SEQUENCE LISTING

<110>  Compugen Ltd

<120>  NEW CELL-PENETRATING PEPTIDES AND USES THEREOF  

<130>  

<160>  40


<210>  1
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 1

Lys Lys Thr Cys Arg Arg Ile Asn Tyr Cys Ala Leu Asn Lys 
1               5                   10                  


<210>  2
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 2

Lys Lys Thr Leu Lys Lys Leu Trp Lys Lys Lys Lys Arg Lys 
1               5                   10                  


<210>  3
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 3

Arg Arg Arg His Gln Arg Lys Tyr Arg Arg Tyr 
1               5                   10      


<210>  4
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 4

Phe Leu Arg Arg Arg Arg Arg Phe Thr Arg Gln Thr 
1               5                   10          


<210>  5
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 5

Lys Lys Leu Ala Leu Tyr Leu Leu Leu Ala Leu 
1               5                   10      


<210>  6
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 6

Lys Pro Ser Ala Arg Met Leu Leu Leu Lys Gly Phe Gly Lys 
1               5                   10                  


<210>  7
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 7

Cys Leu Lys Gly Phe Thr Leu Asn Pro Asp Lys Lys Thr Cys Arg Arg 
1               5                   10                  15      

Ile Asn Tyr Cys Ala Leu Asn Lys Pro Gly Cys Glu His Glu Cys Val 
            20                  25                  30          

Asn Met 
        


<210>  8
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 8

Lys Ser Ser Lys Tyr Lys Ala Tyr Lys Lys Lys Lys Thr Leu Lys Lys 
1               5                   10                  15      

Leu Trp Lys Lys Lys Lys Arg Lys Phe Thr Pro Gly Lys Tyr Phe Ser 
            20                  25                  30          

Lys Lys 
        


<210>  9
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 9

Ser Arg Arg Ser Lys Ser Arg Ser Arg Ser Arg Arg Arg His Gln Arg 
1               5                   10                  15      

Lys Tyr Arg Arg Tyr Ser Arg Ser Tyr Ser Arg Ser Arg Ser Arg 
            20                  25                  30      


<210>  10
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 10

Asp Cys His Asp Met Phe Glu His Gly Ser Phe Leu Arg Arg Arg Arg 
1               5                   10                  15      

Arg Phe Thr Arg Gln Thr Gly Ala Glu Gly Thr Arg Gly Pro Ala Lys 
            20                  25                  30          


<210>  11
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 11

Glu Ala Pro Glu Met Pro Ala Leu Tyr Glu Lys Lys Leu Ala Leu Tyr 
1               5                   10                  15      

Leu Leu Leu Ala Leu Ser Leu Ala Ser Val Ala Met Cys Arg Thr 
            20                  25                  30      


<210>  12
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 12

Met Cys Leu Ala Thr Cys Thr Arg Asp Gly Lys Pro Ser Ala Arg Met 
1               5                   10                  15      

Leu Leu Leu Lys Gly Phe Gly Lys Asp Gly Phe Arg Phe Phe Thr Asn 
            20                  25                  30          

Phe Glu 
        


<210>  13
<211>  956
<212>  PRT
<213>  Homo sapiens

<400> 13

Met Glu Lys Met Leu Ala Gly Cys Phe Leu Leu Ile Leu Gly Gln Ile 
1               5                   10                  15      

Val Leu Leu Pro Ala Glu Ala Arg Glu Arg Ser Arg Gly Arg Ser Ile 
            20                  25                  30          

Ser Arg Gly Arg His Ala Arg Thr His Pro Gln Thr Ala Leu Leu Glu 
        35                  40                  45              

Ser Ser Cys Glu Asn Lys Arg Ala Asp Leu Val Phe Ile Ile Asp Ser 
    50                  55                  60                  

Ser Arg Ser Val Asn Thr His Asp Tyr Ala Lys Val Lys Glu Phe Ile 
65                  70                  75                  80  


Val Asp Ile Leu Gln Phe Leu Asp Ile Gly Pro Asp Val Thr Arg Val 
                85                  90                  95      

Gly Leu Leu Gln Tyr Gly Ser Thr Val Lys Asn Glu Phe Ser Leu Lys 
            100                 105                 110         

Thr Phe Lys Arg Lys Ser Glu Val Glu Arg Ala Val Lys Arg Met Arg 
        115                 120                 125             

His Leu Ser Thr Gly Thr Met Thr Gly Leu Ala Ile Gln Tyr Ala Leu 
    130                 135                 140                 

Asn Ile Ala Phe Ser Glu Ala Glu Gly Ala Arg Pro Leu Arg Glu Asn 
145                 150                 155                 160 

Val Pro Arg Val Ile Met Ile Val Thr Asp Gly Arg Pro Gln Asp Ser 
                165                 170                 175     

Val Ala Glu Val Ala Ala Lys Ala Arg Asp Thr Gly Ile Leu Ile Phe 
            180                 185                 190         

Ala Ile Gly Val Gly Gln Val Asp Phe Asn Thr Leu Lys Ser Ile Gly 
        195                 200                 205             

Ser Glu Pro His Glu Asp His Val Phe Leu Val Ala Asn Phe Ser Gln 
    210                 215                 220                 

Ile Glu Thr Leu Thr Ser Val Phe Gln Lys Lys Leu Cys Thr Ala His 
225                 230                 235                 240 

Met Cys Ser Thr Leu Glu His Asn Cys Ala His Phe Cys Ile Asn Ile 
                245                 250                 255     

Pro Gly Ser Tyr Val Cys Arg Cys Lys Gln Gly Tyr Ile Leu Asn Ser 
            260                 265                 270         

Asp Gln Thr Thr Cys Arg Ile Gln Asp Leu Cys Ala Met Glu Asp His 
        275                 280                 285             

Asn Cys Glu Gln Leu Cys Val Asn Val Pro Gly Ser Phe Val Cys Gln 
    290                 295                 300                 

Cys Tyr Ser Gly Tyr Ala Leu Ala Glu Asp Gly Lys Arg Cys Val Ala 
305                 310                 315                 320 

Val Asp Tyr Cys Ala Ser Glu Asn His Gly Cys Glu His Glu Cys Val 
                325                 330                 335     

Asn Ala Asp Gly Ser Tyr Leu Cys Gln Cys His Glu Gly Phe Ala Leu 
            340                 345                 350         

Asn Pro Asp Glu Lys Thr Cys Thr Lys Ile Asp Tyr Cys Ala Ser Ser 
        355                 360                 365             

Asn His Gly Cys Gln His Glu Cys Val Asn Thr Asp Asp Ser Tyr Ser 
    370                 375                 380                 

Cys His Cys Leu Lys Gly Phe Thr Leu Asn Pro Asp Lys Lys Thr Cys 
385                 390                 395                 400 

Arg Arg Ile Asn Tyr Cys Ala Leu Asn Lys Pro Gly Cys Glu His Glu 
                405                 410                 415     

Cys Val Asn Met Glu Glu Ser Tyr Tyr Cys Arg Cys His Arg Gly Tyr 
            420                 425                 430         

Thr Leu Asp Pro Asn Gly Lys Thr Cys Ser Arg Val Asp His Cys Ala 
        435                 440                 445             

Gln Gln Asp His Gly Cys Glu Gln Leu Cys Leu Asn Thr Glu Asp Ser 
    450                 455                 460                 

Phe Val Cys Gln Cys Ser Glu Gly Phe Leu Ile Asn Glu Asp Leu Lys 
465                 470                 475                 480 

Thr Cys Ser Arg Val Asp Tyr Cys Leu Leu Ser Asp His Gly Cys Glu 
                485                 490                 495     

Tyr Ser Cys Val Asn Met Asp Arg Ser Phe Ala Cys Gln Cys Pro Glu 
            500                 505                 510         

Gly His Val Leu Arg Ser Asp Gly Lys Thr Cys Ala Lys Leu Asp Ser 
        515                 520                 525             

Cys Ala Leu Gly Asp His Gly Cys Glu His Ser Cys Val Ser Ser Glu 
    530                 535                 540                 

Asp Ser Phe Val Cys Gln Cys Phe Glu Gly Tyr Ile Leu Arg Glu Asp 
545                 550                 555                 560 

Gly Lys Thr Cys Arg Arg Lys Asp Val Cys Gln Ala Ile Asp His Gly 
                565                 570                 575     

Cys Glu His Ile Cys Val Asn Ser Asp Asp Ser Tyr Thr Cys Glu Cys 
            580                 585                 590         

Leu Glu Gly Phe Arg Leu Ala Glu Asp Gly Lys Arg Cys Arg Arg Lys 
        595                 600                 605             

Asp Val Cys Lys Ser Thr His His Gly Cys Glu His Ile Cys Val Asn 
    610                 615                 620                 

Asn Gly Asn Ser Tyr Ile Cys Lys Cys Ser Glu Gly Phe Val Leu Ala 
625                 630                 635                 640 

Glu Asp Gly Arg Arg Cys Lys Lys Cys Thr Glu Gly Pro Ile Asp Leu 
                645                 650                 655     

Val Phe Val Ile Asp Gly Ser Lys Ser Leu Gly Glu Glu Asn Phe Glu 
            660                 665                 670         

Val Val Lys Gln Phe Val Thr Gly Ile Ile Asp Ser Leu Thr Ile Ser 
        675                 680                 685             

Pro Lys Ala Ala Arg Val Gly Leu Leu Gln Tyr Ser Thr Gln Val His 
    690                 695                 700                 

Thr Glu Phe Thr Leu Arg Asn Phe Asn Ser Ala Lys Asp Met Lys Lys 
705                 710                 715                 720 

Ala Val Ala His Met Lys Tyr Met Gly Lys Gly Ser Met Thr Gly Leu 
                725                 730                 735     

Ala Leu Lys His Met Phe Glu Arg Ser Phe Thr Gln Gly Glu Gly Ala 
            740                 745                 750         

Arg Pro Leu Ser Thr Arg Val Pro Arg Ala Ala Ile Val Phe Thr Asp 
        755                 760                 765             

Gly Arg Ala Gln Asp Asp Val Ser Glu Trp Ala Ser Lys Ala Lys Ala 
    770                 775                 780                 

Asn Gly Ile Thr Met Tyr Ala Val Gly Val Gly Lys Ala Ile Glu Glu 
785                 790                 795                 800 

Glu Leu Gln Glu Ile Ala Ser Glu Pro Thr Asn Lys His Leu Phe Tyr 
                805                 810                 815     

Ala Glu Asp Phe Ser Thr Met Asp Glu Ile Ser Glu Lys Leu Lys Lys 
            820                 825                 830         

Gly Ile Cys Glu Ala Leu Glu Asp Ser Asp Gly Arg Gln Asp Ser Pro 
        835                 840                 845             

Ala Gly Glu Leu Pro Lys Thr Val Gln Gln Pro Thr Glu Ser Glu Pro 
    850                 855                 860                 

Val Thr Ile Asn Ile Gln Asp Leu Leu Ser Cys Ser Asn Phe Ala Val 
865                 870                 875                 880 

Gln His Arg Tyr Leu Phe Glu Glu Asp Asn Leu Leu Arg Ser Thr Gln 
                885                 890                 895     

Lys Leu Ser His Ser Thr Lys Pro Ser Gly Ser Pro Leu Glu Glu Lys 
            900                 905                 910         

His Asp Gln Cys Lys Cys Glu Asn Leu Ile Met Phe Gln Asn Leu Ala 
        915                 920                 925             

Asn Glu Glu Val Arg Lys Leu Thr Gln Arg Leu Glu Glu Met Thr Gln 
    930                 935                 940                 

Arg Met Glu Ala Leu Glu Asn Arg Leu Arg Tyr Arg 
945                 950                 955     


<210>  14
<211>  489
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 14

Met Ala Thr Lys Lys Met Arg Ile Ser Glu Lys Leu Trp Asp Ser Leu 
1               5                   10                  15      

Glu Lys Asp Glu Cys Asn Ile Asp Glu Val Val Gln Leu Met Ser Leu 
            20                  25                  30          

Asp Glu Glu Glu Leu Ile Thr Lys Phe Ala Gln Glu Val Ser Leu Arg 
        35                  40                  45              

Ile Arg Tyr Leu Asp Glu Lys Pro Asn Glu Ile Ser Phe Ile Ala Glu 
    50                  55                  60                  

Ala Thr Glu Asp Tyr Ser Glu Pro Glu Thr Glu Ser Ser Asp Glu Glu 
65                  70                  75                  80  

Thr Tyr Phe Gln Gln Ile Arg Met Glu Arg Gly Glu Ser Ser Glu Thr 
                85                  90                  95      

Lys Arg Glu Gln Gln Asp Leu Gly Ala Thr Arg Lys Arg Lys Ile Glu 
            100                 105                 110         

Glu Arg Asn Pro Phe Tyr Thr Pro Pro Val His Lys Gly Ile Pro Ser 
        115                 120                 125             

Ser Thr Gly Arg Gly Thr Glu Ile Ser Thr Leu Asn Leu Asp Cys Ile 
    130                 135                 140                 

Ser Ser Phe Glu Glu Arg Lys Val Met Ile Asp Lys Trp Phe Asn Glu 
145                 150                 155                 160 

Ile Ser Leu Ile Ile Gln Thr Asn Lys Glu Ser Phe Asp Thr Ser Leu 
                165                 170                 175     

Lys Val Leu Thr Leu Met Glu His Arg Thr Glu Gly Ile Ala Lys Ser 
            180                 185                 190         

Phe Ile Lys Gln Ala Thr Trp Asp Ile Leu Ile Thr Pro Glu Lys Ile 
        195                 200                 205             

Ile Glu Glu Val Leu Thr Gly Phe Tyr Thr Met Phe Ile Gly Leu Asp 
    210                 215                 220                 

Tyr Ala Leu Ser Ala Glu Lys Glu Glu Glu Lys Arg Ile Lys Lys Ala 
225                 230                 235                 240 

Glu Glu Leu Leu Ile Lys Ser Gln Leu Cys Asn Ile Cys Glu Leu Asp 
                245                 250                 255     

Asn Phe Thr Cys Phe Tyr Glu Lys Gln Ile Asn Gln Leu Lys Phe Glu 
            260                 265                 270         

Asp Phe Pro Lys Trp Ile Glu Leu Tyr Leu Gly Lys Ile Pro Ile Ile 
        275                 280                 285             

Gly Lys Gln Ser Lys Glu Arg Trp Asp Asn Glu Lys Ser Phe Thr Thr 
    290                 295                 300                 

Lys Tyr Ser Leu Ala Phe Ala Lys Arg Ile Ile Gln Glu Glu Ile Ala 
305                 310                 315                 320 

Lys Tyr Cys Asp Phe Gln Arg Thr Ser Lys Lys Leu Lys Asn Phe Ser 
                325                 330                 335     

Lys Lys Cys Cys Ser Lys Asn Ser Leu Asp Pro Leu Val Ser Phe Gly 
            340                 345                 350         

Cys Arg Asp Thr Lys Lys Lys Asp Phe Lys Lys Ser Ser Lys Tyr Lys 
        355                 360                 365             

Ala Tyr Lys Lys Lys Lys Thr Leu Lys Lys Leu Trp Lys Lys Lys Lys 
    370                 375                 380                 

Arg Lys Phe Thr Pro Gly Lys Tyr Phe Ser Lys Lys Lys Pro Glu Lys 
385                 390                 395                 400 

Phe Cys Pro Gln Gly Arg Lys Lys Cys Arg Cys Trp Ile Cys Thr Glu 
                405                 410                 415     

Glu Gly His Tyr Ala Asn Glu Cys Pro Asn Arg Lys Ser His Gln Glu 
            420                 425                 430         

Lys Val Lys Ile Leu Ile His Gly Met Asn Glu Gly Tyr Tyr Pro Leu 
        435                 440                 445             

Glu Asp Ala Tyr Thr Gly Asn Leu Glu Val Phe Ser Met Glu Ile Ile 
    450                 455                 460                 

Glu Glu Thr Thr Ser Glu Glu Glu Ser Thr Thr Asp Ser Asp Ser Ser 
465                 470                 475                 480 

Ser Ser Asp Asp Glu Gln Leu Ser Phe 
                485                 


<210>  15
<211>  290
<212>  PRT
<213>  Homo sapiens

<400> 15

Met Ser Asn Tyr Val Asn Asp Met Trp Pro Gly Ser Pro Gln Glu Lys 
1               5                   10                  15      

Asp Ser Pro Ser Thr Ser Arg Ser Gly Gly Ser Ser Arg Leu Ser Ser 
            20                  25                  30          

Arg Ser Arg Ser Arg Ser Phe Ser Arg Ser Ser Arg Ser His Ser Arg 
        35                  40                  45              

Val Ser Ser Arg Phe Ser Ser Arg Ser Arg Arg Ser Lys Ser Arg Ser 
    50                  55                  60                  

Arg Ser Arg Arg Arg His Gln Arg Lys Tyr Arg Arg Tyr Ser Arg Ser 
65                  70                  75                  80  

Tyr Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Arg Tyr Arg Glu Arg 
                85                  90                  95      

Arg Tyr Gly Phe Thr Arg Arg Tyr Tyr Arg Ser Pro Ser Arg Tyr Arg 
            100                 105                 110         

Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Gly Arg Ser Tyr Cys Gly 
        115                 120                 125             

Arg Ala Tyr Ala Ile Ala Arg Gly Gln Arg Tyr Tyr Gly Phe Gly Arg 
    130                 135                 140                 

Thr Val Tyr Pro Glu Glu His Ser Arg Trp Arg Asp Arg Ser Arg Thr 
145                 150                 155                 160 

Arg Ser Arg Ser Arg Thr Pro Phe Arg Leu Ser Glu Lys Asp Arg Met 
                165                 170                 175     

Glu Leu Leu Glu Ile Ala Lys Thr Asn Ala Ala Lys Ala Leu Gly Thr 
            180                 185                 190         

Thr Asn Ile Asp Leu Pro Ala Ser Leu Arg Thr Val Pro Ser Ala Lys 
        195                 200                 205             

Glu Thr Ser Arg Gly Ile Gly Val Ser Ser Asn Gly Ala Lys Pro Glu 
    210                 215                 220                 

Leu Ser Glu Lys Val Thr Glu Asp Gly Thr Arg Asn Pro Asn Glu Lys 
225                 230                 235                 240 

Pro Thr Gln Gln Arg Ser Ile Ala Phe Ser Ser Asn Asn Ser Val Ala 
                245                 250                 255     

Lys Pro Ile Gln Lys Ser Ala Lys Ala Ala Thr Glu Glu Ala Ser Ser 
            260                 265                 270         

Arg Ser Pro Lys Ile Asp Gln Lys Lys Ser Pro Tyr Gly Leu Trp Ile 
        275                 280                 285             

Pro Ile 
    290 


<210>  16
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 16

Met Gln Gln Gln Pro Leu Pro Gly Pro Gly Ala Pro Thr Thr Glu Pro 
1               5                   10                  15      

Thr Lys Pro Pro Tyr Ser Tyr Ile Ala Leu Ile Ala Met Ala Ile Gln 
            20                  25                  30          

Ser Ser Pro Gly Gln Arg Ala Thr Leu Ser Gly Ile Tyr Arg Tyr Ile 
        35                  40                  45              

Met Gly Arg Phe Ala Phe Tyr Arg His Asn Arg Pro Gly Trp Gln Asn 
    50                  55                  60                  

Ser Ile Arg His Asn Leu Ser Leu Asn Glu Cys Phe Val Lys Val Pro 
65                  70                  75                  80  

Arg Asp Asp Arg Lys Pro Gly Lys Gly Ser Tyr Trp Thr Leu Asp Pro 
                85                  90                  95      

Asp Cys His Asp Met Phe Glu His Gly Ser Phe Leu Arg Arg Arg Arg 
            100                 105                 110         

Arg Phe Thr Arg Gln Thr Gly Ala Glu Gly Thr Arg Gly Pro Ala Lys 
        115                 120                 125             

Ala Arg Arg Gly Pro Leu Arg Ala Thr Ser Gln Asp Pro Gly Val Pro 
    130                 135                 140                 

Asn Ala Thr Thr Gly Arg Gln Cys Ser Phe Pro Pro Glu Leu Pro Asp 
145                 150                 155                 160 

Pro Lys Gly Leu Ser Phe Gly Gly Leu Val Gly Ala Met Pro Ala Ser 
                165                 170                 175     

Met Cys Pro Ala Thr Thr Asp Gly Arg Pro Arg Pro Pro Met Glu Pro 
            180                 185                 190         

Lys Glu Ile Ser Thr Pro Lys Pro Ala Cys Pro Gly Glu Leu Pro Val 
        195                 200                 205             

Ala Thr Ser Ser Ser Ser Cys Pro Ala Phe Gly Phe Pro Ala Gly Phe 
    210                 215                 220                 

Ser Glu Ala Glu Ser Phe Asn Lys Ala Pro Thr Pro Val Leu Ser Pro 
225                 230                 235                 240 

Glu Ser Gly Ile Gly Ser Ser Tyr Gln Cys Arg Leu Gln Ala Leu Asn 
                245                 250                 255     

Phe Cys Met Gly Ala Asp Pro Gly Leu Glu His Leu Leu Ala Ser Ala 
            260                 265                 270         

Ala Pro Ser Pro Ala Pro Pro Thr Pro Pro Gly Ser Leu Arg Ala Pro 
        275                 280                 285             

Leu Pro Leu Pro Thr Asp His Lys Glu Pro Trp Val Ala Gly Gly Phe 
    290                 295                 300                 

Pro Val Gln Gly Gly Ser Gly Tyr Pro Leu Gly Leu Thr Pro Cys Leu 
305                 310                 315                 320 

Tyr Arg Thr Pro Gly Met Phe Phe Phe Glu 
                325                 330 


<210>  17
<211>  3411
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 17

Met Ser Gly Arg Lys Ala Gln Gly Lys Thr Leu Gly Val Asn Met Val 
1               5                   10                  15      

Arg Arg Gly Val Arg Ser Leu Ser Asn Lys Ile Lys Gln Lys Thr Lys 
            20                  25                  30          

Gln Ile Gly Asn Arg Pro Gly Pro Ser Arg Gly Val Gln Gly Phe Ile 
        35                  40                  45              

Phe Phe Phe Leu Phe Asn Ile Leu Thr Gly Lys Lys Ile Thr Ala Gln 
    50                  55                  60                  

Leu Lys Arg Leu Trp Lys Met Leu Asp Pro Arg Gln Gly Leu Ala Ala 
65                  70                  75                  80  

Leu Arg Lys Val Lys Arg Val Val Ala Gly Leu Met Arg Gly Leu Ser 
                85                  90                  95      

Ser Arg Lys Arg Arg Ser His Asp Val Leu Thr Val Gln Phe Leu Ile 
            100                 105                 110         

Leu Gly Met Leu Leu Met Thr Gly Gly Val Thr Leu Met Arg Lys Asn 
        115                 120                 125             

Arg Trp Leu Leu Leu Asn Val Thr Ser Glu Asp Leu Gly Lys Thr Phe 
    130                 135                 140                 

Ser Ile Gly Thr Gly Asn Cys Thr Thr Asn Ile Leu Glu Ala Lys Tyr 
145                 150                 155                 160 

Trp Cys Pro Asp Ser Met Glu Tyr Asn Cys Pro Asn Leu Ser Pro Arg 
                165                 170                 175     

Glu Glu Pro Asp Asp Ile Asp Cys Trp Cys Tyr Gly Val Glu Asn Val 
            180                 185                 190         

Arg Val Thr Tyr Gly Lys Cys Asp Ser Ala Gly Arg Ser Arg Arg Ser 
        195                 200                 205             

Arg Arg Ala Ile Asp Leu Pro Thr His Glu Asn His Gly Leu Lys Thr 
    210                 215                 220                 

Arg Gln Glu Lys Trp Met Thr Gly Arg Met Gly Glu Arg Gln Leu Gln 
225                 230                 235                 240 

Lys Ile Glu Arg Trp Phe Val Arg Asn Pro Phe Phe Ala Val Thr Ala 
                245                 250                 255     

Leu Thr Ile Ala Tyr Leu Val Gly Ser Asn Met Thr Gln Arg Val Val 
            260                 265                 270         

Ile Ala Leu Leu Val Leu Ala Val Gly Pro Ala Tyr Ser Ala His Cys 
        275                 280                 285             

Ile Gly Val Ala Asp Arg Asp Phe Ile Glu Gly Val His Gly Gly Thr 
    290                 295                 300                 

Trp Val Ser Ala Thr Leu Glu Gln Asp Lys Cys Val Thr Val Met Ala 
305                 310                 315                 320 

Pro Asp Lys Pro Ser Leu Asp Ile Ser Leu Glu Thr Val Ala Ile Asp 
                325                 330                 335     

Gly Pro Val Glu Ala Arg Lys Val Cys Tyr Asn Ala Val Leu Thr His 
            340                 345                 350         

Val Lys Ile Asp Asp Lys Cys Pro Ser Thr Gly Glu Ala His Leu Ala 
        355                 360                 365             

Glu Glu Asn Glu Gly Asp Asn Ala Cys Lys Arg Thr Tyr Ser Asp Arg 
    370                 375                 380                 

Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Ile Val Ala 
385                 390                 395                 400 

Cys Ala Lys Phe Thr Cys Ala Lys Ser Met Ser Leu Phe Glu Val Asp 
                405                 410                 415     

Gln Thr Lys Ile Gln Tyr Val Ile Lys Ala Gln Leu His Val Gly Ala 
            420                 425                 430         

Lys Gln Glu Asp Trp Lys Thr Asp Ile Lys Thr Leu Lys Phe Asp Val 
        435                 440                 445             

Leu Ser Gly Ser Gln Glu Ala Glu Phe Thr Gly Tyr Gly Lys Val Thr 
    450                 455                 460                 

Leu Glu Cys Gln Val Gln Thr Ala Val Asp Phe Gly Asn Ser Tyr Ile 
465                 470                 475                 480 

Ala Glu Met Glu Lys Glu Ser Trp Ile Val Asp Arg Gln Trp Ala Gln 
                485                 490                 495     

Asp Leu Thr Leu Pro Trp Gln Ser Gly Ser Gly Gly Val Trp Arg Glu 
            500                 505                 510         

Met His His Leu Val Glu Phe Glu Pro Pro His Ala Ala Thr Ile Arg 
        515                 520                 525             

Val Leu Ala Leu Gly Asp Gln Glu Gly Ser Leu Lys Thr Ala Leu Thr 
    530                 535                 540                 

Gly Ala Met Arg Val Thr Lys Asp Thr Asn Asp Asn Asn Leu Tyr Lys 
545                 550                 555                 560 

Leu His Gly Gly His Val Ser Cys Arg Val Lys Leu Ser Ala Leu Thr 
                565                 570                 575     

Leu Lys Gly Thr Ser Tyr Lys Met Cys Thr Asp Lys Met Ser Phe Val 
            580                 585                 590         

Lys Asn Pro Thr Asp Thr Gly His Gly Thr Val Val Met Gln Val Lys 
        595                 600                 605             

Val Pro Lys Gly Ala Pro Cys Lys Ile Pro Val Ile Val Ala Asp Asp 
    610                 615                 620                 

Leu Thr Ala Ala Ile Asn Lys Gly Ile Leu Val Thr Val Asn Pro Ile 
625                 630                 635                 640 


Ala Ser Thr Asn Asp Asp Glu Val Leu Ile Glu Val Asn Pro Pro Phe 
                645                 650                 655     

Gly Asp Ser Tyr Ile Ile Ile Gly Thr Gly Asp Ser Arg Leu Thr Tyr 
            660                 665                 670         

Gln Trp His Lys Glu Gly Ser Ser Ile Gly Lys Leu Phe Thr Gln Thr 
        675                 680                 685             

Met Lys Gly Ala Glu Arg Leu Ala Val Met Gly Asp Ala Ala Trp Asp 
    690                 695                 700                 

Phe Ser Ser Ala Gly Gly Phe Phe Thr Ser Val Gly Lys Gly Ile His 
705                 710                 715                 720 

Thr Val Phe Gly Ser Ala Phe Gln Gly Leu Phe Gly Gly Leu Asn Trp 
                725                 730                 735     

Ile Thr Lys Val Ile Met Gly Ala Val Leu Ile Trp Val Gly Phe Asn 
            740                 745                 750         

Thr Arg Asn Met Thr Met Ser Met Ser Met Ile Leu Val Gly Val Ile 
        755                 760                 765             

Met Met Phe Leu Ser Leu Gly Val Gly Ala Asp Gln Gly Cys Ala Ile 
    770                 775                 780                 

Asn Phe Gly Lys Arg Glu Leu Lys Cys Gly Asp Gly Ile Phe Ile Phe 
785                 790                 795                 800 

Arg Asp Ser Asp Asp Trp Leu Asn Lys Tyr Ser Tyr Tyr Pro Glu Asp 
                805                 810                 815     

Pro Val Lys Leu Ala Ser Ile Val Lys Ala Ser Phe Glu Glu Gly Lys 
            820                 825                 830         

Cys Gly Leu Asn Ser Val Asp Ser Leu Glu His Glu Met Trp Arg Ser 
        835                 840                 845             

Arg Ala Asp Glu Ile Asn Ala Ile Leu Glu Glu Asn Glu Val Asp Ile 
    850                 855                 860                 

Ser Val Val Val Gln Asp Pro Lys Asn Val Tyr Gln Arg Gly Thr His 
865                 870                 875                 880 

Pro Phe Ser Arg Ile Arg Asp Gly Leu Gln Tyr Gly Trp Lys Thr Trp 
                885                 890                 895     

Gly Lys Asn Leu Val Phe Ser Pro Gly Arg Lys Asn Gly Ser Phe Ile 
            900                 905                 910         

Ile Asp Gly Lys Ser Arg Lys Glu Cys Pro Phe Ser Asn Arg Val Trp 
        915                 920                 925             

Asn Ser Phe Gln Ile Glu Glu Phe Gly Thr Gly Val Phe Thr Thr Arg 
    930                 935                 940                 

Val Tyr Met Asp Ala Val Phe Glu Tyr Thr Ile Asp Cys Asp Gly Ser 
945                 950                 955                 960 


Ile Leu Gly Ala Ala Val Asn Gly Lys Lys Ser Ala His Gly Ser Pro 
                965                 970                 975     

Thr Phe Trp Met Gly Ser His Glu Val Asn Gly Thr Trp Met Ile His 
            980                 985                 990         

Thr Leu Glu Ala Leu Asp Tyr Lys  Glu Cys Glu Trp Pro  Leu Thr His 
        995                 1000                 1005             

Thr Ile  Gly Thr Ser Val Glu  Glu Ser Glu Met Phe  Met Pro Arg 
    1010                 1015                 1020             

Ser Ile  Gly Gly Pro Val Ser  Ser His Asn His Ile  Pro Gly Tyr 
    1025                 1030                 1035             

Lys Val  Gln Thr Asn Gly Pro  Trp Met Gln Val Pro  Leu Glu Val 
    1040                 1045                 1050             

Lys Arg  Glu Ala Cys Pro Gly  Thr Ser Val Ile Ile  Asp Gly Asn 
    1055                 1060                 1065             

Cys Asp  Gly Arg Gly Lys Ser  Thr Arg Ser Thr Thr  Asp Ser Gly 
    1070                 1075                 1080             

Lys Ile  Ile Pro Glu Trp Cys  Cys Arg Ser Cys Thr  Met Pro Pro 
    1085                 1090                 1095             

Val Ser  Phe His Gly Ser Asp  Gly Cys Trp Tyr Pro  Met Glu Ile 
    1100                 1105                 1110             

Arg Pro  Met Lys Thr His Glu  Ser His Leu Val Arg  Ser Trp Val 
    1115                 1120                 1125             

Thr Ala  Gly Glu Ile His Ala  Val Pro Phe Gly Leu  Val Ser Met 
    1130                 1135                 1140             

Met Ile  Ala Met Glu Val Val  Leu Arg Lys Arg Gln  Gly Pro Lys 
    1145                 1150                 1155             

Gln Val  Leu Val Gly Gly Val  Val Leu Leu Gly Ala  Met Leu Val 
    1160                 1165                 1170             

Gly Gln  Val Thr Leu Leu Asp  Leu Leu Glu Leu Thr  Val Ala Val 
    1175                 1180                 1185             

Gly Leu  His Phe His Glu Met  Asn Asn Gly Gly Asp  Ala Met Tyr 
    1190                 1195                 1200             

Met Ala  Leu Ile Ala Ala Phe  Ser Val Arg Pro Gly  Leu Leu Ile 
    1205                 1210                 1215             

Gly Phe  Gly Leu Arg Thr Leu  Trp Ser Pro Arg Glu  Arg Leu Val 
    1220                 1225                 1230             

Leu Ala  Leu Gly Ala Ala Met  Val Glu Ile Ala Leu  Gly Gly Met 
    1235                 1240                 1245             

Met Gly  Gly Leu Trp Lys Tyr  Leu Asn Ala Val Ser  Leu Cys Ile 
    1250                 1255                 1260             

Leu Thr  Ile Asn Ala Val Ala  Ser Arg Lys Ala Ser  Asn Ala Ile 
    1265                 1270                 1275             

Leu Pro  Leu Met Ala Leu Leu  Thr Pro Val Thr Met  Ala Glu Val 
    1280                 1285                 1290             

Arg Leu  Ala Thr Met Leu Phe  Cys Thr Val Val Ile  Ile Gly Val 
    1295                 1300                 1305             

Leu His  Gln Asn Ser Lys Asp  Thr Ser Met Gln Lys  Thr Ile Pro 
    1310                 1315                 1320             

Leu Val  Ala Leu Thr Leu Thr  Ser Tyr Leu Gly Leu  Thr Gln Pro 
    1325                 1330                 1335             

Phe Leu  Gly Leu Cys Ala Phe  Leu Ala Thr Arg Ile  Phe Gly Arg 
    1340                 1345                 1350             

Arg Ser  Ile Pro Val Asn Glu  Ala Leu Ala Ala Thr  Gly Leu Val 
    1355                 1360                 1365             

Gly Val  Leu Ala Gly Leu Ala  Phe Gln Glu Met Glu  Asn Phe Leu 
    1370                 1375                 1380             

Gly Pro  Ile Ala Val Gly Gly  Ile Leu Met Met Leu  Val Ser Val 
    1385                 1390                 1395             

Ala Gly  Arg Val Asp Gly Leu  Glu Leu Lys Lys Leu  Gly Glu Val 
    1400                 1405                 1410             

Ser Trp  Glu Glu Glu Ala Glu  Ile Ser Gly Ser Ser  Ala Arg Tyr 
    1415                 1420                 1425             

Asp Val  Ala Leu Ser Glu Gln  Gly Glu Phe Lys Leu  Leu Ser Glu 
    1430                 1435                 1440             

Glu Lys  Val Pro Trp Asp Gln  Val Val Met Thr Ser  Leu Ala Leu 
    1445                 1450                 1455             

Val Gly  Ala Ala Ile His Pro  Phe Ala Leu Leu Leu  Val Leu Ala 
    1460                 1465                 1470             

Gly Trp  Leu Phe His Val Arg  Arg Ala Arg Arg Ser  Gly Asp Val 
    1475                 1480                 1485             

Leu Trp  Asp Ile Pro Thr Pro  Lys Ile Ile Glu Glu  Cys Glu His 
    1490                 1495                 1500             

Leu Glu  Asp Gly Ile Tyr Gly  Ile Phe Gln Ser Thr  Phe Leu Gly 
    1505                 1510                 1515             

Ala Ser  Gln Arg Gly Val Gly  Val Ala Gln Gly Gly  Val Phe His 
    1520                 1525                 1530             

Thr Met  Trp His Val Thr Arg  Gly Ala Phe Leu Val  Trp Asn Gly 
    1535                 1540                 1545             

Lys Lys  Leu Ile Pro Ser Trp  Ala Ser Val Lys Glu  Asp Leu Val 
    1550                 1555                 1560             

Ala Tyr  Gly Gly Ser Trp Lys  Leu Glu Gly Arg Trp  Asp Gly Glu 
    1565                 1570                 1575             

Glu Glu  Val Gln Leu Ile Ala  Ala Ala Pro Gly Lys  Asn Val Val 
    1580                 1585                 1590             

Asn Val  Gln Thr Lys Pro Ser  Leu Phe Lys Val Arg  Asn Gly Gly 
    1595                 1600                 1605             

Glu Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ser Gly  Thr Ser Gly 
    1610                 1615                 1620             

Ser Pro  Ile Val Asn Arg Asn  Gly Glu Val Ile Gly  Leu Tyr Gly 
    1625                 1630                 1635             

Asn Gly  Ile Leu Val Gly Asp  Asn Ser Phe Val Ser  Ala Ile Ser 
    1640                 1645                 1650             

Gln Thr  Glu Val Lys Glu Glu  Gly Lys Glu Glu Leu  Gln Glu Ile 
    1655                 1660                 1665             

Pro Thr  Met Leu Lys Lys Gly  Lys Thr Thr Ile Leu  Asp Phe His 
    1670                 1675                 1680             

Pro Gly  Ala Gly Lys Thr Arg  Arg Phe Leu Pro Gln  Ile Leu Ala 
    1685                 1690                 1695             

Glu Cys  Ala Arg Arg Arg Leu  Arg Thr Leu Val Leu  Ala Pro Thr 
    1700                 1705                 1710             

Arg Val  Val Leu Ser Glu Met  Lys Glu Ala Phe His  Gly Leu Asp 
    1715                 1720                 1725             

Val Lys  Phe His Thr Gln Ala  Phe Ser Ala His Gly  Ser Gly Arg 
    1730                 1735                 1740             

Glu Val  Ile Asp Val Met Cys  His Ala Thr Leu Thr  Tyr Arg Met 
    1745                 1750                 1755             

Leu Glu  Pro Thr Arg Ile Val  Asn Trp Glu Val Ile  Ile Met Asp 
    1760                 1765                 1770             

Glu Ala  His Phe Leu Asp Pro  Ala Ser Ile Ala Ala  Arg Gly Trp 
    1775                 1780                 1785             

Ala Ala  His Arg Ala Arg Ala  Asn Glu Ser Ala Thr  Ile Leu Met 
    1790                 1795                 1800             

Thr Ala  Thr Pro Pro Gly Thr  Ser Asp Glu Phe Pro  His Ser Asn 
    1805                 1810                 1815             

Gly Glu  Ile Glu Asp Val Gln  Thr Asp Ile Pro Ser  Glu Pro Trp 
    1820                 1825                 1830             

Asn Thr  Gly His Asp Trp Ile  Leu Ala Asp Lys Arg  Pro Thr Ala 
    1835                 1840                 1845             

Trp Phe  Leu Pro Ser Ile Arg  Ala Ala Asn Val Met  Ala Ala Ser 
    1850                 1855                 1860             

Leu Arg  Lys Ala Gly Lys Ser  Val Val Val Leu Asn  Arg Lys Thr 
    1865                 1870                 1875             

Phe Glu  Arg Glu Tyr Pro Thr  Ile Lys Gln Lys Lys  Pro Asp Phe 
    1880                 1885                 1890             

Ile Leu  Ala Thr Asp Ile Ala  Glu Met Gly Ala Asn  Leu Cys Val 
    1895                 1900                 1905             

Glu Arg  Val Leu Asp Cys Arg  Thr Ala Phe Lys Pro  Val Leu Val 
    1910                 1915                 1920             

Asp Glu  Gly Arg Lys Val Ala  Ile Lys Gly Pro Leu  Arg Ile Ser 
    1925                 1930                 1935             

Ala Ser  Ser Ala Ala Gln Arg  Arg Gly Arg Ile Gly  Arg Asn Pro 
    1940                 1945                 1950             

Asn Arg  Asp Gly Asp Ser Tyr  Tyr Tyr Ser Glu Pro  Thr Ser Glu 
    1955                 1960                 1965             

Asp Asn  Ala His His Val Cys  Trp Leu Glu Ala Ser  Met Leu Leu 
    1970                 1975                 1980             

Asp Asn  Met Glu Val Arg Gly  Gly Met Val Ala Pro  Leu Tyr Gly 
    1985                 1990                 1995             

Val Glu  Gly Ile Lys Thr Pro  Val Ser Pro Gly Glu  Met Arg Leu 
    2000                 2005                 2010             

Arg Asp  Asp Gln Arg Lys Val  Phe Arg Glu Leu Val  Arg Asn Cys 
    2015                 2020                 2025             

Asp Leu  Pro Val Trp Leu Ser  Trp Gln Val Ala Lys  Ala Gly Leu 
    2030                 2035                 2040             

Lys Thr  Asn Asp Arg Lys Trp  Cys Phe Glu Gly Pro  Glu Glu His 
    2045                 2050                 2055             

Glu Ile  Leu Asn Asp Ser Gly  Glu Thr Val Lys Cys  Arg Ala Pro 
    2060                 2065                 2070             

Gly Gly  Ala Lys Lys Pro Leu  Arg Pro Arg Trp Cys  Asp Glu Arg 
    2075                 2080                 2085             

Val Ser  Ser Asp Gln Ser Ala  Leu Ser Glu Phe Ile  Lys Phe Ala 
    2090                 2095                 2100             

Glu Gly  Arg Arg Gly Ala Ala  Asp Val Leu Val Val  Leu Ser Glu 
    2105                 2110                 2115             

Leu Pro  Asp Phe Leu Ala Lys  Lys Gly Gly Glu Ala  Met Asp Thr 
    2120                 2125                 2130             

Ile Ser  Val Phe Leu His Ser  Glu Glu Gly Ser Arg  Ala Tyr Arg 
    2135                 2140                 2145             

Asn Ala  Leu Ser Met Met Pro  Glu Ala Met Thr Ile  Val Met Leu 
    2150                 2155                 2160             

Phe Leu  Leu Ala Gly Leu Leu  Thr Ser Gly Met Val  Ile Phe Phe 
    2165                 2170                 2175             

Met Ser  Pro Lys Gly Ile Ser  Arg Met Ser Met Ala  Lys Gly Thr 
    2180                 2185                 2190             

Met Ala  Gly Cys Gly Tyr Leu  Met Phe Leu Gly Gly  Val Glu Pro 
    2195                 2200                 2205             

Thr His  Ile Ser Tyr Ile Met  Leu Ile Phe Phe Val  Leu Met Val 
    2210                 2215                 2220             

Val Val  Ile Pro Glu Pro Gly  Gln Gln Arg Ser Ile  Gln Asp Asn 
    2225                 2230                 2235             

Gln Val  Ala Phe Leu Ile Ile  Gly Ile Leu Thr Leu  Val Ser Val 
    2240                 2245                 2250             

Val Ala  Ala Asn Glu Leu Gly  Met Leu Glu Lys Thr  Lys Glu Asp 
    2255                 2260                 2265             

Leu Phe  Gly Lys Lys Asn Leu  Ile Pro Ser Gly Ala  Ser Pro Trp 
    2270                 2275                 2280             

Ser Trp  Pro Asp Leu Asp Leu  Lys Pro Gly Ala Ala  Trp Thr Val 
    2285                 2290                 2295             

Tyr Val  Gly Ile Val Thr Met  Leu Ser Pro Met Leu  His His Trp 
    2300                 2305                 2310             


Ile Lys  Val Glu Tyr Gly Asn  Leu Ser Leu Ser Gly  Ile Ala Gln 
    2315                 2320                 2325             

Ser Ala  Ser Val Leu Ser Phe  Met Asp Lys Gly Ile  Pro Phe Met 
    2330                 2335                 2340             

Lys Met  Asn Ile Ser Val Ile  Met Leu Leu Val Ser  Gly Trp Asn 
    2345                 2350                 2355             

Ser Ile  Thr Val Met Pro Leu  Leu Cys Gly Ile Gly  Cys Ala Met 
    2360                 2365                 2370             

Leu His  Trp Ser Leu Ile Leu  Pro Gly Ile Lys Ala  Gln Gln Ser 
    2375                 2380                 2385             

Lys Leu  Ala Gln Arg Arg Val  Phe His Gly Val Ala  Lys Asn Pro 
    2390                 2395                 2400             

Val Val  Asp Gly Asn Pro Thr  Val Asp Ile Glu Glu  Ala Pro Glu 
    2405                 2410                 2415             

Met Pro  Ala Leu Tyr Glu Lys  Lys Leu Ala Leu Tyr  Leu Leu Leu 
    2420                 2425                 2430             

Ala Leu  Ser Leu Ala Ser Val  Ala Met Cys Arg Thr  Pro Phe Ser 
    2435                 2440                 2445             

Leu Asp  Glu Gly Ile Val Leu  Ala Ser Ala Ala Leu  Gly Pro Leu 
    2450                 2455                 2460             

Ile Glu  Gly Asn Thr Ser Leu  Leu Trp Asn Gly Pro  Met Ala Val 
    2465                 2470                 2475             

Ser Met  Thr Gly Val Met Arg  Gly Asn Tyr Tyr Ala  Phe Val Gly 
    2480                 2485                 2490             

Val Ala  Tyr Asn Leu Trp Lys  Met Lys Thr Ala Arg  Arg Gly Thr 
    2495                 2500                 2505             

Ala Asn  Gly Lys Thr Leu Gly  Glu Val Trp Lys Arg  Glu Leu Asn 
    2510                 2515                 2520             

Leu Leu  Asp Lys Gln Gln Phe  Glu Leu Tyr Lys Arg  Thr Asp Ile 
    2525                 2530                 2535             

Val Glu  Val Asp Arg Asp Thr  Ala Arg Arg His Leu  Ala Glu Gly 
    2540                 2545                 2550             

Lys Val  Asp Thr Gly Val Ala  Val Ser Arg Gly Thr  Ala Lys Leu 
    2555                 2560                 2565             

Arg Trp  Phe His Glu Arg Gly  Tyr Val Lys Leu Glu  Gly Arg Val 
    2570                 2575                 2580             

Ile Asp  Leu Gly Cys Gly Arg  Gly Gly Trp Cys Tyr  Tyr Ala Ala 
    2585                 2590                 2595             

Ala Gln  Lys Glu Val Ser Gly  Val Lys Gly Phe Thr  Leu Gly Arg 
    2600                 2605                 2610             

Asp Gly  His Glu Lys Pro Met  Asn Val Gln Ser Leu  Gly Trp Asn 
    2615                 2620                 2625             

Ile Ile  Thr Phe Lys Asp Lys  Thr Asp Val His Pro  Leu Glu Pro 
    2630                 2635                 2640             

Val Lys  Cys Asp Thr Leu Leu  Cys Asp Ile Gly Glu  Ser Ser Ser 
    2645                 2650                 2655             

Ser Ser  Val Thr Glu Gly Glu  Arg Thr Val Arg Val  Leu Asp Thr 
    2660                 2665                 2670             

Val Glu  Lys Trp Leu Ala Cys  Gly Val Asp Asn Phe  Cys Val Lys 
    2675                 2680                 2685             

Val Leu  Ala Pro Tyr Met Arg  Asp Val Leu Glu Lys  Leu Glu Leu 
    2690                 2695                 2700             

Leu Gln  Arg Arg Phe Gly Gly  Thr Val Ile Arg Asn  Pro Leu Ser 
    2705                 2710                 2715             

Arg Asn  Ser Thr His Glu Met  Tyr Tyr Val Ser Gly  Ala Arg Ser 
    2720                 2725                 2730             

Asn Val  Thr Phe Thr Val Asn  Gln Thr Ser Arg Leu  Leu Met Arg 
    2735                 2740                 2745             

Arg Met  Arg Arg Pro Thr Gly  Lys Val Thr Leu Glu  Ala Asp Val 
    2750                 2755                 2760             

Thr Leu  Pro Ile Gly Thr Arg  Ser Val Glu Thr Asp  Lys Gly Pro 
    2765                 2770                 2775             

Leu Asp  Lys Glu Ala Ile Lys  Glu Arg Val Glu Arg  Ile Lys Ser 
    2780                 2785                 2790             

Glu Tyr  Met Thr Ser Trp Phe  Tyr Asp Asn Asp Asn  Pro Tyr Arg 
    2795                 2800                 2805             

Thr Trp  His Tyr Cys Gly Ser  Tyr Val Thr Lys Thr  Ser Gly Ser 
    2810                 2815                 2820             

Ala Ala  Ser Met Val Asn Gly  Val Ile Lys Leu Leu  Thr Tyr Pro 
    2825                 2830                 2835             

Trp Asp  Lys Ile Glu Glu Val  Thr Arg Met Ala Met  Thr Asp Thr 
    2840                 2845                 2850             

Thr Pro  Phe Gly Gln Gln Arg  Val Phe Lys Glu Lys  Val Asp Thr 
    2855                 2860                 2865             

Arg Ala  Lys Asp Pro Pro Ala  Gly Thr Arg Lys Ile  Met Lys Val 
    2870                 2875                 2880             

Val Asn  Arg Trp Leu Phe Arg  His Leu Ala Arg Glu  Lys Asn Pro 
    2885                 2890                 2895             

Arg Leu  Cys Thr Lys Glu Glu  Phe Ile Ala Lys Val  Arg Ser His 
    2900                 2905                 2910             

Ala Ala  Ile Gly Ala Tyr Leu  Glu Glu Gln Asp Gln  Trp Lys Thr 
    2915                 2920                 2925             

Ala Asn  Glu Ala Val Gln Asp  Pro Lys Phe Trp Glu  Leu Val Asp 
    2930                 2935                 2940             

Glu Glu  Arg Lys Leu His Gln  Gln Gly Arg Cys Arg  Thr Cys Val 
    2945                 2950                 2955             

Tyr Asn  Met Met Gly Lys Arg  Glu Lys Lys Leu Ser  Glu Phe Gly 
    2960                 2965                 2970             

Lys Ala  Lys Gly Ser Arg Ala  Ile Trp Tyr Met Trp  Leu Gly Ala 
    2975                 2980                 2985             

Arg Tyr  Leu Glu Phe Glu Ala  Leu Gly Phe Leu Asn  Glu Asp His 
    2990                 2995                 3000             

Trp Ala  Ser Arg Glu Asn Ser  Gly Gly Gly Val Glu  Gly Ile Gly 
    3005                 3010                 3015             

Leu Gln  Tyr Leu Gly Tyr Val  Ile Arg Asp Leu Ala  Ala Met Asp 
    3020                 3025                 3030             

Gly Gly  Gly Leu Tyr Ala Asp  Asp Thr Ala Gly Trp  Asp Thr Arg 
    3035                 3040                 3045             

Ile Thr  Glu Ala Asp Leu Asp  Asp Glu Gln Glu Ile  Leu Asn Tyr 
    3050                 3055                 3060             

Met Ser  Pro His His Lys Lys  Leu Ala Gln Ala Val  Met Glu Met 
    3065                 3070                 3075             

Thr Tyr  Lys Asn Lys Val Val  Lys Val Leu Arg Pro  Ala Pro Gly 
    3080                 3085                 3090             

Gly Lys  Ala Tyr Met Asp Val  Ile Ser Arg Arg Asp  Gln Arg Gly 
    3095                 3100                 3105             

Ser Gly  Gln Val Val Thr Tyr  Ala Leu Asn Thr Ile  Thr Asn Leu 
    3110                 3115                 3120             

Lys Val  Gln Leu Ile Arg Met  Ala Glu Ala Glu Met  Val Ile His 
    3125                 3130                 3135             

His Gln  His Val Gln Asp Cys  Asp Glu Ser Val Leu  Thr Arg Leu 
    3140                 3145                 3150             

Glu Ala  Trp Leu Thr Glu His  Gly Cys Asp Arg Leu  Arg Arg Met 
    3155                 3160                 3165             

Ala Val  Ser Gly Asp Asp Cys  Val Val Arg Pro Ile  Asp Asp Arg 
    3170                 3175                 3180             

Phe Gly  Leu Ala Leu Ser His  Leu Asn Ala Met Ser  Lys Val Arg 
    3185                 3190                 3195             

Lys Asp  Ile Ser Glu Trp Gln  Pro Ser Lys Gly Trp  Asn Asp Trp 
    3200                 3205                 3210             

Glu Asn  Val Pro Phe Cys Ser  His His Phe His Glu  Leu Gln Leu 
    3215                 3220                 3225             

Lys Asp  Gly Arg Arg Ile Val  Val Pro Cys Arg Glu  Gln Asp Glu 
    3230                 3235                 3240             

Leu Ile  Gly Arg Gly Arg Val  Ser Pro Gly Asn Gly  Trp Met Ile 
    3245                 3250                 3255             

Lys Glu  Thr Ala Cys Leu Ser  Lys Ala Tyr Ala Asn  Met Trp Ser 
    3260                 3265                 3270             

Leu Met  Tyr Phe His Lys Arg  Asp Met Arg Leu Leu  Ser Leu Ala 
    3275                 3280                 3285             

Val Ser  Ser Ala Val Pro Thr  Ser Trp Val Pro Gln  Gly Arg Thr 
    3290                 3295                 3300             

Thr Trp  Ser Ile His Gly Lys  Gly Glu Trp Met Thr  Thr Glu Asp 
    3305                 3310                 3315             

Arg Leu  Glu Val Trp Asn Arg  Val Trp Ile Thr Asn  Asn Pro His 
    3320                 3325                 3330             

Met Gln  Asp Lys Thr Met Val  Lys Glu Trp Arg Asp  Val Pro Tyr 
    3335                 3340                 3345             

Leu Thr  Lys Arg Gln Asp Lys  Leu Cys Gly Ser Leu  Ile Gly Met 
    3350                 3355                 3360             

Thr Asn  Arg Ala Thr Trp Ala  Ser Asn Ile His Leu  Val Ile His 
    3365                 3370                 3375             

Arg Ile  Arg Thr Leu Val Gly  Gln Glu Lys Tyr Thr  Asp Tyr Leu 
    3380                 3385                 3390             

Thr Val  Met Asp Arg Tyr Ser  Val Asp Ala Asp Leu  Gln Pro Gly 
    3395                 3400                 3405             

Glu Leu  Ile 
    3410     


<210>  18
<211>  261
<212>  PRT
<213>  Homo sapiens

<400> 18

Met Thr Cys Trp Leu Arg Gly Val Thr Ala Thr Phe Gly Arg Pro Ala 
1               5                   10                  15      

Glu Trp Pro Gly Tyr Leu Ser His Leu Cys Gly Arg Ser Ala Ala Met 
            20                  25                  30          

Asp Leu Gly Pro Met Arg Lys Ser Tyr Arg Gly Asp Arg Glu Ala Phe 
        35                  40                  45              

Glu Glu Thr His Leu Thr Ser Leu Asp Pro Val Lys Gln Phe Ala Ala 
    50                  55                  60                  

Trp Phe Glu Glu Ala Val Gln Cys Pro Asp Ile Gly Glu Ala Asn Ala 
65                  70                  75                  80  


Met Cys Leu Ala Thr Cys Thr Arg Asp Gly Lys Pro Ser Ala Arg Met 
                85                  90                  95      

Leu Leu Leu Lys Gly Phe Gly Lys Asp Gly Phe Arg Phe Phe Thr Asn 
            100                 105                 110         

Phe Glu Ser Arg Lys Gly Lys Glu Leu Asp Ser Asn Pro Phe Ala Ser 
        115                 120                 125             

Leu Val Phe Tyr Trp Glu Pro Leu Asn Arg Gln Val Arg Val Glu Gly 
    130                 135                 140                 

Pro Val Lys Lys Leu Pro Glu Glu Glu Ala Glu Cys Tyr Phe His Ser 
145                 150                 155                 160 

Arg Pro Lys Ser Ser Gln Ile Gly Ala Val Val Ser His Gln Ser Ser 
                165                 170                 175     

Val Ile Pro Asp Arg Glu Tyr Leu Arg Lys Lys Asn Glu Glu Leu Glu 
            180                 185                 190         

Gln Leu Tyr Gln Asp Gln Glu Val Pro Lys Pro Lys Ser Trp Gly Gly 
        195                 200                 205             

Tyr Val Leu Tyr Pro Gln Val Met Glu Phe Trp Gln Gly Gln Thr Asn 
    210                 215                 220                 

Arg Leu His Asp Arg Ile Val Phe Arg Arg Gly Leu Pro Thr Gly Asp 
225                 230                 235                 240 

Ser Pro Leu Gly Pro Met Thr His Arg Gly Glu Glu Asp Trp Leu Tyr 
                245                 250                 255     

Glu Arg Leu Ala Pro 
            260     


<210>  19
<211>  11
<212>  PRT
<213>  Homo sapiens

<400> 19

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  20
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 20

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  21
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 21

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  22
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 22

Val Ala Thr Ile Lys Ser Val Ser Phe Tyr Thr Arg Lys 
1               5                   10              


<210>  23
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 23

Arg Pro Pro Gly Phe Ser Pro Phe Arg 
1               5                   


<210>  24
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 24

Val Ala Thr Ile Lys Ser Val Ser Phe Tyr Thr Arg Lys Gly Gly Lys 
1               5                   10                  15      

Leu Ala Lys Leu Ala Lys Lys Leu Ala Lys Leu Ala Lys 
            20                  25                  


<210>  25
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 25

Arg Arg Arg Arg Arg Arg Arg Arg Arg Gly Gly Lys Leu Ala Lys Leu 
1               5                   10                  15      

Ala Lys Lys Leu Ala Lys Leu Ala Lys 
            20                  25  


<210>  26
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 26

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Lys Leu Ala 
1               5                   10                  15      

Lys Leu Ala Lys Lys Leu Ala Lys Leu Ala Lys 
            20                  25          


<210>  27
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 27

Lys Lys Thr Leu Lys Lys Leu Trp Lys Lys Lys Lys Arg Lys Gly Gly 
1               5                   10                  15      

Lys Leu Ala Lys Leu Ala Lys Lys Leu Ala Lys Leu Ala Lys 
            20                  25                  30  


<210>  28
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 28

Lys Lys Thr Cys Arg Arg Ile Asn Tyr Cys Ala Leu Asn Lys Gly Gly 
1               5                   10                  15      

Lys Leu Ala Lys Leu Ala Lys Lys Leu Ala Lys Leu Ala Lys 
            20                  25                  30  


<210>  29
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 29

Arg Arg Arg His Gln Arg Lys Tyr Arg Arg Tyr Gly Gly Lys Leu Ala 
1               5                   10                  15      

Lys Leu Ala Lys Lys Leu Ala Lys Leu Ala Lys 
            20                  25          


<210>  30
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 30

Lys Pro Ser Ala Arg Met Leu Leu Leu Lys Gly Phe Gly Lys Gly Gly 
1               5                   10                  15      

Lys Leu Ala Lys Leu Ala Lys Lys Leu Ala Lys Leu Ala Lys 
            20                  25                  30  


<210>  31
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 31

Lys Leu Ala Lys Leu Ala Lys Lys Leu Ala Lys Leu Ala Lys 
1               5                   10                  


<210>  32
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 32

Phe Leu Arg Arg Arg Arg Arg Phe Thr Arg Gln Thr Gly Gly Lys Leu 
1               5                   10                  15      

Ala Lys Leu Ala Lys Lys Leu Ala Lys Leu Ala Lys 
            20                  25              


<210>  33
<211>  50
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 33

Pro Leu Val Ser Phe Gly Cys Arg Asp Thr Lys Lys Lys Asp Phe Lys 
1               5                   10                  15      

Lys Ser Ser Lys Tyr Lys Ala Tyr Lys Lys Lys Lys Thr Leu Lys Lys 
            20                  25                  30          

Leu Trp Lys Lys Lys Lys Arg Lys Phe Thr Pro Gly Lys Tyr Phe Ser 
        35                  40                  45              

Lys Lys 
    50  


<210>  34
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400> 34

aagaaaacct gcagaaggat caactactgt gcactgaaca aa                        42


<210>  35
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400> 35

aagaaaaccc ttaaaaaact ctggaagaaa aagaaaagaa aa                        42


<210>  36
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400> 36

cgaaggcgcc accagcggaa gtacaggcgc tac                                  33


<210>  37
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400> 37

ttcctacgcc gccgccgccg cttcacccgg cagaca                               36


<210>  38
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400> 38

aagaaactgg ctctatatct ccttcttgct ctc                                  33


<210>  39
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400> 39

aaaccctctg ctcgcatgtt gctgctgaag ggcttcggga aa                        42


<210>  40
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400> 40

Arg Arg Arg Arg Arg Arg Arg Arg Arg Lys 
1               5                   10  


