                               SEQUENCE LISTING	

<110> GENENTECH, INC. ET AL.
 
<120> PILRALPHA INTERACTIONS AND METHODS OF MODIFYING SAME

<130> P4572R1 WO

<140>
<141>

<150> 61/510,453
<151> 2011-07-21

<150> 61/426,945
<151> 2010-12-23

<160> 63    

<170> PatentIn version 3.5

<210> 1
<211> 302
<212> PRT
<213> Mus sp.

<400> 1
Met Ala Leu Leu Ile Ser Leu Pro Gly Gly Thr Pro Ala Met Ala Gln 
1               5                   10                  15      


Ile Leu Leu Leu Leu Ser Ser Ala Cys Leu His Ala Gly Asn Ser Glu 
            20                  25                  30          


Arg Ser Asn Arg Lys Asn Gly Phe Gly Val Asn Gln Pro Glu Ser Cys 
        35                  40                  45              


Ser Gly Val Gln Gly Gly Ser Ile Asp Ile Pro Phe Ser Phe Tyr Phe 
    50                  55                  60                  


Pro Trp Lys Leu Ala Lys Asp Pro Gln Met Ser Ile Ala Trp Arg Trp 
65                  70                  75                  80  


Lys Asp Phe His Gly Glu Phe Ile Tyr Asn Ser Ser Leu Pro Phe Ile 
                85                  90                  95      


His Glu His Phe Lys Gly Arg Leu Ile Leu Asn Trp Thr Gln Gly Gln 
            100                 105                 110         


Thr Ser Gly Val Leu Arg Ile Leu Asn Leu Lys Glu Ser Asp Gln Thr 
        115                 120                 125             


Arg Tyr Phe Gly Arg Val Phe Leu Gln Thr Thr Glu Gly Ile Gln Phe 
    130                 135                 140                 


Trp Gln Ser Ile Pro Gly Thr Gln Leu Asn Val Thr Asn Ala Thr Cys 
145                 150                 155                 160 


Thr Pro Thr Thr Leu Pro Ser Thr Thr Ala Ala Thr Ser Ala His Thr 
                165                 170                 175     


Gln Asn Asp Ile Thr Glu Val Lys Ser Ala Asn Ile Gly Gly Leu Asp 
            180                 185                 190         


Leu Gln Thr Thr Val Gly Leu Ala Thr Ala Ala Ala Val Phe Leu Val 
        195                 200                 205             


Gly Val Leu Gly Leu Ile Val Phe Leu Trp Trp Lys Arg Arg Arg Gln 
    210                 215                 220                 


Gly Gln Lys Thr Lys Ala Glu Ile Pro Ala Arg Glu Pro Leu Glu Thr 
225                 230                 235                 240 


Ser Glu Lys His Glu Ser Val Gly His Glu Gly Gln Cys Met Asp Pro 
                245                 250                 255     


Lys Glu Asn Pro Lys Asp Asn Asn Ile Val Tyr Ala Ser Ile Ser Leu 
            260                 265                 270         


Ser Ser Pro Thr Ser Pro Gly Thr Ala Pro Asn Leu Pro Val His Gly 
        275                 280                 285             


Asn Pro Gln Glu Glu Thr Val Tyr Ser Ile Val Lys Ala Lys 
    290                 295                 300         


<210> 2
<211> 274
<212> PRT
<213> Mus sp.

<400> 2
Gly Asn Ser Glu Arg Ser Asn Arg Lys Asn Gly Phe Gly Val Asn Gln 
1               5                   10                  15      


Pro Glu Ser Cys Ser Gly Val Gln Gly Gly Ser Ile Asp Ile Pro Phe 
            20                  25                  30          


Ser Phe Tyr Phe Pro Trp Lys Leu Ala Lys Asp Pro Gln Met Ser Ile 
        35                  40                  45              


Ala Trp Arg Trp Lys Asp Phe His Gly Glu Phe Ile Tyr Asn Ser Ser 
    50                  55                  60                  


Leu Pro Phe Ile His Glu His Phe Lys Gly Arg Leu Ile Leu Asn Trp 
65                  70                  75                  80  


Thr Gln Gly Gln Thr Ser Gly Val Leu Arg Ile Leu Asn Leu Lys Glu 
                85                  90                  95      


Ser Asp Gln Thr Arg Tyr Phe Gly Arg Val Phe Leu Gln Thr Thr Glu 
            100                 105                 110         


Gly Ile Gln Phe Trp Gln Ser Ile Pro Gly Thr Gln Leu Asn Val Thr 
        115                 120                 125             


Asn Ala Thr Cys Thr Pro Thr Thr Leu Pro Ser Thr Thr Ala Ala Thr 
    130                 135                 140                 


Ser Ala His Thr Gln Asn Asp Ile Thr Glu Val Lys Ser Ala Asn Ile 
145                 150                 155                 160 


Gly Gly Leu Asp Leu Gln Thr Thr Val Gly Leu Ala Thr Ala Ala Ala 
                165                 170                 175     


Val Phe Leu Val Gly Val Leu Gly Leu Ile Val Phe Leu Trp Trp Lys 
            180                 185                 190         


Arg Arg Arg Gln Gly Gln Lys Thr Lys Ala Glu Ile Pro Ala Arg Glu 
        195                 200                 205             


Pro Leu Glu Thr Ser Glu Lys His Glu Ser Val Gly His Glu Gly Gln 
    210                 215                 220                 


Cys Met Asp Pro Lys Glu Asn Pro Lys Asp Asn Asn Ile Val Tyr Ala 
225                 230                 235                 240 


Ser Ile Ser Leu Ser Ser Pro Thr Ser Pro Gly Thr Ala Pro Asn Leu 
                245                 250                 255     


Pro Val His Gly Asn Pro Gln Glu Glu Thr Val Tyr Ser Ile Val Lys 
            260                 265                 270         


Ala Lys 
        


<210> 3
<211> 303
<212> PRT
<213> Homo sapiens

<400> 3
Met Gly Arg Pro Leu Leu Leu Pro Leu Leu Pro Leu Leu Leu Pro Pro 
1               5                   10                  15      


Ala Phe Leu Gln Pro Ser Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu 
            20                  25                  30          


Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser 
        35                  40                  45              


Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Thr Ala 
    50                  55                  60                  


Pro Asp Val Arg Ile Ser Trp Arg Arg Gly His Phe His Arg Gln Ser 
65                  70                  75                  80  


Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg 
                85                  90                  95      


Leu Phe Leu Asn Trp Thr Glu Gly Gln Lys Ser Gly Phe Leu Arg Ile 
            100                 105                 110         


Ser Asn Leu Gln Lys Gln Asp Gln Ser Val Tyr Phe Cys Arg Val Glu 
        115                 120                 125             


Leu Asp Thr Arg Ser Ser Gly Arg Gln Gln Trp Gln Ser Ile Glu Gly 
    130                 135                 140                 


Thr Lys Leu Ser Ile Thr Gln Ala Val Thr Thr Thr Thr Gln Arg Pro 
145                 150                 155                 160 


Ser Ser Met Thr Thr Thr Trp Arg Leu Ser Ser Thr Thr Thr Thr Thr 
                165                 170                 175     


Gly Leu Arg Val Thr Gln Gly Lys Arg Arg Ser Asp Ser Trp His Ile 
            180                 185                 190         


Ser Leu Glu Thr Ala Val Gly Val Ala Val Ala Val Thr Val Leu Gly 
        195                 200                 205             


Ile Met Ile Leu Gly Leu Ile Cys Leu Leu Arg Trp Arg Arg Arg Lys 
    210                 215                 220                 


Gly Gln Gln Arg Thr Lys Ala Thr Thr Pro Ala Arg Glu Pro Phe Gln 
225                 230                 235                 240 


Asn Thr Glu Glu Pro Tyr Glu Asn Ile Arg Asn Glu Gly Gln Asn Thr 
                245                 250                 255     


Asp Pro Lys Leu Asn Pro Lys Asp Asp Gly Ile Val Tyr Ala Ser Leu 
            260                 265                 270         


Ala Leu Ser Ser Ser Thr Ser Pro Arg Ala Pro Pro Ser His Arg Pro 
        275                 280                 285             


Leu Lys Ser Pro Gln Asn Glu Thr Leu Tyr Ser Val Leu Lys Ala 
    290                 295                 300             


<210> 4
<211> 284
<212> PRT
<213> Homo sapiens

<400> 4
Gln Pro Ser Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu Tyr Gly Val 
1               5                   10                  15      


Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser Val Glu Ile 
            20                  25                  30          


Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Thr Ala Pro Asp Val 
        35                  40                  45              


Arg Ile Ser Trp Arg Arg Gly His Phe His Arg Gln Ser Phe Tyr Ser 
    50                  55                  60                  


Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg Leu Phe Leu 
65                  70                  75                  80  


Asn Trp Thr Glu Gly Gln Lys Ser Gly Phe Leu Arg Ile Ser Asn Leu 
                85                  90                  95      


Gln Lys Gln Asp Gln Ser Val Tyr Phe Cys Arg Val Glu Leu Asp Thr 
            100                 105                 110         


Arg Ser Ser Gly Arg Gln Gln Trp Gln Ser Ile Glu Gly Thr Lys Leu 
        115                 120                 125             


Ser Ile Thr Gln Ala Val Thr Thr Thr Thr Gln Arg Pro Ser Ser Met 
    130                 135                 140                 


Thr Thr Thr Trp Arg Leu Ser Ser Thr Thr Thr Thr Thr Gly Leu Arg 
145                 150                 155                 160 


Val Thr Gln Gly Lys Arg Arg Ser Asp Ser Trp His Ile Ser Leu Glu 
                165                 170                 175     


Thr Ala Val Gly Val Ala Val Ala Val Thr Val Leu Gly Ile Met Ile 
            180                 185                 190         


Leu Gly Leu Ile Cys Leu Leu Arg Trp Arg Arg Arg Lys Gly Gln Gln 
        195                 200                 205             


Arg Thr Lys Ala Thr Thr Pro Ala Arg Glu Pro Phe Gln Asn Thr Glu 
    210                 215                 220                 


Glu Pro Tyr Glu Asn Ile Arg Asn Glu Gly Gln Asn Thr Asp Pro Lys 
225                 230                 235                 240 


Leu Asn Pro Lys Asp Asp Gly Ile Val Tyr Ala Ser Leu Ala Leu Ser 
                245                 250                 255     


Ser Ser Thr Ser Pro Arg Ala Pro Pro Ser His Arg Pro Leu Lys Ser 
            260                 265                 270         


Pro Gln Asn Glu Thr Leu Tyr Ser Val Leu Lys Ala 
        275                 280                 


<210> 5
<211> 325
<212> PRT
<213> Homo sapiens

<400> 5
Met Ala Thr Pro Leu Pro Pro Pro Ser Pro Arg His Leu Arg Leu Leu 
1               5                   10                  15      


Arg Leu Leu Leu Ser Gly Leu Val Leu Gly Ala Ala Leu Arg Gly Ala 
            20                  25                  30          


Ala Ala Gly His Pro Asp Val Ala Ala Cys Pro Gly Ser Leu Asp Cys 
        35                  40                  45              


Ala Leu Lys Arg Arg Ala Arg Cys Pro Pro Gly Ala His Ala Cys Gly 
    50                  55                  60                  


Pro Cys Leu Gln Pro Phe Gln Glu Asp Gln Gln Gly Leu Cys Val Pro 
65                  70                  75                  80  


Arg Met Arg Arg Pro Pro Gly Gly Gly Arg Pro Gln Pro Arg Leu Glu 
                85                  90                  95      


Asp Glu Ile Asp Phe Leu Ala Gln Glu Leu Ala Arg Lys Glu Ser Gly 
            100                 105                 110         


Gln Ser Thr Pro Pro Leu Pro Lys Asp Arg Gln Arg Leu Pro Glu Pro 
        115                 120                 125             


Ala Thr Leu Gly Phe Ser Ala Arg Gly Gln Gly Leu Glu Leu Gly Leu 
    130                 135                 140                 


Pro Ser Thr Pro Gly Thr Pro Thr Pro Thr Pro His Thr Ser Leu Gly 
145                 150                 155                 160 


Ser Pro Val Ser Ser Asp Pro Val His Met Ser Pro Leu Glu Pro Arg 
                165                 170                 175     


Gly Gly Gln Gly Asp Gly Leu Ala Leu Val Leu Ile Leu Ala Phe Cys 
            180                 185                 190         


Val Ala Gly Ala Ala Ala Leu Ser Val Ala Ser Leu Cys Trp Cys Arg 
        195                 200                 205             


Leu Gln Arg Glu Ile Arg Leu Thr Gln Lys Ala Asp Tyr Ala Thr Ala 
    210                 215                 220                 


Lys Ala Pro Gly Ser Pro Ala Ala Pro Arg Ile Ser Pro Gly Asp Gln 
225                 230                 235                 240 


Arg Leu Ala Gln Ser Ala Glu Met Tyr His Tyr Gln His Gln Arg Gln 
                245                 250                 255     


Gln Met Leu Cys Leu Glu Arg His Lys Glu Pro Pro Lys Glu Leu Asp 
            260                 265                 270         


Thr Ala Ser Ser Asp Glu Glu Asn Glu Asp Gly Asp Phe Thr Val Tyr 
        275                 280                 285             


Glu Cys Pro Gly Leu Ala Pro Thr Gly Glu Met Glu Val Arg Asn Pro 
    290                 295                 300                 


Leu Phe Asp His Ala Ala Leu Ser Ala Pro Leu Pro Ala Pro Ser Ser 
305                 310                 315                 320 


Pro Pro Ala Leu Pro 
                325 


<210> 6
<211> 291
<212> PRT
<213> Homo sapiens

<400> 6
Gly His Pro Asp Val Ala Ala Cys Pro Gly Ser Leu Asp Cys Ala Leu 
1               5                   10                  15      


Lys Arg Arg Ala Arg Cys Pro Pro Gly Ala His Ala Cys Gly Pro Cys 
            20                  25                  30          


Leu Gln Pro Phe Gln Glu Asp Gln Gln Gly Leu Cys Val Pro Arg Met 
        35                  40                  45              


Arg Arg Pro Pro Gly Gly Gly Arg Pro Gln Pro Arg Leu Glu Asp Glu 
    50                  55                  60                  


Ile Asp Phe Leu Ala Gln Glu Leu Ala Arg Lys Glu Ser Gly Gln Ser 
65                  70                  75                  80  


Thr Pro Pro Leu Pro Lys Asp Arg Gln Arg Leu Pro Glu Pro Ala Thr 
                85                  90                  95      


Leu Gly Phe Ser Ala Arg Gly Gln Gly Leu Glu Leu Gly Leu Pro Ser 
            100                 105                 110         


Thr Pro Gly Thr Pro Thr Pro Thr Pro His Thr Ser Leu Gly Ser Pro 
        115                 120                 125             


Val Ser Ser Asp Pro Val His Met Ser Pro Leu Glu Pro Arg Gly Gly 
    130                 135                 140                 


Gln Gly Asp Gly Leu Ala Leu Val Leu Ile Leu Ala Phe Cys Val Ala 
145                 150                 155                 160 


Gly Ala Ala Ala Leu Ser Val Ala Ser Leu Cys Trp Cys Arg Leu Gln 
                165                 170                 175     


Arg Glu Ile Arg Leu Thr Gln Lys Ala Asp Tyr Ala Thr Ala Lys Ala 
            180                 185                 190         


Pro Gly Ser Pro Ala Ala Pro Arg Ile Ser Pro Gly Asp Gln Arg Leu 
        195                 200                 205             


Ala Gln Ser Ala Glu Met Tyr His Tyr Gln His Gln Arg Gln Gln Met 
    210                 215                 220                 


Leu Cys Leu Glu Arg His Lys Glu Pro Pro Lys Glu Leu Asp Thr Ala 
225                 230                 235                 240 


Ser Ser Asp Glu Glu Asn Glu Asp Gly Asp Phe Thr Val Tyr Glu Cys 
                245                 250                 255     


Pro Gly Leu Ala Pro Thr Gly Glu Met Glu Val Arg Asn Pro Leu Phe 
            260                 265                 270         


Asp His Ala Ala Leu Ser Ala Pro Leu Pro Ala Pro Ser Ser Pro Pro 
        275                 280                 285             


Ala Leu Pro 
    290     


<210> 7
<211> 742
<212> PRT
<213> Homo sapiens

<400> 7
Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 
1               5                   10                  15      


Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn 
            20                  25                  30          


Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 
        35                  40                  45              


Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys 
    50                  55                  60                  


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
65                  70                  75                  80  


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
                85                  90                  95      


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
            100                 105                 110         


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
        115                 120                 125             


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
145                 150                 155                 160 


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
                165                 170                 175     


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
            180                 185                 190         


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
        195                 200                 205             


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
    210                 215                 220                 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
225                 230                 235                 240 


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
                245                 250                 255     


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
            260                 265                 270         


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
        275                 280                 285             


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
    290                 295                 300                 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
305                 310                 315                 320 


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
                325                 330                 335     


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
            340                 345                 350         


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
        355                 360                 365             


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
    370                 375                 380                 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
385                 390                 395                 400 


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
                405                 410                 415     


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
            420                 425                 430         


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
        435                 440                 445             


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
    450                 455                 460                 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
                485                 490                 495     


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
            500                 505                 510         


Ser Pro Gly Lys Pro Gly Pro Gln Gly Pro Ser Gly Asp Pro Gly Pro 
        515                 520                 525             


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
    530                 535                 540                 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
545                 550                 555                 560 


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
                565                 570                 575     


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
            580                 585                 590         


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Ser Cys Pro 
        595                 600                 605             


Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu 
    610                 615                 620                 


Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 
625                 630                 635                 640 


His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys 
                645                 650                 655     


Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu 
            660                 665                 670         


Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys 
        675                 680                 685             


Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro 
    690                 695                 700                 


Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe 
705                 710                 715                 720 


Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr 
                725                 730                 735     


Val Leu Ser Ser Ala Leu 
            740         


<210> 8
<211> 442
<212> PRT
<213> Homo sapiens

<400> 8
Met Gln Pro Pro Pro Ser Leu Cys Gly Arg Ala Leu Val Ala Leu Val 
1               5                   10                  15      


Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro 
            20                  25                  30          


Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr Ala Glu Ile Met Thr Pro 
        35                  40                  45              


Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg 
    50                  55                  60                  


Ser Leu Ala Pro Ala Glu Val Pro Lys Gly Asp Arg Thr Ala Gly Ser 
65                  70                  75                  80  


Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile 
                85                  90                  95      


Lys Glu Thr Phe Lys Tyr Ile Asn Thr Val Val Ser Cys Leu Val Phe 
            100                 105                 110         


Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 
        115                 120                 125             


Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 
    130                 135                 140                 


Leu Gly Asp Leu Leu His Ile Val Ile Asp Ile Pro Ile Asn Val Tyr 
145                 150                 155                 160 


Lys Leu Leu Ala Glu Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 
                165                 170                 175     


Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 
            180                 185                 190         


Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
        195                 200                 205             


Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 
    210                 215                 220                 


Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 
225                 230                 235                 240 


Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu 
                245                 250                 255     


Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 
            260                 265                 270         


Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 
        275                 280                 285             


Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 
    290                 295                 300                 


Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 
305                 310                 315                 320 


Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 
                325                 330                 335     


Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln 
            340                 345                 350         


Asn Asp Pro Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 
        355                 360                 365             


Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 
    370                 375                 380                 


Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys 
385                 390                 395                 400 


Leu Cys Cys Trp Cys Gln Ser Phe Glu Glu Lys Gln Ser Leu Glu Glu 
                405                 410                 415     


Lys Gln Ser Cys Leu Lys Phe Lys Ala Asn Asp His Gly Tyr Asp Asn 
            420                 425                 430         


Phe Arg Ser Ser Asn Lys Tyr Ser Ser Ser 
        435                 440         


<210> 9
<211> 416
<212> PRT
<213> Homo sapiens

<400> 9
Glu Glu Arg Gly Phe Pro Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr 
1               5                   10                  15      


Ala Glu Ile Met Thr Pro Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser 
            20                  25                  30          


Asn Ala Ser Leu Ala Arg Ser Leu Ala Pro Ala Glu Val Pro Lys Gly 
        35                  40                  45              


Asp Arg Thr Ala Gly Ser Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys 
    50                  55                  60                  


Gln Gly Pro Ile Glu Ile Lys Glu Thr Phe Lys Tyr Ile Asn Thr Val 
65                  70                  75                  80  


Val Ser Cys Leu Val Phe Val Leu Gly Ile Ile Gly Asn Ser Thr Leu 
                85                  90                  95      


Leu Arg Ile Ile Tyr Lys Asn Lys Cys Met Arg Asn Gly Pro Asn Ile 
            100                 105                 110         


Leu Ile Ala Ser Leu Ala Leu Gly Asp Leu Leu His Ile Val Ile Asp 
        115                 120                 125             


Ile Pro Ile Asn Val Tyr Lys Leu Leu Ala Glu Asp Trp Pro Phe Gly 
    130                 135                 140                 


Ala Glu Met Cys Lys Leu Val Pro Phe Ile Gln Lys Ala Ser Val Gly 
145                 150                 155                 160 


Ile Thr Val Leu Ser Leu Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala 
                165                 170                 175     


Val Ala Ser Trp Ser Arg Ile Lys Gly Ile Gly Val Pro Lys Trp Thr 
            180                 185                 190         


Ala Val Glu Ile Val Leu Ile Trp Val Val Ser Val Val Leu Ala Val 
        195                 200                 205             


Pro Glu Ala Ile Gly Phe Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser 
    210                 215                 220                 


Tyr Leu Arg Ile Cys Leu Leu His Pro Val Gln Lys Thr Ala Phe Met 
225                 230                 235                 240 


Gln Phe Tyr Lys Thr Ala Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe 
                245                 250                 255     


Cys Leu Pro Leu Ala Ile Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys 
            260                 265                 270         


Glu Met Leu Arg Lys Lys Ser Gly Met Gln Ile Ala Leu Asn Asp His 
        275                 280                 285             


Leu Lys Gln Arg Arg Glu Val Ala Lys Thr Val Phe Cys Leu Val Leu 
    290                 295                 300                 


Val Phe Ala Leu Cys Trp Leu Pro Leu His Leu Ser Arg Ile Leu Lys 
305                 310                 315                 320 


Leu Thr Leu Tyr Asn Gln Asn Asp Pro Asn Arg Cys Glu Leu Leu Ser 
                325                 330                 335     


Phe Leu Leu Val Leu Asp Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn 
            340                 345                 350         


Ser Cys Ile Asn Pro Ile Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys 
        355                 360                 365             


Asn Cys Phe Lys Ser Cys Leu Cys Cys Trp Cys Gln Ser Phe Glu Glu 
    370                 375                 380                 


Lys Gln Ser Leu Glu Glu Lys Gln Ser Cys Leu Lys Phe Lys Ala Asn 
385                 390                 395                 400 


Asp His Gly Tyr Asp Asn Phe Arg Ser Ser Asn Lys Tyr Ser Ser Ser 
                405                 410                 415     


<210> 10
<211> 293
<212> PRT
<213> Homo sapiens

<400> 10
Met Asp Thr Thr Arg Tyr Ser Lys Trp Gly Gly Ser Ser Glu Glu Val 
1               5                   10                  15      


Pro Gly Gly Pro Trp Gly Arg Trp Val His Trp Ser Arg Arg Pro Leu 
            20                  25                  30          


Phe Leu Ala Leu Ala Val Leu Val Thr Thr Val Leu Trp Ala Val Ile 
        35                  40                  45              


Leu Ser Ile Leu Leu Ser Lys Ala Ser Thr Glu Arg Ala Ala Leu Leu 
    50                  55                  60                  


Asp Gly His Asp Leu Leu Arg Thr Asn Ala Ser Lys Gln Thr Ala Ala 
65                  70                  75                  80  


Leu Gly Ala Leu Lys Glu Glu Val Gly Asp Cys His Ser Cys Cys Ser 
                85                  90                  95      


Gly Thr Gln Ala Gln Leu Gln Thr Thr Arg Ala Glu Leu Gly Glu Ala 
            100                 105                 110         


Gln Ala Lys Leu Met Glu Gln Glu Ser Ala Leu Arg Glu Leu Arg Glu 
        115                 120                 125             


Arg Val Thr Gln Gly Leu Ala Glu Ala Gly Arg Gly Arg Glu Asp Val 
    130                 135                 140                 


Arg Thr Glu Leu Phe Arg Ala Leu Glu Ala Val Arg Leu Gln Asn Asn 
145                 150                 155                 160 


Ser Cys Glu Pro Cys Pro Thr Ser Trp Leu Ser Phe Glu Gly Ser Cys 
                165                 170                 175     


Tyr Phe Phe Ser Val Pro Lys Thr Thr Trp Ala Ala Ala Gln Asp His 
            180                 185                 190         


Cys Ala Asp Ala Ser Ala His Leu Val Ile Val Gly Gly Leu Asp Glu 
        195                 200                 205             


Gln Gly Phe Leu Thr Arg Asn Thr Arg Gly Arg Gly Tyr Trp Leu Gly 
    210                 215                 220                 


Leu Arg Ala Val Arg His Leu Gly Lys Val Gln Gly Tyr Gln Trp Val 
225                 230                 235                 240 


Asp Gly Val Ser Leu Ser Phe Ser His Trp Asn Gln Gly Glu Pro Asn 
                245                 250                 255     


Asp Ala Trp Gly Arg Glu Asn Cys Val Met Met Leu His Thr Gly Leu 
            260                 265                 270         


Trp Asn Asp Ala Pro Cys Asp Ser Glu Lys Asp Gly Trp Ile Cys Glu 
        275                 280                 285             


Lys Arg His Asn Cys 
    290             


<210> 11
<211> 247
<212> PRT
<213> Homo sapiens

<400> 11
Val Ile Leu Ser Ile Leu Leu Ser Lys Ala Ser Thr Glu Arg Ala Ala 
1               5                   10                  15      


Leu Leu Asp Gly His Asp Leu Leu Arg Thr Asn Ala Ser Lys Gln Thr 
            20                  25                  30          


Ala Ala Leu Gly Ala Leu Lys Glu Glu Val Gly Asp Cys His Ser Cys 
        35                  40                  45              


Cys Ser Gly Thr Gln Ala Gln Leu Gln Thr Thr Arg Ala Glu Leu Gly 
    50                  55                  60                  


Glu Ala Gln Ala Lys Leu Met Glu Gln Glu Ser Ala Leu Arg Glu Leu 
65                  70                  75                  80  


Arg Glu Arg Val Thr Gln Gly Leu Ala Glu Ala Gly Arg Gly Arg Glu 
                85                  90                  95      


Asp Val Arg Thr Glu Leu Phe Arg Ala Leu Glu Ala Val Arg Leu Gln 
            100                 105                 110         


Asn Asn Ser Cys Glu Pro Cys Pro Thr Ser Trp Leu Ser Phe Glu Gly 
        115                 120                 125             


Ser Cys Tyr Phe Phe Ser Val Pro Lys Thr Thr Trp Ala Ala Ala Gln 
    130                 135                 140                 


Asp His Cys Ala Asp Ala Ser Ala His Leu Val Ile Val Gly Gly Leu 
145                 150                 155                 160 


Asp Glu Gln Gly Phe Leu Thr Arg Asn Thr Arg Gly Arg Gly Tyr Trp 
                165                 170                 175     


Leu Gly Leu Arg Ala Val Arg His Leu Gly Lys Val Gln Gly Tyr Gln 
            180                 185                 190         


Trp Val Asp Gly Val Ser Leu Ser Phe Ser His Trp Asn Gln Gly Glu 
        195                 200                 205             


Pro Asn Asp Ala Trp Gly Arg Glu Asn Cys Val Met Met Leu His Thr 
    210                 215                 220                 


Gly Leu Trp Asn Asp Ala Pro Cys Asp Ser Glu Lys Asp Gly Trp Ile 
225                 230                 235                 240 


Cys Glu Lys Arg His Asn Cys 
                245         


<210> 12
<211> 184
<212> PRT
<213> Homo sapiens

<400> 12
Met Arg Arg Gly Pro Arg Ser Leu Arg Gly Arg Asp Ala Pro Ala Pro 
1               5                   10                  15      


Thr Pro Cys Val Pro Ala Glu Cys Phe Asp Leu Leu Val Arg His Cys 
            20                  25                  30          


Val Ala Cys Gly Leu Leu Arg Thr Pro Arg Pro Lys Pro Ala Gly Ala 
        35                  40                  45              


Ser Ser Pro Ala Pro Arg Thr Ala Leu Gln Pro Gln Glu Ser Val Gly 
    50                  55                  60                  


Ala Gly Ala Gly Glu Ala Ala Leu Pro Leu Pro Gly Leu Leu Phe Gly 
65                  70                  75                  80  


Ala Pro Ala Leu Leu Gly Leu Ala Leu Val Leu Ala Leu Val Leu Val 
                85                  90                  95      


Gly Leu Val Ser Trp Arg Arg Arg Gln Arg Arg Leu Arg Gly Ala Ser 
            100                 105                 110         


Ser Ala Glu Ala Pro Asp Gly Asp Lys Asp Ala Pro Glu Pro Leu Asp 
        115                 120                 125             


Lys Val Ile Ile Leu Ser Pro Gly Ile Ser Asp Ala Thr Ala Pro Ala 
    130                 135                 140                 


Trp Pro Pro Pro Gly Glu Asp Pro Gly Thr Thr Pro Pro Gly His Ser 
145                 150                 155                 160 


Val Pro Val Pro Ala Thr Glu Leu Gly Ser Thr Glu Leu Val Thr Thr 
                165                 170                 175     


Lys Thr Ala Gly Pro Glu Gln Gln 
            180                 


<210> 13
<211> 626
<212> PRT
<213> Homo sapiens

<400> 13
Met Ile Phe Leu Thr Ala Leu Pro Leu Phe Trp Ile Met Ile Ser Ala 
1               5                   10                  15      


Ser Arg Gly Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala 
            20                  25                  30          


Phe Glu Gly Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp 
        35                  40                  45              


Glu Leu Arg Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro 
    50                  55                  60                  


Tyr Pro Lys Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val 
65                  70                  75                  80  


Val His Glu Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly 
                85                  90                  95      


Leu Arg Asn Cys Thr Leu Leu Leu Ser Asn Val Ser Pro Glu Leu Gly 
            100                 105                 110         


Gly Lys Tyr Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr 
        115                 120                 125             


Phe Ser Glu His Ser Val Leu Asp Ile Val Asn Thr Pro Asn Ile Val 
    130                 135                 140                 


Val Pro Pro Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met 
145                 150                 155                 160 


Val Pro Asp Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly 
                165                 170                 175     


His Glu Gly Leu Gly Glu Pro Ala Val Leu Gly Arg Leu Arg Glu Asp 
            180                 185                 190         


Glu Gly Thr Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg 
        195                 200                 205             


Glu Ala Asn Gly His Arg Leu Gly Cys Gln Ala Ser Phe Pro Asn Thr 
    210                 215                 220                 


Thr Leu Gln Phe Glu Gly Tyr Ala Ser Met Asp Val Lys Tyr Pro Pro 
225                 230                 235                 240 


Val Ile Val Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His 
                245                 250                 255     


Val Ser Leu Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr 
            260                 265                 270         


Trp Met Arg Asp Gly Thr Val Leu Arg Glu Ala Val Ala Glu Ser Leu 
        275                 280                 285             


Leu Leu Glu Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Val Tyr Ala 
    290                 295                 300                 


Cys Leu Ala Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Gly Leu 
305                 310                 315                 320 


Ser Val Met Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Met Val 
                325                 330                 335     


Ala Val Glu Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn 
            340                 345                 350         


Pro Asp Pro Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ser Thr 
        355                 360                 365             


Val Ile Tyr Glu Ser Glu Leu Gln Leu Glu Leu Pro Ala Val Ser Pro 
    370                 375                 380                 


Glu Asp Asp Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln 
385                 390                 395                 400 


Arg Ala Thr Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Val Leu Leu 
                405                 410                 415     


Leu Glu Ser His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys 
            420                 425                 430         


Val Val Lys Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser 
        435                 440                 445             


Arg Asn Val Thr Val Asn Glu Ser Glu Arg Glu Phe Val Tyr Ser Glu 
    450                 455                 460                 


Arg Ser Gly Leu Val Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala 
465                 470                 475                 480 


Gln Ala Pro Pro Arg Val Ile Cys Thr Ala Arg Asn Leu Tyr Gly Ala 
                485                 490                 495     


Lys Ser Leu Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala 
            500                 505                 510         


Lys Ile Gly Pro Val Gly Ala Val Val Ala Phe Ala Ile Leu Ile Ala 
        515                 520                 525             


Ile Val Cys Tyr Ile Thr Gln Thr Arg Arg Lys Lys Asn Val Thr Glu 
    530                 535                 540                 


Ser Pro Ser Phe Ser Ala Gly Asp Asn Pro Pro Val Leu Phe Ser Ser 
545                 550                 555                 560 


Asp Phe Arg Ile Ser Gly Ala Pro Glu Lys Tyr Glu Ser Glu Arg Arg 
                565                 570                 575     


Leu Gly Ser Glu Arg Arg Leu Leu Gly Leu Arg Gly Glu Pro Pro Glu 
            580                 585                 590         


Leu Asp Leu Ser Tyr Ser His Ser Asp Leu Gly Lys Arg Pro Thr Lys 
        595                 600                 605             


Asp Ser Tyr Thr Leu Thr Glu Glu Leu Ala Glu Tyr Ala Glu Ile Arg 
    610                 615                 620                 


Val Lys 
625     


<210> 14
<211> 607
<212> PRT
<213> Homo sapiens

<400> 14
Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala Phe Glu Gly 
1               5                   10                  15      


Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp Glu Leu Arg 
            20                  25                  30          


Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro Tyr Pro Lys 
        35                  40                  45              


Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val Val His Glu 
    50                  55                  60                  


Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly Leu Arg Asn 
65                  70                  75                  80  


Cys Thr Leu Leu Leu Ser Asn Val Ser Pro Glu Leu Gly Gly Lys Tyr 
                85                  90                  95      


Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr Phe Ser Glu 
            100                 105                 110         


His Ser Val Leu Asp Ile Val Asn Thr Pro Asn Ile Val Val Pro Pro 
        115                 120                 125             


Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met Val Pro Asp 
    130                 135                 140                 


Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly His Glu Gly 
145                 150                 155                 160 


Leu Gly Glu Pro Ala Val Leu Gly Arg Leu Arg Glu Asp Glu Gly Thr 
                165                 170                 175     


Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg Glu Ala Asn 
            180                 185                 190         


Gly His Arg Leu Gly Cys Gln Ala Ser Phe Pro Asn Thr Thr Leu Gln 
        195                 200                 205             


Phe Glu Gly Tyr Ala Ser Met Asp Val Lys Tyr Pro Pro Val Ile Val 
    210                 215                 220                 


Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His Val Ser Leu 
225                 230                 235                 240 


Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr Trp Met Arg 
                245                 250                 255     


Asp Gly Thr Val Leu Arg Glu Ala Val Ala Glu Ser Leu Leu Leu Glu 
            260                 265                 270         


Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Val Tyr Ala Cys Leu Ala 
        275                 280                 285             


Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Gly Leu Ser Val Met 
    290                 295                 300                 


Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Met Val Ala Val Glu 
305                 310                 315                 320 


Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn Pro Asp Pro 
                325                 330                 335     


Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ser Thr Val Ile Tyr 
            340                 345                 350         


Glu Ser Glu Leu Gln Leu Glu Leu Pro Ala Val Ser Pro Glu Asp Asp 
        355                 360                 365             


Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln Arg Ala Thr 
    370                 375                 380                 


Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Val Leu Leu Leu Glu Ser 
385                 390                 395                 400 


His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys Val Val Lys 
                405                 410                 415     


Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser Arg Asn Val 
            420                 425                 430         


Thr Val Asn Glu Ser Glu Arg Glu Phe Val Tyr Ser Glu Arg Ser Gly 
        435                 440                 445             


Leu Val Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala Gln Ala Pro 
    450                 455                 460                 


Pro Arg Val Ile Cys Thr Ala Arg Asn Leu Tyr Gly Ala Lys Ser Leu 
465                 470                 475                 480 


Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala Lys Ile Gly 
                485                 490                 495     


Pro Val Gly Ala Val Val Ala Phe Ala Ile Leu Ile Ala Ile Val Cys 
            500                 505                 510         


Tyr Ile Thr Gln Thr Arg Arg Lys Lys Asn Val Thr Glu Ser Pro Ser 
        515                 520                 525             


Phe Ser Ala Gly Asp Asn Pro Pro Val Leu Phe Ser Ser Asp Phe Arg 
    530                 535                 540                 


Ile Ser Gly Ala Pro Glu Lys Tyr Glu Ser Glu Arg Arg Leu Gly Ser 
545                 550                 555                 560 


Glu Arg Arg Leu Leu Gly Leu Arg Gly Glu Pro Pro Glu Leu Asp Leu 
                565                 570                 575     


Ser Tyr Ser His Ser Asp Leu Gly Lys Arg Pro Thr Lys Asp Ser Tyr 
            580                 585                 590         


Thr Leu Thr Glu Glu Leu Ala Glu Tyr Ala Glu Ile Arg Val Lys 
        595                 600                 605         


<210> 15
<211> 272
<212> PRT
<213> Homo sapiens

<400> 15
Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
        115                 120                 125             


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
    130                 135                 140                 


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
145                 150                 155                 160 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
                165                 170                 175     


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 
            180                 185                 190         


Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 
        195                 200                 205             


Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 
    210                 215                 220                 


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
225                 230                 235                 240 


Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
                245                 250                 255     


Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
            260                 265                 270         


<210> 16
<211> 251
<212> PRT
<213> Homo sapiens

<400> 16
Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln Val Ala Val Ala Gly 
    210                 215                 220                 


Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu Ser Gly Leu Thr Trp 
225                 230                 235                 240 


Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
                245                 250     


<210> 17
<211> 321
<212> PRT
<213> Homo sapiens

<400> 17
Met Glu Glu Gly Gln Tyr Ser Glu Ile Glu Glu Leu Pro Arg Arg Arg 
1               5                   10                  15      


Cys Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala 
            20                  25                  30          


Ala Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp 
        35                  40                  45              


Thr Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val 
    50                  55                  60                  


Ser Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala 
65                  70                  75                  80  


Gln Lys Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg 
                85                  90                  95      


Ala Glu Gln Gln Arg Leu Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn 
            100                 105                 110         


Leu Asn Gly Leu Gln Ala Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu 
        115                 120                 125             


Asn Glu Arg Asn Glu Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu 
    130                 135                 140                 


Val Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys 
145                 150                 155                 160 


Asn Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr 
                165                 170                 175     


Phe Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp 
            180                 185                 190         


Asp Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp 
        195                 200                 205             


Phe Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg 
    210                 215                 220                 


Asn Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val 
225                 230                 235                 240 


Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly 
                245                 250                 255     


Glu Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Thr Asp Ala Phe 
            260                 265                 270         


Cys Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys 
        275                 280                 285             


Thr Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser 
    290                 295                 300                 


Arg Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His 
305                 310                 315                 320 


Ser 
    


<210> 18
<211> 590
<212> PRT
<213> Homo sapiens

<400> 18
Met Gly Phe His Leu Ile Thr Gln Leu Lys Gly Met Ser Val Val Leu 
1               5                   10                  15      


Val Leu Leu Pro Thr Leu Leu Leu Val Met Leu Thr Gly Ala Gln Arg 
            20                  25                  30          


Ala Cys Pro Lys Asn Cys Arg Cys Asp Gly Lys Ile Val Tyr Cys Glu 
        35                  40                  45              


Ser His Ala Phe Ala Asp Ile Pro Glu Asn Ile Ser Gly Gly Ser Gln 
    50                  55                  60                  


Gly Leu Ser Leu Arg Phe Asn Ser Ile Gln Lys Leu Lys Ser Asn Gln 
65                  70                  75                  80  


Phe Ala Gly Leu Asn Gln Leu Ile Trp Leu Tyr Leu Asp His Asn Tyr 
                85                  90                  95      


Ile Ser Ser Val Asp Glu Asp Ala Phe Gln Gly Ile Arg Arg Leu Lys 
            100                 105                 110         


Glu Leu Ile Leu Ser Ser Asn Lys Ile Thr Tyr Leu His Asn Lys Thr 
        115                 120                 125             


Phe His Pro Val Pro Asn Leu Arg Asn Leu Asp Leu Ser Tyr Asn Lys 
    130                 135                 140                 


Leu Gln Thr Leu Gln Ser Glu Gln Phe Lys Gly Leu Arg Lys Leu Ile 
145                 150                 155                 160 


Ile Leu His Leu Arg Ser Asn Ser Leu Lys Thr Val Pro Ile Arg Val 
                165                 170                 175     


Phe Gln Asp Cys Arg Asn Leu Asp Phe Leu Asp Leu Gly Tyr Asn Arg 
            180                 185                 190         


Leu Arg Ser Leu Ser Arg Asn Ala Phe Ala Gly Leu Leu Lys Leu Lys 
        195                 200                 205             


Glu Leu His Leu Glu His Asn Gln Phe Ser Lys Ile Asn Phe Ala His 
    210                 215                 220                 


Phe Pro Arg Leu Phe Asn Leu Arg Ser Ile Tyr Leu Gln Trp Asn Arg 
225                 230                 235                 240 


Ile Arg Ser Ile Ser Gln Gly Leu Thr Trp Thr Trp Ser Ser Leu His 
                245                 250                 255     


Asn Leu Asp Leu Ser Gly Asn Asp Ile Gln Gly Ile Glu Pro Gly Thr 
            260                 265                 270         


Phe Lys Cys Leu Pro Asn Leu Gln Lys Leu Asn Leu Asp Ser Asn Lys 
        275                 280                 285             


Leu Thr Asn Ile Ser Gln Glu Thr Val Asn Ala Trp Ile Ser Leu Ile 
    290                 295                 300                 


Ser Ile Thr Leu Ser Gly Asn Met Trp Glu Cys Ser Arg Ser Ile Cys 
305                 310                 315                 320 


Pro Leu Phe Tyr Trp Leu Lys Asn Phe Lys Gly Asn Lys Glu Ser Thr 
                325                 330                 335     


Met Ile Cys Ala Gly Pro Lys His Ile Gln Gly Glu Lys Val Ser Asp 
            340                 345                 350         


Ala Val Glu Thr Tyr Asn Ile Cys Ser Glu Val Gln Val Val Asn Thr 
        355                 360                 365             


Glu Arg Ser His Leu Val Pro Gln Thr Pro Gln Lys Pro Leu Ile Ile 
    370                 375                 380                 


Pro Arg Pro Thr Ile Phe Lys Pro Asp Val Thr Gln Ser Thr Phe Glu 
385                 390                 395                 400 


Thr Pro Ser Pro Ser Pro Gly Phe Gln Ile Pro Gly Ala Glu Gln Glu 
                405                 410                 415     


Tyr Glu His Val Ser Phe His Lys Ile Ile Ala Gly Ser Val Ala Leu 
            420                 425                 430         


Phe Leu Ser Val Ala Met Ile Leu Leu Val Ile Tyr Val Ser Trp Lys 
        435                 440                 445             


Arg Tyr Pro Ala Ser Met Lys Gln Leu Gln Gln His Ser Leu Met Lys 
    450                 455                 460                 


Arg Arg Arg Lys Lys Ala Arg Glu Ser Glu Arg Gln Met Asn Ser Pro 
465                 470                 475                 480 


Leu Gln Glu Tyr Tyr Val Asp Tyr Lys Pro Thr Asn Ser Glu Thr Met 
                485                 490                 495     


Asp Ile Ser Val Asn Gly Ser Gly Pro Cys Thr Tyr Thr Ile Ser Gly 
            500                 505                 510         


Ser Arg Glu Cys Glu Met Pro His His Met Lys Pro Leu Pro Tyr Tyr 
        515                 520                 525             


Ser Tyr Asp Gln Pro Val Ile Gly Tyr Cys Gln Ala His Gln Pro Leu 
    530                 535                 540                 


His Val Thr Lys Gly Tyr Glu Thr Val Ser Pro Glu Gln Asp Glu Ser 
545                 550                 555                 560 


Pro Gly Leu Glu Leu Gly Arg Asp His Ser Phe Ile Ala Thr Ile Ala 
                565                 570                 575     


Arg Ser Ala Ala Pro Ala Ile Tyr Leu Glu Arg Ile Ala Asn 
            580                 585                 590 


<210> 19
<211> 560
<212> PRT
<213> Homo sapiens

<400> 19
Gln Arg Ala Cys Pro Lys Asn Cys Arg Cys Asp Gly Lys Ile Val Tyr 
1               5                   10                  15      


Cys Glu Ser His Ala Phe Ala Asp Ile Pro Glu Asn Ile Ser Gly Gly 
            20                  25                  30          


Ser Gln Gly Leu Ser Leu Arg Phe Asn Ser Ile Gln Lys Leu Lys Ser 
        35                  40                  45              


Asn Gln Phe Ala Gly Leu Asn Gln Leu Ile Trp Leu Tyr Leu Asp His 
    50                  55                  60                  


Asn Tyr Ile Ser Ser Val Asp Glu Asp Ala Phe Gln Gly Ile Arg Arg 
65                  70                  75                  80  


Leu Lys Glu Leu Ile Leu Ser Ser Asn Lys Ile Thr Tyr Leu His Asn 
                85                  90                  95      


Lys Thr Phe His Pro Val Pro Asn Leu Arg Asn Leu Asp Leu Ser Tyr 
            100                 105                 110         


Asn Lys Leu Gln Thr Leu Gln Ser Glu Gln Phe Lys Gly Leu Arg Lys 
        115                 120                 125             


Leu Ile Ile Leu His Leu Arg Ser Asn Ser Leu Lys Thr Val Pro Ile 
    130                 135                 140                 


Arg Val Phe Gln Asp Cys Arg Asn Leu Asp Phe Leu Asp Leu Gly Tyr 
145                 150                 155                 160 


Asn Arg Leu Arg Ser Leu Ser Arg Asn Ala Phe Ala Gly Leu Leu Lys 
                165                 170                 175     


Leu Lys Glu Leu His Leu Glu His Asn Gln Phe Ser Lys Ile Asn Phe 
            180                 185                 190         


Ala His Phe Pro Arg Leu Phe Asn Leu Arg Ser Ile Tyr Leu Gln Trp 
        195                 200                 205             


Asn Arg Ile Arg Ser Ile Ser Gln Gly Leu Thr Trp Thr Trp Ser Ser 
    210                 215                 220                 


Leu His Asn Leu Asp Leu Ser Gly Asn Asp Ile Gln Gly Ile Glu Pro 
225                 230                 235                 240 


Gly Thr Phe Lys Cys Leu Pro Asn Leu Gln Lys Leu Asn Leu Asp Ser 
                245                 250                 255     


Asn Lys Leu Thr Asn Ile Ser Gln Glu Thr Val Asn Ala Trp Ile Ser 
            260                 265                 270         


Leu Ile Ser Ile Thr Leu Ser Gly Asn Met Trp Glu Cys Ser Arg Ser 
        275                 280                 285             


Ile Cys Pro Leu Phe Tyr Trp Leu Lys Asn Phe Lys Gly Asn Lys Glu 
    290                 295                 300                 


Ser Thr Met Ile Cys Ala Gly Pro Lys His Ile Gln Gly Glu Lys Val 
305                 310                 315                 320 


Ser Asp Ala Val Glu Thr Tyr Asn Ile Cys Ser Glu Val Gln Val Val 
                325                 330                 335     


Asn Thr Glu Arg Ser His Leu Val Pro Gln Thr Pro Gln Lys Pro Leu 
            340                 345                 350         


Ile Ile Pro Arg Pro Thr Ile Phe Lys Pro Asp Val Thr Gln Ser Thr 
        355                 360                 365             


Phe Glu Thr Pro Ser Pro Ser Pro Gly Phe Gln Ile Pro Gly Ala Glu 
    370                 375                 380                 


Gln Glu Tyr Glu His Val Ser Phe His Lys Ile Ile Ala Gly Ser Val 
385                 390                 395                 400 


Ala Leu Phe Leu Ser Val Ala Met Ile Leu Leu Val Ile Tyr Val Ser 
                405                 410                 415     


Trp Lys Arg Tyr Pro Ala Ser Met Lys Gln Leu Gln Gln His Ser Leu 
            420                 425                 430         


Met Lys Arg Arg Arg Lys Lys Ala Arg Glu Ser Glu Arg Gln Met Asn 
        435                 440                 445             


Ser Pro Leu Gln Glu Tyr Tyr Val Asp Tyr Lys Pro Thr Asn Ser Glu 
    450                 455                 460                 


Thr Met Asp Ile Ser Val Asn Gly Ser Gly Pro Cys Thr Tyr Thr Ile 
465                 470                 475                 480 


Ser Gly Ser Arg Glu Cys Glu Met Pro His His Met Lys Pro Leu Pro 
                485                 490                 495     


Tyr Tyr Ser Tyr Asp Gln Pro Val Ile Gly Tyr Cys Gln Ala His Gln 
            500                 505                 510         


Pro Leu His Val Thr Lys Gly Tyr Glu Thr Val Ser Pro Glu Gln Asp 
        515                 520                 525             


Glu Ser Pro Gly Leu Glu Leu Gly Arg Asp His Ser Phe Ile Ala Thr 
    530                 535                 540                 


Ile Ala Arg Ser Ala Ala Pro Ala Ile Tyr Leu Glu Arg Ile Ala Asn 
545                 550                 555                 560 


<210> 20
<211> 895
<212> PRT
<213> Homo sapiens

<400> 20
Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Trp Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser 
            100                 105                 110         


Gln Ser His Thr Leu Glu Gly Leu Pro Leu Asp Thr Asp Lys Gly Val 
        115                 120                 125             


His Tyr Ile Ser Val Ser Ala Thr Arg Leu Gly Ala Asn Gly Ser His 
    130                 135                 140                 


Ile Pro Gln Thr Ser Ser Val Phe Ser Ile Glu Val Tyr Pro Glu Asp 
145                 150                 155                 160 


His Ser Asp Leu Gln Ser Val Arg Thr Ala Ser Pro Asp Pro Gly Glu 
                165                 170                 175     


Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro Val Thr Val Leu Thr 
            180                 185                 190         


Val Ile Leu Asp Ala Asp Leu Thr Lys Met Thr Pro Lys Gln Arg Ile 
        195                 200                 205             


Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu Val Glu Leu His Asn 
    210                 215                 220                 


Met Lys Leu Val Pro Val Val Asn Asn Arg Leu Phe Asp Met Ser Ala 
225                 230                 235                 240 


Phe Met Ala Gly Pro Gly Asn Pro Lys Lys Val Val Glu Asn Gly Ala 
                245                 250                 255     


Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn Gln Asn Ser Val Pro 
            260                 265                 270         


Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu Gly Ala Met Ser Ala 
        275                 280                 285             


Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile Ala Asn Lys Lys Pro 
    290                 295                 300                 


Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His Ala Thr Pro Thr Pro 
305                 310                 315                 320 


Val Thr Ala Ile Gly Pro Pro Thr Thr Ala Ile Gln Glu Pro Pro Ser 
                325                 330                 335     


Arg Ile Val Pro Thr Pro Thr Ser Pro Ala Ile Ala Pro Pro Thr Glu 
            340                 345                 350         


Thr Met Ala Pro Pro Val Arg Asp Pro Val Pro Gly Lys Pro Thr Val 
        355                 360                 365             


Thr Ile Arg Thr Arg Gly Ala Ile Ile Gln Thr Pro Thr Leu Gly Pro 
    370                 375                 380                 


Ile Gln Pro Thr Arg Val Ser Glu Ala Gly Thr Thr Val Pro Gly Gln 
385                 390                 395                 400 


Ile Arg Pro Thr Met Thr Ile Pro Gly Tyr Val Glu Pro Thr Ala Val 
                405                 410                 415     


Ala Thr Pro Pro Thr Thr Thr Thr Lys Lys Pro Arg Val Ser Thr Pro 
            420                 425                 430         


Lys Pro Ala Thr Pro Ser Thr Asp Ser Thr Thr Thr Thr Thr Arg Arg 
        435                 440                 445             


Pro Thr Lys Lys Pro Arg Thr Pro Arg Pro Val Pro Arg Val Thr Thr 
    450                 455                 460                 


Lys Val Ser Ile Thr Arg Leu Glu Thr Ala Ser Pro Pro Thr Arg Ile 
465                 470                 475                 480 


Arg Thr Thr Thr Ser Gly Val Pro Arg Gly Gly Glu Pro Asn Gln Arg 
                485                 490                 495     


Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp Ala Trp Val Gly Thr 
            500                 505                 510         


Tyr Phe Glu Val Lys Ile Pro Ser Asp Thr Phe Tyr Asp His Glu Asp 
        515                 520                 525             


Thr Thr Thr Asp Lys Leu Lys Leu Thr Leu Lys Leu Arg Glu Gln Gln 
    530                 535                 540                 


Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn Ser Asn Ser Gln Leu 
545                 550                 555                 560 


Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly Lys His Glu Tyr Phe 
                565                 570                 575     


Met His Ala Thr Asp Lys Gly Gly Leu Ser Ala Val Asp Ala Phe Glu 
            580                 585                 590         


Ile His Val His Arg Arg Pro Gln Gly Asp Arg Ala Pro Ala Arg Phe 
        595                 600                 605             


Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val Leu Asn Asp Ile His 
    610                 615                 620                 


Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe Ala Phe Gly Asp Arg 
625                 630                 635                 640 


Asn Cys Ser Thr Ile Thr Leu Gln Asn Ile Thr Arg Gly Ser Ile Val 
                645                 650                 655     


Val Glu Trp Thr Asn Asn Thr Leu Pro Leu Glu Pro Cys Pro Lys Glu 
            660                 665                 670         


Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu Asp Asp Gly Lys Pro 
        675                 680                 685             


Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp Phe Lys Ala Thr Ser 
    690                 695                 700                 


Ile Thr Val Thr Gly Ser Gly Ser Cys Arg His Leu Gln Phe Ile Pro 
705                 710                 715                 720 


Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala Pro Pro Thr Glu Val 
                725                 730                 735     


Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp Asp Val Tyr Leu His 
            740                 745                 750         


Thr Val Ile Pro Ala Val Val Val Ala Ala Ile Leu Leu Ile Ala Gly 
        755                 760                 765             


Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg Lys Gly Lys Leu Thr 
    770                 775                 780                 


Leu Glu Asp Gln Ala Thr Phe Ile Lys Lys Gly Val Pro Ile Ile Phe 
785                 790                 795                 800 


Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro Ser Ser Ser Met Pro 
                805                 810                 815     


Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro Pro Pro Glu Tyr Pro 
            820                 825                 830         


Asn Gln Ser Val Pro Glu Thr Thr Pro Leu Asn Gln Asp Thr Met Gly 
        835                 840                 845             


Glu Tyr Thr Pro Leu Arg Asp Glu Asp Pro Asn Ala Pro Pro Tyr Gln 
    850                 855                 860                 


Pro Pro Pro Pro Phe Thr Val Pro Met Glu Gly Lys Gly Ser Arg Pro 
865                 870                 875                 880 


Lys Asn Met Thr Pro Tyr Arg Ser Pro Pro Pro Tyr Val Pro Pro 
                885                 890                 895 


<210> 21
<211> 868
<212> PRT
<213> Homo sapiens

<400> 21
Gln Ser His Trp Pro Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu 
1               5                   10                  15      


Asn Gln Leu Glu Ala Ser Met His Ser Val Leu Ser Asp Leu His Glu 
            20                  25                  30          


Ala Val Pro Thr Val Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly 
        35                  40                  45              


Arg Ser Phe Arg Val Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly 
    50                  55                  60                  


Asp Ile Ile Lys Val Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp 
65                  70                  75                  80  


Leu His Trp Asp Ser Gln Ser His Thr Leu Glu Gly Leu Pro Leu Asp 
                85                  90                  95      


Thr Asp Lys Gly Val His Tyr Ile Ser Val Ser Ala Thr Arg Leu Gly 
            100                 105                 110         


Ala Asn Gly Ser His Ile Pro Gln Thr Ser Ser Val Phe Ser Ile Glu 
        115                 120                 125             


Val Tyr Pro Glu Asp His Ser Asp Leu Gln Ser Val Arg Thr Ala Ser 
    130                 135                 140                 


Pro Asp Pro Gly Glu Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro 
145                 150                 155                 160 


Val Thr Val Leu Thr Val Ile Leu Asp Ala Asp Leu Thr Lys Met Thr 
                165                 170                 175     


Pro Lys Gln Arg Ile Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu 
            180                 185                 190         


Val Glu Leu His Asn Met Lys Leu Val Pro Val Val Asn Asn Arg Leu 
        195                 200                 205             


Phe Asp Met Ser Ala Phe Met Ala Gly Pro Gly Asn Pro Lys Lys Val 
    210                 215                 220                 


Val Glu Asn Gly Ala Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn 
225                 230                 235                 240 


Gln Asn Ser Val Pro Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu 
                245                 250                 255     


Gly Ala Met Ser Ala Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile 
            260                 265                 270         


Ala Asn Lys Lys Pro Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His 
        275                 280                 285             


Ala Thr Pro Thr Pro Val Thr Ala Ile Gly Pro Pro Thr Thr Ala Ile 
    290                 295                 300                 


Gln Glu Pro Pro Ser Arg Ile Val Pro Thr Pro Thr Ser Pro Ala Ile 
305                 310                 315                 320 


Ala Pro Pro Thr Glu Thr Met Ala Pro Pro Val Arg Asp Pro Val Pro 
                325                 330                 335     


Gly Lys Pro Thr Val Thr Ile Arg Thr Arg Gly Ala Ile Ile Gln Thr 
            340                 345                 350         


Pro Thr Leu Gly Pro Ile Gln Pro Thr Arg Val Ser Glu Ala Gly Thr 
        355                 360                 365             


Thr Val Pro Gly Gln Ile Arg Pro Thr Met Thr Ile Pro Gly Tyr Val 
    370                 375                 380                 


Glu Pro Thr Ala Val Ala Thr Pro Pro Thr Thr Thr Thr Lys Lys Pro 
385                 390                 395                 400 


Arg Val Ser Thr Pro Lys Pro Ala Thr Pro Ser Thr Asp Ser Thr Thr 
                405                 410                 415     


Thr Thr Thr Arg Arg Pro Thr Lys Lys Pro Arg Thr Pro Arg Pro Val 
            420                 425                 430         


Pro Arg Val Thr Thr Lys Val Ser Ile Thr Arg Leu Glu Thr Ala Ser 
        435                 440                 445             


Pro Pro Thr Arg Ile Arg Thr Thr Thr Ser Gly Val Pro Arg Gly Gly 
    450                 455                 460                 


Glu Pro Asn Gln Arg Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp 
465                 470                 475                 480 


Ala Trp Val Gly Thr Tyr Phe Glu Val Lys Ile Pro Ser Asp Thr Phe 
                485                 490                 495     


Tyr Asp His Glu Asp Thr Thr Thr Asp Lys Leu Lys Leu Thr Leu Lys 
            500                 505                 510         


Leu Arg Glu Gln Gln Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn 
        515                 520                 525             


Ser Asn Ser Gln Leu Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly 
    530                 535                 540                 


Lys His Glu Tyr Phe Met His Ala Thr Asp Lys Gly Gly Leu Ser Ala 
545                 550                 555                 560 


Val Asp Ala Phe Glu Ile His Val His Arg Arg Pro Gln Gly Asp Arg 
                565                 570                 575     


Ala Pro Ala Arg Phe Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val 
            580                 585                 590         


Leu Asn Asp Ile His Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe 
        595                 600                 605             


Ala Phe Gly Asp Arg Asn Cys Ser Thr Ile Thr Leu Gln Asn Ile Thr 
    610                 615                 620                 


Arg Gly Ser Ile Val Val Glu Trp Thr Asn Asn Thr Leu Pro Leu Glu 
625                 630                 635                 640 


Pro Cys Pro Lys Glu Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu 
                645                 650                 655     


Asp Asp Gly Lys Pro Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp 
            660                 665                 670         


Phe Lys Ala Thr Ser Ile Thr Val Thr Gly Ser Gly Ser Cys Arg His 
        675                 680                 685             


Leu Gln Phe Ile Pro Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala 
    690                 695                 700                 


Pro Pro Thr Glu Val Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp 
705                 710                 715                 720 


Asp Val Tyr Leu His Thr Val Ile Pro Ala Val Val Val Ala Ala Ile 
                725                 730                 735     


Leu Leu Ile Ala Gly Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg 
            740                 745                 750         


Lys Gly Lys Leu Thr Leu Glu Asp Gln Ala Thr Phe Ile Lys Lys Gly 
        755                 760                 765             


Val Pro Ile Ile Phe Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro 
    770                 775                 780                 


Ser Ser Ser Met Pro Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro 
785                 790                 795                 800 


Pro Pro Glu Tyr Pro Asn Gln Ser Val Pro Glu Thr Thr Pro Leu Asn 
                805                 810                 815     


Gln Asp Thr Met Gly Glu Tyr Thr Pro Leu Arg Asp Glu Asp Pro Asn 
            820                 825                 830         


Ala Pro Pro Tyr Gln Pro Pro Pro Pro Phe Thr Val Pro Met Glu Gly 
        835                 840                 845             


Lys Gly Ser Arg Pro Lys Asn Met Thr Pro Tyr Arg Ser Pro Pro Pro 
    850                 855                 860                 


Tyr Val Pro Pro 
865             


<210> 22
<211> 650
<212> PRT
<213> Homo sapiens

<400> 22
Met Gly Pro Ala Ser Pro Ala Ala Arg Gly Leu Ser Arg Arg Pro Gly 
1               5                   10                  15      


Gln Pro Pro Leu Pro Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Arg 
            20                  25                  30          


Ala Gln Pro Ala Ile Gly Ser Leu Ala Gly Gly Ser Pro Gly Ala Ala 
        35                  40                  45              


Glu Ala Pro Gly Ser Ala Gln Val Ala Gly Leu Cys Gly Arg Leu Thr 
    50                  55                  60                  


Leu His Arg Asp Leu Arg Thr Gly Arg Trp Glu Pro Asp Pro Gln Arg 
65                  70                  75                  80  


Ser Arg Arg Cys Leu Arg Asp Pro Gln Arg Val Leu Glu Tyr Cys Arg 
                85                  90                  95      


Gln Met Tyr Pro Glu Leu Gln Ile Ala Arg Val Glu Gln Ala Thr Gln 
            100                 105                 110         


Ala Ile Pro Met Glu Arg Trp Cys Gly Gly Ser Arg Ser Gly Ser Cys 
        115                 120                 125             


Ala His Pro His His Gln Val Val Pro Phe Arg Cys Leu Pro Gly Glu 
    130                 135                 140                 


Phe Val Ser Glu Ala Leu Leu Val Pro Glu Gly Cys Arg Phe Leu His 
145                 150                 155                 160 


Gln Glu Arg Met Asp Gln Cys Glu Ser Ser Thr Arg Arg His Gln Glu 
                165                 170                 175     


Ala Gln Glu Ala Cys Ser Ser Gln Gly Leu Ile Leu His Gly Ser Gly 
            180                 185                 190         


Met Leu Leu Pro Cys Gly Ser Asp Arg Phe Arg Gly Val Glu Tyr Val 
        195                 200                 205             


Cys Cys Pro Pro Pro Gly Thr Pro Asp Pro Ser Gly Thr Ala Val Gly 
    210                 215                 220                 


Asp Pro Ser Thr Arg Ser Trp Pro Pro Gly Ser Arg Val Glu Gly Ala 
225                 230                 235                 240 


Glu Asp Glu Glu Glu Glu Glu Ser Phe Pro Gln Pro Val Asp Asp Tyr 
                245                 250                 255     


Phe Val Glu Pro Pro Gln Ala Glu Glu Glu Glu Glu Thr Val Pro Pro 
            260                 265                 270         


Pro Ser Ser His Thr Leu Ala Val Val Gly Lys Val Thr Pro Thr Pro 
        275                 280                 285             


Arg Pro Thr Asp Gly Val Asp Ile Tyr Phe Gly Met Pro Gly Glu Ile 
    290                 295                 300                 


Ser Glu His Glu Gly Phe Leu Arg Ala Lys Met Asp Leu Glu Glu Arg 
305                 310                 315                 320 


Arg Met Arg Gln Ile Asn Glu Val Met Arg Glu Trp Ala Met Ala Asp 
                325                 330                 335     


Asn Gln Ser Lys Asn Leu Pro Lys Ala Asp Arg Gln Ala Leu Asn Glu 
            340                 345                 350         


His Phe Gln Ser Ile Leu Gln Thr Leu Glu Glu Gln Val Ser Gly Glu 
        355                 360                 365             


Arg Gln Arg Leu Val Glu Thr His Ala Thr Arg Val Ile Ala Leu Ile 
    370                 375                 380                 


Asn Asp Gln Arg Arg Ala Ala Leu Glu Gly Phe Leu Ala Ala Leu Gln 
385                 390                 395                 400 


Ala Asp Pro Pro Gln Ala Glu Arg Val Leu Leu Ala Leu Arg Arg Tyr 
                405                 410                 415     


Leu Arg Ala Glu Gln Lys Glu Gln Arg His Thr Leu Arg His Tyr Gln 
            420                 425                 430         


His Val Ala Ala Val Asp Pro Glu Lys Ala Gln Gln Met Arg Phe Gln 
        435                 440                 445             


Val His Thr His Leu Gln Val Ile Glu Glu Arg Val Asn Gln Ser Leu 
    450                 455                 460                 


Gly Leu Leu Asp Gln Asn Pro His Leu Ala Gln Glu Leu Arg Pro Gln 
465                 470                 475                 480 


Ile Gln Glu Leu Leu His Ser Glu His Leu Gly Pro Ser Glu Leu Glu 
                485                 490                 495     


Ala Pro Ala Pro Gly Gly Ser Ser Glu Asp Lys Gly Gly Leu Gln Pro 
            500                 505                 510         


Pro Asp Ser Lys Asp Asp Thr Pro Met Thr Leu Pro Lys Gly Ser Thr 
        515                 520                 525             


Glu Gln Asp Ala Ala Ser Pro Glu Lys Glu Lys Met Asn Pro Leu Glu 
    530                 535                 540                 


Gln Tyr Glu Arg Lys Val Asn Ala Ser Val Pro Arg Gly Phe Pro Phe 
545                 550                 555                 560 


His Ser Ser Glu Ile Gln Arg Asp Glu Leu Ala Pro Ala Gly Thr Gly 
                565                 570                 575     


Val Ser Arg Glu Ala Val Ser Gly Leu Leu Ile Met Gly Ala Gly Gly 
            580                 585                 590         


Gly Ser Leu Ile Val Leu Ser Met Leu Leu Leu Arg Arg Lys Lys Pro 
        595                 600                 605             


Tyr Gly Ala Ile Ser His Gly Val Val Glu Val Asp Pro Met Leu Thr 
    610                 615                 620                 


Leu Glu Glu Gln Gln Leu Arg Glu Leu Gln Arg His Gly Tyr Glu Asn 
625                 630                 635                 640 


Pro Thr Tyr Arg Phe Leu Glu Glu Arg Pro 
                645                 650 


<210> 23
<211> 612
<212> PRT
<213> Homo sapiens

<400> 23
Ser Leu Ala Gly Gly Ser Pro Gly Ala Ala Glu Ala Pro Gly Ser Ala 
1               5                   10                  15      


Gln Val Ala Gly Leu Cys Gly Arg Leu Thr Leu His Arg Asp Leu Arg 
            20                  25                  30          


Thr Gly Arg Trp Glu Pro Asp Pro Gln Arg Ser Arg Arg Cys Leu Arg 
        35                  40                  45              


Asp Pro Gln Arg Val Leu Glu Tyr Cys Arg Gln Met Tyr Pro Glu Leu 
    50                  55                  60                  


Gln Ile Ala Arg Val Glu Gln Ala Thr Gln Ala Ile Pro Met Glu Arg 
65                  70                  75                  80  


Trp Cys Gly Gly Ser Arg Ser Gly Ser Cys Ala His Pro His His Gln 
                85                  90                  95      


Val Val Pro Phe Arg Cys Leu Pro Gly Glu Phe Val Ser Glu Ala Leu 
            100                 105                 110         


Leu Val Pro Glu Gly Cys Arg Phe Leu His Gln Glu Arg Met Asp Gln 
        115                 120                 125             


Cys Glu Ser Ser Thr Arg Arg His Gln Glu Ala Gln Glu Ala Cys Ser 
    130                 135                 140                 


Ser Gln Gly Leu Ile Leu His Gly Ser Gly Met Leu Leu Pro Cys Gly 
145                 150                 155                 160 


Ser Asp Arg Phe Arg Gly Val Glu Tyr Val Cys Cys Pro Pro Pro Gly 
                165                 170                 175     


Thr Pro Asp Pro Ser Gly Thr Ala Val Gly Asp Pro Ser Thr Arg Ser 
            180                 185                 190         


Trp Pro Pro Gly Ser Arg Val Glu Gly Ala Glu Asp Glu Glu Glu Glu 
        195                 200                 205             


Glu Ser Phe Pro Gln Pro Val Asp Asp Tyr Phe Val Glu Pro Pro Gln 
    210                 215                 220                 


Ala Glu Glu Glu Glu Glu Thr Val Pro Pro Pro Ser Ser His Thr Leu 
225                 230                 235                 240 


Ala Val Val Gly Lys Val Thr Pro Thr Pro Arg Pro Thr Asp Gly Val 
                245                 250                 255     


Asp Ile Tyr Phe Gly Met Pro Gly Glu Ile Ser Glu His Glu Gly Phe 
            260                 265                 270         


Leu Arg Ala Lys Met Asp Leu Glu Glu Arg Arg Met Arg Gln Ile Asn 
        275                 280                 285             


Glu Val Met Arg Glu Trp Ala Met Ala Asp Asn Gln Ser Lys Asn Leu 
    290                 295                 300                 


Pro Lys Ala Asp Arg Gln Ala Leu Asn Glu His Phe Gln Ser Ile Leu 
305                 310                 315                 320 


Gln Thr Leu Glu Glu Gln Val Ser Gly Glu Arg Gln Arg Leu Val Glu 
                325                 330                 335     


Thr His Ala Thr Arg Val Ile Ala Leu Ile Asn Asp Gln Arg Arg Ala 
            340                 345                 350         


Ala Leu Glu Gly Phe Leu Ala Ala Leu Gln Ala Asp Pro Pro Gln Ala 
        355                 360                 365             


Glu Arg Val Leu Leu Ala Leu Arg Arg Tyr Leu Arg Ala Glu Gln Lys 
    370                 375                 380                 


Glu Gln Arg His Thr Leu Arg His Tyr Gln His Val Ala Ala Val Asp 
385                 390                 395                 400 


Pro Glu Lys Ala Gln Gln Met Arg Phe Gln Val His Thr His Leu Gln 
                405                 410                 415     


Val Ile Glu Glu Arg Val Asn Gln Ser Leu Gly Leu Leu Asp Gln Asn 
            420                 425                 430         


Pro His Leu Ala Gln Glu Leu Arg Pro Gln Ile Gln Glu Leu Leu His 
        435                 440                 445             


Ser Glu His Leu Gly Pro Ser Glu Leu Glu Ala Pro Ala Pro Gly Gly 
    450                 455                 460                 


Ser Ser Glu Asp Lys Gly Gly Leu Gln Pro Pro Asp Ser Lys Asp Asp 
465                 470                 475                 480 


Thr Pro Met Thr Leu Pro Lys Gly Ser Thr Glu Gln Asp Ala Ala Ser 
                485                 490                 495     


Pro Glu Lys Glu Lys Met Asn Pro Leu Glu Gln Tyr Glu Arg Lys Val 
            500                 505                 510         


Asn Ala Ser Val Pro Arg Gly Phe Pro Phe His Ser Ser Glu Ile Gln 
        515                 520                 525             


Arg Asp Glu Leu Ala Pro Ala Gly Thr Gly Val Ser Arg Glu Ala Val 
    530                 535                 540                 


Ser Gly Leu Leu Ile Met Gly Ala Gly Gly Gly Ser Leu Ile Val Leu 
545                 550                 555                 560 


Ser Met Leu Leu Leu Arg Arg Lys Lys Pro Tyr Gly Ala Ile Ser His 
                565                 570                 575     


Gly Val Val Glu Val Asp Pro Met Leu Thr Leu Glu Glu Gln Gln Leu 
            580                 585                 590         


Arg Glu Leu Gln Arg His Gly Tyr Glu Asn Pro Thr Tyr Arg Phe Leu 
        595                 600                 605             


Glu Glu Arg Pro 
    610         


<210> 24
<211> 979
<212> PRT
<213> Homo sapiens

<400> 24
Met Arg Arg Pro Arg Arg Pro Gly Gly Leu Gly Gly Ser Gly Gly Leu 
1               5                   10                  15      


Arg Leu Leu Leu Cys Leu Leu Leu Leu Ser Ser Arg Pro Gly Gly Cys 
            20                  25                  30          


Ser Ala Val Ser Ala His Gly Cys Leu Phe Asp Arg Arg Leu Cys Ser 
        35                  40                  45              


His Leu Glu Val Cys Ile Gln Asp Gly Leu Phe Gly Gln Cys Gln Val 
    50                  55                  60                  


Gly Val Gly Gln Ala Arg Pro Leu Leu Gln Val Thr Ser Pro Val Leu 
65                  70                  75                  80  


Gln Arg Leu Gln Gly Val Leu Arg Gln Leu Met Ser Gln Gly Leu Ser 
                85                  90                  95      


Trp His Asp Asp Leu Thr Gln Tyr Val Ile Ser Gln Glu Met Glu Arg 
            100                 105                 110         


Ile Pro Arg Leu Arg Pro Pro Glu Pro Arg Pro Arg Asp Arg Ser Gly 
        115                 120                 125             


Leu Ala Pro Lys Arg Pro Gly Pro Ala Gly Glu Leu Leu Leu Gln Asp 
    130                 135                 140                 


Ile Pro Thr Gly Ser Ala Pro Ala Ala Gln His Arg Leu Pro Gln Pro 
145                 150                 155                 160 


Pro Val Gly Lys Gly Gly Ala Gly Ala Ser Ser Ser Leu Ser Pro Leu 
                165                 170                 175     


Gln Ala Glu Leu Leu Pro Pro Leu Leu Glu His Leu Leu Leu Pro Pro 
            180                 185                 190         


Gln Pro Pro His Pro Ser Leu Ser Tyr Glu Pro Ala Leu Leu Gln Pro 
        195                 200                 205             


Tyr Leu Phe His Gln Phe Gly Ser Arg Asp Gly Ser Arg Val Ser Glu 
    210                 215                 220                 


Gly Ser Pro Gly Met Val Ser Val Gly Pro Leu Pro Lys Ala Glu Ala 
225                 230                 235                 240 


Pro Ala Leu Phe Ser Arg Thr Ala Ser Lys Gly Ile Phe Gly Asp His 
                245                 250                 255     


Pro Gly His Ser Tyr Gly Asp Leu Pro Gly Pro Ser Pro Ala Gln Leu 
            260                 265                 270         


Phe Gln Asp Ser Gly Leu Leu Tyr Leu Ala Gln Glu Leu Pro Ala Pro 
        275                 280                 285             


Ser Arg Ala Arg Val Pro Arg Leu Pro Glu Gln Gly Ser Ser Ser Arg 
    290                 295                 300                 


Ala Glu Asp Ser Pro Glu Gly Tyr Glu Lys Glu Gly Leu Gly Asp Arg 
305                 310                 315                 320 


Gly Glu Lys Pro Ala Ser Pro Ala Val Gln Pro Asp Ala Ala Leu Gln 
                325                 330                 335     


Arg Leu Ala Ala Val Leu Ala Gly Tyr Gly Val Glu Leu Arg Gln Leu 
            340                 345                 350         


Thr Pro Glu Gln Leu Ser Thr Leu Leu Thr Leu Leu Gln Leu Leu Pro 
        355                 360                 365             


Lys Gly Ala Gly Arg Asn Pro Gly Gly Val Val Asn Val Gly Ala Asp 
    370                 375                 380                 


Ile Lys Lys Thr Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu 
385                 390                 395                 400 


Leu Pro Ala Arg Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro 
                405                 410                 415     


Thr Ser Ser Glu Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro 
            420                 425                 430         


Pro Lys Ala Ala Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys 
        435                 440                 445             


Ser Pro Leu Gly Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala 
    450                 455                 460                 


Arg Pro Ala Ala Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro 
465                 470                 475                 480 


Leu Ser Leu Ala Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His 
                485                 490                 495     


Val His Met Ser Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro 
            500                 505                 510         


Ala Leu Thr Phe Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala 
        515                 520                 525             


Asp Val Thr Gln Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln 
    530                 535                 540                 


Thr Gly Leu Gln Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala 
545                 550                 555                 560 


Ala Ala Val Leu Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser 
                565                 570                 575     


Val Leu Leu Thr Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val 
            580                 585                 590         


Ala Leu Ala Val Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp 
        595                 600                 605             


Lys Glu Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr 
    610                 615                 620                 


Thr Phe Glu Tyr Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser 
625                 630                 635                 640 


Leu Phe Asn Arg Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser 
                645                 650                 655     


Val Ser Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His 
            660                 665                 670         


Ser Ser Thr Pro Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp 
        675                 680                 685             


Ile Ser Thr Gly His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg 
    690                 695                 700                 


Asn Arg Asp Arg Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln 
705                 710                 715                 720 


Ala Glu Pro Asn Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys 
                725                 730                 735     


Lys Asn Arg His Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys 
            740                 745                 750         


Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser 
        755                 760                 765             


Pro Ile Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln 
    770                 775                 780                 


Gly Pro Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu 
785                 790                 795                 800 


Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly 
                805                 810                 815     


Val Lys Gln Cys Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr 
            820                 825                 830         


His Val Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp 
        835                 840                 845             


Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr 
    850                 855                 860                 


Arg Thr Leu Thr Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr 
865                 870                 875                 880 


Pro Ala Ser Thr Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys 
                885                 890                 895     


Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly 
            900                 905                 910         


Ala Gly Arg Thr Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg 
        915                 920                 925             


Met Ala Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His 
    930                 935                 940                 


Val Arg Asp Gln Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu 
945                 950                 955                 960 


Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala 
                965                 970                 975     


Leu Pro Gln 
            


<210> 25
<211> 945
<212> PRT
<213> Homo sapiens

<400> 25
Val Ser Ala His Gly Cys Leu Phe Asp Arg Arg Leu Cys Ser His Leu 
1               5                   10                  15      


Glu Val Cys Ile Gln Asp Gly Leu Phe Gly Gln Cys Gln Val Gly Val 
            20                  25                  30          


Gly Gln Ala Arg Pro Leu Leu Gln Val Thr Ser Pro Val Leu Gln Arg 
        35                  40                  45              


Leu Gln Gly Val Leu Arg Gln Leu Met Ser Gln Gly Leu Ser Trp His 
    50                  55                  60                  


Asp Asp Leu Thr Gln Tyr Val Ile Ser Gln Glu Met Glu Arg Ile Pro 
65                  70                  75                  80  


Arg Leu Arg Pro Pro Glu Pro Arg Pro Arg Asp Arg Ser Gly Leu Ala 
                85                  90                  95      


Pro Lys Arg Pro Gly Pro Ala Gly Glu Leu Leu Leu Gln Asp Ile Pro 
            100                 105                 110         


Thr Gly Ser Ala Pro Ala Ala Gln His Arg Leu Pro Gln Pro Pro Val 
        115                 120                 125             


Gly Lys Gly Gly Ala Gly Ala Ser Ser Ser Leu Ser Pro Leu Gln Ala 
    130                 135                 140                 


Glu Leu Leu Pro Pro Leu Leu Glu His Leu Leu Leu Pro Pro Gln Pro 
145                 150                 155                 160 


Pro His Pro Ser Leu Ser Tyr Glu Pro Ala Leu Leu Gln Pro Tyr Leu 
                165                 170                 175     


Phe His Gln Phe Gly Ser Arg Asp Gly Ser Arg Val Ser Glu Gly Ser 
            180                 185                 190         


Pro Gly Met Val Ser Val Gly Pro Leu Pro Lys Ala Glu Ala Pro Ala 
        195                 200                 205             


Leu Phe Ser Arg Thr Ala Ser Lys Gly Ile Phe Gly Asp His Pro Gly 
    210                 215                 220                 


His Ser Tyr Gly Asp Leu Pro Gly Pro Ser Pro Ala Gln Leu Phe Gln 
225                 230                 235                 240 


Asp Ser Gly Leu Leu Tyr Leu Ala Gln Glu Leu Pro Ala Pro Ser Arg 
                245                 250                 255     


Ala Arg Val Pro Arg Leu Pro Glu Gln Gly Ser Ser Ser Arg Ala Glu 
            260                 265                 270         


Asp Ser Pro Glu Gly Tyr Glu Lys Glu Gly Leu Gly Asp Arg Gly Glu 
        275                 280                 285             


Lys Pro Ala Ser Pro Ala Val Gln Pro Asp Ala Ala Leu Gln Arg Leu 
    290                 295                 300                 


Ala Ala Val Leu Ala Gly Tyr Gly Val Glu Leu Arg Gln Leu Thr Pro 
305                 310                 315                 320 


Glu Gln Leu Ser Thr Leu Leu Thr Leu Leu Gln Leu Leu Pro Lys Gly 
                325                 330                 335     


Ala Gly Arg Asn Pro Gly Gly Val Val Asn Val Gly Ala Asp Ile Lys 
            340                 345                 350         


Lys Thr Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu Leu Pro 
        355                 360                 365             


Ala Arg Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro Thr Ser 
    370                 375                 380                 


Ser Glu Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro Pro Lys 
385                 390                 395                 400 


Ala Ala Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys Ser Pro 
                405                 410                 415     


Leu Gly Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala Arg Pro 
            420                 425                 430         


Ala Ala Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro Leu Ser 
        435                 440                 445             


Leu Ala Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His Val His 
    450                 455                 460                 


Met Ser Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro Ala Leu 
465                 470                 475                 480 


Thr Phe Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala Asp Val 
                485                 490                 495     


Thr Gln Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln Thr Gly 
            500                 505                 510         


Leu Gln Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala Ala Ala 
        515                 520                 525             


Val Leu Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser Val Leu 
    530                 535                 540                 


Leu Thr Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val Ala Leu 
545                 550                 555                 560 


Ala Val Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp Lys Glu 
                565                 570                 575     


Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr Thr Phe 
            580                 585                 590         


Glu Tyr Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser Leu Phe 
        595                 600                 605             


Asn Arg Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser Val Ser 
    610                 615                 620                 


Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His Ser Ser 
625                 630                 635                 640 


Thr Pro Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp Ile Ser 
                645                 650                 655     


Thr Gly His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg Asn Arg 
            660                 665                 670         


Asp Arg Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln Ala Glu 
        675                 680                 685             


Pro Asn Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys Lys Asn 
    690                 695                 700                 


Arg His Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys Leu Lys 
705                 710                 715                 720 


Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser Pro Ile 
                725                 730                 735     


Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln Gly Pro 
            740                 745                 750         


Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu Ser Gly 
        755                 760                 765             


Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly Val Lys 
    770                 775                 780                 


Gln Cys Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr His Val 
785                 790                 795                 800 


Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp Phe Leu 
                805                 810                 815     


Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr Arg Thr 
            820                 825                 830         


Leu Thr Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr Pro Ala 
        835                 840                 845             


Ser Thr Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys Cys Tyr 
    850                 855                 860                 


Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly Ala Gly 
865                 870                 875                 880 


Arg Thr Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg Met Ala 
                885                 890                 895     


Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His Val Arg 
            900                 905                 910         


Asp Gln Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu Phe Ala 
        915                 920                 925             


Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala Leu Pro 
    930                 935                 940                 


Gln 
945 


<210> 26
<211> 366
<212> PRT
<213> Homo sapiens

<400> 26
Met Leu Leu Leu Arg Cys Gln Leu Lys Gln Ala Pro Pro Gln Lys Val 
1               5                   10                  15      


Ser Phe Arg Phe Cys Val Val Met Gly Lys Gln Gln Ser Lys Leu Lys 
            20                  25                  30          


His Ser Thr Tyr Lys Tyr Gly Pro Asp Glu Ile Ile Glu Glu Arg Ile 
        35                  40                  45              


Gln Thr Lys Ala Phe Gln Glu Tyr Ser Pro Ala His Met Asp Thr Val 
    50                  55                  60                  


Ser Val Val Ala Ala Leu Asn Ser Asp Leu Cys Val Ser Gly Gly Lys 
65                  70                  75                  80  


Asp Lys Thr Val Val Ala Tyr Asn Trp Lys Thr Gly Asn Val Val Lys 
                85                  90                  95      


Arg Phe Lys Gly His Glu His Glu Ile Thr Lys Val Ala Cys Ile Pro 
            100                 105                 110         


Lys Ser Ser Gln Phe Phe Ser Ala Ser Arg Asp Arg Met Val Met Met 
        115                 120                 125             


Trp Asp Leu His Gly Ser Ser Gln Pro Arg Gln Gln Leu Cys Gly His 
    130                 135                 140                 


Ala Met Val Val Thr Gly Leu Ala Val Ser Pro Asp Ser Ser Gln Leu 
145                 150                 155                 160 


Cys Thr Gly Ser Arg Asp Asn Thr Leu Leu Leu Trp Asp Val Val Thr 
                165                 170                 175     


Gly Gln Ser Val Glu Arg Ala Ser Val Ser Arg Asn Val Val Thr His 
            180                 185                 190         


Leu Cys Trp Val Pro Arg Glu Pro Tyr Ile Leu Gln Thr Ser Glu Asp 
        195                 200                 205             


Lys Thr Leu Arg Leu Trp Asp Ser Arg Gly Leu Gln Val Ala His Met 
    210                 215                 220                 


Phe Pro Ala Lys Gln His Ile Gln Thr Tyr Cys Glu Val Ser Val Asp 
225                 230                 235                 240 


Gly His Lys Cys Ile Ser Cys Ser Asn Gly Phe Gly Gly Glu Gly Cys 
                245                 250                 255     


Glu Ala Thr Leu Trp Asp Leu Arg Gln Thr Arg Asn Arg Ile Cys Glu 
            260                 265                 270         


Tyr Lys Gly His Phe Gln Thr Val Ala Ser Cys Val Phe Leu Pro Arg 
        275                 280                 285             


Ala Leu Ala Leu Met Pro Leu Ile Ala Thr Ser Ser His Asp Cys Lys 
    290                 295                 300                 


Val Lys Ile Trp Asn Gln Asp Thr Gly Ala Cys Leu Phe Thr Leu Ser 
305                 310                 315                 320 


Leu Asp Gly Ser Gly Pro Leu Thr Ser Leu Ala Val Gly Asp Ala Ile 
                325                 330                 335     


Ser Leu Leu Cys Ala Ser Phe Asn Arg Gly Ile His Leu Leu Arg Met 
            340                 345                 350         


Asp His Ser Gln Gly Leu Glu Leu Gln Glu Val Ala Ala Phe 
        355                 360                 365     


<210> 27
<211> 343
<212> PRT
<213> Homo sapiens

<400> 27
Met Ala Gln Lys Gly Val Leu Gly Pro Gly Gln Leu Gly Ala Val Ala 
1               5                   10                  15      


Ile Leu Leu Tyr Leu Gly Leu Leu Arg Ser Gly Thr Gly Ala Glu Gly 
            20                  25                  30          


Ala Glu Ala Pro Cys Gly Val Ala Pro Gln Ala Arg Ile Thr Gly Gly 
        35                  40                  45              


Ser Ser Ala Val Ala Gly Gln Trp Pro Trp Gln Val Ser Ile Thr Tyr 
    50                  55                  60                  


Glu Gly Val His Val Cys Gly Gly Ser Leu Val Ser Glu Gln Trp Val 
65                  70                  75                  80  


Leu Ser Ala Ala His Cys Phe Pro Ser Glu His His Lys Glu Ala Tyr 
                85                  90                  95      


Glu Val Lys Leu Gly Ala His Gln Leu Asp Ser Tyr Ser Glu Asp Ala 
            100                 105                 110         


Lys Val Ser Thr Leu Lys Asp Ile Ile Pro His Pro Ser Tyr Leu Gln 
        115                 120                 125             


Glu Gly Ser Gln Gly Asp Ile Ala Leu Leu Gln Leu Ser Arg Pro Ile 
    130                 135                 140                 


Thr Phe Ser Arg Tyr Ile Arg Pro Ile Cys Leu Pro Ala Ala Asn Ala 
145                 150                 155                 160 


Ser Phe Pro Asn Gly Leu His Cys Thr Val Thr Gly Trp Gly His Val 
                165                 170                 175     


Ala Pro Ser Val Ser Leu Leu Thr Pro Lys Pro Leu Gln Gln Leu Glu 
            180                 185                 190         


Val Pro Leu Ile Ser Arg Glu Thr Cys Asn Cys Leu Tyr Asn Ile Asp 
        195                 200                 205             


Ala Lys Pro Glu Glu Pro His Phe Val Gln Glu Asp Met Val Cys Ala 
    210                 215                 220                 


Gly Tyr Val Glu Gly Gly Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly 
225                 230                 235                 240 


Pro Leu Ser Cys Pro Val Glu Gly Leu Trp Tyr Leu Thr Gly Ile Val 
                245                 250                 255     


Ser Trp Gly Asp Ala Cys Gly Ala Arg Asn Arg Pro Gly Val Tyr Thr 
            260                 265                 270         


Leu Ala Ser Ser Tyr Ala Ser Trp Ile Gln Ser Lys Val Thr Glu Leu 
        275                 280                 285             


Gln Pro Arg Val Val Pro Gln Thr Gln Glu Ser Gln Pro Asp Ser Asn 
    290                 295                 300                 


Leu Cys Gly Ser His Leu Ala Phe Ser Ser Ala Pro Ala Gln Gly Leu 
305                 310                 315                 320 


Leu Arg Pro Ile Leu Phe Leu Pro Leu Gly Leu Ala Leu Gly Leu Leu 
                325                 330                 335     


Ser Pro Trp Leu Ser Glu His 
            340             


<210> 28
<211> 311
<212> PRT
<213> Homo sapiens

<400> 28
Ala Glu Ala Pro Cys Gly Val Ala Pro Gln Ala Arg Ile Thr Gly Gly 
1               5                   10                  15      


Ser Ser Ala Val Ala Gly Gln Trp Pro Trp Gln Val Ser Ile Thr Tyr 
            20                  25                  30          


Glu Gly Val His Val Cys Gly Gly Ser Leu Val Ser Glu Gln Trp Val 
        35                  40                  45              


Leu Ser Ala Ala His Cys Phe Pro Ser Glu His His Lys Glu Ala Tyr 
    50                  55                  60                  


Glu Val Lys Leu Gly Ala His Gln Leu Asp Ser Tyr Ser Glu Asp Ala 
65                  70                  75                  80  


Lys Val Ser Thr Leu Lys Asp Ile Ile Pro His Pro Ser Tyr Leu Gln 
                85                  90                  95      


Glu Gly Ser Gln Gly Asp Ile Ala Leu Leu Gln Leu Ser Arg Pro Ile 
            100                 105                 110         


Thr Phe Ser Arg Tyr Ile Arg Pro Ile Cys Leu Pro Ala Ala Asn Ala 
        115                 120                 125             


Ser Phe Pro Asn Gly Leu His Cys Thr Val Thr Gly Trp Gly His Val 
    130                 135                 140                 


Ala Pro Ser Val Ser Leu Leu Thr Pro Lys Pro Leu Gln Gln Leu Glu 
145                 150                 155                 160 


Val Pro Leu Ile Ser Arg Glu Thr Cys Asn Cys Leu Tyr Asn Ile Asp 
                165                 170                 175     


Ala Lys Pro Glu Glu Pro His Phe Val Gln Glu Asp Met Val Cys Ala 
            180                 185                 190         


Gly Tyr Val Glu Gly Gly Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly 
        195                 200                 205             


Pro Leu Ser Cys Pro Val Glu Gly Leu Trp Tyr Leu Thr Gly Ile Val 
    210                 215                 220                 


Ser Trp Gly Asp Ala Cys Gly Ala Arg Asn Arg Pro Gly Val Tyr Thr 
225                 230                 235                 240 


Leu Ala Ser Ser Tyr Ala Ser Trp Ile Gln Ser Lys Val Thr Glu Leu 
                245                 250                 255     


Gln Pro Arg Val Val Pro Gln Thr Gln Glu Ser Gln Pro Asp Ser Asn 
            260                 265                 270         


Leu Cys Gly Ser His Leu Ala Phe Ser Ser Ala Pro Ala Gln Gly Leu 
        275                 280                 285             


Leu Arg Pro Ile Leu Phe Leu Pro Leu Gly Leu Ala Leu Gly Leu Leu 
    290                 295                 300                 


Ser Pro Trp Leu Ser Glu His 
305                 310     


<210> 29
<211> 316
<212> PRT
<213> Homo sapiens

<400> 29
Met Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Val 
1               5                   10                  15      


Glu Gly Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser 
            20                  25                  30          


Ser Val Thr Val Gln Glu Gly Met Cys Ala His Val Arg Cys Ser Phe 
        35                  40                  45              


Ser Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr 
    50                  55                  60                  


Trp Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr 
65                  70                  75                  80  


Asn Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His 
                85                  90                  95      


Leu Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp 
            100                 105                 110         


Ala Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly 
        115                 120                 125             


Asn Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr 
    130                 135                 140                 


Asp Pro Pro Gln Asn Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr 
145                 150                 155                 160 


Ala Ser Thr Ala Leu Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly 
                165                 170                 175     


Gln Ser Leu Arg Leu Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg 
            180                 185                 190         


Leu Ser Trp Thr Trp Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser 
        195                 200                 205             


Asn Pro Leu Val Leu Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu 
    210                 215                 220                 


Phe Thr Cys Arg Ala Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu 
225                 230                 235                 240 


Asn Leu Ser Leu Gln Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser 
                245                 250                 255     


Gly Val Leu Leu Gly Ala Val Gly Gly Ala Gly Ala Thr Ala Leu Val 
            260                 265                 270         


Phe Leu Ser Phe Cys Val Ile Phe Ile Val Val Arg Ser Cys Arg Lys 
        275                 280                 285             


Lys Ser Ala Arg Pro Ala Ala Asp Val Gly Asp Ile Gly Met Lys Asp 
    290                 295                 300                 


Ala Asn Thr Ile Arg Gly Ser Ala Leu Arg Val Thr 
305                 310                 315     


<210> 30
<211> 298
<212> PRT
<213> Homo sapiens

<400> 30
Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser Ser Val 
1               5                   10                  15      


Thr Val Gln Glu Gly Met Cys Ala His Val Arg Cys Ser Phe Ser Tyr 
            20                  25                  30          


Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr Trp Phe 
        35                  40                  45              


Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr Asn Asn 
    50                  55                  60                  


Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu Leu 
65                  70                  75                  80  


Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg 
                85                  90                  95      


Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Asn Ile 
            100                 105                 110         


Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Asp Pro 
        115                 120                 125             


Pro Gln Asn Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser 
    130                 135                 140                 


Thr Ala Leu Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser 
145                 150                 155                 160 


Leu Arg Leu Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser 
                165                 170                 175     


Trp Thr Trp Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro 
            180                 185                 190         


Leu Val Leu Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr 
        195                 200                 205             


Cys Arg Ala Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu 
    210                 215                 220                 


Ser Leu Gln Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val 
225                 230                 235                 240 


Leu Leu Gly Ala Val Gly Gly Ala Gly Ala Thr Ala Leu Val Phe Leu 
                245                 250                 255     


Ser Phe Cys Val Ile Phe Ile Val Val Arg Ser Cys Arg Lys Lys Ser 
            260                 265                 270         


Ala Arg Pro Ala Ala Asp Val Gly Asp Ile Gly Met Lys Asp Ala Asn 
        275                 280                 285             


Thr Ile Arg Gly Ser Ala Leu Arg Val Thr 
    290                 295             


<210> 31
<211> 267
<212> PRT
<213> Homo sapiens

<400> 31
Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
225                 230                 235                 240 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                245                 250                 255     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265         


<210> 32
<211> 237
<212> PRT
<213> Homo sapiens

<400> 32
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val 
                165                 170                 175     


Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser 
            180                 185                 190         


Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser 
        195                 200                 205             


Val Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser 
    210                 215                 220                 


Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
225                 230                 235         


<210> 33
<211> 224
<212> PRT
<213> Mus sp.

<400> 33
Met Ala Leu Leu Ile Ser Leu Pro Gly Gly Thr Pro Ala Met Ala Gln 
1               5                   10                  15      


Val Leu Leu Leu Leu Ser Ser Gly Cys Leu His Ala Gly Asn Ser Glu 
            20                  25                  30          


Arg Tyr Asn Arg Lys Asn Gly Phe Gly Val Asn Gln Pro Glu Arg Cys 
        35                  40                  45              


Ser Gly Val Gln Gly Gly Ser Ile Asp Ile Pro Phe Ser Phe Tyr Phe 
    50                  55                  60                  


Pro Trp Lys Leu Ala Lys Asp Pro Gln Met Ser Ile Ala Trp Lys Trp 
65                  70                  75                  80  


Lys Asp Phe His Gly Glu Val Ile Tyr Asn Ser Ser Leu Pro Phe Ile 
                85                  90                  95      


His Glu His Phe Lys Gly Arg Leu Ile Leu Asn Trp Thr Gln Gly Gln 
            100                 105                 110         


Thr Ser Gly Val Leu Arg Ile Leu Asn Leu Lys Glu Ser Asp Gln Ala 
        115                 120                 125             


Gln Tyr Phe Ser Arg Val Asn Leu Gln Ser Thr Glu Gly Met Lys Leu 
    130                 135                 140                 


Trp Gln Ser Ile Pro Gly Thr Gln Leu Asn Val Thr Gln Ala Leu Asn 
145                 150                 155                 160 


Thr Thr Met Arg Ser Pro Phe Ile Val Thr Ser Glu Phe Thr Thr Ala 
                165                 170                 175     


Gly Leu Glu His Thr Ser Asp Gln Arg Asn Pro Ser Leu Met Asn Leu 
            180                 185                 190         


Gly Ala Met Val Thr Met Leu Leu Ala Lys Val Leu Val Ile Val Leu 
        195                 200                 205             


Val Tyr Gly Trp Met Ile Phe Leu Arg Trp Lys Gln Arg Pro Ala His 
    210                 215                 220                 


<210> 34
<211> 196
<212> PRT
<213> Mus sp.

<400> 34
Gly Asn Ser Glu Arg Tyr Asn Arg Lys Asn Gly Phe Gly Val Asn Gln 
1               5                   10                  15      


Pro Glu Arg Cys Ser Gly Val Gln Gly Gly Ser Ile Asp Ile Pro Phe 
            20                  25                  30          


Ser Phe Tyr Phe Pro Trp Lys Leu Ala Lys Asp Pro Gln Met Ser Ile 
        35                  40                  45              


Ala Trp Lys Trp Lys Asp Phe His Gly Glu Val Ile Tyr Asn Ser Ser 
    50                  55                  60                  


Leu Pro Phe Ile His Glu His Phe Lys Gly Arg Leu Ile Leu Asn Trp 
65                  70                  75                  80  


Thr Gln Gly Gln Thr Ser Gly Val Leu Arg Ile Leu Asn Leu Lys Glu 
                85                  90                  95      


Ser Asp Gln Ala Gln Tyr Phe Ser Arg Val Asn Leu Gln Ser Thr Glu 
            100                 105                 110         


Gly Met Lys Leu Trp Gln Ser Ile Pro Gly Thr Gln Leu Asn Val Thr 
        115                 120                 125             


Gln Ala Leu Asn Thr Thr Met Arg Ser Pro Phe Ile Val Thr Ser Glu 
    130                 135                 140                 


Phe Thr Thr Ala Gly Leu Glu His Thr Ser Asp Gln Arg Asn Pro Ser 
145                 150                 155                 160 


Leu Met Asn Leu Gly Ala Met Val Thr Met Leu Leu Ala Lys Val Leu 
                165                 170                 175     


Val Ile Val Leu Val Tyr Gly Trp Met Ile Phe Leu Arg Trp Lys Gln 
            180                 185                 190         


Arg Pro Ala His 
        195     


<210> 35
<211> 227
<212> PRT
<213> Homo sapiens

<400> 35
Met Gly Arg Pro Leu Leu Leu Pro Leu Leu Leu Leu Leu Gln Pro Pro 
1               5                   10                  15      


Ala Phe Leu Gln Pro Gly Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu 
            20                  25                  30          


Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser 
        35                  40                  45              


Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Ile Val 
    50                  55                  60                  


Pro Asn Val Arg Ile Ser Trp Arg Arg Gly His Phe His Gly Gln Ser 
65                  70                  75                  80  


Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg 
                85                  90                  95      


Leu Phe Leu Asn Trp Thr Glu Gly Gln Glu Ser Gly Phe Leu Arg Ile 
            100                 105                 110         


Ser Asn Leu Arg Lys Glu Asp Gln Ser Val Tyr Phe Cys Arg Val Glu 
        115                 120                 125             


Leu Asp Thr Arg Arg Ser Gly Arg Gln Gln Leu Gln Ser Ile Lys Gly 
    130                 135                 140                 


Thr Lys Leu Thr Ile Thr Gln Ala Val Thr Thr Thr Thr Thr Trp Arg 
145                 150                 155                 160 


Pro Ser Ser Thr Thr Thr Ile Ala Gly Leu Arg Val Thr Glu Ser Lys 
                165                 170                 175     


Gly His Ser Glu Ser Trp His Leu Ser Leu Asp Thr Ala Ile Arg Val 
            180                 185                 190         


Ala Leu Ala Val Ala Val Leu Lys Thr Val Ile Leu Gly Leu Leu Cys 
        195                 200                 205             


Leu Leu Leu Leu Trp Trp Arg Arg Arg Lys Gly Ser Arg Ala Pro Ser 
    210                 215                 220                 


Ser Asp Phe 
225         


<210> 36
<211> 208
<212> PRT
<213> Homo sapiens

<400> 36
Gln Pro Gly Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu Tyr Gly Val 
1               5                   10                  15      


Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser Val Glu Ile 
            20                  25                  30          


Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Ile Val Pro Asn Val 
        35                  40                  45              


Arg Ile Ser Trp Arg Arg Gly His Phe His Gly Gln Ser Phe Tyr Ser 
    50                  55                  60                  


Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg Leu Phe Leu 
65                  70                  75                  80  


Asn Trp Thr Glu Gly Gln Glu Ser Gly Phe Leu Arg Ile Ser Asn Leu 
                85                  90                  95      


Arg Lys Glu Asp Gln Ser Val Tyr Phe Cys Arg Val Glu Leu Asp Thr 
            100                 105                 110         


Arg Arg Ser Gly Arg Gln Gln Leu Gln Ser Ile Lys Gly Thr Lys Leu 
        115                 120                 125             


Thr Ile Thr Gln Ala Val Thr Thr Thr Thr Thr Trp Arg Pro Ser Ser 
    130                 135                 140                 


Thr Thr Thr Ile Ala Gly Leu Arg Val Thr Glu Ser Lys Gly His Ser 
145                 150                 155                 160 


Glu Ser Trp His Leu Ser Leu Asp Thr Ala Ile Arg Val Ala Leu Ala 
                165                 170                 175     


Val Ala Val Leu Lys Thr Val Ile Leu Gly Leu Leu Cys Leu Leu Leu 
            180                 185                 190         


Leu Trp Trp Arg Arg Arg Lys Gly Ser Arg Ala Pro Ser Ser Asp Phe 
        195                 200                 205             


<210> 37
<211> 5
<212> PRT
<213> Mus sp.

<400> 37
Pro Lys Ala Pro Thr 
1               5   


<210> 38
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      8xHis tag"

<400> 38
His His His His His His His His 
1               5               


<210> 39
<211> 15
<212> PRT
<213> Mus sp.

<400> 39
Asn Met Lys Pro Thr Pro Lys Ala Pro Thr Pro Lys Lys Pro Ser 
1               5                   10                  15  


<210> 40
<211> 26
<212> PRT
<213> Homo sapiens

<400> 40
Ala Pro Asp Gly Gly Phe Leu Asp Leu Ser Asp Ala Leu Pro Asp Asn 
1               5                   10                  15      


Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys 
            20                  25      


<210> 41
<211> 11
<212> PRT
<213> Homo sapiens

<400> 41
Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys 
1               5                   10      


<210> 42
<211> 9
<212> PRT
<213> Herpes simplex virus 

<400> 42
Pro Pro Asn Pro Thr Pro Pro Pro Pro 
1               5                   


<210> 43
<211> 9
<212> PRT
<213> Herpes simplex virus

<400> 43
Gly Gly Pro Ala Thr Pro Ala Pro Pro 
1               5                   


<210> 44
<211> 9
<212> PRT
<213> Mus sp.

<400> 44
Asn Met Lys Pro Thr Pro Lys Ala Pro 
1               5                   


<210> 45
<211> 9
<212> PRT
<213> Mus sp.

<400> 45
Pro Lys Ala Pro Thr Pro Lys Lys Pro 
1               5                   


<210> 46
<211> 6
<212> PRT
<213> Homo sapiens

<400> 46
Ala Ile Pro Lys Lys Pro 
1               5       


<210> 47
<211> 9
<212> PRT
<213> Homo sapiens

<400> 47
Pro Lys Ala Pro Thr Pro Lys Lys Pro 
1               5                   


<210> 48
<211> 14
<212> PRT
<213> Mus sp.

<400> 48
Asn Met Lys Pro Thr Pro Lys Ala Pro Thr Pro Lys Lys Pro 
1               5                   10                  


<210> 49
<211> 14
<212> PRT
<213> Homo sapiens

<400> 49
Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser Ala Gly 
1               5                   10                  


<210> 50
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 50
Asn Lys Lys Pro Thr Pro Lys Ala Pro Thr Ala Ile Pro Lys Lys Pro 
1               5                   10                  15      


Ser Ala Gly 
            


<210> 51
<211> 120
<212> PRT
<213> Homo sapiens

<400> 51
Tyr Leu Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly 
1               5                   10                  15      


Gly Ser Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala 
            20                  25                  30          


Thr Ala Pro Asp Val Arg Ile Ser Trp Arg Arg Gly His Phe His Arg 
        35                  40                  45              


Gln Ser Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val 
    50                  55                  60                  


Asn Arg Leu Phe Leu Asn Trp Thr Glu Gly Gln Lys Ser Gly Phe Leu 
65                  70                  75                  80  


Arg Ile Ser Asn Leu Gln Lys Gln Asp Gln Ser Val Tyr Phe Cys Arg 
                85                  90                  95      


Val Glu Leu Asp Thr Arg Ser Ser Gly Arg Gln Gln Trp Gln Ser Ile 
            100                 105                 110         


Glu Gly Thr Lys Leu Ser Ile Thr 
        115                 120 


<210> 52
<211> 120
<212> PRT
<213> Pan sp.

<400> 52
Tyr Pro Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly 
1               5                   10                  15      


Gly Ser Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala 
            20                  25                  30          


Thr Ala Pro Asp Val Arg Ile Ser Trp Arg Arg Gly His Phe His Gly 
        35                  40                  45              


Gln Ser Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val 
    50                  55                  60                  


Asn Arg Leu Phe Leu Asn Trp Thr Glu Gly Gln Lys Ser Gly Phe Leu 
65                  70                  75                  80  


Arg Ile Ser Asn Leu Arg Lys Gln Asp Gln Ser Val Tyr Phe Cys Arg 
                85                  90                  95      


Val Glu Leu Asp Thr Arg Ser Ser Gly Arg Gln Gln Trp Gln Ser Ile 
            100                 105                 110         


Glu Gly Thr Lys Leu Ser Ile Thr 
        115                 120 


<210> 53
<211> 120
<212> PRT
<213> Bos sp.

<400> 53
Gln His Tyr Glu Met Lys Gln Pro Arg Asp Leu Ser Ala Pro Glu Gly 
1               5                   10                  15      


Gly Ser Ile Leu Ile Pro Phe Ser Phe Ser His Pro Gly Glu Leu Ala 
            20                  25                  30          


Lys Val Pro Asn Met Arg Ile Phe Trp Arg Trp Lys His Phe His Gly 
        35                  40                  45              


Glu Phe Ile Tyr Asn Thr Ser Pro Leu Phe Thr His Lys Asn Phe Lys 
    50                  55                  60                  


Asn Arg Leu Ile Leu Asn Trp Lys Glu Pro Glu Lys Asn Gly Ser Leu 
65                  70                  75                  80  


Gln Ile Ser Asn Leu Arg Arg Glu Asp Gln Ser Met Tyr Phe Cys Arg 
                85                  90                  95      


Val Gln Leu Asp Thr Leu Arg Asp Gly Lys Gln Lys Trp Gln Ser Ile 
            100                 105                 110         


Glu Gly Thr Lys Leu Thr Ile Thr 
        115                 120 


<210> 54
<211> 120
<212> PRT
<213> Canis sp.

<400> 54
Met Asp Phe Arg Met Asp Gln Pro Glu His Leu Ser Ala Pro Lys Gly 
1               5                   10                  15      


Gly Thr Val His Ile Asn Phe Thr Phe Tyr Tyr Cys Gly Ala Leu Ala 
            20                  25                  30          


Lys Asp Pro Arg Val Ser Ile Ala Leu Lys Arg Thr His Phe His Gly 
        35                  40                  45              


Glu Val Ile Tyr Asn Ser Thr Arg His Phe Val His Glu Asp Tyr Lys 
    50                  55                  60                  


Asp Arg Ile Ile Leu Asn Leu Pro Glu Gly Gln Lys Ser Gly Phe Leu 
65                  70                  75                  80  


Gln Ile Leu Asn Leu Arg Glu Glu Asp Glu Asn Met Tyr Phe Cys Arg 
                85                  90                  95      


Val Gln Leu Lys Thr Gln Arg Phe Gly Leu Gln Val Trp Gln Ser Ile 
            100                 105                 110         


Leu Gly Thr Lys Leu Thr Ile Asn 
        115                 120 


<210> 55
<211> 119
<212> PRT
<213> Rattus sp.

<400> 55
Tyr Asp Tyr Gly Val Asp Gln Pro Ala Val Leu Ser Gly Val Gln Gly 
1               5                   10                  15      


Ser Ser Ile Glu Ile Pro Phe Ser Phe Tyr Phe Pro Trp Asn Leu Thr 
            20                  25                  30          


Lys Asp Pro Gln Met Ser Ile Ala Trp Arg Trp Lys Asn Phe His Gly 
        35                  40                  45              


Glu Phe Ile Tyr Asn Ser Thr Gln Pro Phe Ile His Glu His Phe Lys 
    50                  55                  60                  


Asp Arg Leu Ile Met Asn Trp Thr Gln Gly Gln Thr Ser Gly Val Leu 
65                  70                  75                  80  


Arg Ile Leu Asn Phe Lys Lys Asn Asp Gln Ala Thr Tyr Phe Gly Arg 
                85                  90                  95      


Val Leu Leu Gln Thr Thr Glu Gly Met Lys Val Trp Gln Ser Ile Pro 
            100                 105                 110         


Gly Thr Asn Leu Thr Val Thr 
        115                 


<210> 56
<211> 119
<212> PRT
<213> Mus sp.

<400> 56
Asn Gly Phe Gly Val Asn Gln Pro Glu Ser Cys Ser Gly Val Gln Gly 
1               5                   10                  15      


Gly Ser Ile Asp Ile Pro Phe Ser Phe Tyr Phe Pro Trp Lys Leu Ala 
            20                  25                  30          


Lys Asp Pro Gln Met Ser Ile Ala Trp Arg Trp Lys Asp Phe His Gly 
        35                  40                  45              


Glu Phe Ile Tyr Asn Ser Ser Leu Pro Phe Ile His Glu His Phe Lys 
    50                  55                  60                  


Gly Arg Leu Ile Leu Asn Trp Thr Gln Gly Gln Thr Ser Gly Val Leu 
65                  70                  75                  80  


Arg Ile Leu Asn Leu Lys Glu Ser Asp Gln Thr Arg Tyr Phe Gly Arg 
                85                  90                  95      


Val Phe Leu Gln Thr Thr Glu Gly Ile Gln Phe Trp Gln Ser Ile Pro 
            100                 105                 110         


Gly Thr Gln Leu Asn Val Thr 
        115                 


<210> 57
<211> 120
<212> PRT
<213> Homo sapiens

<400> 57
Tyr Leu Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly 
1               5                   10                  15      


Gly Ser Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala 
            20                  25                  30          


Ile Val Pro Asn Val Arg Ile Ser Trp Arg Arg Gly His Phe His Gly 
        35                  40                  45              


Gln Ser Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val 
    50                  55                  60                  


Asn Arg Leu Phe Leu Asn Trp Thr Glu Gly Gln Glu Ser Gly Phe Leu 
65                  70                  75                  80  


Arg Ile Ser Asn Leu Arg Lys Glu Asp Gln Ser Val Tyr Phe Cys Arg 
                85                  90                  95      


Val Glu Leu Asp Thr Arg Arg Ser Gly Arg Gln Gln Leu Gln Ser Ile 
            100                 105                 110         


Lys Gly Thr Lys Leu Thr Ile Thr 
        115                 120 


<210> 58
<211> 119
<212> PRT
<213> Mus sp.

<400> 58
Asn Gly Phe Gly Val Asn Gln Pro Glu Arg Cys Ser Gly Val Gln Gly 
1               5                   10                  15      


Gly Ser Ile Asp Ile Pro Phe Ser Phe Tyr Phe Pro Trp Lys Leu Ala 
            20                  25                  30          


Lys Asp Pro Gln Met Ser Ile Ala Trp Lys Trp Lys Asp Phe His Gly 
        35                  40                  45              


Glu Val Ile Tyr Asn Ser Ser Leu Pro Phe Ile His Glu His Phe Lys 
    50                  55                  60                  


Gly Arg Leu Ile Leu Asn Trp Thr Gln Gly Gln Thr Ser Gly Val Leu 
65                  70                  75                  80  


Arg Ile Leu Asn Leu Lys Glu Ser Asp Gln Ala Gln Tyr Phe Ser Arg 
                85                  90                  95      


Val Asn Leu Gln Ser Thr Glu Gly Met Lys Leu Trp Gln Ser Ile Pro 
            100                 105                 110         


Gly Thr Gln Leu Asn Val Thr 
        115                 


<210> 59
<211> 118
<212> PRT
<213> Homo sapiens

<400> 59
Ala Ser Trp Gly Val Ser Ser Pro Gln Asp Val Gln Gly Val Lys Gly 
1               5                   10                  15      


Ser Cys Leu Leu Ile Pro Cys Ile Phe Ser Phe Pro Ala Asp Val Glu 
            20                  25                  30          


Val Pro Asp Gly Ile Thr Ala Ile Trp Tyr Tyr Asp Tyr Ser Gly Gln 
        35                  40                  45              


Arg Gln Val Val Ser His Ser Ala Asp Pro Lys Leu Val Glu Ala Arg 
    50                  55                  60                  


Phe Arg Gly Arg Thr Glu Phe Met Gly Asn Pro Glu His Arg Val Cys 
65                  70                  75                  80  


Asn Leu Leu Leu Lys Asp Leu Gln Pro Glu Asp Ser Gly Ser Tyr Asn 
                85                  90                  95      


Phe Arg Phe Glu Ile Ser Glu Val Asn Arg Trp Ser Asp Val Lys Gly 
            100                 105                 110         


Thr Leu Val Thr Val Thr 
        115             


<210> 60
<211> 118
<212> PRT
<213> Mus sp.

<400> 60
Thr Thr Trp Gly Val Ser Ser Pro Lys Asn Val Gln Gly Leu Ser Gly 
1               5                   10                  15      


Ser Cys Leu Leu Ile Pro Cys Ile Phe Ser Tyr Pro Ala Asp Val Pro 
            20                  25                  30          


Val Ser Asn Gly Ile Thr Ala Ile Trp Tyr Tyr Asp Tyr Ser Gly Lys 
        35                  40                  45              


Arg Gln Val Val Ile His Ser Gly Asp Pro Lys Leu Val Asp Lys Arg 
    50                  55                  60                  


Phe Arg Gly Arg Ala Glu Leu Met Gly Asn Met Asp His Lys Val Cys 
65                  70                  75                  80  


Asn Leu Leu Leu Lys Asp Leu Lys Pro Glu Asp Ser Gly Thr Tyr Asn 
                85                  90                  95      


Phe Arg Phe Glu Ile Ser Asp Ser Asn Arg Trp Leu Asp Val Lys Gly 
            100                 105                 110         


Thr Thr Val Thr Val Thr 
        115             


<210> 61
<211> 230
<212> PRT
<213> Homo sapiens

<400> 61
Met Gly Arg Pro Leu Leu Leu Pro Leu Leu Pro Leu Leu Leu Pro Pro 
1               5                   10                  15      


Ala Phe Leu Gln Pro Ser Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu 
            20                  25                  30          


Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser 
        35                  40                  45              


Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Thr Ala 
    50                  55                  60                  


Pro Asp Val Arg Ile Ser Trp Arg Arg Gly His Phe His Arg Gln Ser 
65                  70                  75                  80  


Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg 
                85                  90                  95      


Leu Phe Leu Asn Trp Thr Glu Gly Gln Lys Ser Gly Phe Leu Arg Ile 
            100                 105                 110         


Ser Asn Leu Gln Lys Gln Asp Gln Ser Val Tyr Phe Cys Arg Val Glu 
        115                 120                 125             


Leu Asp Thr Arg Ser Ser Gly Arg Gln Gln Trp Gln Ser Ile Glu Gly 
    130                 135                 140                 


Thr Lys Leu Ser Ile Thr Gln Gly Gln Gln Arg Thr Lys Ala Thr Thr 
145                 150                 155                 160 


Pro Ala Arg Glu Pro Phe Gln Asn Thr Glu Glu Pro Tyr Glu Asn Ile 
                165                 170                 175     


Arg Asn Glu Gly Gln Asn Thr Asp Pro Lys Leu Asn Pro Lys Asp Asp 
            180                 185                 190         


Gly Ile Val Tyr Ala Ser Leu Ala Leu Ser Ser Ser Thr Ser Pro Arg 
        195                 200                 205             


Ala Pro Pro Ser His Arg Pro Leu Lys Ser Pro Gln Asn Glu Thr Leu 
    210                 215                 220                 


Tyr Ser Val Leu Lys Ala 
225                 230 


<210> 62
<211> 226
<212> PRT
<213> Homo sapiens

<400> 62
Met Gly Arg Pro Leu Leu Leu Pro Leu Leu Pro Leu Leu Leu Pro Pro 
1               5                   10                  15      


Ala Phe Leu Gln Pro Ser Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu 
            20                  25                  30          


Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser 
        35                  40                  45              


Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Thr Ala 
    50                  55                  60                  


Pro Asp Val Arg Ile Ser Trp Arg Arg Gly His Phe His Gly Gln Ser 
65                  70                  75                  80  


Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg 
                85                  90                  95      


Leu Phe Leu Asn Trp Thr Glu Gly Gln Lys Ser Gly Phe Leu Arg Ile 
            100                 105                 110         


Ser Asn Leu Gln Lys Gln Asp Gln Ser Val Tyr Phe Cys Arg Val Glu 
        115                 120                 125             


Leu Asp Thr Arg Ser Ser Gly Arg Gln Gln Trp Gln Ser Ile Glu Gly 
    130                 135                 140                 


Thr Lys Leu Ser Ile Thr Gln Gly Gln Gln Arg Thr Lys Ala Thr Thr 
145                 150                 155                 160 


Pro Ala Arg Glu Pro Phe Gln Asn Thr Glu Glu Pro Tyr Glu Asn Ile 
                165                 170                 175     


Arg Asn Glu Gly Gln Asn Thr Asp Pro Lys Leu Asn Pro Lys Leu His 
            180                 185                 190         


Leu Thr Gln Ser Thr Ser Gln Pro Pro Ser Pro Gln Glu Pro Pro Glu 
        195                 200                 205             


Arg Asp Pro Val Leu Cys Leu Lys Gly Leu Thr Asn Gly Gln Pro Ser 
    210                 215                 220                 


Gln Asp 
225     


<210> 63
<211> 175
<212> PRT
<213> Homo sapiens

<400> 63
Met Gly Arg Pro Leu Leu Leu Pro Leu Leu Pro Leu Leu Leu Pro Pro 
1               5                   10                  15      


Ala Phe Leu Gln Pro Ser Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu 
            20                  25                  30          


Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser 
        35                  40                  45              


Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Thr Ala 
    50                  55                  60                  


Pro Asp Val Arg Ile Ser Trp Arg Arg Gly His Phe His Arg Gln Ser 
65                  70                  75                  80  


Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg 
                85                  90                  95      


Leu Phe Leu Asn Trp Thr Glu Gly Gln Lys Ser Gly Phe Leu Arg Ile 
            100                 105                 110         


Ser Asn Leu Gln Lys Gln Asp Gln Ser Val Tyr Phe Cys Arg Val Glu 
        115                 120                 125             


Leu Asp Thr Arg Ser Ser Gly Arg Gln Gln Trp Gln Ser Ile Glu Gly 
    130                 135                 140                 


Thr Lys Leu Ser Ile Thr Gln Gly Asn Pro Ser Lys Thr Gln Arg Ser 
145                 150                 155                 160 


His Met Arg Ile Ser Gly Met Lys Asp Lys Ile Gln Ile Pro Ser 
                165                 170                 175 


