                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
       BEDOUELLE, Hugues
       MIRANDA, Frdric
       PECORARI, Frdric
       ZIDANE, Nora
 
<120>  Reagentless fluorescent biosensors from Nanofitins, rational 
       design methods to create reagentless fluorescent biosensors and 
       methods of their use

<130>  F226PCT182

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  66
<212>  PRT
<213>  Sulfolobus acidocaldarius

<400>  1

Met Val Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Val Ser Phe 
            20                  25                  30          


Thr Tyr Asp Asp Asn Gly Lys Thr Gly Arg Gly Ala Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  2
<211>  65
<212>  PRT
<213>  Sulfolobus acidocaldarius

<400>  2

Met Ala Lys Val Arg Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Val Ser Phe 
            20                  25                  30          


Thr Tyr Asp Asp Asn Gly Lys Thr Gly Arg Gly Ala Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Met Asp Met Leu Ala Arg Ala Glu Lys Lys 
    50                  55                  60                  


Lys 
65  


<210>  3
<211>  64
<212>  PRT
<213>  Sulfolobus solfataricus

<400>  3

Met Ala Thr Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Ile Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Ile Ser Phe 
            20                  25                  30          


Thr Tyr Asp Glu Gly Gly Gly Lys Thr Gly Arg Gly Ala Val Ser Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Lys Lys 
    50                  55                  60                  


<210>  4
<211>  64
<212>  PRT
<213>  Sulfolobus tokodaii

<400>  4

Met Val Thr Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Ile Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Ile Ser Phe 
            20                  25                  30          


Thr Tyr Asp Asp Asn Gly Lys Thr Gly Arg Gly Ala Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Ser Gly Lys Lys 
    50                  55                  60                  


<210>  5
<211>  64
<212>  PRT
<213>  Sulfolobus shibatae

<400>  5

Met Val Thr Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Ile Ser Phe 
            20                  25                  30          


Thr Tyr Asp Glu Gly Gly Gly Lys Thr Gly Arg Gly Ala Val Ser Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Lys Lys 
    50                  55                  60                  


<210>  6
<211>  64
<212>  PRT
<213>  Sulfolobus shibatae

<400>  6

Met Ala Thr Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Gln Val Asp 
1               5                   10                  15      


Ile Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Ile Ser Phe 
            20                  25                  30          


Thr Tyr Asp Glu Gly Gly Gly Lys Thr Gly Arg Gly Ala Val Ser Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Lys Lys 
    50                  55                  60                  


<210>  7
<211>  64
<212>  PRT
<213>  Sulfolobus solfataricus

<400>  7

Met Ala Thr Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Gln Val Asp 
1               5                   10                  15      


Ile Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Ile Ser Phe 
            20                  25                  30          


Thr Tyr Asp Glu Gly Gly Gly Lys Thr Gly Arg Gly Ala Val Ser Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Lys Lys 
    50                  55                  60                  


<210>  8
<211>  87
<212>  PRT
<213>  Escherichia coli


<220>
<221>  mat_peptide
<222>  (20)..(87)

<400>  8

Met Lys Lys Met Phe Met Ala Val Leu Phe Ala Leu Val Ser Val Asn 
                -15                 -10                 -5      


Ala Met Ala Ala Asp Cys Ala Lys Gly Lys Ile Glu Phe Ser Lys Tyr 
        -1  1               5                   10              


Asn Glu Asp Asp Thr Phe Thr Val Lys Val Ser Gly Arg Glu Tyr Trp 
    15                  20                  25                  


Thr Asn Arg Trp Asn Leu Gln Pro Leu Leu Gln Ser Ala Gln Leu Thr 
30                  35                  40                  45  


Gly Met Thr Val Thr Ile Ile Ser Asn Thr Cys Ser Ser Gly Ser Gly 
                50                  55                  60      


Phe Ala Glu Val Gln Phe Asn 
            65              


<210>  9
<211>  89
<212>  PRT
<213>  Escherichia coli


<220>
<221>  mat_peptide
<222>  (20)..(89)

<400>  9

Met Lys Lys Met Phe Met Ala Val Leu Phe Ala Leu Val Ser Val Asn 
                -15                 -10                 -5      


Ala Met Ala Ala Asp Cys Ala Lys Gly Lys Ile Glu Phe Ser Lys Tyr 
        -1  1               5                   10              


Asn Glu Asp Asp Thr Phe Thr Val Lys Val Asp Gly Lys Glu Tyr Trp 
    15                  20                  25                  


Thr Ser Arg Trp Asn Leu Gln Pro Leu Leu Gln Ser Ala Gln Leu Thr 
30                  35                  40                  45  


Gly Met Thr Val Thr Ile Lys Ser Ser Thr Cys Glu Ser Gly Ser Gly 
                50                  55                  60      


Phe Ala Glu Val Gln Phe Asn Asn Asp 
            65                  70  


<210>  10
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Leu Arg Leu Asp Thr Thr Pro Ser Cys Asn Ser Ala Arg Pro 
1               5                   10                  15      


Leu His Ala Leu Gln Val Leu Leu Leu Leu Ser Leu Leu Leu Thr Ala 
            20                  25                  30          


Leu Ala Ser Ser Thr Lys Gly Gln Thr Lys Arg Asn Leu Ala Lys Gly 
        35                  40                  45              


Lys Glu Glu Ser Leu Asp Ser Asp Leu Tyr Ala Glu Leu Arg Cys Met 
    50                  55                  60                  


Cys Ile Lys Thr Thr Ser Gly Ile His Pro Lys Asn Ile Gln Ser Leu 
65                  70                  75                  80  


Glu Val Ile Gly Lys Gly Thr His Cys Asn Gln Val Glu Val Ile Ala 
                85                  90                  95      


Thr Leu Lys Asp Gly Arg Lys Ile Cys Leu Asp Pro Asp Ala Pro Arg 
            100                 105                 110         


Ile Lys Lys Ile Val Gln Lys Lys Leu Ala Gly Asp Glu Ser Ala Asp 
        115                 120                 125             


<210>  11
<211>  142
<212>  PRT
<213>  Azotobacter vinelandii

<400>  11

Met Lys Ile Ser Ala Arg Asn Val Phe Lys Gly Thr Val Ser Ala Leu 
1               5                   10                  15      


Lys Glu Gly Ala Val Asn Ala Glu Val Asp Ile Leu Leu Gly Gly Gly 
            20                  25                  30          


Asp Lys Leu Ala Ala Val Val Thr Leu Glu Ser Ala Arg Ser Leu Gln 
        35                  40                  45              


Leu Ala Ala Gly Lys Glu Val Val Ala Val Val Lys Ala Pro Trp Val 
    50                  55                  60                  


Leu Leu Met Thr Asp Ser Ser Gly Tyr Arg Leu Ser Ala Arg Asn Ile 
65                  70                  75                  80  


Leu Thr Gly Thr Val Lys Thr Ile Glu Thr Gly Ala Val Asn Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Leu Gln Gly Gly Thr Glu Ile Thr Ser Met Val Thr 
            100                 105                 110         


Lys Glu Ala Val Ala Glu Leu Gly Leu Lys Pro Gly Ala Ser Ala Ser 
        115                 120                 125             


Ala Val Ile Lys Ala Ser Asn Val Ile Leu Gly Val Pro Ala 
    130                 135                 140         


<210>  12
<211>  505
<212>  PRT
<213>  Escherichia coli


<220>
<221>  CONFLICT
<222>  (30)..(30)

<220>
<221>  domain OB-fold
<222>  (31)..(149)

<400>  12

Met Ser Glu Gln His Ala Gln Gly Ala Asp Ala Val Val Asp Leu Asn 
1               5                   10                  15      


Asn Glu Leu Lys Thr Arg Arg Glu Lys Leu Ala Asn Leu Arg Glu Gln 
            20                  25                  30          


Gly Ile Ala Phe Pro Asn Asp Phe Arg Arg Asp His Thr Ser Asp Gln 
        35                  40                  45              


Leu His Ala Glu Phe Asp Gly Lys Glu Asn Glu Glu Leu Glu Ala Leu 
    50                  55                  60                  


Asn Ile Glu Val Ala Val Ala Gly Arg Met Met Thr Arg Arg Ile Met 
65                  70                  75                  80  


Gly Lys Ala Ser Phe Val Thr Leu Gln Asp Val Gly Gly Arg Ile Gln 
                85                  90                  95      


Leu Tyr Val Ala Arg Asp Asp Leu Pro Glu Gly Val Tyr Asn Glu Gln 
            100                 105                 110         


Phe Lys Lys Trp Asp Leu Gly Asp Ile Leu Gly Ala Lys Gly Lys Leu 
        115                 120                 125             


Phe Lys Thr Lys Thr Gly Glu Leu Ser Ile His Cys Thr Glu Leu Arg 
    130                 135                 140                 


Leu Leu Thr Lys Ala Leu Arg Pro Leu Pro Asp Lys Phe His Gly Leu 
145                 150                 155                 160 


Gln Asp Gln Glu Ala Arg Tyr Arg Gln Arg Tyr Leu Asp Leu Ile Ser 
                165                 170                 175     


Asn Asp Glu Ser Arg Asn Thr Phe Lys Val Arg Ser Gln Ile Leu Ser 
            180                 185                 190         


Gly Ile Arg Gln Phe Met Val Asn Arg Gly Phe Met Glu Val Glu Thr 
        195                 200                 205             


Pro Met Met Gln Val Ile Pro Gly Gly Ala Ala Ala Arg Pro Phe Ile 
    210                 215                 220                 


Thr His His Asn Ala Leu Asp Leu Asp Met Tyr Leu Arg Ile Ala Pro 
225                 230                 235                 240 


Glu Leu Tyr Leu Lys Arg Leu Val Val Gly Gly Phe Glu Arg Val Phe 
                245                 250                 255     


Glu Ile Asn Arg Asn Phe Arg Asn Glu Gly Ile Ser Val Arg His Asn 
            260                 265                 270         


Pro Glu Phe Thr Met Met Glu Leu Tyr Met Ala Tyr Ala Asp Tyr Lys 
        275                 280                 285             


Asp Leu Ile Glu Leu Thr Glu Ser Leu Phe Arg Thr Leu Ala Gln Asp 
    290                 295                 300                 


Ile Leu Gly Lys Thr Glu Val Thr Tyr Gly Asp Val Thr Leu Asp Phe 
305                 310                 315                 320 


Gly Lys Pro Phe Glu Lys Leu Thr Met Arg Glu Ala Ile Lys Lys Tyr 
                325                 330                 335     


Arg Ser Glu Thr Asp Met Ala Asp Leu Asp Asn Phe Asp Ser Ala Lys 
            340                 345                 350         


Ala Ile Ala Glu Ser Ile Gly Ile His Val Glu Lys Ser Trp Gly Leu 
        355                 360                 365             


Gly Arg Ile Val Thr Glu Ile Phe Glu Glu Val Ala Glu Ala His Leu 
    370                 375                 380                 


Ile Gln Pro Thr Phe Ile Thr Glu Tyr Pro Ala Glu Val Ser Pro Leu 
385                 390                 395                 400 


Ala Arg Arg Asn Asp Val Asn Pro Glu Ile Thr Asp Arg Phe Glu Phe 
                405                 410                 415     


Phe Ile Gly Gly Arg Glu Ile Gly Asn Gly Phe Ser Glu Leu Asn Asp 
            420                 425                 430         


Ala Glu Asp Gln Ala Gln Arg Phe Leu Asp Gln Val Ala Ala Lys Asp 
        435                 440                 445             


Ala Gly Asp Asp Glu Ala Met Phe Tyr Asp Glu Asp Tyr Val Thr Ala 
    450                 455                 460                 


Leu Glu His Gly Leu Pro Pro Thr Ala Gly Leu Gly Ile Gly Ile Asp 
465                 470                 475                 480 


Arg Met Val Met Leu Phe Thr Asn Ser His Thr Ile Arg Asp Val Ile 
                485                 490                 495     


Leu Phe Pro Ala Met Arg Pro Val Lys 
            500                 505 


<210>  13
<211>  585
<212>  PRT
<213>  Escherichia coli


<220>
<221>  OB-fold domain
<222>  (14)..(106)

<400>  13

Met Arg Thr Glu Tyr Cys Gly Gln Leu Arg Leu Ser His Val Gly Gln 
1               5                   10                  15      


Gln Val Thr Leu Cys Gly Trp Val Asn Arg Arg Arg Asp Leu Gly Ser 
            20                  25                  30          


Leu Ile Phe Ile Asp Met Arg Asp Arg Glu Gly Ile Val Gln Val Phe 
        35                  40                  45              


Phe Asp Pro Asp Arg Ala Asp Ala Leu Lys Leu Ala Ser Glu Leu Arg 
    50                  55                  60                  


Asn Glu Phe Cys Ile Gln Val Thr Gly Thr Val Arg Ala Arg Asp Glu 
65                  70                  75                  80  


Lys Asn Ile Asn Arg Asp Met Ala Thr Gly Glu Ile Glu Val Leu Ala 
                85                  90                  95      


Ser Ser Leu Thr Ile Ile Asn Arg Ala Asp Val Leu Pro Leu Asp Ser 
            100                 105                 110         


Asn His Val Asn Thr Glu Glu Ala Arg Leu Lys Tyr Arg Tyr Leu Asp 
        115                 120                 125             


Leu Arg Arg Pro Glu Met Ala Gln Arg Leu Lys Thr Arg Ala Lys Ile 
    130                 135                 140                 


Thr Ser Leu Val Arg Arg Phe Met Asp Asp His Gly Phe Leu Asp Ile 
145                 150                 155                 160 


Glu Thr Pro Met Leu Thr Lys Ala Thr Pro Glu Gly Ala Arg Asp Tyr 
                165                 170                 175     


Leu Val Pro Ser Arg Val His Lys Gly Lys Phe Tyr Ala Leu Pro Gln 
            180                 185                 190         


Ser Pro Gln Leu Phe Lys Gln Leu Leu Met Met Ser Gly Phe Asp Arg 
        195                 200                 205             


Tyr Tyr Gln Ile Val Lys Cys Phe Arg Asp Glu Asp Leu Arg Ala Asp 
    210                 215                 220                 


Arg Gln Pro Glu Phe Thr Gln Ile Asp Val Glu Thr Ser Phe Met Thr 
225                 230                 235                 240 


Ala Pro Gln Val Arg Glu Val Met Glu Ala Leu Val Arg His Leu Trp 
                245                 250                 255     


Leu Glu Val Lys Gly Val Asp Leu Gly Asp Phe Pro Val Met Thr Phe 
            260                 265                 270         


Ala Glu Ala Glu Arg Arg Tyr Gly Ser Asp Lys Pro Asp Leu Arg Asn 
        275                 280                 285             


Pro Met Glu Leu Thr Asp Val Ala Asp Leu Leu Lys Ser Val Glu Phe 
    290                 295                 300                 


Ala Val Phe Ala Gly Pro Ala Asn Asp Pro Lys Gly Arg Val Ala Ala 
305                 310                 315                 320 


Leu Arg Val Pro Gly Gly Ala Ser Leu Thr Arg Lys Gln Ile Asp Glu 
                325                 330                 335     


Tyr Gly Asn Phe Val Lys Ile Tyr Gly Ala Lys Gly Leu Ala Tyr Ile 
            340                 345                 350         


Lys Val Asn Glu Arg Ala Lys Gly Leu Glu Gly Ile Asn Ser Pro Val 
        355                 360                 365             


Ala Lys Phe Leu Asn Ala Glu Ile Ile Glu Asp Ile Leu Asp Arg Thr 
    370                 375                 380                 


Ala Ala Gln Asp Gly Asp Met Ile Phe Phe Gly Ala Asp Asn Lys Lys 
385                 390                 395                 400 


Ile Val Ala Asp Ala Met Gly Ala Leu Arg Leu Lys Val Gly Lys Asp 
                405                 410                 415     


Leu Gly Leu Thr Asp Glu Ser Lys Trp Ala Pro Leu Trp Val Ile Asp 
            420                 425                 430         


Phe Pro Met Phe Glu Asp Asp Gly Glu Gly Gly Leu Thr Ala Met His 
        435                 440                 445             


His Pro Phe Thr Ser Pro Lys Asp Met Thr Ala Ala Glu Leu Lys Ala 
    450                 455                 460                 


Ala Pro Glu Asn Ala Val Ala Asn Ala Tyr Asp Met Val Ile Asn Gly 
465                 470                 475                 480 


Tyr Glu Val Gly Gly Gly Ser Val Arg Ile His Asn Gly Asp Met Gln 
                485                 490                 495     


Gln Thr Val Phe Gly Ile Leu Gly Ile Asn Glu Glu Glu Gln Arg Glu 
            500                 505                 510         


Lys Phe Gly Phe Leu Leu Asp Ala Leu Lys Tyr Gly Thr Pro Pro His 
        515                 520                 525             


Ala Gly Leu Ala Phe Gly Leu Asp Arg Leu Thr Met Leu Leu Thr Gly 
    530                 535                 540                 


Thr Asp Asn Ile Arg Asp Val Ile Ala Phe Pro Lys Thr Thr Ala Ala 
545                 550                 555                 560 


Ala Cys Leu Met Thr Glu Ala Pro Ser Phe Ala Asn Pro Thr Ala Leu 
                565                 570                 575     


Ala Glu Leu Ser Ile Gln Val Val Lys 
            580                 585 


<210>  14
<211>  438
<212>  PRT
<213>  Thermococcus kodakaraensis


<220>
<221>  domain OB-fold
<222>  (15)..(100)

<400>  14

Met Tyr Arg Thr His Tyr Ser Ser Glu Ile Thr Glu Glu Leu Asn Gly 
1               5                   10                  15      


Gln Lys Val Lys Val Ala Gly Trp Val Trp Glu Val Lys Asp Leu Gly 
            20                  25                  30          


Gly Ile Lys Phe Leu Trp Ile Arg Asp Arg Asp Gly Ile Val Gln Ile 
        35                  40                  45              


Thr Ala Pro Lys Lys Lys Val Asp Pro Glu Leu Phe Lys Leu Ile Pro 
    50                  55                  60                  


Lys Leu Arg Ser Glu Asp Val Val Ala Val Glu Gly Val Val Asn Phe 
65                  70                  75                  80  


Thr Pro Lys Ala Lys Leu Gly Phe Glu Ile Leu Pro Glu Lys Ile Val 
                85                  90                  95      


Val Leu Asn Arg Ala Glu Thr Pro Leu Pro Leu Asp Pro Thr Gly Lys 
            100                 105                 110         


Val Lys Ala Glu Leu Asp Thr Arg Leu Asp Asn Arg Phe Met Asp Leu 
        115                 120                 125             


Arg Arg Pro Glu Val Met Ala Ile Phe Lys Ile Arg Ser Ser Val Phe 
    130                 135                 140                 


Lys Ala Val Arg Asp Phe Phe His Glu Asn Gly Phe Ile Glu Ile His 
145                 150                 155                 160 


Thr Pro Lys Ile Ile Ala Thr Ala Thr Glu Gly Gly Thr Glu Leu Phe 
                165                 170                 175     


Pro Met Lys Tyr Phe Glu Glu Asp Ala Phe Leu Ala Gln Ser Pro Gln 
            180                 185                 190         


Leu Tyr Lys Gln Ile Met Met Ala Ser Gly Leu Asp Arg Val Tyr Glu 
        195                 200                 205             


Ile Ala Pro Ile Phe Arg Ala Glu Glu His Asn Thr Thr Arg His Leu 
    210                 215                 220                 


Asn Glu Ala Trp Ser Ile Asp Ser Glu Met Ala Phe Ile Glu Asp Glu 
225                 230                 235                 240 


Glu Glu Val Met Ser Phe Leu Glu Arg Leu Val Ala His Ala Ile Asn 
                245                 250                 255     


Tyr Val Arg Glu His Asn Ala Lys Glu Leu Asp Ile Leu Asn Phe Glu 
            260                 265                 270         


Leu Glu Glu Pro Lys Leu Pro Phe Pro Arg Val Ser Tyr Asp Lys Ala 
        275                 280                 285             


Leu Glu Ile Leu Gly Asp Leu Gly Lys Glu Ile Pro Trp Gly Glu Asp 
    290                 295                 300                 


Ile Asp Thr Glu Gly Glu Arg Leu Leu Gly Lys Tyr Met Met Glu Asn 
305                 310                 315                 320 


Glu Asn Ala Pro Leu Tyr Phe Leu Tyr Gln Tyr Pro Ser Glu Ala Lys 
                325                 330                 335     


Pro Phe Tyr Ile Met Lys Tyr Asp Asn Lys Pro Glu Ile Cys Arg Ala 
            340                 345                 350         


Phe Asp Leu Glu Tyr Arg Gly Val Glu Ile Ser Ser Gly Gly Gln Arg 
        355                 360                 365             


Glu His Arg His Asp Ile Leu Val Glu Gln Ile Lys Glu Lys Gly Leu 
    370                 375                 380                 


Asn Pro Glu Ser Phe Glu Phe Tyr Leu Lys Ala Phe Arg Tyr Gly Met 
385                 390                 395                 400 


Pro Pro His Gly Gly Phe Gly Leu Gly Ala Glu Arg Leu Ile Lys Gln 
                405                 410                 415     


Met Leu Asp Leu Pro Asn Ile Arg Glu Val Ile Leu Phe Pro Arg Asp 
            420                 425                 430         


Arg Arg Arg Leu Thr Pro 
        435             


<210>  15
<211>  504
<212>  PRT
<213>  Escherichia coli


<220>
<221>  domain OB-fold
<222>  (65)..(150)

<400>  15

Ser Glu Gln Glu Thr Arg Gly Ala Asn Glu Ala Ile Asp Phe Asn Asp 
1               5                   10                  15      


Glu Leu Arg Asn Arg Arg Glu Lys Leu Ala Ala Leu Arg Gln Gln Gly 
            20                  25                  30          


Val Ala Phe Pro Asn Asp Phe Arg Arg Asp His Thr Ser Asp Gln Leu 
        35                  40                  45              


His Glu Glu Phe Asp Ala Lys Asp Asn Gln Glu Leu Glu Ser Leu Asn 
    50                  55                  60                  


Ile Glu Val Ser Val Ala Gly Arg Met Met Thr Arg Arg Ile Met Gly 
65                  70                  75                  80  


Lys Ala Ser Phe Val Thr Leu Gln Asp Val Gly Gly Arg Ile Gln Leu 
                85                  90                  95      


Tyr Val Ala Arg Asp Ser Leu Pro Glu Gly Val Tyr Asn Asp Gln Phe 
            100                 105                 110         


Lys Lys Trp Asp Leu Gly Asp Ile Ile Gly Ala Arg Gly Thr Leu Phe 
        115                 120                 125             


Lys Thr Gln Thr Gly Glu Leu Ser Ile His Cys Thr Glu Leu Arg Leu 
    130                 135                 140                 


Leu Thr Lys Ala Leu Arg Pro Leu Pro Asp Lys Phe His Gly Leu Gln 
145                 150                 155                 160 


Asp Gln Glu Val Arg Tyr Arg Gln Arg Tyr Leu Asp Leu Ile Ala Asn 
                165                 170                 175     


Asp Lys Ser Arg Gln Thr Phe Val Val Arg Ser Lys Ile Leu Ala Ala 
            180                 185                 190         


Ile Arg Gln Phe Met Val Ala Arg Gly Phe Met Glu Val Glu Thr Pro 
        195                 200                 205             


Met Met Gln Val Ile Pro Gly Gly Ala Ser Ala Arg Pro Phe Ile Thr 
    210                 215                 220                 


His His Asn Ala Leu Asp Leu Asp Met Tyr Leu Arg Ile Ala Pro Glu 
225                 230                 235                 240 


Leu Tyr Leu Lys Arg Leu Val Val Gly Gly Phe Glu Arg Val Phe Glu 
                245                 250                 255     


Ile Asn Arg Asn Phe Arg Asn Glu Gly Ile Ser Val Arg His Asn Pro 
            260                 265                 270         


Glu Phe Thr Met Met Glu Leu Tyr Met Ala Tyr Ala Asp Tyr His Asp 
        275                 280                 285             


Leu Ile Glu Leu Thr Glu Ser Leu Phe Arg Thr Leu Ala Gln Glu Val 
    290                 295                 300                 


Leu Gly Thr Thr Lys Val Thr Tyr Gly Glu His Val Phe Asp Phe Gly 
305                 310                 315                 320 


Lys Pro Phe Glu Lys Leu Thr Met Arg Glu Ala Ile Lys Lys Tyr Arg 
                325                 330                 335     


Pro Glu Thr Asp Met Ala Asp Leu Asp Asn Phe Asp Ala Ala Lys Ala 
            340                 345                 350         


Leu Ala Glu Ser Ile Gly Ile Thr Val Glu Lys Ser Trp Gly Leu Gly 
        355                 360                 365             


Arg Ile Val Thr Glu Ile Phe Asp Glu Val Ala Glu Ala His Leu Ile 
    370                 375                 380                 


Gln Pro Thr Phe Ile Thr Glu Tyr Pro Ala Glu Val Ser Pro Leu Ala 
385                 390                 395                 400 


Arg Arg Asn Asp Val Asn Pro Glu Ile Thr Asp Arg Phe Glu Phe Phe 
                405                 410                 415     


Ile Gly Gly Arg Glu Ile Gly Asn Gly Phe Ser Glu Leu Asn Asp Ala 
            420                 425                 430         


Glu Asp Gln Ala Glu Arg Phe Gln Glu Gln Val Asn Ala Lys Ala Ala 
        435                 440                 445             


Gly Asp Asp Glu Ala Met Phe Tyr Asp Glu Asp Tyr Val Thr Ala Leu 
    450                 455                 460                 


Glu Tyr Gly Leu Pro Pro Thr Ala Gly Leu Gly Ile Gly Ile Asp Arg 
465                 470                 475                 480 


Met Ile Met Leu Phe Thr Asn Ser His Thr Ile Arg Asp Val Ile Leu 
                485                 490                 495     


Phe Pro Ala Met Arg Pro Gln Lys 
            500                 


<210>  16
<211>  270
<212>  PRT
<213>  Homo sapiens


<220>
<221>  domain OB-fold
<222>  (72)..(149)

<400>  16

Met Trp Asn Ser Gly Phe Glu Ser Tyr Gly Ser Ser Ser Tyr Gly Gly 
1               5                   10                  15      


Ala Gly Gly Tyr Thr Gln Ser Pro Gly Gly Phe Gly Ser Pro Ala Pro 
            20                  25                  30          


Ser Gln Ala Glu Lys Lys Ser Arg Ala Arg Ala Gln His Ile Val Pro 
        35                  40                  45              


Cys Thr Ile Ser Gln Leu Leu Ser Ala Thr Leu Val Asp Glu Val Phe 
    50                  55                  60                  


Arg Ile Gly Asn Val Glu Ile Ser Gln Val Thr Ile Val Gly Ile Ile 
65                  70                  75                  80  


Arg His Ala Glu Lys Ala Pro Thr Asn Ile Val Tyr Lys Ile Asp Asp 
                85                  90                  95      


Met Thr Ala Ala Pro Met Asp Val Arg Gln Trp Val Asp Thr Asp Asp 
            100                 105                 110         


Thr Ser Ser Glu Asn Thr Val Val Pro Pro Glu Thr Tyr Val Lys Val 
        115                 120                 125             


Ala Gly His Leu Arg Ser Phe Gln Asn Lys Lys Ser Leu Val Ala Phe 
    130                 135                 140                 


Lys Ile Met Pro Leu Glu Asp Met Asn Glu Phe Thr Thr His Ile Leu 
145                 150                 155                 160 


Glu Val Ile Asn Ala His Met Val Leu Ser Lys Ala Asn Ser Gln Pro 
                165                 170                 175     


Ser Ala Gly Arg Ala Pro Ile Ser Asn Pro Gly Met Ser Glu Ala Gly 
            180                 185                 190         


Asn Phe Gly Gly Asn Ser Phe Met Pro Ala Asn Gly Leu Thr Val Ala 
        195                 200                 205             


Gln Asn Gln Val Leu Asn Leu Ile Lys Ala Cys Pro Arg Pro Glu Gly 
    210                 215                 220                 


Leu Asn Phe Gln Asp Leu Lys Asn Gln Leu Lys His Met Ser Val Ser 
225                 230                 235                 240 


Ser Ile Lys Gln Ala Val Asp Phe Leu Ser Asn Glu Gly His Ile Tyr 
                245                 250                 255     


Ser Thr Val Asp Asp Asp His Phe Lys Ser Thr Asp Ala Glu 
            260                 265                 270 


<210>  17
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  domain OB-fold
<222>  (21)..(87)

<400>  17

Met Val Asp Met Met Asp Leu Pro Arg Ser Arg Ile Asn Ala Gly Met 
1               5                   10                  15      


Leu Ala Gln Phe Ile Asp Lys Pro Val Cys Phe Val Gly Arg Leu Glu 
            20                  25                  30          


Lys Ile His Pro Thr Gly Lys Met Phe Ile Leu Ser Asp Gly Glu Gly 
        35                  40                  45              


Lys Asn Gly Thr Ile Glu Leu Met Glu Pro Leu Asp Glu Glu Ile Ser 
    50                  55                  60                  


Gly Ile Val Glu Val Val Gly Arg Val Thr Ala Lys Ala Thr Ile Leu 
65                  70                  75                  80  


Cys Thr Ser Tyr Val Gln Phe Lys Glu Asp Ser His Pro Phe Asp Leu 
                85                  90                  95      


Gly Leu Tyr Asn Glu Ala Val Lys Ile Ile His Asp Phe Pro Gln Phe 
            100                 105                 110         


Tyr Pro Leu Gly Ile Val Gln His Asp 
        115                 120     


<210>  18
<211>  616
<212>  PRT
<213>  Homo sapiens


<220>
<221>  CONFLICT
<222>  (177)..(180)

<220>
<221>  domain OB-fold
<222>  (195)..(290)

<400>  18

Met Val Gly Gln Leu Ser Glu Gly Ala Ile Ala Ala Ile Met Gln Lys 
1               5                   10                  15      


Gly Asp Thr Asn Ile Lys Pro Ile Leu Gln Val Ile Asn Ile Arg Pro 
            20                  25                  30          


Ile Thr Thr Gly Asn Ser Pro Pro Arg Tyr Arg Leu Leu Met Ser Asp 
        35                  40                  45              


Gly Leu Asn Thr Leu Ser Ser Phe Met Leu Ala Thr Gln Leu Asn Pro 
    50                  55                  60                  


Leu Val Glu Glu Glu Gln Leu Ser Ser Asn Cys Val Cys Gln Ile His 
65                  70                  75                  80  


Arg Phe Ile Val Asn Thr Leu Lys Asp Gly Arg Arg Val Val Ile Leu 
                85                  90                  95      


Met Glu Leu Glu Val Leu Lys Ser Ala Glu Ala Val Gly Val Lys Ile 
            100                 105                 110         


Gly Asn Pro Val Pro Tyr Asn Glu Gly Leu Gly Gln Pro Gln Val Ala 
        115                 120                 125             


Pro Pro Ala Pro Ala Ala Ser Pro Ala Ala Ser Ser Arg Pro Gln Pro 
    130                 135                 140                 


Gln Asn Gly Ser Ser Gly Met Gly Ser Thr Val Ser Lys Ala Tyr Gly 
145                 150                 155                 160 


Ala Ser Lys Thr Phe Gly Lys Ala Ala Gly Pro Ser Leu Ser His Thr 
                165                 170                 175     


Ser Gly Gly Thr Gln Ser Lys Val Val Pro Ile Ala Ser Leu Thr Pro 
            180                 185                 190         


Tyr Gln Ser Lys Trp Thr Ile Cys Ala Arg Val Thr Asn Lys Ser Gln 
        195                 200                 205             


Ile Arg Thr Trp Ser Asn Ser Arg Gly Glu Gly Lys Leu Phe Ser Leu 
    210                 215                 220                 


Glu Leu Val Asp Glu Ser Gly Glu Ile Arg Ala Thr Ala Phe Asn Glu 
225                 230                 235                 240 


Gln Val Asp Lys Phe Phe Pro Leu Ile Glu Val Asn Lys Val Tyr Tyr 
                245                 250                 255     


Phe Ser Lys Gly Thr Leu Lys Ile Ala Asn Lys Gln Phe Thr Ala Val 
            260                 265                 270         


Lys Asn Asp Tyr Glu Met Thr Phe Asn Asn Glu Thr Ser Val Met Pro 
        275                 280                 285             


Cys Glu Asp Asp His His Leu Pro Thr Val Gln Phe Asp Phe Thr Gly 
    290                 295                 300                 


Ile Asp Asp Leu Glu Asn Lys Ser Lys Asp Ser Leu Val Asp Ile Ile 
305                 310                 315                 320 


Gly Ile Cys Lys Ser Tyr Glu Asp Ala Thr Lys Ile Thr Val Arg Ser 
                325                 330                 335     


Asn Asn Arg Glu Val Ala Lys Arg Asn Ile Tyr Leu Met Asp Thr Ser 
            340                 345                 350         


Gly Lys Val Val Thr Ala Thr Leu Trp Gly Glu Asp Ala Asp Lys Phe 
        355                 360                 365             


Asp Gly Ser Arg Gln Pro Val Leu Ala Ile Lys Gly Ala Arg Val Ser 
    370                 375                 380                 


Asp Phe Gly Gly Arg Ser Leu Ser Val Leu Ser Ser Ser Thr Ile Ile 
385                 390                 395                 400 


Ala Asn Pro Asp Ile Pro Glu Ala Tyr Lys Leu Arg Gly Trp Phe Asp 
                405                 410                 415     


Ala Glu Gly Gln Ala Leu Asp Gly Val Ser Ile Ser Asp Leu Lys Ser 
            420                 425                 430         


Gly Gly Val Gly Gly Ser Asn Thr Asn Trp Lys Thr Leu Tyr Glu Val 
        435                 440                 445             


Lys Ser Glu Asn Leu Gly Gln Gly Asp Lys Pro Asp Tyr Phe Ser Ser 
    450                 455                 460                 


Val Ala Thr Val Val Tyr Leu Arg Lys Glu Asn Cys Met Tyr Gln Ala 
465                 470                 475                 480 


Cys Pro Thr Gln Asp Cys Asn Lys Lys Val Ile Asp Gln Gln Asn Gly 
                485                 490                 495     


Leu Tyr Arg Cys Glu Lys Cys Asp Thr Glu Phe Pro Asn Phe Lys Tyr 
            500                 505                 510         


Arg Met Ile Leu Ser Val Asn Ile Ala Asp Phe Gln Glu Asn Gln Trp 
        515                 520                 525             


Val Thr Cys Phe Gln Glu Ser Ala Glu Ala Ile Leu Gly Gln Asn Ala 
    530                 535                 540                 


Ala Tyr Leu Gly Glu Leu Lys Asp Lys Asn Glu Gln Ala Phe Glu Glu 
545                 550                 555                 560 


Val Phe Gln Asn Ala Asn Phe Arg Ser Phe Ile Phe Arg Val Arg Val 
                565                 570                 575     


Lys Val Glu Thr Tyr Asn Asp Glu Ser Arg Ile Lys Ala Thr Val Met 
            580                 585                 590         


Asp Val Lys Pro Val Asp Tyr Arg Glu Tyr Gly Arg Arg Leu Val Met 
        595                 600                 605             


Ser Ile Arg Arg Ser Ala Leu Met 
    610                 615     


<210>  19
<211>  495
<212>  PRT
<213>  Oxytricha nova


<220>
<221>  domain OB-fold
<222>  (221)..(299)

<400>  19

Met Ser Thr Ala Ala Lys Gln Asn Arg Ser Thr Ser Arg Val Ser Lys 
1               5                   10                  15      


Lys Lys Thr Ala Ala Pro Lys Glu Gly Ala Ala Lys Lys Ser Asp Lys 
            20                  25                  30          


Gly His Lys Tyr Glu Tyr Val Glu Leu Ala Lys Ala Ser Leu Thr Ser 
        35                  40                  45              


Ala Gln Pro Gln His Phe Tyr Ala Val Val Ile Asp Ala Thr Phe Pro 
    50                  55                  60                  


Tyr Lys Thr Asn Gln Glu Arg Tyr Ile Cys Ser Leu Lys Ile Val Asp 
65                  70                  75                  80  


Pro Thr Leu Tyr Leu Lys Gln Gln Lys Gly Ala Gly Asp Ala Ser Asp 
                85                  90                  95      


Tyr Ala Thr Leu Val Leu Tyr Ala Lys Arg Phe Glu Asp Leu Pro Ile 
            100                 105                 110         


Ile His Arg Ala Gly Asp Ile Ile Arg Val His Arg Ala Thr Leu Arg 
        115                 120                 125             


Leu Tyr Asn Gly Gln Arg Gln Phe Asn Ala Asn Val Phe Tyr Ser Ser 
    130                 135                 140                 


Ser Trp Ala Leu Phe Ser Thr Asp Lys Arg Ser Val Thr Gln Glu Ile 
145                 150                 155                 160 


Asn Asn Gln Asp Ala Val Ser Asp Thr Thr Pro Phe Ser Phe Ser Ser 
                165                 170                 175     


Lys His Ala Thr Ile Glu Lys Asn Glu Ile Ser Ile Leu Gln Asn Leu 
            180                 185                 190         


Arg Lys Trp Ala Asn Gln Tyr Phe Ser Ser Tyr Ser Val Ile Ser Ser 
        195                 200                 205             


Asp Met Tyr Thr Ala Leu Asn Lys Ala Gln Ala Gln Lys Gly Asp Phe 
    210                 215                 220                 


Asp Val Val Ala Lys Ile Leu Gln Val His Glu Leu Asp Glu Tyr Thr 
225                 230                 235                 240 


Asn Glu Leu Lys Leu Lys Asp Ala Ser Gly Gln Val Phe Tyr Thr Leu 
                245                 250                 255     


Ser Leu Lys Leu Lys Phe Pro His Val Arg Thr Gly Glu Val Val Arg 
            260                 265                 270         


Ile Arg Ser Ala Thr Tyr Asp Glu Thr Ser Thr Gln Lys Lys Val Leu 
        275                 280                 285             


Ile Leu Ser His Tyr Ser Asn Ile Ile Thr Phe Ile Gln Ser Ser Lys 
    290                 295                 300                 


Leu Ala Lys Glu Leu Arg Ala Lys Ile Gln Asp Asp His Ser Val Glu 
305                 310                 315                 320 


Val Ala Ser Leu Lys Lys Asn Val Ser Leu Asn Ala Val Val Leu Thr 
                325                 330                 335     


Glu Val Asp Lys Lys His Ala Ala Leu Pro Ser Thr Ser Leu Gln Asp 
            340                 345                 350         


Leu Phe His His Ala Asp Ser Asp Lys Glu Leu Gln Ala Gln Asp Thr 
        355                 360                 365             


Phe Arg Thr Gln Phe Tyr Val Thr Lys Ile Glu Pro Ser Asp Val Lys 
    370                 375                 380                 


Glu Trp Val Lys Gly Tyr Asp Arg Lys Thr Lys Lys Ser Ser Ser Leu 
385                 390                 395                 400 


Lys Gly Ala Ser Gly Lys Gly Asp Asn Ile Phe Gln Val Gln Phe Leu 
                405                 410                 415     


Val Lys Asp Ala Ser Thr Gln Leu Asn Asn Asn Thr Tyr Arg Val Leu 
            420                 425                 430         


Leu Tyr Thr Gln Asp Gly Leu Gly Ala Asn Phe Phe Asn Val Lys Ala 
        435                 440                 445             


Asp Asn Leu His Lys Asn Ala Asp Ala Arg Lys Lys Leu Glu Asp Ser 
    450                 455                 460                 


Ala Glu Leu Leu Thr Lys Phe Asn Ser Tyr Val Asp Ala Val Val Glu 
465                 470                 475                 480 


Arg Arg Asn Gly Phe Tyr Leu Ile Lys Asp Thr Lys Leu Ile Tyr 
                485                 490                 495 


<210>  20
<211>  260
<212>  PRT
<213>  Oxytricha nova


<220>
<221>  domain OB-fold
<222>  (36)..(129)

<400>  20

Met Ser Lys Gly Ala Ser Ala Pro Gln Gln Gln Ser Ala Phe Lys Gln 
1               5                   10                  15      


Leu Tyr Thr Glu Leu Phe Asn Asn Glu Gly Asp Phe Ser Lys Val Ser 
            20                  25                  30          


Ser Asn Leu Lys Lys Pro Leu Lys Cys Tyr Val Lys Glu Ser Tyr Pro 
        35                  40                  45              


His Phe Leu Val Thr Asp Gly Tyr Phe Phe Val Ala Pro Tyr Phe Thr 
    50                  55                  60                  


Lys Glu Ala Val Asn Glu Phe His Ala Lys Phe Pro Asn Val Asn Ile 
65                  70                  75                  80  


Val Asp Leu Thr Asp Lys Val Ile Val Ile Asn Asn Trp Ser Leu Glu 
                85                  90                  95      


Leu Arg Arg Val Asn Ser Ala Glu Val Phe Thr Ser Tyr Ala Asn Leu 
            100                 105                 110         


Glu Ala Arg Leu Ile Val His Ser Phe Lys Pro Asn Leu Gln Glu Arg 
        115                 120                 125             


Leu Asn Pro Thr Arg Tyr Pro Val Asn Leu Phe Arg Asp Asp Glu Phe 
    130                 135                 140                 


Lys Thr Thr Ile Gln His Phe Arg His Thr Ala Leu Gln Ala Ala Ile 
145                 150                 155                 160 


Asn Lys Thr Val Lys Gly Asp Asn Leu Val Asp Ile Ser Lys Val Ala 
                165                 170                 175     


Asp Ala Ala Gly Lys Lys Gly Lys Val Asp Ala Gly Ile Val Lys Ala 
            180                 185                 190         


Ser Ala Ser Lys Gly Asp Glu Phe Ser Asp Phe Ser Phe Lys Glu Gly 
        195                 200                 205             


Asn Thr Ala Thr Leu Lys Ile Ala Asp Ile Phe Val Gln Glu Lys Gly 
    210                 215                 220                 


Lys Asp Ala Leu Asn Lys Ala Ala Asp His Thr Asp Gly Ala Lys Val 
225                 230                 235                 240 


Lys Gly Gly Ala Lys Gly Lys Gly Lys Ala Ala Ala Lys Ala Ala Lys 
                245                 250                 255     


Gly Lys Lys Leu 
            260 


<210>  21
<211>  148
<212>  PRT
<213>  Homo sapiens


<220>
<221>  domain OB-fold
<222>  (32)..(148)

<220>
<221>  CONFLICT
<222>  (105)..(105)

<400>  21

Met Phe Arg Arg Pro Val Leu Gln Val Leu Arg Gln Phe Val Arg His 
1               5                   10                  15      


Glu Ser Glu Thr Thr Thr Ser Leu Val Leu Glu Arg Ser Leu Asn Arg 
            20                  25                  30          


Val His Leu Leu Gly Arg Val Gly Gln Asp Pro Val Leu Arg Gln Val 
        35                  40                  45              


Glu Gly Lys Asn Pro Val Thr Ile Phe Ser Leu Ala Thr Asn Glu Met 
    50                  55                  60                  


Trp Arg Ser Gly Asp Ser Glu Val Tyr Gln Leu Gly Asp Val Ser Gln 
65                  70                  75                  80  


Lys Thr Thr Trp His Arg Ile Ser Val Phe Arg Pro Gly Leu Arg Asp 
                85                  90                  95      


Val Ala Tyr Gln Tyr Val Lys Lys Arg Ser Arg Ile Tyr Leu Glu Gly 
            100                 105                 110         


Lys Ile Asp Tyr Gly Glu Tyr Met Asp Lys Asn Asn Val Arg Arg Gln 
        115                 120                 125             


Ala Thr Thr Ile Ile Ala Asp Asn Ile Ile Phe Leu Ser Asp Gln Thr 
    130                 135                 140                 


Lys Glu Lys Glu 
145             


<210>  22
<211>  133
<212>  PRT
<213>  Bordetella pertussis


<220>
<221>  domain OB-fold
<222>  (38)..(126)

<400>  22

Met Gln Arg Gln Ala Gly Leu Pro Leu Lys Ala Asn Pro Met His Thr 
1               5                   10                  15      


Ile Ala Ser Ile Leu Leu Ser Val Leu Gly Ile Tyr Ser Pro Ala Asp 
            20                  25                  30          


Val Ala Gly Leu Pro Thr His Leu Tyr Lys Asn Phe Thr Val Gln Glu 
        35                  40                  45              


Leu Ala Leu Lys Leu Lys Gly Lys Asn Gln Glu Phe Cys Leu Thr Ala 
    50                  55                  60                  


Phe Met Ser Gly Arg Ser Leu Val Arg Ala Cys Leu Ser Asp Ala Gly 
65                  70                  75                  80  


His Glu His Asp Thr Trp Phe Asp Thr Met Leu Gly Phe Ala Ile Ser 
                85                  90                  95      


Ala Tyr Ala Leu Lys Ser Arg Ile Ala Leu Thr Val Glu Asp Ser Pro 
            100                 105                 110         


Tyr Pro Gly Thr Pro Gly Asp Leu Leu Glu Leu Gln Ile Cys Pro Leu 
        115                 120                 125             


Asn Gly Tyr Cys Glu 
    130             


<210>  23
<211>  152
<212>  PRT
<213>  Bordetella pertussis


<220>
<221>  domain OB-fold
<222>  (46)..(144)

<400>  23

Met Leu Arg Arg Phe Pro Thr Arg Thr Thr Ala Pro Gly Gln Gly Gly 
1               5                   10                  15      


Ala Arg Arg Ser Arg Val Arg Ala Leu Ala Trp Leu Leu Ala Ser Gly 
            20                  25                  30          


Ala Met Thr His Leu Ser Pro Ala Leu Ala Asp Val Pro Tyr Val Leu 
        35                  40                  45              


Val Lys Thr Asn Met Val Val Thr Ser Val Ala Met Lys Pro Tyr Glu 
    50                  55                  60                  


Val Thr Pro Thr Arg Met Leu Val Cys Gly Ile Ala Ala Lys Leu Gly 
65                  70                  75                  80  


Ala Ala Ala Ser Ser Pro Asp Ala His Val Pro Phe Cys Phe Gly Lys 
                85                  90                  95      


Asp Leu Lys Arg Pro Gly Ser Ser Pro Met Glu Val Met Leu Arg Ala 
            100                 105                 110         


Val Phe Met Gln Gln Arg Pro Leu Arg Met Phe Leu Gly Pro Lys Gln 
        115                 120                 125             


Leu Thr Phe Glu Gly Lys Pro Ala Leu Glu Leu Ile Arg Met Val Glu 
    130                 135                 140                 


Cys Ser Gly Lys Gln Asp Cys Pro 
145                 150         


<210>  24
<211>  80
<212>  PRT
<213>  Vibrio cholerae


<220>
<221>  domain OB-fold
<222>  (15)..(80)

<400>  24

Met Thr Pro Gln Asn Ile Thr Asp Leu Cys Ala Glu Tyr His Asn Thr 
1               5                   10                  15      


Gln Ile His Thr Leu Asn Asp Lys Ile Phe Ser Tyr Thr Glu Ser Leu 
            20                  25                  30          


Ala Gly Lys Arg Glu Met Ala Ile Ile Thr Phe Lys Asn Gly Ala Thr 
        35                  40                  45              


Phe Gln Val Glu Val Pro Gly Ser Gln His Ile Asp Ser Gln Lys Lys 
    50                  55                  60                  


Ala Ile Glu Arg Met Lys Asp Thr Leu Arg Ile Ala Tyr Leu Thr Glu 
65                  70                  75                  80  


<210>  25
<211>  122
<212>  PRT
<213>  Escherichia coli


<220>
<221>  domain OB-fold
<222>  (37)..(122)

<400>  25

Met Ser Phe Lys Lys Ile Ile Lys Ala Phe Val Ile Met Ala Ala Leu 
1               5                   10                  15      


Val Ser Val Gln Ala His Ala Gly Ala Ser Gln Phe Phe Lys Asp Asn 
            20                  25                  30          


Cys Asn Arg Thr Thr Ala Ser Leu Val Glu Gly Val Glu Leu Thr Lys 
        35                  40                  45              


Tyr Ile Ser Asp Ile Asn Asn Asn Thr Asp Gly Met Tyr Val Val Ser 
    50                  55                  60                  


Ser Thr Gly Gly Val Trp Arg Ile Ser Arg Ala Lys Asp Tyr Pro Asp 
65                  70                  75                  80  


Asn Val Met Thr Ala Glu Met Arg Lys Ile Ala Met Ala Ala Val Leu 
                85                  90                  95      


Ser Gly Met Arg Val Asn Met Cys Ala Ser Pro Ala Ser Ser Pro Asn 
            100                 105                 110         


Val Ile Trp Ala Ile Glu Leu Glu Ala Glu 
        115                 120         


<210>  26
<211>  87
<212>  PRT
<213>  Escherichia coli


<220>
<221>  domain OB-fold
<222>  (20)..(87)

<220>
<221>  CONFLICT
<222>  (83)..(83)

<220>
<221>  CONFLICT
<222>  (85)..(85)

<400>  26

Met Lys Lys Met Phe Ile Ala Val Leu Phe Ala Leu Val Ser Val Asn 
1               5                   10                  15      


Ala Met Ala Ala Asp Cys Ala Lys Gly Lys Ile Glu Phe Ser Lys Tyr 
            20                  25                  30          


Asn Glu Asp Asn Thr Phe Thr Val Lys Val Ser Gly Arg Glu Tyr Trp 
        35                  40                  45              


Thr Asn Arg Trp Asn Leu Gln Pro Leu Leu Gln Ser Ala Gln Leu Thr 
    50                  55                  60                  


Gly Met Thr Val Thr Ile Ile Ser Asn Thr Cys Ser Ser Gly Ser Gly 
65                  70                  75                  80  


Phe Ala Gln Val Lys Phe Asn 
                85          


<210>  27
<211>  220
<212>  PRT
<213>  Homo sapiens


<220>
<221>  domain OB-fold
<222>  (41)..(133)

<400>  27

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Cys Ser Cys Ser Pro Val 
            20                  25                  30          


His Pro Gln Gln Ala Phe Cys Asn Ala Asp Val Val Ile Arg Ala Lys 
        35                  40                  45              


Ala Val Ser Glu Lys Glu Val Asp Ser Gly Asn Asp Ile Tyr Gly Asn 
    50                  55                  60                  


Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys Gln Ile Lys Met Phe Lys 
65                  70                  75                  80  


Gly Pro Glu Lys Asp Ile Glu Phe Ile Tyr Thr Ala Pro Ser Ser Ala 
                85                  90                  95      


Val Cys Gly Val Ser Leu Asp Val Gly Gly Lys Lys Glu Tyr Leu Ile 
            100                 105                 110         


Ala Gly Lys Ala Glu Gly Asp Gly Lys Met His Ile Thr Leu Cys Asp 
        115                 120                 125             


Phe Ile Val Pro Trp Asp Thr Leu Ser Thr Thr Gln Lys Lys Ser Leu 
    130                 135                 140                 


Asn His Arg Tyr Gln Met Gly Cys Glu Cys Lys Ile Thr Arg Cys Pro 
145                 150                 155                 160 


Met Ile Pro Cys Tyr Ile Ser Ser Pro Asp Glu Cys Leu Trp Met Asp 
                165                 170                 175     


Trp Val Thr Glu Lys Asn Ile Asn Gly His Gln Ala Lys Phe Phe Ala 
            180                 185                 190         


Cys Ile Lys Arg Ser Asp Gly Ser Cys Ala Trp Tyr Arg Gly Ala Ala 
        195                 200                 205             


Pro Pro Lys Gln Glu Phe Leu Asp Ile Glu Asp Pro 
    210                 215                 220 


<210>  28
<211>  235
<212>  PRT
<213>  Streptococcus pyogenes


<220>
<221>  domain OB-fold
<222>  (48)..(120)

<400>  28

Met Lys Lys Ile Asn Ile Ile Lys Ile Val Phe Ile Ile Thr Val Ile 
1               5                   10                  15      


Leu Ile Ser Thr Ile Ser Pro Ile Ile Lys Ser Asp Ser Lys Lys Asp 
            20                  25                  30          


Ile Ser Asn Val Lys Ser Asp Leu Leu Tyr Ala Tyr Thr Ile Thr Pro 
        35                  40                  45              


Tyr Asp Tyr Lys Asp Cys Arg Val Asn Phe Ser Thr Thr His Thr Leu 
    50                  55                  60                  


Asn Ile Asp Thr Gln Lys Tyr Arg Gly Lys Asp Tyr Tyr Ile Ser Ser 
65                  70                  75                  80  


Glu Met Ser Tyr Glu Ala Ser Gln Lys Phe Lys Arg Asp Asp His Val 
                85                  90                  95      


Asp Val Phe Gly Leu Phe Tyr Ile Leu Asn Ser His Thr Gly Glu Tyr 
            100                 105                 110         


Ile Tyr Gly Gly Ile Thr Pro Ala Gln Asn Asn Lys Val Asn His Lys 
        115                 120                 125             


Leu Leu Gly Asn Leu Phe Ile Ser Gly Glu Ser Gln Gln Asn Leu Asn 
    130                 135                 140                 


Asn Lys Ile Ile Leu Glu Lys Asp Ile Val Thr Phe Gln Glu Ile Asp 
145                 150                 155                 160 


Phe Lys Ile Arg Lys Tyr Leu Met Asp Asn Tyr Lys Ile Tyr Asp Ala 
                165                 170                 175     


Thr Ser Pro Tyr Val Ser Gly Arg Ile Glu Ile Gly Thr Lys Asp Gly 
            180                 185                 190         


Lys His Glu Gln Ile Asp Leu Phe Asp Ser Pro Asn Glu Gly Thr Arg 
        195                 200                 205             


Ser Asp Ile Phe Ala Lys Tyr Lys Asp Asn Arg Ile Ile Asn Met Lys 
    210                 215                 220                 


Asn Phe Ser His Phe Asp Ile Tyr Leu Glu Lys 
225                 230                 235 


<210>  29
<211>  250
<212>  PRT
<213>  Staphylococcus aureus


<220>
<221>  domain OB-fold
<222>  (41)..(132)

<400>  29

Ile Leu Val Ile Ser Thr Pro Asn Val Leu Ala Glu Ser Gln Pro Asp 
1               5                   10                  15      


Pro Lys Pro Asp Glu Leu His Lys Ser Ser Lys Phe Thr Gly Leu Met 
            20                  25                  30          


Glu Asn Met Lys Val Leu Tyr Asp Asp Asn His Val Ser Ala Ile Asn 
        35                  40                  45              


Val Lys Ser Ile Asp Gln Phe Leu Tyr Phe Asp Leu Ile Tyr Ser Ile 
    50                  55                  60                  


Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn Val Arg Val Glu Phe Lys 
65                  70                  75                  80  


Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp Lys Tyr Val Asp Val Phe 
                85                  90                  95      


Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe Ser Lys Lys Thr Asn Asp 
            100                 105                 110         


Ile Asn Ser His Gln Thr Asp Lys Arg Lys Thr Cys Met Tyr Gly Gly 
        115                 120                 125             


Val Thr Glu His Asn Gly Asn Gln Leu Asp Lys Tyr Arg Ser Ile Thr 
    130                 135                 140                 


Val Arg Val Phe Glu Asp Gly Lys Asn Leu Leu Ser Phe Asp Val Gln 
145                 150                 155                 160 


Thr Asn Lys Lys Lys Val Thr Ala Gln Glu Leu Asp Tyr Leu Thr Arg 
                165                 170                 175     


His Tyr Leu Val Lys Asn Lys Lys Leu Tyr Glu Phe Asn Asn Ser Pro 
            180                 185                 190         


Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu Asn Glu Asn Ser Phe Trp 
        195                 200                 205             


Tyr Asp Met Met Pro Ala Pro Gly Asp Lys Phe Asp Gln Ser Lys Tyr 
    210                 215                 220                 


Leu Met Met Tyr Asn Asp Asn Lys Met Val Asp Ser Lys Asp Val Lys 
225                 230                 235                 240 


Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
                245                 250 


<210>  30
<211>  234
<212>  PRT
<213>  Staphylococcus aureus


<220>
<221>  domain OB-fold
<222>  (57)..(131)

<400>  30

Met Asn Lys Lys Leu Leu Met Ile Phe Phe Ile Val Ser Pro Leu Leu 
1               5                   10                  15      


Leu Ala Thr Ile Ala Thr Asp Phe Thr Pro Val Pro Leu Leu Ser Asn 
            20                  25                  30          


Gln Ile Ile Lys Thr Ala Lys Ala Ser Thr Asn Asp Asn Ile Lys Asp 
        35                  40                  45              


Leu Leu Asp Trp Tyr Ser Ser Gly Ser Asp Thr Phe Thr Asn Ser Glu 
    50                  55                  60                  


Val Leu Asp Asn Ser Leu Gly Ser Met Arg Ile Lys Asn Thr Asp Gly 
65                  70                  75                  80  


Ser Ile Ser Leu Ile Ile Phe Pro Ser Pro Tyr Tyr Ser Pro Ala Phe 
                85                  90                  95      


Thr Lys Gly Glu Lys Val Asp Leu Asn Thr Lys Arg Thr Lys Lys Ser 
            100                 105                 110         


Gln His Thr Ser Glu Gly Thr Tyr Ile His Phe Gln Ile Ser Gly Val 
        115                 120                 125             


Thr Asn Thr Glu Lys Leu Pro Thr Pro Ile Glu Leu Pro Leu Lys Val 
    130                 135                 140                 


Lys Val His Gly Lys Asp Ser Pro Leu Lys Tyr Trp Pro Lys Phe Asp 
145                 150                 155                 160 


Lys Lys Gln Leu Ala Ile Ser Thr Leu Asp Phe Glu Ile Arg His Gln 
                165                 170                 175     


Leu Thr Gln Ile His Gly Leu Tyr Arg Ser Ser Asp Lys Thr Gly Gly 
            180                 185                 190         


Tyr Trp Lys Ile Thr Met Asn Asp Gly Ser Thr Tyr Gln Ser Asp Leu 
        195                 200                 205             


Ser Lys Lys Phe Glu Tyr Asn Thr Glu Lys Pro Pro Ile Asn Ile Asp 
    210                 215                 220                 


Glu Ile Lys Thr Ile Glu Ala Glu Ile Asn 
225                 230                 


<210>  31
<211>  70
<212>  PRT
<213>  Escherichia coli


<220>
<221>  domain OB-fold
<222>  (2)..(70)

<400>  31

Met Ser Gly Lys Met Thr Gly Ile Val Lys Trp Phe Asn Ala Asp Lys 
1               5                   10                  15      


Gly Phe Gly Phe Ile Thr Pro Asp Asp Gly Ser Lys Asp Val Phe Val 
            20                  25                  30          


His Phe Ser Ala Ile Gln Asn Asp Gly Tyr Lys Ser Leu Asp Glu Gly 
        35                  40                  45              


Gln Lys Val Ser Phe Thr Ile Glu Ser Gly Ala Lys Gly Pro Ala Ala 
    50                  55                  60                  


Gly Asn Val Thr Ser Leu 
65                  70  


<210>  32
<211>  138
<212>  PRT
<213>  Pyrobaculum aerophilum


<220>
<221>  domain OB-fold
<222>  (4)..(76)

<400>  32

Met Val Leu Lys Trp Val Met Ser Thr Lys Tyr Val Glu Ala Gly Glu 
1               5                   10                  15      


Leu Lys Glu Gly Ser Tyr Val Val Ile Asp Gly Glu Pro Cys Arg Val 
            20                  25                  30          


Val Glu Ile Glu Lys Ser Lys Thr Gly Lys His Gly Ser Ala Lys Ala 
        35                  40                  45              


Arg Ile Val Ala Val Gly Val Phe Asp Gly Gly Lys Arg Thr Leu Ser 
    50                  55                  60                  


Leu Pro Val Asp Ala Gln Val Glu Val Pro Ile Ile Glu Lys Phe Thr 
65                  70                  75                  80  


Ala Gln Ile Leu Ser Val Ser Gly Asp Val Ile Gln Leu Met Asp Met 
                85                  90                  95      


Arg Asp Tyr Lys Thr Ile Glu Val Pro Met Lys Tyr Val Glu Glu Glu 
            100                 105                 110         


Ala Lys Gly Arg Leu Ala Pro Gly Ala Glu Val Glu Val Trp Gln Ile 
        115                 120                 125             


Leu Asp Arg Tyr Lys Ile Ile Arg Val Lys 
    130                 135             


<210>  33
<211>  711
<212>  PRT
<213>  Escherichia coli


<220>
<221>  domain OB-fold
<222>  (623)..(692)

<400>  33

Met Leu Asn Pro Ile Val Arg Lys Phe Gln Tyr Gly Gln His Thr Val 
1               5                   10                  15      


Thr Leu Glu Thr Gly Met Met Ala Arg Gln Ala Thr Ala Ala Val Met 
            20                  25                  30          


Val Ser Met Asp Asp Thr Ala Val Phe Val Thr Val Val Gly Gln Lys 
        35                  40                  45              


Lys Ala Lys Pro Gly Gln Asp Phe Phe Pro Leu Thr Val Asn Tyr Gln 
    50                  55                  60                  


Glu Arg Thr Tyr Ala Ala Gly Arg Ile Pro Gly Ser Phe Phe Arg Arg 
65                  70                  75                  80  


Glu Gly Arg Pro Ser Glu Gly Glu Thr Leu Ile Ala Arg Leu Ile Asp 
                85                  90                  95      


Arg Pro Ile Arg Pro Leu Phe Pro Glu Gly Phe Val Asn Glu Val Gln 
            100                 105                 110         


Val Ile Ala Thr Val Val Ser Val Asn Pro Gln Val Asn Pro Asp Ile 
        115                 120                 125             


Val Ala Met Ile Gly Ala Ser Ala Ala Leu Ser Leu Ser Gly Ile Pro 
    130                 135                 140                 


Phe Asn Gly Pro Ile Gly Ala Ala Arg Val Gly Tyr Ile Asn Asp Gln 
145                 150                 155                 160 


Tyr Val Leu Asn Pro Thr Gln Asp Glu Leu Lys Glu Ser Lys Leu Asp 
                165                 170                 175     


Leu Val Val Ala Gly Thr Glu Ala Ala Val Leu Met Val Glu Ser Glu 
            180                 185                 190         


Ala Gln Leu Leu Ser Glu Asp Gln Met Leu Gly Ala Val Val Phe Gly 
        195                 200                 205             


His Glu Gln Gln Gln Val Val Ile Gln Asn Ile Asn Glu Leu Val Lys 
    210                 215                 220                 


Glu Ala Gly Lys Pro Arg Trp Asp Trp Gln Pro Glu Pro Val Asn Glu 
225                 230                 235                 240 


Ala Leu Asn Ala Arg Val Ala Ala Leu Ala Glu Ala Arg Leu Ser Asp 
                245                 250                 255     


Ala Tyr Arg Ile Thr Asp Lys Gln Glu Arg Tyr Ala Gln Val Asp Val 
            260                 265                 270         


Ile Lys Ser Glu Thr Ile Ala Thr Leu Leu Ala Glu Asp Glu Thr Leu 
        275                 280                 285             


Asp Glu Asn Glu Leu Gly Glu Ile Leu His Ala Ile Glu Lys Asn Val 
    290                 295                 300                 


Val Arg Ser Arg Val Leu Ala Gly Glu Pro Arg Ile Asp Gly Arg Glu 
305                 310                 315                 320 


Lys Asp Met Ile Arg Gly Leu Asp Val Arg Thr Gly Val Leu Pro Arg 
                325                 330                 335     


Thr His Gly Ser Ala Leu Phe Thr Arg Gly Glu Thr Gln Ala Leu Val 
            340                 345                 350         


Thr Ala Thr Leu Gly Thr Ala Arg Asp Ala Gln Val Leu Asp Glu Leu 
        355                 360                 365             


Met Gly Glu Arg Thr Asp Thr Phe Leu Phe His Tyr Asn Phe Pro Pro 
    370                 375                 380                 


Tyr Ser Val Gly Glu Thr Gly Met Val Gly Ser Pro Lys Arg Arg Glu 
385                 390                 395                 400 


Ile Gly His Gly Arg Leu Ala Lys Arg Gly Val Leu Ala Val Met Pro 
                405                 410                 415     


Asp Met Asp Lys Phe Pro Tyr Thr Val Arg Val Val Ser Glu Ile Thr 
            420                 425                 430         


Glu Ser Asn Gly Ser Ser Ser Met Ala Ser Val Cys Gly Ala Ser Leu 
        435                 440                 445             


Ala Leu Met Asp Ala Gly Val Pro Ile Lys Ala Ala Val Ala Gly Ile 
    450                 455                 460                 


Ala Met Gly Leu Val Lys Glu Gly Asp Asn Tyr Val Val Leu Ser Asp 
465                 470                 475                 480 


Ile Leu Gly Asp Glu Asp His Leu Gly Asp Met Asp Phe Lys Val Ala 
                485                 490                 495     


Gly Ser Arg Asp Gly Ile Ser Ala Leu Gln Met Asp Ile Lys Ile Glu 
            500                 505                 510         


Gly Ile Thr Lys Glu Ile Met Gln Val Ala Leu Asn Gln Ala Lys Gly 
        515                 520                 525             


Ala Arg Leu His Ile Leu Gly Val Met Glu Gln Ala Ile Asn Ala Pro 
    530                 535                 540                 


Arg Gly Asp Ile Ser Glu Phe Ala Pro Arg Ile His Thr Ile Lys Ile 
545                 550                 555                 560 


Asn Pro Asp Lys Ile Lys Asp Val Ile Gly Lys Gly Gly Ser Val Ile 
                565                 570                 575     


Arg Ala Leu Thr Glu Glu Thr Gly Thr Thr Ile Glu Ile Glu Asp Asp 
            580                 585                 590         


Gly Thr Val Lys Ile Ala Ala Thr Asp Gly Glu Lys Ala Lys His Ala 
        595                 600                 605             


Ile Arg Arg Ile Glu Glu Ile Thr Ala Glu Ile Glu Val Gly Arg Val 
    610                 615                 620                 


Tyr Thr Gly Lys Val Thr Arg Ile Val Asp Phe Gly Ala Phe Val Ala 
625                 630                 635                 640 


Ile Gly Gly Gly Lys Glu Gly Leu Val His Ile Ser Gln Ile Ala Asp 
                645                 650                 655     


Lys Arg Val Glu Lys Val Thr Asp Tyr Leu Gln Met Gly Gln Glu Val 
            660                 665                 670         


Pro Val Lys Val Leu Glu Val Asp Arg Gln Gly Arg Ile Arg Leu Ser 
        675                 680                 685             


Ile Lys Glu Ala Thr Glu Gln Ser Gln Pro Ala Ala Ala Pro Glu Ala 
    690                 695                 700                 


Pro Ala Ala Glu Gln Gly Glu 
705                 710     


<210>  34
<211>  144
<212>  PRT
<213>  Homo sapiens


<220>
<221>  domain OB-fold
<222>  (31)..(97)

<400>  34

Met Pro Lys Asn Lys Gly Lys Gly Gly Lys Asn Arg Arg Arg Gly Lys 
1               5                   10                  15      


Asn Glu Asn Glu Ser Glu Lys Arg Glu Leu Val Phe Lys Glu Asp Gly 
            20                  25                  30          


Gln Glu Tyr Ala Gln Val Ile Lys Met Leu Gly Asn Gly Arg Leu Glu 
        35                  40                  45              


Ala Met Cys Phe Asp Gly Val Lys Arg Leu Cys His Ile Arg Gly Lys 
    50                  55                  60                  


Leu Arg Lys Lys Val Trp Ile Asn Thr Ser Asp Ile Ile Leu Val Gly 
65                  70                  75                  80  


Leu Arg Asp Tyr Gln Asp Asn Lys Ala Asp Val Ile Leu Lys Tyr Asn 
                85                  90                  95      


Ala Asp Glu Ala Arg Ser Leu Lys Ala Tyr Gly Glu Leu Pro Glu His 
            100                 105                 110         


Ala Lys Ile Asn Glu Thr Asp Thr Phe Gly Pro Gly Asp Asp Asp Glu 
        115                 120                 125             


Ile Gln Phe Asp Asp Ile Gly Asp Asp Asp Glu Asp Ile Asp Asp Ile 
    130                 135                 140                 


<210>  35
<211>  72
<212>  PRT
<213>  Escherichia coli


<220>
<221>  domain OB-fold
<222>  (5)..(72)

<400>  35

Met Ala Lys Glu Asp Asn Ile Glu Met Gln Gly Thr Val Leu Glu Thr 
1               5                   10                  15      


Leu Pro Asn Thr Met Phe Arg Val Glu Leu Glu Asn Gly His Val Val 
            20                  25                  30          


Thr Ala His Ile Ser Gly Lys Met Arg Lys Asn Tyr Ile Arg Ile Leu 
        35                  40                  45              


Thr Gly Asp Lys Val Thr Val Glu Leu Thr Pro Tyr Asp Leu Ser Lys 
    50                  55                  60                  


Gly Arg Ile Val Phe Arg Ser Arg 
65                  70          


<210>  36
<211>  330
<212>  PRT
<213>  Chlorella virus


<220>
<221>  domain OB-fold
<222>  (238)..(317)

<400>  36

Met Val Pro Pro Thr Ile Asn Thr Gly Lys Asn Ile Thr Thr Glu Arg 
1               5                   10                  15      


Ala Val Leu Thr Leu Asn Gly Leu Gln Ile Lys Leu His Lys Val Val 
            20                  25                  30          


Gly Glu Ser Arg Asp Asp Ile Val Ala Lys Met Lys Asp Leu Ala Met 
        35                  40                  45              


Asp Asp His Lys Phe Pro Arg Leu Pro Gly Pro Asn Pro Val Ser Ile 
    50                  55                  60                  


Glu Arg Lys Asp Phe Glu Lys Leu Lys Gln Asn Lys Tyr Val Val Ser 
65                  70                  75                  80  


Glu Lys Thr Asp Gly Ile Arg Phe Met Met Phe Phe Thr Arg Val Phe 
                85                  90                  95      


Gly Phe Lys Val Cys Thr Ile Ile Asp Arg Ala Met Thr Val Tyr Leu 
            100                 105                 110         


Leu Pro Phe Lys Asn Ile Pro Arg Val Leu Phe Gln Gly Ser Ile Phe 
        115                 120                 125             


Asp Gly Glu Leu Cys Val Asp Ile Val Glu Lys Lys Phe Ala Phe Val 
    130                 135                 140                 


Leu Phe Asp Ala Val Val Val Ser Gly Val Thr Val Ser Gln Met Asp 
145                 150                 155                 160 


Leu Ala Ser Arg Phe Phe Ala Met Lys Arg Ser Leu Lys Glu Phe Lys 
                165                 170                 175     


Asn Val Pro Glu Asp Pro Ala Ile Leu Arg Tyr Lys Glu Trp Ile Pro 
            180                 185                 190         


Leu Glu His Pro Thr Ile Ile Lys Asp His Leu Lys Lys Ala Asn Ala 
        195                 200                 205             


Ile Tyr His Thr Asp Gly Leu Ile Ile Met Ser Val Asp Glu Pro Val 
    210                 215                 220                 


Ile Tyr Gly Arg Asn Phe Asn Leu Phe Lys Leu Lys Pro Gly Thr His 
225                 230                 235                 240 


His Thr Ile Asp Phe Ile Ile Met Ser Glu Asp Gly Thr Ile Gly Ile 
                245                 250                 255     


Phe Asp Pro Asn Leu Arg Lys Asn Val Pro Val Gly Lys Leu Asp Gly 
            260                 265                 270         


Tyr Tyr Asn Lys Gly Ser Ile Val Glu Cys Gly Phe Ala Asp Gly Thr 
        275                 280                 285             


Trp Lys Tyr Ile Gln Gly Arg Ser Asp Lys Asn Gln Ala Asn Asp Arg 
    290                 295                 300                 


Leu Thr Tyr Glu Lys Thr Leu Leu Asn Ile Glu Glu Asn Ile Thr Ile 
305                 310                 315                 320 


Asp Glu Leu Leu Asp Leu Phe Lys Trp Glu 
                325                 330 


<210>  37
<211>  359
<212>  PRT
<213>  Bacteriophage T7


<220>
<221>  CONFLICT
<222>  (2)..(2)

<220>
<221>  domain OB-fold
<222>  (242)..(349)

<400>  37

Met Met Asn Ile Lys Thr Asn Pro Phe Lys Ala Val Ser Phe Val Glu 
1               5                   10                  15      


Ser Ala Ile Lys Lys Ala Leu Asp Asn Ala Gly Tyr Leu Ile Ala Glu 
            20                  25                  30          


Ile Lys Tyr Asp Gly Val Arg Gly Asn Ile Cys Val Asp Asn Thr Ala 
        35                  40                  45              


Asn Ser Tyr Trp Leu Ser Arg Val Ser Lys Thr Ile Pro Ala Leu Glu 
    50                  55                  60                  


His Leu Asn Gly Phe Asp Val Arg Trp Lys Arg Leu Leu Asn Asp Asp 
65                  70                  75                  80  


Arg Cys Phe Tyr Lys Asp Gly Phe Met Leu Asp Gly Glu Leu Met Val 
                85                  90                  95      


Lys Gly Val Asp Phe Asn Thr Gly Ser Gly Leu Leu Arg Thr Lys Trp 
            100                 105                 110         


Thr Asp Thr Lys Asn Gln Glu Phe His Glu Glu Leu Phe Val Glu Pro 
        115                 120                 125             


Ile Arg Lys Lys Asp Lys Val Pro Phe Lys Leu His Thr Gly His Leu 
    130                 135                 140                 


His Ile Lys Leu Tyr Ala Ile Leu Pro Leu His Ile Val Glu Ser Gly 
145                 150                 155                 160 


Glu Asp Cys Asp Val Met Thr Leu Leu Met Gln Glu His Val Lys Asn 
                165                 170                 175     


Met Leu Pro Leu Leu Gln Glu Tyr Phe Pro Glu Ile Glu Trp Gln Ala 
            180                 185                 190         


Ala Glu Ser Tyr Glu Val Tyr Asp Met Val Glu Leu Gln Gln Leu Tyr 
        195                 200                 205             


Glu Gln Lys Arg Ala Glu Gly His Glu Gly Leu Ile Val Lys Asp Pro 
    210                 215                 220                 


Met Cys Ile Tyr Lys Arg Gly Lys Lys Ser Gly Trp Trp Lys Met Lys 
225                 230                 235                 240 


Pro Glu Asn Glu Ala Asp Gly Ile Ile Gln Gly Leu Val Trp Gly Thr 
                245                 250                 255     


Lys Gly Leu Ala Asn Glu Gly Lys Val Ile Gly Phe Glu Val Leu Leu 
            260                 265                 270         


Glu Ser Gly Arg Leu Val Asn Ala Thr Asn Ile Ser Arg Ala Leu Met 
        275                 280                 285             


Asp Glu Phe Thr Glu Thr Val Lys Glu Ala Thr Leu Ser Gln Trp Gly 
    290                 295                 300                 


Phe Phe Ser Pro Tyr Gly Ile Gly Asp Asn Asp Ala Cys Thr Ile Asn 
305                 310                 315                 320 


Pro Tyr Asp Gly Trp Ala Cys Gln Ile Ser Tyr Met Glu Glu Thr Pro 
                325                 330                 335     


Asp Gly Ser Leu Arg His Pro Ser Phe Val Met Phe Arg Gly Thr Glu 
            340                 345                 350         


Asp Asn Pro Gln Glu Lys Met 
        355                 


<210>  38
<211>  242
<212>  PRT
<213>  Staphylococcus aureus


<220>
<221>  domain OB-fold
<222>  (100)..(202)

<220>
<221>  CONFLICT
<222>  (217)..(217)

<400>  38

Arg Leu Ile Leu Lys Leu Thr Lys Lys Lys Glu Val Leu Val Met Thr 
1               5                   10                  15      


Glu Tyr Leu Leu Ser Ala Gly Ile Cys Met Ala Ile Val Ser Ile Leu 
            20                  25                  30          


Leu Ile Gly Met Ala Ile Ser Asn Val Ser Lys Gly Gln Tyr Ala Lys 
        35                  40                  45              


Arg Phe Phe Phe Phe Ala Thr Ser Cys Leu Val Leu Thr Leu Val Val 
    50                  55                  60                  


Val Ser Ser Leu Ser Ser Ser Ala Asn Ala Ser Gln Thr Asp Asn Gly 
65                  70                  75                  80  


Val Asn Arg Ser Gly Ser Glu Asp Pro Thr Val Tyr Ser Ala Thr Ser 
                85                  90                  95      


Thr Lys Lys Leu His Lys Glu Pro Ala Thr Leu Ile Lys Ala Ile Asp 
            100                 105                 110         


Gly Asp Thr Val Lys Leu Met Tyr Lys Gly Gln Pro Met Thr Phe Arg 
        115                 120                 125             


Leu Leu Leu Val Asp Thr Pro Glu Thr Lys His Pro Lys Lys Gly Val 
    130                 135                 140                 


Glu Lys Tyr Gly Pro Glu Ala Ser Ala Phe Thr Lys Lys Met Val Glu 
145                 150                 155                 160 


Asn Ala Lys Lys Ile Glu Val Glu Phe Asp Lys Gly Gln Arg Thr Asp 
                165                 170                 175     


Lys Tyr Gly Arg Gly Leu Ala Tyr Ile Tyr Ala Asp Gly Lys Met Val 
            180                 185                 190         


Asn Glu Ala Leu Val Arg Gln Gly Leu Ala Lys Val Ala Tyr Val Tyr 
        195                 200                 205             


Lys Pro Asn Asn Thr His Glu Gln His Leu Arg Lys Ser Glu Ala Gln 
    210                 215                 220                 


Ala Lys Lys Glu Lys Leu Asn Ile Trp Ser Glu Asp Asn Ala Asp Ser 
225                 230                 235                 240 


Gly Gln 
        


<210>  39
<211>  203
<212>  PRT
<213>  Escherichia coli


<220>
<221>  domain OB-fold
<222>  (2)..(64)

<400>  39

Met Ile Gly Arg Leu Arg Gly Ile Ile Ile Glu Lys Gln Pro Pro Leu 
1               5                   10                  15      


Val Leu Ile Glu Val Gly Gly Val Gly Tyr Glu Val His Met Pro Met 
            20                  25                  30          


Thr Cys Phe Tyr Glu Leu Pro Glu Ala Gly Gln Glu Ala Ile Val Phe 
        35                  40                  45              


Thr His Phe Val Val Arg Glu Asp Ala Gln Leu Leu Tyr Gly Phe Asn 
    50                  55                  60                  


Asn Lys Gln Glu Arg Thr Leu Phe Lys Glu Leu Ile Lys Thr Asn Gly 
65                  70                  75                  80  


Val Gly Pro Lys Leu Ala Leu Ala Ile Leu Ser Gly Met Ser Ala Gln 
                85                  90                  95      


Gln Phe Val Asn Ala Val Glu Arg Glu Glu Val Gly Ala Leu Val Lys 
            100                 105                 110         


Leu Pro Gly Ile Gly Lys Lys Thr Ala Glu Arg Leu Ile Val Glu Met 
        115                 120                 125             


Lys Asp Arg Phe Lys Gly Leu His Gly Asp Leu Phe Thr Pro Ala Ala 
    130                 135                 140                 


Asp Leu Val Leu Thr Ser Pro Ala Ser Pro Ala Thr Asp Asp Ala Glu 
145                 150                 155                 160 


Gln Glu Ala Val Ala Ala Leu Val Ala Leu Gly Tyr Lys Pro Gln Glu 
                165                 170                 175     


Ala Ser Arg Met Val Ser Lys Ile Ala Arg Pro Asp Ala Ser Ser Glu 
            180                 185                 190         


Thr Leu Ile Arg Glu Ala Leu Arg Ala Ala Leu 
        195                 200             


<210>  40
<211>  78
<212>  PRT
<213>  Bacteriophage Pf3


<220>
<221>  domain OB-fold
<222>  (2)..(78)

<220>
<221>  CONFLICT
<222>  (36)..(36)

<400>  40

Met Asn Ile Gln Ile Thr Phe Thr Asp Ser Val Arg Gln Gly Thr Ser 
1               5                   10                  15      


Ala Lys Gly Asn Pro Tyr Thr Phe Gln Glu Gly Phe Leu His Leu Glu 
            20                  25                  30          


Asp Lys Pro Phe Pro Leu Gln Cys Gln Phe Phe Val Glu Ser Val Ile 
        35                  40                  45              


Pro Ala Gly Ser Tyr Gln Val Pro Tyr Arg Ile Asn Val Asn Asn Gly 
    50                  55                  60                  


Arg Pro Glu Leu Ala Phe Asp Phe Lys Ala Met Lys Arg Ala 
65                  70                  75              


<210>  41
<211>  87
<212>  PRT
<213>  Bacteriophage M13


<220>
<221>  domain OB-fold
<222>  (2)..(87)

<220>
<221>  CONFLICT
<222>  (70)..(70)

<400>  41

Met Ile Lys Val Glu Ile Lys Pro Ser Gln Ala Gln Phe Thr Thr Arg 
1               5                   10                  15      


Ser Gly Val Ser Arg Gln Gly Lys Pro Tyr Ser Leu Asn Glu Gln Leu 
            20                  25                  30          


Cys Tyr Val Asp Leu Gly Asn Glu Tyr Pro Val Leu Val Lys Ile Thr 
        35                  40                  45              


Leu Asp Glu Gly Gln Pro Ala Tyr Ala Pro Gly Leu Tyr Thr Val His 
    50                  55                  60                  


Leu Ser Ser Phe Lys Ile Gly Gln Phe Gly Ser Leu Met Ile Asp Arg 
65                  70                  75                  80  


Leu Arg Leu Val Pro Ala Lys 
                85          


<210>  42
<211>  292
<212>  PRT
<213>  Bacteriophage T4


<220>
<221>  domain OB-fold
<222>  (40)..(194)

<400>  42

Met Phe Lys Arg Lys Ser Thr Ala Glu Leu Ala Ala Gln Met Ala Lys 
1               5                   10                  15      


Leu Asn Gly Asn Lys Gly Phe Ser Ser Glu Asp Lys Gly Glu Trp Lys 
            20                  25                  30          


Leu Lys Leu Asp Asn Ala Gly Asn Gly Gln Ala Val Ile Arg Phe Leu 
        35                  40                  45              


Pro Ser Lys Asn Asp Glu Gln Ala Pro Phe Ala Ile Leu Val Asn His 
    50                  55                  60                  


Gly Phe Lys Lys Asn Gly Lys Trp Tyr Ile Glu Thr Cys Ser Ser Thr 
65                  70                  75                  80  


His Gly Asp Tyr Asp Ser Cys Pro Val Cys Gln Tyr Ile Ser Lys Asn 
                85                  90                  95      


Asp Leu Tyr Asn Thr Asp Asn Lys Glu Tyr Ser Leu Val Lys Arg Lys 
            100                 105                 110         


Thr Ser Tyr Trp Ala Asn Ile Leu Val Val Lys Asp Pro Ala Ala Pro 
        115                 120                 125             


Glu Asn Glu Gly Lys Val Phe Lys Tyr Arg Phe Gly Lys Lys Ile Trp 
    130                 135                 140                 


Asp Lys Ile Asn Ala Met Ile Ala Val Asp Val Glu Met Gly Glu Thr 
145                 150                 155                 160 


Pro Val Asp Val Thr Cys Pro Trp Glu Gly Ala Asn Phe Val Leu Lys 
                165                 170                 175     


Val Lys Gln Val Ser Gly Phe Ser Asn Tyr Asp Glu Ser Lys Phe Leu 
            180                 185                 190         


Asn Gln Ser Ala Ile Pro Asn Ile Asp Asp Glu Ser Phe Gln Lys Glu 
        195                 200                 205             


Leu Phe Glu Gln Met Val Asp Leu Ser Glu Met Thr Ser Lys Asp Lys 
    210                 215                 220                 


Phe Lys Ser Phe Glu Glu Leu Asn Thr Lys Phe Gly Gln Val Met Gly 
225                 230                 235                 240 


Thr Ala Val Met Gly Gly Ala Ala Ala Thr Ala Ala Lys Lys Ala Asp 
                245                 250                 255     


Lys Val Ala Asp Asp Leu Asp Ala Phe Asn Val Asp Asp Phe Asn Thr 
            260                 265                 270         


Lys Thr Glu Asp Asp Phe Met Ser Ser Ser Ser Gly Ser Ser Ser Ser 
        275                 280                 285             


Ala Asp Asp Thr 
    290         


<210>  43
<211>  175
<212>  PRT
<213>  Thermus thermophilus


<220>
<221>  domain OB-fold
<222>  (15)..(111)

<400>  43

Met Ala Asn Leu Lys Ser Leu Pro Val Gly Asp Lys Ala Pro Glu Val 
1               5                   10                  15      


Val His Met Val Ile Glu Val Pro Arg Gly Ser Gly Asn Lys Tyr Glu 
            20                  25                  30          


Tyr Asp Pro Asp Leu Gly Ala Ile Lys Leu Asp Arg Val Leu Pro Gly 
        35                  40                  45              


Ala Gln Phe Tyr Pro Gly Asp Tyr Gly Phe Ile Pro Ser Thr Leu Ala 
    50                  55                  60                  


Glu Asp Gly Asp Pro Leu Asp Gly Leu Val Leu Ser Thr Tyr Pro Leu 
65                  70                  75                  80  


Leu Pro Gly Val Val Val Glu Val Arg Val Val Gly Leu Leu Leu Met 
                85                  90                  95      


Glu Asp Glu Lys Gly Gly Asp Ala Lys Val Ile Gly Val Val Ala Glu 
            100                 105                 110         


Asp Gln Arg Leu Asp His Ile Gln Asp Ile Gly Asp Val Pro Glu Gly 
        115                 120                 125             


Val Lys Gln Glu Ile Gln His Phe Phe Glu Thr Tyr Lys Ala Leu Glu 
    130                 135                 140                 


Ala Lys Lys Gly Lys Trp Val Lys Val Thr Gly Trp Arg Asp Arg Lys 
145                 150                 155                 160 


Ala Ala Leu Glu Glu Val Arg Ala Cys Ile Ala Arg Tyr Lys Gly 
                165                 170                 175 


<210>  44
<211>  62
<212>  PRT
<213>  artificial sequence

<220>
<223>  Sac7a protein/carboxy-terminal modified Sac7d species

<400>  44

Met Val Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Val Ser Phe 
            20                  25                  30          


Thr Tyr Asp Asp Asn Gly Lys Thr Gly Arg Gly Ala Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu 
    50                  55                  60          


<210>  45
<211>  59
<212>  PRT
<213>  artificial sequence

<220>
<223>  Sac7b protein/carboxy-terminal modified Sac7d species

<400>  45

Met Val Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Val Ser Phe 
            20                  25                  30          


Thr Tyr Asp Asp Asn Gly Lys Thr Gly Arg Gly Ala Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala 
    50                  55                  


<210>  46
<211>  66
<212>  PRT
<213>  artificial sequence

<220>
<223>  hIgG binding protein


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is any amino acid

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is any amino acid

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is any amino acid

<220>
<221>  VARIANT
<222>  (44)..(44)
<223>  Xaa is any amino acid

<220>
<221>  VARIANT
<222>  (46)..(46)
<223>  Xaa is any amino acid

<220>
<221>  VARIANT
<222>  (46)..(46)
<223>  Xaa is any amino acid

<400>  46

Ser Val Lys Val Lys Phe Xaa Xaa Xaa Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Arg Asp Val Cys Arg Gln Gly Lys Asn Val Lys Phe 
            20                  25                  30          


Leu Tyr Asn Asp Asn Gly Lys Tyr Gly Ala Gly Xaa Val Xaa Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  47
<211>  66
<212>  PRT
<213>  artificial sequence

<220>
<223>  hIgG binding protein

<400>  47

Ser Val Lys Val Lys Phe Leu Leu Asn Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Arg Asp Val Cys Arg Gln Gly Lys Asn Val Lys Phe 
            20                  25                  30          


Leu Tyr Asn Asp Asn Gly Lys Tyr Gly Ala Gly Asn Val Asp Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  48
<211>  66
<212>  PRT
<213>  artificial sequence

<220>
<223>  hIgG binding protein

<400>  48

Ser Val Lys Val Lys Phe Leu Leu Asn Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Arg Asp Val Cys Arg Gln Gly Lys Asn Val Lys Phe 
            20                  25                  30          


Leu Tyr Asn Asp Asn Gly Lys Tyr Gly Ala Gly Lys Val Asn Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  49
<211>  66
<212>  PRT
<213>  artificial sequence

<220>
<223>  hIgG binding protein

<400>  49

Ser Val Lys Val Lys Phe His Ser His Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Arg Asp Val Cys Arg Gln Gly Lys Asn Val Lys Phe 
            20                  25                  30          


Leu Tyr Asn Asp Asn Gly Lys Tyr Gly Ala Gly Asn Val Asp Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  50
<211>  66
<212>  PRT
<213>  artificial sequence

<220>
<223>  hIgG binding protein

<400>  50

Ser Val Lys Val Lys Phe Leu Cys His Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Arg Asp Val Cys Arg Gln Gly Lys Asn Val Lys Phe 
            20                  25                  30          


Leu Tyr Asn Asp Asn Gly Lys Tyr Gly Ala Gly Asn Val Asp Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  51
<211>  66
<212>  PRT
<213>  artificial sequence

<220>
<223>  hIgG binding protein

<400>  51

Ser Val Lys Val Lys Phe Arg Tyr Leu Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Arg Asp Val Cys Arg Gln Gly Lys Asn Val Lys Phe 
            20                  25                  30          


Leu Tyr Asn Asp Asn Gly Lys Tyr Gly Ala Gly Asn Val Asp Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  52
<211>  66
<212>  PRT
<213>  artificial sequence

<220>
<223>  hIgG binding protein

<400>  52

Ser Val Lys Val Lys Phe Ala Arg His Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Arg Asp Val Cys Arg Gln Gly Lys Asn Val Lys Phe 
            20                  25                  30          


Leu Tyr Asn Asp Asn Gly Lys Tyr Gly Ala Gly Asn Val Arg Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  53
<211>  66
<212>  PRT
<213>  artificial sequence

<220>
<223>  hIgG binding protein

<400>  53

Ser Val Lys Val Lys Phe Leu Leu Asn Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Arg Asp Val Cys Arg Gln Gly Lys Asn Val Lys Phe 
            20                  25                  30          


Leu Tyr Asn Asp Asn Gly Lys Tyr Gly Ala Gly Asn Val Asp Glu Lys 
        35                  40                  45              


Asp Val Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  54
<211>  66
<212>  PRT
<213>  artificial sequence

<220>
<223>  hIgG binding protein

<400>  54

Ser Val Lys Val Lys Phe Leu Leu Asn Gly Glu Glu Gln Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Arg Asp Val Cys Arg Gln Gly Lys Asn Val Lys Phe 
            20                  25                  30          


Leu Tyr Asn Asp Asn Gly Lys Tyr Gly Ala Gly Asn Val Asp Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  55
<211>  66
<212>  PRT
<213>  artificial sequence

<220>
<223>  hIgG binding protein

<400>  55

Ser Val Lys Val Lys Phe Leu Leu Asn Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Arg Asp Val Cys Arg Gln Gly Lys Asn Val Lys Phe 
            20                  25                  30          


Leu Tyr Asn Asp Asn Gly Lys Tyr Gly Ala Gly Asn Val Asp Lys Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  56
<211>  66
<212>  PRT
<213>  artificial sequence

<220>
<223>  hIgG binding protein

<400>  56

Ser Val Lys Val Lys Phe Leu Leu Asn Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Arg Asp Val Cys Arg Gln Gly Lys Asn Val Lys Phe 
            20                  25                  30          


Leu Tyr Asn Asp Asn Asp Lys Tyr Gly Ala Gly Asn Val Asp Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  57
<211>  66
<212>  PRT
<213>  artificial sequence

<220>
<223>  hIgG binding protein

<400>  57

Ser Val Lys Val Lys Phe Leu Leu Asn Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Arg Asp Val Cys Arg Gln Gly Lys Asn Val Lys Phe 
            20                  25                  30          


Leu Tyr Asn Asn Asn Gly Lys Tyr Gly Ala Gly Asn Val Asp Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Glu Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  58
<211>  79
<212>  PRT
<213>  artificial sequence

<220>
<223>  H4S

<400>  58

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Phe Trp Asn Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Val 
            20                  25                  30          


Trp Val Lys Arg Ala Gly Lys Ser Val Leu Phe Ile Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Asn Gly Tyr Gly Asp Val Thr Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Asn 
65                  70                  75                  


<210>  59
<211>  79
<212>  PRT
<213>  artificial sequence

<220>
<223>  H4S-W8C

<400>  59

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Phe Cys Asn Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Val 
            20                  25                  30          


Trp Val Lys Arg Ala Gly Lys Ser Val Leu Phe Ile Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Asn Gly Tyr Gly Asp Val Thr Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Asn 
65                  70                  75                  


<210>  60
<211>  79
<212>  PRT
<213>  artificial sequence

<220>
<223>  H4S-V21C

<400>  60

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Phe Trp Asn Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Cys 
            20                  25                  30          


Trp Val Lys Arg Ala Gly Lys Ser Val Leu Phe Ile Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Asn Gly Tyr Gly Asp Val Thr Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Asn 
65                  70                  75                  


<210>  61
<211>  79
<212>  PRT
<213>  artificial sequence

<220>
<223>  H4S-K24C

<400>  61

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Phe Trp Asn Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Val 
            20                  25                  30          


Trp Val Cys Arg Ala Gly Lys Ser Val Leu Phe Ile Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Asn Gly Tyr Gly Asp Val Thr Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Asn 
65                  70                  75                  


<210>  62
<211>  79
<212>  PRT
<213>  artificial sequence

<220>
<223>  H4S-A26C

<400>  62

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Phe Trp Asn Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Val 
            20                  25                  30          


Trp Val Lys Arg Cys Gly Lys Ser Val Leu Phe Ile Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Asn Gly Tyr Gly Asp Val Thr Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Asn 
65                  70                  75                  


<210>  63
<211>  79
<212>  PRT
<213>  artificial sequence

<220>
<223>  H4S-K39C

<400>  63

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Phe Trp Asn Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Val 
            20                  25                  30          


Trp Val Lys Arg Ala Gly Lys Ser Val Leu Phe Ile Tyr Asp Asp Asn 
        35                  40                  45              


Gly Cys Asn Gly Tyr Gly Asp Val Thr Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Asn 
65                  70                  75                  


<210>  64
<211>  3617
<212>  DNA
<213>  artificial sequence

<220>
<223>  pH4S

<400>  64
ctcgagaaat cataaaaaat ttatttgctt tgtgagcgga taacaattat aatagattca       60

attgtgagcg gataacaatt tcacacagaa ttcattaaag aggagaaatt aactatgaga      120

ggatcgcatc accatcacca tcacggatcc gtcaaggtga aattcttctg gaacggcgaa      180

gaaaaagaag tggacactag taagatcgtg tgggttaagc gtgcgggcaa aagtgtgctc      240

tttatctacg acgacaacgg caagaacggt tacggcgacg tgaccgagaa agatgccccg      300

aaagagttat tagatatgtt agcgcgtgcg gaacgcgaga aaaagcttaa ttagctgagc      360

ttggactcct gttgatagat ccagtaatga cctcagaact ccatctggat ttgttcagaa      420

cgctcggttg ccgccgggcg ttttttattg gtgagaatcc aagctagctt ggcgagattt      480

tcaggagcta aggaagctaa aatggagaaa aaaatcactg gatataccac cgttgatata      540

tcccaatggc atcgtaaaga acattttgag gcatttcagt cagttgctca atgtacctat      600

aaccagaccg ttcagctgga tattacggcc tttttaaaga ccgtaaagaa aaataagcac      660

aagttttatc cggcctttat tcacattctt gcccgcctga tgaatgctca tccggaattt      720

cgtatggcaa tgaaagacgg tgagctggtg atatgggata gtgttcaccc ttgttacacc      780

gttttccatg agcaaactga aacgttttca tcgctctgga gtgaatacca cgacgatttc      840

cggcagtttc tacacatata ttcgcaagat gtggcgtgtt acggtgaaaa cctggcctat      900

ttccctaaag ggtttattga gaatatgttt ttcgtctcag ccaatccctg ggtgagtttc      960

accagttttg atttaaacgt ggccaatatg gacaacttct tcgcccccgt tttcaccatg     1020

ggcaaatatt atacgcaagg cgacaaggtg ctgatgccgc tggcgattca ggttcatcat     1080

gccgtttgtg atggcttcca tgtcggcaga atgcttaatg aattacaaca gtactgcgat     1140

gagtggcagg gcggggcgta atttttttaa ggcagttatt ggtgccctta aacgcctggg     1200

gtaatgactc tctagcttga ggcatcaaat aaaacgaaag gctcagtcga aagactgggc     1260

ctttcgtttt atctgttgtt tgtcggtgaa cgctctcctg agtaggacaa atccgccctc     1320

tagagctgcc tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg     1380

gagacggtca cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg     1440

tcagcgggtg ttggcgggtg tcggggcgca gccatgaccc agtcacgtag cgatagcgga     1500

gtgtatactg gcttaactat gcggcatcag agcagattgt actgagagtg caccatatgc     1560

ggtgtgaaat accgcacaga tgcgtaagga gaaaataccg catcaggcgc tcttccgctt     1620

cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact     1680

caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag     1740

caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata     1800

ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc     1860

cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg     1920

ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc     1980

tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg     2040

gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc     2100

ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga     2160

ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg     2220

gctacactag aaggacagta tttggtatct gcgctctgct gaagccagtt accttcggaa     2280

aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg     2340

tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt     2400

ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat     2460

tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct     2520

aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta     2580

tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc gtgtagataa     2640

ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac     2700

gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa     2760

gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag     2820

taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctaca ggcatcgtgg     2880

tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag     2940

ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg     3000

tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg cataattctc     3060

ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat     3120

tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata cgggataata     3180

ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa     3240

aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca     3300

actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc     3360

aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc     3420

tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg     3480

aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac     3540

ctgacgtcta agaaaccatt attatcatga cattaaccta taaaaatagg cgtatcacga     3600

ggccctttcg tcttcac                                                    3617


