Glu Pro   Lys Arg Ala Val Pro   Glu Glu Lys Val Leu   Lys Leu Lys 
    10595                 10600                 10605             


Pro Lys   Arg Glu Glu Glu Pro   Pro Ala Lys Val Thr   Glu Phe Arg 
    10610                 10615                 10620             


Lys Arg   Val Val Lys Glu Glu   Lys Val Ser Ile Glu   Ala Pro Lys 
    10625                 10630                 10635             


Arg Glu   Pro Gln Pro Ile Lys   Glu Val Thr Ile Met   Glu Glu Lys 
    10640                 10645                 10650             


Glu Arg   Ala Tyr Thr Leu Glu   Glu Glu Ala Val Ser   Val Gln Arg 
    10655                 10660                 10665             


Glu Glu   Glu Tyr Glu Glu Tyr   Glu Glu Tyr Asp Tyr   Lys Glu Phe 
    10670                 10675                 10680             


Glu Glu   Tyr Glu Pro Thr Glu   Glu Tyr Asp Gln Tyr   Glu Glu Tyr 
    10685                 10690                 10695             


Glu Glu   Arg Glu Tyr Glu Arg   Tyr Glu Glu His Glu   Glu Tyr Ile 
    10700                 10705                 10710             


Thr Glu   Pro Glu Lys Pro Ile   Pro Val Lys Pro Val   Pro Glu Glu 
    10715                 10720                 10725             


Pro Val   Pro Thr Lys Pro Lys   Ala Pro Pro Ala Lys   Val Leu Lys 
    10730                 10735                 10740             


Lys Ala   Val Pro Glu Glu Lys   Val Pro Val Pro Ile   Pro Lys Lys 
    10745                 10750                 10755             


Leu Lys   Pro Pro Pro Pro Lys   Val Pro Glu Glu Pro   Lys Lys Val 
    10760                 10765                 10770             


Phe Glu   Glu Lys Ile Arg Ile   Ser Ile Thr Lys Arg   Glu Lys Glu 
    10775                 10780                 10785             


Gln Val   Thr Glu Pro Ala Ala   Lys Val Pro Met Lys   Pro Lys Arg 
    10790                 10795                 10800             


Val Val   Ala Glu Glu Lys Val   Pro Val Pro Arg Lys   Glu Val Ala 
    10805                 10810                 10815             


Pro Pro   Val Arg Val Pro Glu   Val Pro Lys Glu Leu   Glu Pro Glu 
    10820                 10825                 10830             


Glu Val   Ala Phe Glu Glu Glu   Val Val Thr His Val   Glu Glu Tyr 
    10835                 10840                 10845             


Leu Val   Glu Glu Glu Glu Glu   Tyr Ile His Glu Glu   Glu Glu Phe 
    10850                 10855                 10860             


Ile Thr   Glu Glu Glu Val Val   Pro Val Ile Pro Val   Lys Val Pro 
    10865                 10870                 10875             


Glu Val   Pro Arg Lys Pro Val   Pro Glu Glu Lys Lys   Pro Val Pro 
    10880                 10885                 10890             


Val Pro   Lys Lys Lys Glu Ala   Pro Pro Ala Lys Val   Pro Glu Val 
    10895                 10900                 10905             


Pro Lys   Lys Pro Glu Glu Lys   Val Pro Val Leu Ile   Pro Lys Lys 
    10910                 10915                 10920             


Glu Lys   Pro Pro Pro Ala Lys   Val Pro Glu Val Pro   Lys Lys Pro 
    10925                 10930                 10935             


Val Pro   Glu Glu Lys Val Pro   Val Pro Val Pro Lys   Lys Val Glu 
    10940                 10945                 10950             


Ala Pro   Pro Ala Lys Val Pro   Glu Val Pro Lys Lys   Pro Val Pro 
    10955                 10960                 10965             


Glu Lys   Lys Val Pro Val Pro   Ala Pro Lys Lys Val   Glu Ala Pro 
    10970                 10975                 10980             


Pro Ala   Lys Val Pro Glu Val   Pro Lys Lys Leu Ile   Pro Glu Glu 
    10985                 10990                 10995             


Lys Lys   Pro Thr Pro Val Pro   Lys Lys Val Glu Ala   Pro Pro Pro 
    11000                 11005                 11010             


Lys Val   Pro Lys Lys Arg Glu   Pro Val Pro Val Pro   Val Ala Leu 
    11015                 11020                 11025             


Pro Gln   Glu Glu Glu Val Leu   Phe Glu Glu Glu Ile   Val Pro Glu 
    11030                 11035                 11040             


Glu Glu   Val Leu Pro Glu Glu   Glu Glu Val Leu Pro   Glu Glu Glu 
    11045                 11050                 11055             


Glu Val   Leu Pro Glu Glu Glu   Glu Val Leu Pro Glu   Glu Glu Glu 
    11060                 11065                 11070             


Ile Pro   Pro Glu Glu Glu Glu   Val Pro Pro Glu Glu   Glu Tyr Val 
    11075                 11080                 11085             


Pro Glu   Glu Glu Glu Phe Val   Pro Glu Glu Glu Val   Leu Pro Glu 
    11090                 11095                 11100             


Val Lys   Pro Lys Val Pro Val   Pro Ala Pro Val Pro   Glu Ile Lys 
    11105                 11110                 11115             


Lys Lys   Val Thr Glu Lys Lys   Val Val Ile Pro Lys   Lys Glu Glu 
    11120                 11125                 11130             


Ala Pro   Pro Ala Lys Val Pro   Glu Val Pro Lys Lys   Val Glu Glu 
    11135                 11140                 11145             


Lys Arg   Ile Ile Leu Pro Lys   Glu Glu Glu Val Leu   Pro Val Glu 
    11150                 11155                 11160             


Val Thr   Glu Glu Pro Glu Glu   Glu Pro Ile Ser Glu   Glu Glu Ile 
    11165                 11170                 11175             


Pro Glu   Glu Pro Pro Ser Ile   Glu Glu Val Glu Glu   Val Ala Pro 
    11180                 11185                 11190             


Pro Arg   Val Pro Glu Val Ile   Lys Lys Ala Val Pro   Glu Ala Pro 
    11195                 11200                 11205             


Thr Pro   Val Pro Lys Lys Val   Glu Ala Pro Pro Ala   Lys Val Ser 
    11210                 11215                 11220             


Lys Lys   Ile Pro Glu Glu Lys   Val Pro Val Pro Val   Gln Lys Lys 
    11225                 11230                 11235             


Glu Ala   Pro Pro Ala Lys Val   Pro Glu Val Pro Lys   Lys Val Pro 
    11240                 11245                 11250             


Glu Lys   Lys Val Leu Val Pro   Lys Lys Glu Ala Val   Pro Pro Ala 
    11255                 11260                 11265             


Lys Gly   Arg Thr Val Leu Glu   Glu Lys Val Ser Val   Ala Phe Arg 
    11270                 11275                 11280             


Gln Glu   Val Val Val Lys Glu   Arg Leu Glu Leu Glu   Val Val Glu 
    11285                 11290                 11295             


Ala Glu   Val Glu Glu Ile Pro   Glu Glu Glu Glu Phe   His Glu Val 
    11300                 11305                 11310             


Glu Glu   Tyr Phe Glu Glu Gly   Glu Phe His Glu Val   Glu Glu Phe 
    11315                 11320                 11325             


Ile Lys   Leu Glu Gln His Arg   Val Glu Glu Glu His   Arg Val Glu 
    11330                 11335                 11340             


Lys Val   His Arg Val Ile Glu   Val Phe Glu Ala Glu   Glu Val Glu 
    11345                 11350                 11355             


Val Phe   Glu Lys Pro Lys Ala   Pro Pro Lys Gly Pro   Glu Ile Ser 
    11360                 11365                 11370             


Glu Lys   Ile Ile Pro Pro Lys   Lys Pro Pro Thr Lys   Val Val Pro 
    11375                 11380                 11385             


Arg Lys   Glu Pro Pro Ala Lys   Val Pro Glu Val Pro   Lys Lys Ile 
    11390                 11395                 11400             


Val Val   Glu Glu Lys Val Arg   Val Pro Glu Glu Pro   Arg Val Pro 
    11405                 11410                 11415             


Pro Thr   Lys Val Pro Asp Val   Leu Pro Pro Lys Glu   Val Val Pro 
    11420                 11425                 11430             


Glu Lys   Lys Val Pro Val Pro   Pro Ala Lys Lys Pro   Glu Ala Pro 
    11435                 11440                 11445             


Pro Pro   Lys Val Pro Glu Ala   Pro Lys Glu Val Val   Pro Glu Lys 
    11450                 11455                 11460             


Lys Val   Pro Val Pro Pro Pro   Lys Lys Pro Glu Val   Pro Pro Thr 
    11465                 11470                 11475             


Lys Val   Pro Glu Val Pro Lys   Ala Ala Val Pro Glu   Lys Lys Val 
    11480                 11485                 11490             


Pro Glu   Ala Ile Pro Pro Lys   Pro Glu Ser Pro Pro   Pro Glu Val 
    11495                 11500                 11505             


Pro Glu   Ala Pro Lys Glu Val   Val Pro Glu Lys Lys   Val Pro Ala 
    11510                 11515                 11520             


Ala Pro   Pro Lys Lys Pro Glu   Val Thr Pro Val Lys   Val Pro Glu 
    11525                 11530                 11535             


Ala Pro   Lys Glu Val Val Pro   Glu Lys Lys Val Pro   Val Pro Pro 
    11540                 11545                 11550             


Pro Lys   Lys Pro Glu Val Pro   Pro Thr Lys Val Pro   Glu Val Pro 
    11555                 11560                 11565             


Lys Val   Ala Val Pro Glu Lys   Lys Val Pro Glu Ala   Ile Pro Pro 
    11570                 11575                 11580             


Lys Pro   Glu Ser Pro Pro Pro   Glu Val Phe Glu Glu   Pro Glu Glu 
    11585                 11590                 11595             


Val Ala   Leu Glu Glu Pro Pro   Ala Glu Val Val Glu   Glu Pro Glu 
    11600                 11605                 11610             


Pro Ala   Ala Pro Pro Gln Val   Thr Val Pro Pro Lys   Lys Pro Val 
    11615                 11620                 11625             


Pro Glu   Lys Lys Ala Pro Ala   Val Val Ala Lys Lys   Pro Glu Leu 
    11630                 11635                 11640             


Pro Pro   Val Lys Val Pro Glu   Val Pro Lys Glu Val   Val Pro Glu 
    11645                 11650                 11655             


Lys Lys   Val Pro Leu Val Val   Pro Lys Lys Pro Glu   Ala Pro Pro 
    11660                 11665                 11670             


Ala Lys   Val Pro Glu Val Pro   Lys Glu Val Val Pro   Glu Lys Lys 
    11675                 11680                 11685             


Val Ala   Val Pro Lys Lys Pro   Glu Val Pro Pro Ala   Lys Val Pro 
    11690                 11695                 11700             


Glu Val   Pro Lys Lys Pro Val   Leu Glu Glu Lys Pro   Ala Val Pro 
    11705                 11710                 11715             


Val Pro   Glu Arg Ala Glu Ser   Pro Pro Pro Glu Val   Tyr Glu Glu 
    11720                 11725                 11730             


Pro Glu   Glu Ile Ala Pro Glu   Glu Glu Ile Ala Pro   Glu Glu Glu 
    11735                 11740                 11745             


Lys Pro   Val Pro Val Ala Glu   Glu Glu Glu Pro Glu   Val Pro Pro 
    11750                 11755                 11760             


Pro Ala   Val Pro Glu Glu Pro   Lys Lys Ile Ile Pro   Glu Lys Lys 
    11765                 11770                 11775             


Val Pro   Val Ile Lys Lys Pro   Glu Ala Pro Pro Pro   Lys Glu Pro 
    11780                 11785                 11790             


Glu Pro   Glu Lys Val Ile Glu   Lys Pro Lys Leu Lys   Pro Arg Pro 
    11795                 11800                 11805             


Pro Pro   Pro Pro Pro Ala Pro   Pro Lys Glu Asp Val   Lys Glu Lys 
    11810                 11815                 11820             


Ile Phe   Gln Leu Lys Ala Ile   Pro Lys Lys Lys Val   Pro Glu Lys 
    11825                 11830                 11835             


Pro Gln   Val Pro Glu Lys Val   Glu Leu Thr Pro Leu   Lys Val Pro 
    11840                 11845                 11850             


Gly Gly   Glu Lys Lys Val Arg   Lys Leu Leu Pro Glu   Arg Lys Pro 
    11855                 11860                 11865             


Glu Pro   Lys Glu Glu Val Val   Leu Lys Ser Val Leu   Arg Lys Arg 
    11870                 11875                 11880             


Pro Glu   Glu Glu Glu Pro Lys   Val Glu Pro Lys Lys   Leu Glu Lys 
    11885                 11890                 11895             


Val Lys   Lys Pro Ala Val Pro   Glu Pro Pro Pro Pro   Lys Pro Val 
    11900                 11905                 11910             


Glu Glu   Val Glu Val Pro Thr   Val Thr Lys Arg Glu   Arg Lys Ile 
    11915                 11920                 11925             


Pro Glu   Pro Thr Lys Val Pro   Glu Ile Lys Pro Ala   Ile Pro Leu 
    11930                 11935                 11940             


Pro Ala   Pro Glu Pro Lys Pro   Lys Pro Glu Ala Glu   Val Lys Thr 
    11945                 11950                 11955             


Ile Lys   Pro Pro Pro Val Glu   Pro Glu Pro Thr Pro   Ile Ala Ala 
    11960                 11965                 11970             


Pro Val   Thr Val Pro Val Val   Gly Lys Lys Ala Glu   Ala Lys Ala 
    11975                 11980                 11985             


Pro Lys   Glu Glu Ala Ala Lys   Pro Lys Gly Pro Ile   Lys Gly Val 
    11990                 11995                 12000             


Pro Lys   Lys Thr Pro Ser Pro   Ile Glu Ala Glu Arg   Arg Lys Leu 
    12005                 12010                 12015             


Arg Pro   Gly Ser Gly Gly Glu   Lys Pro Pro Asp Glu   Ala Pro Phe 
    12020                 12025                 12030             


Thr Tyr   Gln Leu Lys Ala Val   Pro Leu Lys Phe Val   Lys Glu Ile 
    12035                 12040                 12045             


Lys Asp   Ile Ile Leu Thr Glu   Ser Glu Phe Val Gly   Ser Ser Ala 
    12050                 12055                 12060             


Ile Phe   Glu Cys Leu Val Ser   Pro Ser Thr Ala Ile   Thr Thr Trp 
    12065                 12070                 12075             


Met Lys   Asp Gly Ser Asn Ile   Arg Glu Ser Pro Lys   His Arg Phe 
    12080                 12085                 12090             


Ile Ala   Asp Gly Lys Asp Arg   Lys Leu His Ile Ile   Asp Val Gln 
    12095                 12100                 12105             


Leu Ser   Asp Ala Gly Glu Tyr   Thr Cys Val Leu Arg   Leu Gly Asn 
    12110                 12115                 12120             


Lys Glu   Lys Thr Ser Thr Ala   Lys Leu Val Val Glu   Glu Leu Pro 
    12125                 12130                 12135             


Val Arg   Phe Val Lys Thr Leu   Glu Glu Glu Val Thr   Val Val Lys 
    12140                 12145                 12150             


Gly Gln   Pro Leu Tyr Leu Ser   Cys Glu Leu Asn Lys   Glu Arg Asp 
    12155                 12160                 12165             


Val Val   Trp Arg Lys Asp Gly   Lys Ile Val Val Glu   Lys Pro Gly 
    12170                 12175                 12180             


Arg Ile   Val Pro Gly Val Ile   Gly Leu Met Arg Ala   Leu Thr Ile 
    12185                 12190                 12195             


Asn Asp   Ala Asp Asp Thr Asp   Ala Gly Thr Tyr Thr   Val Thr Val 
    12200                 12205                 12210             


Glu Asn   Ala Asn Asn Leu Glu   Cys Ser Ser Cys Val   Lys Val Val 
    12215                 12220                 12225             


Glu Val   Ile Arg Asp Trp Leu   Val Lys Pro Ile Arg   Asp Gln His 
    12230                 12235                 12240             


Val Lys   Pro Lys Gly Thr Ala   Ile Phe Ala Cys Asp   Ile Ala Lys 
    12245                 12250                 12255             


Asp Thr   Pro Asn Ile Lys Trp   Phe Lys Gly Tyr Asp   Glu Ile Pro 
    12260                 12265                 12270             


Ala Glu   Pro Asn Asp Lys Thr   Glu Ile Leu Arg Asp   Gly Asn His 
    12275                 12280                 12285             


Leu Tyr   Leu Lys Ile Lys Asn   Ala Met Pro Glu Asp   Ile Ala Glu 
    12290                 12295                 12300             


Tyr Ala   Val Glu Ile Glu Gly   Lys Arg Tyr Pro Ala   Lys Leu Thr 
    12305                 12310                 12315             


Leu Gly   Glu Arg Glu Val Glu   Leu Leu Lys Pro Ile   Glu Asp Val 
    12320                 12325                 12330             


Thr Ile   Tyr Glu Lys Glu Ser   Ala Ser Phe Asp Ala   Glu Ile Ser 
    12335                 12340                 12345             


Glu Ala   Asp Ile Pro Gly Gln   Trp Lys Leu Lys Gly   Glu Leu Leu 
    12350                 12355                 12360             


Arg Pro   Ser Pro Thr Cys Glu   Ile Lys Ala Glu Gly   Gly Lys Arg 
    12365                 12370                 12375             


Phe Leu   Thr Leu Arg Lys Val   Lys Leu Asp Gln Ala   Gly Glu Val 
    12380                 12385                 12390             


Leu Tyr   Gln Ala Leu Asn Ala   Ile Thr Thr Ala Ile   Leu Thr Val 
    12395                 12400                 12405             


Lys Glu   Ile Glu Leu Asp Phe   Ala Val Pro Leu Lys   Asp Val Thr 
    12410                 12415                 12420             


Val Pro   Glu Arg Arg Gln Ala   Arg Phe Glu Cys Val   Leu Thr Arg 
    12425                 12430                 12435             


Glu Ala   Asn Val Ile Trp Ser   Lys Gly Pro Asp Ile   Ile Lys Ser 
    12440                 12445                 12450             


Ser Asp   Lys Phe Asp Ile Ile   Ala Asp Gly Lys Lys   His Ile Leu 
    12455                 12460                 12465             


Val Ile   Asn Asp Ser Gln Phe   Asp Asp Glu Gly Val   Tyr Thr Ala 
    12470                 12475                 12480             


Glu Val   Glu Gly Lys Lys Thr   Ser Ala Arg Leu Phe   Val Thr Gly 
    12485                 12490                 12495             


Ile Arg   Leu Lys Phe Met Ser   Pro Leu Glu Asp Gln   Thr Val Lys 
    12500                 12505                 12510             


Glu Gly   Glu Thr Ala Thr Phe   Val Cys Glu Leu Ser   His Glu Lys 
    12515                 12520                 12525             


Met His   Val Val Trp Phe Lys   Asn Asp Ala Lys Leu   His Thr Ser 
    12530                 12535                 12540             


Arg Thr   Val Leu Ile Ser Ser   Glu Gly Lys Thr His   Lys Leu Glu 
    12545                 12550                 12555             


Met Lys   Glu Val Thr Leu Asp   Asp Ile Ser Gln Ile   Lys Ala Gln 
    12560                 12565                 12570             


Val Lys   Glu Leu Ser Ser Thr   Ala Gln Leu Lys Val   Leu Glu Ala 
    12575                 12580                 12585             


Asp Pro   Tyr Phe Thr Val Lys   Leu His Asp Lys Thr   Ala Val Glu 
    12590                 12595                 12600             


Lys Asp   Glu Ile Thr Leu Lys   Cys Glu Val Ser Lys   Asp Val Pro 
    12605                 12610                 12615             


Val Lys   Trp Phe Lys Asp Gly   Glu Glu Ile Val Pro   Ser Pro Lys 
    12620                 12625                 12630             


Tyr Ser   Ile Lys Ala Asp Gly   Leu Arg Arg Ile Leu   Lys Ile Lys 
    12635                 12640                 12645             


Lys Ala   Asp Leu Lys Asp Lys   Gly Glu Tyr Val Cys   Asp Cys Gly 
    12650                 12655                 12660             


Thr Asp   Lys Thr Lys Ala Asn   Val Thr Val Glu Ala   Arg Leu Ile 
    12665                 12670                 12675             


Lys Val   Glu Lys Pro Leu Tyr   Gly Val Glu Val Phe   Val Gly Glu 
    12680                 12685                 12690             


Thr Ala   His Phe Glu Ile Glu   Leu Ser Glu Pro Asp   Val His Gly 
    12695                 12700                 12705             


Gln Trp   Lys Leu Lys Gly Gln   Pro Leu Thr Ala Ser   Pro Asp Cys 
    12710                 12715                 12720             


Glu Ile   Ile Glu Asp Gly Lys   Lys His Ile Leu Ile   Leu His Asn 
    12725                 12730                 12735             


Cys Gln   Leu Gly Met Thr Gly   Glu Val Ser Phe Gln   Ala Ala Asn 
    12740                 12745                 12750             


Ala Lys   Ser Ala Ala Asn Leu   Lys Val Lys Glu Leu   Pro Leu Ile 
    12755                 12760                 12765             


Phe Ile   Thr Pro Leu Ser Asp   Val Lys Val Phe Glu   Lys Asp Glu 
    12770                 12775                 12780             


Ala Lys   Phe Glu Cys Glu Val   Ser Arg Glu Pro Lys   Thr Phe Arg 
    12785                 12790                 12795             


Trp Leu   Lys Gly Thr Gln Glu   Ile Thr Gly Asp Asp   Arg Phe Glu 
    12800                 12805                 12810             


Leu Ile   Lys Asp Gly Thr Lys   His Ser Met Val Ile   Lys Ser Ala 
    12815                 12820                 12825             


Ala Phe   Glu Asp Glu Ala Lys   Tyr Met Phe Glu Ala   Glu Asp Lys 
    12830                 12835                 12840             


His Thr   Ser Gly Lys Leu Ile   Ile Glu Gly Ile Arg   Leu Lys Phe 
    12845                 12850                 12855             


Leu Thr   Pro Leu Lys Asp Val   Thr Ala Lys Glu Lys   Glu Ser Ala 
    12860                 12865                 12870             


Val Phe   Thr Val Glu Leu Ser   His Asp Asn Ile Arg   Val Lys Trp 
    12875                 12880                 12885             


Phe Lys   Asn Asp Gln Arg Leu   His Thr Thr Arg Ser   Val Ser Met 
    12890                 12895                 12900             


Gln Asp   Glu Gly Lys Thr His   Ser Ile Thr Phe Lys   Asp Leu Ser 
    12905                 12910                 12915             


Ile Asp   Asp Thr Ser Gln Ile   Arg Val Glu Ala Met   Gly Met Ser 
    12920                 12925                 12930             


Ser Glu   Ala Lys Leu Thr Val   Leu Glu Gly Asp Pro   Tyr Phe Thr 
    12935                 12940                 12945             


Gly Lys   Leu Gln Asp Tyr Thr   Gly Val Glu Lys Asp   Glu Val Ile 
    12950                 12955                 12960             


Leu Gln   Cys Glu Ile Ser Lys   Ala Asp Ala Pro Val   Lys Trp Phe 
    12965                 12970                 12975             


Lys Asp   Gly Lys Glu Ile Lys   Pro Ser Lys Asn Ala   Val Ile Lys 
    12980                 12985                 12990             


Ala Asp   Gly Lys Lys Arg Met   Leu Ile Leu Lys Lys   Ala Leu Lys 
    12995                 13000                 13005             


Ser Asp   Ile Gly Gln Tyr Thr   Cys Asp Cys Gly Thr   Asp Lys Thr 
    13010                 13015                 13020             


Ser Gly   Lys Leu Asp Ile Glu   Asp Arg Glu Ile Lys   Leu Val Arg 
    13025                 13030                 13035             


Pro Leu   His Ser Val Glu Val   Met Glu Thr Glu Thr   Ala Arg Phe 
    13040                 13045                 13050             


Glu Thr   Glu Ile Ser Glu Asp   Asp Ile His Ala Asn   Trp Lys Leu 
    13055                 13060                 13065             


Lys Gly   Glu Ala Leu Leu Gln   Thr Pro Asp Cys Glu   Ile Lys Glu 
    13070                 13075                 13080             


Glu Gly   Lys Ile His Ser Leu   Val Leu His Asn Cys   Arg Leu Asp 
    13085                 13090                 13095             


Gln Thr   Gly Gly Val Asp Phe   Gln Ala Ala Asn Val   Lys Ser Ser 
    13100                 13105                 13110             


Ala His   Leu Arg Val Lys Pro   Arg Val Ile Gly Leu   Leu Arg Pro 
    13115                 13120                 13125             


Leu Lys   Asp Val Thr Val Thr   Ala Gly Glu Thr Ala   Thr Phe Asp 
    13130                 13135                 13140             


Cys Glu   Leu Ser Tyr Glu Asp   Ile Pro Val Glu Trp   Tyr Leu Lys 
    13145                 13150                 13155             


Gly Lys   Lys Leu Glu Pro Ser   Asp Lys Val Val Pro   Arg Ser Glu 
    13160                 13165                 13170             


Gly Lys   Val His Thr Leu Thr   Leu Arg Asp Val Lys   Leu Glu Asp 
    13175                 13180                 13185             


Ala Gly   Glu Val Gln Leu Thr   Ala Lys Asp Phe Lys   Thr His Ala 
    13190                 13195                 13200             


Asn Leu   Phe Val Lys Glu Pro   Pro Val Glu Phe Thr   Lys Pro Leu 
    13205                 13210                 13215             


Glu Asp   Gln Thr Val Glu Glu   Gly Ala Thr Ala Val   Leu Glu Cys 
    13220                 13225                 13230             


Glu Val   Ser Arg Glu Asn Ala   Lys Val Lys Trp Phe   Lys Asn Gly 
    13235                 13240                 13245             


Thr Glu   Ile Leu Lys Ser Lys   Lys Tyr Glu Ile Val   Ala Asp Gly 
    13250                 13255                 13260             


Arg Val   Arg Lys Leu Val Ile   His Asp Cys Thr Pro   Glu Asp Ile 
    13265                 13270                 13275             


Lys Thr   Tyr Thr Cys Asp Ala   Lys Asp Phe Lys Thr   Ser Cys Asn 
    13280                 13285                 13290             


Leu Asn   Val Val Pro Pro His   Val Glu Phe Leu Arg   Pro Leu Thr 
    13295                 13300                 13305             


Asp Leu   Gln Val Arg Glu Lys   Glu Met Ala Arg Phe   Glu Cys Glu 
    13310                 13315                 13320             


Leu Ser   Arg Glu Asn Ala Lys   Val Lys Trp Phe Lys   Asp Gly Ala 
    13325                 13330                 13335             


Glu Ile   Lys Lys Gly Lys Lys   Tyr Asp Ile Ile Ser   Lys Gly Ala 
    13340                 13345                 13350             


Val Arg   Ile Leu Val Ile Asn   Lys Cys Leu Leu Asp   Asp Glu Ala 
    13355                 13360                 13365             


Glu Tyr   Ser Cys Glu Val Arg   Thr Ala Arg Thr Ser   Gly Met Leu 
    13370                 13375                 13380             


Thr Val   Leu Glu Glu Glu Ala   Val Phe Thr Lys Asn   Leu Ala Asn 
    13385                 13390                 13395             


Ile Glu   Val Ser Glu Thr Asp   Thr Ile Lys Leu Val   Cys Glu Val 
    13400                 13405                 13410             


Ser Lys   Pro Gly Ala Glu Val   Ile Trp Tyr Lys Gly   Asp Glu Glu 
    13415                 13420                 13425             


Ile Ile   Glu Thr Gly Arg Tyr   Glu Ile Leu Thr Glu   Gly Arg Lys 
    13430                 13435                 13440             


Arg Ile   Leu Val Ile Gln Asn   Ala His Leu Glu Asp   Ala Gly Asn 
    13445                 13450                 13455             


Tyr Asn   Cys Arg Leu Pro Ser   Ser Arg Thr Asp Gly   Lys Val Lys 
    13460                 13465                 13470             


Val His   Glu Leu Ala Ala Glu   Phe Ile Ser Lys Pro   Gln Asn Leu 
    13475                 13480                 13485             


Glu Ile   Leu Glu Gly Glu Lys   Ala Glu Phe Val Cys   Ser Ile Ser 
    13490                 13495                 13500             


Lys Glu   Ser Phe Pro Val Gln   Trp Lys Arg Asp Asp   Lys Thr Leu 
    13505                 13510                 13515             


Glu Ser   Gly Asp Lys Tyr Asp   Val Ile Ala Asp Gly   Lys Lys Arg 
    13520                 13525                 13530             


Val Leu   Val Val Lys Asp Ala   Thr Leu Gln Asp Met   Gly Thr Tyr 
    13535                 13540                 13545             


Val Val   Met Val Gly Ala Ala   Arg Ala Ala Ala His   Leu Thr Val 
    13550                 13555                 13560             


Ile Glu   Lys Leu Arg Ile Val   Val Pro Leu Lys Asp   Thr Arg Val 
    13565                 13570                 13575             


Lys Glu   Gln Gln Glu Val Val   Phe Asn Cys Glu Val   Asn Thr Glu 
    13580                 13585                 13590             


Gly Ala   Lys Ala Lys Trp Phe   Arg Asn Glu Glu Ala   Ile Phe Asp 
    13595                 13600                 13605             


Ser Ser   Lys Tyr Ile Ile Leu   Gln Lys Asp Leu Val   Tyr Thr Leu 
    13610                 13615                 13620             


Arg Ile   Arg Asp Ala His Leu   Asp Asp Gln Ala Asn   Tyr Asn Val 
    13625                 13630                 13635             


Ser Leu   Thr Asn His Arg Gly   Glu Asn Val Lys Ser   Ala Ala Asn 
    13640                 13645                 13650             


Leu Ile   Val Glu Glu Glu Asp   Leu Arg Ile Val Glu   Pro Leu Lys 
    13655                 13660                 13665             


Asp Ile   Glu Thr Met Glu Lys   Lys Ser Val Thr Phe   Trp Cys Lys 
    13670                 13675                 13680             


Val Asn   Arg Leu Asn Val Thr   Leu Lys Trp Thr Lys   Asn Gly Glu 
    13685                 13690                 13695             


Glu Val   Pro Phe Asp Asn Arg   Val Ser Tyr Arg Val   Asp Lys Tyr 
    13700                 13705                 13710             


Lys His   Met Leu Thr Ile Lys   Asp Cys Gly Phe Pro   Asp Glu Gly 
    13715                 13720                 13725             


Glu Tyr   Ile Val Thr Ala Gly   Gln Asp Lys Ser Val   Ala Glu Leu 
    13730                 13735                 13740             


Leu Ile   Ile Glu Ala Pro Thr   Glu Phe Val Glu His   Leu Glu Asp 
    13745                 13750                 13755             


Gln Thr   Val Thr Glu Phe Asp   Asp Ala Val Phe Ser   Cys Gln Leu 
    13760                 13765                 13770             


Ser Arg   Glu Lys Ala Asn Val   Lys Trp Tyr Arg Asn   Gly Arg Glu 
    13775                 13780                 13785             


Ile Lys   Glu Gly Lys Lys Tyr   Lys Phe Glu Lys Asp   Gly Ser Ile 
    13790                 13795                 13800             


His Arg   Leu Ile Ile Lys Asp   Cys Arg Leu Asp Asp   Glu Cys Glu 
    13805                 13810                 13815             


Tyr Ala   Cys Gly Val Glu Asp   Arg Lys Ser Arg Ala   Arg Leu Phe 
    13820                 13825                 13830             


Val Glu   Glu Ile Pro Val Glu   Ile Ile Arg Pro Pro   Gln Asp Ile 
    13835                 13840                 13845             


Leu Glu   Ala Pro Gly Ala Asp   Val Val Phe Leu Ala   Glu Leu Asn 
    13850                 13855                 13860             


Lys Asp   Lys Val Glu Val Gln   Trp Leu Arg Asn Asn   Met Val Val 
    13865                 13870                 13875             


Val Gln   Gly Asp Lys His Gln   Met Met Ser Glu Gly   Lys Ile His 
    13880                 13885                 13890             


Arg Leu   Gln Ile Cys Asp Ile   Lys Pro Arg Asp Gln   Gly Glu Tyr 
    13895                 13900                 13905             


Arg Phe   Ile Ala Lys Asp Lys   Glu Ala Arg Ala Lys   Leu Glu Leu 
    13910                 13915                 13920             


Ala Ala   Ala Pro Lys Ile Lys   Thr Ala Asp Gln Asp   Leu Val Val 
    13925                 13930                 13935             


Asp Val   Gly Lys Pro Leu Thr   Met Val Val Pro Tyr   Asp Ala Tyr 
    13940                 13945                 13950             


Pro Lys   Ala Glu Ala Glu Trp   Phe Lys Glu Asn Glu   Pro Leu Ser 
    13955                 13960                 13965             


Thr Lys   Thr Ile Asp Thr Thr   Ala Glu Gln Thr Ser   Phe Arg Ile 
    13970                 13975                 13980             


Leu Glu   Ala Lys Lys Gly Asp   Lys Gly Arg Tyr Lys   Ile Val Leu 
    13985                 13990                 13995             


Gln Asn   Lys His Gly Lys Ala   Glu Gly Phe Ile Asn   Leu Lys Val 
    14000                 14005                 14010             


Ile Asp   Val Pro Gly Pro Val   Arg Asn Leu Glu Val   Thr Glu Thr 
    14015                 14020                 14025             


Phe Asp   Gly Glu Val Ser Leu   Ala Trp Glu Glu Pro   Leu Thr Asp 
    14030                 14035                 14040             


Gly Gly   Ser Lys Ile Ile Gly   Tyr Val Val Glu Arg   Arg Asp Ile 
    14045                 14050                 14055             


Lys Arg   Lys Thr Trp Val Leu   Ala Thr Asp Arg Ala   Glu Ser Cys 
    14060                 14065                 14070             


Glu Phe   Thr Val Thr Gly Leu   Gln Lys Gly Gly Val   Glu Tyr Leu 
    14075                 14080                 14085             


Phe Arg   Val Ser Ala Arg Asn   Arg Val Gly Thr Gly   Glu Pro Val 
    14090                 14095                 14100             


Glu Thr   Asp Asn Pro Val Glu   Ala Arg Ser Lys Tyr   Asp Val Pro 
    14105                 14110                 14115             


Gly Pro   Pro Leu Asn Val Thr   Ile Thr Asp Val Asn   Arg Phe Gly 
    14120                 14125                 14130             


Val Ser   Leu Thr Trp Glu Pro   Pro Glu Tyr Asp Gly   Gly Ala Glu 
    14135                 14140                 14145             


Ile Thr   Asn Tyr Val Ile Glu   Leu Arg Asp Lys Thr   Ser Ile Arg 
    14150                 14155                 14160             


Trp Asp   Thr Ala Met Thr Val   Arg Ala Glu Asp Leu   Ser Ala Thr 
    14165                 14170                 14175             


Val Thr   Asp Val Val Glu Gly   Gln Glu Tyr Ser Phe   Arg Val Arg 
    14180                 14185                 14190             


Ala Gln   Asn Arg Ile Gly Val   Gly Lys Pro Ser Ala   Ala Thr Pro 
    14195                 14200                 14205             


Phe Val   Lys Val Ala Asp Pro   Ile Glu Arg Pro Ser   Pro Pro Val 
    14210                 14215                 14220             


Asn Leu   Thr Ser Ser Asp Gln   Thr Gln Ser Ser Val   Gln Leu Lys 
    14225                 14230                 14235             


Trp Glu   Pro Pro Leu Lys Asp   Gly Gly Ser Pro Ile   Leu Gly Tyr 
    14240                 14245                 14250             


Ile Ile   Glu Arg Cys Glu Glu   Gly Lys Asp Asn Trp   Ile Arg Cys 
    14255                 14260                 14265             


Asn Met   Lys Leu Val Pro Glu   Leu Thr Tyr Lys Val   Thr Gly Leu 
    14270                 14275                 14280             


Glu Lys   Gly Asn Lys Tyr Leu   Tyr Arg Val Ser Ala   Glu Asn Lys 
    14285                 14290                 14295             


Ala Gly   Val Ser Asp Pro Ser   Glu Ile Leu Gly Pro   Leu Thr Ala 
    14300                 14305                 14310             


Asp Asp   Ala Phe Val Glu Pro   Thr Met Asp Leu Ser   Ala Phe Lys 
    14315                 14320                 14325             


Asp Gly   Leu Glu Val Ile Val   Pro Asn Pro Ile Thr   Ile Leu Val 
    14330                 14335                 14340             


Pro Ser   Thr Gly Tyr Pro Arg   Pro Thr Ala Thr Trp   Cys Phe Gly 
    14345                 14350                 14355             


Asp Lys   Val Leu Glu Thr Gly   Asp Arg Val Lys Met   Lys Thr Leu 
    14360                 14365                 14370             


Ser Ala   Tyr Ala Glu Leu Val   Ile Ser Pro Ser Glu   Arg Ser Asp 
    14375                 14380                 14385             


Lys Gly   Ile Tyr Thr Leu Lys   Leu Glu Asn Arg Val   Lys Thr Ile 
    14390                 14395                 14400             


Ser Gly   Glu Ile Asp Val Asn   Val Ile Ala Arg Pro   Ser Ala Pro 
    14405                 14410                 14415             


Lys Glu   Leu Lys Phe Gly Asp   Ile Thr Lys Asp Ser   Val His Leu 
    14420                 14425                 14430             


Thr Trp   Glu Pro Pro Asp Asp   Asp Gly Gly Ser Pro   Leu Thr Gly 
    14435                 14440                 14445             


Tyr Val   Val Glu Lys Arg Glu   Val Ser Arg Lys Thr   Trp Thr Lys 
    14450                 14455                 14460             


Val Met   Asp Phe Val Thr Asp   Leu Glu Phe Thr Val   Pro Asp Leu 
    14465                 14470                 14475             


Val Gln   Gly Lys Glu Tyr Leu   Phe Lys Val Cys Ala   Arg Asn Lys 
    14480                 14485                 14490             


Cys Gly   Pro Gly Glu Pro Ala   Tyr Val Asp Glu Pro   Val Asn Met 
    14495                 14500                 14505             


Ser Thr   Pro Ala Thr Val Pro   Asp Pro Pro Glu Asn   Val Lys Trp 
    14510                 14515                 14520             


Arg Asp   Arg Thr Ala Asn Ser   Ile Phe Leu Thr Trp   Asp Pro Pro 
    14525                 14530                 14535             


Lys Asn   Asp Gly Gly Ser Arg   Ile Lys Gly Tyr Ile   Val Glu Arg 
    14540                 14545                 14550             


Cys Pro   Arg Gly Ser Asp Lys   Trp Val Ala Cys Gly   Glu Pro Val 
    14555                 14560                 14565             


Ala Glu   Thr Lys Met Glu Val   Thr Gly Leu Glu Glu   Gly Lys Trp 
    14570                 14575                 14580             


Tyr Ala   Tyr Arg Val Lys Ala   Leu Asn Arg Gln Gly   Ala Ser Lys 
    14585                 14590                 14595             


Pro Ser   Arg Pro Thr Glu Glu   Ile Gln Ala Val Asp   Thr Gln Glu 
    14600                 14605                 14610             


Ala Pro   Glu Ile Phe Leu Asp   Val Lys Leu Leu Ala   Gly Leu Thr 
    14615                 14620                 14625             


Val Lys   Ala Gly Thr Lys Ile   Glu Leu Pro Ala Thr   Val Thr Gly 
    14630                 14635                 14640             


Lys Pro   Glu Pro Lys Ile Thr   Trp Thr Lys Ala Asp   Met Ile Leu 
    14645                 14650                 14655             


Lys Gln   Asp Lys Arg Ile Thr   Ile Glu Asn Val Pro   Lys Lys Ser 
    14660                 14665                 14670             


Thr Val   Thr Ile Val Asp Ser   Lys Arg Ser Asp Thr   Gly Thr Tyr 
    14675                 14680                 14685             


Ile Ile   Glu Ala Val Asn Val   Cys Gly Arg Ala Thr   Ala Val Val 
    14690                 14695                 14700             


Glu Val   Asn Val Leu Asp Lys   Pro Gly Pro Pro Ala   Ala Phe Asp 
    14705                 14710                 14715             


Ile Thr   Asp Val Thr Asn Glu   Ser Cys Leu Leu Thr   Trp Asn Pro 
    14720                 14725                 14730             


Pro Arg   Asp Asp Gly Gly Ser   Lys Ile Thr Asn Tyr   Val Val Glu 
    14735                 14740                 14745             


Arg Arg   Ala Thr Asp Ser Glu   Val Trp His Lys Leu   Ser Ser Thr 
    14750                 14755                 14760             


Val Lys   Asp Thr Asn Phe Lys   Ala Thr Lys Leu Ile   Pro Asn Lys 
    14765                 14770                 14775             


Glu Tyr   Ile Phe Arg Val Ala   Ala Glu Asn Met Tyr   Gly Val Gly 
    14780                 14785                 14790             


Glu Pro   Val Gln Ala Ser Pro   Ile Thr Ala Lys Tyr   Gln Phe Asp 
    14795                 14800                 14805             


Pro Pro   Gly Pro Pro Thr Arg   Leu Glu Pro Ser Asp   Ile Thr Lys 
    14810                 14815                 14820             


Asp Ala   Val Thr Leu Thr Trp   Cys Glu Pro Asp Asp   Asp Gly Gly 
    14825                 14830                 14835             


Ser Pro   Ile Thr Gly Tyr Trp   Val Glu Arg Leu Asp   Pro Asp Thr 
    14840                 14845                 14850             


Asp Lys   Trp Val Arg Cys Asn   Lys Met Pro Val Lys   Asp Thr Thr 
    14855                 14860                 14865             


Tyr Arg   Val Lys Gly Leu Thr   Asn Lys Lys Lys Tyr   Arg Phe Arg 
    14870                 14875                 14880             


Val Leu   Ala Glu Asn Leu Ala   Gly Pro Gly Lys Pro   Ser Lys Ser 
    14885                 14890                 14895             


Thr Glu   Pro Ile Leu Ile Lys   Asp Pro Ile Asp Pro   Pro Trp Pro 
    14900                 14905                 14910             


Pro Gly   Lys Pro Thr Val Lys   Asp Val Gly Lys Thr   Ser Val Arg 
    14915                 14920                 14925             


Leu Asn   Trp Thr Lys Pro Glu   His Asp Gly Gly Ala   Lys Ile Glu 
    14930                 14935                 14940             


Ser Tyr   Val Ile Glu Met Leu   Lys Thr Gly Thr Asp   Glu Trp Val 
    14945                 14950                 14955             


Arg Val   Ala Glu Gly Val Pro   Thr Thr Gln His Leu   Leu Pro Gly 
    14960                 14965                 14970             


Leu Met   Glu Gly Gln Glu Tyr   Ser Phe Arg Val Arg   Ala Val Asn 
    14975                 14980                 14985             


Lys Ala   Gly Glu Ser Glu Pro   Ser Glu Pro Ser Asp   Pro Val Leu 
    14990                 14995                 15000             


Cys Arg   Glu Lys Leu Tyr Pro   Pro Ser Pro Pro Arg   Trp Leu Glu 
    15005                 15010                 15015             


Val Ile   Asn Ile Thr Lys Asn   Thr Ala Asp Leu Lys   Trp Thr Val 
    15020                 15025                 15030             


Pro Glu   Lys Asp Gly Gly Ser   Pro Ile Thr Asn Tyr   Ile Val Glu 
    15035                 15040                 15045             


Lys Arg   Asp Val Arg Arg Lys   Gly Trp Gln Thr Val   Asp Thr Thr 
    15050                 15055                 15060             


Val Lys   Asp Thr Lys Cys Thr   Val Thr Pro Leu Thr   Glu Gly Ser 
    15065                 15070                 15075             


Leu Tyr   Val Phe Arg Val Ala   Ala Glu Asn Ala Ile   Gly Gln Ser 
    15080                 15085                 15090             


Asp Tyr   Thr Glu Ile Glu Asp   Ser Val Leu Ala Lys   Asp Thr Phe 
    15095                 15100                 15105             


Thr Thr   Pro Gly Pro Pro Tyr   Ala Leu Ala Val Val   Asp Val Thr 
    15110                 15115                 15120             


Lys Arg   His Val Asp Leu Lys   Trp Glu Pro Pro Lys   Asn Asp Gly 
    15125                 15130                 15135             


Gly Arg   Pro Ile Gln Arg Tyr   Val Ile Glu Lys Lys   Glu Arg Leu 
    15140                 15145                 15150             


Gly Thr   Arg Trp Val Lys Ala   Gly Lys Thr Ala Gly   Pro Asp Cys 
    15155                 15160                 15165             


Asn Phe   Arg Val Thr Asp Val   Ile Glu Gly Thr Glu   Val Gln Phe 
    15170                 15175                 15180             


Gln Val   Arg Ala Glu Asn Glu   Ala Gly Val Gly His   Pro Ser Glu 
    15185                 15190                 15195             


Pro Thr   Glu Ile Leu Ser Ile   Glu Asp Pro Thr Ser   Pro Pro Ser 
    15200                 15205                 15210             


Pro Pro   Leu Asp Leu His Val   Thr Asp Ala Gly Arg   Lys His Ile 
    15215                 15220                 15225             


Ala Ile   Ala Trp Lys Pro Pro   Glu Lys Asn Gly Gly   Ser Pro Ile 
    15230                 15235                 15240             


Ile Gly   Tyr His Val Glu Met   Cys Pro Val Gly Thr   Glu Lys Trp 
    15245                 15250                 15255             


Met Arg   Val Asn Ser Arg Pro   Ile Lys Asp Leu Lys   Phe Lys Val 
    15260                 15265                 15270             


Glu Glu   Gly Val Val Pro Asp   Lys Glu Tyr Val Leu   Arg Val Arg 
    15275                 15280                 15285             


Ala Val   Asn Ala Ile Gly Val   Ser Glu Pro Ser Glu   Ile Ser Glu 
    15290                 15295                 15300             


Asn Val   Val Ala Lys Asp Pro   Asp Cys Lys Pro Thr   Ile Asp Leu 
    15305                 15310                 15315             


Glu Thr   His Asp Ile Ile Val   Ile Glu Gly Glu Lys   Leu Ser Ile 
    15320                 15325                 15330             


Pro Val   Pro Phe Arg Ala Val   Pro Val Pro Thr Val   Ser Trp His 
    15335                 15340                 15345             


Lys Asp   Gly Lys Glu Val Lys   Ala Ser Asp Arg Leu   Thr Met Lys 
    15350                 15355                 15360             


Asn Asp   His Ile Ser Ala His   Leu Glu Val Pro Lys   Ser Val Arg 
    15365                 15370                 15375             


Ala Asp   Ala Gly Ile Tyr Thr   Ile Thr Leu Glu Asn   Lys Leu Gly 
    15380                 15385                 15390             


Ser Ala   Thr Ala Ser Ile Asn   Val Lys Val Ile Gly   Leu Pro Gly 
    15395                 15400                 15405             


Pro Cys   Lys Asp Ile Lys Ala   Ser Asp Ile Thr Lys   Ser Ser Cys 
    15410                 15415                 15420             


Lys Leu   Thr Trp Glu Pro Pro   Glu Phe Asp Gly Gly   Thr Pro Ile 
    15425                 15430                 15435             


Leu His   Tyr Val Leu Glu Arg   Arg Glu Ala Gly Arg   Arg Thr Tyr 
    15440                 15445                 15450             


Ile Pro   Val Met Ser Gly Glu   Asn Lys Leu Ser Trp   Thr Val Lys 
    15455                 15460                 15465             


Asp Leu   Ile Pro Asn Gly Glu   Tyr Phe Phe Arg Val   Lys Ala Val 
    15470                 15475                 15480             


Asn Lys   Val Gly Gly Gly Glu   Tyr Ile Glu Leu Lys   Asn Pro Val 
    15485                 15490                 15495             


Ile Ala   Gln Asp Pro Lys Gln   Pro Pro Asp Pro Pro   Val Asp Val 
    15500                 15505                 15510             


Glu Val   His Asn Pro Thr Ala   Glu Ala Met Thr Ile   Thr Trp Lys 
    15515                 15520                 15525             


Pro Pro   Leu Tyr Asp Gly Gly   Ser Lys Ile Met Gly   Tyr Ile Ile 
    15530                 15535                 15540             


Glu Lys   Ile Ala Lys Gly Glu   Glu Arg Trp Lys Arg   Cys Asn Glu 
    15545                 15550                 15555             


His Leu   Val Pro Ile Leu Thr   Tyr Thr Ala Lys Gly   Leu Glu Glu 
    15560                 15565                 15570             


Gly Lys   Glu Tyr Gln Phe Arg   Val Arg Ala Glu Asn   Ala Ala Gly 
    15575                 15580                 15585             


Ile Ser   Glu Pro Ser Arg Ala   Thr Pro Pro Thr Lys   Ala Val Asp 
    15590                 15595                 15600             


Pro Ile   Asp Ala Pro Lys Val   Ile Leu Arg Thr Ser   Leu Glu Val 
    15605                 15610                 15615             


Lys Arg   Gly Asp Glu Ile Ala   Leu Asp Ala Ser Ile   Ser Gly Ser 
    15620                 15625                 15630             


Pro Tyr   Pro Thr Ile Thr Trp   Ile Lys Asp Glu Asn   Val Ile Val 
    15635                 15640                 15645             


Pro Glu   Glu Ile Lys Lys Arg   Ala Ala Pro Leu Val   Arg Arg Arg 
    15650                 15655                 15660             


Lys Gly   Glu Val Gln Glu Glu   Glu Pro Phe Val Leu   Pro Leu Thr 
    15665                 15670                 15675             


Gln Arg   Leu Ser Ile Asp Asn   Ser Lys Lys Gly Glu   Ser Gln Leu 
    15680                 15685                 15690             


Arg Val   Arg Asp Ser Leu Arg   Pro Asp His Gly Leu   Tyr Met Ile 
    15695                 15700                 15705             


Lys Val   Glu Asn Asp His Gly   Ile Ala Lys Ala Pro   Cys Thr Val 
    15710                 15715                 15720             


Ser Val   Leu Asp Thr Pro Gly   Pro Pro Ile Asn Phe   Val Phe Glu 
    15725                 15730                 15735             


Asp Ile   Arg Lys Thr Ser Val   Leu Cys Lys Trp Glu   Pro Pro Leu 
    15740                 15745                 15750             


Asp Asp   Gly Gly Ser Glu Ile   Ile Asn Tyr Thr Leu   Glu Lys Lys 
    15755                 15760                 15765             


Asp Lys   Thr Lys Pro Asp Ser   Glu Trp Ile Val Val   Thr Ser Thr 
    15770                 15775                 15780             


Leu Arg   His Cys Lys Tyr Ser   Val Thr Lys Leu Ile   Glu Gly Lys 
    15785                 15790                 15795             


Glu Tyr   Leu Phe Arg Val Arg   Ala Glu Asn Arg Phe   Gly Pro Gly 
    15800                 15805                 15810             


Pro Pro   Cys Val Ser Lys Pro   Leu Val Ala Lys Asp   Pro Phe Gly 
    15815                 15820                 15825             


Pro Pro   Asp Ala Pro Asp Lys   Pro Ile Val Glu Asp   Val Thr Ser 
    15830                 15835                 15840             


Asn Ser   Met Leu Val Lys Trp   Asn Glu Pro Lys Asp   Asn Gly Ser 
    15845                 15850                 15855             


Pro Ile   Leu Gly Tyr Trp Leu   Glu Lys Arg Glu Val   Asn Ser Thr 
    15860                 15865                 15870             


His Trp   Ser Arg Val Asn Lys   Ser Leu Leu Asn Ala   Leu Lys Ala 
    15875                 15880                 15885             


Asn Val   Asp Gly Leu Leu Glu   Gly Leu Thr Tyr Val   Phe Arg Val 
    15890                 15895                 15900             


Cys Ala   Glu Asn Ala Ala Gly   Pro Gly Lys Phe Ser   Pro Pro Ser 
    15905                 15910                 15915             


Asp Pro   Lys Thr Ala His Asp   Pro Ile Ser Pro Pro   Gly Pro Pro 
    15920                 15925                 15930             


Ile Pro   Arg Val Thr Asp Thr   Ser Ser Thr Thr Ile   Glu Leu Glu 
    15935                 15940                 15945             


Trp Glu   Pro Pro Ala Phe Asn   Gly Gly Gly Glu Ile   Val Gly Tyr 
    15950                 15955                 15960             


Phe Val   Asp Lys Gln Leu Val   Gly Thr Asn Glu Trp   Ser Arg Cys 
    15965                 15970                 15975             


Thr Glu   Lys Met Ile Lys Val   Arg Gln Tyr Thr Val   Lys Glu Ile 
    15980                 15985                 15990             


Arg Glu   Gly Ala Asp Tyr Lys   Leu Arg Val Ser Ala   Val Asn Ala 
    15995                 16000                 16005             


Ala Gly   Glu Gly Pro Pro Gly   Glu Thr Gln Pro Val   Thr Val Ala 
    16010                 16015                 16020             


Glu Pro   Gln Glu Pro Pro Ala   Val Glu Leu Asp Val   Ser Val Lys 
    16025                 16030                 16035             


Gly Gly   Ile Gln Ile Met Ala   Gly Lys Thr Leu Arg   Ile Pro Ala 
    16040                 16045                 16050             


Val Val   Thr Gly Arg Pro Val   Pro Thr Lys Val Trp   Thr Lys Glu 
    16055                 16060                 16065             


Glu Gly   Glu Leu Asp Lys Asp   Arg Val Val Ile Asp   Asn Val Gly 
    16070                 16075                 16080             


Thr Lys   Ser Glu Leu Ile Ile   Lys Asp Ala Leu Arg   Lys Asp His 
    16085                 16090                 16095             


Gly Arg   Tyr Val Ile Thr Ala   Thr Asn Ser Cys Gly   Ser Lys Phe 
    16100                 16105                 16110             


Ala Ala   Ala Arg Val Glu Val   Phe Asp Val Pro Gly   Pro Val Leu 
    16115                 16120                 16125             


Asp Leu   Lys Pro Val Val Thr   Asn Arg Lys Met Cys   Leu Leu Asn 
    16130                 16135                 16140             


Trp Ser   Asp Pro Glu Asp Asp   Gly Gly Ser Glu Ile   Thr Gly Phe 
    16145                 16150                 16155             


Ile Ile   Glu Arg Lys Asp Ala   Lys Met His Thr Trp   Arg Gln Pro 
    16160                 16165                 16170             


Ile Glu   Thr Glu Arg Ser Lys   Cys Asp Ile Thr Gly   Leu Leu Glu 
    16175                 16180                 16185             


Gly Gln   Glu Tyr Lys Phe Arg   Val Ile Ala Lys Asn   Lys Phe Gly 
    16190                 16195                 16200             


Cys Gly   Pro Pro Val Glu Ile   Gly Pro Ile Leu Ala   Val Asp Pro 
    16205                 16210                 16215             


Leu Gly   Pro Pro Thr Ser Pro   Glu Arg Leu Thr Tyr   Thr Glu Arg 
    16220                 16225                 16230             


Thr Lys   Ser Thr Ile Thr Leu   Asp Trp Lys Glu Pro   Arg Ser Asn 
    16235                 16240                 16245             


Gly Gly   Ser Pro Ile Gln Gly   Tyr Ile Ile Glu Lys   Arg Arg His 
    16250                 16255                 16260             


Asp Lys   Pro Asp Phe Glu Arg   Val Asn Lys Arg Leu   Cys Pro Thr 
    16265                 16270                 16275             


Thr Ser   Phe Leu Val Glu Asn   Leu Asp Glu His Gln   Met Tyr Glu 
    16280                 16285                 16290             


Phe Arg   Val Lys Ala Val Asn   Glu Ile Gly Glu Ser   Glu Pro Ser 
    16295                 16300                 16305             


Leu Pro   Leu Asn Val Val Ile   Gln Asp Asp Glu Val   Pro Pro Thr 
    16310                 16315                 16320             


Ile Lys   Leu Arg Leu Ser Val   Arg Gly Asp Thr Ile   Lys Val Lys 
    16325                 16330                 16335             


Ala Gly   Glu Pro Val His Ile   Pro Ala Asp Val Thr   Gly Leu Pro 
    16340                 16345                 16350             


Met Pro   Lys Ile Glu Trp Ser   Lys Asn Glu Thr Val   Ile Glu Lys 
    16355                 16360                 16365             


Pro Thr   Asp Ala Leu Gln Ile   Thr Lys Glu Glu Val   Ser Arg Ser 
    16370                 16375                 16380             


Glu Ala   Lys Thr Glu Leu Ser   Ile Pro Lys Ala Val   Arg Glu Asp 
    16385                 16390                 16395             


Lys Gly   Thr Tyr Thr Val Thr   Ala Ser Asn Arg Leu   Gly Ser Val 
    16400                 16405                 16410             


Phe Arg   Asn Val His Val Glu   Val Tyr Asp Arg Pro   Ser Pro Pro 
    16415                 16420                 16425             


Arg Asn   Leu Ala Val Thr Asp   Ile Lys Ala Glu Ser   Cys Tyr Leu 
    16430                 16435                 16440             


Thr Trp   Asp Ala Pro Leu Asp   Asn Gly Gly Ser Glu   Ile Thr His 
    16445                 16450                 16455             


Tyr Val   Ile Asp Lys Arg Asp   Ala Ser Arg Lys Lys   Ala Glu Trp 
    16460                 16465                 16470             


Glu Glu   Val Thr Asn Thr Ala   Val Glu Lys Arg Tyr   Gly Ile Trp 
    16475                 16480                 16485             


Lys Leu   Ile Pro Asn Gly Gln   Tyr Glu Phe Arg Val   Arg Ala Val 
    16490                 16495                 16500             


Asn Lys   Tyr Gly Ile Ser Asp   Glu Cys Lys Ser Asp   Lys Val Val 
    16505                 16510                 16515             


Ile Gln   Asp Pro Tyr Arg Leu   Pro Gly Pro Pro Gly   Lys Pro Lys 
    16520                 16525                 16530             


Val Leu   Ala Arg Thr Lys Gly   Ser Met Leu Val Ser   Trp Thr Pro 
    16535                 16540                 16545             


Pro Leu   Asp Asn Gly Gly Ser   Pro Ile Thr Gly Tyr   Trp Leu Glu 
    16550                 16555                 16560             


Lys Arg   Glu Glu Gly Ser Pro   Tyr Trp Ser Arg Val   Ser Arg Ala 
    16565                 16570                 16575             


Pro Ile   Thr Lys Val Gly Leu   Lys Gly Val Glu Phe   Asn Val Pro 
    16580                 16585                 16590             


Arg Leu   Leu Glu Gly Val Lys   Tyr Gln Phe Arg Ala   Met Ala Ile 
    16595                 16600                 16605             


Asn Ala   Ala Gly Ile Gly Pro   Pro Ser Glu Pro Ser   Asp Pro Glu 
    16610                 16615                 16620             


Val Ala   Gly Asp Pro Ile Phe   Pro Pro Gly Pro Pro   Ser Cys Pro 
    16625                 16630                 16635             


Glu Val   Lys Asp Lys Thr Lys   Ser Ser Ile Ser Leu   Gly Trp Lys 
    16640                 16645                 16650             


Pro Pro   Ala Lys Asp Gly Gly   Ser Pro Ile Lys Gly   Tyr Ile Val 
    16655                 16660                 16665             


Glu Met   Gln Glu Glu Gly Thr   Thr Asp Trp Lys Arg   Val Asn Glu 
    16670                 16675                 16680             


Pro Asp   Lys Leu Ile Thr Thr   Cys Glu Cys Val Val   Pro Asn Leu 
    16685                 16690                 16695             


Lys Glu   Leu Arg Lys Tyr Arg   Phe Arg Val Lys Ala   Val Asn Glu 
    16700                 16705                 16710             


Ala Gly   Glu Ser Glu Pro Ser   Asp Thr Thr Gly Glu   Ile Pro Ala 
    16715                 16720                 16725             


Thr Asp   Ile Gln Glu Glu Pro   Glu Val Phe Ile Asp   Ile Gly Ala 
    16730                 16735                 16740             


Gln Asp   Cys Leu Val Cys Lys   Ala Gly Ser Gln Ile   Arg Ile Pro 
    16745                 16750                 16755             


Ala Val   Ile Lys Gly Arg Pro   Thr Pro Lys Ser Ser   Trp Glu Phe 
    16760                 16765                 16770             


Asp Gly   Lys Ala Lys Lys Ala   Met Lys Asp Gly Val   His Asp Ile 
    16775                 16780                 16785             


Pro Glu   Asp Ala Gln Leu Glu   Thr Ala Glu Asn Ser   Ser Val Ile 
    16790                 16795                 16800             


Ile Ile   Pro Glu Cys Lys Arg   Ser His Thr Gly Lys   Tyr Ser Ile 
    16805                 16810                 16815             


Thr Ala   Lys Asn Lys Ala Gly   Gln Lys Thr Ala Asn   Cys Arg Val 
    16820                 16825                 16830             


Lys Val   Met Asp Val Pro Gly   Pro Pro Lys Asp Leu   Lys Val Ser 
    16835                 16840                 16845             


Asp Ile   Thr Arg Gly Ser Cys   Arg Leu Ser Trp Lys   Met Pro Asp 
    16850                 16855                 16860             


Asp Asp   Gly Gly Asp Arg Ile   Lys Gly Tyr Val Ile   Glu Lys Arg 
    16865                 16870                 16875             


Thr Ile   Asp Gly Lys Ala Trp   Thr Lys Val Asn Pro   Asp Cys Gly 
    16880                 16885                 16890             


Ser Thr   Thr Phe Val Val Pro   Asp Leu Leu Ser Glu   Gln Gln Tyr 
    16895                 16900                 16905             


Phe Phe   Arg Val Arg Ala Glu   Asn Arg Phe Gly Ile   Gly Pro Pro 
    16910                 16915                 16920             


Val Glu   Thr Ile Gln Arg Thr   Thr Ala Arg Asp Pro   Ile Tyr Pro 
    16925                 16930                 16935             


Pro Asp   Pro Pro Ile Lys Leu   Lys Ile Gly Leu Ile   Thr Lys Asn 
    16940                 16945                 16950             


Thr Val   His Leu Ser Trp Lys   Pro Pro Lys Asn Asp   Gly Gly Ser 
    16955                 16960                 16965             


Pro Val   Thr His Tyr Ile Val   Glu Cys Leu Ala Trp   Asp Pro Thr 
    16970                 16975                 16980             


Gly Thr   Lys Lys Glu Ala Trp   Arg Gln Cys Asn Lys   Arg Asp Val 
    16985                 16990                 16995             


Glu Glu   Leu Gln Phe Thr Val   Glu Asp Leu Val Glu   Gly Gly Glu 
    17000                 17005                 17010             


Tyr Glu   Phe Arg Val Lys Ala   Val Asn Ala Ala Gly   Val Ser Lys 
    17015                 17020                 17025             


Pro Ser   Ala Thr Val Gly Pro   Cys Asp Cys Gln Arg   Pro Asp Met 
    17030                 17035                 17040             


Pro Pro   Ser Ile Asp Leu Lys   Glu Phe Met Glu Val   Glu Glu Gly 
    17045                 17050                 17055             


Thr Asn   Val Asn Ile Val Ala   Lys Ile Lys Gly Val   Pro Phe Pro 
    17060                 17065                 17070             


Thr Leu   Thr Trp Phe Lys Ala   Pro Pro Lys Lys Pro   Asp Asn Lys 
    17075                 17080                 17085             


Glu Pro   Val Leu Tyr Asp Thr   His Val Asn Lys Leu   Val Val Asp 
    17090                 17095                 17100             


Asp Thr   Cys Thr Leu Val Ile   Pro Gln Ser Arg Arg   Ser Asp Thr 
    17105                 17110                 17115             


Gly Leu   Tyr Thr Ile Thr Ala   Val Asn Asn Leu Gly   Thr Ala Ser 
    17120                 17125                 17130             


Lys Glu   Met Arg Leu Asn Val   Leu Gly Arg Pro Gly   Pro Pro Val 
    17135                 17140                 17145             


Gly Pro   Ile Lys Phe Glu Ser   Val Ser Ala Asp Gln   Met Thr Leu 
    17150                 17155                 17160             


Ser Trp   Phe Pro Pro Lys Asp   Asp Gly Gly Ser Lys   Ile Thr Asn 
    17165                 17170                 17175             


Tyr Val   Ile Glu Lys Arg Glu   Ala Asn Arg Lys Thr   Trp Val His 
    17180                 17185                 17190             


Val Ser   Ser Glu Pro Lys Glu   Cys Thr Tyr Thr Ile   Pro Lys Leu 
    17195                 17200                 17205             


Leu Glu   Gly His Glu Tyr Val   Phe Arg Ile Met Ala   Gln Asn Lys 
    17210                 17215                 17220             


Tyr Gly   Ile Gly Glu Pro Leu   Asp Ser Glu Pro Glu   Thr Ala Arg 
    17225                 17230                 17235             


Asn Leu   Phe Ser Val Pro Gly   Ala Pro Asp Lys Pro   Thr Val Ser 
    17240                 17245                 17250             


Ser Val   Thr Arg Asn Ser Met   Thr Val Asn Trp Glu   Glu Pro Glu 
    17255                 17260                 17265             


Tyr Asp   Gly Gly Ser Pro Val   Thr Gly Tyr Trp Leu   Glu Met Lys 
    17270                 17275                 17280             


Asp Thr   Thr Ser Lys Arg Trp   Lys Arg Val Asn Arg   Asp Pro Ile 
    17285                 17290                 17295             


Lys Ala   Met Thr Leu Gly Val   Ser Tyr Lys Val Thr   Gly Leu Ile 
    17300                 17305                 17310             


Glu Gly   Ser Asp Tyr Gln Phe   Arg Val Tyr Ala Ile   Asn Ala Ala 
    17315                 17320                 17325             


Gly Val   Gly Pro Ala Ser Leu   Pro Ser Asp Pro Ala   Thr Ala Arg 
    17330                 17335                 17340             


Asp Pro   Ile Ala Pro Pro Gly   Pro Pro Phe Pro Lys   Val Thr Asp 
    17345                 17350                 17355             


Trp Thr   Lys Ser Ser Ala Asp   Leu Glu Trp Ser Pro   Pro Leu Lys 
    17360                 17365                 17370             


Asp Gly   Gly Ser Lys Val Thr   Gly Tyr Ile Val Glu   Tyr Lys Glu 
    17375                 17380                 17385             


Glu Gly   Lys Glu Glu Trp Glu   Lys Gly Lys Asp Lys   Glu Val Arg 
    17390                 17395                 17400             


Gly Thr   Lys Leu Val Val Thr   Gly Leu Lys Glu Gly   Ala Phe Tyr 
    17405                 17410                 17415             


Lys Phe   Arg Val Ser Ala Val   Asn Ile Ala Gly Ile   Gly Glu Pro 
    17420                 17425                 17430             


Gly Glu   Val Thr Asp Val Ile   Glu Met Lys Asp Arg   Leu Val Ser 
    17435                 17440                 17445             


Pro Asp   Leu Gln Leu Asp Ala   Ser Val Arg Asp Arg   Ile Val Val 
    17450                 17455                 17460             


His Ala   Gly Gly Val Ile Arg   Ile Ile Ala Tyr Val   Ser Gly Lys 
    17465                 17470                 17475             


Pro Pro   Pro Thr Val Thr Trp   Asn Met Asn Glu Arg   Thr Leu Pro 
    17480                 17485                 17490             


Gln Glu   Ala Thr Ile Glu Thr   Thr Ala Ile Ser Ser   Ser Met Val 
    17495                 17500                 17505             


Ile Lys   Asn Cys Gln Arg Ser   His Gln Gly Val Tyr   Ser Leu Leu 
    17510                 17515                 17520             


Ala Lys   Asn Glu Ala Gly Glu   Arg Lys Lys Thr Ile   Ile Val Asp 
    17525                 17530                 17535             


Val Leu   Asp Val Pro Gly Pro   Val Gly Thr Pro Phe   Leu Ala His 
    17540                 17545                 17550             


Asn Leu   Thr Asn Glu Ser Cys   Lys Leu Thr Trp Phe   Ser Pro Glu 
    17555                 17560                 17565             


Asp Asp   Gly Gly Ser Pro Ile   Thr Asn Tyr Val Ile   Glu Lys Arg 
    17570                 17575                 17580             


Glu Ser   Asp Arg Arg Ala Trp   Thr Pro Val Thr Tyr   Thr Val Thr 
    17585                 17590                 17595             


Arg Gln   Asn Ala Thr Val Gln   Gly Leu Ile Gln Gly   Lys Ala Tyr 
    17600                 17605                 17610             


Phe Phe   Arg Ile Ala Ala Glu   Asn Ser Ile Gly Met   Gly Pro Phe 
    17615                 17620                 17625             


Val Glu   Thr Ser Glu Ala Leu   Val Ile Arg Glu Pro   Ile Thr Val 
    17630                 17635                 17640             


Pro Glu   Arg Pro Glu Asp Leu   Glu Val Lys Glu Val   Thr Lys Asn 
    17645                 17650                 17655             


Thr Val   Thr Leu Thr Trp Asn   Pro Pro Lys Tyr Asp   Gly Gly Ser 
    17660                 17665                 17670             


Glu Ile   Ile Asn Tyr Val Leu   Glu Ser Arg Leu Ile   Gly Thr Glu 
    17675                 17680                 17685             


Lys Phe   His Lys Val Thr Asn   Asp Asn Leu Leu Ser   Arg Lys Tyr 
    17690                 17695                 17700             


Thr Val   Lys Gly Leu Lys Glu   Gly Asp Thr Tyr Glu   Tyr Arg Val 
    17705                 17710                 17715             


Ser Ala   Val Asn Ile Val Gly   Gln Gly Lys Pro Ser   Phe Cys Thr 
    17720                 17725                 17730             


Lys Pro   Ile Thr Cys Lys Asp   Glu Leu Ala Pro Pro   Thr Leu His 
    17735                 17740                 17745             


Leu Asp   Phe Arg Asp Lys Leu   Thr Ile Arg Val Gly   Glu Ala Phe 
    17750                 17755                 17760             


Ala Leu   Thr Gly Arg Tyr Ser   Gly Lys Pro Lys Pro   Lys Val Ser 
    17765                 17770                 17775             


Trp Phe   Lys Asp Glu Ala Asp   Val Leu Glu Asp Asp   Arg Thr His 
    17780                 17785                 17790             


Ile Lys   Thr Thr Pro Ala Thr   Leu Ala Leu Glu Lys   Ile Lys Ala 
    17795                 17800                 17805             


Lys Arg   Ser Asp Ser Gly Lys   Tyr Cys Val Val Val   Glu Asn Ser 
    17810                 17815                 17820             


Thr Gly   Ser Arg Lys Gly Phe   Cys Gln Val Asn Val   Val Asp Arg 
    17825                 17830                 17835             


Pro Gly   Pro Pro Val Gly Pro   Val Ser Phe Asp Glu   Val Thr Lys 
    17840                 17845                 17850             


Asp Tyr   Met Val Ile Ser Trp   Lys Pro Pro Leu Asp   Asp Gly Gly 
    17855                 17860                 17865             


Ser Lys   Ile Thr Asn Tyr Ile   Ile Glu Lys Lys Glu   Val Gly Lys 
    17870                 17875                 17880             


Asp Val   Trp Met Pro Val Thr   Ser Ala Ser Ala Lys   Thr Thr Cys 
    17885                 17890                 17895             


Lys Val   Ser Lys Leu Leu Glu   Gly Lys Asp Tyr Ile   Phe Arg Ile 
    17900                 17905                 17910             


His Ala   Glu Asn Leu Tyr Gly   Ile Ser Asp Pro Leu   Val Ser Asp 
    17915                 17920                 17925             


Ser Met   Lys Ala Lys Asp Arg   Phe Arg Val Pro Asp   Ala Pro Asp 
    17930                 17935                 17940             


Gln Pro   Ile Val Thr Glu Val   Thr Lys Asp Ser Ala   Leu Val Thr 
    17945                 17950                 17955             


Trp Asn   Lys Pro His Asp Gly   Gly Lys Pro Ile Thr   Asn Tyr Ile 
    17960                 17965                 17970             


Leu Glu   Lys Arg Glu Thr Met   Ser Lys Arg Trp Ala   Arg Val Thr 
    17975                 17980                 17985             


Lys Asp   Pro Ile His Pro Tyr   Thr Lys Phe Arg Val   Pro Asp Leu 
    17990                 17995                 18000             


Leu Glu   Gly Cys Gln Tyr Glu   Phe Arg Val Ser Ala   Glu Asn Glu 
    18005                 18010                 18015             


Ile Gly   Ile Gly Asp Pro Ser   Pro Pro Ser Lys Pro   Val Phe Ala 
    18020                 18025                 18030             


Lys Asp   Pro Ile Ala Lys Pro   Ser Pro Pro Val Asn   Pro Glu Ala 
    18035                 18040                 18045             


Ile Asp   Thr Thr Cys Asn Ser   Val Asp Leu Thr Trp   Gln Pro Pro 
    18050                 18055                 18060             


Arg His   Asp Gly Gly Ser Lys   Ile Leu Gly Tyr Ile   Val Glu Tyr 
    18065                 18070                 18075             


Gln Lys   Val Gly Asp Glu Glu   Trp Arg Arg Ala Asn   His Thr Pro 
    18080                 18085                 18090             


Glu Ser   Cys Pro Glu Thr Lys   Tyr Lys Val Thr Gly   Leu Arg Asp 
    18095                 18100                 18105             


Gly Gln   Thr Tyr Lys Phe Arg   Val Leu Ala Val Asn   Ala Ala Gly 
    18110                 18115                 18120             


Glu Ser   Asp Pro Ala His Val   Pro Glu Pro Val Leu   Val Lys Asp 
    18125                 18130                 18135             


Arg Leu   Glu Pro Pro Glu Leu   Ile Leu Asp Ala Asn   Met Ala Arg 
    18140                 18145                 18150             


Glu Gln   His Ile Lys Val Gly   Asp Thr Leu Arg Leu   Ser Ala Ile 
    18155                 18160                 18165             


Ile Lys   Gly Val Pro Phe Pro   Lys Val Thr Trp Lys   Lys Glu Asp 
    18170                 18175                 18180             


Arg Asp   Ala Pro Thr Lys Ala   Arg Ile Asp Val Thr   Pro Val Gly 
    18185                 18190                 18195             


Ser Lys   Leu Glu Ile Arg Asn   Ala Ala His Glu Asp   Gly Gly Ile 
    18200                 18205                 18210             


Tyr Ser   Leu Thr Val Glu Asn   Pro Ala Gly Ser Lys   Thr Val Ser 
    18215                 18220                 18225             


Val Lys   Val Leu Val Leu Asp   Lys Pro Gly Pro Pro   Arg Asp Leu 
    18230                 18235                 18240             


Glu Val   Ser Glu Ile Arg Lys   Asp Ser Cys Tyr Leu   Thr Trp Lys 
    18245                 18250                 18255             


Glu Pro   Leu Asp Asp Gly Gly   Ser Val Ile Thr Asn   Tyr Val Val 
    18260                 18265                 18270             


Glu Arg   Arg Asp Val Ala Ser   Ala Gln Trp Ser Pro   Leu Ser Ala 
    18275                 18280                 18285             


Thr Ser   Lys Lys Lys Ser His   Phe Ala Lys His Leu   Asn Glu Gly 
    18290                 18295                 18300             


Asn Gln   Tyr Leu Phe Arg Val   Ala Ala Glu Asn Gln   Tyr Gly Arg 
    18305                 18310                 18315             


Gly Pro   Phe Val Glu Thr Pro   Lys Pro Ile Lys Ala   Leu Asp Pro 
    18320                 18325                 18330             


Leu His   Pro Pro Gly Pro Pro   Lys Asp Leu His His   Val Asp Val 
    18335                 18340                 18345             


Asp Lys   Thr Glu Val Ser Leu   Val Trp Asn Lys Pro   Asp Arg Asp 
    18350                 18355                 18360             


Gly Gly   Ser Pro Ile Thr Gly   Tyr Leu Val Glu Tyr   Gln Glu Glu 
    18365                 18370                 18375             


Gly Thr   Gln Asp Trp Ile Lys   Phe Lys Thr Val Thr   Asn Leu Glu 
    18380                 18385                 18390             


Cys Val   Val Thr Gly Leu Gln   Gln Gly Lys Thr Tyr   Arg Phe Arg 
    18395                 18400                 18405             


Val Lys   Ala Glu Asn Ile Val   Gly Leu Gly Leu Pro   Asp Thr Thr 
    18410                 18415                 18420             


Ile Pro   Ile Glu Cys Gln Glu   Lys Leu Val Pro Pro   Ser Val Glu 
    18425                 18430                 18435             


Leu Asp   Val Lys Leu Ile Glu   Gly Leu Val Val Lys   Ala Gly Thr 
    18440                 18445                 18450             


Thr Val   Arg Phe Pro Ala Ile   Ile Arg Gly Val Pro   Val Pro Thr 
    18455                 18460                 18465             


Ala Lys   Trp Thr Thr Asp Gly   Ser Glu Ile Lys Thr   Asp Glu His 
    18470                 18475                 18480             


Tyr Thr   Val Glu Thr Asp Asn   Phe Ser Ser Val Leu   Thr Ile Lys 
    18485                 18490                 18495             


Asn Cys   Leu Arg Arg Asp Thr   Gly Glu Tyr Gln Ile   Thr Val Ser 
    18500                 18505                 18510             


Asn Ala   Ala Gly Ser Lys Thr   Val Ala Val His Leu   Thr Val Leu 
    18515                 18520                 18525             


Asp Val   Pro Gly Pro Pro Thr   Gly Pro Ile Asn Ile   Leu Asp Val 
    18530                 18535                 18540             


Thr Pro   Glu His Met Thr Ile   Ser Trp Gln Pro Pro   Lys Asp Asp 
    18545                 18550                 18555             


Gly Gly   Ser Pro Val Ile Asn   Tyr Ile Val Glu Lys   Gln Asp Thr 
    18560                 18565                 18570             


Arg Lys   Asp Thr Trp Gly Val   Val Ser Ser Gly Ser   Ser Lys Thr 
    18575                 18580                 18585             


Lys Leu   Lys Ile Pro His Leu   Gln Lys Gly Cys Glu   Tyr Val Phe 
    18590                 18595                 18600             


Arg Val   Arg Ala Glu Asn Lys   Ile Gly Val Gly Pro   Pro Leu Asp 
    18605                 18610                 18615             


Ser Thr   Pro Thr Val Ala Lys   His Lys Phe Ser Pro   Pro Ser Pro 
    18620                 18625                 18630             


Pro Gly   Lys Pro Val Val Thr   Asp Ile Thr Glu Asn   Ala Ala Thr 
    18635                 18640                 18645             


Val Ser   Trp Thr Leu Pro Lys   Ser Asp Gly Gly Ser   Pro Ile Thr 
    18650                 18655                 18660             


Gly Tyr   Tyr Met Glu Arg Arg   Glu Val Thr Gly Lys   Trp Val Arg 
    18665                 18670                 18675             


Val Asn   Lys Thr Pro Ile Ala   Asp Leu Lys Phe Arg   Val Thr Gly 
    18680                 18685                 18690             


Leu Tyr   Glu Gly Asn Thr Tyr   Glu Phe Arg Val Phe   Ala Glu Asn 
    18695                 18700                 18705             


Leu Ala   Gly Leu Ser Lys Pro   Ser Pro Ser Ser Asp   Pro Ile Lys 
    18710                 18715                 18720             


Ala Cys   Arg Pro Ile Lys Pro   Pro Gly Pro Pro Ile   Asn Pro Lys 
    18725                 18730                 18735             


Leu Lys   Asp Lys Ser Arg Glu   Thr Ala Asp Leu Val   Trp Thr Lys 
    18740                 18745                 18750             


Pro Leu   Ser Asp Gly Gly Ser   Pro Ile Leu Gly Tyr   Val Val Glu 
    18755                 18760                 18765             


Cys Gln   Lys Pro Gly Thr Ala   Gln Trp Asn Arg Ile   Asn Lys Asp 
    18770                 18775                 18780             


Glu Leu   Ile Arg Gln Cys Ala   Phe Arg Val Pro Gly   Leu Ile Glu 
    18785                 18790                 18795             


Gly Asn   Glu Tyr Arg Phe Arg   Ile Lys Ala Ala Asn   Ile Val Gly 
    18800                 18805                 18810             


Glu Gly   Glu Pro Arg Glu Leu   Ala Glu Ser Val Ile   Ala Lys Asp 
    18815                 18820                 18825             


Ile Leu   His Pro Pro Glu Val   Glu Leu Asp Val Thr   Cys Arg Asp 
    18830                 18835                 18840             


Val Ile   Thr Val Arg Val Gly   Gln Thr Ile Arg Ile   Leu Ala Arg 
    18845                 18850                 18855             


Val Lys   Gly Arg Pro Glu Pro   Asp Ile Thr Trp Thr   Lys Glu Gly 
    18860                 18865                 18870             


Lys Val   Leu Val Arg Glu Lys   Arg Val Asp Leu Ile   Gln Asp Leu 
    18875                 18880                 18885             


Pro Arg   Val Glu Leu Gln Ile   Lys Glu Ala Val Arg   Ala Asp His 
    18890                 18895                 18900             


Gly Lys   Tyr Ile Ile Ser Ala   Lys Asn Ser Ser Gly   His Ala Gln 
    18905                 18910                 18915             


Gly Ser   Ala Ile Val Asn Val   Leu Asp Arg Pro Gly   Pro Cys Gln 
    18920                 18925                 18930             


Asn Leu   Lys Val Thr Asn Val   Thr Lys Glu Asn Cys   Thr Ile Ser 
    18935                 18940                 18945             


Trp Glu   Asn Pro Leu Asp Asn   Gly Gly Ser Glu Ile   Thr Asn Phe 
    18950                 18955                 18960             


Ile Val   Glu Tyr Arg Lys Pro   Asn Gln Lys Gly Trp   Ser Ile Val 
    18965                 18970                 18975             


Ala Ser   Asp Val Thr Lys Arg   Leu Ile Lys Ala Asn   Leu Leu Ala 
    18980                 18985                 18990             


Asn Asn   Glu Tyr Tyr Phe Arg   Val Cys Ala Glu Asn   Lys Val Gly 
    18995                 19000                 19005             


Val Gly   Pro Thr Ile Glu Thr   Lys Thr Pro Ile Leu   Ala Ile Asn 
    19010                 19015                 19020             


Pro Ile   Asp Arg Pro Gly Glu   Pro Glu Asn Leu His   Ile Ala Asp 
    19025                 19030                 19035             


Lys Gly   Lys Thr Phe Val Tyr   Leu Lys Trp Arg Arg   Pro Asp Tyr 
    19040                 19045                 19050             


Asp Gly   Gly Ser Pro Asn Leu   Ser Tyr His Val Glu   Arg Arg Leu 
    19055                 19060                 19065             


Lys Gly   Ser Asp Asp Trp Glu   Arg Val His Lys Gly   Ser Ile Lys 
    19070                 19075                 19080             


Glu Thr   His Tyr Met Val Asp   Arg Cys Val Glu Asn   Gln Ile Tyr 
    19085                 19090                 19095             


Glu Phe   Arg Val Gln Thr Lys   Asn Glu Gly Gly Glu   Ser Asp Trp 
    19100                 19105                 19110             


Val Lys   Thr Glu Glu Val Val   Val Lys Glu Asp Leu   Gln Lys Pro 
    19115                 19120                 19125             


Val Leu   Asp Leu Lys Leu Ser   Gly Val Leu Thr Val   Lys Ala Gly 
    19130                 19135                 19140             


Asp Thr   Ile Arg Leu Glu Ala   Gly Val Arg Gly Lys   Pro Phe Pro 
    19145                 19150                 19155             


Glu Val   Ala Trp Thr Lys Asp   Lys Asp Ala Thr Asp   Leu Thr Arg 
    19160                 19165                 19170             


Ser Pro   Arg Val Lys Ile Asp   Thr Arg Ala Asp Ser   Ser Lys Phe 
    19175                 19180                 19185             


Ser Leu   Thr Lys Ala Lys Arg   Ser Asp Gly Gly Lys   Tyr Val Val 
    19190                 19195                 19200             


Thr Ala   Thr Asn Thr Ala Gly   Ser Phe Val Ala Tyr   Ala Thr Val 
    19205                 19210                 19215             


Asn Val   Leu Asp Lys Pro Gly   Pro Val Arg Asn Leu   Lys Ile Val 
    19220                 19225                 19230             


Asp Val   Ser Ser Asp Arg Cys   Thr Val Cys Trp Asp   Pro Pro Glu 
    19235                 19240                 19245             


Asp Asp   Gly Gly Cys Glu Ile   Gln Asn Tyr Ile Leu   Glu Lys Cys 
    19250                 19255                 19260             


Glu Thr   Lys Arg Met Val Trp   Ser Thr Tyr Ser Ala   Thr Val Leu 
    19265                 19270                 19275             


Thr Pro   Gly Thr Thr Val Thr   Arg Leu Ile Glu Gly   Asn Glu Tyr 
    19280                 19285                 19290             


Ile Phe   Arg Val Arg Ala Glu   Asn Lys Ile Gly Thr   Gly Pro Pro 
    19295                 19300                 19305             


Thr Glu   Ser Lys Pro Val Ile   Ala Lys Thr Lys Tyr   Asp Lys Pro 
    19310                 19315                 19320             


Gly Arg   Pro Asp Pro Pro Glu   Val Thr Lys Val Ser   Lys Glu Glu 
    19325                 19330                 19335             


Met Thr   Val Val Trp Asn Pro   Pro Glu Tyr Asp Gly   Gly Lys Ser 
    19340                 19345                 19350             


Ile Thr   Gly Tyr Phe Leu Glu   Lys Lys Glu Lys His   Ser Thr Arg 
    19355                 19360                 19365             


Trp Val   Pro Val Asn Lys Ser   Ala Ile Pro Glu Arg   Arg Met Lys 
    19370                 19375                 19380             


Val Gln   Asn Leu Leu Pro Asp   His Glu Tyr Gln Phe   Arg Val Lys 
    19385                 19390                 19395             


Ala Glu   Asn Glu Ile Gly Ile   Gly Glu Pro Ser Leu   Pro Ser Arg 
    19400                 19405                 19410             


Pro Val   Val Ala Lys Asp Pro   Ile Glu Pro Pro Gly   Pro Pro Thr 
    19415                 19420                 19425             


Asn Phe   Arg Val Val Asp Thr   Thr Lys His Ser Ile   Thr Leu Gly 
    19430                 19435                 19440             


Trp Gly   Lys Pro Val Tyr Asp   Gly Gly Ala Pro Ile   Ile Gly Tyr 
    19445                 19450                 19455             


Val Val   Glu Met Arg Pro Lys   Ile Ala Asp Ala Ser   Pro Asp Glu 
    19460                 19465                 19470             


Gly Trp   Lys Arg Cys Asn Ala   Ala Ala Gln Leu Val   Arg Lys Glu 
    19475                 19480                 19485             


Phe Thr   Val Thr Ser Leu Asp   Glu Asn Gln Glu Tyr   Glu Phe Arg 
    19490                 19495                 19500             


Val Cys   Ala Gln Asn Gln Val   Gly Ile Gly Arg Pro   Ala Glu Leu 
    19505                 19510                 19515             


Lys Glu   Ala Ile Lys Pro Lys   Glu Ile Leu Glu Pro   Pro Glu Ile 
    19520                 19525                 19530             


Asp Leu   Asp Ala Ser Met Arg   Lys Leu Val Ile Val   Arg Ala Gly 
    19535                 19540                 19545             


Cys Pro   Ile Arg Leu Phe Ala   Ile Val Arg Gly Arg   Pro Ala Pro 
    19550                 19555                 19560             


Lys Val   Thr Trp Arg Lys Val   Gly Ile Asp Asn Val   Val Arg Lys 
    19565                 19570                 19575             


Gly Gln   Val Asp Leu Val Asp   Thr Met Ala Phe Leu   Val Ile Pro 
    19580                 19585                 19590             


Asn Ser   Thr Arg Asp Asp Ser   Gly Lys Tyr Ser Leu   Thr Leu Val 
    19595                 19600                 19605             


Asn Pro   Ala Gly Glu Lys Ala   Val Phe Val Asn Val   Arg Val Leu 
    19610                 19615                 19620             


Asp Thr   Pro Gly Pro Val Ser   Asp Leu Lys Val Ser   Asp Val Thr 
    19625                 19630                 19635             


Lys Thr   Ser Cys His Val Ser   Trp Ala Pro Pro Glu   Asn Asp Gly 
    19640                 19645                 19650             


Gly Ser   Gln Val Thr His Tyr   Ile Val Glu Lys Arg   Glu Ala Asp 
    19655                 19660                 19665             


Arg Lys   Thr Trp Ser Thr Val   Thr Pro Glu Val Lys   Lys Thr Ser 
    19670                 19675                 19680             


Phe His   Val Thr Asn Leu Val   Pro Gly Asn Glu Tyr   Tyr Phe Arg 
    19685                 19690                 19695             


Val Thr   Ala Val Asn Glu Tyr   Gly Pro Gly Val Pro   Thr Asp Val 
    19700                 19705                 19710             


Pro Lys   Pro Val Leu Ala Ser   Asp Pro Leu Ser Glu   Pro Asp Pro 
    19715                 19720                 19725             


Pro Arg   Lys Leu Glu Val Thr   Glu Met Thr Lys Asn   Ser Ala Thr 
    19730                 19735                 19740             


Leu Ala   Trp Leu Pro Pro Leu   Arg Asp Gly Gly Ala   Lys Ile Asp 
    19745                 19750                 19755             


Gly Tyr   Ile Thr Ser Tyr Arg   Glu Glu Glu Gln Pro   Ala Asp Arg 
    19760                 19765                 19770             


Trp Thr   Glu Tyr Ser Val Val   Lys Asp Leu Ser Leu   Val Val Thr 
    19775                 19780                 19785             


Gly Leu   Lys Glu Gly Lys Lys   Tyr Lys Phe Arg Val   Ala Ala Arg 
    19790                 19795                 19800             


Asn Ala   Val Gly Val Ser Leu   Pro Arg Glu Ala Glu   Gly Val Tyr 
    19805                 19810                 19815             


Glu Ala   Lys Glu Gln Leu Leu   Pro Pro Lys Ile Leu   Met Pro Glu 
    19820                 19825                 19830             


Gln Ile   Thr Ile Lys Ala Gly   Lys Lys Leu Arg Ile   Glu Ala His 
    19835                 19840                 19845             


Val Tyr   Gly Lys Pro His Pro   Thr Cys Lys Trp Lys   Lys Gly Glu 
    19850                 19855                 19860             


Asp Glu   Val Val Thr Ser Ser   His Leu Ala Val His   Lys Ala Asp 
    19865                 19870                 19875             


Ser Ser   Ser Ile Leu Ile Ile   Lys Asp Val Thr Arg   Lys Asp Ser 
    19880                 19885                 19890             


Gly Tyr   Tyr Ser Leu Thr Ala   Glu Asn Ser Ser Gly   Thr Asp Thr 
    19895                 19900                 19905             


Gln Lys   Ile Lys Val Val Val   Met Asp Ala Pro Gly   Pro Pro Gln 
    19910                 19915                 19920             


Pro Pro   Phe Asp Ile Ser Asp   Ile Asp Ala Asp Ala   Cys Ser Leu 
    19925                 19930                 19935             


Ser Trp   His Ile Pro Leu Glu   Asp Gly Gly Ser Asn   Ile Thr Asn 
    19940                 19945                 19950             


Tyr Ile   Val Glu Lys Cys Asp   Val Ser Arg Gly Asp   Trp Val Thr 
    19955                 19960                 19965             


Ala Leu   Ala Ser Val Thr Lys   Thr Ser Cys Arg Val   Gly Lys Leu 
    19970                 19975                 19980             


Ile Pro   Gly Gln Glu Tyr Ile   Phe Arg Val Arg Ala   Glu Asn Arg 
    19985                 19990                 19995             


Phe Gly   Ile Ser Glu Pro Leu   Thr Ser Pro Lys Met   Val Ala Gln 
    20000                 20005                 20010             


Phe Pro   Phe Gly Val Pro Ser   Glu Pro Lys Asn Ala   Arg Val Thr 
    20015                 20020                 20025             


Lys Val   Asn Lys Asp Cys Ile   Phe Val Ala Trp Asp   Arg Pro Asp 
    20030                 20035                 20040             


Ser Asp   Gly Gly Ser Pro Ile   Ile Gly Tyr Leu Ile   Glu Arg Lys 
    20045                 20050                 20055             


Glu Arg   Asn Ser Leu Leu Trp   Val Lys Ala Asn Asp   Thr Leu Val 
    20060                 20065                 20070             


Arg Ser   Thr Glu Tyr Pro Cys   Ala Gly Leu Val Glu   Gly Leu Glu 
    20075                 20080                 20085             


Tyr Ser   Phe Arg Ile Tyr Ala   Leu Asn Lys Ala Gly   Ser Ser Pro 
    20090                 20095                 20100             


Pro Ser   Lys Pro Thr Glu Tyr   Val Thr Ala Arg Met   Pro Val Asp 
    20105                 20110                 20115             


Pro Pro   Gly Lys Pro Glu Val   Ile Asp Val Thr Lys   Ser Thr Val 
    20120                 20125                 20130             


Ser Leu   Ile Trp Ala Arg Pro   Lys His Asp Gly Gly   Ser Lys Ile 
    20135                 20140                 20145             


Ile Gly   Tyr Phe Val Glu Ala   Cys Lys Leu Pro Gly   Asp Lys Trp 
    20150                 20155                 20160             


Val Arg   Cys Asn Thr Ala Pro   His Gln Ile Pro Gln   Glu Glu Tyr 
    20165                 20170                 20175             


Thr Ala   Thr Gly Leu Glu Glu   Lys Ala Gln Tyr Gln   Phe Arg Ala 
    20180                 20185                 20190             


Ile Ala   Arg Thr Ala Val Asn   Ile Ser Pro Pro Ser   Glu Pro Ser 
    20195                 20200                 20205             


Asp Pro   Val Thr Ile Leu Ala   Glu Asn Val Pro Pro   Arg Ile Asp 
    20210                 20215                 20220             


Leu Ser   Val Ala Met Lys Ser   Leu Leu Thr Val Lys   Ala Gly Thr 
    20225                 20230                 20235             


Asn Val   Cys Leu Asp Ala Thr   Val Phe Gly Lys Pro   Met Pro Thr 
    20240                 20245                 20250             


Val Ser   Trp Lys Lys Asp Gly   Thr Leu Leu Lys Pro   Ala Glu Gly 
    20255                 20260                 20265             


Ile Lys   Met Ala Met Gln Arg   Asn Leu Cys Thr Leu   Glu Leu Phe 
    20270                 20275                 20280             


Ser Val   Asn Arg Lys Asp Ser   Gly Asp Tyr Thr Ile   Thr Ala Glu 
    20285                 20290                 20295             


Asn Ser   Ser Gly Ser Lys Ser   Ala Thr Ile Lys Leu   Lys Val Leu 
    20300                 20305                 20310             


Asp Lys   Pro Gly Pro Pro Ala   Ser Val Lys Ile Asn   Lys Met Tyr 
    20315                 20320                 20325             


Ser Asp   Arg Ala Met Leu Ser   Trp Glu Pro Pro Leu   Glu Asp Gly 
    20330                 20335                 20340             


Gly Ser   Glu Ile Thr Asn Tyr   Ile Val Asp Lys Arg   Glu Thr Ser 
    20345                 20350                 20355             


Arg Pro   Asn Trp Ala Gln Val   Ser Ala Thr Val Pro   Ile Thr Ser 
    20360                 20365                 20370             


Cys Ser   Val Glu Lys Leu Ile   Glu Gly His Glu Tyr   Gln Phe Arg 
    20375                 20380                 20385             


Ile Cys   Ala Glu Asn Lys Tyr   Gly Val Gly Asp Pro   Val Phe Thr 
    20390                 20395                 20400             


Glu Pro   Ala Ile Ala Lys Asn   Pro Tyr Asp Pro Pro   Gly Arg Cys 
    20405                 20410                 20415             


Asp Pro   Pro Val Ile Ser Asn   Ile Thr Lys Asp His   Met Thr Val 
    20420                 20425                 20430             


Ser Trp   Lys Pro Pro Ala Asp   Asp Gly Gly Ser Pro   Ile Thr Gly 
    20435                 20440                 20445             


Tyr Leu   Leu Glu Lys Arg Glu   Thr Gln Ala Val Asn   Trp Thr Lys 
    20450                 20455                 20460             


Val Asn   Arg Lys Pro Ile Ile   Glu Arg Thr Leu Lys   Ala Thr Gly 
    20465                 20470                 20475             


Leu Gln   Glu Gly Thr Glu Tyr   Glu Phe Arg Val Thr   Ala Ile Asn 
    20480                 20485                 20490             


Lys Ala   Gly Pro Gly Lys Pro   Ser Asp Ala Ser Lys   Ala Ala Tyr 
    20495                 20500                 20505             


Ala Arg   Asp Pro Gln Tyr Pro   Pro Ala Pro Pro Ala   Phe Pro Lys 
    20510                 20515                 20520             


Val Tyr   Asp Thr Thr Arg Ser   Ser Val Ser Leu Ser   Trp Gly Lys 
    20525                 20530                 20535             


Pro Ala   Tyr Asp Gly Gly Ser   Pro Ile Ile Gly Tyr   Leu Val Glu 
    20540                 20545                 20550             


Val Lys   Arg Ala Asp Ser Asp   Asn Trp Val Arg Cys   Asn Leu Pro 
    20555                 20560                 20565             


Gln Asn   Leu Gln Lys Thr Arg   Phe Glu Val Thr Gly   Leu Met Glu 
    20570                 20575                 20580             


Asp Thr   Gln Tyr Gln Phe Arg   Val Tyr Ala Val Asn   Lys Ile Gly 
    20585                 20590                 20595             


Tyr Ser   Asp Pro Ser Asp Val   Pro Asp Lys His Tyr   Pro Lys Asp 
    20600                 20605                 20610             


Ile Leu   Ile Pro Pro Glu Gly   Glu Leu Asp Ala Asp   Leu Arg Lys 
    20615                 20620                 20625             


Thr Leu   Ile Leu Arg Ala Gly   Val Thr Met Arg Leu   Tyr Val Pro 
    20630                 20635                 20640             


Val Lys   Gly Arg Pro Pro Pro   Lys Ile Thr Trp Ser   Lys Pro Asn 
    20645                 20650                 20655             


Val Asn   Leu Arg Asp Arg Ile   Gly Leu Asp Ile Lys   Ser Thr Asp 
    20660                 20665                 20670             


Phe Asp   Thr Phe Leu Arg Cys   Glu Asn Val Asn Lys   Tyr Asp Ala 
    20675                 20680                 20685             


Gly Lys   Tyr Ile Leu Thr Leu   Glu Asn Ser Cys Gly   Lys Lys Glu 
    20690                 20695                 20700             


Tyr Thr   Ile Val Val Lys Val   Leu Asp Thr Pro Gly   Pro Pro Val 
    20705                 20710                 20715             


Asn Val   Thr Val Lys Glu Ile   Ser Lys Asp Ser Ala   Tyr Val Thr 
    20720                 20725                 20730             


Trp Glu   Pro Pro Ile Ile Asp   Gly Gly Ser Pro Ile   Ile Asn Tyr 
    20735                 20740                 20745             


Val Val   Gln Lys Arg Asp Ala   Glu Arg Lys Ser Trp   Ser Thr Val 
    20750                 20755                 20760             


Thr Thr   Glu Cys Ser Lys Thr   Ser Phe Arg Val Ala   Asn Leu Glu 
    20765                 20770                 20775             


Glu Gly   Lys Ser Tyr Phe Phe   Arg Val Phe Ala Glu   Asn Glu Tyr 
    20780                 20785                 20790             


Gly Ile   Gly Asp Pro Gly Glu   Thr Arg Asp Ala Val   Lys Ala Ser 
    20795                 20800                 20805             


Gln Thr   Pro Gly Pro Val Val   Asp Leu Lys Val Arg   Ser Val Ser 
    20810                 20815                 20820             


Lys Ser   Ser Cys Ser Ile Gly   Trp Lys Lys Pro His   Ser Asp Gly 
    20825                 20830                 20835             


Gly Ser   Arg Ile Ile Gly Tyr   Val Val Asp Phe Leu   Thr Glu Glu 
    20840                 20845                 20850             


Asn Lys   Trp Gln Arg Val Met   Lys Ser Leu Ser Leu   Gln Tyr Ser 
    20855                 20860                 20865             


Ala Lys   Asp Leu Thr Glu Gly   Lys Glu Tyr Thr Phe   Arg Val Ser 
    20870                 20875                 20880             


Ala Glu   Asn Glu Asn Gly Glu   Gly Thr Pro Ser Glu   Ile Thr Val 
    20885                 20890                 20895             


Val Ala   Arg Asp Asp Val Val   Ala Pro Asp Leu Asp   Leu Lys Gly 
    20900                 20905                 20910             


Leu Pro   Asp Leu Cys Tyr Leu   Ala Lys Glu Asn Ser   Asn Phe Arg 
    20915                 20920                 20925             


Leu Lys   Ile Pro Ile Lys Gly   Lys Pro Ala Pro Ser   Val Ser Trp 
    20930                 20935                 20940             


Lys Lys   Gly Glu Asp Pro Leu   Ala Thr Asp Thr Arg   Val Ser Val 
    20945                 20950                 20955             


Glu Ser   Ser Ala Val Asn Thr   Thr Leu Ile Val Tyr   Asp Cys Gln 
    20960                 20965                 20970             


Lys Ser   Asp Ala Gly Lys Tyr   Thr Ile Thr Leu Lys   Asn Val Ala 
    20975                 20980                 20985             


Gly Thr   Lys Glu Gly Thr Ile   Ser Ile Lys Val Val   Gly Lys Pro 
    20990                 20995                 21000             


Gly Ile   Pro Thr Gly Pro Ile   Lys Phe Asp Glu Val   Thr Ala Glu 
    21005                 21010                 21015             


Ala Met   Thr Leu Lys Trp Ala   Pro Pro Lys Asp Asp   Gly Gly Ser 
    21020                 21025                 21030             


Glu Ile   Thr Asn Tyr Ile Leu   Glu Lys Arg Asp Ser   Val Asn Asn 
    21035                 21040                 21045             


Lys Trp   Val Thr Cys Ala Ser   Ala Val Gln Lys Thr   Thr Phe Arg 
    21050                 21055                 21060             


Val Thr   Arg Leu His Glu Gly   Met Glu Tyr Thr Phe   Arg Val Ser 
    21065                 21070                 21075             


Ala Glu   Asn Lys Tyr Gly Val   Gly Glu Gly Leu Lys   Ser Glu Pro 
    21080                 21085                 21090             


Ile Val   Ala Arg His Pro Phe   Asp Val Pro Asp Ala   Pro Pro Pro 
    21095                 21100                 21105             


Pro Asn   Ile Val Asp Val Arg   His Asp Ser Val Ser   Leu Thr Trp 
    21110                 21115                 21120             


Thr Asp   Pro Lys Lys Thr Gly   Gly Ser Pro Ile Thr   Gly Tyr His 
    21125                 21130                 21135             


Leu Glu   Phe Lys Glu Arg Asn   Ser Leu Leu Trp Lys   Arg Ala Asn 
    21140                 21145                 21150             


Lys Thr   Pro Ile Arg Met Arg   Asp Phe Lys Val Thr   Gly Leu Thr 
    21155                 21160                 21165             


Glu Gly   Leu Glu Tyr Glu Phe   Arg Val Met Ala Ile   Asn Leu Ala 
    21170                 21175                 21180             


Gly Val   Gly Lys Pro Ser Leu   Pro Ser Glu Pro Val   Val Ala Leu 
    21185                 21190                 21195             


Asp Pro   Ile Asp Pro Pro Gly   Lys Pro Glu Val Ile   Asn Ile Thr 
    21200                 21205                 21210             


Arg Asn   Ser Val Thr Leu Ile   Trp Thr Glu Pro Lys   Tyr Asp Gly 
    21215                 21220                 21225             


Gly His   Lys Leu Thr Gly Tyr   Ile Val Glu Lys Arg   Asp Leu Pro 
    21230                 21235                 21240             


Ser Lys   Ser Trp Met Lys Ala   Asn His Val Asn Val   Pro Glu Cys 
    21245                 21250                 21255             


Ala Phe   Thr Val Thr Asp Leu   Val Glu Gly Gly Lys   Tyr Glu Phe 
    21260                 21265                 21270             


Arg Ile   Arg Ala Lys Asn Thr   Ala Gly Ala Ile Ser   Ala Pro Ser 
    21275                 21280                 21285             


Glu Ser   Thr Glu Thr Ile Ile   Cys Lys Asp Glu Tyr   Glu Ala Pro 
    21290                 21295                 21300             


Thr Ile   Val Leu Asp Pro Thr   Ile Lys Asp Gly Leu   Thr Ile Lys 
    21305                 21310                 21315             


Ala Gly   Asp Thr Ile Val Leu   Asn Ala Ile Ser Ile   Leu Gly Lys 
    21320                 21325                 21330             


Pro Leu   Pro Lys Ser Ser Trp   Ser Lys Ala Gly Lys   Asp Ile Arg 
    21335                 21340                 21345             


Pro Ser   Asp Ile Thr Gln Ile   Thr Ser Thr Pro Thr   Ser Ser Met 
    21350                 21355                 21360             


Leu Thr   Ile Lys Tyr Ala Thr   Arg Lys Asp Ala Gly   Glu Tyr Thr 
    21365                 21370                 21375             


Ile Thr   Ala Thr Asn Pro Phe   Gly Thr Lys Val Glu   His Val Lys 
    21380                 21385                 21390             


Val Thr   Val Leu Asp Val Pro   Gly Pro Pro Gly Pro   Val Glu Ile 
    21395                 21400                 21405             


Ser Asn   Val Ser Ala Glu Lys   Ala Thr Leu Thr Trp   Thr Pro Pro 
    21410                 21415                 21420             


Leu Glu   Asp Gly Gly Ser Pro   Ile Lys Ser Tyr Ile   Leu Glu Lys 
    21425                 21430                 21435             


Arg Glu   Thr Ser Arg Leu Leu   Trp Thr Val Val Ser   Glu Asp Ile 
    21440                 21445                 21450             


Gln Ser   Cys Arg His Val Ala   Thr Lys Leu Ile Gln   Gly Asn Glu 
    21455                 21460                 21465             


Tyr Ile   Phe Arg Val Ser Ala   Val Asn His Tyr Gly   Lys Gly Glu 
    21470                 21475                 21480             


Pro Val   Gln Ser Glu Pro Val   Lys Met Val Asp Arg   Phe Gly Pro 
    21485                 21490                 21495             


Pro Gly   Pro Pro Glu Lys Pro   Glu Val Ser Asn Val   Thr Lys Asn 
    21500                 21505                 21510             


Thr Ala   Thr Val Ser Trp Lys   Arg Pro Val Asp Asp   Gly Gly Ser 
    21515                 21520                 21525             


Glu Ile   Thr Gly Tyr His Val   Glu Arg Arg Glu Lys   Lys Ser Leu 
    21530                 21535                 21540             


Arg Trp   Val Arg Ala Ile Lys   Thr Pro Val Ser Asp   Leu Arg Cys 
    21545                 21550                 21555             


Lys Val   Thr Gly Leu Gln Glu   Gly Ser Thr Tyr Glu   Phe Arg Val 
    21560                 21565                 21570             


Ser Ala   Glu Asn Arg Ala Gly   Ile Gly Pro Pro Ser   Glu Ala Ser 
    21575                 21580                 21585             


Asp Ser   Val Leu Met Lys Asp   Ala Ala Tyr Pro Pro   Gly Pro Pro 
    21590                 21595                 21600             


Ser Asn   Pro His Val Thr Asp   Thr Thr Lys Lys Ser   Ala Ser Leu 
    21605                 21610                 21615             


Ala Trp   Gly Lys Pro His Tyr   Asp Gly Gly Leu Glu   Ile Thr Gly 
    21620                 21625                 21630             


Tyr Val   Val Glu His Gln Lys   Val Gly Asp Glu Ala   Trp Ile Lys 
    21635                 21640                 21645             


Asp Thr   Thr Gly Thr Ala Leu   Arg Ile Thr Gln Phe   Val Val Pro 
    21650                 21655                 21660             


Asp Leu   Gln Thr Lys Glu Lys   Tyr Asn Phe Arg Ile   Ser Ala Ile 
    21665                 21670                 21675             


Asn Asp   Ala Gly Val Gly Glu   Pro Ala Val Ile Pro   Asp Val Glu 
    21680                 21685                 21690             


Ile Val   Glu Arg Glu Met Ala   Pro Asp Phe Glu Leu   Asp Ala Glu 
    21695                 21700                 21705             


Leu Arg   Arg Thr Leu Val Val   Arg Ala Gly Leu Ser   Ile Arg Ile 
    21710                 21715                 21720             


Phe Val   Pro Ile Lys Gly Arg   Pro Ala Pro Glu Val   Thr Trp Thr 
    21725                 21730                 21735             


Lys Asp   Asn Ile Asn Leu Lys   Asn Arg Ala Asn Ile   Glu Asn Thr 
    21740                 21745                 21750             


Glu Ser   Phe Thr Leu Leu Ile   Ile Pro Glu Cys Asn   Arg Tyr Asp 
    21755                 21760                 21765             


Thr Gly   Lys Phe Val Met Thr   Ile Glu Asn Pro Ala   Gly Lys Lys 
    21770                 21775                 21780             


Ser Gly   Phe Val Asn Val Arg   Val Leu Asp Thr Pro   Gly Pro Val 
    21785                 21790                 21795             


Leu Asn   Leu Arg Pro Thr Asp   Ile Thr Lys Asp Ser   Val Thr Leu 
    21800                 21805                 21810             


His Trp   Asp Leu Pro Leu Ile   Asp Gly Gly Ser Arg   Ile Thr Asn 
    21815                 21820                 21825             


Tyr Ile   Val Glu Lys Arg Glu   Ala Thr Arg Lys Ser   Tyr Ser Thr 
    21830                 21835                 21840             


Ala Thr   Thr Lys Cys His Lys   Cys Thr Tyr Lys Val   Thr Gly Leu 
    21845                 21850                 21855             


Ser Glu   Gly Cys Glu Tyr Phe   Phe Arg Val Met Ala   Glu Asn Glu 
    21860                 21865                 21870             


Tyr Gly   Ile Gly Glu Pro Thr   Glu Thr Thr Glu Pro   Val Lys Ala 
    21875                 21880                 21885             


Ser Glu   Ala Pro Ser Pro Pro   Asp Ser Leu Asn Ile   Met Asp Ile 
    21890                 21895                 21900             


Thr Lys   Ser Thr Val Ser Leu   Ala Trp Pro Lys Pro   Lys His Asp 
    21905                 21910                 21915             


Gly Gly   Ser Lys Ile Thr Gly   Tyr Val Ile Glu Ala   Gln Arg Lys 
    21920                 21925                 21930             


Gly Ser   Asp Gln Trp Thr His   Ile Thr Thr Val Lys   Gly Leu Glu 
    21935                 21940                 21945             


Cys Val   Val Arg Asn Leu Thr   Glu Gly Glu Glu Tyr   Thr Phe Gln 
    21950                 21955                 21960             


Val Met   Ala Val Asn Ser Ala   Gly Arg Ser Ala Pro   Arg Glu Ser 
    21965                 21970                 21975             


Arg Pro   Val Ile Val Lys Glu   Gln Thr Met Leu Pro   Glu Leu Asp 
    21980                 21985                 21990             


Leu Arg   Gly Ile Tyr Gln Lys   Leu Val Ile Ala Lys   Ala Gly Asp 
    21995                 22000                 22005             


Asn Ile   Lys Val Glu Ile Pro   Val Leu Gly Arg Pro   Lys Pro Thr 
    22010                 22015                 22020             


Val Thr   Trp Lys Lys Gly Asp   Gln Ile Leu Lys Gln   Thr Gln Arg 
    22025                 22030                 22035             


Val Asn   Phe Glu Thr Thr Ala   Thr Ser Thr Ile Leu   Asn Ile Asn 
    22040                 22045                 22050             


Glu Cys   Val Arg Ser Asp Ser   Gly Pro Tyr Pro Leu   Thr Ala Arg 
    22055                 22060                 22065             


Asn Ile   Val Gly Glu Val Gly   Asp Val Ile Thr Ile   Gln Val His 
    22070                 22075                 22080             


Asp Ile   Pro Gly Pro Pro Thr   Gly Pro Ile Lys Phe   Asp Glu Val 
    22085                 22090                 22095             


Ser Ser   Asp Phe Val Thr Phe   Ser Trp Asp Pro Pro   Glu Asn Asp 
    22100                 22105                 22110             


Gly Gly   Val Pro Ile Ser Asn   Tyr Val Val Glu Met   Arg Gln Thr 
    22115                 22120                 22125             


Asp Ser   Thr Thr Trp Val Glu   Leu Ala Thr Thr Val   Ile Arg Thr 
    22130                 22135                 22140             


Thr Tyr   Lys Ala Thr Arg Leu   Thr Thr Gly Leu Glu   Tyr Gln Phe 
    22145                 22150                 22155             


Arg Val   Lys Ala Gln Asn Arg   Tyr Gly Val Gly Pro   Gly Ile Thr 
    22160                 22165                 22170             


Ser Ala   Cys Ile Val Ala Asn   Tyr Pro Phe Lys Val   Pro Gly Pro 
    22175                 22180                 22185             


Pro Gly   Thr Pro Gln Val Thr   Ala Val Thr Lys Asp   Ser Met Thr 
    22190                 22195                 22200             


Ile Ser   Trp His Glu Pro Leu   Ser Asp Gly Gly Ser   Pro Ile Leu 
    22205                 22210                 22215             


Gly Tyr   His Val Glu Arg Lys   Glu Arg Asn Gly Ile   Leu Trp Gln 
    22220                 22225                 22230             


Thr Val   Ser Lys Ala Leu Val   Pro Gly Asn Ile Phe   Lys Ser Ser 
    22235                 22240                 22245             


Gly Leu   Thr Asp Gly Ile Ala   Tyr Glu Phe Arg Val   Ile Ala Glu 
    22250                 22255                 22260             


Asn Met   Ala Gly Lys Ser Lys   Pro Ser Lys Pro Ser   Glu Pro Met 
    22265                 22270                 22275             


Leu Ala   Leu Asp Pro Ile Asp   Pro Pro Gly Lys Pro   Val Pro Leu 
    22280                 22285                 22290             


Asn Ile   Thr Arg His Thr Val   Thr Leu Lys Trp Ala   Lys Pro Glu 
    22295                 22300                 22305             


Tyr Thr   Gly Gly Phe Lys Ile   Thr Ser Tyr Ile Val   Glu Lys Arg 
    22310                 22315                 22320             


Asp Leu   Pro Asn Gly Arg Trp   Leu Lys Ala Asn Phe   Ser Asn Ile 
    22325                 22330                 22335             


Leu Glu   Asn Glu Phe Thr Val   Ser Gly Leu Thr Glu   Asp Ala Ala 
    22340                 22345                 22350             


Tyr Glu   Phe Arg Val Ile Ala   Lys Asn Ala Ala Gly   Ala Ile Ser 
    22355                 22360                 22365             


Pro Pro   Ser Glu Pro Ser Asp   Ala Ile Thr Cys Arg   Asp Asp Val 
    22370                 22375                 22380             


Glu Ala   Pro Lys Ile Lys Val   Asp Val Lys Phe Lys   Asp Thr Val 
    22385                 22390                 22395             


Ile Leu   Lys Ala Gly Glu Ala   Phe Arg Leu Glu Ala   Asp Val Ser 
    22400                 22405                 22410             


Gly Arg   Pro Pro Pro Thr Met   Glu Trp Ser Lys Asp   Gly Lys Glu 
    22415                 22420                 22425             


Leu Glu   Gly Thr Ala Lys Leu   Glu Ile Lys Ile Ala   Asp Phe Ser 
    22430                 22435                 22440             


Thr Asn   Leu Val Asn Lys Asp   Ser Thr Arg Arg Asp   Ser Gly Ala 
    22445                 22450                 22455             


Tyr Thr   Leu Thr Ala Thr Asn   Pro Gly Gly Phe Ala   Lys His Ile 
    22460                 22465                 22470             


Phe Asn   Val Lys Val Leu Asp   Arg Pro Gly Pro Pro   Glu Gly Pro 
    22475                 22480                 22485             


Leu Ala   Val Thr Glu Val Thr   Ser Glu Lys Cys Val   Leu Ser Trp 
    22490                 22495                 22500             


Phe Pro   Pro Leu Asp Asp Gly   Gly Ala Lys Ile Asp   His Tyr Ile 
    22505                 22510                 22515             


Val Gln   Lys Arg Glu Thr Ser   Arg Leu Ala Trp Thr   Asn Val Ala 
    22520                 22525                 22530             


Ser Glu   Val Gln Val Thr Lys   Leu Lys Val Thr Lys   Leu Leu Lys 
    22535                 22540                 22545             


Gly Asn   Glu Tyr Ile Phe Arg   Val Met Ala Val Asn   Lys Tyr Gly 
    22550                 22555                 22560             


Val Gly   Glu Pro Leu Glu Ser   Glu Pro Val Leu Ala   Val Asn Pro 
    22565                 22570                 22575             


Tyr Gly   Pro Pro Asp Pro Pro   Lys Asn Pro Glu Val   Thr Thr Ile 
    22580                 22585                 22590             


Thr Lys   Asp Ser Met Val Val   Cys Trp Gly His Pro   Asp Ser Asp 
    22595                 22600                 22605             


Gly Gly   Ser Glu Ile Ile Asn   Tyr Ile Val Glu Arg   Arg Asp Lys 
    22610                 22615                 22620             


Ala Gly   Gln Arg Trp Ile Lys   Cys Asn Lys Lys Thr   Leu Thr Asp 
    22625                 22630                 22635             


Leu Arg   Tyr Lys Val Ser Gly   Leu Thr Glu Gly His   Glu Tyr Glu 
    22640                 22645                 22650             


Phe Arg   Ile Met Ala Glu Asn   Ala Ala Gly Ile Ser   Ala Pro Ser 
    22655                 22660                 22665             


Pro Thr   Ser Pro Phe Tyr Lys   Ala Cys Asp Thr Val   Phe Lys Pro 
    22670                 22675                 22680             


Gly Pro   Pro Gly Asn Pro Arg   Val Leu Asp Thr Ser   Arg Ser Ser 
    22685                 22690                 22695             


Ile Ser   Ile Ala Trp Asn Lys   Pro Ile Tyr Asp Gly   Gly Ser Glu 
    22700                 22705                 22710             


Ile Thr   Gly Tyr Met Val Glu   Ile Ala Leu Pro Glu   Glu Asp Glu 
    22715                 22720                 22725             


Trp Gln   Ile Val Thr Pro Pro   Ala Gly Leu Lys Ala   Thr Ser Tyr 
    22730                 22735                 22740             


Thr Ile   Thr Gly Leu Thr Glu   Asn Gln Glu Tyr Lys   Ile Arg Ile 
    22745                 22750                 22755             


Tyr Ala   Met Asn Ser Glu Gly   Leu Gly Glu Pro Ala   Leu Val Pro 
    22760                 22765                 22770             


Gly Thr   Pro Lys Ala Glu Asp   Arg Met Leu Pro Pro   Glu Ile Glu 
    22775                 22780                 22785             


Leu Asp   Ala Asp Leu Arg Lys   Val Val Thr Ile Arg   Ala Cys Cys 
    22790                 22795                 22800             


Thr Leu   Arg Leu Phe Val Pro   Ile Lys Gly Arg Pro   Ala Pro Glu 
    22805                 22810                 22815             


Val Lys   Trp Ala Arg Asp His   Gly Glu Ser Leu Asp   Lys Ala Ser 
    22820                 22825                 22830             


Ile Glu   Ser Thr Ser Ser Tyr   Thr Leu Leu Ile Val   Gly Asn Val 
    22835                 22840                 22845             


Asn Arg   Phe Asp Ser Gly Lys   Tyr Ile Leu Thr Val   Glu Asn Ser 
    22850                 22855                 22860             


Ser Gly   Ser Lys Ser Ala Phe   Val Asn Val Arg Val   Leu Asp Thr 
    22865                 22870                 22875             


Pro Gly   Pro Pro Gln Asp Leu   Lys Val Lys Glu Val   Thr Lys Thr 
    22880                 22885                 22890             


Ser Val   Thr Leu Thr Trp Asp   Pro Pro Leu Leu Asp   Gly Gly Ser 
    22895                 22900                 22905             


Lys Ile   Lys Asn Tyr Ile Val   Glu Lys Arg Glu Ser   Thr Arg Lys 
    22910                 22915                 22920             


Ala Tyr   Ser Thr Val Ala Thr   Asn Cys His Lys Thr   Ser Trp Lys 
    22925                 22930                 22935             


Val Asp   Gln Leu Gln Glu Gly   Cys Ser Tyr Tyr Phe   Arg Val Leu 
    22940                 22945                 22950             


Ala Glu   Asn Glu Tyr Gly Ile   Gly Leu Pro Ala Glu   Thr Ala Glu 
    22955                 22960                 22965             


Ser Val   Lys Ala Ser Glu Arg   Pro Leu Pro Pro Gly   Lys Ile Thr 
    22970                 22975                 22980             


Leu Met   Asp Val Thr Arg Asn   Ser Val Ser Leu Ser   Trp Glu Lys 
    22985                 22990                 22995             


Pro Glu   His Asp Gly Gly Ser   Arg Ile Leu Gly Tyr   Ile Val Glu 
    23000                 23005                 23010             


Met Gln   Thr Lys Gly Ser Asp   Lys Trp Ala Thr Cys   Ala Thr Val 
    23015                 23020                 23025             


Lys Val   Thr Glu Ala Thr Ile   Thr Gly Leu Ile Gln   Gly Glu Glu 
    23030                 23035                 23040             


Tyr Ser   Phe Arg Val Ser Ala   Gln Asn Glu Lys Gly   Ile Ser Asp 
    23045                 23050                 23055             


Pro Arg   Gln Leu Ser Val Pro   Val Ile Ala Lys Asp   Leu Val Ile 
    23060                 23065                 23070             


Pro Pro   Ala Phe Lys Leu Leu   Phe Asn Thr Phe Thr   Val Leu Ala 
    23075                 23080                 23085             


Gly Glu   Asp Leu Lys Val Asp   Val Pro Phe Ile Gly   Arg Pro Thr 
    23090                 23095                 23100             


Pro Ala   Val Thr Trp His Lys   Asp Asn Val Pro Leu   Lys Gln Thr 
    23105                 23110                 23115             


Thr Arg   Val Asn Ala Glu Ser   Thr Glu Asn Asn Ser   Leu Leu Thr 
    23120                 23125                 23130             


Ile Lys   Asp Ala Cys Arg Glu   Asp Val Gly His Tyr   Val Val Lys 
    23135                 23140                 23145             


Leu Thr   Asn Ser Ala Gly Glu   Ala Ile Glu Thr Leu   Asn Val Ile 
    23150                 23155                 23160             


Val Leu   Asp Lys Pro Gly Pro   Pro Thr Gly Pro Val   Lys Met Asp 
    23165                 23170                 23175             


Glu Val   Thr Ala Asp Ser Ile   Thr Leu Ser Trp Gly   Pro Pro Lys 
    23180                 23185                 23190             


Tyr Asp   Gly Gly Ser Ser Ile   Asn Asn Tyr Ile Val   Glu Lys Arg 
    23195                 23200                 23205             


Asp Thr   Ser Thr Thr Thr Trp   Gln Ile Val Ser Ala   Thr Val Ala 
    23210                 23215                 23220             


Arg Thr   Thr Ile Lys Ala Cys   Arg Leu Lys Thr Gly   Cys Glu Tyr 
    23225                 23230                 23235             


Gln Phe   Arg Ile Ala Ala Glu   Asn Arg Tyr Gly Lys   Ser Thr Tyr 
    23240                 23245                 23250             


Leu Asn   Ser Glu Pro Thr Val   Ala Gln Tyr Pro Phe   Lys Val Pro 
    23255                 23260                 23265             


Gly Pro   Pro Gly Thr Pro Val   Val Thr Leu Ser Ser   Arg Asp Ser 
    23270                 23275                 23280             


Met Glu   Val Gln Trp Asn Glu   Pro Ile Ser Asp Gly   Gly Ser Arg 
    23285                 23290                 23295             


Val Ile   Gly Tyr His Leu Glu   Arg Lys Glu Arg Asn   Ser Ile Leu 
    23300                 23305                 23310             


Trp Val   Lys Leu Asn Lys Thr   Pro Ile Pro Gln Thr   Lys Phe Lys 
    23315                 23320                 23325             


Thr Thr   Gly Leu Glu Glu Gly   Val Glu Tyr Glu Phe   Arg Val Ser 
    23330                 23335                 23340             


Ala Glu   Asn Ile Val Gly Ile   Gly Lys Pro Ser Lys   Val Ser Glu 
    23345                 23350                 23355             


Cys Tyr   Val Ala Arg Asp Pro   Cys Asp Pro Pro Gly   Arg Pro Glu 
    23360                 23365                 23370             


Ala Ile   Ile Val Thr Arg Asn   Ser Val Thr Leu Gln   Trp Lys Lys 
    23375                 23380                 23385             


Pro Thr   Tyr Asp Gly Gly Ser   Lys Ile Thr Gly Tyr   Ile Val Glu 
    23390                 23395                 23400             


Lys Lys   Glu Leu Pro Glu Gly   Arg Trp Met Lys Ala   Ser Phe Thr 
    23405                 23410                 23415             


Asn Ile   Ile Asp Thr His Phe   Glu Val Thr Gly Leu   Val Glu Asp 
    23420                 23425                 23430             


His Arg   Tyr Glu Phe Arg Val   Ile Ala Arg Asn Ala   Ala Gly Val 
    23435                 23440                 23445             


Phe Ser   Glu Pro Ser Glu Ser   Thr Gly Ala Ile Thr   Ala Arg Asp 
    23450                 23455                 23460             


Glu Val   Asp Pro Pro Arg Ile   Ser Met Asp Pro Lys   Tyr Lys Asp 
    23465                 23470                 23475             


Thr Ile   Val Val His Ala Gly   Glu Ser Phe Lys Val   Asp Ala Asp 
    23480                 23485                 23490             


Ile Tyr   Gly Lys Pro Ile Pro   Thr Ile Gln Trp Ile   Lys Gly Asp 
    23495                 23500                 23505             


Gln Glu   Leu Ser Asn Thr Ala   Arg Leu Glu Ile Lys   Ser Thr Asp 
    23510                 23515                 23520             


Phe Ala   Thr Ser Leu Ser Val   Lys Asp Ala Val Arg   Val Asp Ser 
    23525                 23530                 23535             


Gly Asn   Tyr Ile Leu Lys Ala   Lys Asn Val Ala Gly   Glu Arg Ser 
    23540                 23545                 23550             


Val Thr   Val Asn Val Lys Val   Leu Asp Arg Pro Gly   Pro Pro Glu 
    23555                 23560                 23565             


Gly Pro   Val Val Ile Ser Gly   Val Thr Ala Glu Lys   Cys Thr Leu 
    23570                 23575                 23580             


Ala Trp   Lys Pro Pro Leu Gln   Asp Gly Gly Ser Asp   Ile Ile Asn 
    23585                 23590                 23595             


Tyr Ile   Val Glu Arg Arg Glu   Thr Ser Arg Leu Val   Trp Thr Val 
    23600                 23605                 23610             


Val Asp   Ala Asn Val Gln Thr   Leu Ser Cys Lys Val   Thr Lys Leu 
    23615                 23620                 23625             


Leu Glu   Gly Asn Glu Tyr Thr   Phe Arg Ile Met Ala   Val Asn Lys 
    23630                 23635                 23640             


Tyr Gly   Val Gly Glu Pro Leu   Glu Ser Glu Pro Val   Val Ala Lys 
    23645                 23650                 23655             


Asn Pro   Phe Val Val Pro Asp   Ala Pro Lys Ala Pro   Glu Val Thr 
    23660                 23665                 23670             


Thr Val   Thr Lys Asp Ser Met   Ile Val Val Trp Glu   Arg Pro Ala 
    23675                 23680                 23685             


Ser Asp   Gly Gly Ser Glu Ile   Leu Gly Tyr Val Leu   Glu Lys Arg 
    23690                 23695                 23700             


Asp Lys   Glu Gly Ile Arg Trp   Thr Arg Cys His Lys   Arg Leu Ile 
    23705                 23710                 23715             


Gly Glu   Leu Arg Leu Arg Val   Thr Gly Leu Ile Glu   Asn His Asp 
    23720                 23725                 23730             


Tyr Glu   Phe Arg Val Ser Ala   Glu Asn Ala Ala Gly   Leu Ser Glu 
    23735                 23740                 23745             


Pro Ser   Pro Pro Ser Ala Tyr   Gln Lys Ala Cys Asp   Pro Ile Tyr 
    23750                 23755                 23760             


Lys Pro   Gly Pro Pro Asn Asn   Pro Lys Val Ile Asp   Ile Thr Arg 
    23765                 23770                 23775             


Ser Ser   Val Phe Leu Ser Trp   Ser Lys Pro Ile Tyr   Asp Gly Gly 
    23780                 23785                 23790             


Cys Glu   Ile Gln Gly Tyr Ile   Val Glu Lys Cys Asp   Val Ser Val 
    23795                 23800                 23805             


Gly Glu   Trp Thr Met Cys Thr   Pro Pro Thr Gly Ile   Asn Lys Thr 
    23810                 23815                 23820             


Asn Ile   Glu Val Glu Lys Leu   Leu Glu Lys His Glu   Tyr Asn Phe 
    23825                 23830                 23835             


Arg Ile   Cys Ala Ile Asn Lys   Ala Gly Val Gly Glu   His Ala Asp 
    23840                 23845                 23850             


Val Pro   Gly Pro Ile Ile Val   Glu Glu Lys Leu Glu   Ala Pro Asp 
    23855                 23860                 23865             


Ile Asp   Leu Asp Leu Glu Leu   Arg Lys Ile Ile Asn   Ile Arg Ala 
    23870                 23875                 23880             


Gly Gly   Ser Leu Arg Leu Phe   Val Pro Ile Lys Gly   Arg Pro Thr 
    23885                 23890                 23895             


Pro Glu   Val Lys Trp Gly Lys   Val Asp Gly Glu Ile   Arg Asp Ala 
    23900                 23905                 23910             


Ala Ile   Ile Asp Val Thr Ser   Ser Phe Thr Ser Leu   Val Leu Asp 
    23915                 23920                 23925             


Asn Val   Asn Arg Tyr Asp Ser   Gly Lys Tyr Thr Leu   Thr Leu Glu 
    23930                 23935                 23940             


Asn Ser   Ser Gly Thr Lys Ser   Ala Phe Val Thr Val   Arg Val Leu 
    23945                 23950                 23955             


Asp Thr   Pro Ser Pro Pro Val   Asn Leu Lys Val Thr   Glu Ile Thr 
    23960                 23965                 23970             


Lys Asp   Ser Val Ser Ile Thr   Trp Glu Pro Pro Leu   Leu Asp Gly 
    23975                 23980                 23985             


Gly Ser   Lys Ile Lys Asn Tyr   Ile Val Glu Lys Arg   Glu Ala Thr 
    23990                 23995                 24000             


Arg Lys   Ser Tyr Ala Ala Val   Val Thr Asn Cys His   Lys Asn Ser 
    24005                 24010                 24015             


Trp Lys   Ile Asp Gln Leu Gln   Glu Gly Cys Ser Tyr   Tyr Phe Arg 
    24020                 24025                 24030             


Val Thr   Ala Glu Asn Glu Tyr   Gly Ile Gly Leu Pro   Ala Gln Thr 
    24035                 24040                 24045             


Ala Asp   Pro Ile Lys Val Ala   Glu Val Pro Gln Pro   Pro Gly Lys 
    24050                 24055                 24060             


Ile Thr   Val Asp Asp Val Thr   Arg Asn Ser Val Ser   Leu Ser Trp 
    24065                 24070                 24075             


Thr Lys   Pro Glu His Asp Gly   Gly Ser Lys Ile Ile   Gln Tyr Ile 
    24080                 24085                 24090             


Val Glu   Met Gln Ala Lys His   Ser Glu Lys Trp Ser   Glu Cys Ala 
    24095                 24100                 24105             


Arg Val   Lys Ser Leu Gln Ala   Val Ile Thr Asn Leu   Thr Gln Gly 
    24110                 24115                 24120             


Glu Glu   Tyr Leu Phe Arg Val   Val Ala Val Asn Glu   Lys Gly Arg 
    24125                 24130                 24135             


Ser Asp   Pro Arg Ser Leu Ala   Val Pro Ile Val Ala   Lys Asp Leu 
    24140                 24145                 24150             


Val Ile   Glu Pro Asp Val Lys   Pro Ala Phe Ser Ser   Tyr Ser Val 
    24155                 24160                 24165             


Gln Val   Gly Gln Asp Leu Lys   Ile Glu Val Pro Ile   Ser Gly Arg 
    24170                 24175                 24180             


Pro Lys   Pro Thr Ile Thr Trp   Thr Lys Asp Gly Leu   Pro Leu Lys 
    24185                 24190                 24195             


Gln Thr   Thr Arg Ile Asn Val   Thr Asp Ser Leu Asp   Leu Thr Thr 
    24200                 24205                 24210             


Leu Ser   Ile Lys Glu Thr His   Lys Asp Asp Gly Gly   Gln Tyr Gly 
    24215                 24220                 24225             


Ile Thr   Val Ala Asn Val Val   Gly Gln Lys Thr Ala   Ser Ile Glu 
    24230                 24235                 24240             


Ile Val   Thr Leu Asp Lys Pro   Asp Pro Pro Lys Gly   Pro Val Lys 
    24245                 24250                 24255             


Phe Asp   Asp Val Ser Ala Glu   Ser Ile Thr Leu Ser   Trp Asn Pro 
    24260                 24265                 24270             


Pro Leu   Tyr Thr Gly Gly Cys   Gln Ile Thr Asn Tyr   Ile Val Gln 
    24275                 24280                 24285             


Lys Arg   Asp Thr Thr Thr Thr   Val Trp Asp Val Val   Ser Ala Thr 
    24290                 24295                 24300             


Val Ala   Arg Thr Thr Leu Lys   Val Thr Lys Leu Lys   Thr Gly Thr 
    24305                 24310                 24315             


Glu Tyr   Gln Phe Arg Ile Phe   Ala Glu Asn Arg Tyr   Gly Gln Ser 
    24320                 24325                 24330             


Phe Ala   Leu Glu Ser Asp Pro   Ile Val Ala Gln Tyr   Pro Tyr Lys 
    24335                 24340                 24345             


Glu Pro   Gly Pro Pro Gly Thr   Pro Phe Ala Thr Ala   Ile Ser Lys 
    24350                 24355                 24360             


Asp Ser   Met Val Ile Gln Trp   His Glu Pro Val Asn   Asn Gly Gly 
    24365                 24370                 24375             


Ser Pro   Val Ile Gly Tyr His   Leu Glu Arg Lys Glu   Arg Asn Ser 
    24380                 24385                 24390             


Ile Leu   Trp Thr Lys Val Asn   Lys Thr Ile Ile His   Asp Thr Gln 
    24395                 24400                 24405             


Phe Lys   Ala Gln Asn Leu Glu   Glu Gly Ile Glu Tyr   Glu Phe Arg 
    24410                 24415                 24420             


Val Tyr   Ala Glu Asn Ile Val   Gly Val Gly Lys Ala   Ser Lys Asn 
    24425                 24430                 24435             


Ser Glu   Cys Tyr Val Ala Arg   Asp Pro Cys Asp Pro   Pro Gly Thr 
    24440                 24445                 24450             


Pro Glu   Pro Ile Met Val Lys   Arg Asn Glu Ile Thr   Leu Gln Trp 
    24455                 24460                 24465             


Thr Lys   Pro Val Tyr Asp Gly   Gly Ser Met Ile Thr   Gly Tyr Ile 
    24470                 24475                 24480             


Val Glu   Lys Arg Asp Leu Pro   Asp Gly Arg Trp Met   Lys Ala Ser 
    24485                 24490                 24495             


Phe Thr   Asn Val Ile Glu Thr   Gln Phe Thr Val Ser   Gly Leu Thr 
    24500                 24505                 24510             


Glu Asp   Gln Arg Tyr Glu Phe   Arg Val Ile Ala Lys   Asn Ala Ala 
    24515                 24520                 24525             


Gly Ala   Ile Ser Lys Pro Ser   Asp Ser Thr Gly Pro   Ile Thr Ala 
    24530                 24535                 24540             


Lys Asp   Glu Val Glu Leu Pro   Arg Ile Ser Met Asp   Pro Lys Phe 
    24545                 24550                 24555             


Arg Asp   Thr Ile Val Val Asn   Ala Gly Glu Thr Phe   Arg Leu Glu 
    24560                 24565                 24570             


Ala Asp   Val His Gly Lys Pro   Leu Pro Thr Ile Glu   Trp Leu Arg 
    24575                 24580                 24585             


Gly Asp   Lys Glu Ile Glu Glu   Ser Ala Arg Cys Glu   Ile Lys Asn 
    24590                 24595                 24600             


Thr Asp   Phe Lys Ala Leu Leu   Ile Val Lys Asp Ala   Ile Arg Ile 
    24605                 24610                 24615             


Asp Gly   Gly Gln Tyr Ile Leu   Arg Ala Ser Asn Val   Ala Gly Ser 
    24620                 24625                 24630             


Lys Ser   Phe Pro Val Asn Val   Lys Val Leu Asp Arg   Pro Gly Pro 
    24635                 24640                 24645             


Pro Glu   Gly Pro Val Gln Val   Thr Gly Val Thr Ser   Glu Lys Cys 
    24650                 24655                 24660             


Ser Leu   Thr Trp Ser Pro Pro   Leu Gln Asp Gly Gly   Ser Asp Ile 
    24665                 24670                 24675             


Ser His   Tyr Val Val Glu Lys   Arg Glu Thr Ser Arg   Leu Ala Trp 
    24680                 24685                 24690             


Thr Val   Val Ala Ser Glu Val   Val Thr Asn Ser Leu   Lys Val Thr 
    24695                 24700                 24705             


Lys Leu   Leu Glu Gly Asn Glu   Tyr Val Phe Arg Ile   Met Ala Val 
    24710                 24715                 24720             


Asn Lys   Tyr Gly Val Gly Glu   Pro Leu Glu Ser Ala   Pro Val Leu 
    24725                 24730                 24735             


Met Lys   Asn Pro Phe Val Leu   Pro Gly Pro Pro Lys   Ser Leu Glu 
    24740                 24745                 24750             


Val Thr   Asn Ile Ala Lys Asp   Ser Met Thr Val Cys   Trp Asn Arg 
    24755                 24760                 24765             


Pro Asp   Ser Asp Gly Gly Ser   Glu Ile Ile Gly Tyr   Ile Val Glu 
    24770                 24775                 24780             


Lys Arg   Asp Arg Ser Gly Ile   Arg Trp Ile Lys Cys   Asn Lys Arg 
    24785                 24790                 24795             


Arg Ile   Thr Asp Leu Arg Leu   Arg Val Thr Gly Leu   Thr Glu Asp 
    24800                 24805                 24810             


His Glu   Tyr Glu Phe Arg Val   Ser Ala Glu Asn Ala   Ala Gly Val 
    24815                 24820                 24825             


Gly Glu   Pro Ser Pro Ala Thr   Val Tyr Tyr Lys Ala   Cys Asp Pro 
    24830                 24835                 24840             


Val Phe   Lys Pro Gly Pro Pro   Thr Asn Ala His Ile   Val Asp Thr 
    24845                 24850                 24855             


Thr Lys   Asn Ser Ile Thr Leu   Ala Trp Gly Lys Pro   Ile Tyr Asp 
    24860                 24865                 24870             


Gly Gly   Ser Glu Ile Leu Gly   Tyr Val Val Glu Ile   Cys Lys Ala 
    24875                 24880                 24885             


Asp Glu   Glu Glu Trp Gln Ile   Val Thr Pro Gln Thr   Gly Leu Arg 
    24890                 24895                 24900             


Val Thr   Arg Phe Glu Ile Ser   Lys Leu Thr Glu His   Gln Glu Tyr 
    24905                 24910                 24915             


Lys Ile   Arg Val Cys Ala Leu   Asn Lys Val Gly Leu   Gly Glu Ala 
    24920                 24925                 24930             


Thr Ser   Val Pro Gly Thr Val   Lys Pro Glu Asp Lys   Leu Glu Ala 
    24935                 24940                 24945             


Pro Glu   Leu Asp Leu Asp Ser   Glu Leu Arg Lys Gly   Ile Val Val 
    24950                 24955                 24960             


Arg Ala   Gly Gly Ser Ala Arg   Ile His Ile Pro Phe   Lys Gly Arg 
    24965                 24970                 24975             


Pro Thr   Pro Glu Ile Thr Trp   Ser Arg Glu Glu Gly   Glu Phe Thr 
    24980                 24985                 24990             


Asp Lys   Val Gln Ile Glu Lys   Gly Val Asn Tyr Thr   Gln Leu Ser 
    24995                 25000                 25005             


Ile Asp   Asn Cys Asp Arg Asn   Asp Ala Gly Lys Tyr   Ile Leu Lys 
    25010                 25015                 25020             


Leu Glu   Asn Ser Ser Gly Ser   Lys Ser Ala Phe Val   Thr Val Lys 
    25025                 25030                 25035             


Val Leu   Asp Thr Pro Gly Pro   Pro Gln Asn Leu Ala   Val Lys Glu 
    25040                 25045                 25050             


Val Arg   Lys Asp Ser Ala Phe   Leu Val Trp Glu Pro   Pro Ile Ile 
    25055                 25060                 25065             


Asp Gly   Gly Ala Lys Val Lys   Asn Tyr Val Ile Asp   Lys Arg Glu 
    25070                 25075                 25080             


Ser Thr   Arg Lys Ala Tyr Ala   Asn Val Ser Ser Lys   Cys Ser Lys 
    25085                 25090                 25095             


Thr Ser   Phe Lys Val Glu Asn   Leu Thr Glu Gly Ala   Ile Tyr Tyr 
    25100                 25105                 25110             


Phe Arg   Val Met Ala Glu Asn   Glu Phe Gly Val Gly   Val Pro Val 
    25115                 25120                 25125             


Glu Thr   Val Asp Ala Val Lys   Ala Ala Glu Pro Pro   Ser Pro Pro 
    25130                 25135                 25140             


Gly Lys   Val Thr Leu Thr Asp   Val Ser Gln Thr Ser   Ala Ser Leu 
    25145                 25150                 25155             


Met Trp   Glu Lys Pro Glu His   Asp Gly Gly Ser Arg   Val Leu Gly 
    25160                 25165                 25170             


Tyr Val   Val Glu Met Gln Pro   Lys Gly Thr Glu Lys   Trp Ser Ile 
    25175                 25180                 25185             


Val Ala   Glu Ser Lys Val Cys   Asn Ala Val Val Thr   Gly Leu Ser 
    25190                 25195                 25200             


Ser Gly   Gln Glu Tyr Gln Phe   Arg Val Lys Ala Tyr   Asn Glu Lys 
    25205                 25210                 25215             


Gly Lys   Ser Asp Pro Arg Val   Leu Gly Val Pro Val   Ile Ala Lys 
    25220                 25225                 25230             


Asp Leu   Thr Ile Gln Pro Ser   Leu Lys Leu Pro Phe   Asn Thr Tyr 
    25235                 25240                 25245             


Ser Ile   Gln Ala Gly Glu Asp   Leu Lys Ile Glu Ile   Pro Val Ile 
    25250                 25255                 25260             


Gly Arg   Pro Arg Pro Asn Ile   Ser Trp Val Lys Asp   Gly Glu Pro 
    25265                 25270                 25275             


Leu Lys   Gln Thr Thr Arg Val   Asn Val Glu Glu Thr   Ala Thr Ser 
    25280                 25285                 25290             


Thr Val   Leu His Ile Lys Glu   Gly Asn Lys Asp Asp   Phe Gly Lys 
    25295                 25300                 25305             


Tyr Thr   Val Thr Ala Thr Asn   Ser Ala Gly Thr Ala   Thr Glu Asn 
    25310                 25315                 25320             


Leu Ser   Val Ile Val Leu Glu   Lys Pro Gly Pro Pro   Val Gly Pro 
    25325                 25330                 25335             


Val Arg   Phe Asp Glu Val Ser   Ala Asp Phe Val Val   Ile Ser Trp 
    25340                 25345                 25350             


Glu Pro   Pro Ala Tyr Thr Gly   Gly Cys Gln Ile Ser   Asn Tyr Ile 
    25355                 25360                 25365             


Val Glu   Lys Arg Asp Thr Thr   Thr Thr Thr Trp His   Met Val Ser 
    25370                 25375                 25380             


Ala Thr   Val Ala Arg Thr Thr   Ile Lys Ile Thr Lys   Leu Lys Thr 
    25385                 25390                 25395             


Gly Thr   Glu Tyr Gln Phe Arg   Ile Phe Ala Glu Asn   Arg Tyr Gly 
    25400                 25405                 25410             


Lys Ser   Ala Pro Leu Asp Ser   Lys Ala Val Ile Val   Gln Tyr Pro 
    25415                 25420                 25425             


Phe Lys   Glu Pro Gly Pro Pro   Gly Thr Pro Phe Val   Thr Ser Ile 
    25430                 25435                 25440             


Ser Lys   Asp Gln Met Leu Val   Gln Trp His Glu Pro   Val Asn Asp 
    25445                 25450                 25455             


Gly Gly   Thr Lys Ile Ile Gly   Tyr His Leu Glu Gln   Lys Glu Lys 
    25460                 25465                 25470             


Asn Ser   Ile Leu Trp Val Lys   Leu Asn Lys Thr Pro   Ile Gln Asp 
    25475                 25480                 25485             


Thr Lys   Phe Lys Thr Thr Gly   Leu Asp Glu Gly Leu   Glu Tyr Glu 
    25490                 25495                 25500             


Phe Lys   Val Ser Ala Glu Asn   Ile Val Gly Ile Gly   Lys Pro Ser 
    25505                 25510                 25515             


Lys Val   Ser Glu Cys Phe Val   Ala Arg Asp Pro Cys   Asp Pro Pro 
    25520                 25525                 25530             


Gly Arg   Pro Glu Ala Ile Val   Ile Thr Arg Asn Asn   Val Thr Leu 
    25535                 25540                 25545             


Lys Trp   Lys Lys Pro Ala Tyr   Asp Gly Gly Ser Lys   Ile Thr Gly 
    25550                 25555                 25560             


Tyr Ile   Val Glu Lys Lys Asp   Leu Pro Asp Gly Arg   Trp Met Lys 
    25565                 25570                 25575             


Ala Ser   Phe Thr Asn Val Leu   Glu Thr Glu Phe Thr   Val Ser Gly 
    25580                 25585                 25590             


Leu Val   Glu Asp Gln Arg Tyr   Glu Phe Arg Val Ile   Ala Arg Asn 
    25595                 25600                 25605             


Ala Ala   Gly Asn Phe Ser Glu   Pro Ser Asp Ser Ser   Gly Ala Ile 
    25610                 25615                 25620             


Thr Ala   Arg Asp Glu Ile Asp   Ala Pro Asn Ala Ser   Leu Asp Pro 
    25625                 25630                 25635             


Lys Tyr   Lys Asp Val Ile Val   Val His Ala Gly Glu   Thr Phe Val 
    25640                 25645                 25650             


Leu Glu   Ala Asp Ile Arg Gly   Lys Pro Ile Pro Asp   Val Val Trp 
    25655                 25660                 25665             


Ser Lys   Asp Gly Lys Glu Leu   Glu Glu Thr Ala Ala   Arg Met Glu 
    25670                 25675                 25680             


Ile Lys   Ser Thr Ile Gln Lys   Thr Thr Leu Val Val   Lys Asp Cys 
    25685                 25690                 25695             


Ile Arg   Thr Asp Gly Gly Gln   Tyr Ile Leu Lys Leu   Ser Asn Val 
    25700                 25705                 25710             


Gly Gly   Thr Lys Ser Ile Pro   Ile Thr Val Lys Val   Leu Asp Arg 
    25715                 25720                 25725             


Pro Gly   Pro Pro Glu Gly Pro   Leu Lys Val Thr Gly   Val Thr Ala 
    25730                 25735                 25740             


Glu Lys   Cys Tyr Leu Ala Trp   Asn Pro Pro Leu Gln   Asp Gly Gly 
    25745                 25750                 25755             


Ala Asn   Ile Ser His Tyr Ile   Ile Glu Lys Arg Glu   Thr Ser Arg 
    25760                 25765                 25770             


Leu Ser   Trp Thr Gln Val Ser   Thr Glu Val Gln Ala   Leu Asn Tyr 
    25775                 25780                 25785             


Lys Val   Thr Lys Leu Leu Pro   Gly Asn Glu Tyr Ile   Phe Arg Val 
    25790                 25795                 25800             


Met Ala   Val Asn Lys Tyr Gly   Ile Gly Glu Pro Leu   Glu Ser Gly 
    25805                 25810                 25815             


Pro Val   Thr Ala Cys Asn Pro   Tyr Lys Pro Pro Gly   Pro Pro Ser 
    25820                 25825                 25830             


Thr Pro   Glu Val Ser Ala Ile   Thr Lys Asp Ser Met   Val Val Thr 
    25835                 25840                 25845             


Trp Ala   Arg Pro Val Asp Asp   Gly Gly Thr Glu Ile   Glu Gly Tyr 
    25850                 25855                 25860             


Ile Leu   Glu Lys Arg Asp Lys   Glu Gly Val Arg Trp   Thr Lys Cys 
    25865                 25870                 25875             


Asn Lys   Lys Thr Leu Thr Asp   Leu Arg Leu Arg Val   Thr Gly Leu 
    25880                 25885                 25890             


Thr Glu   Gly His Ser Tyr Glu   Phe Arg Val Ala Ala   Glu Asn Ala 
    25895                 25900                 25905             


Ala Gly   Val Gly Glu Pro Ser   Glu Pro Ser Val Phe   Tyr Arg Ala 
    25910                 25915                 25920             


Cys Asp   Ala Leu Tyr Pro Pro   Gly Pro Pro Ser Asn   Pro Lys Val 
    25925                 25930                 25935             


Thr Asp   Thr Ser Arg Ser Ser   Val Ser Leu Ala Trp   Ser Lys Pro 
    25940                 25945                 25950             


Ile Tyr   Asp Gly Gly Ala Pro   Val Lys Gly Tyr Val   Val Glu Val 
    25955                 25960                 25965             


Lys Glu   Ala Ala Ala Asp Glu   Trp Thr Thr Cys Thr   Pro Pro Thr 
    25970                 25975                 25980             


Gly Leu   Gln Gly Lys Gln Phe   Thr Val Thr Lys Leu   Lys Glu Asn 
    25985                 25990                 25995             


Thr Glu   Tyr Asn Phe Arg Ile   Cys Ala Ile Asn Ser   Glu Gly Val 
    26000                 26005                 26010             


Gly Glu   Pro Ala Thr Leu Pro   Gly Ser Val Val Ala   Gln Glu Arg 
    26015                 26020                 26025             


Ile Glu   Pro Pro Glu Ile Glu   Leu Asp Ala Asp Leu   Arg Lys Val 
    26030                 26035                 26040             


Val Val   Leu Arg Ala Ser Ala   Thr Leu Arg Leu Phe   Val Thr Ile 
    26045                 26050                 26055             


Lys Gly   Arg Pro Glu Pro Glu   Val Lys Trp Glu Lys   Ala Glu Gly 
    26060                 26065                 26070             


Ile Leu   Thr Asp Arg Ala Gln   Ile Glu Val Thr Ser   Ser Phe Thr 
    26075                 26080                 26085             


Met Leu   Val Ile Asp Asn Val   Thr Arg Phe Asp Ser   Gly Arg Tyr 
    26090                 26095                 26100             


Asn Leu   Thr Leu Glu Asn Asn   Ser Gly Ser Lys Thr   Ala Phe Val 
    26105                 26110                 26115             


Asn Val   Arg Val Leu Asp Ser   Pro Ser Ala Pro Val   Asn Leu Thr 
    26120                 26125                 26130             


Ile Arg   Glu Val Lys Lys Asp   Ser Val Thr Leu Ser   Trp Glu Pro 
    26135                 26140                 26145             


Pro Leu   Ile Asp Gly Gly Ala   Lys Ile Thr Asn Tyr   Ile Val Glu 
    26150                 26155                 26160             


Lys Arg   Glu Thr Thr Arg Lys   Ala Tyr Ala Thr Ile   Thr Asn Asn 
    26165                 26170                 26175             


Cys Thr   Lys Thr Thr Phe Arg   Ile Glu Asn Leu Gln   Glu Gly Cys 
    26180                 26185                 26190             


Ser Tyr   Tyr Phe Arg Val Leu   Ala Ser Asn Glu Tyr   Gly Ile Gly 
    26195                 26200                 26205             


Leu Pro   Ala Glu Thr Thr Glu   Pro Val Lys Val Ser   Glu Pro Pro 
    26210                 26215                 26220             


Leu Pro   Pro Gly Arg Val Thr   Leu Val Asp Val Thr   Arg Asn Thr 
    26225                 26230                 26235             


Ala Thr   Ile Lys Trp Glu Lys   Pro Glu Ser Asp Gly   Gly Ser Lys 
    26240                 26245                 26250             


Ile Thr   Gly Tyr Val Val Glu   Met Gln Thr Lys Gly   Ser Glu Lys 
    26255                 26260                 26265             


Trp Ser   Thr Cys Thr Gln Val   Lys Thr Leu Glu Ala   Thr Ile Ser 
    26270                 26275                 26280             


Gly Leu   Thr Ala Gly Glu Glu   Tyr Val Phe Arg Val   Ala Ala Val 
    26285                 26290                 26295             


Asn Glu   Lys Gly Arg Ser Asp   Pro Arg Gln Leu Gly   Val Pro Val 
    26300                 26305                 26310             


Ile Ala   Arg Asp Ile Glu Ile   Lys Pro Ser Val Glu   Leu Pro Phe 
    26315                 26320                 26325             


His Thr   Phe Asn Val Lys Ala   Arg Glu Gln Leu Lys   Ile Asp Val 
    26330                 26335                 26340             


Pro Phe   Lys Gly Arg Pro Gln   Ala Thr Val Asn Trp   Arg Lys Asp 
    26345                 26350                 26355             


Gly Gln   Thr Leu Lys Glu Thr   Thr Arg Val Asn Val   Ser Ser Ser 
    26360                 26365                 26370             


Lys Thr   Val Thr Ser Leu Ser   Ile Lys Glu Ala Ser   Lys Glu Asp 
    26375                 26380                 26385             


Val Gly   Thr Tyr Glu Leu Cys   Val Ser Asn Ser Ala   Gly Ser Ile 
    26390                 26395                 26400             


Thr Val   Pro Ile Thr Ile Ile   Val Leu Asp Arg Pro   Gly Pro Pro 
    26405                 26410                 26415             


Gly Pro   Ile Arg Ile Asp Glu   Val Ser Cys Asp Ser   Ile Thr Ile 
    26420                 26425                 26430             


Ser Trp   Asn Pro Pro Glu Tyr   Asp Gly Gly Cys Gln   Ile Ser Asn 
    26435                 26440                 26445             


Tyr Ile   Val Glu Lys Lys Glu   Thr Thr Ser Thr Thr   Trp His Ile 
    26450                 26455                 26460             


Val Ser   Gln Ala Val Ala Arg   Thr Ser Ile Lys Ile   Val Arg Leu 
    26465                 26470                 26475             


Thr Thr   Gly Ser Glu Tyr Gln   Phe Arg Val Cys Ala   Glu Asn Arg 
    26480                 26485                 26490             


Tyr Gly   Lys Ser Ser Tyr Ser   Glu Ser Ser Ala Val   Val Ala Glu 
    26495                 26500                 26505             


Tyr Pro   Phe Ser Pro Pro Gly   Pro Pro Gly Thr Pro   Lys Val Val 
    26510                 26515                 26520             


His Ala   Thr Lys Ser Thr Met   Leu Val Thr Trp Gln   Val Pro Val 
    26525                 26530                 26535             


Asn Asp   Gly Gly Ser Arg Val   Ile Gly Tyr His Leu   Glu Tyr Lys 
    26540                 26545                 26550             


Glu Arg   Ser Ser Ile Leu Trp   Ser Lys Ala Asn Lys   Ile Leu Ile 
    26555                 26560                 26565             


Ala Asp   Thr Gln Met Lys Val   Ser Gly Leu Asp Glu   Gly Leu Met 
    26570                 26575                 26580             


Tyr Glu   Tyr Arg Val Tyr Ala   Glu Asn Ile Ala Gly   Ile Gly Lys 
    26585                 26590                 26595             


Cys Ser   Lys Ser Cys Glu Pro   Val Pro Ala Arg Asp   Pro Cys Asp 
    26600                 26605                 26610             


Pro Pro   Gly Gln Pro Glu Val   Thr Asn Ile Thr Arg   Lys Ser Val 
    26615                 26620                 26625             


Ser Leu   Lys Trp Ser Lys Pro   His Tyr Asp Gly Gly   Ala Lys Ile 
    26630                 26635                 26640             


Thr Gly   Tyr Ile Val Glu Arg   Arg Glu Leu Pro Asp   Gly Arg Trp 
    26645                 26650                 26655             


Leu Lys   Cys Asn Tyr Thr Asn   Ile Gln Glu Thr Tyr   Phe Glu Val 
    26660                 26665                 26670             


Thr Glu   Leu Thr Glu Asp Gln   Arg Tyr Glu Phe Arg   Val Phe Ala 
    26675                 26680                 26685             


Arg Asn   Ala Ala Asp Ser Val   Ser Glu Pro Ser Glu   Ser Thr Gly 
    26690                 26695                 26700             


Pro Ile   Ile Val Lys Asp Asp   Val Glu Pro Pro Arg   Val Met Met 
    26705                 26710                 26715             


Asp Val   Lys Phe Arg Asp Val   Ile Val Val Lys Ala   Gly Glu Val 
    26720                 26725                 26730             


Leu Lys   Ile Asn Ala Asp Ile   Ala Gly Arg Pro Leu   Pro Val Ile 
    26735                 26740                 26745             


Ser Trp   Ala Lys Asp Gly Ile   Glu Ile Glu Glu Arg   Ala Arg Thr 
    26750                 26755                 26760             


Glu Ile   Ile Ser Thr Asp Asn   His Thr Leu Leu Thr   Val Lys Asp 
    26765                 26770                 26775             


Cys Ile   Arg Arg Asp Thr Gly   Gln Tyr Val Leu Thr   Leu Lys Asn 
    26780                 26785                 26790             


Val Ala   Gly Thr Arg Ser Val   Ala Val Asn Cys Lys   Val Leu Asp 
    26795                 26800                 26805             


Lys Pro   Gly Pro Pro Ala Gly   Pro Leu Glu Ile Asn   Gly Leu Thr 
    26810                 26815                 26820             


Ala Glu   Lys Cys Ser Leu Ser   Trp Gly Arg Pro Gln   Glu Asp Gly 
    26825                 26830                 26835             


Gly Ala   Asp Ile Asp Tyr Tyr   Ile Val Glu Lys Arg   Glu Thr Ser 
    26840                 26845                 26850             


His Leu   Ala Trp Thr Ile Cys   Glu Gly Glu Leu Gln   Met Thr Ser 
    26855                 26860                 26865             


Cys Lys   Val Thr Lys Leu Leu   Lys Gly Asn Glu Tyr   Ile Phe Arg 
    26870                 26875                 26880             


Val Thr   Gly Val Asn Lys Tyr   Gly Val Gly Glu Pro   Leu Glu Ser 
    26885                 26890                 26895             


Val Ala   Ile Lys Ala Leu Asp   Pro Phe Thr Val Pro   Ser Pro Pro 
    26900                 26905                 26910             


Thr Ser   Leu Glu Ile Thr Ser   Val Thr Lys Glu Ser   Met Thr Leu 
    26915                 26920                 26925             


Cys Trp   Ser Arg Pro Glu Ser   Asp Gly Gly Ser Glu   Ile Ser Gly 
    26930                 26935                 26940             


Tyr Ile   Ile Glu Arg Arg Glu   Lys Asn Ser Leu Arg   Trp Val Arg 
    26945                 26950                 26955             


Val Asn   Lys Lys Pro Val Tyr   Asp Leu Arg Val Lys   Ser Thr Gly 
    26960                 26965                 26970             


Leu Arg   Glu Gly Cys Glu Tyr   Glu Tyr Arg Val Tyr   Ala Glu Asn 
    26975                 26980                 26985             


Ala Ala   Gly Leu Ser Leu Pro   Ser Glu Thr Ser Pro   Leu Ile Arg 
    26990                 26995                 27000             


Ala Glu   Asp Pro Val Phe Leu   Pro Ser Pro Pro Ser   Lys Pro Lys 
    27005                 27010                 27015             


Ile Val   Asp Ser Gly Lys Thr   Thr Ile Thr Ile Ala   Trp Val Lys 
    27020                 27025                 27030             


Pro Leu   Phe Asp Gly Gly Ala   Pro Ile Thr Gly Tyr   Thr Val Glu 
    27035                 27040                 27045             


Tyr Lys   Lys Ser Asp Asp Thr   Asp Trp Lys Thr Ser   Ile Gln Ser 
    27050                 27055                 27060             


Leu Arg   Gly Thr Glu Tyr Thr   Ile Ser Gly Leu Thr   Thr Gly Ala 
    27065                 27070                 27075             


Glu Tyr   Val Phe Arg Val Lys   Ser Val Asn Lys Val   Gly Ala Ser 
    27080                 27085                 27090             


Asp Pro   Ser Asp Ser Ser Asp   Pro Gln Ile Ala Lys   Glu Arg Glu 
    27095                 27100                 27105             


Glu Glu   Pro Leu Phe Asp Ile   Asp Ser Glu Met Arg   Lys Thr Leu 
    27110                 27115                 27120             


Ile Val   Lys Ala Gly Ala Ser   Phe Thr Met Thr Val   Pro Phe Arg 
    27125                 27130                 27135             


Gly Arg   Pro Val Pro Asn Val   Leu Trp Ser Lys Pro   Asp Thr Asp 
    27140                 27145                 27150             


Leu Arg   Thr Arg Ala Tyr Val   Asp Thr Thr Asp Ser   Arg Thr Ser 
    27155                 27160                 27165             


Leu Thr   Ile Glu Asn Ala Asn   Arg Asn Asp Ser Gly   Lys Tyr Thr 
    27170                 27175                 27180             


Leu Thr   Ile Gln Asn Val Leu   Ser Ala Ala Ser Leu   Thr Leu Val 
    27185                 27190                 27195             


Val Lys   Val Leu Asp Thr Pro   Gly Pro Pro Thr Asn   Ile Thr Val 
    27200                 27205                 27210             


Gln Asp   Val Thr Lys Glu Ser   Ala Val Leu Ser Trp   Asp Val Pro 
    27215                 27220                 27225             


Glu Asn   Asp Gly Gly Ala Pro   Val Lys Asn Tyr His   Ile Glu Lys 
    27230                 27235                 27240             


Arg Glu   Ala Ser Lys Lys Ala   Trp Val Ser Val Thr   Asn Asn Cys 
    27245                 27250                 27255             


Asn Arg   Leu Ser Tyr Lys Val   Thr Asn Leu Gln Glu   Gly Ala Ile 
    27260                 27265                 27270             


Tyr Tyr   Phe Arg Val Ser Gly   Glu Asn Glu Phe Gly   Val Gly Ile 
    27275                 27280                 27285             


Pro Ala   Glu Thr Lys Glu Gly   Val Lys Ile Thr Glu   Lys Pro Ser 
    27290                 27295                 27300             


Pro Pro   Glu Lys Leu Gly Val   Thr Ser Ile Ser Lys   Asp Ser Val 
    27305                 27310                 27315             


Ser Leu   Thr Trp Leu Lys Pro   Glu His Asp Gly Gly   Ser Arg Ile 
    27320                 27325                 27330             


Val His   Tyr Val Val Glu Ala   Leu Glu Lys Gly Gln   Lys Asn Trp 
    27335                 27340                 27345             


Val Lys   Cys Ala Val Ala Lys   Ser Thr His His Val   Val Ser Gly 
    27350                 27355                 27360             


Leu Arg   Glu Asn Ser Glu Tyr   Phe Phe Arg Val Phe   Ala Glu Asn 
    27365                 27370                 27375             


Gln Ala   Gly Leu Ser Asp Pro   Arg Glu Leu Leu Leu   Pro Val Leu 
    27380                 27385                 27390             


Ile Lys   Glu Gln Leu Glu Pro   Pro Glu Ile Asp Met   Lys Asn Phe 
    27395                 27400                 27405             


Pro Ser   His Thr Val Tyr Val   Arg Ala Gly Ser Asn   Leu Lys Val 
    27410                 27415                 27420             


Asp Ile   Pro Ile Ser Gly Lys   Pro Leu Pro Lys Val   Thr Leu Ser 
    27425                 27430                 27435             


Arg Asp   Gly Val Pro Leu Lys   Ala Thr Met Arg Phe   Asn Thr Glu 
    27440                 27445                 27450             


Ile Thr   Ala Glu Asn Leu Thr   Ile Asn Leu Lys Glu   Ser Val Thr 
    27455                 27460                 27465             


Ala Asp   Ala Gly Arg Tyr Glu   Ile Thr Ala Ala Asn   Ser Ser Gly 
    27470                 27475                 27480             


Thr Thr   Lys Ala Phe Ile Asn   Ile Val Val Leu Asp   Arg Pro Gly 
    27485                 27490                 27495             


Pro Pro   Thr Gly Pro Val Val   Ile Ser Asp Ile Thr   Glu Glu Ser 
    27500                 27505                 27510             


Val Thr   Leu Lys Trp Glu Pro   Pro Lys Tyr Asp Gly   Gly Ser Gln 
    27515                 27520                 27525             


Val Thr   Asn Tyr Ile Leu Leu   Lys Arg Glu Thr Ser   Thr Ala Val 
    27530                 27535                 27540             


Trp Thr   Glu Val Ser Ala Thr   Val Ala Arg Thr Met   Met Lys Val 
    27545                 27550                 27555             


Met Lys   Leu Thr Thr Gly Glu   Glu Tyr Gln Phe Arg   Ile Lys Ala 
    27560                 27565                 27570             


Glu Asn   Arg Phe Gly Ile Ser   Asp His Ile Asp Ser   Ala Cys Val 
    27575                 27580                 27585             


Thr Val   Lys Leu Pro Tyr Thr   Thr Pro Gly Pro Pro   Ser Thr Pro 
    27590                 27595                 27600             


Trp Val   Thr Asn Val Thr Arg   Glu Ser Ile Thr Val   Gly Trp His 
    27605                 27610                 27615             


Glu Pro   Val Ser Asn Gly Gly   Ser Ala Val Val Gly   Tyr His Leu 
    27620                 27625                 27630             


Glu Met   Lys Asp Arg Asn Ser   Ile Leu Trp Gln Lys   Ala Asn Lys 
    27635                 27640                 27645             


Leu Val   Ile Arg Thr Thr His   Phe Lys Val Thr Thr   Ile Ser Ala 
    27650                 27655                 27660             


Gly Leu   Ile Tyr Glu Phe Arg   Val Tyr Ala Glu Asn   Ala Ala Gly 
    27665                 27670                 27675             


Val Gly   Lys Pro Ser His Pro   Ser Glu Pro Val Leu   Ala Ile Asp 
    27680                 27685                 27690             


Ala Cys   Glu Pro Pro Arg Asn   Val Arg Ile Thr Asp   Ile Ser Lys 
    27695                 27700                 27705             


Asn Ser   Val Ser Leu Ser Trp   Gln Gln Pro Ala Phe   Asp Gly Gly 
    27710                 27715                 27720             


Ser Lys   Ile Thr Gly Tyr Ile   Val Glu Arg Arg Asp   Leu Pro Asp 
    27725                 27730                 27735             


Gly Arg   Trp Thr Lys Ala Ser   Phe Thr Asn Val Thr   Glu Thr Gln 
    27740                 27745                 27750             


Phe Ile   Ile Ser Gly Leu Thr   Gln Asn Ser Gln Tyr   Glu Phe Arg 
    27755                 27760                 27765             


Val Phe   Ala Arg Asn Ala Val   Gly Ser Ile Ser Asn   Pro Ser Glu 
    27770                 27775                 27780             


Val Val   Gly Pro Ile Thr Cys   Ile Asp Ser Tyr Gly   Gly Pro Val 
    27785                 27790                 27795             


Ile Asp   Leu Pro Leu Glu Tyr   Thr Glu Val Val Lys   Tyr Arg Ala 
    27800                 27805                 27810             


Gly Thr   Ser Val Lys Leu Arg   Ala Gly Ile Ser Gly   Lys Pro Ala 
    27815                 27820                 27825             


Pro Thr   Ile Glu Trp Tyr Lys   Asp Asp Lys Glu Leu   Gln Thr Asn 
    27830                 27835                 27840             


Ala Leu   Val Cys Val Glu Asn   Thr Thr Asp Leu Ala   Ser Ile Leu 
    27845                 27850                 27855             


Ile Lys   Asp Ala Asp Arg Leu   Asn Ser Gly Cys Tyr   Glu Leu Lys 
    27860                 27865                 27870             


Leu Arg   Asn Ala Met Gly Ser   Ala Ser Ala Thr Ile   Arg Val Gln 
    27875                 27880                 27885             


Ile Leu   Asp Lys Pro Gly Pro   Pro Gly Gly Pro Ile   Glu Phe Lys 
    27890                 27895                 27900             


Thr Val   Thr Ala Glu Lys Ile   Thr Leu Leu Trp Arg   Pro Pro Ala 
    27905                 27910                 27915             


Asp Asp   Gly Gly Ala Lys Ile   Thr His Tyr Ile Val   Glu Lys Arg 
    27920                 27925                 27930             


Glu Thr   Ser Arg Val Val Trp   Ser Met Val Ser Glu   His Leu Glu 
    27935                 27940                 27945             


Glu Cys   Ile Ile Thr Thr Thr   Lys Ile Ile Lys Gly   Asn Glu Tyr 
    27950                 27955                 27960             


Ile Phe   Arg Val Arg Ala Val   Asn Lys Tyr Gly Ile   Gly Glu Pro 
    27965                 27970                 27975             


Leu Glu   Ser Asp Ser Val Val   Ala Lys Asn Ala Phe   Val Thr Pro 
    27980                 27985                 27990             


Gly Pro   Pro Gly Ile Pro Glu   Val Thr Lys Ile Thr   Lys Asn Ser 
    27995                 28000                 28005             


Met Thr   Val Val Trp Ser Arg   Pro Ile Ala Asp Gly   Gly Ser Asp 
    28010                 28015                 28020             


Ile Ser   Gly Tyr Phe Leu Glu   Lys Arg Asp Lys Lys   Ser Leu Gly 
    28025                 28030                 28035             


Trp Phe   Lys Val Leu Lys Glu   Thr Ile Arg Asp Thr   Arg Gln Lys 
    28040                 28045                 28050             


Val Thr   Gly Leu Thr Glu Asn   Ser Asp Tyr Gln Tyr   Arg Val Cys 
    28055                 28060                 28065             


Ala Val   Asn Ala Ala Gly Gln   Gly Pro Phe Ser Glu   Pro Ser Glu 
    28070                 28075                 28080             


Phe Tyr   Lys Ala Ala Asp Pro   Ile Asp Pro Pro Gly   Pro Pro Ala 
    28085                 28090                 28095             


Lys Ile   Arg Ile Ala Asp Ser   Thr Lys Ser Ser Ile   Thr Leu Gly 
    28100                 28105                 28110             


Trp Ser   Lys Pro Val Tyr Asp   Gly Gly Ser Ala Val   Thr Gly Tyr 
    28115                 28120                 28125             


Val Val   Glu Ile Arg Gln Gly   Glu Glu Glu Glu Trp   Thr Thr Val 
    28130                 28135                 28140             


Ser Thr   Lys Gly Glu Val Arg   Thr Thr Glu Tyr Val   Val Ser Asn 
    28145                 28150                 28155             


Leu Lys   Pro Gly Val Asn Tyr   Tyr Phe Arg Val Ser   Ala Val Asn 
    28160                 28165                 28170             


Cys Ala   Gly Gln Gly Glu Pro   Ile Glu Met Asn Glu   Pro Val Gln 
    28175                 28180                 28185             


Ala Lys   Asp Ile Leu Glu Ala   Pro Glu Ile Asp Leu   Asp Val Ala 
    28190                 28195                 28200             


Leu Arg   Thr Ser Val Ile Ala   Lys Ala Gly Glu Asp   Val Gln Val 
    28205                 28210                 28215             


Leu Ile   Pro Phe Lys Gly Arg   Pro Pro Pro Thr Val   Thr Trp Arg 
    28220                 28225                 28230             


Lys Asp   Glu Lys Asn Leu Gly   Ser Asp Ala Arg Tyr   Ser Ile Glu 
    28235                 28240                 28245             


Asn Thr   Asp Ser Ser Ser Leu   Leu Thr Ile Pro Gln   Val Thr Arg 
    28250                 28255                 28260             


Asn Asp   Thr Gly Lys Tyr Ile   Leu Thr Ile Glu Asn   Gly Val Gly 
    28265                 28270                 28275             


Glu Pro   Lys Ser Ser Thr Val   Ser Val Lys Val Leu   Asp Thr Pro 
    28280                 28285                 28290             


Ala Ala   Cys Gln Lys Leu Gln   Val Lys His Val Ser   Arg Gly Thr 
    28295                 28300                 28305             


Val Thr   Leu Leu Trp Asp Pro   Pro Leu Ile Asp Gly   Gly Ser Pro 
    28310                 28315                 28320             


Ile Ile   Asn Tyr Val Ile Glu   Lys Arg Asp Ala Thr   Lys Arg Thr 
    28325                 28330                 28335             


Trp Ser   Val Val Ser His Lys   Cys Ser Ser Thr Ser   Phe Lys Leu 
    28340                 28345                 28350             


Ile Asp   Leu Ser Glu Lys Thr   Pro Phe Phe Phe Arg   Val Leu Ala 
    28355                 28360                 28365             


Glu Asn   Glu Ile Gly Ile Gly   Glu Pro Cys Glu Thr   Thr Glu Pro 
    28370                 28375                 28380             


Val Lys   Ala Ala Glu Val Pro   Ala Pro Ile Arg Asp   Leu Ser Met 
    28385                 28390                 28395             


Lys Asp   Ser Thr Lys Thr Ser   Val Ile Leu Ser Trp   Thr Lys Pro 
    28400                 28405                 28410             


Asp Phe   Asp Gly Gly Ser Val   Ile Thr Glu Tyr Val   Val Glu Arg 
    28415                 28420                 28425             


Lys Gly   Lys Gly Glu Gln Thr   Trp Ser His Ala Gly   Ile Ser Lys 
    28430                 28435                 28440             


Thr Cys   Glu Ile Glu Val Ser   Gln Leu Lys Glu Gln   Ser Val Leu 
    28445                 28450                 28455             


Glu Phe   Arg Val Phe Ala Lys   Asn Glu Lys Gly Leu   Ser Asp Pro 
    28460                 28465                 28470             


Val Thr   Ile Gly Pro Ile Thr   Val Lys Glu Leu Ile   Ile Thr Pro 
    28475                 28480                 28485             


Glu Val   Asp Leu Ser Asp Ile   Pro Gly Ala Gln Val   Thr Val Arg 
    28490                 28495                 28500             


Ile Gly   His Asn Val His Leu   Glu Leu Pro Tyr Lys   Gly Lys Pro 
    28505                 28510                 28515             


Lys Pro   Ser Ile Ser Trp Leu   Lys Asp Gly Leu Pro   Leu Lys Glu 
    28520                 28525                 28530             


Ser Glu   Phe Val Arg Phe Ser   Lys Thr Glu Asn Lys   Ile Thr Leu 
    28535                 28540                 28545             


Ser Ile   Lys Asn Ala Lys Lys   Glu His Gly Gly Lys   Tyr Thr Val 
    28550                 28555                 28560             


Ile Leu   Asp Asn Ala Val Cys   Arg Ile Ala Val Pro   Ile Thr Val 
    28565                 28570                 28575             


Ile Thr   Leu Gly Pro Pro Ser   Lys Pro Lys Gly Pro   Ile Arg Phe 
    28580                 28585                 28590             


Asp Glu   Ile Lys Ala Asp Ser   Val Ile Leu Ser Trp   Asp Val Pro 
    28595                 28600                 28605             


Glu Asp   Asn Gly Gly Gly Glu   Ile Thr Cys Tyr Ser   Ile Glu Lys 
    28610                 28615                 28620             


Arg Glu   Thr Ser Gln Thr Asn   Trp Lys Met Val Cys   Ser Ser Val 
    28625                 28630                 28635             


Ala Arg   Thr Thr Phe Lys Val   Pro Asn Leu Val Lys   Asp Ala Glu 
    28640                 28645                 28650             


Tyr Gln   Phe Arg Val Arg Ala   Glu Asn Arg Tyr Gly   Val Ser Gln 
    28655                 28660                 28665             


Pro Leu   Val Ser Ser Ile Ile   Val Ala Lys His Gln   Phe Arg Ile 
    28670                 28675                 28680             


Pro Gly   Pro Pro Gly Lys Pro   Val Ile Tyr Asn Val   Thr Ser Asp 
    28685                 28690                 28695             


Gly Met   Ser Leu Thr Trp Asp   Ala Pro Val Tyr Asp   Gly Gly Ser 
    28700                 28705                 28710             


Glu Val   Thr Gly Phe His Val   Glu Lys Lys Glu Arg   Asn Ser Ile 
    28715                 28720                 28725             


Leu Trp   Gln Lys Val Asn Thr   Ser Pro Ile Ser Gly   Arg Glu Tyr 
    28730                 28735                 28740             


Arg Ala   Thr Gly Leu Val Glu   Gly Leu Asp Tyr Gln   Phe Arg Val 
    28745                 28750                 28755             


Tyr Ala   Glu Asn Ser Ala Gly   Leu Ser Ser Pro Ser   Asp Pro Ser 
    28760                 28765                 28770             


Lys Phe   Thr Leu Ala Val Ser   Pro Val Asp Pro Pro   Gly Thr Pro 
    28775                 28780                 28785             


Asp Tyr   Ile Asp Val Thr Arg   Glu Thr Ile Thr Leu   Lys Trp Asn 
    28790                 28795                 28800             


Pro Pro   Leu Arg Asp Gly Gly   Ser Lys Ile Val Gly   Tyr Ser Ile 
    28805                 28810                 28815             


Glu Lys   Arg Gln Gly Asn Glu   Arg Trp Val Arg Cys   Asn Phe Thr 
    28820                 28825                 28830             


Asp Val   Ser Glu Cys Gln Tyr   Thr Val Thr Gly Leu   Ser Pro Gly 
    28835                 28840                 28845             


Asp Arg   Tyr Glu Phe Arg Ile   Ile Ala Arg Asn Ala   Val Gly Thr 
    28850                 28855                 28860             


Ile Ser   Pro Pro Ser Gln Ser   Ser Gly Ile Ile Met   Thr Arg Asp 
    28865                 28870                 28875             


Glu Asn   Val Pro Pro Ile Val   Glu Phe Gly Pro Glu   Tyr Phe Asp 
    28880                 28885                 28890             


Gly Leu   Ile Ile Lys Ser Gly   Glu Ser Leu Arg Ile   Lys Ala Leu 
    28895                 28900                 28905             


Val Gln   Gly Arg Pro Val Pro   Arg Val Thr Trp Phe   Lys Asp Gly 
    28910                 28915                 28920             


Val Glu   Ile Glu Lys Arg Met   Asn Met Glu Ile Thr   Asp Val Leu 
    28925                 28930                 28935             


Gly Ser   Thr Ser Leu Phe Val   Arg Asp Ala Thr Arg   Asp His Arg 
    28940                 28945                 28950             


Gly Val   Tyr Thr Val Glu Ala   Lys Asn Ala Ser Gly   Ser Ala Lys 
    28955                 28960                 28965             


Ala Glu   Ile Lys Val Lys Val   Gln Asp Thr Pro Gly   Lys Val Val 
    28970                 28975                 28980             


Gly Pro   Ile Arg Phe Thr Asn   Ile Thr Gly Glu Lys   Met Thr Leu 
    28985                 28990                 28995             


Trp Trp   Asp Ala Pro Leu Asn   Asp Gly Cys Ala Pro   Ile Thr His 
    29000                 29005                 29010             


Tyr Ile   Ile Glu Lys Arg Glu   Thr Ser Arg Leu Ala   Trp Ala Leu 
    29015                 29020                 29025             


Ile Glu   Asp Lys Cys Glu Ala   Gln Ser Tyr Thr Ala   Ile Lys Leu 
    29030                 29035                 29040             


Ile Asn   Gly Asn Glu Tyr Gln   Phe Arg Val Ser Ala   Val Asn Lys 
    29045                 29050                 29055             


Phe Gly   Val Gly Arg Pro Leu   Asp Ser Asp Pro Val   Val Ala Gln 
    29060                 29065                 29070             


Ile Gln   Tyr Thr Val Pro Asp   Ala Pro Gly Ile Pro   Glu Pro Ser 
    29075                 29080                 29085             


Asn Ile   Thr Gly Asn Ser Ile   Thr Leu Thr Trp Ala   Arg Pro Glu 
    29090                 29095                 29100             


Ser Asp   Gly Gly Ser Glu Ile   Gln Gln Tyr Ile Leu   Glu Arg Arg 
    29105                 29110                 29115             


Glu Lys   Lys Ser Thr Arg Trp   Val Lys Val Ile Ser   Lys Arg Pro 
    29120                 29125                 29130             


Ile Ser   Glu Thr Arg Phe Lys   Val Thr Gly Leu Thr   Glu Gly Asn 
    29135                 29140                 29145             


Glu Tyr   Glu Phe His Val Met   Ala Glu Asn Ala Ala   Gly Val Gly 
    29150                 29155                 29160             


Pro Ala   Ser Gly Ile Ser Arg   Leu Ile Lys Cys Arg   Glu Pro Val 
    29165                 29170                 29175             


Asn Pro   Pro Gly Pro Pro Thr   Val Val Lys Val Thr   Asp Thr Ser 
    29180                 29185                 29190             


Lys Thr   Thr Val Ser Leu Glu   Trp Ser Lys Pro Val   Phe Asp Gly 
    29195                 29200                 29205             


Gly Met   Glu Ile Ile Gly Tyr   Ile Ile Glu Met Cys   Lys Ala Asp 
    29210                 29215                 29220             


Leu Gly   Asp Trp His Lys Val   Asn Ala Glu Ala Cys   Val Lys Thr 
    29225                 29230                 29235             


Arg Tyr   Thr Val Thr Asp Leu   Gln Ala Gly Glu Glu   Tyr Lys Phe 
    29240                 29245                 29250             


Arg Val   Ser Ala Ile Asn Gly   Ala Gly Lys Gly Asp   Ser Cys Glu 
    29255                 29260                 29265             


Val Thr   Gly Thr Ile Lys Ala   Val Asp Arg Leu Thr   Ala Pro Glu 
    29270                 29275                 29280             


Leu Asp   Ile Asp Ala Asn Phe   Lys Gln Thr His Val   Val Arg Ala 
    29285                 29290                 29295             


Gly Ala   Ser Ile Arg Leu Phe   Ile Ala Tyr Gln Gly   Arg Pro Thr 
    29300                 29305                 29310             


Pro Thr   Ala Val Trp Ser Lys   Pro Asp Ser Asn Leu   Ser Leu Arg 
    29315                 29320                 29325             


Ala Asp   Ile His Thr Thr Asp   Ser Phe Ser Thr Leu   Thr Val Glu 
    29330                 29335                 29340             


Asn Cys   Asn Arg Asn Asp Ala   Gly Lys Tyr Thr Leu   Thr Val Glu 
    29345                 29350                 29355             


Asn Asn   Ser Gly Ser Lys Ser   Ile Thr Phe Thr Val   Lys Val Leu 
    29360                 29365                 29370             


Asp Thr   Pro Gly Pro Pro Gly   Pro Ile Thr Phe Lys   Asp Val Thr 
    29375                 29380                 29385             


Arg Gly   Ser Ala Thr Leu Met   Trp Asp Ala Pro Leu   Leu Asp Gly 
    29390                 29395                 29400             


Gly Ala   Arg Ile His His Tyr   Val Val Glu Lys Arg   Glu Ala Ser 
    29405                 29410                 29415             


Arg Arg   Ser Trp Gln Val Ile   Ser Glu Lys Cys Thr   Arg Gln Ile 
    29420                 29425                 29430             


Phe Lys   Val Asn Asp Leu Ala   Glu Gly Val Pro Tyr   Tyr Phe Arg 
    29435                 29440                 29445             


Val Ser   Ala Val Asn Glu Tyr   Gly Val Gly Glu Pro   Tyr Glu Met 
    29450                 29455                 29460             


Pro Glu   Pro Ile Val Ala Thr   Glu Gln Pro Ala Pro   Pro Arg Arg 
    29465                 29470                 29475             


Leu Asp   Val Val Asp Thr Ser   Lys Ser Ser Ala Val   Leu Ala Trp 
    29480                 29485                 29490             


Leu Lys   Pro Asp His Asp Gly   Gly Ser Arg Ile Thr   Gly Tyr Leu 
    29495                 29500                 29505             


Leu Glu   Met Arg Gln Lys Gly   Ser Asp Phe Trp Val   Glu Ala Gly 
    29510                 29515                 29520             


His Thr   Lys Gln Leu Thr Phe   Thr Val Glu Arg Leu   Val Glu Lys 
    29525                 29530                 29535             


Thr Glu   Tyr Glu Phe Arg Val   Lys Ala Lys Asn Asp   Ala Gly Tyr 
    29540                 29545                 29550             


Ser Glu   Pro Arg Glu Ala Phe   Ser Ser Val Ile Ile   Lys Glu Pro 
    29555                 29560                 29565             


Gln Ile   Glu Pro Thr Ala Asp   Leu Thr Gly Ile Thr   Asn Gln Leu 
    29570                 29575                 29580             


Ile Thr   Cys Lys Ala Gly Ser   Pro Phe Thr Ile Asp   Val Pro Ile 
    29585                 29590                 29595             


Ser Gly   Arg Pro Ala Pro Lys   Val Thr Trp Lys Leu   Glu Glu Met 
    29600                 29605                 29610             


Arg Leu   Lys Glu Thr Asp Arg   Val Ser Ile Thr Thr   Thr Lys Asp 
    29615                 29620                 29625             


Arg Thr   Thr Leu Thr Val Lys   Asp Ser Met Arg Gly   Asp Ser Gly 
    29630                 29635                 29640             


Arg Tyr   Phe Leu Thr Leu Glu   Asn Thr Ala Gly Val   Lys Thr Phe 
    29645                 29650                 29655             


Ser Val   Thr Val Val Val Ile   Gly Arg Pro Gly Pro   Val Thr Gly 
    29660                 29665                 29670             


Pro Ile   Glu Val Ser Ser Val   Ser Ala Glu Ser Cys   Val Leu Ser 
    29675                 29680                 29685             


Trp Gly   Glu Pro Lys Asp Gly   Gly Gly Thr Glu Ile   Thr Asn Tyr 
    29690                 29695                 29700             


Ile Val   Glu Lys Arg Glu Ser   Gly Thr Thr Ala Trp   Gln Leu Val 
    29705                 29710                 29715             


Asn Ser   Ser Val Lys Arg Thr   Gln Ile Lys Val Thr   His Leu Thr 
    29720                 29725                 29730             


Lys Tyr   Met Glu Tyr Ser Phe   Arg Val Ser Ser Glu   Asn Arg Phe 
    29735                 29740                 29745             


Gly Val   Ser Lys Pro Leu Glu   Ser Ala Pro Ile Ile   Ala Glu His 
    29750                 29755                 29760             


Pro Phe   Val Pro Pro Ser Ala   Pro Thr Arg Pro Glu   Val Tyr His 
    29765                 29770                 29775             


Val Ser   Ala Asn Ala Met Ser   Ile Arg Trp Glu Glu   Pro Tyr His 
    29780                 29785                 29790             


Asp Gly   Gly Ser Lys Ile Ile   Gly Tyr Trp Val Glu   Lys Lys Glu 
    29795                 29800                 29805             


Arg Asn   Thr Ile Leu Trp Val   Lys Glu Asn Lys Val   Pro Cys Leu 
    29810                 29815                 29820             


Glu Cys   Asn Tyr Lys Val Thr   Gly Leu Val Glu Gly   Leu Glu Tyr 
    29825                 29830                 29835             


Gln Phe   Arg Thr Tyr Ala Leu   Asn Ala Ala Gly Val   Ser Lys Ala 
    29840                 29845                 29850             


Ser Glu   Ala Ser Arg Pro Ile   Met Ala Gln Asn Pro   Val Asp Ala 
    29855                 29860                 29865             


Pro Gly   Arg Pro Glu Val Thr   Asp Val Thr Arg Ser   Thr Val Ser 
    29870                 29875                 29880             


Leu Ile   Trp Ser Ala Pro Ala   Tyr Asp Gly Gly Ser   Lys Val Val 
    29885                 29890                 29895             


Gly Tyr   Ile Ile Glu Arg Lys   Pro Val Ser Glu Val   Gly Asp Gly 
    29900                 29905                 29910             


Arg Trp   Leu Lys Cys Asn Tyr   Thr Ile Val Ser Asp   Asn Phe Phe 
    29915                 29920                 29925             


Thr Val   Thr Ala Leu Ser Glu   Gly Asp Thr Tyr Glu   Phe Arg Val 
    29930                 29935                 29940             


Leu Ala   Lys Asn Ala Ala Gly   Val Ile Ser Lys Gly   Ser Glu Ser 
    29945                 29950                 29955             


Thr Gly   Pro Val Thr Cys Arg   Asp Glu Tyr Ala Pro   Pro Lys Ala 
    29960                 29965                 29970             


Glu Leu   Asp Ala Arg Leu His   Gly Asp Leu Val Thr   Ile Arg Ala 
    29975                 29980                 29985             


Gly Ser   Asp Leu Val Leu Asp   Ala Ala Val Gly Gly   Lys Pro Glu 
    29990                 29995                 30000             


Pro Lys   Ile Ile Trp Thr Lys   Gly Asp Lys Glu Leu   Asp Leu Cys 
    30005                 30010                 30015             


Glu Lys   Val Ser Leu Gln Tyr   Thr Gly Lys Arg Ala   Thr Ala Val 
    30020                 30025                 30030             


Ile Lys   Phe Cys Asp Arg Ser   Asp Ser Gly Lys Tyr   Thr Leu Thr 
    30035                 30040                 30045             


Val Lys   Asn Ala Ser Gly Thr   Lys Ala Val Ser Val   Met Val Lys 
    30050                 30055                 30060             


Val Leu   Asp Ser Pro Gly Pro   Cys Gly Lys Leu Thr   Val Ser Arg 
    30065                 30070                 30075             


Val Thr   Gln Glu Lys Cys Thr   Leu Ala Trp Ser Leu   Pro Gln Glu 
    30080                 30085                 30090             


Asp Gly   Gly Ala Glu Ile Thr   His Tyr Ile Val Glu   Arg Arg Glu 
    30095                 30100                 30105             


Thr Ser   Arg Leu Asn Trp Val   Ile Val Glu Gly Glu   Cys Pro Thr 
    30110                 30115                 30120             


Leu Ser   Tyr Val Val Thr Arg   Leu Ile Lys Asn Asn   Glu Tyr Ile 
    30125                 30130                 30135             


Phe Arg   Val Arg Ala Val Asn   Lys Tyr Gly Pro Gly   Val Pro Val 
    30140                 30145                 30150             


Glu Ser   Glu Pro Ile Val Ala   Arg Asn Ser Phe Thr   Ile Pro Ser 
    30155                 30160                 30165             


Pro Pro   Gly Ile Pro Glu Glu   Val Gly Thr Gly Lys   Glu His Ile 
    30170                 30175                 30180             


Ile Ile   Gln Trp Thr Lys Pro   Glu Ser Asp Gly Gly   Asn Glu Ile 
    30185                 30190                 30195             


Ser Asn   Tyr Leu Val Asp Lys   Arg Glu Lys Lys Ser   Leu Arg Trp 
    30200                 30205                 30210             


Thr Arg   Val Asn Lys Asp Tyr   Val Val Tyr Asp Thr   Arg Leu Lys 
    30215                 30220                 30225             


Val Thr   Ser Leu Met Glu Gly   Cys Asp Tyr Gln Phe   Arg Val Thr 
    30230                 30235                 30240             


Ala Val   Asn Ala Ala Gly Asn   Ser Glu Pro Ser Glu   Ala Ser Asn 
    30245                 30250                 30255             


Phe Ile   Ser Cys Arg Glu Pro   Ser Tyr Thr Pro Gly   Pro Pro Ser 
    30260                 30265                 30270             


Ala Pro   Arg Val Val Asp Thr   Thr Lys His Ser Ile   Ser Leu Ala 
    30275                 30280                 30285             


Trp Thr   Lys Pro Met Tyr Asp   Gly Gly Thr Asp Ile   Val Gly Tyr 
    30290                 30295                 30300             


Val Leu   Glu Met Gln Glu Lys   Asp Thr Asp Gln Trp   Tyr Arg Val 
    30305                 30310                 30315             


His Thr   Asn Ala Thr Ile Arg   Asn Thr Glu Phe Thr   Val Pro Asp 
    30320                 30325                 30330             


Leu Lys   Met Gly Gln Lys Tyr   Ser Phe Arg Val Ala   Ala Val Asn 
    30335                 30340                 30345             


Val Lys   Gly Met Ser Glu Tyr   Ser Glu Ser Ile Ala   Glu Ile Glu 
    30350                 30355                 30360             


Pro Val   Glu Arg Ile Glu Ile   Pro Asp Leu Glu Leu   Ala Asp Asp 
    30365                 30370                 30375             


Leu Lys   Lys Thr Val Thr Ile   Arg Ala Gly Ala Ser   Leu Arg Leu 
    30380                 30385                 30390             


Met Val   Ser Val Ser Gly Arg   Pro Pro Pro Val Ile   Thr Trp Ser 
    30395                 30400                 30405             


Lys Gln   Gly Ile Asp Leu Ala   Ser Arg Ala Ile Ile   Asp Thr Thr 
    30410                 30415                 30420             


Glu Ser   Tyr Ser Leu Leu Ile   Val Asp Lys Val Asn   Arg Tyr Asp 
    30425                 30430                 30435             


Ala Gly   Lys Tyr Thr Ile Glu   Ala Glu Asn Gln Ser   Gly Lys Lys 
    30440                 30445                 30450             


Ser Ala   Thr Val Leu Val Lys   Val Tyr Asp Thr Pro   Gly Pro Cys 
    30455                 30460                 30465             


Pro Ser   Val Lys Val Lys Glu   Val Ser Arg Asp Ser   Val Thr Ile 
    30470                 30475                 30480             


Thr Trp   Glu Ile Pro Thr Ile   Asp Gly Gly Ala Pro   Val Asn Asn 
    30485                 30490                 30495             


Tyr Ile   Val Glu Lys Arg Glu   Ala Ala Met Arg Ala   Phe Lys Thr 
    30500                 30505                 30510             


Val Thr   Thr Lys Cys Ser Lys   Thr Leu Tyr Arg Ile   Ser Gly Leu 
    30515                 30520                 30525             


Val Glu   Gly Thr Met Tyr Tyr   Phe Arg Val Leu Pro   Glu Asn Ile 
    30530                 30535                 30540             


Tyr Gly   Ile Gly Glu Pro Cys   Glu Thr Ser Asp Ala   Val Leu Val 
    30545                 30550                 30555             


Ser Glu   Val Pro Leu Val Pro   Ala Lys Leu Glu Val   Val Asp Val 
    30560                 30565                 30570             


Thr Lys   Ser Thr Val Thr Leu   Ala Trp Glu Lys Pro   Leu Tyr Asp 
    30575                 30580                 30585             


Gly Gly   Ser Arg Leu Thr Gly   Tyr Val Leu Glu Ala   Cys Lys Ala 
    30590                 30595                 30600             


Gly Thr   Glu Arg Trp Met Lys   Val Val Thr Leu Lys   Pro Thr Val 
    30605                 30610                 30615             


Leu Glu   His Thr Val Thr Ser   Leu Asn Glu Gly Glu   Gln Tyr Leu 
    30620                 30625                 30630             


Phe Arg   Ile Arg Ala Gln Asn   Glu Lys Gly Val Ser   Glu Pro Arg 
    30635                 30640                 30645             


Glu Thr   Val Thr Ala Val Thr   Val Gln Asp Leu Arg   Val Leu Pro 
    30650                 30655                 30660             


Thr Ile   Asp Leu Ser Thr Met   Pro Gln Lys Thr Ile   His Val Pro 
    30665                 30670                 30675             


Ala Gly   Arg Pro Val Glu Leu   Val Ile Pro Ile Ala   Gly Arg Pro 
    30680                 30685                 30690             


Pro Pro   Ala Ala Ser Trp Phe   Phe Ala Gly Ser Lys   Leu Arg Glu 
    30695                 30700                 30705             


Ser Glu   Arg Val Thr Val Glu   Thr His Thr Lys Val   Ala Lys Leu 
    30710                 30715                 30720             


Thr Ile   Arg Glu Thr Thr Ile   Arg Asp Thr Gly Glu   Tyr Thr Leu 
    30725                 30730                 30735             


Glu Leu   Lys Asn Val Thr Gly   Thr Thr Ser Glu Thr   Ile Lys Val 
    30740                 30745                 30750             


Ile Ile   Leu Asp Lys Pro Gly   Pro Pro Thr Gly Pro   Ile Lys Ile 
    30755                 30760                 30765             


Asp Glu   Ile Asp Ala Thr Ser   Ile Thr Ile Ser Trp   Glu Pro Pro 
    30770                 30775                 30780             


Glu Leu   Asp Gly Gly Ala Pro   Leu Ser Gly Tyr Val   Val Glu Gln 
    30785                 30790                 30795             


Arg Asp   Ala His Arg Pro Gly   Trp Leu Pro Val Ser   Glu Ser Val 
    30800                 30805                 30810             


Thr Arg   Ser Thr Phe Lys Phe   Thr Arg Leu Thr Glu   Gly Asn Glu 
    30815                 30820                 30825             


Tyr Val   Phe Arg Val Ala Ala   Thr Asn Arg Phe Gly   Ile Gly Ser 
    30830                 30835                 30840             


Tyr Leu   Gln Ser Glu Val Ile   Glu Cys Arg Ser Ser   Ile Arg Ile 
    30845                 30850                 30855             


Pro Gly   Pro Pro Glu Thr Leu   Gln Ile Phe Asp Val   Ser Arg Asp 
    30860                 30865                 30870             


Gly Met   Thr Leu Thr Trp Tyr   Pro Pro Glu Asp Asp   Gly Gly Ser 
    30875                 30880                 30885             


Gln Val   Thr Gly Tyr Ile Val   Glu Arg Lys Glu Val   Arg Ala Asp 
    30890                 30895                 30900             


Arg Trp   Val Arg Val Asn Lys   Val Pro Val Thr Met   Thr Arg Tyr 
    30905                 30910                 30915             


Arg Ser   Thr Gly Leu Thr Glu   Gly Leu Glu Tyr Glu   His Arg Val 
    30920                 30925                 30930             


Thr Ala   Ile Asn Ala Arg Gly   Ser Gly Lys Pro Ser   Arg Pro Ser 
    30935                 30940                 30945             


Lys Pro   Ile Val Ala Met Asp   Pro Ile Ala Pro Pro   Gly Lys Pro 
    30950                 30955                 30960             


Gln Asn   Pro Arg Val Thr Asp   Thr Thr Arg Thr Ser   Val Ser Leu 
    30965                 30970                 30975             


Ala Trp   Ser Val Pro Glu Asp   Glu Gly Gly Ser Lys   Val Thr Gly 
    30980                 30985                 30990             


Tyr Leu   Ile Glu Met Gln Lys   Val Asp Gln His Glu   Trp Thr Lys 
    30995                 31000                 31005             


Cys Asn   Thr Thr Pro Thr Lys   Ile Arg Glu Tyr Thr   Leu Thr His 
    31010                 31015                 31020             


Leu Pro   Gln Gly Ala Glu Tyr   Arg Phe Arg Val Leu   Ala Cys Asn 
    31025                 31030                 31035             


Ala Gly   Gly Pro Gly Glu Pro   Ala Glu Val Pro Gly   Thr Val Lys 
    31040                 31045                 31050             


Val Thr   Glu Met Leu Glu Tyr   Pro Asp Tyr Glu Leu   Asp Glu Arg 
    31055                 31060                 31065             


Tyr Gln   Glu Gly Ile Phe Val   Arg Gln Gly Gly Val   Ile Arg Leu 
    31070                 31075                 31080             


Thr Ile   Pro Ile Lys Gly Lys   Pro Phe Pro Ile Cys   Lys Trp Thr 
    31085                 31090                 31095             


Lys Glu   Gly Gln Asp Ile Ser   Lys Arg Ala Met Ile   Ala Thr Ser 
    31100                 31105                 31110             


Glu Thr   His Thr Glu Leu Val   Ile Lys Glu Ala Asp   Arg Gly Asp 
    31115                 31120                 31125             


Ser Gly   Thr Tyr Asp Leu Val   Leu Glu Asn Lys Cys   Gly Lys Lys 
    31130                 31135                 31140             


Ala Val   Tyr Ile Lys Val Arg   Val Ile Gly Ser Pro   Asn Ser Pro 
    31145                 31150                 31155             


Glu Gly   Pro Leu Glu Tyr Asp   Asp Ile Gln Val Arg   Ser Val Arg 
    31160                 31165                 31170             


Val Ser   Trp Arg Pro Pro Ala   Asp Asp Gly Gly Ala   Asp Ile Leu 
    31175                 31180                 31185             


Gly Tyr   Ile Leu Glu Arg Arg   Glu Val Pro Lys Ala   Ala Trp Tyr 
    31190                 31195                 31200             


Thr Ile   Asp Ser Arg Val Arg   Gly Thr Ser Leu Val   Val Lys Gly 
    31205                 31210                 31215             


Leu Lys   Glu Asn Val Glu Tyr   His Phe Arg Val Ser   Ala Glu Asn 
    31220                 31225                 31230             


Gln Phe   Gly Ile Ser Lys Pro   Leu Lys Ser Glu Glu   Pro Val Thr 
    31235                 31240                 31245             


Pro Lys   Thr Pro Leu Asn Pro   Pro Glu Pro Pro Ser   Asn Pro Pro 
    31250                 31255                 31260             


Glu Val   Leu Asp Val Thr Lys   Ser Ser Val Ser Leu   Ser Trp Ser 
    31265                 31270                 31275             


Arg Pro   Lys Asp Asp Gly Gly   Ser Arg Val Thr Gly   Tyr Tyr Ile 
    31280                 31285                 31290             


Glu Arg   Lys Glu Thr Ser Thr   Asp Lys Trp Val Arg   His Asn Lys 
    31295                 31300                 31305             


Thr Gln   Ile Thr Thr Thr Met   Tyr Thr Val Thr Gly   Leu Val Pro 
    31310                 31315                 31320             


Asp Ala   Glu Tyr Gln Phe Arg   Ile Ile Ala Gln Asn   Asp Val Gly 
    31325                 31330                 31335             


Leu Ser   Glu Thr Ser Pro Ala   Ser Glu Pro Val Val   Cys Lys Asp 
    31340                 31345                 31350             


Pro Phe   Asp Lys Pro Ser Gln   Pro Gly Glu Leu Glu   Ile Leu Ser 
    31355                 31360                 31365             


Ile Ser   Lys Asp Ser Val Thr   Leu Gln Trp Glu Lys   Pro Glu Cys 
    31370                 31375                 31380             


Asp Gly   Gly Lys Glu Ile Leu   Gly Tyr Trp Val Glu   Tyr Arg Gln 
    31385                 31390                 31395             


Ser Gly   Asp Ser Ala Trp Lys   Lys Ser Asn Lys Glu   Arg Ile Lys 
    31400                 31405                 31410             


Asp Lys   Gln Phe Thr Ile Gly   Gly Leu Leu Glu Ala   Thr Glu Tyr 
    31415                 31420                 31425             


Glu Phe   Arg Val Phe Ala Glu   Asn Glu Thr Gly Leu   Ser Arg Pro 
    31430                 31435                 31440             


Arg Arg   Thr Ala Met Ser Ile   Lys Thr Lys Leu Thr   Ser Gly Glu 
    31445                 31450                 31455             


Ala Pro   Gly Ile Arg Lys Glu   Met Lys Asp Val Thr   Thr Lys Leu 
    31460                 31465                 31470             


Gly Glu   Ala Ala Gln Leu Ser   Cys Gln Ile Val Gly   Arg Pro Leu 
    31475                 31480                 31485             


Pro Asp   Ile Lys Trp Tyr Arg   Phe Gly Lys Glu Leu   Ile Gln Ser 
    31490                 31495                 31500             


Arg Lys   Tyr Lys Met Ser Ser   Asp Gly Arg Thr His   Thr Leu Thr 
    31505                 31510                 31515             


Val Met   Thr Glu Glu Gln Glu   Asp Glu Gly Val Tyr   Thr Cys Ile 
    31520                 31525                 31530             


Ala Thr   Asn Glu Val Gly Glu   Val Glu Thr Ser Ser   Lys Leu Leu 
    31535                 31540                 31545             


Leu Gln   Ala Thr Pro Gln Phe   His Pro Gly Tyr Pro   Leu Lys Glu 
    31550                 31555                 31560             


Lys Tyr   Tyr Gly Ala Val Gly   Ser Thr Leu Arg Leu   His Val Met 
    31565                 31570                 31575             


Tyr Ile   Gly Arg Pro Val Pro   Ala Met Thr Trp Phe   His Gly Gln 
    31580                 31585                 31590             


Lys Leu   Leu Gln Asn Ser Glu   Asn Ile Thr Ile Glu   Asn Thr Glu 
    31595                 31600                 31605             


His Tyr   Thr His Leu Val Met   Lys Asn Val Gln Arg   Lys Thr His 
    31610                 31615                 31620             


Ala Gly   Lys Tyr Lys Val Gln   Leu Ser Asn Val Phe   Gly Thr Val 
    31625                 31630                 31635             


Asp Ala   Ile Leu Asp Val Glu   Ile Gln Asp Lys Pro   Asp Lys Pro 
    31640                 31645                 31650             


Thr Gly   Pro Ile Val Ile Glu   Ala Leu Leu Lys Asn   Ser Ala Val 
    31655                 31660                 31665             


Ile Ser   Trp Lys Pro Pro Ala   Asp Asp Gly Gly Ser   Trp Ile Thr 
    31670                 31675                 31680             


Asn Tyr   Val Val Glu Lys Cys   Glu Ala Lys Glu Gly   Ala Glu Trp 
    31685                 31690                 31695             


Gln Leu   Val Ser Ser Ala Ile   Ser Val Thr Thr Cys   Arg Ile Val 
    31700                 31705                 31710             


Asn Leu   Thr Glu Asn Ala Gly   Tyr Tyr Phe Arg Val   Ser Ala Gln 
    31715                 31720                 31725             


Asn Thr   Phe Gly Ile Ser Asp   Pro Leu Glu Val Ser   Ser Val Val 
    31730                 31735                 31740             


Ile Ile   Lys Ser Pro Phe Glu   Lys Pro Gly Ala Pro   Gly Lys Pro 
    31745                 31750                 31755             


Thr Ile   Thr Ala Val Thr Lys   Asp Ser Cys Val Val   Ala Trp Lys 
    31760                 31765                 31770             


Pro Pro   Ala Ser Asp Gly Gly   Ala Lys Ile Arg Asn   Tyr Tyr Leu 
    31775                 31780                 31785             


Glu Lys   Arg Glu Lys Lys Gln   Asn Lys Trp Ile Ser   Val Thr Thr 
    31790                 31795                 31800             


Glu Glu   Ile Arg Glu Thr Val   Phe Ser Val Lys Asn   Leu Ile Glu 
    31805                 31810                 31815             


Gly Leu   Glu Tyr Glu Phe Arg   Val Lys Cys Glu Asn   Leu Gly Gly 
    31820                 31825                 31830             


Glu Ser   Glu Trp Ser Glu Ile   Ser Glu Pro Ile Thr   Pro Lys Ser 
    31835                 31840                 31845             


Asp Val   Pro Ile Gln Ala Pro   His Phe Lys Glu Glu   Leu Arg Asn 
    31850                 31855                 31860             


Leu Asn   Val Arg Tyr Gln Ser   Asn Ala Thr Leu Val   Cys Lys Val 
    31865                 31870                 31875             


Thr Gly   His Pro Lys Pro Ile   Val Lys Trp Tyr Arg   Gln Gly Lys 
    31880                 31885                 31890             


Glu Ile   Ile Ala Asp Gly Leu   Lys Tyr Arg Ile Gln   Glu Phe Lys 
    31895                 31900                 31905             


Gly Gly   Tyr His Gln Leu Ile   Ile Ala Ser Val Thr   Asp Asp Asp 
    31910                 31915                 31920             


Ala Thr   Val Tyr Gln Val Arg   Ala Thr Asn Gln Gly   Gly Ser Val 
    31925                 31930                 31935             


Ser Gly   Thr Ala Ser Leu Glu   Val Glu Val Pro Ala   Lys Ile His 
    31940                 31945                 31950             


Leu Pro   Lys Thr Leu Glu Gly   Met Gly Ala Val His   Ala Leu Arg 
    31955                 31960                 31965             


Gly Glu   Val Val Ser Ile Lys   Ile Pro Phe Ser Gly   Lys Pro Asp 
    31970                 31975                 31980             


Pro Val   Ile Thr Trp Gln Lys   Gly Gln Asp Leu Ile   Asp Asn Asn 
    31985                 31990                 31995             


Gly His   Tyr Gln Val Ile Val   Thr Arg Ser Phe Thr   Ser Leu Val 
    32000                 32005                 32010             


Phe Pro   Asn Gly Val Glu Arg   Lys Asp Ala Gly Phe   Tyr Val Val 
    32015                 32020                 32025             


Cys Ala   Lys Asn Arg Phe Gly   Ile Asp Gln Lys Thr   Val Glu Leu 
    32030                 32035                 32040             


Asp Val   Ala Asp Val Pro Asp   Pro Pro Arg Gly Val   Lys Val Ser 
    32045                 32050                 32055             


Asp Val   Ser Arg Asp Ser Val   Asn Leu Thr Trp Thr   Glu Pro Ala 
    32060                 32065                 32070             


Ser Asp   Gly Gly Ser Lys Ile   Thr Asn Tyr Ile Val   Glu Lys Cys 
    32075                 32080                 32085             


Ala Thr   Thr Ala Glu Arg Trp   Leu Arg Val Gly Gln   Ala Arg Glu 
    32090                 32095                 32100             


Thr Arg   Tyr Thr Val Ile Asn   Leu Phe Gly Lys Thr   Ser Tyr Gln 
    32105                 32110                 32115             


Phe Arg   Val Ile Ala Glu Asn   Lys Phe Gly Leu Ser   Lys Pro Ser 
    32120                 32125                 32130             


Glu Pro   Ser Glu Pro Thr Ile   Thr Lys Glu Asp Lys   Thr Arg Ala 
    32135                 32140                 32145             


Met Asn   Tyr Asp Glu Glu Val   Asp Glu Thr Arg Glu   Val Ser Met 
    32150                 32155                 32160             


Thr Lys   Ala Ser His Ser Ser   Thr Lys Glu Leu Tyr   Glu Lys Tyr 
    32165                 32170                 32175             


Met Ile   Ala Glu Asp Leu Gly   Arg Gly Glu Phe Gly   Ile Val His 
    32180                 32185                 32190             


Arg Cys   Val Glu Thr Ser Ser   Lys Lys Thr Tyr Met   Ala Lys Phe 
    32195                 32200                 32205             


Val Lys   Val Lys Gly Thr Asp   Gln Val Leu Val Lys   Lys Glu Ile 
    32210                 32215                 32220             


Ser Ile   Leu Asn Ile Ala Arg   His Arg Asn Ile Leu   His Leu His 
    32225                 32230                 32235             


Glu Ser   Phe Glu Ser Met Glu   Glu Leu Val Met Ile   Phe Glu Phe 
    32240                 32245                 32250             


Ile Ser   Gly Leu Asp Ile Phe   Glu Arg Ile Asn Thr   Ser Ala Phe 
    32255                 32260                 32265             


Glu Leu   Asn Glu Arg Glu Ile   Val Ser Tyr Val His   Gln Val Cys 
    32270                 32275                 32280             


Glu Ala   Leu Gln Phe Leu His   Ser His Asn Ile Gly   His Phe Asp 
    32285                 32290                 32295             


Ile Arg   Pro Glu Asn Ile Ile   Tyr Gln Thr Arg Arg   Ser Ser Thr 
    32300                 32305                 32310             


Ile Lys   Ile Ile Glu Phe Gly   Gln Ala Arg Gln Leu   Lys Pro Gly 
    32315                 32320                 32325             


Asp Asn   Phe Arg Leu Leu Phe   Thr Ala Pro Glu Tyr   Tyr Ala Pro 
    32330                 32335                 32340             


Glu Val   His Gln His Asp Val   Val Ser Thr Ala Thr   Asp Met Trp 
    32345                 32350                 32355             


Ser Leu   Gly Thr Leu Val Tyr   Val Leu Leu Ser Gly   Ile Asn Pro 
    32360                 32365                 32370             


Phe Leu   Ala Glu Thr Asn Gln   Gln Ile Ile Glu Asn   Ile Met Asn 
    32375                 32380                 32385             


Ala Glu   Tyr Thr Phe Asp Glu   Glu Ala Phe Lys Glu   Ile Ser Ile 
    32390                 32395                 32400             


Glu Ala   Met Asp Phe Val Asp   Arg Leu Leu Val Lys   Glu Arg Lys 
    32405                 32410                 32415             


Ser Arg   Met Thr Ala Ser Glu   Ala Leu Gln His Pro   Trp Leu Lys 
    32420                 32425                 32430             


Gln Lys   Ile Glu Arg Val Ser   Thr Lys Val Ile Arg   Thr Leu Lys 
    32435                 32440                 32445             


His Arg   Arg Tyr Tyr His Thr   Leu Ile Lys Lys Asp   Leu Asn Met 
    32450                 32455                 32460             


Val Val   Ser Ala Ala Arg Ile   Ser Cys Gly Gly Ala   Ile Arg Ser 
    32465                 32470                 32475             


Gln Lys   Gly Val Ser Val Ala   Lys Val Lys Val Ala   Ser Ile Glu 
    32480                 32485                 32490             


Ile Gly   Pro Val Ser Gly Gln   Ile Met His Ala Val   Gly Glu Glu 
    32495                 32500                 32505             


Gly Gly   His Val Lys Tyr Val   Cys Lys Ile Glu Asn   Tyr Asp Gln 
    32510                 32515                 32520             


Ser Thr   Gln Val Thr Trp Tyr   Phe Gly Val Arg Gln   Leu Glu Asn 
    32525                 32530                 32535             


Ser Glu   Lys Tyr Glu Ile Thr   Tyr Glu Asp Gly Val   Ala Ile Leu 
    32540                 32545                 32550             


Tyr Val   Lys Asp Ile Thr Lys   Leu Asp Asp Gly Thr   Tyr Arg Cys 
    32555                 32560                 32565             


Lys Val   Val Asn Asp Tyr Gly   Glu Asp Ser Ser Tyr   Ala Glu Leu 
    32570                 32575                 32580             


Phe Val   Lys Gly Val Arg Glu   Val Tyr Asp Tyr Tyr   Cys Arg Arg 
    32585                 32590                 32595             


Thr Met   Lys Lys Ile Lys Arg   Arg Thr Asp Thr Met   Arg Leu Leu 
    32600                 32605                 32610             


Glu Arg   Pro Pro Glu Phe Thr   Leu Pro Leu Tyr Asn   Lys Thr Ala 
    32615                 32620                 32625             


Tyr Val   Gly Glu Asn Val Arg   Phe Gly Val Thr Ile   Thr Val His 
    32630                 32635                 32640             


Pro Glu   Pro His Val Thr Trp   Tyr Lys Ser Gly Gln   Lys Ile Lys 
    32645                 32650                 32655             


Pro Gly   Asp Asn Asp Lys Lys   Tyr Thr Phe Glu Ser   Asp Lys Gly 
    32660                 32665                 32670             


Leu Tyr   Gln Leu Thr Ile Asn   Ser Val Thr Thr Asp   Asp Asp Ala 
    32675                 32680                 32685             


Glu Tyr   Thr Val Val Ala Arg   Asn Lys Tyr Gly Glu   Asp Ser Cys 
    32690                 32695                 32700             


Lys Ala   Lys Leu Thr Val Thr   Leu His Pro Pro Pro   Thr Asp Ser 
    32705                 32710                 32715             


Thr Leu   Arg Pro Met Phe Lys   Arg Leu Leu Ala Asn   Ala Glu Cys 
    32720                 32725                 32730             


Gln Glu   Gly Gln Ser Val Cys   Phe Glu Ile Arg Val   Ser Gly Ile 
    32735                 32740                 32745             


Pro Pro   Pro Thr Leu Lys Trp   Glu Lys Asp Gly Gln   Pro Leu Ser 
    32750                 32755                 32760             


Leu Gly   Pro Asn Ile Glu Ile   Ile His Glu Gly Leu   Asp Tyr Tyr 
    32765                 32770                 32775             


Ala Leu   His Ile Arg Asp Thr   Leu Pro Glu Asp Thr   Gly Tyr Tyr 
    32780                 32785                 32790             


Arg Val   Thr Ala Thr Asn Thr   Ala Gly Ser Thr Ser   Cys Gln Ala 
    32795                 32800                 32805             


His Leu   Gln Val Glu Arg Leu   Arg Tyr Lys Lys Gln   Glu Phe Lys 
    32810                 32815                 32820             


Ser Lys   Glu Glu His Glu Arg   His Val Gln Lys Gln   Ile Asp Lys 
    32825                 32830                 32835             


Thr Leu   Arg Met Ala Glu Ile   Leu Ser Gly Thr Glu   Ser Val Pro 
    32840                 32845                 32850             


Leu Thr   Gln Val Ala Lys Glu   Ala Leu Arg Glu Ala   Ala Val Leu 
    32855                 32860                 32865             


Tyr Lys   Pro Ala Val Ser Thr   Lys Thr Val Lys Gly   Glu Phe Arg 
    32870                 32875                 32880             


Leu Glu   Ile Glu Glu Lys Lys   Glu Glu Arg Lys Leu   Arg Met Pro 
    32885                 32890                 32895             


Tyr Asp   Val Pro Glu Pro Arg   Lys Tyr Lys Gln Thr   Thr Ile Glu 
    32900                 32905                 32910             


Glu Asp   Gln Arg Ile Lys Gln   Phe Val Pro Met Ser   Asp Met Lys 
    32915                 32920                 32925             


Trp Tyr   Lys Lys Ile Arg Asp   Gln Tyr Glu Met Pro   Gly Lys Leu 
    32930                 32935                 32940             


Asp Arg   Val Val Gln Lys Arg   Pro Lys Arg Ile Arg   Leu Ser Arg 
    32945                 32950                 32955             


Trp Glu   Gln Phe Tyr Val Met   Pro Leu Pro Arg Ile   Thr Asp Gln 
    32960                 32965                 32970             


Tyr Arg   Pro Lys Trp Arg Ile   Pro Lys Leu Ser Gln   Asp Asp Leu 
    32975                 32980                 32985             


Glu Ile   Val Arg Pro Ala Arg   Arg Arg Thr Pro Ser   Pro Asp Tyr 
    32990                 32995                 33000             


Asp Phe   Tyr Tyr Arg Pro Arg   Arg Arg Ser Leu Gly   Asp Ile Ser 
    33005                 33010                 33015             


Asp Glu   Glu Leu Leu Leu Pro   Ile Asp Asp Tyr Leu   Ala Met Lys 
    33020                 33025                 33030             


Arg Thr   Glu Glu Glu Arg Leu   Arg Leu Glu Glu Glu   Leu Glu Leu 
    33035                 33040                 33045             


Gly Phe   Ser Ala Ser Pro Pro   Ser Arg Ser Pro Pro   His Phe Glu 
    33050                 33055                 33060             


Leu Ser   Ser Leu Arg Tyr Ser   Ser Pro Gln Ala His   Val Lys Val 
    33065                 33070                 33075             


Glu Glu   Thr Arg Lys Asp Phe   Arg Tyr Ser Thr Tyr   His Ile Pro 
    33080                 33085                 33090             


Thr Lys   Ala Glu Ala Ser Thr   Ser Tyr Ala Glu Leu   Arg Glu Arg 
    33095                 33100                 33105             


His Ala   Gln Ala Ala Tyr Arg   Gln Pro Lys Gln Arg   Gln Arg Ile 
    33110                 33115                 33120             


Met Ala   Glu Arg Glu Asp Glu   Glu Leu Leu Arg Pro   Val Thr Thr 
    33125                 33130                 33135             


Thr Gln   His Leu Ser Glu Tyr   Lys Ser Glu Leu Asp   Phe Met Ser 
    33140                 33145                 33150             


Lys Glu   Glu Lys Ser Arg Lys   Lys Ser Arg Arg Gln   Arg Glu Val 
    33155                 33160                 33165             


Thr Glu   Ile Thr Glu Ile Glu   Glu Glu Tyr Glu Ile   Ser Lys His 
    33170                 33175                 33180             


Ala Gln   Arg Glu Ser Ser Ser   Ser Ala Ser Arg Leu   Leu Arg Arg 
    33185                 33190                 33195             


Arg Arg   Ser Leu Ser Pro Thr   Tyr Ile Glu Leu Met   Arg Pro Val 
    33200                 33205                 33210             


Ser Glu   Leu Ile Arg Ser Arg   Pro Gln Pro Ala Glu   Glu Tyr Glu 
    33215                 33220                 33225             


Asp Asp   Thr Glu Arg Arg Ser   Pro Thr Pro Glu Arg   Thr Arg Pro 
    33230                 33235                 33240             


Arg Ser   Pro Ser Pro Val Ser   Ser Glu Arg Ser Leu   Ser Arg Phe 
    33245                 33250                 33255             


Glu Arg   Ser Ala Arg Phe Asp   Ile Phe Ser Arg Tyr   Glu Ser Met 
    33260                 33265                 33270             


Lys Ala   Ala Leu Lys Thr Gln   Lys Thr Ser Glu Arg   Lys Tyr Glu 
    33275                 33280                 33285             


Val Leu   Ser Gln Gln Pro Phe   Thr Leu Asp His Ala   Pro Arg Ile 
    33290                 33295                 33300             


Thr Leu   Arg Met Arg Ser His   Arg Val Pro Cys Gly   Gln Asn Thr 
    33305                 33310                 33315             


Arg Phe   Ile Leu Asn Val Gln   Ser Lys Pro Thr Ala   Glu Val Lys 
    33320                 33325                 33330             


Trp Tyr   His Asn Gly Val Glu   Leu Gln Glu Ser Ser   Lys Ile His 
    33335                 33340                 33345             


Tyr Thr   Asn Thr Ser Gly Val   Leu Thr Leu Glu Ile   Leu Asp Cys 
    33350                 33355                 33360             


His Thr   Asp Asp Ser Gly Thr   Tyr Arg Ala Val Cys   Thr Asn Tyr 
    33365                 33370                 33375             


Lys Gly   Glu Ala Ser Asp Tyr   Ala Thr Leu Asp Val   Thr Gly Gly 
    33380                 33385                 33390             


Asp Tyr   Thr Thr Tyr Ala Ser   Gln Arg Arg Asp Glu   Glu Val Pro 
    33395                 33400                 33405             


Arg Ser   Val Phe Pro Glu Leu   Thr Arg Thr Glu Ala   Tyr Ala Val 
    33410                 33415                 33420             


Ser Ser   Phe Lys Lys Thr Ser   Glu Met Glu Ala Ser   Ser Ser Val 
    33425                 33430                 33435             


Arg Glu   Val Lys Ser Gln Met   Thr Glu Thr Arg Glu   Ser Leu Ser 
    33440                 33445                 33450             


Ser Tyr   Glu His Ser Ala Ser   Ala Glu Met Lys Ser   Ala Ala Leu 
    33455                 33460                 33465             


Glu Glu   Lys Ser Leu Glu Glu   Lys Ser Thr Thr Arg   Lys Ile Lys 
    33470                 33475                 33480             


Thr Thr   Leu Ala Ala Arg Ile   Leu Thr Lys Pro Arg   Ser Met Thr 
    33485                 33490                 33495             


Val Tyr   Glu Gly Glu Ser Ala   Arg Phe Ser Cys Asp   Thr Asp Gly 
    33500                 33505                 33510             


Glu Pro   Val Pro Thr Val Thr   Trp Leu Arg Lys Gly   Gln Val Leu 
    33515                 33520                 33525             


Ser Thr   Ser Ala Arg His Gln   Val Thr Thr Thr Lys   Tyr Lys Ser 
    33530                 33535                 33540             


Thr Phe   Glu Ile Ser Ser Val   Gln Ala Ser Asp Glu   Gly Asn Tyr 
    33545                 33550                 33555             


Ser Val   Val Val Glu Asn Ser   Glu Gly Lys Gln Glu   Ala Glu Phe 
    33560                 33565                 33570             


Thr Leu   Thr Ile Gln Lys Ala   Arg Val Thr Glu Lys   Ala Val Thr 
    33575                 33580                 33585             


Ser Pro   Pro Arg Val Lys Ser   Pro Glu Pro Arg Val   Lys Ser Pro 
    33590                 33595                 33600             


Glu Ala   Val Lys Ser Pro Lys   Arg Val Lys Ser Pro   Glu Pro Ser 
    33605                 33610                 33615             


His Pro   Lys Ala Val Ser Pro   Thr Glu Thr Lys Pro   Thr Pro Thr 
    33620                 33625                 33630             


Glu Lys   Val Gln His Leu Pro   Val Ser Ala Pro Pro   Lys Ile Thr 
    33635                 33640                 33645             


Gln Phe   Leu Lys Ala Glu Ala   Ser Lys Glu Ile Ala   Lys Leu Thr 
    33650                 33655                 33660             


Cys Val   Val Glu Ser Ser Val   Leu Arg Ala Lys Glu   Val Thr Trp 
    33665                 33670                 33675             


Tyr Lys   Asp Gly Lys Lys Leu   Lys Glu Asn Gly His   Phe Gln Phe 
    33680                 33685                 33690             


His Tyr   Ser Ala Asp Gly Thr   Tyr Glu Leu Lys Ile   Asn Asn Leu 
    33695                 33700                 33705             


Thr Glu   Ser Asp Gln Gly Glu   Tyr Val Cys Glu Ile   Ser Gly Glu 
    33710                 33715                 33720             


Gly Gly   Thr Ser Lys Thr Asn   Leu Gln Phe Met Gly   Gln Ala Phe 
    33725                 33730                 33735             


Lys Ser   Ile His Glu Lys Val   Ser Lys Ile Ser Glu   Thr Lys Lys 
    33740                 33745                 33750             


Ser Asp   Gln Lys Thr Thr Glu   Ser Thr Val Thr Arg   Lys Thr Glu 
    33755                 33760                 33765             


Pro Lys   Ala Pro Glu Pro Ile   Ser Ser Lys Pro Val   Ile Val Thr 
    33770                 33775                 33780             


Gly Leu   Gln Asp Thr Thr Val   Ser Ser Asp Ser Val   Ala Lys Phe 
    33785                 33790                 33795             


Ala Val   Lys Ala Thr Gly Glu   Pro Arg Pro Thr Ala   Ile Trp Thr 
    33800                 33805                 33810             


Lys Asp   Gly Lys Ala Ile Thr   Gln Gly Gly Lys Tyr   Lys Leu Ser 
    33815                 33820                 33825             


Glu Asp   Lys Gly Gly Phe Phe   Leu Glu Ile His Lys   Thr Asp Thr 
    33830                 33835                 33840             


Ser Asp   Ser Gly Leu Tyr Thr   Cys Thr Val Lys Asn   Ser Ala Gly 
    33845                 33850                 33855             


Ser Val   Ser Ser Ser Cys Lys   Leu Thr Ile Lys Ala   Ile Lys Asp 
    33860                 33865                 33870             


Thr Glu   Ala Gln Lys Val Ser   Thr Gln Lys Thr Ser   Glu Ile Thr 
    33875                 33880                 33885             


Pro Gln   Lys Lys Ala Val Val   Gln Glu Glu Ile Ser   Gln Lys Ala 
    33890                 33895                 33900             


Leu Arg   Ser Glu Glu Ile Lys   Met Ser Glu Ala Lys   Ser Gln Glu 
    33905                 33910                 33915             


Lys Leu   Ala Leu Lys Glu Glu   Ala Ser Lys Val Leu   Ile Ser Glu 
    33920                 33925                 33930             


Glu Val   Lys Lys Ser Ala Ala   Thr Ser Leu Glu Lys   Ser Ile Val 
    33935                 33940                 33945             


His Glu   Glu Ile Thr Lys Thr   Ser Gln Ala Ser Glu   Glu Val Arg 
    33950                 33955                 33960             


Thr His   Ala Glu Ile Lys Ala   Phe Ser Thr Gln Met   Ser Ile Asn 
    33965                 33970                 33975             


Glu Gly   Gln Arg Leu Val Leu   Lys Ala Asn Ile Ala   Gly Ala Thr 
    33980                 33985                 33990             


Asp Val   Lys Trp Val Leu Asn   Gly Val Glu Leu Thr   Asn Ser Glu 
    33995                 34000                 34005             


Glu Tyr   Arg Tyr Gly Val Ser   Gly Ser Asp Gln Thr   Leu Thr Ile 
    34010                 34015                 34020             


Lys Gln   Ala Ser His Arg Asp   Glu Gly Ile Leu Thr   Cys Ile Ser 
    34025                 34030                 34035             


Lys Thr   Lys Glu Gly Ile Val   Lys Cys Gln Tyr Asp   Leu Thr Leu 
    34040                 34045                 34050             


Ser Lys   Glu Leu Ser Asp Ala   Pro Ala Phe Ile Ser   Gln Pro Arg 
    34055                 34060                 34065             


Ser Gln   Asn Ile Asn Glu Gly   Gln Asn Val Leu Phe   Thr Cys Glu 
    34070                 34075                 34080             


Ile Ser   Gly Glu Pro Ser Pro   Glu Ile Glu Trp Phe   Lys Asn Asn 
    34085                 34090                 34095             


Leu Pro   Ile Ser Ile Ser Ser   Asn Val Ser Ile Ser   Arg Ser Arg 
    34100                 34105                 34110             


Asn Val   Tyr Ser Leu Glu Ile   Arg Asn Ala Ser Val   Ser Asp Ser 
    34115                 34120                 34125             


Gly Lys   Tyr Thr Ile Lys Ala   Lys Asn Phe Arg Gly   Gln Cys Ser 
    34130                 34135                 34140             


Ala Thr   Ala Ser Leu Met Val   Leu Pro Leu Val Glu   Glu Pro Ser 
    34145                 34150                 34155             


Arg Glu   Val Val Leu Arg Thr   Ser Gly Asp Thr Ser   Leu Gln Gly 
    34160                 34165                 34170             


Ser Phe   Ser Ser Gln Ser Val   Gln Met Ser Ala Ser   Lys Gln Glu 
    34175                 34180                 34185             


Ala Ser   Phe Ser Ser Phe Ser   Ser Ser Ser Ala Ser   Ser Met Thr 
    34190                 34195                 34200             


Glu Met   Lys Phe Ala Ser Met   Ser Ala Gln Ser Met   Ser Ser Met 
    34205                 34210                 34215             


Gln Glu   Ser Phe Val Glu Met   Ser Ser Ser Ser Phe   Met Gly Ile 
    34220                 34225                 34230             


Ser Asn   Met Thr Gln Leu Glu   Ser Ser Thr Ser Lys   Met Leu Lys 
    34235                 34240                 34245             


Ala Gly   Ile Arg Gly Ile Pro   Pro Lys Ile Glu Ala   Leu Pro Ser 
    34250                 34255                 34260             


Asp Ile   Ser Ile Asp Glu Gly   Lys Val Leu Thr Val   Ala Cys Ala 
    34265                 34270                 34275             


Phe Thr   Gly Glu Pro Thr Pro   Glu Val Thr Trp Ser   Cys Gly Gly 
    34280                 34285                 34290             


Arg Lys   Ile His Ser Gln Glu   Gln Gly Arg Phe His   Ile Glu Asn 
    34295                 34300                 34305             


Thr Asp   Asp Leu Thr Thr Leu   Ile Ile Met Asp Val   Gln Lys Gln 
    34310                 34315                 34320             


Asp Gly   Gly Leu Tyr Thr Leu   Ser Leu Gly Asn Glu   Phe Gly Ser 
    34325                 34330                 34335             


Asp Ser   Ala Thr Val Asn Ile   His Ile Arg Ser Ile   
    34340                 34345                 34350 


<210>  104
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Ala Glu Gln Ile Ile Gln Glu Ile Tyr Ser Gln Ile Gln Ser Lys 
1               5                   10                  15      


Lys Lys Ile Leu Ala Thr Pro Pro Gln Glu Asp Ala Pro Ser Val Asp 
            20                  25                  30          


Ile Ala Asn Ile Arg Met Pro Ser Leu Pro Ser Tyr Lys Val Gly Asp 
        35                  40                  45              


Lys Ile Ala Thr Arg Lys Ala Tyr Gly Gln Ala Leu Ala Lys Leu Gly 
    50                  55                  60                  


His Ala Ser Asp Arg Ile Ile Ala Leu Asp Gly Asp Thr Lys Asn Ser 
65                  70                  75                  80  


Thr Phe Ser Glu Ile Phe Lys Lys Glu His Pro Asp Arg Phe Ile Glu 
                85                  90                  95      


Cys Tyr Ile Ala Glu Gln Asn Met Val Ser Ile Ala Val Gly Cys Ala 
            100                 105                 110         


Thr Arg Asn Arg Thr Val Pro Phe Cys Ser Thr Phe Ala Ala Phe Phe 
        115                 120                 125             


Thr Arg Ala Phe Asp Gln Ile Arg Met Ala Ala Ile Ser Glu Ser Asn 
    130                 135                 140                 


Ile Asn Leu Cys Gly Ser His Cys Gly Val Ser Ile Gly Glu Asp Gly 
145                 150                 155                 160 


Pro Ser Gln Met Ala Leu Glu Asp Leu Ala Met Phe Arg Ser Val Pro 
                165                 170                 175     


Thr Ser Thr Val Phe Tyr Pro Ser Asp Gly Val Ala Thr Glu Lys Ala 
            180                 185                 190         


Val Glu Leu Ala Ala Asn Thr Lys Gly Ile Cys Phe Ile Arg Thr Ser 
        195                 200                 205             


Arg Pro Glu Asn Ala Ile Ile Tyr Asn Asn Asn Glu Asp Phe Gln Val 
    210                 215                 220                 


Gly Gln Ala Lys Val Val Leu Lys Ser Lys Asp Asp Gln Val Thr Val 
225                 230                 235                 240 


Ile Gly Ala Gly Val Thr Leu His Glu Ala Leu Ala Ala Ala Glu Leu 
                245                 250                 255     


Leu Lys Lys Glu Lys Ile Asn Ile Arg Val Leu Asp Pro Phe Thr Ile 
            260                 265                 270         


Lys Pro Leu Asp Arg Lys Leu Ile Leu Asp Ser Ala Arg Ala Thr Lys 
        275                 280                 285             


Gly Arg Ile Leu Thr Val Glu Asp His Tyr Tyr Glu Gly Gly Ile Gly 
    290                 295                 300                 


Glu Ala Val Ser Ser Ala Val Val Gly Glu Pro Gly Ile Thr Val Thr 
305                 310                 315                 320 


His Leu Ala Val Asn Arg Val Pro Arg Ser Gly Lys Pro Ala Glu Leu 
                325                 330                 335     


Leu Lys Met Phe Gly Ile Asp Arg Asp Ala Ile Ala Gln Ala Val Arg 
            340                 345                 350         


Gly Leu Ile Thr Lys Ala 
        355             


<210>  105
<211>  1383
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Tyr Ala Thr Asp Ser Arg Gly His Ser Pro Ala Phe Leu Gln Pro 
1               5                   10                  15      


Gln Asn Gly Asn Ser Arg His Pro Ser Gly Tyr Val Pro Gly Lys Val 
            20                  25                  30          


Val Pro Leu Arg Pro Pro Pro Pro Pro Lys Ser Gln Ala Ser Ala Lys 
        35                  40                  45              


Phe Thr Ser Ile Arg Arg Glu Asp Arg Ala Thr Phe Ala Phe Ser Pro 
    50                  55                  60                  


Glu Glu Gln Gln Ala Gln Arg Glu Ser Gln Lys Gln Lys Arg His Lys 
65                  70                  75                  80  


Asn Thr Phe Ile Cys Phe Ala Ile Thr Ser Phe Ser Phe Phe Ile Ala 
                85                  90                  95      


Leu Ala Ile Ile Leu Gly Ile Ser Ser Lys Tyr Ala Pro Asp Glu Asn 
            100                 105                 110         


Cys Pro Asp Gln Asn Pro Arg Leu Arg Asn Trp Asp Pro Gly Gln Asp 
        115                 120                 125             


Ser Ala Lys Gln Val Val Ile Lys Glu Gly Asp Met Leu Arg Leu Thr 
    130                 135                 140                 


Ser Asp Ala Thr Val His Ser Ile Val Ile Gln Asp Gly Gly Leu Leu 
145                 150                 155                 160 


Val Phe Gly Asp Asn Lys Asp Gly Ser Arg Asn Ile Thr Leu Arg Thr 
                165                 170                 175     


His Tyr Ile Leu Ile Gln Asp Gly Gly Ala Leu His Ile Gly Ala Glu 
            180                 185                 190         


Lys Cys Arg Tyr Lys Ser Lys Ala Thr Ile Thr Leu Tyr Gly Lys Ser 
        195                 200                 205             


Asp Glu Gly Glu Ser Met Pro Thr Phe Gly Lys Lys Phe Ile Gly Val 
    210                 215                 220                 


Glu Ala Gly Gly Thr Leu Glu Leu His Gly Ala Arg Lys Ala Ser Trp 
225                 230                 235                 240 


Thr Leu Leu Ala Arg Thr Leu Asn Ser Ser Gly Leu Pro Phe Gly Ser 
                245                 250                 255     


Tyr Thr Phe Glu Lys Asp Phe Ser Arg Gly Leu Asn Val Arg Val Ile 
            260                 265                 270         


Asp Gln Asp Thr Ala Lys Ile Leu Glu Ser Glu Arg Phe Asp Thr His 
        275                 280                 285             


Glu Tyr Arg Asn Glu Ser Arg Arg Leu Gln Glu Phe Leu Arg Phe Gln 
    290                 295                 300                 


Asp Pro Gly Arg Ile Val Ala Ile Ala Val Gly Asp Ser Ala Ala Lys 
305                 310                 315                 320 


Ser Leu Leu Gln Gly Thr Ile Gln Met Ile Gln Glu Arg Leu Gly Ser 
                325                 330                 335     


Glu Leu Ile Gln Gly Leu Gly Tyr Arg Gln Ala Trp Ala Leu Val Gly 
            340                 345                 350         


Val Ile Asp Gly Gly Ser Thr Ser Cys Asn Glu Ser Val Arg Asn Tyr 
        355                 360                 365             


Glu Asn His Ser Ser Gly Gly Lys Ala Leu Ala Gln Arg Glu Phe Tyr 
    370                 375                 380                 


Thr Val Asp Gly Gln Lys Phe Ser Val Thr Ala Tyr Ser Glu Trp Ile 
385                 390                 395                 400 


Glu Gly Val Ser Leu Ser Gly Phe Arg Val Glu Val Val Asp Gly Val 
                405                 410                 415     


Lys Leu Asn Leu Leu Asp Asp Val Ser Ser Trp Lys Pro Gly Asp Gln 
            420                 425                 430         


Ile Val Val Ala Ser Thr Asp Tyr Ser Met Tyr Gln Ala Glu Glu Phe 
        435                 440                 445             


Thr Leu Leu Pro Cys Ser Glu Cys Ser His Phe Gln Val Lys Val Lys 
    450                 455                 460                 


Glu Thr Pro Gln Phe Leu His Met Gly Glu Ile Ile Asp Gly Val Asp 
465                 470                 475                 480 


Met Arg Ala Glu Val Gly Ile Leu Thr Arg Asn Ile Val Ile Gln Gly 
                485                 490                 495     


Glu Val Glu Asp Ser Cys Tyr Ala Glu Asn Gln Cys Gln Phe Phe Asp 
            500                 505                 510         


Tyr Asp Thr Phe Gly Gly His Ile Met Ile Met Lys Asn Phe Thr Ser 
        515                 520                 525             


Val His Leu Ser Tyr Val Glu Leu Lys His Met Gly Gln Gln Gln Met 
    530                 535                 540                 


Gly Arg Tyr Pro Val His Phe His Leu Cys Gly Asp Val Asp Tyr Lys 
545                 550                 555                 560 


Gly Gly Tyr Arg His Ala Thr Phe Val Asp Gly Leu Ser Ile His His 
                565                 570                 575     


Ser Phe Ser Arg Cys Ile Thr Val His Gly Thr Asn Gly Leu Leu Ile 
            580                 585                 590         


Lys Asp Thr Ile Gly Phe Asp Thr Leu Gly His Cys Phe Phe Leu Glu 
        595                 600                 605             


Asp Gly Ile Glu Gln Arg Asn Thr Leu Phe His Asn Leu Gly Leu Leu 
    610                 615                 620                 


Thr Lys Pro Gly Thr Leu Leu Pro Thr Asp Arg Asn Asn Ser Met Cys 
625                 630                 635                 640 


Thr Thr Met Arg Asp Lys Val Phe Gly Asn Tyr Ile Pro Val Pro Ala 
                645                 650                 655     


Thr Asp Cys Met Ala Val Ser Thr Phe Trp Ile Ala His Pro Asn Asn 
            660                 665                 670         


Asn Leu Ile Asn Asn Ala Ala Ala Gly Ser Gln Asp Ala Gly Ile Trp 
        675                 680                 685             


Tyr Leu Phe His Lys Glu Pro Thr Gly Glu Ser Ser Gly Leu Gln Leu 
    690                 695                 700                 


Leu Ala Lys Pro Glu Leu Thr Pro Leu Gly Ile Phe Tyr Asn Asn Arg 
705                 710                 715                 720 


Val His Ser Asn Phe Lys Ala Gly Leu Phe Ile Asp Lys Gly Val Lys 
                725                 730                 735     


Thr Thr Asn Ser Ser Ala Ala Asp Pro Arg Glu Tyr Leu Cys Leu Asp 
            740                 745                 750         


Asn Ser Ala Arg Phe Arg Pro His Gln Asp Ala Asn Pro Glu Lys Pro 
        755                 760                 765             


Arg Val Ala Ala Leu Ile Asp Arg Leu Ile Ala Phe Lys Asn Asn Asp 
    770                 775                 780                 


Asn Gly Ala Trp Val Arg Gly Gly Asp Ile Ile Val Gln Asn Ser Ala 
785                 790                 795                 800 


Phe Ala Asp Asn Gly Ile Gly Leu Thr Phe Ala Ser Asp Gly Ser Phe 
                805                 810                 815     


Pro Ser Asp Glu Gly Ser Ser Gln Glu Val Ser Glu Ser Leu Phe Val 
            820                 825                 830         


Gly Glu Ser Arg Asn Tyr Gly Phe Gln Gly Gly Gln Asn Lys Tyr Val 
        835                 840                 845             


Gly Thr Gly Gly Ile Asp Gln Lys Pro Arg Thr Leu Pro Arg Asn Arg 
    850                 855                 860                 


Thr Phe Pro Ile Arg Gly Phe Gln Ile Tyr Asp Gly Pro Ile His Leu 
865                 870                 875                 880 


Thr Arg Ser Thr Phe Lys Lys Tyr Val Pro Thr Pro Asp Arg Tyr Ser 
                885                 890                 895     


Ser Ala Ile Gly Phe Leu Met Lys Asn Ser Trp Gln Ile Thr Pro Arg 
            900                 905                 910         


Asn Asn Ile Ser Leu Val Lys Phe Gly Pro His Val Ser Leu Asn Val 
        915                 920                 925             


Phe Phe Gly Lys Pro Gly Pro Trp Phe Glu Asp Cys Glu Met Asp Gly 
    930                 935                 940                 


Asp Lys Asn Ser Ile Phe His Asp Ile Asp Gly Ser Val Thr Gly Tyr 
945                 950                 955                 960 


Lys Asp Ala Tyr Val Gly Arg Met Asp Asn Tyr Leu Ile Arg His Pro 
                965                 970                 975     


Ser Cys Val Asn Val Ser Lys Trp Asn Ala Val Ile Cys Ser Gly Thr 
            980                 985                 990         


Tyr Ala Gln Val Tyr Val Gln Thr  Trp Ser Thr Gln Asn  Leu Ser Met 
        995                 1000                 1005             


Thr Ile  Thr Arg Asp Glu Tyr  Pro Ser Asn Pro Met  Val Leu Arg 
    1010                 1015                 1020             


Gly Ile  Asn Gln Lys Ala Ala  Phe Pro Gln Tyr Gln  Pro Val Val 
    1025                 1030                 1035             


Met Leu  Glu Lys Gly Tyr Thr  Ile His Trp Asn Gly  Pro Ala Pro 
    1040                 1045                 1050             


Arg Thr  Thr Phe Leu Tyr Leu  Val Asn Phe Asn Lys  Asn Asp Trp 
    1055                 1060                 1065             


Ile Arg  Val Gly Leu Cys Tyr  Pro Ser Asn Thr Ser  Phe Gln Val 
    1070                 1075                 1080             


Thr Phe  Gly Tyr Leu Gln Arg  Gln Asn Gly Ser Leu  Ser Lys Ile 
    1085                 1090                 1095             


Glu Glu  Tyr Glu Pro Val His  Ser Leu Glu Glu Leu  Gln Arg Lys 
    1100                 1105                 1110             


Gln Ser  Glu Arg Lys Phe Tyr  Phe Asp Ser Ser Thr  Gly Leu Leu 
    1115                 1120                 1125             


Phe Leu  Tyr Leu Lys Ala Lys  Ser His Arg His Gly  His Ser Tyr 
    1130                 1135                 1140             


Cys Ser  Ser Gln Gly Cys Glu  Arg Val Lys Ile Gln  Ala Ala Thr 
    1145                 1150                 1155             


Asp Ser  Lys Asp Ile Ser Asn  Cys Met Ala Lys Ala  Tyr Pro Gln 
    1160                 1165                 1170             


Tyr Tyr  Arg Lys Pro Ser Val  Val Lys Arg Met Pro  Ala Met Leu 
    1175                 1180                 1185             


Thr Gly  Leu Cys Gln Gly Cys  Gly Thr Arg Gln Val  Val Phe Thr 
    1190                 1195                 1200             


Ser Asp  Pro His Lys Ser Tyr  Leu Pro Val Gln Phe  Gln Ser Pro 
    1205                 1210                 1215             


Asp Lys  Ala Glu Thr Gln Arg  Gly Asp Pro Ser Val  Ile Ser Val 
    1220                 1225                 1230             


Asn Gly  Thr Asp Phe Thr Phe  Arg Ser Ala Gly Val  Leu Leu Leu 
    1235                 1240                 1245             


Val Val  Asp Pro Cys Ser Val  Pro Phe Arg Leu Thr  Glu Lys Thr 
    1250                 1255                 1260             


Val Phe  Pro Leu Ala Asp Val  Ser Arg Ile Glu Glu  Tyr Leu Lys 
    1265                 1270                 1275             


Thr Gly  Ile Pro Pro Arg Ser  Ile Val Leu Leu Ser  Thr Arg Gly 
    1280                 1285                 1290             


Glu Ile  Lys Gln Leu Asn Ile  Ser His Leu Leu Val  Pro Leu Gly 
    1295                 1300                 1305             


Leu Ala  Lys Pro Ala His Leu  Tyr Asp Lys Gly Ser  Thr Ile Phe 
    1310                 1315                 1320             


Leu Gly  Phe Ser Gly Asn Phe  Lys Pro Ser Trp Thr  Lys Leu Phe 
    1325                 1330                 1335             


Thr Ser  Pro Ala Gly Gln Gly  Leu Gly Val Leu Glu  Gln Phe Ile 
    1340                 1345                 1350             


Pro Leu  Gln Leu Asp Glu Tyr  Gly Cys Pro Arg Ala  Thr Thr Val 
    1355                 1360                 1365             


Arg Arg  Arg Asp Leu Glu Leu  Leu Lys Gln Ala Ser  Lys Ala His 
    1370                 1375                 1380             


<210>  106
<211>  621
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Ile Ala Thr Gly Gly Leu Leu Arg Ile Ser Ala Arg Lys Gln Asp 
1               5                   10                  15      


Pro Leu Arg Pro Pro Ser Gln Ile Pro Lys Arg Lys Arg Lys Ala Lys 
            20                  25                  30          


Lys Arg Arg Lys Asn Asp Val Val Val Val Lys Gly Lys Leu Lys Leu 
        35                  40                  45              


Cys Ser Ile Ser Gly Leu Ile Ala Leu Cys Gly Ile Leu Val Leu Leu 
    50                  55                  60                  


Val Gly Ile Ala Met Ala Val Val Gly Tyr Trp Pro Lys Ala Thr Gly 
65                  70                  75                  80  


Thr Asn Arg Glu Gly Gly Lys Gln Leu Pro Pro Ala Gly Ser Ser His 
                85                  90                  95      


Arg Val Pro Thr Thr Ala Asn Ser Ser Ser Ser Gly Ser Lys Asn Arg 
            100                 105                 110         


Ser Arg Ser His Pro Arg Ala Pro Gly Gly Val Asn Ser Ser Ser Ala 
        115                 120                 125             


Gly Ala Pro Arg Ser Thr Pro Pro Ala Arg Ala Ala Ser Pro Ser Ser 
    130                 135                 140                 


Ser Ser Thr Ser Val Gly Phe Phe Phe Arg Ile Phe Ser Gly Tyr Leu 
145                 150                 155                 160 


His Ser Asp Lys Leu Lys Val Phe Gly Pro Leu Ile Met Gly Ile Gly 
                165                 170                 175     


Ile Phe Leu Phe Ile Cys Ala Asn Ala Val Leu His Glu Asn Arg Asp 
            180                 185                 190         


Lys Lys Thr Lys Ile Ile Asn Leu Arg Asp Leu Tyr Ser Thr Val Ile 
        195                 200                 205             


Asp Val His Ser Leu Arg Ala Lys Asp Leu Ala Ala Ala Ala Ala Ala 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Ser Ser Ser Ser Ser Ala Pro Ala Ala Ala 
225                 230                 235                 240 


Pro Pro Gly Ala Ile Pro Leu Asn Gly Phe Leu Ser Tyr Val Gln Ser 
                245                 250                 255     


Arg Gly Leu Glu Leu Lys Pro Gly Gly Cys Gly Gly Ser Gly Asp Ala 
            260                 265                 270         


Phe Gly Ala Ala Ala Met Leu Ala Lys Gly Ser Trp Pro Pro His Pro 
        275                 280                 285             


Ala Ala Pro Ser Gly Gly Arg Pro Arg Gly Ala Ala Ser Pro Pro Asp 
    290                 295                 300                 


Leu Ala Ser Ser Pro Arg Cys Pro Arg Glu Pro Pro Ser Leu Ala Glu 
305                 310                 315                 320 


Ala Val Tyr Ser Val Tyr Arg Glu Arg Ser Gly Val Ala Gly Ser Arg 
                325                 330                 335     


Arg Ala Ala Ala Ala Thr Ala Ala Ala Ala Ala Ser Ser Cys Ser Ser 
            340                 345                 350         


Pro Ala Pro Cys Ser Pro Pro Glu Ser Trp Gly Arg Gln Ser Thr Ala 
        355                 360                 365             


Ser Ser Phe Val Asp Ser Ser Leu Ser Ala Phe Ala Leu Leu Pro Leu 
    370                 375                 380                 


Gln Gly Gly Arg Asp Arg Gly Gly Asp Ala Glu Gly Ala Ser Cys Ser 
385                 390                 395                 400 


Trp Gln Arg Pro Pro Gly Glu Arg Gly Ser Gln Glu Ile Pro Arg Gly 
                405                 410                 415     


Glu Leu Asp Leu Ser Met Thr Asn Leu Arg Gly Ala Glu Gly Ser Met 
            420                 425                 430         


Arg Gly Ala Arg Arg Glu Pro Glu Glu Pro Glu Gly Ala Val Ala Ala 
        435                 440                 445             


Arg Ala Ala Arg Gly Gln Gly Gly Arg Leu Pro Arg Thr Gly Arg Tyr 
    450                 455                 460                 


Ala Ala Leu Arg Arg Arg Ser Thr Ser Gly Leu Pro Asp Tyr Arg Ala 
465                 470                 475                 480 


Pro Pro Ser Pro Glu Pro Pro Pro Ser Pro Gly Ser Ala Asp Pro Asp 
                485                 490                 495     


Ser Ser Pro Leu Ala Lys Ala Ala Ser Pro Ser Pro Pro Leu Arg Leu 
            500                 505                 510         


Glu Gly Ser Pro Pro Thr Arg Arg Asp Ser Gly Ser Ser Gln Ser Asp 
        515                 520                 525             


Asp Pro Ser Ser Ser Asn Lys Gly Tyr Thr Pro Leu Arg Glu Ala Gly 
    530                 535                 540                 


Thr Ser Thr Glu Ser Val Leu Asp Ala Val Ala Gly Gln Thr Arg Asp 
545                 550                 555                 560 


Ser Ala Val Ala Ala Pro Val Leu Gly Ala Glu Gln Ser Ser Pro Glu 
                565                 570                 575     


Gly Ala Ser Gln Glu Pro Pro Thr Ala Glu Gln Pro Gln Pro Val Gln 
            580                 585                 590         


Arg Gln Phe Thr Asn Lys Glu Lys Leu Ile Met Ile Ser Arg Ser His 
        595                 600                 605             


Ala Ile Gly Val Glu Glu Glu Leu Glu Ser Thr Gly Ile 
    610                 615                 620     


<210>  107
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Thr Met Asp Lys Ser Glu Leu Val Gln Lys Ala Lys Leu Ala Glu 
1               5                   10                  15      


Gln Ala Glu Arg Tyr Asp Asp Met Ala Ala Ala Met Lys Ala Val Thr 
            20                  25                  30          


Glu Gln Gly His Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val 
        35                  40                  45              


Ala Tyr Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Ile 
    50                  55                  60                  


Ser Ser Ile Glu Gln Lys Thr Glu Arg Asn Glu Lys Lys Gln Gln Met 
65                  70                  75                  80  


Gly Lys Glu Tyr Arg Glu Lys Ile Glu Ala Glu Leu Gln Asp Ile Cys 
                85                  90                  95      


Asn Asp Val Leu Glu Leu Leu Asp Lys Tyr Leu Ile Pro Asn Ala Thr 
            100                 105                 110         


Gln Pro Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Phe 
        115                 120                 125             


Arg Tyr Leu Ser Glu Val Ala Ser Gly Asp Asn Lys Gln Thr Thr Val 
    130                 135                 140                 


Ser Asn Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys 
145                 150                 155                 160 


Glu Met Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe 
                165                 170                 175     


Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser 
            180                 185                 190         


Leu Ala Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu 
        195                 200                 205             


Asn Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg 
    210                 215                 220                 


Asp Asn Leu Thr Leu Trp Thr Ser Glu Asn Gln Gly Asp Glu Gly Asp 
225                 230                 235                 240 


Ala Gly Glu Gly Glu Asn 
                245     


<210>  108
<211>  1123
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Asp Leu Gly Pro Gly Asp Ala Ala Gly Gly Gly Pro Leu Ala Pro 
1               5                   10                  15      


Arg Pro Arg Arg Arg Arg Ser Leu Arg Arg Leu Phe Ser Arg Phe Leu 
            20                  25                  30          


Leu Ala Leu Gly Ser Arg Ser Arg Pro Gly Asp Ser Pro Pro Arg Pro 
        35                  40                  45              


Gln Pro Gly His Cys Asp Gly Asp Gly Glu Gly Gly Phe Ala Cys Ala 
    50                  55                  60                  


Pro Gly Pro Val Pro Ala Ala Pro Gly Ser Pro Gly Glu Glu Arg Pro 
65                  70                  75                  80  


Pro Gly Pro Gln Pro Gln Leu Gln Leu Pro Ala Gly Asp Gly Ala Arg 
                85                  90                  95      


Pro Pro Gly Ala Gln Gly Leu Lys Asn His Gly Asn Thr Cys Phe Met 
            100                 105                 110         


Asn Ala Val Val Gln Cys Leu Ser Asn Thr Asp Leu Leu Ala Glu Phe 
        115                 120                 125             


Leu Ala Leu Gly Arg Tyr Arg Ala Ala Pro Gly Arg Ala Glu Val Thr 
    130                 135                 140                 


Glu Gln Leu Ala Ala Leu Val Arg Ala Leu Trp Thr Arg Glu Tyr Thr 
145                 150                 155                 160 


Pro Gln Leu Ser Ala Glu Phe Lys Asn Ala Val Ser Lys Tyr Gly Ser 
                165                 170                 175     


Gln Phe Gln Gly Asn Ser Gln His Asp Ala Leu Glu Phe Leu Leu Trp 
            180                 185                 190         


Leu Leu Asp Arg Val His Glu Asp Leu Glu Gly Ser Ser Arg Gly Pro 
        195                 200                 205             


Val Ser Glu Lys Leu Pro Pro Glu Ala Thr Lys Thr Ser Glu Asn Cys 
    210                 215                 220                 


Leu Ser Pro Ser Ala Gln Leu Pro Leu Gly Gln Ser Phe Val Gln Ser 
225                 230                 235                 240 


His Phe Gln Ala Gln Tyr Arg Ser Ser Leu Thr Cys Pro His Cys Leu 
                245                 250                 255     


Lys Gln Ser Asn Thr Phe Asp Pro Phe Leu Cys Val Ser Leu Pro Ile 
            260                 265                 270         


Pro Leu Arg Gln Thr Arg Phe Leu Ser Val Thr Leu Val Phe Pro Ser 
        275                 280                 285             


Lys Ser Gln Arg Phe Leu Arg Val Gly Leu Ala Val Pro Ile Leu Ser 
    290                 295                 300                 


Thr Val Ala Ala Leu Arg Lys Met Val Ala Glu Glu Gly Gly Val Pro 
305                 310                 315                 320 


Ala Asp Glu Val Ile Leu Val Glu Leu Tyr Pro Ser Gly Phe Gln Arg 
                325                 330                 335     


Ser Phe Phe Asp Glu Glu Asp Leu Asn Thr Ile Ala Glu Gly Asp Asn 
            340                 345                 350         


Val Tyr Ala Phe Gln Val Pro Pro Ser Pro Ser Gln Gly Thr Leu Ser 
        355                 360                 365             


Ala His Pro Leu Gly Leu Ser Ala Ser Pro Arg Leu Ala Ala Arg Glu 
    370                 375                 380                 


Gly Gln Arg Phe Ser Leu Ser Leu His Ser Glu Ser Lys Val Leu Ile 
385                 390                 395                 400 


Leu Phe Cys Asn Leu Val Gly Ser Gly Gln Gln Ala Ser Arg Phe Gly 
                405                 410                 415     


Pro Pro Phe Leu Ile Arg Glu Asp Arg Ala Val Ser Trp Ala Gln Leu 
            420                 425                 430         


Gln Gln Ser Ile Leu Ser Lys Val Arg His Leu Met Lys Ser Glu Ala 
        435                 440                 445             


Pro Val Gln Asn Leu Gly Ser Leu Phe Ser Ile Arg Val Val Gly Leu 
    450                 455                 460                 


Ser Val Ala Cys Ser Tyr Leu Ser Pro Lys Asp Ser Arg Pro Leu Cys 
465                 470                 475                 480 


His Trp Ala Val Asp Arg Val Leu His Leu Arg Arg Pro Gly Gly Pro 
                485                 490                 495     


Pro His Val Lys Leu Ala Val Glu Trp Asp Ser Ser Val Lys Glu Arg 
            500                 505                 510         


Leu Phe Gly Ser Leu Gln Glu Glu Arg Ala Gln Asp Ala Asp Ser Val 
        515                 520                 525             


Trp Gln Gln Gln Gln Ala His Gln Gln His Ser Cys Thr Leu Asp Glu 
    530                 535                 540                 


Cys Phe Gln Phe Tyr Thr Lys Glu Glu Gln Leu Ala Gln Asp Asp Ala 
545                 550                 555                 560 


Trp Lys Cys Pro His Cys Gln Val Leu Gln Gln Gly Met Val Lys Leu 
                565                 570                 575     


Ser Leu Trp Thr Leu Pro Asp Ile Leu Ile Ile His Leu Lys Arg Phe 
            580                 585                 590         


Cys Gln Val Gly Glu Arg Arg Asn Lys Leu Ser Thr Leu Val Lys Phe 
        595                 600                 605             


Pro Leu Ser Gly Leu Asn Met Ala Pro His Val Ala Gln Arg Ser Thr 
    610                 615                 620                 


Ser Pro Glu Ala Gly Leu Gly Pro Trp Pro Ser Trp Lys Gln Pro Asp 
625                 630                 635                 640 


Cys Leu Pro Thr Ser Tyr Pro Leu Asp Phe Leu Tyr Asp Leu Tyr Ala 
                645                 650                 655     


Val Cys Asn His His Gly Asn Leu Gln Gly Gly His Tyr Thr Ala Tyr 
            660                 665                 670         


Cys Arg Asn Ser Leu Asp Gly Gln Trp Tyr Ser Tyr Asp Asp Ser Thr 
        675                 680                 685             


Val Glu Pro Leu Arg Glu Asp Glu Val Asn Thr Arg Gly Ala Tyr Ile 
    690                 695                 700                 


Leu Phe Tyr Gln Lys Arg Asn Ser Ile Pro Pro Trp Ser Ala Ser Ser 
705                 710                 715                 720 


Ser Met Arg Gly Ser Thr Ser Ser Ser Leu Ser Asp His Trp Leu Leu 
                725                 730                 735     


Arg Leu Gly Ser His Ala Gly Ser Thr Arg Gly Ser Leu Leu Ser Trp 
            740                 745                 750         


Ser Ser Ala Pro Cys Pro Ser Leu Pro Gln Val Pro Asp Ser Pro Ile 
        755                 760                 765             


Phe Thr Asn Ser Leu Cys Asn Gln Glu Lys Gly Gly Leu Glu Pro Arg 
    770                 775                 780                 


Arg Leu Val Arg Gly Val Lys Gly Arg Ser Ile Ser Met Lys Ala Pro 
785                 790                 795                 800 


Thr Thr Ser Arg Ala Lys Gln Gly Pro Phe Lys Thr Met Pro Leu Arg 
                805                 810                 815     


Trp Ser Phe Gly Ser Lys Glu Lys Pro Pro Gly Ala Ser Val Glu Leu 
            820                 825                 830         


Val Glu Tyr Leu Glu Ser Arg Arg Arg Pro Arg Ser Thr Ser Gln Ser 
        835                 840                 845             


Ile Val Ser Leu Leu Thr Gly Thr Ala Gly Glu Asp Glu Lys Ser Ala 
    850                 855                 860                 


Ser Pro Arg Ser Asn Val Ala Leu Pro Ala Asn Ser Glu Asp Gly Gly 
865                 870                 875                 880 


Arg Ala Ile Glu Arg Gly Pro Ala Gly Val Pro Cys Pro Ser Ala Gln 
                885                 890                 895     


Pro Asn His Cys Leu Ala Pro Gly Asn Ser Asp Gly Pro Asn Thr Ala 
            900                 905                 910         


Arg Lys Leu Lys Glu Asn Ala Gly Gln Asp Ile Lys Leu Pro Arg Lys 
        915                 920                 925             


Phe Asp Leu Pro Leu Thr Val Met Pro Ser Val Glu His Glu Lys Pro 
    930                 935                 940                 


Ala Arg Pro Glu Gly Gln Lys Ala Met Asn Trp Lys Glu Ser Phe Gln 
945                 950                 955                 960 


Met Gly Ser Lys Ser Ser Pro Pro Ser Pro Tyr Met Gly Phe Ser Gly 
                965                 970                 975     


Asn Ser Lys Asp Ser Arg Arg Gly Thr Ser Glu Leu Asp Arg Pro Leu 
            980                 985                 990         


Gln Gly Thr Leu Thr Leu Leu Arg  Ser Val Phe Arg Lys  Lys Glu Asn 
        995                 1000                 1005             


Arg Arg  Asn Glu Arg Ala Glu  Val Ser Pro Gln Val  Pro Pro Val 
    1010                 1015                 1020             


Ser Leu  Val Ser Gly Gly Leu  Ser Pro Ala Met Asp  Gly Gln Ala 
    1025                 1030                 1035             


Pro Gly  Ser Pro Pro Ala Leu  Arg Ile Pro Glu Gly  Leu Ala Arg 
    1040                 1045                 1050             


Gly Leu  Gly Ser Arg Leu Glu  Arg Asp Val Trp Ser  Ala Pro Ser 
    1055                 1060                 1065             


Ser Leu  Arg Leu Pro Arg Lys  Ala Ser Arg Ala Pro  Arg Gly Ser 
    1070                 1075                 1080             


Ala Leu  Gly Met Ser Gln Arg  Thr Val Pro Gly Glu  Gln Ala Ser 
    1085                 1090                 1095             


Tyr Gly  Thr Phe Gln Arg Val  Lys Tyr His Thr Leu  Ser Leu Gly 
    1100                 1105                 1110             


Arg Lys  Lys Thr Leu Pro Glu  Ser Ser Phe 
    1115                 1120             


<210>  109
<211>  1058
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Ser Ser Ser Pro Leu Ser Lys Lys Arg Arg Val Ser Gly Pro Asp 
1               5                   10                  15      


Pro Lys Pro Gly Ser Asn Cys Ser Pro Ala Gln Ser Val Leu Ser Glu 
            20                  25                  30          


Val Pro Ser Val Pro Thr Asn Gly Met Ala Lys Asn Gly Ser Glu Ala 
        35                  40                  45              


Asp Ile Asp Glu Gly Leu Tyr Ser Arg Gln Leu Tyr Val Leu Gly His 
    50                  55                  60                  


Glu Ala Met Lys Arg Leu Gln Thr Ser Ser Val Leu Val Ser Gly Leu 
65                  70                  75                  80  


Arg Gly Leu Gly Val Glu Ile Ala Lys Asn Ile Ile Leu Gly Gly Val 
                85                  90                  95      


Lys Ala Val Thr Leu His Asp Gln Gly Thr Ala Gln Trp Ala Asp Leu 
            100                 105                 110         


Ser Ser Gln Phe Tyr Leu Arg Glu Glu Asp Ile Gly Lys Asn Arg Ala 
        115                 120                 125             


Glu Val Ser Gln Pro Arg Leu Ala Glu Leu Asn Ser Tyr Val Pro Val 
    130                 135                 140                 


Thr Ala Tyr Thr Gly Pro Leu Val Glu Asp Phe Leu Ser Gly Phe Gln 
145                 150                 155                 160 


Val Val Val Leu Thr Asn Thr Pro Leu Glu Asp Gln Leu Arg Val Gly 
                165                 170                 175     


Glu Phe Cys His Asn Arg Gly Ile Lys Leu Val Val Ala Asp Thr Arg 
            180                 185                 190         


Gly Leu Phe Gly Gln Leu Phe Cys Asp Phe Gly Glu Glu Met Ile Leu 
        195                 200                 205             


Thr Asp Ser Asn Gly Glu Gln Pro Leu Ser Ala Met Val Ser Met Val 
    210                 215                 220                 


Thr Lys Asp Asn Pro Gly Val Val Thr Cys Leu Asp Glu Ala Arg His 
225                 230                 235                 240 


Gly Phe Glu Ser Gly Asp Phe Val Ser Phe Ser Glu Val Gln Gly Met 
                245                 250                 255     


Val Glu Leu Asn Gly Asn Gln Pro Met Glu Ile Lys Val Leu Gly Pro 
            260                 265                 270         


Tyr Thr Phe Ser Ile Cys Asp Thr Ser Asn Phe Ser Asp Tyr Ile Arg 
        275                 280                 285             


Gly Gly Ile Val Ser Gln Val Lys Val Pro Lys Lys Ile Ser Phe Lys 
    290                 295                 300                 


Ser Leu Val Ala Ser Leu Ala Glu Pro Asp Phe Val Val Thr Asp Phe 
305                 310                 315                 320 


Ala Lys Phe Ser Arg Pro Ala Gln Leu His Ile Gly Phe Gln Ala Leu 
                325                 330                 335     


His Gln Phe Cys Ala Gln His Gly Arg Pro Pro Arg Pro Arg Asn Glu 
            340                 345                 350         


Glu Asp Ala Ala Glu Leu Val Ala Leu Ala Gln Ala Val Asn Ala Arg 
        355                 360                 365             


Ala Leu Pro Ala Val Gln Gln Asn Asn Leu Asp Glu Asp Leu Ile Arg 
    370                 375                 380                 


Lys Leu Ala Tyr Val Ala Ala Gly Asp Leu Ala Pro Ile Asn Ala Phe 
385                 390                 395                 400 


Ile Gly Gly Leu Ala Ala Gln Glu Val Met Lys Ala Cys Ser Gly Lys 
                405                 410                 415     


Phe Met Pro Ile Met Gln Trp Leu Tyr Phe Asp Ala Leu Glu Cys Leu 
            420                 425                 430         


Pro Glu Asp Lys Glu Val Leu Thr Glu Asp Lys Cys Leu Gln Arg Gln 
        435                 440                 445             


Asn Arg Tyr Asp Gly Gln Val Ala Val Phe Gly Ser Asp Leu Gln Glu 
    450                 455                 460                 


Lys Leu Gly Lys Gln Lys Tyr Phe Leu Val Gly Ala Gly Ala Ile Gly 
465                 470                 475                 480 


Cys Glu Leu Leu Lys Asn Phe Ala Met Ile Gly Leu Gly Cys Gly Glu 
                485                 490                 495     


Gly Gly Glu Ile Ile Val Thr Asp Met Asp Thr Ile Glu Lys Ser Asn 
            500                 505                 510         


Leu Asn Arg Gln Phe Leu Phe Arg Pro Trp Asp Val Thr Lys Leu Lys 
        515                 520                 525             


Ser Asp Thr Ala Ala Ala Ala Val Arg Gln Met Asn Pro His Ile Arg 
    530                 535                 540                 


Val Thr Ser His Gln Asn Arg Val Gly Pro Asp Thr Glu Arg Ile Tyr 
545                 550                 555                 560 


Asp Asp Asp Phe Phe Gln Asn Leu Asp Gly Val Ala Asn Ala Leu Asp 
                565                 570                 575     


Asn Val Asp Ala Arg Met Tyr Met Asp Arg Arg Cys Val Tyr Tyr Arg 
            580                 585                 590         


Lys Pro Leu Leu Glu Ser Gly Thr Leu Gly Thr Lys Gly Asn Val Gln 
        595                 600                 605             


Val Val Ile Pro Phe Leu Thr Glu Ser Tyr Ser Ser Ser Gln Asp Pro 
    610                 615                 620                 


Pro Glu Lys Ser Ile Pro Ile Cys Thr Leu Lys Asn Phe Pro Asn Ala 
625                 630                 635                 640 


Ile Glu His Thr Leu Gln Trp Ala Arg Asp Glu Phe Glu Gly Leu Phe 
                645                 650                 655     


Lys Gln Pro Ala Glu Asn Val Asn Gln Tyr Leu Thr Asp Pro Lys Phe 
            660                 665                 670         


Val Glu Arg Thr Leu Arg Leu Ala Gly Thr Gln Pro Leu Glu Val Leu 
        675                 680                 685             


Glu Ala Val Gln Arg Ser Leu Val Leu Gln Arg Pro Gln Thr Trp Ala 
    690                 695                 700                 


Asp Cys Val Thr Trp Ala Cys His His Trp His Thr Gln Tyr Ser Asn 
705                 710                 715                 720 


Asn Ile Arg Gln Leu Leu His Asn Phe Pro Pro Asp Gln Leu Thr Ser 
                725                 730                 735     


Ser Gly Ala Pro Phe Trp Ser Gly Pro Lys Arg Cys Pro His Pro Leu 
            740                 745                 750         


Thr Phe Asp Val Asn Asn Pro Leu His Leu Asp Tyr Val Met Ala Ala 
        755                 760                 765             


Ala Asn Leu Phe Ala Gln Thr Tyr Gly Leu Thr Gly Ser Gln Asp Arg 
    770                 775                 780                 


Ala Ala Val Ala Thr Phe Leu Gln Ser Val Gln Val Pro Glu Phe Thr 
785                 790                 795                 800 


Pro Lys Ser Gly Val Lys Ile His Val Ser Asp Gln Glu Leu Gln Ser 
                805                 810                 815     


Ala Asn Ala Ser Val Asp Asp Ser Arg Leu Glu Glu Leu Lys Ala Thr 
            820                 825                 830         


Leu Pro Ser Pro Asp Lys Leu Pro Gly Phe Lys Met Tyr Pro Ile Asp 
        835                 840                 845             


Phe Glu Lys Asp Asp Asp Ser Asn Phe His Met Asp Phe Ile Val Ala 
    850                 855                 860                 


Ala Ser Asn Leu Arg Ala Glu Asn Tyr Asp Ile Pro Ser Ala Asp Arg 
865                 870                 875                 880 


His Lys Ser Lys Leu Ile Ala Gly Lys Ile Ile Pro Ala Ile Ala Thr 
                885                 890                 895     


Thr Thr Ala Ala Val Val Gly Leu Val Cys Leu Glu Leu Tyr Lys Val 
            900                 905                 910         


Val Gln Gly His Arg Gln Leu Asp Ser Tyr Lys Asn Gly Phe Leu Asn 
        915                 920                 925             


Leu Ala Leu Pro Phe Phe Gly Phe Ser Glu Pro Leu Ala Ala Pro Arg 
    930                 935                 940                 


His Gln Tyr Tyr Asn Gln Glu Trp Thr Leu Trp Asp Arg Phe Glu Val 
945                 950                 955                 960 


Gln Gly Leu Gln Pro Asn Gly Glu Glu Met Thr Leu Lys Gln Phe Leu 
                965                 970                 975     


Asp Tyr Phe Lys Thr Glu His Lys Leu Glu Ile Thr Met Leu Ser Gln 
            980                 985                 990         


Gly Val Ser Met Leu Tyr Ser Phe  Phe Met Pro Ala Ala  Lys Leu Lys 
        995                 1000                 1005             


Glu Arg  Leu Asp Gln Pro Met  Thr Glu Ile Val Ser  Arg Val Ser 
    1010                 1015                 1020             


Lys Arg  Lys Leu Gly Arg His  Val Arg Ala Leu Val  Leu Glu Leu 
    1025                 1030                 1035             


Cys Cys  Asn Asp Glu Ser Gly  Glu Asp Val Glu Val  Pro Tyr Val 
    1040                 1045                 1050             


Arg Tyr  Thr Ile Arg 
    1055             


<210>  110
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Ala Pro Leu Gly Tyr Phe Leu Leu Leu Cys Ser Leu Lys Gln Ala 
1               5                   10                  15      


Leu Gly Ser Tyr Pro Ile Trp Trp Ser Leu Ala Val Gly Pro Gln Tyr 
            20                  25                  30          


Ser Ser Leu Gly Ser Gln Pro Ile Leu Cys Ala Ser Ile Pro Gly Leu 
        35                  40                  45              


Val Pro Lys Gln Leu Arg Phe Cys Arg Asn Tyr Val Glu Ile Met Pro 
    50                  55                  60                  


Ser Val Ala Glu Gly Ile Lys Ile Gly Ile Gln Glu Cys Gln His Gln 
65                  70                  75                  80  


Phe Arg Gly Arg Arg Trp Asn Cys Thr Thr Val His Asp Ser Leu Ala 
                85                  90                  95      


Ile Phe Gly Pro Val Leu Asp Lys Ala Thr Arg Glu Ser Ala Phe Val 
            100                 105                 110         


His Ala Ile Ala Ser Ala Gly Val Ala Phe Ala Val Thr Arg Ser Cys 
        115                 120                 125             


Ala Glu Gly Thr Ala Ala Ile Cys Gly Cys Ser Ser Arg His Gln Gly 
    130                 135                 140                 


Ser Pro Gly Lys Gly Trp Lys Trp Gly Gly Cys Ser Glu Asp Ile Glu 
145                 150                 155                 160 


Phe Gly Gly Met Val Ser Arg Glu Phe Ala Asp Ala Arg Glu Asn Arg 
                165                 170                 175     


Pro Asp Ala Arg Ser Ala Met Asn Arg His Asn Asn Glu Ala Gly Arg 
            180                 185                 190         


Gln Ala Ile Ala Ser His Met His Leu Lys Cys Lys Cys His Gly Leu 
        195                 200                 205             


Ser Gly Ser Cys Glu Val Lys Thr Cys Trp Trp Ser Gln Pro Asp Phe 
    210                 215                 220                 


Arg Ala Ile Gly Asp Phe Leu Lys Asp Lys Tyr Asp Ser Ala Ser Glu 
225                 230                 235                 240 


Met Val Val Glu Lys His Arg Glu Ser Arg Gly Trp Val Glu Thr Leu 
                245                 250                 255     


Arg Pro Arg Tyr Thr Tyr Phe Lys Val Pro Thr Glu Arg Asp Leu Val 
            260                 265                 270         


Tyr Tyr Glu Ala Ser Pro Asn Phe Cys Glu Pro Asn Pro Glu Thr Gly 
        275                 280                 285             


Ser Phe Gly Thr Arg Asp Arg Thr Cys Asn Val Ser Ser His Gly Ile 
    290                 295                 300                 


Asp Gly Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn Ala Arg Ala 
305                 310                 315                 320 


Glu Arg Arg Arg Glu Lys Cys Arg Cys Val Phe His Trp Cys Cys Tyr 
                325                 330                 335     


Val Ser Cys Gln Glu Cys Thr Arg Val Tyr Asp Val His Thr Cys Lys 
            340                 345                 350         


<210>  111
<211>  732
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Val Arg Ser Gly Asn Lys Ala Ala Val Val Leu Cys Met Asp Val 
1               5                   10                  15      


Gly Phe Thr Met Ser Asn Ser Ile Pro Gly Ile Glu Ser Pro Phe Glu 
            20                  25                  30          


Gln Ala Lys Lys Val Ile Thr Met Phe Val Gln Arg Gln Val Phe Ala 
        35                  40                  45              


Glu Asn Lys Asp Glu Ile Ala Leu Val Leu Phe Gly Thr Asp Gly Thr 
    50                  55                  60                  


Asp Asn Pro Leu Ser Gly Gly Asp Gln Tyr Gln Asn Ile Thr Val His 
65                  70                  75                  80  


Arg His Leu Met Leu Pro Asp Phe Asp Leu Leu Glu Asp Ile Glu Ser 
                85                  90                  95      


Lys Ile Gln Pro Gly Ser Gln Gln Ala Asp Phe Leu Asp Ala Leu Ile 
            100                 105                 110         


Val Ser Met Asp Val Ile Gln His Glu Thr Ile Gly Lys Lys Phe Glu 
        115                 120                 125             


Lys Arg His Ile Glu Ile Phe Thr Asp Leu Ser Ser Arg Phe Ser Lys 
    130                 135                 140                 


Ser Gln Leu Asp Ile Ile Ile His Ser Leu Lys Lys Cys Asp Ile Ser 
145                 150                 155                 160 


Leu Gln Phe Phe Leu Pro Phe Ser Leu Gly Lys Glu Asp Gly Ser Gly 
                165                 170                 175     


Asp Arg Gly Asp Gly Pro Phe Arg Leu Gly Gly His Gly Pro Ser Phe 
            180                 185                 190         


Pro Leu Lys Gly Ile Thr Glu Gln Gln Lys Glu Gly Leu Glu Ile Val 
        195                 200                 205             


Lys Met Val Met Ile Ser Leu Glu Gly Glu Asp Gly Leu Asp Glu Ile 
    210                 215                 220                 


Tyr Ser Phe Ser Glu Ser Leu Arg Lys Leu Cys Val Phe Lys Lys Ile 
225                 230                 235                 240 


Glu Arg His Ser Ile His Trp Pro Cys Arg Leu Thr Ile Gly Ser Asn 
                245                 250                 255     


Leu Ser Ile Arg Ile Ala Ala Tyr Lys Ser Ile Leu Gln Glu Arg Val 
            260                 265                 270         


Lys Lys Thr Trp Thr Val Val Asp Ala Lys Thr Leu Lys Lys Glu Asp 
        275                 280                 285             


Ile Gln Lys Glu Thr Val Tyr Cys Leu Asn Asp Asp Asp Glu Thr Glu 
    290                 295                 300                 


Val Leu Lys Glu Asp Ile Ile Gln Gly Phe Arg Tyr Gly Ser Asp Ile 
305                 310                 315                 320 


Val Pro Phe Ser Lys Val Asp Glu Glu Gln Met Lys Tyr Lys Ser Glu 
                325                 330                 335     


Gly Lys Cys Phe Ser Val Leu Gly Phe Cys Lys Ser Ser Gln Val Gln 
            340                 345                 350         


Arg Arg Phe Phe Met Gly Asn Gln Val Leu Lys Val Phe Ala Ala Arg 
        355                 360                 365             


Asp Asp Glu Ala Ala Ala Val Ala Leu Ser Ser Leu Ile His Ala Leu 
    370                 375                 380                 


Asp Asp Leu Asp Met Val Ala Ile Val Arg Tyr Ala Tyr Asp Lys Arg 
385                 390                 395                 400 


Ala Asn Pro Gln Val Gly Val Ala Phe Pro His Ile Lys His Asn Tyr 
                405                 410                 415     


Glu Cys Leu Val Tyr Val Gln Leu Pro Phe Met Glu Asp Leu Arg Gln 
            420                 425                 430         


Tyr Met Phe Ser Ser Leu Lys Asn Ser Lys Lys Tyr Ala Pro Thr Glu 
        435                 440                 445             


Ala Gln Leu Asn Ala Val Asp Ala Leu Ile Asp Ser Met Ser Leu Ala 
    450                 455                 460                 


Lys Lys Asp Glu Lys Thr Asp Thr Leu Glu Asp Leu Phe Pro Thr Thr 
465                 470                 475                 480 


Lys Ile Pro Asn Pro Arg Phe Gln Arg Leu Phe Gln Cys Leu Leu His 
                485                 490                 495     


Arg Ala Leu His Pro Arg Glu Pro Leu Pro Pro Ile Gln Gln His Ile 
            500                 505                 510         


Trp Asn Met Leu Asn Pro Pro Ala Glu Val Thr Thr Lys Ser Gln Ile 
        515                 520                 525             


Pro Leu Ser Lys Ile Lys Thr Leu Phe Pro Leu Ile Glu Ala Lys Lys 
    530                 535                 540                 


Lys Asp Gln Val Thr Ala Gln Glu Ile Phe Gln Asp Asn His Glu Asp 
545                 550                 555                 560 


Gly Pro Thr Ala Lys Lys Leu Lys Thr Glu Gln Gly Gly Ala His Phe 
                565                 570                 575     


Ser Val Ser Ser Leu Ala Glu Gly Ser Val Thr Ser Val Gly Ser Val 
            580                 585                 590         


Asn Pro Ala Glu Asn Phe Arg Val Leu Val Lys Gln Lys Lys Ala Ser 
        595                 600                 605             


Phe Glu Glu Ala Ser Asn Gln Leu Ile Asn His Ile Glu Gln Phe Leu 
    610                 615                 620                 


Asp Thr Asn Glu Thr Pro Tyr Phe Met Lys Ser Ile Asp Cys Ile Arg 
625                 630                 635                 640 


Ala Phe Arg Glu Glu Ala Ile Lys Phe Ser Glu Glu Gln Arg Phe Asn 
                645                 650                 655     


Asn Phe Leu Lys Ala Leu Gln Glu Lys Val Glu Ile Lys Gln Leu Asn 
            660                 665                 670         


His Phe Trp Glu Ile Val Val Gln Asp Gly Ile Thr Leu Ile Thr Lys 
        675                 680                 685             


Glu Glu Ala Ser Gly Ser Ser Val Thr Ala Glu Glu Ala Lys Lys Phe 
    690                 695                 700                 


Leu Ala Pro Lys Asp Lys Pro Ser Gly Asp Thr Ala Ala Val Phe Glu 
705                 710                 715                 720 


Glu Gly Gly Asp Val Asp Asp Leu Leu Asp Met Ile 
                725                 730         


<210>  112
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Ser Gly Trp Glu Ser Tyr Tyr Lys Thr Glu Gly Asp Glu Glu Ala 
1               5                   10                  15      


Glu Glu Glu Gln Glu Glu Asn Leu Glu Ala Ser Gly Asp Tyr Lys Tyr 
            20                  25                  30          


Ser Gly Arg Asp Ser Leu Ile Phe Leu Val Asp Ala Ser Lys Ala Met 
        35                  40                  45              


Phe Glu Ser Gln Ser Glu Asp Glu Leu Thr Pro Phe Asp Met Ser Ile 
    50                  55                  60                  


Gln Cys Ile Gln Ser Val Tyr Ile Ser Lys Ile Ile Ser Ser Asp Arg 
65                  70                  75                  80  


Asp Leu Leu Ala Val Val Phe Tyr Gly Thr Glu Lys Asp Lys Asn Ser 
                85                  90                  95      


Val Asn Phe Lys Asn Ile Tyr Val Leu Gln Glu Leu Asp Asn Pro Gly 
            100                 105                 110         


Ala Lys Arg Ile Leu Glu Leu Asp Gln Phe Lys Gly Gln Gln Gly Gln 
        115                 120                 125             


Lys Arg Phe Gln Asp Met Met Gly His Gly Ser Asp Tyr Ser Leu Ser 
    130                 135                 140                 


Glu Val Leu Trp Val Cys Ala Asn Leu Phe Ser Asp Val Gln Phe Lys 
145                 150                 155                 160 


Met Ser His Lys Arg Ile Met Leu Phe Thr Asn Glu Asp Asn Pro His 
                165                 170                 175     


Gly Asn Asp Ser Ala Lys Ala Ser Arg Ala Arg Thr Lys Ala Gly Asp 
            180                 185                 190         


Leu Arg Asp Thr Gly Ile Phe Leu Asp Leu Met His Leu Lys Lys Pro 
        195                 200                 205             


Gly Gly Phe Asp Ile Ser Leu Phe Tyr Arg Asp Ile Ile Ser Ile Ala 
    210                 215                 220                 


Glu Asp Glu Asp Leu Arg Val His Phe Glu Glu Ser Ser Lys Leu Glu 
225                 230                 235                 240 


Asp Leu Leu Arg Lys Val Arg Ala Lys Glu Thr Arg Lys Arg Ala Leu 
                245                 250                 255     


Ser Arg Leu Lys Leu Lys Leu Asn Lys Asp Ile Val Ile Ser Val Gly 
            260                 265                 270         


Ile Tyr Asn Leu Val Gln Lys Ala Leu Lys Pro Pro Pro Ile Lys Leu 
        275                 280                 285             


Tyr Arg Glu Thr Asn Glu Pro Val Lys Thr Lys Thr Arg Thr Phe Asn 
    290                 295                 300                 


Thr Ser Thr Gly Gly Leu Leu Leu Pro Ser Asp Thr Lys Arg Ser Gln 
305                 310                 315                 320 


Ile Tyr Gly Ser Arg Gln Ile Ile Leu Glu Lys Glu Glu Thr Glu Glu 
                325                 330                 335     


Leu Lys Arg Phe Asp Asp Pro Gly Leu Met Leu Met Gly Phe Lys Pro 
            340                 345                 350         


Leu Val Leu Leu Lys Lys His His Tyr Leu Arg Pro Ser Leu Phe Val 
        355                 360                 365             


Tyr Pro Glu Glu Ser Leu Val Ile Gly Ser Ser Thr Leu Phe Ser Ala 
    370                 375                 380                 


Leu Leu Ile Lys Cys Leu Glu Lys Glu Val Ala Ala Leu Cys Arg Tyr 
385                 390                 395                 400 


Thr Pro Arg Arg Asn Ile Pro Pro Tyr Phe Val Ala Leu Val Pro Gln 
                405                 410                 415     


Glu Glu Glu Leu Asp Asp Gln Lys Ile Gln Val Thr Pro Pro Gly Phe 
            420                 425                 430         


Gln Leu Val Phe Leu Pro Phe Ala Asp Asp Lys Arg Lys Met Pro Phe 
        435                 440                 445             


Thr Glu Lys Ile Met Ala Thr Pro Glu Gln Val Gly Lys Met Lys Ala 
    450                 455                 460                 


Ile Val Glu Lys Leu Arg Phe Thr Tyr Arg Ser Asp Ser Phe Glu Asn 
465                 470                 475                 480 


Pro Val Leu Gln Gln His Phe Arg Asn Leu Glu Ala Leu Ala Leu Asp 
                485                 490                 495     


Leu Met Glu Pro Glu Gln Ala Val Asp Leu Thr Leu Pro Lys Val Glu 
            500                 505                 510         


Ala Met Asn Lys Arg Leu Gly Ser Leu Val Asp Glu Phe Lys Glu Leu 
        515                 520                 525             


Val Tyr Pro Pro Asp Tyr Asn Pro Glu Gly Lys Val Thr Lys Arg Lys 
    530                 535                 540                 


His Asp Asn Glu Gly Ser Gly Ser Lys Arg Pro Lys Val Glu Tyr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Lys Thr His Ile Ser Lys Gly Thr Leu Gly Lys Phe 
                565                 570                 575     


Thr Val Pro Met Leu Lys Glu Ala Cys Arg Ala Tyr Gly Leu Lys Ser 
            580                 585                 590         


Gly Leu Lys Lys Gln Glu Leu Leu Glu Ala Leu Thr Lys His Phe Gln 
        595                 600                 605             


Asp 
    


<210>  113
<211>  1644
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Glu Glu Ser Lys Thr Leu Lys Ser Glu Asn His Glu Pro Lys Lys 
1               5                   10                  15      


Asn Val Ile Cys Glu Glu Ser Lys Ala Val Gln Val Ile Gly Asn Gln 
            20                  25                  30          


Thr Leu Lys Ala Arg Asn Asp Lys Ser Val Lys Glu Ile Glu Asn Ser 
        35                  40                  45              


Ser Pro Asn Arg Asn Ser Ser Lys Lys Asn Lys Gln Asn Asp Ile Cys 
    50                  55                  60                  


Ile Glu Lys Thr Glu Val Lys Ser Cys Lys Val Asn Ala Ala Asn Leu 
65                  70                  75                  80  


Pro Gly Pro Lys Asp Leu Gly Leu Val Leu Arg Asp Gln Ser His Cys 
                85                  90                  95      


Lys Ala Lys Lys Phe Pro Asn Ser Pro Val Lys Ala Glu Lys Ala Thr 
            100                 105                 110         


Ile Ser Gln Ala Lys Ser Glu Lys Ala Thr Ser Leu Gln Ala Lys Ala 
        115                 120                 125             


Glu Lys Ser Pro Lys Ser Pro Asn Ser Val Lys Ala Glu Lys Ala Ser 
    130                 135                 140                 


Ser Tyr Gln Met Lys Ser Glu Lys Val Pro Ser Ser Pro Ala Glu Ala 
145                 150                 155                 160 


Glu Lys Gly Pro Ser Leu Leu Leu Lys Asp Met Arg Gln Lys Thr Glu 
                165                 170                 175     


Leu Gln Gln Ile Gly Lys Lys Ile Pro Ser Ser Phe Thr Ser Val Asp 
            180                 185                 190         


Lys Val Asn Ile Glu Ala Val Gly Gly Glu Lys Cys Ala Leu Gln Asn 
        195                 200                 205             


Ser Pro Arg Ser Gln Lys Gln Gln Thr Cys Thr Asp Asn Thr Gly Asp 
    210                 215                 220                 


Ser Asp Asp Ser Ala Ser Gly Ile Glu Asp Val Ser Asp Asp Leu Ser 
225                 230                 235                 240 


Lys Met Lys Asn Asp Glu Ser Asn Lys Glu Asn Ser Ser Glu Met Asp 
                245                 250                 255     


Tyr Leu Glu Asn Ala Thr Val Ile Asp Glu Ser Ala Leu Thr Pro Glu 
            260                 265                 270         


Gln Arg Leu Gly Leu Lys Gln Ala Glu Glu Arg Leu Glu Arg Asp His 
        275                 280                 285             


Ile Phe Arg Leu Glu Lys Arg Ser Pro Glu Tyr Thr Asn Cys Arg Tyr 
    290                 295                 300                 


Leu Cys Lys Leu Cys Leu Ile His Ile Glu Asn Ile Gln Gly Ala His 
305                 310                 315                 320 


Lys His Ile Lys Glu Lys Arg His Lys Lys Asn Ile Leu Glu Lys Gln 
                325                 330                 335     


Glu Glu Ser Glu Leu Arg Ser Leu Pro Pro Pro Ser Pro Ala His Leu 
            340                 345                 350         


Ala Ala Leu Ser Val Ala Val Ile Glu Leu Ala Lys Glu His Gly Ile 
        355                 360                 365             


Thr Asp Asp Asp Leu Arg Val Arg Gln Glu Ile Val Glu Glu Met Ser 
    370                 375                 380                 


Lys Val Ile Thr Thr Phe Leu Pro Glu Cys Ser Leu Arg Leu Tyr Gly 
385                 390                 395                 400 


Ser Ser Leu Thr Arg Phe Ala Leu Lys Ser Ser Asp Val Asn Ile Asp 
                405                 410                 415     


Ile Lys Phe Pro Pro Lys Met Asn His Pro Asp Leu Leu Ile Lys Val 
            420                 425                 430         


Leu Gly Ile Leu Lys Lys Asn Val Leu Tyr Val Asp Val Glu Ser Asp 
        435                 440                 445             


Phe His Ala Lys Val Pro Val Val Val Cys Arg Asp Arg Lys Ser Gly 
    450                 455                 460                 


Leu Leu Cys Arg Val Ser Ala Gly Asn Asp Met Ala Cys Leu Thr Thr 
465                 470                 475                 480 


Asp Leu Leu Thr Ala Leu Gly Lys Ile Glu Pro Val Phe Ile Pro Leu 
                485                 490                 495     


Val Leu Ala Phe Arg Tyr Trp Ala Lys Leu Cys Tyr Ile Asp Ser Gln 
            500                 505                 510         


Thr Asp Gly Gly Ile Pro Ser Tyr Cys Phe Ala Leu Met Val Met Phe 
        515                 520                 525             


Phe Leu Gln Gln Arg Lys Pro Pro Leu Leu Pro Cys Leu Leu Gly Ser 
    530                 535                 540                 


Trp Ile Glu Gly Phe Asp Pro Lys Arg Met Asp Asp Phe Gln Leu Lys 
545                 550                 555                 560 


Gly Ile Val Glu Glu Lys Phe Val Lys Trp Glu Cys Asn Ser Ser Ser 
                565                 570                 575     


Ala Thr Glu Lys Asn Ser Ile Ala Glu Glu Asn Lys Ala Lys Ala Asp 
            580                 585                 590         


Gln Pro Lys Asp Asp Thr Lys Lys Thr Glu Thr Asp Asn Gln Ser Asn 
        595                 600                 605             


Ala Met Lys Glu Lys His Gly Lys Ser Pro Leu Ala Leu Glu Thr Pro 
    610                 615                 620                 


Asn Arg Val Ser Leu Gly Gln Leu Trp Leu Glu Leu Leu Lys Phe Tyr 
625                 630                 635                 640 


Thr Leu Asp Phe Ala Leu Glu Glu Tyr Val Ile Cys Val Arg Ile Gln 
                645                 650                 655     


Asp Ile Leu Thr Arg Glu Asn Lys Asn Trp Pro Lys Arg Arg Ile Ala 
            660                 665                 670         


Ile Glu Asp Pro Phe Ser Val Lys Arg Asn Val Ala Arg Ser Leu Asn 
        675                 680                 685             


Ser Gln Leu Val Tyr Glu Tyr Val Val Glu Arg Phe Arg Ala Ala Tyr 
    690                 695                 700                 


Arg Tyr Phe Ala Cys Pro Gln Thr Lys Gly Gly Asn Lys Ser Thr Val 
705                 710                 715                 720 


Asp Phe Lys Lys Arg Glu Lys Gly Lys Ile Ser Asn Lys Lys Pro Val 
                725                 730                 735     


Lys Ser Asn Asn Met Ala Thr Asn Gly Cys Ile Leu Leu Gly Glu Thr 
            740                 745                 750         


Thr Glu Lys Ile Asn Ala Glu Arg Glu Gln Pro Val Gln Cys Asp Glu 
        755                 760                 765             


Met Asp Cys Thr Ser Gln Arg Cys Ile Ile Asp Asn Asn Asn Leu Leu 
    770                 775                 780                 


Val Asn Glu Leu Asp Phe Ala Asp His Gly Gln Asp Ser Ser Ser Leu 
785                 790                 795                 800 


Ser Thr Ser Lys Ser Ser Glu Ile Glu Pro Lys Leu Asp Lys Lys Gln 
                805                 810                 815     


Asp Asp Leu Ala Pro Ser Glu Thr Cys Leu Lys Lys Glu Leu Ser Gln 
            820                 825                 830         


Cys Asn Cys Ile Asp Leu Ser Lys Ser Pro Asp Pro Asp Lys Ser Thr 
        835                 840                 845             


Gly Thr Asp Cys Arg Ser Asn Leu Glu Thr Glu Ser Ser His Gln Ser 
    850                 855                 860                 


Val Cys Thr Asp Thr Ser Ala Thr Ser Cys Asn Cys Lys Ala Thr Glu 
865                 870                 875                 880 


Asp Ala Ser Asp Leu Asn Asp Asp Asp Asn Leu Pro Thr Gln Glu Leu 
                885                 890                 895     


Tyr Tyr Val Phe Asp Lys Phe Ile Leu Thr Ser Gly Lys Pro Pro Thr 
            900                 905                 910         


Ile Val Cys Ser Ile Cys Lys Lys Asp Gly His Ser Lys Asn Asp Cys 
        915                 920                 925             


Pro Glu Asp Phe Arg Lys Ile Asp Leu Lys Pro Leu Pro Pro Met Thr 
    930                 935                 940                 


Asn Arg Phe Arg Glu Ile Leu Asp Leu Val Cys Lys Arg Cys Phe Asp 
945                 950                 955                 960 


Glu Leu Ser Pro Pro Cys Ser Glu Gln His Asn Arg Glu Gln Ile Leu 
                965                 970                 975     


Ile Gly Leu Glu Lys Phe Ile Gln Lys Glu Tyr Asp Glu Lys Ala Arg 
            980                 985                 990         


Leu Cys Leu Phe Gly Ser Ser Lys  Asn Gly Phe Gly Phe  Arg Asp Ser 
        995                 1000                 1005             


Asp Leu  Asp Ile Cys Met Thr  Leu Glu Gly His Glu  Asn Ala Glu 
    1010                 1015                 1020             


Lys Leu  Asn Cys Lys Glu Ile  Ile Glu Asn Leu Ala  Lys Ile Leu 
    1025                 1030                 1035             


Lys Arg  His Pro Gly Leu Arg  Asn Ile Leu Pro Ile  Thr Thr Ala 
    1040                 1045                 1050             


Lys Val  Pro Ile Val Lys Phe  Glu His Arg Arg Ser  Gly Leu Glu 
    1055                 1060                 1065             


Gly Asp  Ile Ser Leu Tyr Asn  Thr Leu Ala Gln His  Asn Thr Arg 
    1070                 1075                 1080             


Met Leu  Ala Thr Tyr Ala Ala  Ile Asp Pro Arg Val  Gln Tyr Leu 
    1085                 1090                 1095             


Gly Tyr  Thr Met Lys Val Phe  Ala Lys Arg Cys Asp  Ile Gly Asp 
    1100                 1105                 1110             


Ala Ser  Arg Gly Ser Leu Ser  Ser Tyr Ala Tyr Ile  Leu Met Val 
    1115                 1120                 1125             


Leu Tyr  Phe Leu Gln Gln Arg  Lys Pro Pro Val Ile  Pro Val Leu 
    1130                 1135                 1140             


Gln Glu  Ile Phe Asp Gly Lys  Gln Ile Pro Gln Arg  Met Val Asp 
    1145                 1150                 1155             


Gly Trp  Asn Ala Phe Phe Phe  Asp Lys Thr Glu Glu  Leu Lys Lys 
    1160                 1165                 1170             


Arg Leu  Pro Ser Leu Gly Lys  Asn Thr Glu Ser Leu  Gly Glu Leu 
    1175                 1180                 1185             


Trp Leu  Gly Leu Leu Arg Phe  Tyr Thr Glu Glu Phe  Asp Phe Lys 
    1190                 1195                 1200             


Glu Tyr  Val Ile Ser Ile Arg  Gln Lys Lys Leu Leu  Thr Thr Phe 
    1205                 1210                 1215             


Glu Lys  Gln Trp Thr Ser Lys  Cys Ile Ala Ile Glu  Asp Pro Phe 
    1220                 1225                 1230             


Asp Leu  Asn His Asn Leu Gly  Ala Gly Val Ser Arg  Lys Met Thr 
    1235                 1240                 1245             


Asn Phe  Ile Met Lys Ala Phe  Ile Asn Gly Arg Lys  Leu Phe Gly 
    1250                 1255                 1260             


Thr Pro  Phe Tyr Pro Leu Ile  Gly Arg Glu Ala Glu  Tyr Phe Phe 
    1265                 1270                 1275             


Asp Ser  Arg Val Leu Thr Asp  Gly Glu Leu Ala Pro  Asn Asp Arg 
    1280                 1285                 1290             


Cys Cys  Arg Val Cys Gly Lys  Ile Gly His Tyr Met  Lys Asp Cys 
    1295                 1300                 1305             


Pro Lys  Arg Lys Ser Leu Leu  Phe Arg Leu Lys Lys  Lys Asp Ser 
    1310                 1315                 1320             


Glu Glu  Glu Lys Glu Gly Asn  Glu Glu Glu Lys Asp  Ser Arg Asp 
    1325                 1330                 1335             


Val Leu  Asp Pro Arg Asp Leu  His Asp Thr Arg Asp  Phe Arg Asp 
    1340                 1345                 1350             


Pro Arg  Asp Leu Arg Cys Phe  Ile Cys Gly Asp Ala  Gly His Val 
    1355                 1360                 1365             


Arg Arg  Glu Cys Pro Glu Val  Lys Leu Ala Arg Gln  Arg Asn Ser 
    1370                 1375                 1380             


Ser Val  Ala Ala Ala Gln Leu  Val Arg Asn Leu Val  Asn Ala Gln 
    1385                 1390                 1395             


Gln Val  Ala Gly Ser Ala Gln  Gln Gln Gly Asp Gln  Ser Ile Arg 
    1400                 1405                 1410             


Thr Arg  Gln Ser Ser Glu Cys  Ser Glu Ser Pro Ser  Tyr Ser Pro 
    1415                 1420                 1425             


Gln Pro  Gln Pro Phe Pro Gln  Asn Ser Ser Gln Ser  Ala Ala Ile 
    1430                 1435                 1440             


Thr Gln  Pro Ser Ser Gln Pro  Gly Ser Gln Pro Lys  Leu Gly Pro 
    1445                 1450                 1455             


Pro Gln  Gln Gly Ala Gln Pro  Pro His Gln Val Gln  Met Pro Leu 
    1460                 1465                 1470             


Tyr Asn  Phe Pro Gln Ser Pro  Pro Ala Gln Tyr Ser  Pro Met His 
    1475                 1480                 1485             


Asn Met  Gly Leu Leu Pro Met  His Pro Leu Gln Ile  Pro Ala Pro 
    1490                 1495                 1500             


Ser Trp  Pro Ile His Gly Pro  Val Ile His Ser Ala  Pro Gly Ser 
    1505                 1510                 1515             


Ala Pro  Ser Asn Ile Gly Leu  Asn Asp Pro Ser Ile  Ile Phe Ala 
    1520                 1525                 1530             


Gln Pro  Ala Ala Arg Pro Val  Ala Ile Pro Asn Thr  Ser His Asp 
    1535                 1540                 1545             


Gly His  Trp Pro Arg Thr Val  Ala Pro Asn Ser Leu  Val Asn Ser 
    1550                 1555                 1560             


Gly Ala  Val Gly Asn Ser Glu  Pro Gly Phe Arg Gly  Leu Thr Pro 
    1565                 1570                 1575             


Pro Ile  Pro Trp Glu His Ala  Pro Arg Pro His Phe  Pro Leu Val 
    1580                 1585                 1590             


Pro Ala  Ser Trp Pro Tyr Gly  Leu His Gln Asn Phe  Met His Gln 
    1595                 1600                 1605             


Gly Asn  Ala Arg Phe Gln Pro  Asn Lys Pro Phe Tyr  Thr Gln Asp 
    1610                 1615                 1620             


Arg Cys  Ala Thr Arg Arg Cys  Arg Glu Arg Cys Pro  His Pro Pro 
    1625                 1630                 1635             


Arg Gly  Asn Val Ser Glu 
    1640                 


