                         SEQUENCE LISTING

<110>  Okairos AG, et al.
 
<120>  Expression Systems

<130>  578-46

<150>  PCT/EP2010/007995
<151>  2010-12-30

<160>  21     

<170>  PatentIn version 3.5

<210>  1
<211>  360
<212>  PRT
<213>  Respiratory Syncytial Virus


<220>
<221>  F protein minimal sequence
<222>  (1)..(360)

<400>  1

Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu 
1               5                   10                  15      


Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu 
            20                  25                  30          


Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu 
        35                  40                  45              


Pro Ile Val Asn Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val 
    50                  55                  60                  


Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu 
65                  70                  75                  80  


Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu 
                85                  90                  95      


Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn 
            100                 105                 110         


Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln 
        115                 120                 125             


Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val 
    130                 135                 140                 


Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu 
145                 150                 155                 160 


His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile 
                165                 170                 175     


Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser 
            180                 185                 190         


Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg 
        195                 200                 205             


Val Phe Cys Asp Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn 
    210                 215                 220                 


Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met 
225                 230                 235                 240 


Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala 
                245                 250                 255     


Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn 
            260                 265                 270         


Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn 
        275                 280                 285             


Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn 
    290                 295                 300                 


Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn 
305                 310                 315                 320 


Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile 
                325                 330                 335     


Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys 
            340                 345                 350         


Ser Asp Glu Leu Leu His Asn Val 
        355                 360 


<210>  2
<211>  524
<212>  PRT
<213>  Respiratory Syncytial Virus


<220>
<221>  F0deltaTM
<222>  (1)..(524)

<400>  2

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn 
        515                 520                 


<210>  3
<211>  170
<212>  PRT
<213>  Respiratory Syncytial Virus


<220>
<221>  N protein minimal sequence
<222>  (1)..(170)

<400>  3

Ile Lys Ile Leu Arg Asp Ala Gly Tyr His Val Lys Ala Asn Gly Val 
1               5                   10                  15      


Asp Val Thr Thr His Arg Gln Asp Ile Asn Gly Lys Glu Met Lys Phe 
            20                  25                  30          


Glu Val Leu Thr Leu Ala Ser Leu Thr Thr Glu Ile Gln Ile Asn Ile 
        35                  40                  45              


Glu Ile Glu Ser Arg Lys Ser Tyr Lys Lys Met Leu Lys Glu Met Gly 
    50                  55                  60                  


Glu Val Ala Pro Glu Tyr Arg His Asp Ser Pro Asp Cys Gly Met Ile 
65                  70                  75                  80  


Ile Leu Cys Ile Ala Ala Leu Val Ile Thr Lys Leu Ala Ala Gly Asp 
                85                  90                  95      


Arg Ser Gly Leu Thr Ala Val Ile Arg Arg Ala Asn Asn Val Leu Lys 
            100                 105                 110         


Asn Glu Met Lys Arg Tyr Lys Gly Leu Leu Pro Lys Asp Ile Ala Asn 
        115                 120                 125             


Ser Phe Tyr Glu Val Phe Glu Lys Tyr Pro His Phe Ile Asp Val Phe 
    130                 135                 140                 


Val His Phe Gly Ile Ala Gln Ser Ser Thr Arg Gly Gly Ser Arg Val 
145                 150                 155                 160 


Glu Gly Ile Phe Ala Gly Leu Phe Met Asn 
                165                 170 


<210>  4
<211>  391
<212>  PRT
<213>  Respiratory Syncytial Virus


<220>
<221>  N protein
<222>  (1)..(391)

<400>  4

Met Ala Leu Ser Lys Val Lys Leu Asn Asp Thr Leu Asn Lys Asp Gln 
1               5                   10                  15      


Leu Leu Ser Ser Ser Lys Tyr Thr Ile Gln Arg Ser Thr Gly Asp Ser 
            20                  25                  30          


Ile Asp Thr Pro Asn Tyr Asp Val Gln Lys His Ile Asn Lys Leu Cys 
        35                  40                  45              


Gly Met Leu Leu Ile Thr Glu Asp Ala Asn His Lys Phe Thr Gly Leu 
    50                  55                  60                  


Ile Gly Met Leu Tyr Ala Met Ser Arg Leu Gly Arg Glu Asp Thr Ile 
65                  70                  75                  80  


Lys Ile Leu Arg Asp Ala Gly Tyr His Val Lys Ala Asn Gly Val Asp 
                85                  90                  95      


Val Thr Thr His Arg Gln Asp Ile Asn Gly Lys Glu Met Lys Phe Glu 
            100                 105                 110         


Val Leu Thr Leu Ala Ser Leu Thr Thr Glu Ile Gln Ile Asn Ile Glu 
        115                 120                 125             


Ile Glu Ser Arg Lys Ser Tyr Lys Lys Met Leu Lys Glu Met Gly Glu 
    130                 135                 140                 


Val Ala Pro Glu Tyr Arg His Asp Ser Pro Asp Cys Gly Met Ile Ile 
145                 150                 155                 160 


Leu Cys Ile Ala Ala Leu Val Ile Thr Lys Leu Ala Ala Gly Asp Arg 
                165                 170                 175     


Ser Gly Leu Thr Ala Val Ile Arg Arg Ala Asn Asn Val Leu Lys Asn 
            180                 185                 190         


Glu Met Lys Arg Tyr Lys Gly Leu Leu Pro Lys Asp Ile Ala Asn Ser 
        195                 200                 205             


Phe Tyr Glu Val Phe Glu Lys Tyr Pro His Phe Ile Asp Val Phe Val 
    210                 215                 220                 


His Phe Gly Ile Ala Gln Ser Ser Thr Arg Gly Gly Ser Arg Val Glu 
225                 230                 235                 240 


Gly Ile Phe Ala Gly Leu Phe Met Asn Ala Tyr Gly Ala Gly Gln Val 
                245                 250                 255     


Met Leu Arg Trp Gly Val Leu Ala Lys Ser Val Lys Asn Ile Met Leu 
            260                 265                 270         


Gly His Ala Ser Val Gln Ala Glu Met Glu Gln Val Val Glu Val Tyr 
        275                 280                 285             


Glu Tyr Ala Gln Lys Leu Gly Gly Glu Ala Gly Phe Tyr His Ile Leu 
    290                 295                 300                 


Asn Asn Pro Lys Ala Ser Leu Leu Ser Leu Thr Gln Phe Pro His Phe 
305                 310                 315                 320 


Ser Ser Val Val Leu Gly Asn Ala Ala Gly Leu Gly Ile Met Gly Glu 
                325                 330                 335     


Tyr Arg Gly Thr Pro Arg Asn Gln Asp Leu Tyr Asp Ala Ala Lys Ala 
            340                 345                 350         


Tyr Ala Glu Gln Leu Lys Glu Asn Gly Val Ile Asn Tyr Ser Val Leu 
        355                 360                 365             


Asp Leu Thr Ala Glu Glu Leu Glu Ala Ile Lys His Gln Leu Asn Pro 
    370                 375                 380                 


Lys Asp Asn Asp Val Glu Leu 
385                 390     


<210>  5
<211>  194
<212>  PRT
<213>  Respiratory Syncytial Virus


<220>
<221>  M 2-1
<222>  (1)..(194)

<400>  5

Met Ser Arg Arg Asn Pro Cys Lys Phe Glu Ile Arg Gly His Cys Leu 
1               5                   10                  15      


Asn Gly Lys Arg Cys His Phe Ser His Asn Tyr Phe Glu Trp Pro Pro 
            20                  25                  30          


His Ala Leu Leu Val Arg Gln Asn Phe Met Leu Asn Arg Ile Leu Lys 
        35                  40                  45              


Ser Met Asp Lys Ser Ile Asp Thr Leu Ser Glu Ile Ser Gly Ala Ala 
    50                  55                  60                  


Glu Leu Asp Arg Thr Glu Glu Tyr Ala Leu Gly Val Val Gly Val Leu 
65                  70                  75                  80  


Glu Ser Tyr Ile Gly Ser Ile Asn Asn Ile Thr Lys Gln Ser Ala Cys 
                85                  90                  95      


Val Ala Met Ser Lys Leu Leu Thr Glu Leu Asn Ser Asp Asp Ile Lys 
            100                 105                 110         


Lys Leu Arg Asp Asn Glu Glu Leu Asn Ser Pro Lys Ile Arg Val Tyr 
        115                 120                 125             


Asn Thr Val Ile Ser Tyr Ile Glu Ser Asn Arg Lys Asn Asn Lys Gln 
    130                 135                 140                 


Thr Ile His Leu Leu Lys Arg Leu Pro Ala Asp Val Leu Lys Lys Thr 
145                 150                 155                 160 


Ile Lys Asn Thr Leu Asp Ile His Lys Ser Ile Thr Ile Asn Asn Pro 
                165                 170                 175     


Lys Glu Ser Thr Val Ser Asp Thr Asn Asp His Ala Lys Asn Asn Asp 
            180                 185                 190         


Thr Thr 
        


<210>  6
<211>  7
<212>  PRT
<213>  PEPTIDE


<220>
<221>  Peptide Linker
<222>  (1)..(7)

<400>  6

Gly Gly Gly Ser Gly Gly Gly 
1               5           


<210>  7
<211>  1146
<212>  PRT
<213>  Respiratory Syncytial Virus


<220>
<221>  F0deltaTM-N-M2-1
<222>  (1)..(1146)

<400>  7

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Arg Lys Arg Arg 
        515                 520                 525             


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
    530                 535                 540                 


Asp Val Glu Ser Asn Pro Gly Pro Met Ala Leu Ser Lys Val Lys Leu 
545                 550                 555                 560 


Asn Asp Thr Leu Asn Lys Asp Gln Leu Leu Ser Ser Ser Lys Tyr Thr 
                565                 570                 575     


Ile Gln Arg Ser Thr Gly Asp Ser Ile Asp Thr Pro Asn Tyr Asp Val 
            580                 585                 590         


Gln Lys His Ile Asn Lys Leu Cys Gly Met Leu Leu Ile Thr Glu Asp 
        595                 600                 605             


Ala Asn His Lys Phe Thr Gly Leu Ile Gly Met Leu Tyr Ala Met Ser 
    610                 615                 620                 


Arg Leu Gly Arg Glu Asp Thr Ile Lys Ile Leu Arg Asp Ala Gly Tyr 
625                 630                 635                 640 


His Val Lys Ala Asn Gly Val Asp Val Thr Thr His Arg Gln Asp Ile 
                645                 650                 655     


Asn Gly Lys Glu Met Lys Phe Glu Val Leu Thr Leu Ala Ser Leu Thr 
            660                 665                 670         


Thr Glu Ile Gln Ile Asn Ile Glu Ile Glu Ser Arg Lys Ser Tyr Lys 
        675                 680                 685             


Lys Met Leu Lys Glu Met Gly Glu Val Ala Pro Glu Tyr Arg His Asp 
    690                 695                 700                 


Ser Pro Asp Cys Gly Met Ile Ile Leu Cys Ile Ala Ala Leu Val Ile 
705                 710                 715                 720 


Thr Lys Leu Ala Ala Gly Asp Arg Ser Gly Leu Thr Ala Val Ile Arg 
                725                 730                 735     


Arg Ala Asn Asn Val Leu Lys Asn Glu Met Lys Arg Tyr Lys Gly Leu 
            740                 745                 750         


Leu Pro Lys Asp Ile Ala Asn Ser Phe Tyr Glu Val Phe Glu Lys Tyr 
        755                 760                 765             


Pro His Phe Ile Asp Val Phe Val His Phe Gly Ile Ala Gln Ser Ser 
    770                 775                 780                 


Thr Arg Gly Gly Ser Arg Val Glu Gly Ile Phe Ala Gly Leu Phe Met 
785                 790                 795                 800 


Asn Ala Tyr Gly Ala Gly Gln Val Met Leu Arg Trp Gly Val Leu Ala 
                805                 810                 815     


Lys Ser Val Lys Asn Ile Met Leu Gly His Ala Ser Val Gln Ala Glu 
            820                 825                 830         


Met Glu Gln Val Val Glu Val Tyr Glu Tyr Ala Gln Lys Leu Gly Gly 
        835                 840                 845             


Glu Ala Gly Phe Tyr His Ile Leu Asn Asn Pro Lys Ala Ser Leu Leu 
    850                 855                 860                 


Ser Leu Thr Gln Phe Pro His Phe Ser Ser Val Val Leu Gly Asn Ala 
865                 870                 875                 880 


Ala Gly Leu Gly Ile Met Gly Glu Tyr Arg Gly Thr Pro Arg Asn Gln 
                885                 890                 895     


Asp Leu Tyr Asp Ala Ala Lys Ala Tyr Ala Glu Gln Leu Lys Glu Asn 
            900                 905                 910         


Gly Val Ile Asn Tyr Ser Val Leu Asp Leu Thr Ala Glu Glu Leu Glu 
        915                 920                 925             


Ala Ile Lys His Gln Leu Asn Pro Lys Asp Asn Asp Val Glu Leu Gly 
    930                 935                 940                 


Gly Gly Gly Ser Gly Gly Gly Gly Met Ser Arg Arg Asn Pro Cys Lys 
945                 950                 955                 960 


Phe Glu Ile Arg Gly His Cys Leu Asn Gly Lys Arg Cys His Phe Ser 
                965                 970                 975     


His Asn Tyr Phe Glu Trp Pro Pro His Ala Leu Leu Val Arg Gln Asn 
            980                 985                 990         


Phe Met Leu Asn Arg Ile Leu Lys  Ser Met Asp Lys Ser  Ile Asp Thr 
        995                 1000                 1005             


Leu Ser  Glu Ile Ser Gly Ala  Ala Glu Leu Asp Arg  Thr Glu Glu 
    1010                 1015                 1020             


Tyr Ala  Leu Gly Val Val Gly  Val Leu Glu Ser Tyr  Ile Gly Ser 
    1025                 1030                 1035             


Ile Asn  Asn Ile Thr Lys Gln  Ser Ala Cys Val Ala  Met Ser Lys 
    1040                 1045                 1050             


Leu Leu  Thr Glu Leu Asn Ser  Asp Asp Ile Lys Lys  Leu Arg Asp 
    1055                 1060                 1065             


Asn Glu  Glu Leu Asn Ser Pro  Lys Ile Arg Val Tyr  Asn Thr Val 
    1070                 1075                 1080             


Ile Ser  Tyr Ile Glu Ser Asn  Arg Lys Asn Asn Lys  Gln Thr Ile 
    1085                 1090                 1095             


His Leu  Leu Lys Arg Leu Pro  Ala Asp Val Leu Lys  Lys Thr Ile 
    1100                 1105                 1110             


Lys Asn  Thr Leu Asp Ile His  Lys Ser Ile Thr Ile  Asn Asn Pro 
    1115                 1120                 1125             


Lys Glu  Ser Thr Val Ser Asp  Thr Asn Asp His Ala  Lys Asn Asn 
    1130                 1135                 1140             


Asp Thr  Thr 
    1145     



<210>  8
<211>  566
<212>  PRT
<213>  Influenza A virus


<220>
<221>  HA subtype H1 consensus sequence
<222>  (1)..(566)

<400>  8

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Ser Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210>  9
<211>  570
<212>  PRT
<213>  Influenza A virus


<220>
<221>  HA subtype H1 consensus sequence modified H0 cleavage site
<222>  (1)..(570)

<400>  9

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Ser Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly 
            340                 345                 350         


Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly 
        355                 360                 365             


Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala 
    370                 375                 380                 


Asp Leu Lys Ser Thr Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val 
385                 390                 395                 400 


Asn Ser Val Ile Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys 
                405                 410                 415     


Glu Phe Asn His Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val 
            420                 425                 430         


Asp Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val 
        435                 440                 445             


Leu Leu Glu Asn Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys 
    450                 455                 460                 


Asn Leu Tyr Glu Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu 
465                 470                 475                 480 


Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys 
                485                 490                 495     


Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu 
            500                 505                 510         


Glu Ala Lys Leu Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser 
        515                 520                 525             


Thr Arg Ile Tyr Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser 
    530                 535                 540                 


Leu Val Leu Val Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser 
545                 550                 555                 560 


Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
                565                 570 


<210>  10
<211>  568
<212>  PRT
<213>  Influenza A virus


<220>
<221>  HA subtype H5 consensus sequence
<222>  (1)..(568)

<400>  10

Met Glu Lys Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Arg Ser Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Arg Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr 
        355                 360                 365             


Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys 
    370                 375                 380                 


Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser 
385                 390                 395                 400 


Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe 
                405                 410                 415     


Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp 
            420                 425                 430         


Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met 
        435                 440                 445             


Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu 
    450                 455                 460                 


Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu 
                485                 490                 495     


Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala 
            500                 505                 510         


Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly 
        515                 520                 525             


Thr Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala 
    530                 535                 540                 


Leu Ala Ile Met Val Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly 
545                 550                 555                 560 


Ser Leu Gln Cys Arg Ile Cys Ile 
                565             


<210>  11
<211>  498
<212>  PRT
<213>  Influenza A virus


<220>
<221>  NP consensus sequence
<222>  (1)..(498)

<400>  11

Met Ala Ser Gln Gly Ala Ala Ala Ser Tyr Glu Gln Met Glu Thr Asp 
1               5                   10                  15      


Gly Asp Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Lys Met 
            20                  25                  30          


Ile Asp Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Leu Thr Ile Glu 
    50                  55                  60                  


Lys Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Arg Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Arg Arg Val Asp Gly Lys Trp Met Arg Glu Leu Val Leu Tyr Asp 
            100                 105                 110         


Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Glu Asp 
        115                 120                 125             


Ala Thr Ala Gly Leu Thr His Met Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Thr Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Val Lys Gly Ile Gly Thr Met Val Met Glu 
            180                 185                 190         


Leu Ile Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Glu Asn Gly Arg Lys Thr Arg Ser Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Met Asp 
225                 230                 235                 240 


Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu 
                245                 250                 255     


Ile Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Pro Ala Val Ala Ser Gly 
        275                 280                 285             


Tyr Asp Phe Glu Lys Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 


Lys Leu Leu Gln Asn Ser Gln Val Tyr Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Leu Ser Ser Phe Ile Arg Gly Thr Lys Val 
            340                 345                 350         


Ser Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Met Asp Asn Met Gly Ser Ser Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 


Ala Ser Ala Gly Gln Ile Ser Val Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Glu Lys Ser Thr Ile Met Ala Ala Phe Thr Gly Asn 
            420                 425                 430         


Thr Glu Gly Arg Thr Ser Asp Met Arg Ala Glu Ile Ile Arg Met Met 
        435                 440                 445             


Glu Ser Ala Lys Pro Glu Glu Val Ser Phe Arg Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Glu Lys Ala Thr Asn Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     


Asp Asn 
        


<210>  12
<211>  252
<212>  PRT
<213>  Influenza A virus


<220>
<221>  M1 consensus sequence
<222>  (1)..(252)

<400>  12

Met Ser Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Val Pro 
1               5                   10                  15      


Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe 
            20                  25                  30          


Ala Gly Lys Asn Thr Asp Leu Glu Ala Leu Met Glu Trp Leu Lys Thr 
        35                  40                  45              


Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe 
    50                  55                  60                  


Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val 
65                  70                  75                  80  


Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala 
                85                  90                  95      


Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala 
            100                 105                 110         


Lys Glu Ile Ala Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met 
        115                 120                 125             


Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe 
    130                 135                 140                 


Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg 
145                 150                 155                 160 


Ser His Arg Gln Met Val Thr Thr Thr Asn Pro Leu Ile Arg His Glu 
                165                 170                 175     


Asn Arg Met Val Leu Ala Ser Thr Thr Ala Lys Ala Met Glu Gln Met 
            180                 185                 190         


Ala Gly Ser Ser Glu Gln Ala Ala Glu Ala Met Glu Ile Ala Ser Gln 
        195                 200                 205             


Ala Arg Gln Met Val Gln Ala Met Arg Thr Ile Gly Thr His Pro Ser 
    210                 215                 220                 


Ser Ser Thr Gly Leu Arg Asp Asp Leu Leu Glu Asn Leu Gln Thr Tyr 
225                 230                 235                 240 


Gln Lys Arg Met Gly Val Gln Met Gln Arg Phe Lys 
                245                 250         


<210>  13
<211>  1357
<212>  PRT
<213>  Influenza A virus


<220>
<221>  NP-M1-H1p
<222>  (1)..(1357)

<400>  13

Met Ala Ser Gln Gly Ala Ala Ala Ser Tyr Glu Gln Met Glu Thr Asp 
1               5                   10                  15      


Gly Asp Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Lys Met 
            20                  25                  30          


Ile Asp Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Leu Thr Ile Glu 
    50                  55                  60                  


Lys Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Arg Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Arg Arg Val Asp Gly Lys Trp Met Arg Glu Leu Val Leu Tyr Asp 
            100                 105                 110         


Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Glu Asp 
        115                 120                 125             


Ala Thr Ala Gly Leu Thr His Met Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Thr Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Val Lys Gly Ile Gly Thr Met Val Met Glu 
            180                 185                 190         


Leu Ile Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Glu Asn Gly Arg Lys Thr Arg Ser Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Met Asp 
225                 230                 235                 240 


Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu 
                245                 250                 255     


Ile Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Pro Ala Val Ala Ser Gly 
        275                 280                 285             


Tyr Asp Phe Glu Lys Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 


Lys Leu Leu Gln Asn Ser Gln Val Tyr Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Leu Ser Ser Phe Ile Arg Gly Thr Lys Val 
            340                 345                 350         


Ser Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Met Asp Asn Met Gly Ser Ser Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 


Ala Ser Ala Gly Gln Ile Ser Val Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Glu Lys Ser Thr Ile Met Ala Ala Phe Thr Gly Asn 
            420                 425                 430         


Thr Glu Gly Arg Thr Ser Asp Met Arg Ala Glu Ile Ile Arg Met Met 
        435                 440                 445             


Glu Ser Ala Lys Pro Glu Glu Val Ser Phe Arg Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Glu Lys Ala Thr Asn Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     


Asp Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Met Ser Leu Leu Thr 
            500                 505                 510         


Glu Val Glu Thr Tyr Val Leu Ser Ile Val Pro Ser Gly Pro Leu Lys 
        515                 520                 525             


Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn Thr 
    530                 535                 540                 


Asp Leu Glu Ala Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu Ser 
545                 550                 555                 560 


Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val Pro 
                565                 570                 575     


Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu Asn 
            580                 585                 590         


Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr Arg 
        595                 600                 605             


Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ala Leu 
    610                 615                 620                 


Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr Asn 
625                 630                 635                 640 


Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys Ala 
                645                 650                 655     


Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg Ser His Arg Gln Met 
            660                 665                 670         


Val Thr Thr Thr Asn Pro Leu Ile Arg His Glu Asn Arg Met Val Leu 
        675                 680                 685             


Ala Ser Thr Thr Ala Lys Ala Met Glu Gln Met Ala Gly Ser Ser Glu 
    690                 695                 700                 


Gln Ala Ala Glu Ala Met Glu Ile Ala Ser Gln Ala Arg Gln Met Val 
705                 710                 715                 720 


Gln Ala Met Arg Thr Ile Gly Thr His Pro Ser Ser Ser Thr Gly Leu 
                725                 730                 735     


Arg Asp Asp Leu Leu Glu Asn Leu Gln Thr Tyr Gln Lys Arg Met Gly 
            740                 745                 750         


Val Gln Met Gln Arg Phe Lys Arg Lys Arg Arg Ala Pro Val Lys Gln 
        755                 760                 765             


Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
    770                 775                 780                 


Pro Gly Pro Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala 
785                 790                 795                 800 


Thr Ala Asn Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser 
                805                 810                 815     


Thr Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His 
            820                 825                 830         


Ser Val Asn Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu 
        835                 840                 845             


Arg Gly Val Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp 
    850                 855                 860                 


Ile Leu Gly Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp 
865                 870                 875                 880 


Ser Tyr Ile Val Glu Thr Ser Ser Ser Asp Asn Gly Thr Cys Tyr Pro 
                885                 890                 895     


Gly Asp Phe Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val 
            900                 905                 910         


Ser Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro 
        915                 920                 925             


Asn His Asp Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly 
    930                 935                 940                 


Ala Lys Ser Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn 
945                 950                 955                 960 


Ser Tyr Pro Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu 
                965                 970                 975     


Val Leu Val Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln 
            980                 985                 990         


Gln Ser Leu Tyr Gln Asn Ala Asp  Ala Tyr Val Phe Val  Gly Ser Ser 
        995                 1000                 1005             


Arg Tyr  Ser Lys Lys Phe Lys  Pro Glu Ile Ala Ile  Arg Pro Lys 
    1010                 1015                 1020             


Val Arg  Asp Gln Glu Gly Arg  Met Asn Tyr Tyr Trp  Thr Leu Val 
    1025                 1030                 1035             


Glu Pro  Gly Asp Lys Ile Thr  Phe Glu Ala Thr Gly  Asn Leu Val 
    1040                 1045                 1050             


Val Pro  Arg Tyr Ala Phe Ala  Met Glu Arg Asn Ala  Gly Ser Gly 
    1055                 1060                 1065             


Ile Ile  Ile Ser Asp Thr Pro  Val His Asp Cys Asn  Thr Thr Cys 
    1070                 1075                 1080             


Gln Thr  Pro Lys Gly Ala Ile  Asn Thr Ser Leu Pro  Phe Gln Asn 
    1085                 1090                 1095             


Ile His  Pro Ile Thr Ile Gly  Lys Cys Pro Lys Tyr  Val Lys Ser 
    1100                 1105                 1110             


Thr Lys  Leu Arg Leu Ala Thr  Gly Leu Arg Asn Ile  Pro Gln Arg 
    1115                 1120                 1125             


Glu Arg  Arg Arg Lys Lys Arg  Gly Leu Phe Gly Ala  Ile Ala Gly 
    1130                 1135                 1140             


Phe Ile  Glu Gly Gly Trp Thr  Gly Met Val Asp Gly  Trp Tyr Gly 
    1145                 1150                 1155             


Tyr His  His Gln Asn Glu Gln  Gly Ser Gly Tyr Ala  Ala Asp Leu 
    1160                 1165                 1170             


Lys Ser  Thr Gln Asn Ala Ile  Asp Glu Ile Thr Asn  Lys Val Asn 
    1175                 1180                 1185             


Ser Val  Ile Glu Lys Met Asn  Thr Gln Phe Thr Ala  Val Gly Lys 
    1190                 1195                 1200             


Glu Phe  Asn His Leu Glu Lys  Arg Ile Glu Asn Leu  Asn Lys Lys 
    1205                 1210                 1215             


Val Asp  Asp Gly Phe Leu Asp  Ile Trp Thr Tyr Asn  Ala Glu Leu 
    1220                 1225                 1230             


Leu Val  Leu Leu Glu Asn Glu  Arg Thr Leu Asp Tyr  His Asp Ser 
    1235                 1240                 1245             


Asn Val  Lys Asn Leu Tyr Glu  Lys Val Arg Ser Gln  Leu Lys Asn 
    1250                 1255                 1260             


Asn Ala  Lys Glu Ile Gly Asn  Gly Cys Phe Glu Phe  Tyr His Lys 
    1265                 1270                 1275             


Cys Asp  Asn Thr Cys Met Glu  Ser Val Lys Asn Gly  Thr Tyr Asp 
    1280                 1285                 1290             


Tyr Pro  Lys Tyr Ser Glu Glu  Ala Lys Leu Asn Arg  Glu Glu Ile 
    1295                 1300                 1305             


Asp Gly  Val Lys Leu Glu Ser  Thr Arg Ile Tyr Gln  Ile Leu Ala 
    1310                 1315                 1320             


Ile Tyr  Ser Thr Val Ala Ser  Ser Leu Val Leu Val  Val Ser Leu 
    1325                 1330                 1335             


Gly Ala  Ile Ser Phe Trp Met  Cys Ser Asn Gly Ser  Leu Gln Cys 
    1340                 1345                 1350             


Arg Ile  Cys Ile 
    1355         


<210>  14
<211>  4079
<212>  DNA
<213>  Influenza A virus


<220>
<221>  NP-M1-H1p
<222>  (1)..(4079)

<400>  14
atggcctctc agggcgcagc cgccagctac gagcagatgg aaaccgacgg cgacagacag       60

aacgccaccg agatcagagc cagcgtgggc aagatgatcg acggcatcgg ccggttctac      120

atccagatgt gcaccgagct gaagctgtcc gactacgagg gccggctgat ccagaacagc      180

ctgaccatcg agaagatggt gctgtccgcc ttcgacgagc ggcggaatag atacctggaa      240

gaacacccca gcgccggcaa ggaccctaag aaaaccggcg gacccatcta cagacgggtg      300

gacggcaagt ggatgcggga gctggtgctg tacgacaaag aggaaatcag aagaatctgg      360

cggcaggcca acaatggcga ggatgccaca gccggcctga cccacatgat gatctggcac      420

agcaacctga acgacaccac ctaccagcgg acaagagccc tcgtgcggac cggcatggac      480

ccccggatgt gcagcctgat gcagggcagc acactgccta gaagatctgg cgccgctggc      540

gctgccgtga agggcatcgg caccatggtc atggaactga tccggatgat caagcggggc      600

atcaacgacc ggaacttttg gagaggcgag aacggcagaa agaccagatc cgcctacgag      660

cggatgtgca acatcctgaa gggcaagttc cagacagccg cccagagggc aatgatggac      720

caggtccggg agagcagaaa ccccggcaac gccgagatcg aggacctgat cttcctggcc      780

agaagcgccc tgatcctgag aggcagcgtg gcccacaaga gctgcctgcc cgcctgtgtg      840

tatggaccag ccgtggctag cggctacgac ttcgagaaag agggctacag cctcgtcggc      900

atcgacccct tcaagctgct gcagaacagc caggtgtaca gcctgatccg gcccaacgag      960

aaccctgccc acaagtccca gctcgtgtgg atggcctgcc acagcgccgc cttcgaggat     1020

ctgcggctgt ccagcttcat ccggggcacc aaggtgtccc ccagaggcaa gctgtctacc     1080

agaggcgtgc agatcgccag caacgagaac atggacaaca tgggcagcag caccctggaa     1140

ctgcggagcc ggtactgggc catcagaacc agaagcggcg gcaacaccaa ccagcagaga     1200

gccagcgccg gacagatcag cgtgcagccc accttctccg tgcagcggaa tctgcccttc     1260

gagaagtcca ccatcatggc cgccttcacc ggcaataccg agggccggac cagcgacatg     1320

cgggccgaga tcatcagaat gatggaaagc gccaagcccg aggaagtgtc cttccggggc     1380

agaggcgtgt tcgagctgtc cgatgagaag gccaccaacc ccatcgtgcc cagcttcgac     1440

atgagcaacg agggcagcta cttcttcggc gacaacgccg aggaatacga caatggcggc     1500

ggaggatctg ggggcggagg catgagtctg ctgactgaag tcgagacata cgtgctgtcc     1560

atcgtgccta gcggccctct gaaggccgag atcgcccagc ggctggaaga tgtgttcgcc     1620

ggcaagaaca ccgacctgga agccctgatg gaatggctga aaacccggcc catcctgagc     1680

cctctgacca agggcatcct gggcttcgtg ttcaccctga ccgtgccctc tgagcggggc     1740

ctgcagcgga gaagattcgt gcagaacgcc ctgaacggca acggcgaccc caacaacatg     1800

gataaggccg tgaagctgta ccggaagctg aagcgggaga tcaccttcca cggcgccaaa     1860

gagatcgccc tgtcctactc tgccggcgct ctggccagct gcatgggcct catctacaac     1920

cggatgggcg ccgtgaccac agaggtggcc ttcggcctcg tgtgtgccac ttgcgagcag     1980

atcgccgaca gccagcaccg gtcccacaga cagatggtca ccaccaccaa ccctctgatc     2040

cggcacgaga accggatggt gctcgcctct accaccgcca aggccatgga acagatggcc     2100

ggcagcagcg aacaggccgc cgaagccatg gaaatcgcca gccaggccag gcagatggtc     2160

caggccatgc ggaccatcgg cacccaccct agcagctcca ccggcctgcg ggacgatctg     2220

ctggaaaatc tgcagaccta tcagaaacgg atgggggtgc agatgcagcg gttcaagagg     2280

aaaagacgtg cgccagtaaa gcagacatta aactttgatt tgctgaaact tgcaggtgat     2340

gtagagtcaa atccaggtcc aatgaaggcc atcctggtgg tgctgctgta caccttcgcc     2400

accgccaacg ccgacaccct gtgcattggg tatcatgcca acaactccac cgacaccgtg     2460

gataccgtgc tggaaaagaa tgtgacagtc acccacagcg tgaacctgct ggaagataag     2520

cacaatggga agctgtgcaa gctgcggggc gtggcccctc tgcacctggg caagtgcaat     2580

atcgccggct ggatcctggg aaatcctgag tgcgagagcc tgagcaccgc cagcagctgg     2640

tcttacatcg tcgagacaag cagcagcgac aacggcacct gttaccccgg cgatttcatt     2700

gattatgagg aactgcgcga gcagctgtcc tccgtgtcca gcttcgagag attcgagatc     2760

ttccctaaga ccagctcctg gcccaaccac gactccaaca agggcgtgac cgccgcctgt     2820

cctcacgctg gcgccaagag cttctacaag aacctgatct ggctcgtcaa gaagggcaac     2880

tcctacccca agctgagcaa gagctacatc aacgacaagg gcaaagaggt cctcgtcctc     2940

tggggaattc atcaccctag caccagcgcc gaccagcaga gcctgtatca gaacgccgac     3000

gcctacgtgt tcgtgggcag cagccggtac agcaagaagt tcaagcctga gatcgccatc     3060

agacccaaag tgcgggacca ggaaggccgg atgaactact actggaccct ggtggaaccc     3120

ggcgacaaga tcaccttcga ggccaccggc aatctggtgg tgcccagata cgccttcgcc     3180

atggaacgga acgccggcag cggcatcatc atcagcgaca cccccgtgca cgactgcaat     3240

accacctgtc agacacctaa gggggccatc aacacctccc tgcctttcca gaatatccac     3300

cctatcacca tcgggaagtg tcctaaatat gtcaagagca ccaagctgcg gctggccaca     3360

ggactgagaa acatccccca gagagagcgg agacggaaga agcggggcct gttcggcgct     3420

atcgctggat tcattgaggg cggatggacc ggcatggtcg atgggtggta tgggtatcat     3480

caccagaatg agcagggctc cggatatgcc gccgatctga agtccactca gaacgccatc     3540

gacgagatca caaacaaagt caactccgtg atcgagaaaa tgaatactca gttcaccgcc     3600

gtcgggaaag agttcaatca cctggagaag cgcatcgaga atctcaacaa aaaggtcgac     3660

gacggcttcc tcgacatctg gacatacaat gctgaactgc tcgtgctgct ggagaatgag     3720

agaaccctgg attaccacga ttccaacgtc aagaatctct atgagaaagt gcggagccag     3780

ctgaagaaca atgccaaaga aatcgggaat ggctgttttg agttttatca caagtgtgat     3840

aacacctgta tggaatccgt gaagaatggc acatacgatt accctaagta ctccgaagag     3900

gccaagctga acagagaaga gatcgacggg gtcaagctgg aaagcacccg gatctatcag     3960

atcctggcca tctattctac cgtggcctcc tccctggtgc tggtggtgtc cctgggcgct     4020

atcagcttct ggatgtgctc caatggctcc ctgcagtgca gaatctgtat ttgataatt      4079


<210>  15
<211>  10
<212>  PRT
<213>  Influenza A virus


<220>
<221>  H0 cleavage site sequence
<222>  (1)..(10)

<400>  15

Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg 
1               5                   10  


<210>  16
<211>  10
<212>  PRT
<213>  Influenza A virus


<220>
<221>  H0 cleavage site sequence
<222>  (1)..(10)

<400>  16

Pro Gln Arg Glu Ser Arg Arg Lys Lys Arg 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Influenza A virus


<220>
<221>  H0 cleavage site sequence
<222>  (1)..(10)

<400>  17

Pro Gln Gly Glu Arg Arg Arg Lys Lys Arg 
1               5                   10  


<210>  18
<211>  9
<212>  PRT
<213>  Influenza A virus


<220>
<221>  H0 cleavage site sequence
<222>  (1)..(9)

<400>  18

Pro Leu Arg Glu Arg Arg Arg Lys Arg 
1               5                   


<210>  19
<211>  6
<212>  PRT
<213>  Influenza A virus


<220>
<221>  H0 cleavage site sequence
<222>  (1)..(6)

<400>  19

Pro Gln Arg Glu Thr Arg 
1               5       



<210>  20
<211>  566
<212>  PRT
<213>  Influenza A virus


<220>
<221>  HA subtype H3 strain A/Wellington/01/2004(H3N2)
<222>  (1)..(566)

<400>  20

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Lys Arg Arg Ser Asn 
145                 150                 155                 160 


Lys Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Lys Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Asn Asp Gln Ile 
        195                 200                 205             


Ser Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Val Arg 
225                 230                 235                 240 


Asp Val Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  21
<211>  566
<212>  PRT
<213>  Influenza A virus


<220>
<221>  HA subtype H3 strain A/Wellington/01/2004(H3N2) modified H0 
       cleavage site
<222>  (1)..(566)

<400>  21

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Lys Arg Arg Ser Asn 
145                 150                 155                 160 


Lys Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Lys Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Asn Asp Gln Ile 
        195                 200                 205             


Ser Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Val Arg 
225                 230                 235                 240 


Asp Val Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Ile Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     



