                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  SYNTHETIC PEPTIDE INHIBITORS OF WNT PATHWAY

<130>  709396

<150>  US 61/422,857
<151>  2010-12-14

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Lys Lys Arg Leu Ser Val Xaa Leu Thr Ser Ser Leu Phe Arg 
1               5                   10                  


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Xaa Lys Lys Arg Leu Ser Val Xaa Leu Thr Ser Ser Leu Phe Arg 
1               5                   10                  15  


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Xaa Lys Lys Arg Leu Ser Val Xaa Leu Thr Ser Ser Leu Phe Arg Xaa 
1               5                   10                  15      


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<400>  4

Lys Lys Arg Leu Ser Val Xaa Leu Thr Ser Ser Leu Phe Arg Xaa 
1               5                   10                  15  


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Lys Lys Arg Leu Ser Val Xaa Leu Thr Ser Ser Leu Phe Arg Xaa Xaa 
1               5                   10                  15      


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

Xaa Lys Lys Arg Leu Ser Val Xaa Leu Thr Ser Ser Leu Phe Arg Xaa 
1               5                   10                  15      


Xaa 
    


<210>  7
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Lys Lys Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg 
1               5                   10                  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8

Xaa Lys Lys Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg 
1               5                   10                  15  


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<400>  9

Xaa Lys Lys Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Xaa 
1               5                   10                  15      


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<400>  10

Lys Lys Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Xaa 
1               5                   10                  15  


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  Xaa can be any naturally occurring amino acid

<400>  11

Lys Lys Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Xaa Xaa 
1               5                   10                  15      


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Xaa Lys Lys Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Xaa 
1               5                   10                  15      


Xaa 
    


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Lys Lys Arg Leu Ser Val Gln Leu Thr Ser Ser Leu Phe Arg 
1               5                   10                  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Xaa Lys Lys Arg Leu Ser Val Gln Leu Thr Ser Ser Leu Phe Arg 
1               5                   10                  15  


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Xaa Lys Lys Arg Leu Ser Val Gln Leu Thr Ser Ser Leu Phe Arg Xaa 
1               5                   10                  15      


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Lys Lys Arg Leu Ser Val Gln Leu Thr Ser Ser Leu Phe Arg Xaa 
1               5                   10                  15  


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Lys Lys Arg Leu Ser Val Gln Leu Thr Ser Ser Leu Phe Arg Xaa Xaa 
1               5                   10                  15      


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  18

Xaa Lys Lys Arg Leu Ser Val Gln Leu Thr Ser Ser Leu Phe Arg Xaa 
1               5                   10                  15      


Xaa 
    


<210>  19
<211>  60
<212>  PRT
<213>  Mus musculus

<400>  19

Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu Thr Glu Leu Leu 
1               5                   10                  15      


His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala Ala Val Leu Phe 
            20                  25                  30          


Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys Arg Leu Ser Val 
        35                  40                  45              


Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
    50                  55                  60  


<210>  20
<211>  60
<212>  PRT
<213>  Rattus norvegicus

<400>  20

Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu Thr Glu Leu Leu 
1               5                   10                  15      


His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala Ala Val Leu Phe 
            20                  25                  30          


Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys Arg Leu Ser Val 
        35                  40                  45              


Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
    50                  55                  60  


<210>  21
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  21

Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu Thr Glu Leu Leu 
1               5                   10                  15      


His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala Ala Val Leu Phe 
            20                  25                  30          


Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys Arg Leu Ser Val 
        35                  40                  45              


Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
    50                  55                  60  


<210>  22
<211>  60
<212>  PRT
<213>  Bos taurus

<400>  22

Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu Thr Glu Leu Leu 
1               5                   10                  15      


His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala Ala Val Leu Phe 
            20                  25                  30          


Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys Arg Leu Ser Val 
        35                  40                  45              


Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
    50                  55                  60  


<210>  23
<211>  60
<212>  PRT
<213>  Xenopus

<400>  23

Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu Thr Glu Leu Leu 
1               5                   10                  15      


His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala Ala Val Leu Phe 
            20                  25                  30          


Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys Arg Leu Ser Val 
        35                  40                  45              


Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
    50                  55                  60  


<210>  24
<211>  60
<212>  PRT
<213>  Danio rerio

<400>  24

Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu Thr Glu Leu Leu 
1               5                   10                  15      


His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala Ala Val Leu Phe 
            20                  25                  30          


Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys Arg Leu Ser Val 
        35                  40                  45              


Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
    50                  55                  60  


<210>  25
<211>  60
<212>  PRT
<213>  Echinoidea

<400>  25

Glu Met Ile Glu Gln Glu Gly Ala Thr Ala Pro Leu Thr Glu Leu Leu 
1               5                   10                  15      


His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala Ala Val Leu Tyr 
            20                  25                  30          


Arg Met Ser Asp Asp Lys Pro Gln Asp Tyr Lys Lys Arg Ile Ser Val 
        35                  40                  45              


Glu Leu Gly Asn Ser Leu Phe Arg Gly Asp Ser Val 
    50                  55                  60  


<210>  26
<211>  60
<212>  PRT
<213>  Echiura

<400>  26

Glu Met Ile Glu Gln Glu Gly Thr Thr Ala Pro Leu Thr Glu Leu Leu 
1               5                   10                  15      


His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala Ala Val Leu Phe 
            20                  25                  30          


Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys Arg Leu Ser Val 
        35                  40                  45              


Glu Leu Thr Ser Ser Leu Phe Arg Gly Glu Gln Val 
    50                  55                  60  


<210>  27
<211>  60
<212>  PRT
<213>  Drosophila

<400>  27

Glu Ile Ile Glu Gln Glu Gly Ala Thr Gly Pro Leu Thr Asp Leu Leu 
1               5                   10                  15      


His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala Ala Val Leu Phe 
            20                  25                  30          


Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys Arg Leu Ser Ile 
        35                  40                  45              


Glu Leu Thr Asn Ser Leu Leu Arg Glu Asp Asn Asn 
    50                  55                  60  


<210>  28
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is palmitoylated lysine

<400>  28

Xaa Tyr Lys Lys Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg 
1               5                   10                  15      


<210>  29
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is palmitoylated proline

<400>  29

Xaa Gln Asn Tyr Lys Lys Arg Leu Ser Val Glu Leu Thr Ser Ser Leu 
1               5                   10                  15      


Phe Arg 
        


<210>  30
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is palmitoylated tyrosine

<400>  30

Xaa Lys Lys Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg 
1               5                   10                  15  


<210>  31
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is palmitoylated lysine

<400>  31

Xaa Gln Asp Tyr Lys Lys Arg Leu Ser Val Glu Leu Thr Ser Ser Leu 
1               5                   10                  15      


Phe Arg 
        


<210>  32
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is palmitoylated lysine

<400>  32

Xaa Tyr Lys Lys Arg Leu Ser Val Gln Leu Thr Ser Ser Leu Phe Arg 
1               5                   10                  15      


<210>  33
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is 2-dodecyl-alanine

<400>  33

Xaa Tyr Lys Lys Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg 
1               5                   10                  15      


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is acetylated tyrosine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is 2-(4'-pentenyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is 2-(4'-pentenyl)alanine

<400>  34

Xaa Lys Lys Arg Leu Ser Xaa Glu Leu Thr Xaa Ser Leu Phe Arg 
1               5                   10                  15  


<210>  35
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is acetylated arginine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is palmitoylated lysine

<400>  35

Xaa Phe Leu Ser Ser Thr Leu Glu Val Ser Leu Arg Lys Lys Tyr Xaa 
1               5                   10                  15      


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is palmitoylated threonine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is amidated lysine

<400>  36

Xaa Arg Phe Leu Ser Ser Thr Leu Glu Val Ser Leu Arg Lys Xaa 
1               5                   10                  15  


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is palmitoylated threonine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is amidated tyrosine

<400>  37

Xaa Arg Phe Leu Ser Ser Thr Leu Glu Val Ser Leu Arg Lys Lys Xaa 
1               5                   10                  15      


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is palmitoylated amino-isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is amidated tyrosine

<400>  38

Xaa Arg Phe Leu Ser Ser Thr Leu Glu Val Ser Leu Arg Lys Lys Xaa 
1               5                   10                  15      


<210>  39
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is palmitoylated lysine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is amidated lysine

<400>  39

Xaa Thr Arg Phe Leu Ser Ser Thr Leu Glu Val Ser Leu Arg Lys Xaa 
1               5                   10                  15      


<210>  40
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  40

Xaa Xaa Xaa Tyr Lys Lys Arg Leu Ser Val Glu Leu Thr Ser Ser Leu 
1               5                   10                  15      


Phe Arg 
        


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Gln Asp Tyr Lys Lys Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe 
1               5                   10                  15      


Arg 
    


<210>  42
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is any amino acid

<400>  42

Ala Ala Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr 
1               5                   10                  15      


Lys Lys Arg Leu Ser Val Xaa Leu Thr Ser Ser Leu Phe Arg Thr Glu 
            20                  25                  30          


Pro Met Ala Trp Asn 
        35          


