                         SEQUENCE LISTING

<110>  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
       (INSERM)
 
<120>  NUCLEIC ACIDS TARGETING TCTP FOR USE IN THE TREATMENT OF CANCER

<130>  BEX 10P1296

<150>  EP10306447.3
<151>  2010-12-17

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ile Ile Tyr Arg Asp Leu Ile Ser His Asp Glu Met Phe Ser Asp 
1               5                   10                  15      


Ile Tyr Lys Ile Arg Glu Ile Ala Asp Gly Leu Cys Leu Glu Val Glu 
            20                  25                  30          


Gly Lys Met Val Ser Arg Thr Glu Gly Asn Ile Asp Asp Ser Leu Ile 
        35                  40                  45              


Gly Gly Asn Ala Ser Ala Glu Gly Pro Glu Gly Glu Gly Thr Glu Ser 
    50                  55                  60                  


Thr Val Ile Thr Gly Val Asp Ile Val Met Asn His His Leu Gln Glu 
65                  70                  75                  80  


Thr Ser Phe Thr Lys Glu Ala Tyr Lys Lys Tyr Ile Lys Asp Tyr Met 
                85                  90                  95      


Lys Ser Ile Lys Gly Lys Leu Glu Glu Gln Arg Pro Glu Arg Val Lys 
            100                 105                 110         


Pro Phe Met Thr Gly Ala Ala Glu Gln Ile Lys His Ile Leu Ala Asn 
        115                 120                 125             


Phe Lys Asn Tyr Gln Phe Phe Ile Gly Glu Asn Met Asn Pro Asp Gly 
    130                 135                 140                 


Met Val Ala Leu Leu Asp Tyr Arg Glu Asp Gly Val Thr Pro Tyr Met 
145                 150                 155                 160 


Ile Phe Phe Lys Asp Gly Leu Glu Met Glu Lys Cys 
                165                 170         


<210>  2
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  2
accaatgagc gagtcatcaa                                                   20


<210>  3
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA targeting TCTP

<400>  3
aacccguccg cgaucucccg g                                                 21


<210>  4
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  scrambled oligonucleotide

<400>  4
cgtgtaggta cggcagatc                                                    19


<210>  5
<211>  829
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (153)..(173)
<223>  Region targeted by the siRNA of SEQ ID NO: 3

<220>
<221>  misc_feature
<222>  (221)..(240)
<223>  Region targeted by the antisense oligonucleotide of SEQ ID NO: 2

<400>  5
ccccccgagc gccgctccgg ctgcaccgcg ctcgctccga gtttcaggct cgtgctaagc       60

tagcgccgtc gtcgtctccc ttcagtcgcc atcatgatta tctaccggga cctcatcagc      120

cacgatgaga tgttctccga catctacaag atccgggaga tcgcggacgg gttgtgcctg      180

gaggtggagg ggaagatggt cagtaggaca gaaggtaaca ttgatgactc gctcattggt      240

ggaaatgcct ccgctgaagg ccccgagggc gaaggtaccg aaagcacagt aatcactggt      300

gtcgatattg tcatgaacca tcacctgcag gaaacaagtt tcacaaaaga agcctacaag      360

aagtacatca aagattacat gaaatcaatc aaagggaaac ttgaagaaca gagaccagaa      420

agagtaaaac cttttatgac aggggctgca gaacaaatca agcacatcct tgctaatttc      480

aaaaactacc agttctttat tggtgaaaac atgaatccag atggcatggt tgctctattg      540

gactaccgtg aggatggtgt gaccccatat atgattttct ttaaggatgg tttagaaatg      600

gaaaaatgtt aacaaatgtg gcaattattt tggatctatc acctgtcatc ataactggct      660

tctgcttgtc atccacacaa caccaggact taagacaaat gggactgatg tcatcttgag      720

ctcttcattt attttgactg tgatttattt ggagtggagg cattgttttt aagaaaaaca      780

tgtcatgtag gttgtctaaa aataaaatgc atttaaactc atttgagag                  829


<210>  6
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  6
aaccccggat cggactacta                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  7
aataagctct agagggccgc                                                   20


<210>  8
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  8
gaaagcacag taatcactgg tgt                                               23


<210>  9
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  9
gcagcccctg tcataaaagg t                                                 21


<210>  10
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  10
ctaccacatc caaggaaggc                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  11
ttttcgtcac tacctccccg                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  12
gggacgcggc gctcggtcat                                                   20


<210>  13
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  13
cagcagcaga gtatttatca t                                                 21


<210>  14
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  14
aacttgtttc ctgcaggtga                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  15
tggttcatga caatatcgac                                                   20


<210>  16
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Thr Glu Arg Arg Val Pro Phe Ser Leu Leu Arg Gly Pro Ser Trp 
1               5                   10                  15      


Asp Pro Phe Arg Asp Trp Tyr Pro His Ser Arg Leu Phe Asp Gln Ala 
            20                  25                  30          


Phe Gly Leu Pro Arg Leu Pro Glu Glu Trp Ser Gln Trp Leu Gly Gly 
        35                  40                  45              


Ser Ser Trp Pro Gly Tyr Val Arg Pro Leu Pro Pro Ala Ala Ile Glu 
    50                  55                  60                  


Ser Pro Ala Val Ala Ala Pro Ala Tyr Ser Arg Ala Leu Ser Arg Gln 
65                  70                  75                  80  


Leu Ser Ser Gly Val Ser Glu Ile Arg His Thr Ala Asp Arg Trp Arg 
                85                  90                  95      


Val Ser Leu Asp Val Asn His Phe Ala Pro Asp Glu Arg Thr Val Lys 
            100                 105                 110         


Thr Lys Asp Gly Val Val Glu Ile Ser Gly Lys His Glu Glu Leu Gln 
        115                 120                 125             


Asp Glu His Gly Tyr Ile Ser Arg Cys Phe Thr Arg Lys Tyr Thr Leu 
    130                 135                 140                 


Pro Pro Gly Val Asp Pro Thr Gln Val Ser Ser Ser Leu Ser Pro Glu 
145                 150                 155                 160 


Gly Thr Leu Thr Val Glu Ala Pro Met Pro Lys Leu Ala Thr Gln Ser 
                165                 170                 175     


Asn Glu Ile Thr Ile Pro Val Thr Phe Glu Ser Arg Ala Gln Leu Gly 
            180                 185                 190         


Gly Pro Glu Ala Ala Lys Ser Asp Glu Thr Ala Ala Lys 
        195                 200                 205 


<210>  17
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  17
taatcatgat ggcgactgaa                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  18
gctgatgagg tcccggtaga                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  19
tcggagaaca tctcatcgtg                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  20
caggcacaac ccgtccgcga                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  21
accatcttcc cctccacctc                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  22
tgttaccttc tgtcctactg                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  23
ccttcagcgg aggcatttcc                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  24
cagtaccttc gccctcgggg                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  25
accagtgatt actgtgcttt                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  26
cttgtaggct tcttttgtga                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  27
atgtaatctt tgatgtactt                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  28
gtttcccttt gattgatttc                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  29
ttctggtctc tgttcttcaa                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  30
ataaagaact ggtagttttt                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  31
ctggattcat gttttcacca                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  32
caatagagca accatgccat                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  33
acaccatcct cacggtagtc                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  34
agaaaatcat atatggggtc                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  35
catttctaaa ccatccttaa                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  36
ttaacatttc tccatttcta                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  37
tctcccggat cttgtagatg                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  38
gtcataaaag gttttactct                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  39
tgatttgttc tgcagcccct                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  40
gaaattagca aggatgtgct                                                   20


