                         SEQUENCE LISTING

<110>  Rinat Neuroscience Corp.
 
<120>  ANTI NOTCH-1 ANTIBODIES

<130>  PC71734A

<150>  61/423,333
<151>  2010-12-15

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  363
<212>  DNA
<213>  Murine adenovirus

<400>  1
caggttcagc tgcagcagtc tggagctgag ctgatgaagc ctggggcctc agtgaagata       60

tcctgcaagg ctactggcta cacattcagt aactactgga tggagtgggt aaagcagagg      120

cctggacatg gccttgagtg gattggagag attttacctg gaaggggtag aactaactac      180

aatgagaact tcaagggcaa ggccacattc actgcagata catcctccaa cacagtctac      240

atgcaactca acagcctgac atctgaggac tctgccgtct attactgtgc aagattccac      300

agctcggcct attactatac tatggactac tggggtcaaa gaacctcggt caccgtctcc      360

tca                                                                    363


<210>  2
<211>  121
<212>  PRT
<213>  Murine adenovirus

<400>  2

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Arg Gly Arg Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe His Ser Ser Ala Tyr Tyr Tyr Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Arg Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  3
<211>  327
<212>  DNA
<213>  Murine adenovirus

<400>  3
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc       60

acttgtcgct caagtactgg ggctgttaca actagtaact atgccaactg ggtccaagaa      120

aaaccagatc atttattcac tggtctaata ggtggtacca acaaccgagc tccaggtatt      180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca      240

cagactgagg atgaggcaat atatttctgt gctctatggt acagcaacca ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  4
<211>  109
<212>  PRT
<213>  Murine adenovirus

<400>  4

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Ile Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  5
<211>  42
<212>  DNA
<213>  Murine adenovirus

<400>  5
cgctcaagta ctggggctgt tacaactagt aactatgcca ac                          42


<210>  6
<211>  21
<212>  DNA
<213>  Murine adenovirus

<400>  6
ggtaccaaca accgagctcc a                                                 21


<210>  7
<211>  27
<212>  DNA
<213>  Murine adenovirus

<400>  7
gctctatggt acagcaacca ctgggtg                                           27


<210>  8
<211>  14
<212>  PRT
<213>  Murine adenovirus

<400>  8

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  9
<211>  7
<212>  PRT
<213>  Murine adenovirus

<400>  9

Gly Thr Asn Asn Arg Ala Pro 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Murine adenovirus

<400>  10

Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  11
<211>  15
<212>  DNA
<213>  Murine adenovirus

<400>  11
aactactgga tggag                                                        15


<210>  12
<211>  51
<212>  DNA
<213>  Murine adenovirus

<400>  12
gagattttac ctggaagggg tagaactaac tacaatgaga acttcaaggg c                51


<210>  13
<211>  36
<212>  DNA
<213>  Murine adenovirus

<400>  13
ttccacagct cggcctatta ctatactatg gactac                                 36


<210>  14
<211>  5
<212>  PRT
<213>  Murine adenovirus

<400>  14

Asn Tyr Trp Met Glu 
1               5   


<210>  15
<211>  17
<212>  PRT
<213>  Murine adenovirus

<400>  15

Glu Ile Leu Pro Gly Arg Gly Arg Thr Asn Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  12
<212>  PRT
<213>  Murine adenovirus

<400>  16

Phe His Ser Ser Ala Tyr Tyr Tyr Thr Met Asp Tyr 
1               5                   10          


<210>  17
<211>  109
<212>  PRT
<213>  Murine adenovirus

<400>  17

Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Leu Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Ala Leu Trp Val Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 


<210>  18
<211>  121
<212>  PRT
<213>  Murine adenovirus

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Arg Pro Phe Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe His Ser Ser Ala Tyr Ala Tyr Arg Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  19
<211>  14
<212>  PRT
<213>  Murine adenovirus

<400>  19

Arg Leu Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  20
<211>  7
<212>  PRT
<213>  Murine adenovirus

<400>  20

Gly Thr Asn Asn Arg Ala Pro 
1               5           


<210>  21
<211>  9
<212>  PRT
<213>  Murine adenovirus

<400>  21

Ala Leu Trp Val Ser Asn His Trp Val 
1               5                   


<210>  22
<211>  5
<212>  PRT
<213>  Murine adenovirus

<400>  22

Asn Tyr Trp Met Glu 
1               5   


<210>  23
<211>  7
<212>  PRT
<213>  Murine adenovirus

<400>  23

Gly Tyr Thr Phe Ser Asn Tyr 
1               5           


<210>  24
<211>  10
<212>  PRT
<213>  Murine adenovirus

<400>  24

Gly Tyr Thr Phe Ser Asn Tyr Trp Met Glu 
1               5                   10  


<210>  25
<211>  17
<212>  PRT
<213>  Murine adenovirus

<400>  25

Glu Ile Leu Pro Gly Arg Pro Phe Thr Asn Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  26
<211>  6
<212>  PRT
<213>  Murine adenovirus

<400>  26

Leu Pro Gly Arg Pro Phe 
1               5       


<210>  27
<211>  12
<212>  PRT
<213>  Murine adenovirus

<400>  27

Phe His Ser Ser Ala Tyr Ala Tyr Arg Met Asp Tyr 
1               5                   10          


<210>  28
<211>  327
<212>  DNA
<213>  Murine adenovirus

<400>  28
cagactgtgg tgacccagga gccttctttc agcgtgtccc ctgggggcac tgtgactctg       60

acctgcaggc tgtctaccgg tgctgtgact acatccaact atgctaattg ggtccagcag      120

accccagggc aggctccacg gggcctgatc ggtggcacca acaacagggc tcctggagtc      180

cccgacaggt tcagcggttc catcctgggc aacaaggccg ccctgaccat cacaggcgct      240

caggccgacg atgaatctga ttactattgc gccctgtggg tgtccaacca ttgggtgttt      300

ggcaccggca ccaaggtgac cgtgctg                                          327


<210>  29
<211>  42
<212>  DNA
<213>  Murine adenovirus

<400>  29
aggctgtcta ccggtgctgt gactacatcc aactatgcta at                          42


<210>  30
<211>  21
<212>  DNA
<213>  Murine adenovirus

<400>  30
ggcaccaaca acagggctcc t                                                 21


<210>  31
<211>  27
<212>  DNA
<213>  Murine adenovirus

<400>  31
gccctgtggg tgtccaacca ttgggtg                                           27


<210>  32
<211>  363
<212>  DNA
<213>  Murine adenovirus

<400>  32
gaggtccagc tggtcgagag tggcggtggg ctggtccagc caggtggaag cctgcgcctc       60

tcttgtgctg ctagcgggta cacattttcc aactactgga tggaatgggt ccgccaggct      120

cccgggaagg gcctcgaatg gatcggtgag atcctgccag gacgaccctt caccaactat      180

aacgaaaatt ttaagggccg gtttaccatc agtgcagaca atgccaagaa ctctctgtac      240

ctgcagatga acagcctgag agccgaagat accgcagtgt attactgtgc caggttccat      300

agcagcgcat atgcttacag gatggactat tgggggcagg gcacaacggt caccgtctcc      360

tca                                                                    363


<210>  33
<211>  15
<212>  DNA
<213>  Murine adenovirus

<400>  33
aactactgga tggaa                                                        15


<210>  34
<211>  51
<212>  DNA
<213>  Murine adenovirus

<400>  34
gagatcctgc caggacgacc cttcaccaac tataacgaaa attttaaggg c                51


<210>  35
<211>  36
<212>  DNA
<213>  Murine adenovirus

<400>  35
ttccatagca gcgcatatgc ttacaggatg gactat                                 36


<210>  36
<211>  215
<212>  PRT
<213>  Murine adenovirus

<400>  36

Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Leu Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Ala Leu Trp Val Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  37
<211>  447
<212>  PRT
<213>  Murine adenovirus

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Arg Pro Phe Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe His Ser Ser Ala Tyr Ala Tyr Arg Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  38
<211>  42
<212>  PRT
<213>  Murine adenovirus

<400>  38

Ala Cys Glu Leu Pro Glu Cys Gln Glu Asp Ala Gly Asn Lys Val Cys 
1               5                   10                  15      


Ser Leu Gln Cys Asn Asn His Ala Cys Gly Trp Asp Gly Gly Asp Cys 
            20                  25                  30          


Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
        35                  40          


<210>  39
<211>  42
<212>  PRT
<213>  Murine adenovirus

<400>  39

Ala Cys Glu Leu Pro Glu Cys Gln Val Asp Ala Gly Asn Lys Val Cys 
1               5                   10                  15      


Asn Leu Gln Cys Asn Asn His Ala Cys Gly Trp Asp Gly Gly Asp Cys 
            20                  25                  30          


Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
        35                  40          


<210>  40
<211>  42
<212>  PRT
<213>  Murine adenovirus

<400>  40

Ala Cys Glu Leu Pro Glu Cys Gln Ala Asp Ala Gly Asn Lys Val Cys 
1               5                   10                  15      


Ser Leu Gln Cys Asn Asn His Ala Cys Gly Trp Asp Gly Gly Asp Cys 
            20                  25                  30          


Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
        35                  40          


<210>  41
<211>  42
<212>  PRT
<213>  Murine adenovirus

<400>  41

Ala Cys Glu Leu Pro Glu Cys Gln Glu Asp Ala Gly Asn Ala Val Cys 
1               5                   10                  15      


Ser Leu Gln Cys Asn Asn His Ala Cys Gly Trp Asp Gly Gly Asp Cys 
            20                  25                  30          


Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
        35                  40          


<210>  42
<211>  42
<212>  PRT
<213>  Murine adenovirus

<400>  42

Ala Cys Glu Leu Pro Glu Cys Gln Glu Asp Ala Gly Asn Lys Ala Cys 
1               5                   10                  15      


Ser Leu Gln Cys Asn Asn His Ala Cys Gly Trp Asp Gly Gly Asp Cys 
            20                  25                  30          


Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
        35                  40          


<210>  43
<211>  42
<212>  PRT
<213>  Murine adenovirus

<400>  43

Ala Cys Glu Leu Pro Glu Cys Gln Glu Asp Ala Gly Asn Lys Val Cys 
1               5                   10                  15      


Asn Leu Gln Cys Asn Asn His Ala Cys Gly Trp Asp Gly Gly Asp Cys 
            20                  25                  30          


Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
        35                  40          


<210>  44
<211>  42
<212>  PRT
<213>  Murine adenovirus

<400>  44

Ala Cys Glu Leu Pro Glu Cys Gln Glu Asp Ala Gly Asn Lys Val Cys 
1               5                   10                  15      


Ser Ala Gln Cys Asn Asn His Ala Cys Gly Trp Asp Gly Gly Asp Cys 
            20                  25                  30          


Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
        35                  40          


<210>  45
<211>  42
<212>  PRT
<213>  Murine adenovirus

<400>  45

Ala Cys Glu Leu Pro Glu Cys Gln Glu Asp Ala Gly Asn Lys Val Cys 
1               5                   10                  15      


Ser Leu Ala Cys Asn Asn His Ala Cys Gly Trp Asp Gly Gly Asp Cys 
            20                  25                  30          


Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
        35                  40          


<210>  46
<211>  35
<212>  PRT
<213>  Murine adenovirus

<400>  46

Phe Leu Gly Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys 
1               5                   10                  15      


Ile Glu Ala Val Gln Ser Glu Thr Val Glu Pro Pro Pro Pro Ala Gln 
            20                  25                  30          


Lys Arg Arg 
        35  


<210>  47
<211>  9
<212>  PRT
<213>  Murine adenovirus

<400>  47

Phe Leu Ala Ser His Ala Ile Gln Gly 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  Murine adenovirus

<400>  48

Gly Thr Leu Asn Ile Ser Tyr Pro Ile 
1               5                   


<210>  49
<211>  8
<212>  PRT
<213>  Murine adenovirus

<400>  49

Lys Leu Val Ser Val Val Ser Glu 
1               5               


<210>  50
<211>  7
<212>  PRT
<213>  Murine adenovirus

<400>  50

Glu Ser Leu Glu Thr Pro Pro 
1               5           


<210>  51
<211>  8
<212>  PRT
<213>  Murine adenovirus

<400>  51

Pro Glu Arg Thr Gln Lys Ser Arg 
1               5               


