                         SEQUENCE LISTING

<110>  PharmaZell GmbH
 
<120>  Neuartige 7beta-Hydroxysteroid Dehydrogenase-Mutanten und  
       Verfahren zur Herstellung von Ursodesoxycholsure

<130>  M/51187-PCT

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  792
<212>  DNA
<213>  Collinsella aerofaciens


<220>
<221>  CDS
<222>  (1)..(792)

<400>  1
atg aac ctg agg gag aag tac ggt gag tgg ggc ctg atc ctg ggc gcg         48
Met Asn Leu Arg Glu Lys Tyr Gly Glu Trp Gly Leu Ile Leu Gly Ala           
1               5                   10                  15                

acc gag ggc gtc ggc aag gcg ttc tgc gag aag atc gcc gcc ggc ggc         96
Thr Glu Gly Val Gly Lys Ala Phe Cys Glu Lys Ile Ala Ala Gly Gly           
            20                  25                  30                    

atg aac gtc gtc atg gtc ggc cgt cgc gag gag aag ctg aac gtg ctc        144
Met Asn Val Val Met Val Gly Arg Arg Glu Glu Lys Leu Asn Val Leu           
        35                  40                  45                        

gca ggc gag atc cgc gag acc tac ggc gtg gag acc aag gtc gtg cgc        192
Ala Gly Glu Ile Arg Glu Thr Tyr Gly Val Glu Thr Lys Val Val Arg           
    50                  55                  60                            

gcc gac ttt agc cag ccc ggc gct gcc gag acc gtc ttc gcc gcg acc        240
Ala Asp Phe Ser Gln Pro Gly Ala Ala Glu Thr Val Phe Ala Ala Thr           
65                  70                  75                  80            

gag ggc ctg gac atg ggc ttc atg agc tac gtg gcc tgc ctg cac agc        288
Glu Gly Leu Asp Met Gly Phe Met Ser Tyr Val Ala Cys Leu His Ser           
                85                  90                  95                

ttc ggt aag atc cag gac acc ccc tgg gag aag cac gag gcc atg atc        336
Phe Gly Lys Ile Gln Asp Thr Pro Trp Glu Lys His Glu Ala Met Ile           
            100                 105                 110                   

aac gtc aac gtc gtg acc ttc ctc aag tgc ttc cac cac tac atg cgg        384
Asn Val Asn Val Val Thr Phe Leu Lys Cys Phe His His Tyr Met Arg           
        115                 120                 125                       

atc ttt gcc gcc cag gac cgc ggc gcc gtg atc aac gtc tcg tcg atg        432
Ile Phe Ala Ala Gln Asp Arg Gly Ala Val Ile Asn Val Ser Ser Met           
    130                 135                 140                           

acc ggc atc agc tcc agc ccc tgg aac ggc cag tac ggc gcg ggc aag        480
Thr Gly Ile Ser Ser Ser Pro Trp Asn Gly Gln Tyr Gly Ala Gly Lys           
145                 150                 155                 160           

gcc ttc atc ctc aag atg acc gag gcc gtg gcc tgc gag tgc gag ggc        528
Ala Phe Ile Leu Lys Met Thr Glu Ala Val Ala Cys Glu Cys Glu Gly           
                165                 170                 175               

acc ggc gtc gac gtc gag gtc atc acc ctc ggc acc acc cta acc ccc        576
Thr Gly Val Asp Val Glu Val Ile Thr Leu Gly Thr Thr Leu Thr Pro           
            180                 185                 190                   

agc ctg ctg tcc aac ctc ccc ggc ggc ccg cag ggc gag gcc gtc atg        624
Ser Leu Leu Ser Asn Leu Pro Gly Gly Pro Gln Gly Glu Ala Val Met           
        195                 200                 205                       

aag atc gcc ctc acc ccc gag gag tgc gtt gac gag gcc ttt gag aag        672
Lys Ile Ala Leu Thr Pro Glu Glu Cys Val Asp Glu Ala Phe Glu Lys           
    210                 215                 220                           

ctg ggt aag gag ctc tcc gtc atc gcc ggc cag cgc aac aag gac tcc        720
Leu Gly Lys Glu Leu Ser Val Ile Ala Gly Gln Arg Asn Lys Asp Ser           
225                 230                 235                 240           

gtc cac gac tgg aag gca aac cac acc gag gac gag tac atc cgc tac        768
Val His Asp Trp Lys Ala Asn His Thr Glu Asp Glu Tyr Ile Arg Tyr           
                245                 250                 255               

atg ggg tcg ttc tac cgc gac tag                                        792
Met Gly Ser Phe Tyr Arg Asp                                               
            260                                                           


<210>  2
<211>  263
<212>  PRT
<213>  Collinsella aerofaciens

<400>  2

Met Asn Leu Arg Glu Lys Tyr Gly Glu Trp Gly Leu Ile Leu Gly Ala 
1               5                   10                  15      


Thr Glu Gly Val Gly Lys Ala Phe Cys Glu Lys Ile Ala Ala Gly Gly 
            20                  25                  30          


Met Asn Val Val Met Val Gly Arg Arg Glu Glu Lys Leu Asn Val Leu 
        35                  40                  45              


Ala Gly Glu Ile Arg Glu Thr Tyr Gly Val Glu Thr Lys Val Val Arg 
    50                  55                  60                  


Ala Asp Phe Ser Gln Pro Gly Ala Ala Glu Thr Val Phe Ala Ala Thr 
65                  70                  75                  80  


Glu Gly Leu Asp Met Gly Phe Met Ser Tyr Val Ala Cys Leu His Ser 
                85                  90                  95      


Phe Gly Lys Ile Gln Asp Thr Pro Trp Glu Lys His Glu Ala Met Ile 
            100                 105                 110         


Asn Val Asn Val Val Thr Phe Leu Lys Cys Phe His His Tyr Met Arg 
        115                 120                 125             


Ile Phe Ala Ala Gln Asp Arg Gly Ala Val Ile Asn Val Ser Ser Met 
    130                 135                 140                 


Thr Gly Ile Ser Ser Ser Pro Trp Asn Gly Gln Tyr Gly Ala Gly Lys 
145                 150                 155                 160 


Ala Phe Ile Leu Lys Met Thr Glu Ala Val Ala Cys Glu Cys Glu Gly 
                165                 170                 175     


Thr Gly Val Asp Val Glu Val Ile Thr Leu Gly Thr Thr Leu Thr Pro 
            180                 185                 190         


Ser Leu Leu Ser Asn Leu Pro Gly Gly Pro Gln Gly Glu Ala Val Met 
        195                 200                 205             


Lys Ile Ala Leu Thr Pro Glu Glu Cys Val Asp Glu Ala Phe Glu Lys 
    210                 215                 220                 


Leu Gly Lys Glu Leu Ser Val Ile Ala Gly Gln Arg Asn Lys Asp Ser 
225                 230                 235                 240 


Val His Asp Trp Lys Ala Asn His Thr Glu Asp Glu Tyr Ile Arg Tyr 
                245                 250                 255     


Met Gly Ser Phe Tyr Arg Asp 
            260             


<210>  3
<211>  31
<212>  DNA
<213>  artificial

<220>
<223>  PCR Primer

<400>  3
gggaattcca tatgaacctg agggagaagt a                                      31


<210>  4
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  4
cccaagcttc tagtcgcggt agaacga                                           27


<210>  5
<211>  774
<212>  DNA
<213>  Comamonas testosteroni


<220>
<221>  CDS
<222>  (1)..(774)

<400>  5
atg tcc atc atc gtg ata agc ggc tgc gcc acc ggc att ggt gcc gct         48
Met Ser Ile Ile Val Ile Ser Gly Cys Ala Thr Gly Ile Gly Ala Ala           
1               5                   10                  15                

acg cgc aag gtc ctg gag gcg gcc ggt cac cag atc gta ggc atc gat         96
Thr Arg Lys Val Leu Glu Ala Ala Gly His Gln Ile Val Gly Ile Asp           
            20                  25                  30                    

ata cgc gat gcg gaa gtg att gcc gat ctc tcg acg gcc gaa ggt cga        144
Ile Arg Asp Ala Glu Val Ile Ala Asp Leu Ser Thr Ala Glu Gly Arg           
        35                  40                  45                        

aag cag gcg att gcc gat gta ctg gcg aag tgc agc aag ggc atg gac        192
Lys Gln Ala Ile Ala Asp Val Leu Ala Lys Cys Ser Lys Gly Met Asp           
    50                  55                  60                            

ggc ctg gtg ctg tgc gcc ggc ctg gga ccg cag acc aag gtg ctt ggc        240
Gly Leu Val Leu Cys Ala Gly Leu Gly Pro Gln Thr Lys Val Leu Gly           
65                  70                  75                  80            

aat gtg gtt tcg gtc aat tat ttt ggc gcg acc gag ctg atg gat gcc        288
Asn Val Val Ser Val Asn Tyr Phe Gly Ala Thr Glu Leu Met Asp Ala           
                85                  90                  95                

ttt ttg cca gcg ctg aaa aaa ggc cat cag ccc gca gcc gtc gtc atc        336
Phe Leu Pro Ala Leu Lys Lys Gly His Gln Pro Ala Ala Val Val Ile           
            100                 105                 110                   

tcg tcc gtg gct tcc gcg cat ctg gct ttt gac aag aac cca ctg gcg        384
Ser Ser Val Ala Ser Ala His Leu Ala Phe Asp Lys Asn Pro Leu Ala           
        115                 120                 125                       

ctg gca ctg gaa gcc ggc gag gaa gcc aag gcc cgc gcc att gtc gaa        432
Leu Ala Leu Glu Ala Gly Glu Glu Ala Lys Ala Arg Ala Ile Val Glu           
    130                 135                 140                           

cat gcg gga gag cag ggc gga aat ctg gcc tat gcg ggc agc aag aat        480
His Ala Gly Glu Gln Gly Gly Asn Leu Ala Tyr Ala Gly Ser Lys Asn           
145                 150                 155                 160           

gct ttg acg gtg gct gtg cgc aaa cgc gcc gcc gcc tgg ggc gag gct        528
Ala Leu Thr Val Ala Val Arg Lys Arg Ala Ala Ala Trp Gly Glu Ala           
                165                 170                 175               

ggc gtg cgc ctg aac acc atc gcc ccc ggt gca acc gag act ccc ttg        576
Gly Val Arg Leu Asn Thr Ile Ala Pro Gly Ala Thr Glu Thr Pro Leu           
            180                 185                 190                   

ctg cag gcg ggc ctg cag gac ccg cgc tat ggc gaa tcc att gcc aag        624
Leu Gln Ala Gly Leu Gln Asp Pro Arg Tyr Gly Glu Ser Ile Ala Lys           
        195                 200                 205                       

ttc gtt cct ccc atg ggc cgc cgt gcc gag ccg tcc gag atg gcg tcg        672
Phe Val Pro Pro Met Gly Arg Arg Ala Glu Pro Ser Glu Met Ala Ser           
    210                 215                 220                           

gtc atc gcc ttt ttg atg agc ccg gcc gca agc tat gtg cat ggc gcg        720
Val Ile Ala Phe Leu Met Ser Pro Ala Ala Ser Tyr Val His Gly Ala           
225                 230                 235                 240           

cag atc gtc att gat ggc ggc att gat gcg gtg atg cgc ccg aca cag        768
Gln Ile Val Ile Asp Gly Gly Ile Asp Ala Val Met Arg Pro Thr Gln           
                245                 250                 255               

ttc tga                                                                774
Phe                                                                       
                                                                          


<210>  6
<211>  257
<212>  PRT
<213>  Comamonas testosteroni

<400>  6

Met Ser Ile Ile Val Ile Ser Gly Cys Ala Thr Gly Ile Gly Ala Ala 
1               5                   10                  15      


Thr Arg Lys Val Leu Glu Ala Ala Gly His Gln Ile Val Gly Ile Asp 
            20                  25                  30          


Ile Arg Asp Ala Glu Val Ile Ala Asp Leu Ser Thr Ala Glu Gly Arg 
        35                  40                  45              


Lys Gln Ala Ile Ala Asp Val Leu Ala Lys Cys Ser Lys Gly Met Asp 
    50                  55                  60                  


Gly Leu Val Leu Cys Ala Gly Leu Gly Pro Gln Thr Lys Val Leu Gly 
65                  70                  75                  80  


Asn Val Val Ser Val Asn Tyr Phe Gly Ala Thr Glu Leu Met Asp Ala 
                85                  90                  95      


Phe Leu Pro Ala Leu Lys Lys Gly His Gln Pro Ala Ala Val Val Ile 
            100                 105                 110         


Ser Ser Val Ala Ser Ala His Leu Ala Phe Asp Lys Asn Pro Leu Ala 
        115                 120                 125             


Leu Ala Leu Glu Ala Gly Glu Glu Ala Lys Ala Arg Ala Ile Val Glu 
    130                 135                 140                 


His Ala Gly Glu Gln Gly Gly Asn Leu Ala Tyr Ala Gly Ser Lys Asn 
145                 150                 155                 160 


Ala Leu Thr Val Ala Val Arg Lys Arg Ala Ala Ala Trp Gly Glu Ala 
                165                 170                 175     


Gly Val Arg Leu Asn Thr Ile Ala Pro Gly Ala Thr Glu Thr Pro Leu 
            180                 185                 190         


Leu Gln Ala Gly Leu Gln Asp Pro Arg Tyr Gly Glu Ser Ile Ala Lys 
        195                 200                 205             


Phe Val Pro Pro Met Gly Arg Arg Ala Glu Pro Ser Glu Met Ala Ser 
    210                 215                 220                 


Val Ile Ala Phe Leu Met Ser Pro Ala Ala Ser Tyr Val His Gly Ala 
225                 230                 235                 240 


Gln Ile Val Ile Asp Gly Gly Ile Asp Ala Val Met Arg Pro Thr Gln 
                245                 250                 255     


Phe 
    


<210>  7
<211>  969
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  CDS
<222>  (1)..(969)

<400>  7
atg gat tcc ata tct ctg cgt gta gca cta aat gat ggt aac ttc att         48
Met Asp Ser Ile Ser Leu Arg Val Ala Leu Asn Asp Gly Asn Phe Ile           
1               5                   10                  15                

cct gta ctg ggg ttt gga acc act gtg cct gag aag gtt gct aag gat         96
Pro Val Leu Gly Phe Gly Thr Thr Val Pro Glu Lys Val Ala Lys Asp           
            20                  25                  30                    

gaa gtt atc aag gct act aaa ata gct ata gat aat gga ttc cgc cat        144
Glu Val Ile Lys Ala Thr Lys Ile Ala Ile Asp Asn Gly Phe Arg His           
        35                  40                  45                        

ttt gac tct gct tat ttg tac gaa gta gaa gag gaa gtg ggc caa gcc        192
Phe Asp Ser Ala Tyr Leu Tyr Glu Val Glu Glu Glu Val Gly Gln Ala           
    50                  55                  60                            

att aga agc aag att gaa gac ggc act gtg aag aga gaa gat ata ttc        240
Ile Arg Ser Lys Ile Glu Asp Gly Thr Val Lys Arg Glu Asp Ile Phe           
65                  70                  75                  80            

tat act tca aag ctt tgg agc act ttc cat aga cca gag ctg gtc cga        288
Tyr Thr Ser Lys Leu Trp Ser Thr Phe His Arg Pro Glu Leu Val Arg           
                85                  90                  95                

act tgc ttg gaa aag aca ctg aaa agc act caa ctg gac tat gtg gat        336
Thr Cys Leu Glu Lys Thr Leu Lys Ser Thr Gln Leu Asp Tyr Val Asp           
            100                 105                 110                   

ctt tat att att cat ttc cca atg gct ttg cag cct gga gat ata ttt        384
Leu Tyr Ile Ile His Phe Pro Met Ala Leu Gln Pro Gly Asp Ile Phe           
        115                 120                 125                       

ttc cca cga gat gag cat gga aaa cta ttg ttt gaa aca gtg gat atc        432
Phe Pro Arg Asp Glu His Gly Lys Leu Leu Phe Glu Thr Val Asp Ile           
    130                 135                 140                           

tgt gac aca tgg gag gcc atg gaa aag tgt aag gat gca gga ttg gcc        480
Cys Asp Thr Trp Glu Ala Met Glu Lys Cys Lys Asp Ala Gly Leu Ala           
145                 150                 155                 160           

aag tct att ggg gtg tcc aac ttt aac tgc agg cag ctg gag agg att        528
Lys Ser Ile Gly Val Ser Asn Phe Asn Cys Arg Gln Leu Glu Arg Ile           
                165                 170                 175               

ctg aat aag cca ggg ctc aaa tac aag cct gtg tgc aac cag gtg gaa        576
Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu           
            180                 185                 190                   

tgt cac ctt tat ctc aac cag agc aaa atg ctg gac tat tgt aag tca        624
Cys His Leu Tyr Leu Asn Gln Ser Lys Met Leu Asp Tyr Cys Lys Ser           
        195                 200                 205                       

aaa gac atc att ctg gtt tcc tac tgc acg ctg gga agt tca cga gac        672
Lys Asp Ile Ile Leu Val Ser Tyr Cys Thr Leu Gly Ser Ser Arg Asp           
    210                 215                 220                           

aaa aca tgg gtg gat cag aaa agt cca gtt ctc cta gat gat cca gtt        720
Lys Thr Trp Val Asp Gln Lys Ser Pro Val Leu Leu Asp Asp Pro Val           
225                 230                 235                 240           

ctt tgt gcc ata gca aag aag tac aag caa acc cca gcc cta gtt gcc        768
Leu Cys Ala Ile Ala Lys Lys Tyr Lys Gln Thr Pro Ala Leu Val Ala           
                245                 250                 255               

ctt cgc tac cag ctg cag cgt ggg gtt gtg ccc ctg atc agg agt ttc        816
Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Pro Leu Ile Arg Ser Phe           
            260                 265                 270                   

aac gcg aag cgg atc aaa gag cta aca cag gtt ttt gaa ttc cag ttg        864
Asn Ala Lys Arg Ile Lys Glu Leu Thr Gln Val Phe Glu Phe Gln Leu           
        275                 280                 285                       

gct tca gag gac atg aaa gcc ctg gat ggc ttg aac aga aat ttc aga        912
Ala Ser Glu Asp Met Lys Ala Leu Asp Gly Leu Asn Arg Asn Phe Arg           
    290                 295                 300                           

tac aac aat gca aaa tat ttt gat gac cat ccc aat cat cca ttt act        960
Tyr Asn Asn Ala Lys Tyr Phe Asp Asp His Pro Asn His Pro Phe Thr           
305                 310                 315                 320           

gat gaa tag                                                            969
Asp Glu                                                                   
                                                                          


<210>  8
<211>  322
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Met Asp Ser Ile Ser Leu Arg Val Ala Leu Asn Asp Gly Asn Phe Ile 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Thr Thr Val Pro Glu Lys Val Ala Lys Asp 
            20                  25                  30          


Glu Val Ile Lys Ala Thr Lys Ile Ala Ile Asp Asn Gly Phe Arg His 
        35                  40                  45              


Phe Asp Ser Ala Tyr Leu Tyr Glu Val Glu Glu Glu Val Gly Gln Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Glu Asp Gly Thr Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Thr Ser Lys Leu Trp Ser Thr Phe His Arg Pro Glu Leu Val Arg 
                85                  90                  95      


Thr Cys Leu Glu Lys Thr Leu Lys Ser Thr Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Ile Ile His Phe Pro Met Ala Leu Gln Pro Gly Asp Ile Phe 
        115                 120                 125             


Phe Pro Arg Asp Glu His Gly Lys Leu Leu Phe Glu Thr Val Asp Ile 
    130                 135                 140                 


Cys Asp Thr Trp Glu Ala Met Glu Lys Cys Lys Asp Ala Gly Leu Ala 
145                 150                 155                 160 


Lys Ser Ile Gly Val Ser Asn Phe Asn Cys Arg Gln Leu Glu Arg Ile 
                165                 170                 175     


Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
            180                 185                 190         


Cys His Leu Tyr Leu Asn Gln Ser Lys Met Leu Asp Tyr Cys Lys Ser 
        195                 200                 205             


Lys Asp Ile Ile Leu Val Ser Tyr Cys Thr Leu Gly Ser Ser Arg Asp 
    210                 215                 220                 


Lys Thr Trp Val Asp Gln Lys Ser Pro Val Leu Leu Asp Asp Pro Val 
225                 230                 235                 240 


Leu Cys Ala Ile Ala Lys Lys Tyr Lys Gln Thr Pro Ala Leu Val Ala 
                245                 250                 255     


Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Pro Leu Ile Arg Ser Phe 
            260                 265                 270         


Asn Ala Lys Arg Ile Lys Glu Leu Thr Gln Val Phe Glu Phe Gln Leu 
        275                 280                 285             


Ala Ser Glu Asp Met Lys Ala Leu Asp Gly Leu Asn Arg Asn Phe Arg 
    290                 295                 300                 


Tyr Asn Asn Ala Lys Tyr Phe Asp Asp His Pro Asn His Pro Phe Thr 
305                 310                 315                 320 


Asp Glu 
        


<210>  9
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  9
cgtcgtcatg gtcgcccgtc gcgagg                                            26


<210>  10
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  10
cctcgcgacg ggcgaccatg acgacg                                            26


<210>  11
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  11
cgtcgtcatg gtcagccgtc gcgagg                                            26


<210>  12
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  12
cctcgcgacg gctgaccatg acgacg                                            26


<210>  13
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  13
gcgaattcgt gaaaggagat atacatgaac ctgagggaga agtacgg                     47


<210>  14
<211>  1206
<212>  DNA
<213>  Artificial

<220>
<223>  Formiate Deydrogenase Mutant


<220>
<221>  CDS
<222>  (1)..(1206)

<400>  14
atg gca aag gtc ctg tgc gtt ctt tac gat gat ccg gtc gac ggc tac         48
Met Ala Lys Val Leu Cys Val Leu Tyr Asp Asp Pro Val Asp Gly Tyr           
1               5                   10                  15                

ccg aag acc tat gcc cgc gac gat ctt ccg aag atc gac cac tat ccg         96
Pro Lys Thr Tyr Ala Arg Asp Asp Leu Pro Lys Ile Asp His Tyr Pro           
            20                  25                  30                    

ggc ggc cag atc ttg ccg acg ccg aag gcc atc gac ttc acg ccc ggg        144
Gly Gly Gln Ile Leu Pro Thr Pro Lys Ala Ile Asp Phe Thr Pro Gly           
        35                  40                  45                        

cag ttg ctc ggc tcc gtc tcc ggc gag ctc ggc ctg cgc gaa tat ctc        192
Gln Leu Leu Gly Ser Val Ser Gly Glu Leu Gly Leu Arg Glu Tyr Leu           
    50                  55                  60                            

gaa tcc aac ggc cac acc ctg gtc gtg acc tcc gac aag gac ggc ccc        240
Glu Ser Asn Gly His Thr Leu Val Val Thr Ser Asp Lys Asp Gly Pro           
65                  70                  75                  80            

gac tcg gtg ttc gag cgc gag ctg gtc gat gcg gat gtc gtc atc tcc        288
Asp Ser Val Phe Glu Arg Glu Leu Val Asp Ala Asp Val Val Ile Ser           
                85                  90                  95                

cag ccc ttc tgg ccg gcc tat ctg acg ccc gag cgc atc gcc aag gcc        336
Gln Pro Phe Trp Pro Ala Tyr Leu Thr Pro Glu Arg Ile Ala Lys Ala           
            100                 105                 110                   

aag aac ctg aag ctc gcg ctc acc gcc ggc atc ggt tcc gac cac gtc        384
Lys Asn Leu Lys Leu Ala Leu Thr Ala Gly Ile Gly Ser Asp His Val           
        115                 120                 125                       

gat ctt cag tcg gct atc gac cgc aac gtc acc gtg gcg gaa gtc acc        432
Asp Leu Gln Ser Ala Ile Asp Arg Asn Val Thr Val Ala Glu Val Thr           
    130                 135                 140                           

tac tgc aac tcg atc agc gtc gcc gag cat gtg gtg atg atg atc ctg        480
Tyr Cys Asn Ser Ile Ser Val Ala Glu His Val Val Met Met Ile Leu           
145                 150                 155                 160           

tcg ctg gtg cgc aac tat ctg ccc tcg cac gaa tgg gcg cgg aag ggc        528
Ser Leu Val Arg Asn Tyr Leu Pro Ser His Glu Trp Ala Arg Lys Gly           
                165                 170                 175               

ggc tgg aac atc gcc gac tgc gtc tcc cac gcc tac gac ctc gag gcg        576
Gly Trp Asn Ile Ala Asp Cys Val Ser His Ala Tyr Asp Leu Glu Ala           
            180                 185                 190                   

atg cat gtc ggc acc gtg gcc gcc ggc cgc atc ggt ctc gcg gtg ctg        624
Met His Val Gly Thr Val Ala Ala Gly Arg Ile Gly Leu Ala Val Leu           
        195                 200                 205                       

cgc cgt ctg gcg ccg ttc gac gtg cac ctg cac tac acc ggc cgt cac        672
Arg Arg Leu Ala Pro Phe Asp Val His Leu His Tyr Thr Gly Arg His           
    210                 215                 220                           

cgc ctg ccg gaa tcg gtc gag aag gag ctc aac ctc acc tgg cac gcg        720
Arg Leu Pro Glu Ser Val Glu Lys Glu Leu Asn Leu Thr Trp His Ala           
225                 230                 235                 240           

acc cgc gag gac atg tat ccg gtt tgc gac gtg gtg acg ctg aac tgc        768
Thr Arg Glu Asp Met Tyr Pro Val Cys Asp Val Val Thr Leu Asn Cys           
                245                 250                 255               

ccg ctg cac ccc gaa acc gag cac atg atc aat gac gag acg ctg aag        816
Pro Leu His Pro Glu Thr Glu His Met Ile Asn Asp Glu Thr Leu Lys           
            260                 265                 270                   

ctg ttc aag cgt ggc gcc tac atc gtc aac acc gcc cgc ggc aag ctg        864
Leu Phe Lys Arg Gly Ala Tyr Ile Val Asn Thr Ala Arg Gly Lys Leu           
        275                 280                 285                       

tgc gac cgc gat gcc gtg gca cgt gcg ctc gaa tcc ggc cgg ctg gcc        912
Cys Asp Arg Asp Ala Val Ala Arg Ala Leu Glu Ser Gly Arg Leu Ala           
    290                 295                 300                           

ggc tat gcc ggc gac gtg tgg ttc ccg cag ccg gcg ccg aag gac cac        960
Gly Tyr Ala Gly Asp Val Trp Phe Pro Gln Pro Ala Pro Lys Asp His           
305                 310                 315                 320           

ccc tgg cgg acg atg ccc tat aac ggc atg acc ccg cac atc tcc ggc       1008
Pro Trp Arg Thr Met Pro Tyr Asn Gly Met Thr Pro His Ile Ser Gly           
                325                 330                 335               

acc acg ctg acc gcg cag gcg cgt tat gcg gcg ggc acc cgc gag atc       1056
Thr Thr Leu Thr Ala Gln Ala Arg Tyr Ala Ala Gly Thr Arg Glu Ile           
            340                 345                 350                   

ctg gag tgc ttc ttc gag ggc cgt ccg atc cgc gac gaa tac ctc atc       1104
Leu Glu Cys Phe Phe Glu Gly Arg Pro Ile Arg Asp Glu Tyr Leu Ile           
        355                 360                 365                       

gtg cag ggc ggc gct ctt gcc ggc acc ggc gcg cat tcc tac tcg aag       1152
Val Gln Gly Gly Ala Leu Ala Gly Thr Gly Ala His Ser Tyr Ser Lys           
    370                 375                 380                           

ggc aat gcc acc ggc ggt tcg gaa gag gcc gcc aag ttc aag aag gcg       1200
Gly Asn Ala Thr Gly Gly Ser Glu Glu Ala Ala Lys Phe Lys Lys Ala           
385                 390                 395                 400           

gtc tga                                                               1206
Val                                                                       
                                                                          


<210>  15
<211>  401
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  15

Met Ala Lys Val Leu Cys Val Leu Tyr Asp Asp Pro Val Asp Gly Tyr 
1               5                   10                  15      


Pro Lys Thr Tyr Ala Arg Asp Asp Leu Pro Lys Ile Asp His Tyr Pro 
            20                  25                  30          


Gly Gly Gln Ile Leu Pro Thr Pro Lys Ala Ile Asp Phe Thr Pro Gly 
        35                  40                  45              


Gln Leu Leu Gly Ser Val Ser Gly Glu Leu Gly Leu Arg Glu Tyr Leu 
    50                  55                  60                  


Glu Ser Asn Gly His Thr Leu Val Val Thr Ser Asp Lys Asp Gly Pro 
65                  70                  75                  80  


Asp Ser Val Phe Glu Arg Glu Leu Val Asp Ala Asp Val Val Ile Ser 
                85                  90                  95      


Gln Pro Phe Trp Pro Ala Tyr Leu Thr Pro Glu Arg Ile Ala Lys Ala 
            100                 105                 110         


Lys Asn Leu Lys Leu Ala Leu Thr Ala Gly Ile Gly Ser Asp His Val 
        115                 120                 125             


Asp Leu Gln Ser Ala Ile Asp Arg Asn Val Thr Val Ala Glu Val Thr 
    130                 135                 140                 


Tyr Cys Asn Ser Ile Ser Val Ala Glu His Val Val Met Met Ile Leu 
145                 150                 155                 160 


Ser Leu Val Arg Asn Tyr Leu Pro Ser His Glu Trp Ala Arg Lys Gly 
                165                 170                 175     


Gly Trp Asn Ile Ala Asp Cys Val Ser His Ala Tyr Asp Leu Glu Ala 
            180                 185                 190         


Met His Val Gly Thr Val Ala Ala Gly Arg Ile Gly Leu Ala Val Leu 
        195                 200                 205             


Arg Arg Leu Ala Pro Phe Asp Val His Leu His Tyr Thr Gly Arg His 
    210                 215                 220                 


Arg Leu Pro Glu Ser Val Glu Lys Glu Leu Asn Leu Thr Trp His Ala 
225                 230                 235                 240 


Thr Arg Glu Asp Met Tyr Pro Val Cys Asp Val Val Thr Leu Asn Cys 
                245                 250                 255     


Pro Leu His Pro Glu Thr Glu His Met Ile Asn Asp Glu Thr Leu Lys 
            260                 265                 270         


Leu Phe Lys Arg Gly Ala Tyr Ile Val Asn Thr Ala Arg Gly Lys Leu 
        275                 280                 285             


Cys Asp Arg Asp Ala Val Ala Arg Ala Leu Glu Ser Gly Arg Leu Ala 
    290                 295                 300                 


Gly Tyr Ala Gly Asp Val Trp Phe Pro Gln Pro Ala Pro Lys Asp His 
305                 310                 315                 320 


Pro Trp Arg Thr Met Pro Tyr Asn Gly Met Thr Pro His Ile Ser Gly 
                325                 330                 335     


Thr Thr Leu Thr Ala Gln Ala Arg Tyr Ala Ala Gly Thr Arg Glu Ile 
            340                 345                 350         


Leu Glu Cys Phe Phe Glu Gly Arg Pro Ile Arg Asp Glu Tyr Leu Ile 
        355                 360                 365             


Val Gln Gly Gly Ala Leu Ala Gly Thr Gly Ala His Ser Tyr Ser Lys 
    370                 375                 380                 


Gly Asn Ala Thr Gly Gly Ser Glu Glu Ala Ala Lys Phe Lys Lys Ala 
385                 390                 395                 400 


Val 
    


<210>  16
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  16
cccaagctta aggagatata catgtccatc atcgtgataa gcg                         43


<210>  17
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  17
ataagaatgc ggccgctcag aactgtgtcg ggcg                                   34


<210>  18
<211>  7404
<212>  DNA
<213>  Artificial

<220>
<223>  Plasmid pET21a FDH D221G 7beta-HSDH


<220>
<221>  CDS
<222>  (5208)..(6422)
<223>  FDH D221G

<220>
<221>  CDS
<222>  (6435)..(7226)
<223>  7beta-HSDH

<400>  18
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat      600

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt      660

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg      720

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga      780

agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg      840

tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt      900

tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg      960

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg     1020

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     1080

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     1140

tgcagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc     1200

ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     1260

ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg     1320

cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac     1380

gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     1440

actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt     1500

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac     1560

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa     1620

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc     1680

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt     1740

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg     1800

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc     1860

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt     1920

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga     1980

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct     2040

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg     2100

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     2160

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa     2220

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt     2280

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga     2340

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga     2400

gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatatgg     2460

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat     2520

cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct     2580

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     2640

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagctg cggtaaagct     2700

catcagcgtg gtcgtgaagc gattcacaga tgtctgcctg ttcatccgcg tccagctcgt     2760

tgagtttctc cagaagcgtt aatgtctggc ttctgataaa gcgggccatg ttaagggcgg     2820

ttttttcctg tttggtcact gatgcctccg tgtaaggggg atttctgttc atgggggtaa     2880

tgataccgat gaaacgagag aggatgctca cgatacgggt tactgatgat gaacatgccc     2940

ggttactgga acgttgtgag ggtaaacaac tggcggtatg gatgcggcgg gaccagagaa     3000

aaatcactca gggtcaatgc cagcgcttcg ttaatacaga tgtaggtgtt ccacagggta     3060

gccagcagca tcctgcgatg cagatccgga acataatggt gcagggcgct gacttccgcg     3120

tttccagact ttacgaaaca cggaaaccga agaccattca tgttgttgct caggtcgcag     3180

acgttttgca gcagcagtcg cttcacgttc gctcgcgtat cggtgattca ttctgctaac     3240

cagtaaggca accccgccag cctagccggg tcctcaacga caggagcacg atcatgcgca     3300

cccgtggggc cgccatgccg gcgataatgg cctgcttctc gccgaaacgt ttggtggcgg     3360

gaccagtgac gaaggcttga gcgagggcgt gcaagattcc gaataccgca agcgacaggc     3420

cgatcatcgt cgcgctccag cgaaagcggt cctcgccgaa aatgacccag agcgctgccg     3480

gcacctgtcc tacgagttgc atgataaaga agacagtcat aagtgcggcg acgatagtca     3540

tgccccgcgc ccaccggaag gagctgactg ggttgaaggc tctcaagggc atcggtcgag     3600

atcccggtgc ctaatgagtg agctaactta cattaattgc gttgcgctca ctgcccgctt     3660

tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag     3720

gcggtttgcg tattgggcgc cagggtggtt tttcttttca ccagtgagac gggcaacagc     3780

tgattgccct tcaccgcctg gccctgagag agttgcagca agcggtccac gctggtttgc     3840

cccagcaggc gaaaatcctg tttgatggtg gttaacggcg ggatataaca tgagctgtct     3900

tcggtatcgt cgtatcccac taccgagata tccgcaccaa cgcgcagccc ggactcggta     3960

atggcgcgca ttgcgcccag cgccatctga tcgttggcaa ccagcatcgc agtgggaacg     4020

atgccctcat tcagcatttg catggtttgt tgaaaaccgg acatggcact ccagtcgcct     4080

tcccgttccg ctatcggctg aatttgattg cgagtgagat atttatgcca gccagccaga     4140

cgcagacgcg ccgagacaga acttaatggg cccgctaaca gcgcgatttg ctggtgaccc     4200

aatgcgacca gatgctccac gcccagtcgc gtaccgtctt catgggagaa aataatactg     4260

ttgatgggtg tctggtcaga gacatcaaga aataacgccg gaacattagt gcaggcagct     4320

tccacagcaa tggcatcctg gtcatccagc ggatagttaa tgatcagccc actgacgcgt     4380

tgcgcgagaa gattgtgcac cgccgcttta caggcttcga cgccgcttcg ttctaccatc     4440

gacaccacca cgctggcacc cagttgatcg gcgcgagatt taatcgccgc gacaatttgc     4500

gacggcgcgt gcagggccag actggaggtg gcaacgccaa tcagcaacga ctgtttgccc     4560

gccagttgtt gtgccacgcg gttgggaatg taattcagct ccgccatcgc cgcttccact     4620

ttttcccgcg ttttcgcaga aacgtggctg gcctggttca ccacgcggga aacggtctga     4680

taagagacac cggcatactc tgcgacatcg tataacgtta ctggtttcac attcaccacc     4740

ctgaattgac tctcttccgg gcgctatcat gccataccgc gaaaggtttt gcgccattcg     4800

atggtgtccg ggatctcgac gctctccctt atgcgactcc tgcattagga agcagcccag     4860

tagtaggttg aggccgttga gcaccgccgc cgcaaggaat ggtgcatgca aggagatggc     4920

gcccaacagt cccccggcca cggggcctgc caccataccc acgccgaaac aagcgctcat     4980

gagcccgaag tggcgagccc gatcttcccc atcggtgatg tcggcgatat aggcgccagc     5040

aaccgcacct gtggcgccgg tgatgccggc cacgatgcgt ccggcgtaga ggatcgagat     5100

ctcgatcccg cgaaattaat acgactcact ataggggaat tgtgagcgga taacaattcc     5160

cctctagaaa taattttgtt taactttaag aaggagatat acatatg atg gca aag       5216
                                                    Met Ala Lys           
                                                    1                     

gtc ctg tgc gtt ctt tac gat gat ccg gtc gac ggc tac ccg aag acc       5264
Val Leu Cys Val Leu Tyr Asp Asp Pro Val Asp Gly Tyr Pro Lys Thr           
    5                   10                  15                            

tat gcc cgc gac gat ctt ccg aag atc gac cac tat ccg ggc ggc cag       5312
Tyr Ala Arg Asp Asp Leu Pro Lys Ile Asp His Tyr Pro Gly Gly Gln           
20                  25                  30                  35            

atc ttg ccg acg ccg aag gcc atc gac ttc acg ccc ggg cag ttg ctc       5360
Ile Leu Pro Thr Pro Lys Ala Ile Asp Phe Thr Pro Gly Gln Leu Leu           
                40                  45                  50                

ggc tcc gtc tcc ggc gag ctc ggc ctg cgc gaa tat ctc gaa tcc aac       5408
Gly Ser Val Ser Gly Glu Leu Gly Leu Arg Glu Tyr Leu Glu Ser Asn           
            55                  60                  65                    

ggc cac acc ctg gtc gtg acc tcc gac aag gac ggc ccc gac tcg gtg       5456
Gly His Thr Leu Val Val Thr Ser Asp Lys Asp Gly Pro Asp Ser Val           
        70                  75                  80                        

ttc gag cgc gag ctg gtc gat gcg gat gtc gtc atc tcc cag ccc ttc       5504
Phe Glu Arg Glu Leu Val Asp Ala Asp Val Val Ile Ser Gln Pro Phe           
    85                  90                  95                            

tgg ccg gcc tat ctg acg ccc gag cgc atc gcc aag gcc aag aac ctg       5552
Trp Pro Ala Tyr Leu Thr Pro Glu Arg Ile Ala Lys Ala Lys Asn Leu           
100                 105                 110                 115           

aag ctc gcg ctc acc gcc ggc atc ggt tcc gac cac gtc gat ctt cag       5600
Lys Leu Ala Leu Thr Ala Gly Ile Gly Ser Asp His Val Asp Leu Gln           
                120                 125                 130               

tcg gct atc gac cgc aac gtc acc gtg gcg gaa gtc acc tac tgc aac       5648
Ser Ala Ile Asp Arg Asn Val Thr Val Ala Glu Val Thr Tyr Cys Asn           
            135                 140                 145                   

tcg atc agc gtc gcc gag cat gtg gtg atg atg atc ctg tcg ctg gtg       5696
Ser Ile Ser Val Ala Glu His Val Val Met Met Ile Leu Ser Leu Val           
        150                 155                 160                       

cgc aac tat ctg ccc tcg cac gaa tgg gcg cgg aag ggc ggc tgg aac       5744
Arg Asn Tyr Leu Pro Ser His Glu Trp Ala Arg Lys Gly Gly Trp Asn           
    165                 170                 175                           

atc gcc gac tgc gtc tcc cac gcc tac gac ctc gag gcg atg cat gtc       5792
Ile Ala Asp Cys Val Ser His Ala Tyr Asp Leu Glu Ala Met His Val           
180                 185                 190                 195           

ggc acc gtg gcc gcc ggc cgc atc ggt ctc gcg gtg ctg cgc cgt ctg       5840
Gly Thr Val Ala Ala Gly Arg Ile Gly Leu Ala Val Leu Arg Arg Leu           
                200                 205                 210               

gcg ccg ttc gac gtg cac ctg cac tac acc ggc cgt cac cgc ctg ccg       5888
Ala Pro Phe Asp Val His Leu His Tyr Thr Gly Arg His Arg Leu Pro           
            215                 220                 225                   

gaa tcg gtc gag aag gag ctc aac ctc acc tgg cac gcg acc cgc gag       5936
Glu Ser Val Glu Lys Glu Leu Asn Leu Thr Trp His Ala Thr Arg Glu           
        230                 235                 240                       

gac atg tat ccg gtt tgc gac gtg gtg acg ctg aac tgc ccg ctg cac       5984
Asp Met Tyr Pro Val Cys Asp Val Val Thr Leu Asn Cys Pro Leu His           
    245                 250                 255                           

ccc gaa acc gag cac atg atc aat gac gag acg ctg aag ctg ttc aag       6032
Pro Glu Thr Glu His Met Ile Asn Asp Glu Thr Leu Lys Leu Phe Lys           
260                 265                 270                 275           

cgt ggc gcc tac atc gtc aac acc gcc cgc ggc aag ctg tgc gac cgc       6080
Arg Gly Ala Tyr Ile Val Asn Thr Ala Arg Gly Lys Leu Cys Asp Arg           
                280                 285                 290               

gat gcc gtg gca cgt gcg ctc gaa tcc ggc cgg ctg gcc ggc tat gcc       6128
Asp Ala Val Ala Arg Ala Leu Glu Ser Gly Arg Leu Ala Gly Tyr Ala           
            295                 300                 305                   

ggc gac gtg tgg ttc ccg cag ccg gcg ccg aag gac cac ccc tgg cgg       6176
Gly Asp Val Trp Phe Pro Gln Pro Ala Pro Lys Asp His Pro Trp Arg           
        310                 315                 320                       

acg atg ccc tat aac ggc atg acc ccg cac atc tcc ggc acc acg ctg       6224
Thr Met Pro Tyr Asn Gly Met Thr Pro His Ile Ser Gly Thr Thr Leu           
    325                 330                 335                           

acc gcg cag gcg cgt tat gcg gcg ggc acc cgc gag atc ctg gag tgc       6272
Thr Ala Gln Ala Arg Tyr Ala Ala Gly Thr Arg Glu Ile Leu Glu Cys           
340                 345                 350                 355           

ttc ttc gag ggc cgt ccg atc cgc gac gaa tac ctc atc gtg cag ggc       6320
Phe Phe Glu Gly Arg Pro Ile Arg Asp Glu Tyr Leu Ile Val Gln Gly           
                360                 365                 370               

ggc gct ctt gcc ggc acc ggc gcg cat tcc tac tcg aag ggc aat gcc       6368
Gly Ala Leu Ala Gly Thr Gly Ala His Ser Tyr Ser Lys Gly Asn Ala           
            375                 380                 385                   

acc ggc ggt tcg gaa gag gcc gcc aag ttc aag aag gcg gct gag aat       6416
Thr Gly Gly Ser Glu Glu Ala Ala Lys Phe Lys Lys Ala Ala Glu Asn           
        390                 395                 400                       

tcg tga aaggagatat ac atg aac ctg agg gag aag tac ggt gag tgg ggc     6467
Ser                   Met Asn Leu Arg Glu Lys Tyr Gly Glu Trp Gly         
                      405                 410                 415         

ctg atc ctg ggc gcg acc gag ggc gtc ggc aag gcg ttc tgc gag aag       6515
Leu Ile Leu Gly Ala Thr Glu Gly Val Gly Lys Ala Phe Cys Glu Lys           
                420                 425                 430               

atc gcc gcc ggc ggc atg aac gtc gtc atg gtc ggc cgt cgc gag gag       6563
Ile Ala Ala Gly Gly Met Asn Val Val Met Val Gly Arg Arg Glu Glu           
            435                 440                 445                   

aag ctg aac gtg ctc gca ggc gag atc cgc gag acc tac ggc gtg gag       6611
Lys Leu Asn Val Leu Ala Gly Glu Ile Arg Glu Thr Tyr Gly Val Glu           
        450                 455                 460                       

acc aag gtc gtg cgc gcc gac ttt agc cag ccc ggc gct gcc gag acc       6659
Thr Lys Val Val Arg Ala Asp Phe Ser Gln Pro Gly Ala Ala Glu Thr           
    465                 470                 475                           

gtc ttc gcc gcg acc gag ggc ctg gac atg ggc ttc atg agc tac gtg       6707
Val Phe Ala Ala Thr Glu Gly Leu Asp Met Gly Phe Met Ser Tyr Val           
480                 485                 490                 495           

gcc tgc ctg cac agc ttc ggt aag atc cag gac acc ccc tgg gag aag       6755
Ala Cys Leu His Ser Phe Gly Lys Ile Gln Asp Thr Pro Trp Glu Lys           
                500                 505                 510               

cac gag gcc atg atc aac gtc aac gtc gtg acc ttc ctc aag tgc ttc       6803
His Glu Ala Met Ile Asn Val Asn Val Val Thr Phe Leu Lys Cys Phe           
            515                 520                 525                   

cac cac tac atg cgg atc ttt gcc gcc cag gac cgc ggc gcc gtg atc       6851
His His Tyr Met Arg Ile Phe Ala Ala Gln Asp Arg Gly Ala Val Ile           
        530                 535                 540                       

aac gtc tcg tcg atg acc ggc atc agc tcc agc ccc tgg aac ggc cag       6899
Asn Val Ser Ser Met Thr Gly Ile Ser Ser Ser Pro Trp Asn Gly Gln           
    545                 550                 555                           

tac ggc gcg ggc aag gcc ttc atc ctc aag atg acc gag gcc gtg gcc       6947
Tyr Gly Ala Gly Lys Ala Phe Ile Leu Lys Met Thr Glu Ala Val Ala           
560                 565                 570                 575           

tgc gag tgc gag ggc acc ggc gtc gac gtc gag gtc atc acc ctc ggc       6995
Cys Glu Cys Glu Gly Thr Gly Val Asp Val Glu Val Ile Thr Leu Gly           
                580                 585                 590               

acc acc cta acc ccc agc ctg ctg tcc aac ctc ccc ggc ggc ccg cag       7043
Thr Thr Leu Thr Pro Ser Leu Leu Ser Asn Leu Pro Gly Gly Pro Gln           
            595                 600                 605                   

ggc gag gcc gtc atg aag atc gcc ctc acc ccc gag gag tgc gtt gac       7091
Gly Glu Ala Val Met Lys Ile Ala Leu Thr Pro Glu Glu Cys Val Asp           
        610                 615                 620                       

gag gcc ttt gag aag ctg ggt aag gag ctc tcc gtc atc gcc ggc cag       7139
Glu Ala Phe Glu Lys Leu Gly Lys Glu Leu Ser Val Ile Ala Gly Gln           
    625                 630                 635                           

cgc aac aag gac tcc gtc cac gac tgg aag gca aac cac acc gag gac       7187
Arg Asn Lys Asp Ser Val His Asp Trp Lys Ala Asn His Thr Glu Asp           
640                 645                 650                 655           

gag tac atc cgc tac atg ggg tcg ttc tac cgc gac tag aagcttgcgg        7236
Glu Tyr Ile Arg Tyr Met Gly Ser Phe Tyr Arg Asp                           
                660                 665                                   

ccgcactcga gcaccaccac caccaccact gagatccggc tgctaacaaa gcccgaaagg     7296

aagctgagtt ggctgctgcc accgctgagc aataactagc ataacccctt ggggcctcta     7356

aacgggtctt gaggggtttt ttgctgaaag gaggaactat atccggat                  7404


<210>  19
<211>  404
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  19

Met Ala Lys Val Leu Cys Val Leu Tyr Asp Asp Pro Val Asp Gly Tyr 
1               5                   10                  15      


Pro Lys Thr Tyr Ala Arg Asp Asp Leu Pro Lys Ile Asp His Tyr Pro 
            20                  25                  30          


Gly Gly Gln Ile Leu Pro Thr Pro Lys Ala Ile Asp Phe Thr Pro Gly 
        35                  40                  45              


Gln Leu Leu Gly Ser Val Ser Gly Glu Leu Gly Leu Arg Glu Tyr Leu 
    50                  55                  60                  


Glu Ser Asn Gly His Thr Leu Val Val Thr Ser Asp Lys Asp Gly Pro 
65                  70                  75                  80  


Asp Ser Val Phe Glu Arg Glu Leu Val Asp Ala Asp Val Val Ile Ser 
                85                  90                  95      


Gln Pro Phe Trp Pro Ala Tyr Leu Thr Pro Glu Arg Ile Ala Lys Ala 
            100                 105                 110         


Lys Asn Leu Lys Leu Ala Leu Thr Ala Gly Ile Gly Ser Asp His Val 
        115                 120                 125             


Asp Leu Gln Ser Ala Ile Asp Arg Asn Val Thr Val Ala Glu Val Thr 
    130                 135                 140                 


Tyr Cys Asn Ser Ile Ser Val Ala Glu His Val Val Met Met Ile Leu 
145                 150                 155                 160 


Ser Leu Val Arg Asn Tyr Leu Pro Ser His Glu Trp Ala Arg Lys Gly 
                165                 170                 175     


Gly Trp Asn Ile Ala Asp Cys Val Ser His Ala Tyr Asp Leu Glu Ala 
            180                 185                 190         


Met His Val Gly Thr Val Ala Ala Gly Arg Ile Gly Leu Ala Val Leu 
        195                 200                 205             


Arg Arg Leu Ala Pro Phe Asp Val His Leu His Tyr Thr Gly Arg His 
    210                 215                 220                 


Arg Leu Pro Glu Ser Val Glu Lys Glu Leu Asn Leu Thr Trp His Ala 
225                 230                 235                 240 


Thr Arg Glu Asp Met Tyr Pro Val Cys Asp Val Val Thr Leu Asn Cys 
                245                 250                 255     


Pro Leu His Pro Glu Thr Glu His Met Ile Asn Asp Glu Thr Leu Lys 
            260                 265                 270         


Leu Phe Lys Arg Gly Ala Tyr Ile Val Asn Thr Ala Arg Gly Lys Leu 
        275                 280                 285             


Cys Asp Arg Asp Ala Val Ala Arg Ala Leu Glu Ser Gly Arg Leu Ala 
    290                 295                 300                 


Gly Tyr Ala Gly Asp Val Trp Phe Pro Gln Pro Ala Pro Lys Asp His 
305                 310                 315                 320 


Pro Trp Arg Thr Met Pro Tyr Asn Gly Met Thr Pro His Ile Ser Gly 
                325                 330                 335     


Thr Thr Leu Thr Ala Gln Ala Arg Tyr Ala Ala Gly Thr Arg Glu Ile 
            340                 345                 350         


Leu Glu Cys Phe Phe Glu Gly Arg Pro Ile Arg Asp Glu Tyr Leu Ile 
        355                 360                 365             


Val Gln Gly Gly Ala Leu Ala Gly Thr Gly Ala His Ser Tyr Ser Lys 
    370                 375                 380                 


Gly Asn Ala Thr Gly Gly Ser Glu Glu Ala Ala Lys Phe Lys Lys Ala 
385                 390                 395                 400 


Ala Glu Asn Ser 
                


<210>  20
<211>  263
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  20

Met Asn Leu Arg Glu Lys Tyr Gly Glu Trp Gly Leu Ile Leu Gly Ala 
1               5                   10                  15      


Thr Glu Gly Val Gly Lys Ala Phe Cys Glu Lys Ile Ala Ala Gly Gly 
            20                  25                  30          


Met Asn Val Val Met Val Gly Arg Arg Glu Glu Lys Leu Asn Val Leu 
        35                  40                  45              


Ala Gly Glu Ile Arg Glu Thr Tyr Gly Val Glu Thr Lys Val Val Arg 
    50                  55                  60                  


Ala Asp Phe Ser Gln Pro Gly Ala Ala Glu Thr Val Phe Ala Ala Thr 
65                  70                  75                  80  


Glu Gly Leu Asp Met Gly Phe Met Ser Tyr Val Ala Cys Leu His Ser 
                85                  90                  95      


Phe Gly Lys Ile Gln Asp Thr Pro Trp Glu Lys His Glu Ala Met Ile 
            100                 105                 110         


Asn Val Asn Val Val Thr Phe Leu Lys Cys Phe His His Tyr Met Arg 
        115                 120                 125             


Ile Phe Ala Ala Gln Asp Arg Gly Ala Val Ile Asn Val Ser Ser Met 
    130                 135                 140                 


Thr Gly Ile Ser Ser Ser Pro Trp Asn Gly Gln Tyr Gly Ala Gly Lys 
145                 150                 155                 160 


Ala Phe Ile Leu Lys Met Thr Glu Ala Val Ala Cys Glu Cys Glu Gly 
                165                 170                 175     


Thr Gly Val Asp Val Glu Val Ile Thr Leu Gly Thr Thr Leu Thr Pro 
            180                 185                 190         


Ser Leu Leu Ser Asn Leu Pro Gly Gly Pro Gln Gly Glu Ala Val Met 
        195                 200                 205             


Lys Ile Ala Leu Thr Pro Glu Glu Cys Val Asp Glu Ala Phe Glu Lys 
    210                 215                 220                 


Leu Gly Lys Glu Leu Ser Val Ile Ala Gly Gln Arg Asn Lys Asp Ser 
225                 230                 235                 240 


Val His Asp Trp Lys Ala Asn His Thr Glu Asp Glu Tyr Ile Arg Tyr 
                245                 250                 255     


Met Gly Ser Phe Tyr Arg Asp 
            260             


<210>  21
<211>  4302
<212>  DNA
<213>  Artificial

<220>
<223>  Plasmid pCOLA(mod) 3alpha-HSDH


<220>
<221>  CDS
<222>  (303)..(1076)
<223>  3alpha-HSDH

<400>  21
ggggaattgt gagcggataa caattcccct gtagaaataa ttttgtttaa ctttaataag       60

gagatatacc atgggcagca gccatcacca tcatcaccac agccaggatc cgaattcgag      120

ctcggcgcgc ctgcaggtcg acaagcttgc ggccgcataa tgcttaagtc gaacagaaag      180

taatcgtatt gtacacggcc gcataatcga aattaatacg actcactata ggggaattgt      240

gagcggataa caattcccca tcttagtata ttagttaagt ataagaagga gatatacata      300

tg atg tcc atc atc gtg ata agc ggc tgc gcc acc ggc att ggt gcc         347
   Met Ser Ile Ile Val Ile Ser Gly Cys Ala Thr Gly Ile Gly Ala            
   1               5                   10                  15             

gct acg cgc aag gtc ctg gag gcg gcc ggt cac cag atc gta ggc atc        395
Ala Thr Arg Lys Val Leu Glu Ala Ala Gly His Gln Ile Val Gly Ile           
                20                  25                  30                

gat ata cgc gat gcg gaa gtg att gcc gat ctc tcg acg gcc gaa ggt        443
Asp Ile Arg Asp Ala Glu Val Ile Ala Asp Leu Ser Thr Ala Glu Gly           
            35                  40                  45                    

cga aag cag gcg att gcc gat gta ctg gcg aag tgc agc aag ggc atg        491
Arg Lys Gln Ala Ile Ala Asp Val Leu Ala Lys Cys Ser Lys Gly Met           
        50                  55                  60                        

gac ggc ctg gtg ctg tgc gcc ggc ctg gga ccg cag acc aag gtg ctt        539
Asp Gly Leu Val Leu Cys Ala Gly Leu Gly Pro Gln Thr Lys Val Leu           
    65                  70                  75                            

ggc aat gtg gtt tcg gtc aat tat ttt ggc gcg acc gag ctg atg gat        587
Gly Asn Val Val Ser Val Asn Tyr Phe Gly Ala Thr Glu Leu Met Asp           
80                  85                  90                  95            

gcc ttt ttg cca gcg ctg aaa aaa ggc cat cag ccc gca gcc gtc gtc        635
Ala Phe Leu Pro Ala Leu Lys Lys Gly His Gln Pro Ala Ala Val Val           
                100                 105                 110               

atc tcg tcc gtg gct tcc gcg cat ctg gct ttt gac aag aac cca ctg        683
Ile Ser Ser Val Ala Ser Ala His Leu Ala Phe Asp Lys Asn Pro Leu           
            115                 120                 125                   

gcg ctg gca ctg gaa gcc ggc gag gaa gcc aag gcc cgc gcc att gtc        731
Ala Leu Ala Leu Glu Ala Gly Glu Glu Ala Lys Ala Arg Ala Ile Val           
        130                 135                 140                       

gaa cat gcg gga gag cag ggc gga aat ctg gcc tat gcg ggc agc aag        779
Glu His Ala Gly Glu Gln Gly Gly Asn Leu Ala Tyr Ala Gly Ser Lys           
    145                 150                 155                           

aat gct ttg acg gtg gct gtg cgc aaa cgc gcc gcc gcc tgg ggc gag        827
Asn Ala Leu Thr Val Ala Val Arg Lys Arg Ala Ala Ala Trp Gly Glu           
160                 165                 170                 175           

gct ggc gtg cgc ctg aac acc atc gcc ccc ggt gca acc gag act ccc        875
Ala Gly Val Arg Leu Asn Thr Ile Ala Pro Gly Ala Thr Glu Thr Pro           
                180                 185                 190               

ttg ctg cag gcg ggc ctg cag gac ccg cgc tat ggc gaa tcc att gcc        923
Leu Leu Gln Ala Gly Leu Gln Asp Pro Arg Tyr Gly Glu Ser Ile Ala           
            195                 200                 205                   

aag ttc gtt cct ccc atg ggc cgc cgt gcc gag ccg tcc gag atg gcg        971
Lys Phe Val Pro Pro Met Gly Arg Arg Ala Glu Pro Ser Glu Met Ala           
        210                 215                 220                       

tcg gtc atc gcc ttt ttg atg agc ccg gcc gca agc tat gtg cat ggc       1019
Ser Val Ile Ala Phe Leu Met Ser Pro Ala Ala Ser Tyr Val His Gly           
    225                 230                 235                           

gcg cag atc gtc att gat ggc ggc att gat gcg gtg atg cgc ccg aca       1067
Ala Gln Ile Val Ile Asp Gly Gly Ile Asp Ala Val Met Arg Pro Thr           
240                 245                 250                 255           

cag ttc tga gaattcgagc tccgtcgaca agcttgcggc cgcactcgag               1116
Gln Phe                                                                   
                                                                          

caccaccacc accaccactg agatccggct gctaacaaag cccgaaagga agctgagttg     1176

gctgctgcca ccgctgagca ataactagca taaccccttg gggcctctaa acgggtcttg     1236

aggggttttt tgctgaaacc tcaggcattt gagaagcaca cggtcacact gcttccggta     1296

gtcaataaac cggtaaacca gcaatagaca taagcggcta tttaacgacc ctgccctgaa     1356

ccgacgacaa gctgacgacc gggtctccgc aagtggcact tttcggggaa atgtgcgcgg     1416

aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgaattaatt     1476

cttacgcccc gccctgccac tcatcgcagt actgttgtaa ttcattaagc attctgccga     1536

catggaagcc atcacagacg gcatgatgaa cctgaatcgc cagcggcatc agcaccttgt     1596

cgccttgcgt ataatatttg cctatggtga aaacgggggc gaagaagttg tccatattgg     1656

ccacgtttaa atcaaaactg gtgaaactca cccagggatt ggctgagacg aaaaacatat     1716

tctcaataaa ccctttaggg aaataggcca ggttttcacc gtaacacgcc acatcttgcg     1776

aatatatgtg tagaaactgc cggaaatcgt cgtggtattc actccagagc gatgaaaacg     1836

tttcagtttg ctcatggaaa acggtgtaac aagggtgaac actatcccat atcaccagct     1896

caccgtcttt cattgccata cggaattccg gatgagcatt catcaggcgg gcaagaatgt     1956

gaataaaggc cggataaaac ttgtgcttat ttttctttac ggtctttaaa aaggccgtaa     2016

tatccagctg aacggtctgg ttataggtac attgagcaac tgactgaaat gcctcaaaat     2076

gttctttacg atgccattgg gatatatcaa cggtggtata tccagtgatt tttttctcca     2136

tactcttcct ttttcaatat tattgaagca tttatcaggg ttattgtctc atgagcggat     2196

acatatttga atgtatttag aaaaataaac aaataggcat gctagcgcag aaacgtccta     2256

gaagatgcca ggaggatact tagcagagag acaataaggc cggagcgaag ccgtttttcc     2316

ataggctccg cccccctgac gaacatcacg aaatctgacg ctcaaatcag tggtggcgaa     2376

acccgacagg actataaaga taccaggcgt ttccccctga tggctccctc ttgcgctctc     2436

ctgttcccgt cctgcggcgt ccgtgttgtg gtggaggctt tacccaaatc accacgtccc     2496

gttccgtgta gacagttcgc tccaagctgg gctgtgtgca agaacccccc gttcagcccg     2556

actgctgcgc cttatccggt aactatcatc ttgagtccaa cccggaaaga cacgacaaaa     2616

cgccactggc agcagccatt ggtaactgag aattagtgga tttagatatc gagagtcttg     2676

aagtggtggc ctaacagagg ctacactgaa aggacagtat ttggtatctg cgctccacta     2736

aagccagtta ccaggttaag cagttcccca actgacttaa ccttcgatca aaccgcctcc     2796

ccaggcggtt ttttcgttta cagagcagga gattacgacg atcgtaaaag gatctcaaga     2856

agatccttta cggattcccg acaccatcac tctagatttc agtgcaattt atctcttcaa     2916

atgtagcacc tgaagtcagc cccatacgat ataagttgta attctcatgt tagtcatgcc     2976

ccgcgcccac cggaaggagc tgactgggtt gaaggctctc aagggcatcg gtcgagatcc     3036

cggtgcctaa tgagtgagct aacttacatt aattgcgttg cgctcactgc ccgctttcca     3096

gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg     3156

tttgcgtatt gggcgccagg gtggtttttc ttttcaccag tgagacgggc aacagctgat     3216

tgcccttcac cgcctggccc tgagagagtt gcagcaagcg gtccacgctg gtttgcccca     3276

gcaggcgaaa atcctgtttg atggtggtta acggcgggat ataacatgag ctgtcttcgg     3336

tatcgtcgta tcccactacc gagatgtccg caccaacgcg cagcccggac tcggtaatgg     3396

cgcgcattgc gcccagcgcc atctgatcgt tggcaaccag catcgcagtg ggaacgatgc     3456

cctcattcag catttgcatg gtttgttgaa aaccggacat ggcactccag tcgccttccc     3516

gttccgctat cggctgaatt tgattgcgag tgagatattt atgccagcca gccagacgca     3576

gacgcgccga gacagaactt aatgggcccg ctaacagcgc gatttgctgg tgacccaatg     3636

cgaccagatg ctccacgccc agtcgcgtac cgtcttcatg ggagaaaata atactgttga     3696

tgggtgtctg gtcagagaca tcaagaaata acgccggaac attagtgcag gcagcttcca     3756

cagcaatggc atcctggtca tccagcggat agttaatgat cagcccactg acgcgttgcg     3816

cgagaagatt gtgcaccgcc gctttacagg cttcgacgcc gcttcgttct accatcgaca     3876

ccaccacgct ggcacccagt tgatcggcgc gagatttaat cgccgcgaca atttgcgacg     3936

gcgcgtgcag ggccagactg gaggtggcaa cgccaatcag caacgactgt ttgcccgcca     3996

gttgttgtgc cacgcggttg ggaatgtaat tcagctccgc catcgccgct tccacttttt     4056

cccgcgtttt cgcagaaacg tggctggcct ggttcaccac gcgggaaacg gtctgataag     4116

agacaccggc atactctgcg acatcgtata acgttactgg tttcacattc accaccctga     4176

attgactctc ttccgggcgc tatcatgcca taccgcgaaa ggttttgcgc cattcgatgg     4236

tgtccgggat ctcgacgctc tcccttatgc gactcctgca ttaggaaatt aatacgactc     4296

actata                                                                4302


<210>  22
<211>  257
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  22

Met Ser Ile Ile Val Ile Ser Gly Cys Ala Thr Gly Ile Gly Ala Ala 
1               5                   10                  15      


Thr Arg Lys Val Leu Glu Ala Ala Gly His Gln Ile Val Gly Ile Asp 
            20                  25                  30          


Ile Arg Asp Ala Glu Val Ile Ala Asp Leu Ser Thr Ala Glu Gly Arg 
        35                  40                  45              


Lys Gln Ala Ile Ala Asp Val Leu Ala Lys Cys Ser Lys Gly Met Asp 
    50                  55                  60                  


Gly Leu Val Leu Cys Ala Gly Leu Gly Pro Gln Thr Lys Val Leu Gly 
65                  70                  75                  80  


Asn Val Val Ser Val Asn Tyr Phe Gly Ala Thr Glu Leu Met Asp Ala 
                85                  90                  95      


Phe Leu Pro Ala Leu Lys Lys Gly His Gln Pro Ala Ala Val Val Ile 
            100                 105                 110         


Ser Ser Val Ala Ser Ala His Leu Ala Phe Asp Lys Asn Pro Leu Ala 
        115                 120                 125             


Leu Ala Leu Glu Ala Gly Glu Glu Ala Lys Ala Arg Ala Ile Val Glu 
    130                 135                 140                 


His Ala Gly Glu Gln Gly Gly Asn Leu Ala Tyr Ala Gly Ser Lys Asn 
145                 150                 155                 160 


Ala Leu Thr Val Ala Val Arg Lys Arg Ala Ala Ala Trp Gly Glu Ala 
                165                 170                 175     


Gly Val Arg Leu Asn Thr Ile Ala Pro Gly Ala Thr Glu Thr Pro Leu 
            180                 185                 190         


Leu Gln Ala Gly Leu Gln Asp Pro Arg Tyr Gly Glu Ser Ile Ala Lys 
        195                 200                 205             


Phe Val Pro Pro Met Gly Arg Arg Ala Glu Pro Ser Glu Met Ala Ser 
    210                 215                 220                 


Val Ile Ala Phe Leu Met Ser Pro Ala Ala Ser Tyr Val His Gly Ala 
225                 230                 235                 240 


Gln Ile Val Ile Asp Gly Gly Ile Asp Ala Val Met Arg Pro Thr Gln 
                245                 250                 255     


Phe 
    


<210>  23
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  23
cgatcatatg gcaaaggtcc tgtgcgttc                                         29


<210>  24
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  24
gctagaattc tcagccgcct tcttgaact                                         29


<210>  25
<211>  768
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(768)

<400>  25
gtg ttt aat tct gac aac ctg aga ctc gac gga aaa tgc gcc atc atc         48
Val Phe Asn Ser Asp Asn Leu Arg Leu Asp Gly Lys Cys Ala Ile Ile           
1               5                   10                  15                

aca ggt gcg ggt gca ggt att ggt aaa gaa atc gcc att aca ttc gcg         96
Thr Gly Ala Gly Ala Gly Ile Gly Lys Glu Ile Ala Ile Thr Phe Ala           
            20                  25                  30                    

aca gct ggc gca tct gtg gtg gtc agt gat att aac gcc gac gca gct        144
Thr Ala Gly Ala Ser Val Val Val Ser Asp Ile Asn Ala Asp Ala Ala           
        35                  40                  45                        

aac cat gtt gta gac gaa att caa caa ctg ggt ggt cag gca ttt gcc        192
Asn His Val Val Asp Glu Ile Gln Gln Leu Gly Gly Gln Ala Phe Ala           
    50                  55                  60                            

tgc cgt tgt gat att act tcc gaa cag gaa ctc tct gca ctg gca gac        240
Cys Arg Cys Asp Ile Thr Ser Glu Gln Glu Leu Ser Ala Leu Ala Asp           
65                  70                  75                  80            

ttt gct atc agt aag ctg ggt aaa gtt gat att ctg gtt aac aac gcc        288
Phe Ala Ile Ser Lys Leu Gly Lys Val Asp Ile Leu Val Asn Asn Ala           
                85                  90                  95                

ggt ggc ggt gga cct aaa ccg ttt gat atg cca atg gcg gat ttt cgc        336
Gly Gly Gly Gly Pro Lys Pro Phe Asp Met Pro Met Ala Asp Phe Arg           
            100                 105                 110                   

cgt gct tat gaa ctg aat gtg ttt tct ttt ttc cat ctg tca caa ctt        384
Arg Ala Tyr Glu Leu Asn Val Phe Ser Phe Phe His Leu Ser Gln Leu           
        115                 120                 125                       

gtt gcg cca gaa atg gaa aaa aat ggc ggt ggc gtt att ctg acc atc        432
Val Ala Pro Glu Met Glu Lys Asn Gly Gly Gly Val Ile Leu Thr Ile           
    130                 135                 140                           

act tct atg gcg gca gaa aat aaa aat ata aac atg act tcc tat gca        480
Thr Ser Met Ala Ala Glu Asn Lys Asn Ile Asn Met Thr Ser Tyr Ala           
145                 150                 155                 160           

tca tct aaa gct gcg gcc agt cat ctg gtc aga aat atg gcg ttt gac        528
Ser Ser Lys Ala Ala Ala Ser His Leu Val Arg Asn Met Ala Phe Asp           
                165                 170                 175               

cta ggt gaa aaa aat att cgg gta aat ggc att gcg ccg ggg gca ata        576
Leu Gly Glu Lys Asn Ile Arg Val Asn Gly Ile Ala Pro Gly Ala Ile           
            180                 185                 190                   

tta acc gat gcc ctg aaa tcc gtt att aca cca gaa att gaa caa aaa        624
Leu Thr Asp Ala Leu Lys Ser Val Ile Thr Pro Glu Ile Glu Gln Lys           
        195                 200                 205                       

atg tta cag cac acg ccg atc aga cgt ctg ggc caa ccg caa gat att        672
Met Leu Gln His Thr Pro Ile Arg Arg Leu Gly Gln Pro Gln Asp Ile           
    210                 215                 220                           

gct aac gca gcg ctg ttc ctt tgc tcg cct gct gcg agc tgg gta agc        720
Ala Asn Ala Ala Leu Phe Leu Cys Ser Pro Ala Ala Ser Trp Val Ser           
225                 230                 235                 240           

gga caa att ctc acc gtc tcc ggt ggt ggg gta cag gag ctc aat taa        768
Gly Gln Ile Leu Thr Val Ser Gly Gly Gly Val Gln Glu Leu Asn               
                245                 250                 255               


<210>  26
<211>  255
<212>  PRT
<213>  Escherichia coli

<400>  26

Val Phe Asn Ser Asp Asn Leu Arg Leu Asp Gly Lys Cys Ala Ile Ile 
1               5                   10                  15      


Thr Gly Ala Gly Ala Gly Ile Gly Lys Glu Ile Ala Ile Thr Phe Ala 
            20                  25                  30          


Thr Ala Gly Ala Ser Val Val Val Ser Asp Ile Asn Ala Asp Ala Ala 
        35                  40                  45              


Asn His Val Val Asp Glu Ile Gln Gln Leu Gly Gly Gln Ala Phe Ala 
    50                  55                  60                  


Cys Arg Cys Asp Ile Thr Ser Glu Gln Glu Leu Ser Ala Leu Ala Asp 
65                  70                  75                  80  


Phe Ala Ile Ser Lys Leu Gly Lys Val Asp Ile Leu Val Asn Asn Ala 
                85                  90                  95      


Gly Gly Gly Gly Pro Lys Pro Phe Asp Met Pro Met Ala Asp Phe Arg 
            100                 105                 110         


Arg Ala Tyr Glu Leu Asn Val Phe Ser Phe Phe His Leu Ser Gln Leu 
        115                 120                 125             


Val Ala Pro Glu Met Glu Lys Asn Gly Gly Gly Val Ile Leu Thr Ile 
    130                 135                 140                 


Thr Ser Met Ala Ala Glu Asn Lys Asn Ile Asn Met Thr Ser Tyr Ala 
145                 150                 155                 160 


Ser Ser Lys Ala Ala Ala Ser His Leu Val Arg Asn Met Ala Phe Asp 
                165                 170                 175     


Leu Gly Glu Lys Asn Ile Arg Val Asn Gly Ile Ala Pro Gly Ala Ile 
            180                 185                 190         


Leu Thr Asp Ala Leu Lys Ser Val Ile Thr Pro Glu Ile Glu Gln Lys 
        195                 200                 205             


Met Leu Gln His Thr Pro Ile Arg Arg Leu Gly Gln Pro Gln Asp Ile 
    210                 215                 220                 


Ala Asn Ala Ala Leu Phe Leu Cys Ser Pro Ala Ala Ser Trp Val Ser 
225                 230                 235                 240 


Gly Gln Ile Leu Thr Val Ser Gly Gly Gly Val Gln Glu Leu Asn 
                245                 250                 255 


<210>  27
<211>  53
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  27
aaaaaagctt ataattatcc ttataggacg tcatggtgcg cccagatagg gtg              53


<210>  28
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  28
cagattgtac aaatgtggtg ataacagata agtcgtcatg tttaacttac ctttctttgt       60


<210>  29
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  29
tgaacgcaag tttctaattt cggtttccta tcgatagagg aaagtgtct                   49


<210>  30
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  30
cctgcactac accggccgtc accgcctgc                                         29


<210>  31
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  31
gctcgaattc tcagaccgcc ttc                                               23


<210>  32
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  32
ttaattgagc tcctgtaccc caccacc                                           27


<210>  33
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  33
gtgtttaatt ctgacaacct gagactcgac                                        30


<210>  34
<211>  1266
<212>  DNA
<213>  Artificial

<220>
<223>  FDH D221G Mutante mit His-Tag


<220>
<221>  CDS
<222>  (1)..(1266)

<400>  34
atg gca aag gtc ctg tgc gtt ctt tac gat gat ccg gtc gac ggc tac         48
Met Ala Lys Val Leu Cys Val Leu Tyr Asp Asp Pro Val Asp Gly Tyr           
1               5                   10                  15                

ccg aag acc tat gcc cgc gac gat ctt ccg aag atc gac cac tat ccg         96
Pro Lys Thr Tyr Ala Arg Asp Asp Leu Pro Lys Ile Asp His Tyr Pro           
            20                  25                  30                    

ggc ggc cag atc ttg ccg acg ccg aag gcc atc gac ttc acg ccc ggg        144
Gly Gly Gln Ile Leu Pro Thr Pro Lys Ala Ile Asp Phe Thr Pro Gly           
        35                  40                  45                        

cag ttg ctc ggc tcc gtc tcc ggc gag ctc ggc ctg cgc gaa tat ctc        192
Gln Leu Leu Gly Ser Val Ser Gly Glu Leu Gly Leu Arg Glu Tyr Leu           
    50                  55                  60                            

gaa tcc aac ggc cac acc ctg gtc gtg acc tcc gac aag gac ggc ccc        240
Glu Ser Asn Gly His Thr Leu Val Val Thr Ser Asp Lys Asp Gly Pro           
65                  70                  75                  80            

gac tcg gtg ttc gag cgc gag ctg gtc gat gcg gat gtc gtc atc tcc        288
Asp Ser Val Phe Glu Arg Glu Leu Val Asp Ala Asp Val Val Ile Ser           
                85                  90                  95                

cag ccc ttc tgg ccg gcc tat ctg acg ccc gag cgc atc gcc aag gcc        336
Gln Pro Phe Trp Pro Ala Tyr Leu Thr Pro Glu Arg Ile Ala Lys Ala           
            100                 105                 110                   

aag aac ctg aag ctc gcg ctc acc gcc ggc atc ggt tcc gac cac gtc        384
Lys Asn Leu Lys Leu Ala Leu Thr Ala Gly Ile Gly Ser Asp His Val           
        115                 120                 125                       

gat ctt cag tcg gct atc gac cgc aac gtc acc gtg gcg gaa gtc acc        432
Asp Leu Gln Ser Ala Ile Asp Arg Asn Val Thr Val Ala Glu Val Thr           
    130                 135                 140                           

tac tgc aac tcg atc agc gtc gcc gag cat gtg gtg atg atg atc ctg        480
Tyr Cys Asn Ser Ile Ser Val Ala Glu His Val Val Met Met Ile Leu           
145                 150                 155                 160           

tcg ctg gtg cgc aac tat ctg ccc tcg cac gaa tgg gcg cgg aag ggc        528
Ser Leu Val Arg Asn Tyr Leu Pro Ser His Glu Trp Ala Arg Lys Gly           
                165                 170                 175               

ggc tgg aac atc gcc gac tgc gtc tcc cac gcc tac gac ctc gag gcg        576
Gly Trp Asn Ile Ala Asp Cys Val Ser His Ala Tyr Asp Leu Glu Ala           
            180                 185                 190                   

atg cat gtc ggc acc gtg gcc gcc ggc cgc atc ggt ctc gcg gtg ctg        624
Met His Val Gly Thr Val Ala Ala Gly Arg Ile Gly Leu Ala Val Leu           
        195                 200                 205                       

cgc cgt ctg gcg ccg ttc gac gtg cac ctg cac tac acc ggc cgt cac        672
Arg Arg Leu Ala Pro Phe Asp Val His Leu His Tyr Thr Gly Arg His           
    210                 215                 220                           

cgc ctg ccg gaa tcg gtc gag aag gag ctc aac ctc acc tgg cac gcg        720
Arg Leu Pro Glu Ser Val Glu Lys Glu Leu Asn Leu Thr Trp His Ala           
225                 230                 235                 240           

acc cgc gag gac atg tat ccg gtt tgc gac gtg gtg acg ctg aac tgc        768
Thr Arg Glu Asp Met Tyr Pro Val Cys Asp Val Val Thr Leu Asn Cys           
                245                 250                 255               

ccg ctg cac ccc gaa acc gag cac atg atc aat gac gag acg ctg aag        816
Pro Leu His Pro Glu Thr Glu His Met Ile Asn Asp Glu Thr Leu Lys           
            260                 265                 270                   

ctg ttc aag cgt ggc gcc tac atc gtc aac acc gcc cgc ggc aag ctg        864
Leu Phe Lys Arg Gly Ala Tyr Ile Val Asn Thr Ala Arg Gly Lys Leu           
        275                 280                 285                       

tgc gac cgc gat gcc gtg gca cgt gcg ctc gaa tcc ggc cgg ctg gcc        912
Cys Asp Arg Asp Ala Val Ala Arg Ala Leu Glu Ser Gly Arg Leu Ala           
    290                 295                 300                           

ggc tat gcc ggc gac gtg tgg ttc ccg cag ccg gcg ccg aag gac cac        960
Gly Tyr Ala Gly Asp Val Trp Phe Pro Gln Pro Ala Pro Lys Asp His           
305                 310                 315                 320           

ccc tgg cgg acg atg ccc tat aac ggc atg acc ccg cac atc tcc ggc       1008
Pro Trp Arg Thr Met Pro Tyr Asn Gly Met Thr Pro His Ile Ser Gly           
                325                 330                 335               

acc acg ctg acc gcg cag gcg cgt tat gcg gcg ggc acc cgc gag atc       1056
Thr Thr Leu Thr Ala Gln Ala Arg Tyr Ala Ala Gly Thr Arg Glu Ile           
            340                 345                 350                   

ctg gag tgc ttc ttc gag ggc cgt ccg atc cgc gac gaa tac ctc atc       1104
Leu Glu Cys Phe Phe Glu Gly Arg Pro Ile Arg Asp Glu Tyr Leu Ile           
        355                 360                 365                       

gtg cag ggc ggc gct ctt gcc ggc acc ggc gcg cat tcc tac tcg aag       1152
Val Gln Gly Gly Ala Leu Ala Gly Thr Gly Ala His Ser Tyr Ser Lys           
    370                 375                 380                           

ggc aat gcc acc ggc ggt tcg gaa gag gcc gcc aag ttc aag aag gcg       1200
Gly Asn Ala Thr Gly Gly Ser Glu Glu Ala Ala Lys Phe Lys Lys Ala           
385                 390                 395                 400           

gct gag aat tcg agc tcc gtc gac aag ctt gcg gcc gca ctc gag cac       1248
Ala Glu Asn Ser Ser Ser Val Asp Lys Leu Ala Ala Ala Leu Glu His           
                405                 410                 415               

cac cac cac cac cac tga                                               1266
His His His His His                                                       
            420                                                           


<210>  35
<211>  421
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  35

Met Ala Lys Val Leu Cys Val Leu Tyr Asp Asp Pro Val Asp Gly Tyr 
1               5                   10                  15      


Pro Lys Thr Tyr Ala Arg Asp Asp Leu Pro Lys Ile Asp His Tyr Pro 
            20                  25                  30          


Gly Gly Gln Ile Leu Pro Thr Pro Lys Ala Ile Asp Phe Thr Pro Gly 
        35                  40                  45              


Gln Leu Leu Gly Ser Val Ser Gly Glu Leu Gly Leu Arg Glu Tyr Leu 
    50                  55                  60                  


Glu Ser Asn Gly His Thr Leu Val Val Thr Ser Asp Lys Asp Gly Pro 
65                  70                  75                  80  


Asp Ser Val Phe Glu Arg Glu Leu Val Asp Ala Asp Val Val Ile Ser 
                85                  90                  95      


Gln Pro Phe Trp Pro Ala Tyr Leu Thr Pro Glu Arg Ile Ala Lys Ala 
            100                 105                 110         


Lys Asn Leu Lys Leu Ala Leu Thr Ala Gly Ile Gly Ser Asp His Val 
        115                 120                 125             


Asp Leu Gln Ser Ala Ile Asp Arg Asn Val Thr Val Ala Glu Val Thr 
    130                 135                 140                 


Tyr Cys Asn Ser Ile Ser Val Ala Glu His Val Val Met Met Ile Leu 
145                 150                 155                 160 


Ser Leu Val Arg Asn Tyr Leu Pro Ser His Glu Trp Ala Arg Lys Gly 
                165                 170                 175     


Gly Trp Asn Ile Ala Asp Cys Val Ser His Ala Tyr Asp Leu Glu Ala 
            180                 185                 190         


Met His Val Gly Thr Val Ala Ala Gly Arg Ile Gly Leu Ala Val Leu 
        195                 200                 205             


Arg Arg Leu Ala Pro Phe Asp Val His Leu His Tyr Thr Gly Arg His 
    210                 215                 220                 


Arg Leu Pro Glu Ser Val Glu Lys Glu Leu Asn Leu Thr Trp His Ala 
225                 230                 235                 240 


Thr Arg Glu Asp Met Tyr Pro Val Cys Asp Val Val Thr Leu Asn Cys 
                245                 250                 255     


Pro Leu His Pro Glu Thr Glu His Met Ile Asn Asp Glu Thr Leu Lys 
            260                 265                 270         


Leu Phe Lys Arg Gly Ala Tyr Ile Val Asn Thr Ala Arg Gly Lys Leu 
        275                 280                 285             


Cys Asp Arg Asp Ala Val Ala Arg Ala Leu Glu Ser Gly Arg Leu Ala 
    290                 295                 300                 


Gly Tyr Ala Gly Asp Val Trp Phe Pro Gln Pro Ala Pro Lys Asp His 
305                 310                 315                 320 


Pro Trp Arg Thr Met Pro Tyr Asn Gly Met Thr Pro His Ile Ser Gly 
                325                 330                 335     


Thr Thr Leu Thr Ala Gln Ala Arg Tyr Ala Ala Gly Thr Arg Glu Ile 
            340                 345                 350         


Leu Glu Cys Phe Phe Glu Gly Arg Pro Ile Arg Asp Glu Tyr Leu Ile 
        355                 360                 365             


Val Gln Gly Gly Ala Leu Ala Gly Thr Gly Ala His Ser Tyr Ser Lys 
    370                 375                 380                 


Gly Asn Ala Thr Gly Gly Ser Glu Glu Ala Ala Lys Phe Lys Lys Ala 
385                 390                 395                 400 


Ala Glu Asn Ser Ser Ser Val Asp Lys Leu Ala Ala Ala Leu Glu His 
                405                 410                 415     


His His His His His 
            420     


<210>  36
<211>  401
<212>  PRT
<213>  Mycobacterium vaccae

<400>  36

Met Ala Lys Val Leu Cys Val Leu Tyr Asp Asp Pro Val Asp Gly Tyr 
1               5                   10                  15      


Pro Lys Thr Tyr Ala Arg Asp Asp Leu Pro Lys Ile Asp His Tyr Pro 
            20                  25                  30          


Gly Gly Gln Ile Leu Pro Thr Pro Lys Ala Ile Asp Phe Thr Pro Gly 
        35                  40                  45              


Gln Leu Leu Gly Ser Val Ser Gly Glu Leu Gly Leu Arg Glu Tyr Leu 
    50                  55                  60                  


Glu Ser Asn Gly His Thr Leu Val Val Thr Ser Asp Lys Asp Gly Pro 
65                  70                  75                  80  


Asp Ser Val Phe Glu Arg Glu Leu Val Asp Ala Asp Val Val Ile Ser 
                85                  90                  95      


Gln Pro Phe Trp Pro Ala Tyr Leu Thr Pro Glu Arg Ile Ala Lys Ala 
            100                 105                 110         


Lys Asn Leu Lys Leu Ala Leu Thr Ala Gly Ile Gly Ser Asp His Val 
        115                 120                 125             


Asp Leu Gln Ser Ala Ile Asp Arg Asn Val Thr Val Ala Glu Val Thr 
    130                 135                 140                 


Tyr Cys Asn Ser Ile Ser Val Ala Glu His Val Val Met Met Ile Leu 
145                 150                 155                 160 


Ser Leu Val Arg Asn Tyr Leu Pro Ser His Glu Trp Ala Arg Lys Gly 
                165                 170                 175     


Gly Trp Asn Ile Ala Asp Cys Val Ser His Ala Tyr Asp Leu Glu Ala 
            180                 185                 190         


Met His Val Gly Thr Val Ala Ala Gly Arg Ile Gly Leu Ala Val Leu 
        195                 200                 205             


Arg Arg Leu Ala Pro Phe Asp Val His Leu His Tyr Thr Asp Arg His 
    210                 215                 220                 


Arg Leu Pro Glu Ser Val Glu Lys Glu Leu Asn Leu Thr Trp His Ala 
225                 230                 235                 240 


Thr Arg Glu Asp Met Tyr Pro Val Cys Asp Val Val Thr Leu Asn Cys 
                245                 250                 255     


Pro Leu His Pro Glu Thr Glu His Met Ile Asn Asp Glu Thr Leu Lys 
            260                 265                 270         


Leu Phe Lys Arg Gly Ala Tyr Ile Val Asn Thr Ala Arg Gly Lys Leu 
        275                 280                 285             


Cys Asp Arg Asp Ala Val Ala Arg Ala Leu Glu Ser Gly Arg Leu Ala 
    290                 295                 300                 


Gly Tyr Ala Gly Asp Val Trp Phe Pro Gln Pro Ala Pro Lys Asp His 
305                 310                 315                 320 


Pro Trp Arg Thr Met Pro Tyr Asn Gly Met Thr Pro His Ile Ser Gly 
                325                 330                 335     


Thr Thr Leu Thr Ala Gln Ala Arg Tyr Ala Ala Gly Thr Arg Glu Ile 
            340                 345                 350         


Leu Glu Cys Phe Phe Glu Gly Arg Pro Ile Arg Asp Glu Tyr Leu Ile 
        355                 360                 365             


Val Gln Gly Gly Ala Leu Ala Gly Thr Gly Ala His Ser Tyr Ser Lys 
    370                 375                 380                 


Gly Asn Ala Thr Gly Gly Ser Glu Glu Ala Ala Lys Phe Lys Lys Ala 
385                 390                 395                 400 


Val 
    


<210>  37
<211>  263
<212>  PRT
<213>  artificial

<220>
<223>  abgeleitet aus Collinsella aerofaciens (G39D)

<400>  37

Met Asn Leu Arg Glu Lys Tyr Gly Glu Trp Gly Leu Ile Leu Gly Ala 
1               5                   10                  15      


Thr Glu Gly Val Gly Lys Ala Phe Cys Glu Lys Ile Ala Ala Gly Gly 
            20                  25                  30          


Met Asn Val Val Met Val Asp Arg Arg Glu Glu Lys Leu Asn Val Leu 
        35                  40                  45              


Ala Gly Glu Ile Arg Glu Thr Tyr Gly Val Glu Thr Lys Val Val Arg 
    50                  55                  60                  


Ala Asp Phe Ser Gln Pro Gly Ala Ala Glu Thr Val Phe Ala Ala Thr 
65                  70                  75                  80  


Glu Gly Leu Asp Met Gly Phe Met Ser Tyr Val Ala Cys Leu His Ser 
                85                  90                  95      


Phe Gly Lys Ile Gln Asp Thr Pro Trp Glu Lys His Glu Ala Met Ile 
            100                 105                 110         


Asn Val Asn Val Val Thr Phe Leu Lys Cys Phe His His Tyr Met Arg 
        115                 120                 125             


Ile Phe Ala Ala Gln Asp Arg Gly Ala Val Ile Asn Val Ser Ser Met 
    130                 135                 140                 


Thr Gly Ile Ser Ser Ser Pro Trp Asn Gly Gln Tyr Gly Ala Gly Lys 
145                 150                 155                 160 


Ala Phe Ile Leu Lys Met Thr Glu Ala Val Ala Cys Glu Cys Glu Gly 
                165                 170                 175     


Thr Gly Val Asp Val Glu Val Ile Thr Leu Gly Thr Thr Leu Thr Pro 
            180                 185                 190         


Ser Leu Leu Ser Asn Leu Pro Gly Gly Pro Gln Gly Glu Ala Val Met 
        195                 200                 205             


Lys Ile Ala Leu Thr Pro Glu Glu Cys Val Asp Glu Ala Phe Glu Lys 
    210                 215                 220                 


Leu Gly Lys Glu Leu Ser Val Ile Ala Gly Gln Arg Asn Lys Asp Ser 
225                 230                 235                 240 


Val His Asp Trp Lys Ala Asn His Thr Glu Asp Glu Tyr Ile Arg Tyr 
                245                 250                 255     


Met Gly Ser Phe Tyr Arg Asp 
            260             


<210>  38
<211>  263
<212>  PRT
<213>  artificial

<220>
<223>  abgeleitet aus Collinsella aerofaciens (G39D R40L)

<400>  38

Met Asn Leu Arg Glu Lys Tyr Gly Glu Trp Gly Leu Ile Leu Gly Ala 
1               5                   10                  15      


Thr Glu Gly Val Gly Lys Ala Phe Cys Glu Lys Ile Ala Ala Gly Gly 
            20                  25                  30          


Met Asn Val Val Met Val Asp Leu Arg Glu Glu Lys Leu Asn Val Leu 
        35                  40                  45              


Ala Gly Glu Ile Arg Glu Thr Tyr Gly Val Glu Thr Lys Val Val Arg 
    50                  55                  60                  


Ala Asp Phe Ser Gln Pro Gly Ala Ala Glu Thr Val Phe Ala Ala Thr 
65                  70                  75                  80  


Glu Gly Leu Asp Met Gly Phe Met Ser Tyr Val Ala Cys Leu His Ser 
                85                  90                  95      


Phe Gly Lys Ile Gln Asp Thr Pro Trp Glu Lys His Glu Ala Met Ile 
            100                 105                 110         


Asn Val Asn Val Val Thr Phe Leu Lys Cys Phe His His Tyr Met Arg 
        115                 120                 125             


Ile Phe Ala Ala Gln Asp Arg Gly Ala Val Ile Asn Val Ser Ser Met 
    130                 135                 140                 


Thr Gly Ile Ser Ser Ser Pro Trp Asn Gly Gln Tyr Gly Ala Gly Lys 
145                 150                 155                 160 


Ala Phe Ile Leu Lys Met Thr Glu Ala Val Ala Cys Glu Cys Glu Gly 
                165                 170                 175     


Thr Gly Val Asp Val Glu Val Ile Thr Leu Gly Thr Thr Leu Thr Pro 
            180                 185                 190         


Ser Leu Leu Ser Asn Leu Pro Gly Gly Pro Gln Gly Glu Ala Val Met 
        195                 200                 205             


Lys Ile Ala Leu Thr Pro Glu Glu Cys Val Asp Glu Ala Phe Glu Lys 
    210                 215                 220                 


Leu Gly Lys Glu Leu Ser Val Ile Ala Gly Gln Arg Asn Lys Asp Ser 
225                 230                 235                 240 


Val His Asp Trp Lys Ala Asn His Thr Glu Asp Glu Tyr Ile Arg Tyr 
                245                 250                 255     


Met Gly Ser Phe Tyr Arg Asp 
            260             


<210>  39
<211>  263
<212>  PRT
<213>  artificial

<220>
<223>  abegleitet aus Collinsella aerofaciens (G39D R40I)

<400>  39

Met Asn Leu Arg Glu Lys Tyr Gly Glu Trp Gly Leu Ile Leu Gly Ala 
1               5                   10                  15      


Thr Glu Gly Val Gly Lys Ala Phe Cys Glu Lys Ile Ala Ala Gly Gly 
            20                  25                  30          


Met Asn Val Val Met Val Asp Ile Arg Glu Glu Lys Leu Asn Val Leu 
        35                  40                  45              


Ala Gly Glu Ile Arg Glu Thr Tyr Gly Val Glu Thr Lys Val Val Arg 
    50                  55                  60                  


Ala Asp Phe Ser Gln Pro Gly Ala Ala Glu Thr Val Phe Ala Ala Thr 
65                  70                  75                  80  


Glu Gly Leu Asp Met Gly Phe Met Ser Tyr Val Ala Cys Leu His Ser 
                85                  90                  95      


Phe Gly Lys Ile Gln Asp Thr Pro Trp Glu Lys His Glu Ala Met Ile 
            100                 105                 110         


Asn Val Asn Val Val Thr Phe Leu Lys Cys Phe His His Tyr Met Arg 
        115                 120                 125             


Ile Phe Ala Ala Gln Asp Arg Gly Ala Val Ile Asn Val Ser Ser Met 
    130                 135                 140                 


Thr Gly Ile Ser Ser Ser Pro Trp Asn Gly Gln Tyr Gly Ala Gly Lys 
145                 150                 155                 160 


Ala Phe Ile Leu Lys Met Thr Glu Ala Val Ala Cys Glu Cys Glu Gly 
                165                 170                 175     


Thr Gly Val Asp Val Glu Val Ile Thr Leu Gly Thr Thr Leu Thr Pro 
            180                 185                 190         


Ser Leu Leu Ser Asn Leu Pro Gly Gly Pro Gln Gly Glu Ala Val Met 
        195                 200                 205             


Lys Ile Ala Leu Thr Pro Glu Glu Cys Val Asp Glu Ala Phe Glu Lys 
    210                 215                 220                 


Leu Gly Lys Glu Leu Ser Val Ile Ala Gly Gln Arg Asn Lys Asp Ser 
225                 230                 235                 240 


Val His Asp Trp Lys Ala Asn His Thr Glu Asp Glu Tyr Ile Arg Tyr 
                245                 250                 255     


Met Gly Ser Phe Tyr Arg Asp 
            260             


<210>  40
<211>  263
<212>  PRT
<213>  artificial

<220>
<223>  abgeleitet aus Collinsella aerofaciens

<400>  40

Met Asn Leu Arg Glu Lys Tyr Gly Glu Trp Gly Leu Ile Leu Gly Ala 
1               5                   10                  15      


Thr Glu Gly Val Gly Lys Ala Phe Cys Glu Lys Ile Ala Ala Gly Gly 
            20                  25                  30          


Met Asn Val Val Met Val Asp Val Arg Glu Glu Lys Leu Asn Val Leu 
        35                  40                  45              


Ala Gly Glu Ile Arg Glu Thr Tyr Gly Val Glu Thr Lys Val Val Arg 
    50                  55                  60                  


Ala Asp Phe Ser Gln Pro Gly Ala Ala Glu Thr Val Phe Ala Ala Thr 
65                  70                  75                  80  


Glu Gly Leu Asp Met Gly Phe Met Ser Tyr Val Ala Cys Leu His Ser 
                85                  90                  95      


Phe Gly Lys Ile Gln Asp Thr Pro Trp Glu Lys His Glu Ala Met Ile 
            100                 105                 110         


Asn Val Asn Val Val Thr Phe Leu Lys Cys Phe His His Tyr Met Arg 
        115                 120                 125             


Ile Phe Ala Ala Gln Asp Arg Gly Ala Val Ile Asn Val Ser Ser Met 
    130                 135                 140                 


Thr Gly Ile Ser Ser Ser Pro Trp Asn Gly Gln Tyr Gly Ala Gly Lys 
145                 150                 155                 160 


Ala Phe Ile Leu Lys Met Thr Glu Ala Val Ala Cys Glu Cys Glu Gly 
                165                 170                 175     


Thr Gly Val Asp Val Glu Val Ile Thr Leu Gly Thr Thr Leu Thr Pro 
            180                 185                 190         


Ser Leu Leu Ser Asn Leu Pro Gly Gly Pro Gln Gly Glu Ala Val Met 
        195                 200                 205             


Lys Ile Ala Leu Thr Pro Glu Glu Cys Val Asp Glu Ala Phe Glu Lys 
    210                 215                 220                 


Leu Gly Lys Glu Leu Ser Val Ile Ala Gly Gln Arg Asn Lys Asp Ser 
225                 230                 235                 240 


Val His Asp Trp Lys Ala Asn His Thr Glu Asp Glu Tyr Ile Arg Tyr 
                245                 250                 255     


Met Gly Ser Phe Tyr Arg Asp 
            260             


<210>  41
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  PCR Primer

<400>  41
cgtcgtcatg gtcgaccgtc gcgagg                                            26


<210>  42
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  PCR Primer

<400>  42
cctcgcgacg gtcgaccatg acgacg                                            26


<210>  43
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  PCR Primer

<400>  43
cgtcgtcatg gtcgacctgc gcgagg                                            26


<210>  44
<211>  31
<212>  DNA
<213>  artificial

<220>
<223>  PCR Primer

<400>  44
ccgccgcatc cataccgcca gttgtttacc c                                      31


<210>  45
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  PCR Primer

<400>  45
cgtcgtcatg gtcgacattc gcgagg                                            26


<210>  46
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  PCR Primer

<400>  46
cgtcgtcatg gtcgacgttc gcgagg                                            26


<210>  47
<211>  786
<212>  DNA
<213>  Bacillus subtilis

<400>  47
atgtatccgg atttaaaagg aaaagtcgtc gctattacag gagctgcttc agggctcgga       60

aaggcgatgg ccattcgctt cggcaaggag caggcaaaag tggttatcaa ctattatagt      120

aataaacaag atccgaacga ggtaaaagaa gaggtcatca aggcgggcgg tgaagctgtt      180

gtcgtccaag gagatgtcac gaaagaggaa gatgtaaaaa atatcgtgca aacggcaatt      240

aaggagttcg gcacactcga tattatgatt aataatgccg gtcttgaaaa tcctgtgcca      300

tctcacgaaa tgccgctcaa ggattgggat aaagtcatcg gcacgaactt aacgggtgcc      360

tttttaggaa gccgtgaagc gattaaatat ttcgtagaaa acgatatcaa gggaaatgtc      420

attaacatgt ccagtgtgca cgaagtgatt ccttggccgt tatttgtcca ctatgcggca      480

agtaaaggcg ggataaagct gatgacagaa acattagcgt tggaatacgc gccgaagggc      540

attcgcgtca ataatattgg gccaggtgcg atcaacacgc caatcaatgc tgaaaaattc      600

gctgacccta aacagaaagc tgatgtagaa agcatgattc caatgggata tatcggcgaa      660

ccggaggaga tcgccgcagt agcagcctgg cttgcttcga aggaagccag ctacgtcaca      720

ggcatcacgt tattcgcgga cggcggtatg acacaatatc cttcattcca ggcaggccgc      780

ggttaa                                                                 786


<210>  48
<211>  261
<212>  PRT
<213>  Bacillus subtilis

<400>  48

Met Tyr Pro Asp Leu Lys Gly Lys Val Val Ala Ile Thr Gly Ala Ala 
1               5                   10                  15      


Ser Gly Leu Gly Lys Ala Met Ala Ile Arg Phe Gly Lys Glu Gln Ala 
            20                  25                  30          


Lys Val Val Ile Asn Tyr Tyr Ser Asn Lys Gln Asp Pro Asn Glu Val 
        35                  40                  45              


Lys Glu Glu Val Ile Lys Ala Gly Gly Glu Ala Val Val Val Gln Gly 
    50                  55                  60                  


Asp Val Thr Lys Glu Glu Asp Val Lys Asn Ile Val Gln Thr Ala Ile 
65                  70                  75                  80  


Lys Glu Phe Gly Thr Leu Asp Ile Met Ile Asn Asn Ala Gly Leu Glu 
                85                  90                  95      


Asn Pro Val Pro Ser His Glu Met Pro Leu Lys Asp Trp Asp Lys Val 
            100                 105                 110         


Ile Gly Thr Asn Leu Thr Gly Ala Phe Leu Gly Ser Arg Glu Ala Ile 
        115                 120                 125             


Lys Tyr Phe Val Glu Asn Asp Ile Lys Gly Asn Val Ile Asn Met Ser 
    130                 135                 140                 


Ser Val His Glu Val Ile Pro Trp Pro Leu Phe Val His Tyr Ala Ala 
145                 150                 155                 160 


Ser Lys Gly Gly Ile Lys Leu Met Thr Glu Thr Leu Ala Leu Glu Tyr 
                165                 170                 175     


Ala Pro Lys Gly Ile Arg Val Asn Asn Ile Gly Pro Gly Ala Ile Asn 
            180                 185                 190         


Thr Pro Ile Asn Ala Glu Lys Phe Ala Asp Pro Lys Gln Lys Ala Asp 
        195                 200                 205             


Val Glu Ser Met Ile Pro Met Gly Tyr Ile Gly Glu Pro Glu Glu Ile 
    210                 215                 220                 


Ala Ala Val Ala Ala Trp Leu Ala Ser Lys Glu Ala Ser Tyr Val Thr 
225                 230                 235                 240 


Gly Ile Thr Leu Phe Ala Asp Gly Gly Met Thr Gln Tyr Pro Ser Phe 
                245                 250                 255     


Gln Ala Gly Arg Gly 
            260     


<210>  49
<211>  7404
<212>  DNA
<213>  artificial

<220>
<223>  Vektor pFr7(D)

<400>  49
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagtgcggcc gcaagcttct      180

agtcgcggta gaacgacccc atgtagcgga tgtactcgtc ctcggtgtgg tttgccttcc      240

agtcgtggac ggagtccttg ttgcgctggc cggcgatgac ggagagctcc ttacccagct      300

tctcaaaggc ctcgtcaacg cactcctcgg gggtgagggc gatcttcatg acggcctcgc      360

cctgcgggcc gccggggagg ttggacagca ggctgggggt tagggtggtg ccgagggtga      420

tgacctcgac gtcgacgccg gtgccctcgc actcgcaggc cacggcctcg gtcatcttga      480

ggatgaaggc cttgcccgcg ccgtactggc cgttccaggg gctggagctg atgccggtca      540

tcgacgagac gttgatcacg gcgccgcggt cctgggcggc aaagatccgc atgtagtggt      600

ggaagcactt gaggaaggtc acgacgttga cgttgatcat ggcctcgtgc ttctcccagg      660

gggtgtcctg gatcttaccg aagctgtgca ggcaggccac gtagctcatg aagcccatgt      720

ccaggccctc ggtcgcggcg aagacggtct cggcagcgcc gggctggcta aagtcggcgc      780

gcacgacctt ggtctccacg ccgtaggtct cgcggatctc gcctgcgagc acgttcagct      840

tctcctcgcg acggtcgacc atgacgacgt tcatgccgcc ggcggcgatc ttctcgcaga      900

acgccttgcc gacgccctcg gtcgcgccca ggatcaggcc ccactcaccg tacttctccc      960

tcaggttcat gtatatctcc tttcacgaat tctcagccgc cttcttgaac ttggcggcct     1020

cttccgaacc gccggtggca ttgcccttcg agtaggaatg cgcgccggtg ccggcaagag     1080

cgccgccctg cacgatgagg tattcgtcgc ggatcggacg gccctcgaag aagcactcca     1140

ggatctcgcg ggtgcccgcc gcataacgcg cctgcgcggt cagcgtggtg ccggagatgt     1200

gcggggtcat gccgttatag ggcatcgtcc gccaggggtg gtccttcggc gccggctgcg     1260

ggaaccacac gtcgccggca tagccggcca gccggccgga ttcgagcgca cgtgccacgg     1320

catcgcggtc gcacagcttg ccgcgggcgg tgttgacgat gtaggcgcca cgcttgaaca     1380

gcttcagcgt ctcgtcattg atcatgtgct cggtttcggg gtgcagcggg cagttcagcg     1440

tcaccacgtc gcaaaccgga tacatgtcct cgcgggtcgc gtgccaggtg aggttgagct     1500

ccttctcgac cgattccggc aggcggtgac ggccggtgta gtgcaggtgc acgtcgaacg     1560

gcgccagacg gcgcagcacc gcgagaccga tgcggccggc ggccacggtg ccgacatgca     1620

tcgcctcgag gtcgtaggcg tgggagacgc agtcggcgat gttccagccg cccttccgcg     1680

cccattcgtg cgagggcaga tagttgcgca ccagcgacag gatcatcatc accacatgct     1740

cggcgacgct gatcgagttg cagtaggtga cttccgccac ggtgacgttg cggtcgatag     1800

ccgactgaag atcgacgtgg tcggaaccga tgccggcggt gagcgcgagc ttcaggttct     1860

tggccttggc gatgcgctcg ggcgtcagat aggccggcca gaagggctgg gagatgacga     1920

catccgcatc gaccagctcg cgctcgaaca ccgagtcggg gccgtccttg tcggaggtca     1980

cgaccagggt gtggccgttg gattcgagat attcgcgcag gccgagctcg ccggagacgg     2040

agccgagcaa ctgcccgggc gtgaagtcga tggccttcgg cgtcggcaag atctggccgc     2100

ccggatagtg gtcgatcttc ggaagatcgt cgcgggcata ggtcttcggg tagccgtcga     2160

ccggatcatc gtaaagaacg cacaggacct ttgccatcat atgtatatct ccttcttaaa     2220

gttaaacaaa attatttcta gaggggaatt gttatccgct cacaattccc ctatagtgag     2280

tcgtattaat ttcgcgggat cgagatctcg atcctctacg ccggacgcat cgtggccggc     2340

atcaccggcg ccacaggtgc ggttgctggc gcctatatcg ccgacatcac cgatggggaa     2400

gatcgggctc gccacttcgg gctcatgagc gcttgtttcg gcgtgggtat ggtggcaggc     2460

cccgtggccg ggggactgtt gggcgccatc tccttgcatg caccattcct tgcggcggcg     2520

gtgctcaacg gcctcaacct actactgggc tgcttcctaa tgcaggagtc gcataaggga     2580

gagcgtcgag atcccggaca ccatcgaatg gcgcaaaacc tttcgcggta tggcatgata     2640

gcgcccggaa gagagtcaat tcagggtggt gaatgtgaaa ccagtaacgt tatacgatgt     2700

cgcagagtat gccggtgtct cttatcagac cgtttcccgc gtggtgaacc aggccagcca     2760

cgtttctgcg aaaacgcggg aaaaagtgga agcggcgatg gcggagctga attacattcc     2820

caaccgcgtg gcacaacaac tggcgggcaa acagtcgttg ctgattggcg ttgccacctc     2880

cagtctggcc ctgcacgcgc cgtcgcaaat tgtcgcggcg attaaatctc gcgccgatca     2940

actgggtgcc agcgtggtgg tgtcgatggt agaacgaagc ggcgtcgaag cctgtaaagc     3000

ggcggtgcac aatcttctcg cgcaacgcgt cagtgggctg atcattaact atccgctgga     3060

tgaccaggat gccattgctg tggaagctgc ctgcactaat gttccggcgt tatttcttga     3120

tgtctctgac cagacaccca tcaacagtat tattttctcc catgaagacg gtacgcgact     3180

gggcgtggag catctggtcg cattgggtca ccagcaaatc gcgctgttag cgggcccatt     3240

aagttctgtc tcggcgcgtc tgcgtctggc tggctggcat aaatatctca ctcgcaatca     3300

aattcagccg atagcggaac gggaaggcga ctggagtgcc atgtccggtt ttcaacaaac     3360

catgcaaatg ctgaatgagg gcatcgttcc cactgcgatg ctggttgcca acgatcagat     3420

ggcgctgggc gcaatgcgcg ccattaccga gtccgggctg cgcgttggtg cggatatctc     3480

ggtagtggga tacgacgata ccgaagacag ctcatgttat atcccgccgt taaccaccat     3540

caaacaggat tttcgcctgc tggggcaaac cagcgtggac cgcttgctgc aactctctca     3600

gggccaggcg gtgaagggca atcagctgtt gcccgtctca ctggtgaaaa gaaaaaccac     3660

cctggcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct     3720

ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtaagtt     3780

agctcactca ttaggcaccg ggatctcgac cgatgccctt gagagccttc aacccagtca     3840

gctccttccg gtgggcgcgg ggcatgacta tcgtcgccgc acttatgact gtcttcttta     3900

tcatgcaact cgtaggacag gtgccggcag cgctctgggt cattttcggc gaggaccgct     3960

ttcgctggag cgcgacgatg atcggcctgt cgcttgcggt attcggaatc ttgcacgccc     4020

tcgctcaagc cttcgtcact ggtcccgcca ccaaacgttt cggcgagaag caggccatta     4080

tcgccggcat ggcggcccca cgggtgcgca tgatcgtgct cctgtcgttg aggacccggc     4140

taggctggcg gggttgcctt actggttagc agaatgaatc accgatacgc gagcgaacgt     4200

gaagcgactg ctgctgcaaa acgtctgcga cctgagcaac aacatgaatg gtcttcggtt     4260

tccgtgtttc gtaaagtctg gaaacgcgga agtcagcgcc ctgcaccatt atgttccgga     4320

tctgcatcgc aggatgctgc tggctaccct gtggaacacc tacatctgta ttaacgaagc     4380

gctggcattg accctgagtg atttttctct ggtcccgccg catccatacc gccagttgtt     4440

taccctcaca acgttccagt aaccgggcat gttcatcatc agtaacccgt atcgtgagca     4500

tcctctctcg tttcatcggt atcattaccc ccatgaacag aaatccccct tacacggagg     4560

catcagtgac caaacaggaa aaaaccgccc ttaacatggc ccgctttatc agaagccaga     4620

cattaacgct tctggagaaa ctcaacgagc tggacgcgga tgaacaggca gacatctgtg     4680

aatcgcttca cgaccacgct gatgagcttt accgcagctg cctcgcgcgt ttcggtgatg     4740

acggtgaaaa cctctgacac atgcagctcc cggagacggt cacagcttgt ctgtaagcgg     4800

atgccgggag cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg tgtcggggcg     4860

cagccatgac ccagtcacgt agcgatagcg gagtgtatac tggcttaact atgcggcatc     4920

agagcagatt gtactgagag tgcaccatat atgcggtgtg aaataccgca cagatgcgta     4980

aggagaaaat accgcatcag gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg     5040

gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca     5100

gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac     5160

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     5220

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     5280

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     5340

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat     5400

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     5460

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac     5520

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt     5580

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaaggac agtatttggt     5640

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc     5700

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga     5760

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac     5820

gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc     5880

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct     5940

gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca     6000

tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct     6060

ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca     6120

ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc     6180

atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg     6240

cgcaacgttg ttgccattgc tgcaggcatc gtggtgtcac gctcgtcgtt tggtatggct     6300

tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa     6360

aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta     6420

tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc     6480

ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg     6540

agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa     6600

gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg     6660

agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc     6720

accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg     6780

gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat     6840

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     6900

ggggttccgc gcacatttcc ccgaaaagtg ccacctgaaa ttgtaaacgt taatattttg     6960

ttaaaattcg cgttaaattt ttgttaaatc agctcatttt ttaaccaata ggccgaaatc     7020

ggcaaaatcc cttataaatc aaaagaatag accgagatag ggttgagtgt tgttccagtt     7080

tggaacaaga gtccactatt aaagaacgtg gactccaacg tcaaagggcg aaaaaccgtc     7140

tatcagggcg atggcccact acgtgaacca tcaccctaat caagtttttt ggggtcgagg     7200

tgccgtaaag cactaaatcg gaaccctaaa gggagccccc gatttagagc ttgacgggga     7260

aagccggcga acgtggcgag aaaggaaggg aagaaagcga aaggagcggg cgctagggcg     7320

ctggcaagtg tagcggtcac gctgcgcgta accaccacac ccgccgcgct taatgcgccg     7380

ctacagggcg cgtcccattc gcca                                            7404


<210>  50
<211>  7404
<212>  DNA
<213>  artificial

<220>
<223>  Vektor pFr7(DL)

<400>  50
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagtgcggcc gcaagcttct      180

agtcgcggta gaacgacccc atgtagcgga tgtactcgtc ctcggtgtgg tttgccttcc      240

agtcgtggac ggagtccttg ttgcgctggc cggcgatgac ggagagctcc ttacccagct      300

tctcaaaggc ctcgtcaacg cactcctcgg gggtgagggc gatcttcatg acggcctcgc      360

cctgcgggcc gccggggagg ttggacagca ggctgggggt tagggtggtg ccgagggtga      420

tgacctcgac gtcgacgccg gtgccctcgc actcgcaggc cacggcctcg gtcatcttga      480

ggatgaaggc cttgcccgcg ccgtactggc cgttccaggg gctggagctg atgccggtca      540

tcgacgagac gttgatcacg gcgccgcggt cctgggcggc aaagatccgc atgtagtggt      600

ggaagcactt gaggaaggtc acgacgttga cgttgatcat ggcctcgtgc ttctcccagg      660

gggtgtcctg gatcttaccg aagctgtgca ggcaggccac gtagctcatg aagcccatgt      720

ccaggccctc ggtcgcggcg aagacggtct cggcagcgcc gggctggcta aagtcggcgc      780

gcacgacctt ggtctccacg ccgtaggtct cgcggatctc gcctgcgagc acgttcagct      840

tctcctcgcg caggtcgacc atgacgacgt tcatgccgcc ggcggcgatc ttctcgcaga      900

acgccttgcc gacgccctcg gtcgcgccca ggatcaggcc ccactcaccg tacttctccc      960

tcaggttcat gtatatctcc tttcacgaat tctcagccgc cttcttgaac ttggcggcct     1020

cttccgaacc gccggtggca ttgcccttcg agtaggaatg cgcgccggtg ccggcaagag     1080

cgccgccctg cacgatgagg tattcgtcgc ggatcggacg gccctcgaag aagcactcca     1140

ggatctcgcg ggtgcccgcc gcataacgcg cctgcgcggt cagcgtggtg ccggagatgt     1200

gcggggtcat gccgttatag ggcatcgtcc gccaggggtg gtccttcggc gccggctgcg     1260

ggaaccacac gtcgccggca tagccggcca gccggccgga ttcgagcgca cgtgccacgg     1320

catcgcggtc gcacagcttg ccgcgggcgg tgttgacgat gtaggcgcca cgcttgaaca     1380

gcttcagcgt ctcgtcattg atcatgtgct cggtttcggg gtgcagcggg cagttcagcg     1440

tcaccacgtc gcaaaccgga tacatgtcct cgcgggtcgc gtgccaggtg aggttgagct     1500

ccttctcgac cgattccggc aggcggtgac ggccggtgta gtgcaggtgc acgtcgaacg     1560

gcgccagacg gcgcagcacc gcgagaccga tgcggccggc ggccacggtg ccgacatgca     1620

tcgcctcgag gtcgtaggcg tgggagacgc agtcggcgat gttccagccg cccttccgcg     1680

cccattcgtg cgagggcaga tagttgcgca ccagcgacag gatcatcatc accacatgct     1740

cggcgacgct gatcgagttg cagtaggtga cttccgccac ggtgacgttg cggtcgatag     1800

ccgactgaag atcgacgtgg tcggaaccga tgccggcggt gagcgcgagc ttcaggttct     1860

tggccttggc gatgcgctcg ggcgtcagat aggccggcca gaagggctgg gagatgacga     1920

catccgcatc gaccagctcg cgctcgaaca ccgagtcggg gccgtccttg tcggaggtca     1980

cgaccagggt gtggccgttg gattcgagat attcgcgcag gccgagctcg ccggagacgg     2040

agccgagcaa ctgcccgggc gtgaagtcga tggccttcgg cgtcggcaag atctggccgc     2100

ccggatagtg gtcgatcttc ggaagatcgt cgcgggcata ggtcttcggg tagccgtcga     2160

ccggatcatc gtaaagaacg cacaggacct ttgccatcat atgtatatct ccttcttaaa     2220

gttaaacaaa attatttcta gaggggaatt gttatccgct cacaattccc ctatagtgag     2280

tcgtattaat ttcgcgggat cgagatctcg atcctctacg ccggacgcat cgtggccggc     2340

atcaccggcg ccacaggtgc ggttgctggc gcctatatcg ccgacatcac cgatggggaa     2400

gatcgggctc gccacttcgg gctcatgagc gcttgtttcg gcgtgggtat ggtggcaggc     2460

cccgtggccg ggggactgtt gggcgccatc tccttgcatg caccattcct tgcggcggcg     2520

gtgctcaacg gcctcaacct actactgggc tgcttcctaa tgcaggagtc gcataaggga     2580

gagcgtcgag atcccggaca ccatcgaatg gcgcaaaacc tttcgcggta tggcatgata     2640

gcgcccggaa gagagtcaat tcagggtggt gaatgtgaaa ccagtaacgt tatacgatgt     2700

cgcagagtat gccggtgtct cttatcagac cgtttcccgc gtggtgaacc aggccagcca     2760

cgtttctgcg aaaacgcggg aaaaagtgga agcggcgatg gcggagctga attacattcc     2820

caaccgcgtg gcacaacaac tggcgggcaa acagtcgttg ctgattggcg ttgccacctc     2880

cagtctggcc ctgcacgcgc cgtcgcaaat tgtcgcggcg attaaatctc gcgccgatca     2940

actgggtgcc agcgtggtgg tgtcgatggt agaacgaagc ggcgtcgaag cctgtaaagc     3000

ggcggtgcac aatcttctcg cgcaacgcgt cagtgggctg atcattaact atccgctgga     3060

tgaccaggat gccattgctg tggaagctgc ctgcactaat gttccggcgt tatttcttga     3120

tgtctctgac cagacaccca tcaacagtat tattttctcc catgaagacg gtacgcgact     3180

gggcgtggag catctggtcg cattgggtca ccagcaaatc gcgctgttag cgggcccatt     3240

aagttctgtc tcggcgcgtc tgcgtctggc tggctggcat aaatatctca ctcgcaatca     3300

aattcagccg atagcggaac gggaaggcga ctggagtgcc atgtccggtt ttcaacaaac     3360

catgcaaatg ctgaatgagg gcatcgttcc cactgcgatg ctggttgcca acgatcagat     3420

ggcgctgggc gcaatgcgcg ccattaccga gtccgggctg cgcgttggtg cggatatctc     3480

ggtagtggga tacgacgata ccgaagacag ctcatgttat atcccgccgt taaccaccat     3540

caaacaggat tttcgcctgc tggggcaaac cagcgtggac cgcttgctgc aactctctca     3600

gggccaggcg gtgaagggca atcagctgtt gcccgtctca ctggtgaaaa gaaaaaccac     3660

cctggcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct     3720

ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtaagtt     3780

agctcactca ttaggcaccg ggatctcgac cgatgccctt gagagccttc aacccagtca     3840

gctccttccg gtgggcgcgg ggcatgacta tcgtcgccgc acttatgact gtcttcttta     3900

tcatgcaact cgtaggacag gtgccggcag cgctctgggt cattttcggc gaggaccgct     3960

ttcgctggag cgcgacgatg atcggcctgt cgcttgcggt attcggaatc ttgcacgccc     4020

tcgctcaagc cttcgtcact ggtcccgcca ccaaacgttt cggcgagaag caggccatta     4080

tcgccggcat ggcggcccca cgggtgcgca tgatcgtgct cctgtcgttg aggacccggc     4140

taggctggcg gggttgcctt actggttagc agaatgaatc accgatacgc gagcgaacgt     4200

gaagcgactg ctgctgcaaa acgtctgcga cctgagcaac aacatgaatg gtcttcggtt     4260

tccgtgtttc gtaaagtctg gaaacgcgga agtcagcgcc ctgcaccatt atgttccgga     4320

tctgcatcgc aggatgctgc tggctaccct gtggaacacc tacatctgta ttaacgaagc     4380

gctggcattg accctgagtg atttttctct ggtcccgccg catccatacc gccagttgtt     4440

taccctcaca acgttccagt aaccgggcat gttcatcatc agtaacccgt atcgtgagca     4500

tcctctctcg tttcatcggt atcattaccc ccatgaacag aaatccccct tacacggagg     4560

catcagtgac caaacaggaa aaaaccgccc ttaacatggc ccgctttatc agaagccaga     4620

cattaacgct tctggagaaa ctcaacgagc tggacgcgga tgaacaggca gacatctgtg     4680

aatcgcttca cgaccacgct gatgagcttt accgcagctg cctcgcgcgt ttcggtgatg     4740

acggtgaaaa cctctgacac atgcagctcc cggagacggt cacagcttgt ctgtaagcgg     4800

atgccgggag cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg tgtcggggcg     4860

cagccatgac ccagtcacgt agcgatagcg gagtgtatac tggcttaact atgcggcatc     4920

agagcagatt gtactgagag tgcaccatat atgcggtgtg aaataccgca cagatgcgta     4980

aggagaaaat accgcatcag gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg     5040

gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca     5100

gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac     5160

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     5220

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     5280

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     5340

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat     5400

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     5460

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac     5520

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt     5580

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaaggac agtatttggt     5640

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc     5700

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga     5760

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac     5820

gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc     5880

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct     5940

gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca     6000

tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct     6060

ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca     6120

ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc     6180

atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg     6240

cgcaacgttg ttgccattgc tgcaggcatc gtggtgtcac gctcgtcgtt tggtatggct     6300

tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa     6360

aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta     6420

tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc     6480

ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg     6540

agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa     6600

gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg     6660

agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc     6720

accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg     6780

gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat     6840

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     6900

ggggttccgc gcacatttcc ccgaaaagtg ccacctgaaa ttgtaaacgt taatattttg     6960

ttaaaattcg cgttaaattt ttgttaaatc agctcatttt ttaaccaata ggccgaaatc     7020

ggcaaaatcc cttataaatc aaaagaatag accgagatag ggttgagtgt tgttccagtt     7080

tggaacaaga gtccactatt aaagaacgtg gactccaacg tcaaagggcg aaaaaccgtc     7140

tatcagggcg atggcccact acgtgaacca tcaccctaat caagtttttt ggggtcgagg     7200

tgccgtaaag cactaaatcg gaaccctaaa gggagccccc gatttagagc ttgacgggga     7260

aagccggcga acgtggcgag aaaggaaggg aagaaagcga aaggagcggg cgctagggcg     7320

ctggcaagtg tagcggtcac gctgcgcgta accaccacac ccgccgcgct taatgcgccg     7380

ctacagggcg cgtcccattc gcca                                            7404


<210>  51
<211>  7404
<212>  DNA
<213>  artificial

<220>
<223>  Vektor pFr7(DI)

<400>  51
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagtgcggcc gcaagcttct      180

agtcgcggta gaacgacccc atgtagcgga tgtactcgtc ctcggtgtgg tttgccttcc      240

agtcgtggac ggagtccttg ttgcgctggc cggcgatgac ggagagctcc ttacccagct      300

tctcaaaggc ctcgtcaacg cactcctcgg gggtgagggc gatcttcatg acggcctcgc      360

cctgcgggcc gccggggagg ttggacagca ggctgggggt tagggtggtg ccgagggtga      420

tgacctcgac gtcgacgccg gtgccctcgc actcgcaggc cacggcctcg gtcatcttga      480

ggatgaaggc cttgcccgcg ccgtactggc cgttccaggg gctggagctg atgccggtca      540

tcgacgagac gttgatcacg gcgccgcggt cctgggcggc aaagatccgc atgtagtggt      600

ggaagcactt gaggaaggtc acgacgttga cgttgatcat ggcctcgtgc ttctcccagg      660

gggtgtcctg gatcttaccg aagctgtgca ggcaggccac gtagctcatg aagcccatgt      720

ccaggccctc ggtcgcggcg aagacggtct cggcagcgcc gggctggcta aagtcggcgc      780

gcacgacctt ggtctccacg ccgtaggtct cgcggatctc gcctgcgagc acgttcagct      840

tctcctcgcg aatgtcgacc atgacgacgt tcatgccgcc ggcggcgatc ttctcgcaga      900

acgccttgcc gacgccctcg gtcgcgccca ggatcaggcc ccactcaccg tacttctccc      960

tcaggttcat gtatatctcc tttcacgaat tctcagccgc cttcttgaac ttggcggcct     1020

cttccgaacc gccggtggca ttgcccttcg agtaggaatg cgcgccggtg ccggcaagag     1080

cgccgccctg cacgatgagg tattcgtcgc ggatcggacg gccctcgaag aagcactcca     1140

ggatctcgcg ggtgcccgcc gcataacgcg cctgcgcggt cagcgtggtg ccggagatgt     1200

gcggggtcat gccgttatag ggcatcgtcc gccaggggtg gtccttcggc gccggctgcg     1260

ggaaccacac gtcgccggca tagccggcca gccggccgga ttcgagcgca cgtgccacgg     1320

catcgcggtc gcacagcttg ccgcgggcgg tgttgacgat gtaggcgcca cgcttgaaca     1380

gcttcagcgt ctcgtcattg atcatgtgct cggtttcggg gtgcagcggg cagttcagcg     1440

tcaccacgtc gcaaaccgga tacatgtcct cgcgggtcgc gtgccaggtg aggttgagct     1500

ccttctcgac cgattccggc aggcggtgac ggccggtgta gtgcaggtgc acgtcgaacg     1560

gcgccagacg gcgcagcacc gcgagaccga tgcggccggc ggccacggtg ccgacatgca     1620

tcgcctcgag gtcgtaggcg tgggagacgc agtcggcgat gttccagccg cccttccgcg     1680

cccattcgtg cgagggcaga tagttgcgca ccagcgacag gatcatcatc accacatgct     1740

cggcgacgct gatcgagttg cagtaggtga cttccgccac ggtgacgttg cggtcgatag     1800

ccgactgaag atcgacgtgg tcggaaccga tgccggcggt gagcgcgagc ttcaggttct     1860

tggccttggc gatgcgctcg ggcgtcagat aggccggcca gaagggctgg gagatgacga     1920

catccgcatc gaccagctcg cgctcgaaca ccgagtcggg gccgtccttg tcggaggtca     1980

cgaccagggt gtggccgttg gattcgagat attcgcgcag gccgagctcg ccggagacgg     2040

agccgagcaa ctgcccgggc gtgaagtcga tggccttcgg cgtcggcaag atctggccgc     2100

ccggatagtg gtcgatcttc ggaagatcgt cgcgggcata ggtcttcggg tagccgtcga     2160

ccggatcatc gtaaagaacg cacaggacct ttgccatcat atgtatatct ccttcttaaa     2220

gttaaacaaa attatttcta gaggggaatt gttatccgct cacaattccc ctatagtgag     2280

tcgtattaat ttcgcgggat cgagatctcg atcctctacg ccggacgcat cgtggccggc     2340

atcaccggcg ccacaggtgc ggttgctggc gcctatatcg ccgacatcac cgatggggaa     2400

gatcgggctc gccacttcgg gctcatgagc gcttgtttcg gcgtgggtat ggtggcaggc     2460

cccgtggccg ggggactgtt gggcgccatc tccttgcatg caccattcct tgcggcggcg     2520

gtgctcaacg gcctcaacct actactgggc tgcttcctaa tgcaggagtc gcataaggga     2580

gagcgtcgag atcccggaca ccatcgaatg gcgcaaaacc tttcgcggta tggcatgata     2640

gcgcccggaa gagagtcaat tcagggtggt gaatgtgaaa ccagtaacgt tatacgatgt     2700

cgcagagtat gccggtgtct cttatcagac cgtttcccgc gtggtgaacc aggccagcca     2760

cgtttctgcg aaaacgcggg aaaaagtgga agcggcgatg gcggagctga attacattcc     2820

caaccgcgtg gcacaacaac tggcgggcaa acagtcgttg ctgattggcg ttgccacctc     2880

cagtctggcc ctgcacgcgc cgtcgcaaat tgtcgcggcg attaaatctc gcgccgatca     2940

actgggtgcc agcgtggtgg tgtcgatggt agaacgaagc ggcgtcgaag cctgtaaagc     3000

ggcggtgcac aatcttctcg cgcaacgcgt cagtgggctg atcattaact atccgctgga     3060

tgaccaggat gccattgctg tggaagctgc ctgcactaat gttccggcgt tatttcttga     3120

tgtctctgac cagacaccca tcaacagtat tattttctcc catgaagacg gtacgcgact     3180

gggcgtggag catctggtcg cattgggtca ccagcaaatc gcgctgttag cgggcccatt     3240

aagttctgtc tcggcgcgtc tgcgtctggc tggctggcat aaatatctca ctcgcaatca     3300

aattcagccg atagcggaac gggaaggcga ctggagtgcc atgtccggtt ttcaacaaac     3360

catgcaaatg ctgaatgagg gcatcgttcc cactgcgatg ctggttgcca acgatcagat     3420

ggcgctgggc gcaatgcgcg ccattaccga gtccgggctg cgcgttggtg cggatatctc     3480

ggtagtggga tacgacgata ccgaagacag ctcatgttat atcccgccgt taaccaccat     3540

caaacaggat tttcgcctgc tggggcaaac cagcgtggac cgcttgctgc aactctctca     3600

gggccaggcg gtgaagggca atcagctgtt gcccgtctca ctggtgaaaa gaaaaaccac     3660

cctggcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct     3720

ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtaagtt     3780

agctcactca ttaggcaccg ggatctcgac cgatgccctt gagagccttc aacccagtca     3840

gctccttccg gtgggcgcgg ggcatgacta tcgtcgccgc acttatgact gtcttcttta     3900

tcatgcaact cgtaggacag gtgccggcag cgctctgggt cattttcggc gaggaccgct     3960

ttcgctggag cgcgacgatg atcggcctgt cgcttgcggt attcggaatc ttgcacgccc     4020

tcgctcaagc cttcgtcact ggtcccgcca ccaaacgttt cggcgagaag caggccatta     4080

tcgccggcat ggcggcccca cgggtgcgca tgatcgtgct cctgtcgttg aggacccggc     4140

taggctggcg gggttgcctt actggttagc agaatgaatc accgatacgc gagcgaacgt     4200

gaagcgactg ctgctgcaaa acgtctgcga cctgagcaac aacatgaatg gtcttcggtt     4260

tccgtgtttc gtaaagtctg gaaacgcgga agtcagcgcc ctgcaccatt atgttccgga     4320

tctgcatcgc aggatgctgc tggctaccct gtggaacacc tacatctgta ttaacgaagc     4380

gctggcattg accctgagtg atttttctct ggtcccgccg catccatacc gccagttgtt     4440

taccctcaca acgttccagt aaccgggcat gttcatcatc agtaacccgt atcgtgagca     4500

tcctctctcg tttcatcggt atcattaccc ccatgaacag aaatccccct tacacggagg     4560

catcagtgac caaacaggaa aaaaccgccc ttaacatggc ccgctttatc agaagccaga     4620

cattaacgct tctggagaaa ctcaacgagc tggacgcgga tgaacaggca gacatctgtg     4680

aatcgcttca cgaccacgct gatgagcttt accgcagctg cctcgcgcgt ttcggtgatg     4740

acggtgaaaa cctctgacac atgcagctcc cggagacggt cacagcttgt ctgtaagcgg     4800

atgccgggag cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg tgtcggggcg     4860

cagccatgac ccagtcacgt agcgatagcg gagtgtatac tggcttaact atgcggcatc     4920

agagcagatt gtactgagag tgcaccatat atgcggtgtg aaataccgca cagatgcgta     4980

aggagaaaat accgcatcag gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg     5040

gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca     5100

gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac     5160

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     5220

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     5280

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     5340

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat     5400

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     5460

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac     5520

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt     5580

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaaggac agtatttggt     5640

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc     5700

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga     5760

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac     5820

gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc     5880

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct     5940

gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca     6000

tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct     6060

ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca     6120

ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc     6180

atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg     6240

cgcaacgttg ttgccattgc tgcaggcatc gtggtgtcac gctcgtcgtt tggtatggct     6300

tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa     6360

aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta     6420

tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc     6480

ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg     6540

agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa     6600

gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg     6660

agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc     6720

accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg     6780

gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat     6840

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     6900

ggggttccgc gcacatttcc ccgaaaagtg ccacctgaaa ttgtaaacgt taatattttg     6960

ttaaaattcg cgttaaattt ttgttaaatc agctcatttt ttaaccaata ggccgaaatc     7020

ggcaaaatcc cttataaatc aaaagaatag accgagatag ggttgagtgt tgttccagtt     7080

tggaacaaga gtccactatt aaagaacgtg gactccaacg tcaaagggcg aaaaaccgtc     7140

tatcagggcg atggcccact acgtgaacca tcaccctaat caagtttttt ggggtcgagg     7200

tgccgtaaag cactaaatcg gaaccctaaa gggagccccc gatttagagc ttgacgggga     7260

aagccggcga acgtggcgag aaaggaaggg aagaaagcga aaggagcggg cgctagggcg     7320

ctggcaagtg tagcggtcac gctgcgcgta accaccacac ccgccgcgct taatgcgccg     7380

ctacagggcg cgtcccattc gcca                                            7404


<210>  52
<211>  7404
<212>  DNA
<213>  artificial

<220>
<223>  Vektor pFr7(DV)

<400>  52
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagtgcggcc gcaagcttct      180

agtcgcggta gaacgacccc atgtagcgga tgtactcgtc ctcggtgtgg tttgccttcc      240

agtcgtggac ggagtccttg ttgcgctggc cggcgatgac ggagagctcc ttacccagct      300

tctcaaaggc ctcgtcaacg cactcctcgg gggtgagggc gatcttcatg acggcctcgc      360

cctgcgggcc gccggggagg ttggacagca ggctgggggt tagggtggtg ccgagggtga      420

tgacctcgac gtcgacgccg gtgccctcgc actcgcaggc cacggcctcg gtcatcttga      480

ggatgaaggc cttgcccgcg ccgtactggc cgttccaggg gctggagctg atgccggtca      540

tcgacgagac gttgatcacg gcgccgcggt cctgggcggc aaagatccgc atgtagtggt      600

ggaagcactt gaggaaggtc acgacgttga cgttgatcat ggcctcgtgc ttctcccagg      660

gggtgtcctg gatcttaccg aagctgtgca ggcaggccac gtagctcatg aagcccatgt      720

ccaggccctc ggtcgcggcg aagacggtct cggcagcgcc gggctggcta aagtcggcgc      780

gcacgacctt ggtctccacg ccgtaggtct cgcggatctc gcctgcgagc acgttcagct      840

tctcctcgcg aacgtcgacc atgacgacgt tcatgccgcc ggcggcgatc ttctcgcaga      900

acgccttgcc gacgccctcg gtcgcgccca ggatcaggcc ccactcaccg tacttctccc      960

tcaggttcat gtatatctcc tttcacgaat tctcagccgc cttcttgaac ttggcggcct     1020

cttccgaacc gccggtggca ttgcccttcg agtaggaatg cgcgccggtg ccggcaagag     1080

cgccgccctg cacgatgagg tattcgtcgc ggatcggacg gccctcgaag aagcactcca     1140

ggatctcgcg ggtgcccgcc gcataacgcg cctgcgcggt cagcgtggtg ccggagatgt     1200

gcggggtcat gccgttatag ggcatcgtcc gccaggggtg gtccttcggc gccggctgcg     1260

ggaaccacac gtcgccggca tagccggcca gccggccgga ttcgagcgca cgtgccacgg     1320

catcgcggtc gcacagcttg ccgcgggcgg tgttgacgat gtaggcgcca cgcttgaaca     1380

gcttcagcgt ctcgtcattg atcatgtgct cggtttcggg gtgcagcggg cagttcagcg     1440

tcaccacgtc gcaaaccgga tacatgtcct cgcgggtcgc gtgccaggtg aggttgagct     1500

ccttctcgac cgattccggc aggcggtgac ggccggtgta gtgcaggtgc acgtcgaacg     1560

gcgccagacg gcgcagcacc gcgagaccga tgcggccggc ggccacggtg ccgacatgca     1620

tcgcctcgag gtcgtaggcg tgggagacgc agtcggcgat gttccagccg cccttccgcg     1680

cccattcgtg cgagggcaga tagttgcgca ccagcgacag gatcatcatc accacatgct     1740

cggcgacgct gatcgagttg cagtaggtga cttccgccac ggtgacgttg cggtcgatag     1800

ccgactgaag atcgacgtgg tcggaaccga tgccggcggt gagcgcgagc ttcaggttct     1860

tggccttggc gatgcgctcg ggcgtcagat aggccggcca gaagggctgg gagatgacga     1920

catccgcatc gaccagctcg cgctcgaaca ccgagtcggg gccgtccttg tcggaggtca     1980

cgaccagggt gtggccgttg gattcgagat attcgcgcag gccgagctcg ccggagacgg     2040

agccgagcaa ctgcccgggc gtgaagtcga tggccttcgg cgtcggcaag atctggccgc     2100

ccggatagtg gtcgatcttc ggaagatcgt cgcgggcata ggtcttcggg tagccgtcga     2160

ccggatcatc gtaaagaacg cacaggacct ttgccatcat atgtatatct ccttcttaaa     2220

gttaaacaaa attatttcta gaggggaatt gttatccgct cacaattccc ctatagtgag     2280

tcgtattaat ttcgcgggat cgagatctcg atcctctacg ccggacgcat cgtggccggc     2340

atcaccggcg ccacaggtgc ggttgctggc gcctatatcg ccgacatcac cgatggggaa     2400

gatcgggctc gccacttcgg gctcatgagc gcttgtttcg gcgtgggtat ggtggcaggc     2460

cccgtggccg ggggactgtt gggcgccatc tccttgcatg caccattcct tgcggcggcg     2520

gtgctcaacg gcctcaacct actactgggc tgcttcctaa tgcaggagtc gcataaggga     2580

gagcgtcgag atcccggaca ccatcgaatg gcgcaaaacc tttcgcggta tggcatgata     2640

gcgcccggaa gagagtcaat tcagggtggt gaatgtgaaa ccagtaacgt tatacgatgt     2700

cgcagagtat gccggtgtct cttatcagac cgtttcccgc gtggtgaacc aggccagcca     2760

cgtttctgcg aaaacgcggg aaaaagtgga agcggcgatg gcggagctga attacattcc     2820

caaccgcgtg gcacaacaac tggcgggcaa acagtcgttg ctgattggcg ttgccacctc     2880

cagtctggcc ctgcacgcgc cgtcgcaaat tgtcgcggcg attaaatctc gcgccgatca     2940

actgggtgcc agcgtggtgg tgtcgatggt agaacgaagc ggcgtcgaag cctgtaaagc     3000

ggcggtgcac aatcttctcg cgcaacgcgt cagtgggctg atcattaact atccgctgga     3060

tgaccaggat gccattgctg tggaagctgc ctgcactaat gttccggcgt tatttcttga     3120

tgtctctgac cagacaccca tcaacagtat tattttctcc catgaagacg gtacgcgact     3180

gggcgtggag catctggtcg cattgggtca ccagcaaatc gcgctgttag cgggcccatt     3240

aagttctgtc tcggcgcgtc tgcgtctggc tggctggcat aaatatctca ctcgcaatca     3300

aattcagccg atagcggaac gggaaggcga ctggagtgcc atgtccggtt ttcaacaaac     3360

catgcaaatg ctgaatgagg gcatcgttcc cactgcgatg ctggttgcca acgatcagat     3420

ggcgctgggc gcaatgcgcg ccattaccga gtccgggctg cgcgttggtg cggatatctc     3480

ggtagtggga tacgacgata ccgaagacag ctcatgttat atcccgccgt taaccaccat     3540

caaacaggat tttcgcctgc tggggcaaac cagcgtggac cgcttgctgc aactctctca     3600

gggccaggcg gtgaagggca atcagctgtt gcccgtctca ctggtgaaaa gaaaaaccac     3660

cctggcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct     3720

ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtaagtt     3780

agctcactca ttaggcaccg ggatctcgac cgatgccctt gagagccttc aacccagtca     3840

gctccttccg gtgggcgcgg ggcatgacta tcgtcgccgc acttatgact gtcttcttta     3900

tcatgcaact cgtaggacag gtgccggcag cgctctgggt cattttcggc gaggaccgct     3960

ttcgctggag cgcgacgatg atcggcctgt cgcttgcggt attcggaatc ttgcacgccc     4020

tcgctcaagc cttcgtcact ggtcccgcca ccaaacgttt cggcgagaag caggccatta     4080

tcgccggcat ggcggcccca cgggtgcgca tgatcgtgct cctgtcgttg aggacccggc     4140

taggctggcg gggttgcctt actggttagc agaatgaatc accgatacgc gagcgaacgt     4200

gaagcgactg ctgctgcaaa acgtctgcga cctgagcaac aacatgaatg gtcttcggtt     4260

tccgtgtttc gtaaagtctg gaaacgcgga agtcagcgcc ctgcaccatt atgttccgga     4320

tctgcatcgc aggatgctgc tggctaccct gtggaacacc tacatctgta ttaacgaagc     4380

gctggcattg accctgagtg atttttctct ggtcccgccg catccatacc gccagttgtt     4440

taccctcaca acgttccagt aaccgggcat gttcatcatc agtaacccgt atcgtgagca     4500

tcctctctcg tttcatcggt atcattaccc ccatgaacag aaatccccct tacacggagg     4560

catcagtgac caaacaggaa aaaaccgccc ttaacatggc ccgctttatc agaagccaga     4620

cattaacgct tctggagaaa ctcaacgagc tggacgcgga tgaacaggca gacatctgtg     4680

aatcgcttca cgaccacgct gatgagcttt accgcagctg cctcgcgcgt ttcggtgatg     4740

acggtgaaaa cctctgacac atgcagctcc cggagacggt cacagcttgt ctgtaagcgg     4800

atgccgggag cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg tgtcggggcg     4860

cagccatgac ccagtcacgt agcgatagcg gagtgtatac tggcttaact atgcggcatc     4920

agagcagatt gtactgagag tgcaccatat atgcggtgtg aaataccgca cagatgcgta     4980

aggagaaaat accgcatcag gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg     5040

gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca     5100

gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac     5160

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     5220

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     5280

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     5340

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat     5400

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     5460

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac     5520

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt     5580

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaaggac agtatttggt     5640

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc     5700

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga     5760

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac     5820

gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc     5880

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct     5940

gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca     6000

tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct     6060

ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca     6120

ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc     6180

atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg     6240

cgcaacgttg ttgccattgc tgcaggcatc gtggtgtcac gctcgtcgtt tggtatggct     6300

tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa     6360

aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta     6420

tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc     6480

ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg     6540

agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa     6600

gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg     6660

agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc     6720

accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg     6780

gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat     6840

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     6900

ggggttccgc gcacatttcc ccgaaaagtg ccacctgaaa ttgtaaacgt taatattttg     6960

ttaaaattcg cgttaaattt ttgttaaatc agctcatttt ttaaccaata ggccgaaatc     7020

ggcaaaatcc cttataaatc aaaagaatag accgagatag ggttgagtgt tgttccagtt     7080

tggaacaaga gtccactatt aaagaacgtg gactccaacg tcaaagggcg aaaaaccgtc     7140

tatcagggcg atggcccact acgtgaacca tcaccctaat caagtttttt ggggtcgagg     7200

tgccgtaaag cactaaatcg gaaccctaaa gggagccccc gatttagagc ttgacgggga     7260

aagccggcga acgtggcgag aaaggaaggg aagaaagcga aaggagcggg cgctagggcg     7320

ctggcaagtg tagcggtcac gctgcgcgta accaccacac ccgccgcgct taatgcgccg     7380

ctacagggcg cgtcccattc gcca                                            7404


<210>  53
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  PCR Primer "G39D for"

<400>  53
gtcgtcatgg tcgaccgtcg cgaggag                                           27


<210>  54
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  PCR Primer "G39D_rev"

<400>  54
ctcctcgcga cggtcgacca tgacgac                                           27


<210>  55
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  PCR Primer "G39D/R40I_for"

<400>  55
gtcatggtcg acattcgcga ggag                                              24


<210>  56
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  PCR Primer "G39D/R40I_rev"

<400>  56
ctcctcgcga atgtcgacca tgac                                              24


<210>  57
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  PCR Primer "R40D_for"

<400>  57
gtcatggtcg gcgatcgcga ggagaag                                           27


<210>  58
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  PCR Primer "R40D_rev"

<400>  58
cttctcctcg cgatcgccga ccatgac                                           27


<210>  59
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  PCR Primer "R40D/R41I_for"

<400>  59
gtcatggtcg gcgatatcga ggagaagctg                                        30


<210>  60
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  PCR Primer "R40D/R41I_rev"

<400>  60
cagcttctcc tcgatatcgc cgaccatgac                                        30


<210>  61
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  PCR Primer "DIN_for"

<400>  61
atggtcgaca ttaacgagga gaagctg                                           27


<210>  62
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  PCR Primer "DIN_rev"

<400>  62
cagcttctcc tcgttaatgt cgaccat                                           27


<210>  63
<211>  8321
<212>  DNA
<213>  artificial

<220>
<223>  Plasmid pFr3T7(D)

<400>  63
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagtgcggcc gcctagtcgc      180

ggtagaacga ccccatgtag cggatgtact cgtcctcggt gtggtttgcc ttccagtcgt      240

ggacggagtc cttgttgcgc tggccggcga tgacggagag ctccttaccc agcttctcaa      300

aggcctcgtc aacgcactcc tcgggggtga gggcgatctt catgacggcc tcgccctgcg      360

ggccgccggg gaggttggac agcaggctgg gggttagggt ggtgccgagg gtgatgacct      420

cgacgtcgac gccggtgccc tcgcactcgc aggccacggc ctcggtcatc ttgaggatga      480

aggccttgcc cgcgccgtac tggccgttcc aggggctgga gctgatgccg gtcatcgacg      540

agacgttgat cacggcgccg cggtcctggg cggcaaagat ccgcatgtag tggtggaagc      600

acttgaggaa ggtcacgacg ttgacgttga tcatggcctc gtgcttctcc cagggggtgt      660

cctggatctt accgaagctg tgcaggcagg ccacgtagct catgaagccc atgtccaggc      720

cctcggtcgc ggcgaagacg gtctcggcag cgccgggctg gctaaagtcg gcgcgcacga      780

ccttggtctc cacgccgtag gtctcgcgga tctcgcctgc gagcacgttc agcttctcct      840

cgcgacggtc gaccatgacg acgttcatgc cgccggcggc gatcttctcg cagaacgcct      900

tgccgacgcc ctcggtcgcg cccaggatca ggccccactc accgtacttc tccctcaggt      960

tcatatgtat atctccttct tatacttaac taatatacta agatggggaa ttgttatccg     1020

ctcacaattc ccctatagtg agtcgtatta atttcgatta tgcggccgtg tacaatacga     1080

ttactttctg ttcgacttaa gcattataag ctttcagaac tgtgtcgggc gcatcaccgc     1140

atcaatgccg ccatcaatga cgatctgcgc gccatgcaca tagcttgcgg ccgggctcat     1200

caaaaaggcg atgaccgacg ccatctcgga cggctcggca cggcggccca tgggaggaac     1260

gaacttggca atggattcgc catagcgcgg gtcctgcagg cccgcctgca gcaagggagt     1320

ctcggttgca ccgggggcga tggtgttcag gcgcacgcca gcctcgcccc aggcggcggc     1380

gcgtttgcgc acagccaccg tcaaagcatt cttgctgccc gcataggcca gatttccgcc     1440

ctgctctccc gcatgttcga caatggcgcg ggccttggct tcctcgccgg cttccagtgc     1500

cagcgccagt gggttcttgt caaaagccag atgcgcggaa gccacggacg agatgacgac     1560

ggctgcgggc tgatggcctt ttttcagcgc tggcaaaaag gcatccatca gctcggtcgc     1620

gccaaaataa ttgaccgaaa ccacattgcc aagcaccttg gtctgcggtc ccaggccggc     1680

gcacagcacc aggccgtcca tgcccttgct gcacttcgcc agtacatcgg caatcgcctg     1740

ctttcgacct tcggccgtcg agagatcggc aatcacttcc gcatcgcgta tatcgatgcc     1800

tacgatctgg tgaccggccg cctccaggac cttgcgcgta gccgcaccaa tgccggtggc     1860

gcagccgctt atcacgatga tggacatgta tatctccttt cacgaattct cagccgcctt     1920

cttgaacttg gcggcctctt ccgaaccgcc ggtggcattg cccttcgagt aggaatgcgc     1980

gccggtgccg gcaagagcgc cgccctgcac gatgaggtat tcgtcgcgga tcggacggcc     2040

ctcgaagaag cactccagga tctcgcgggt gcccgccgca taacgcgcct gcgcggtcag     2100

cgtggtgccg gagatgtgcg gggtcatgcc gttatagggc atcgtccgcc aggggtggtc     2160

cttcggcgcc ggctgcggga accacacgtc gccggcatag ccggccagcc ggccggattc     2220

gagcgcacgt gccacggcat cgcggtcgca cagcttgccg cgggcggtgt tgacgatgta     2280

ggcgccacgc ttgaacagct tcagcgtctc gtcattgatc atgtgctcgg tttcggggtg     2340

cagcgggcag ttcagcgtca ccacgtcgca aaccggatac atgtcctcgc gggtcgcgtg     2400

ccaggtgagg ttgagctcct tctcgaccga ttccggcagg cggtgacggt cggtgtagtg     2460

caggtgcacg tcgaacggcg ccagacggcg cagcaccgcg agaccgatgc ggccggcggc     2520

cacggtgccg acatgcatcg cctcgaggtc gtaggcgtgg gagacgcagt cggcgatgtt     2580

ccagccgccc ttccgcgccc attcgtgcga gggcagatag ttgcgcacca gcgacaggat     2640

catcatcacc acatgctcgg cgacgctgat cgagttgcag taggtgactt ccgccacggt     2700

gacgttgcgg tcgatagccg actgaagatc gacgtggtcg gaaccgatgc cggcggtgag     2760

cgcgagcttc aggttcttgg ccttggcgat gcgctcgggc gtcagatagg ccggccagaa     2820

gggctgggag atgacgacat ccgcatcgac cagctcgcgc tcgaacaccg agtcggggcc     2880

gtccttgtcg gaggtcacga ccagggtgtg gccgttggat tcgagatatt cgcgcaggcc     2940

gagctcgccg gagacggagc cgagcaactg cccgggcgtg aagtcgatgg ccttcggcgt     3000

cggcaagatc tggccgcccg gatagtggtc gatcttcgga agatcgtcgc gggcataggt     3060

cttcgggtag ccgtcgaccg gatcatcgta aagaacgcac aggacctttg ccatcatatg     3120

tatatctcct tcttaaagtt aaacaaaatt atttctagag gggaattgtt atccgctcac     3180

aattccccta tagtgagtcg tattaatttc gcgggatcga gatctcgatc ctctacgccg     3240

gacgcatcgt ggccggcatc accggcgcca caggtgcggt tgctggcgcc tatatcgccg     3300

acatcaccga tggggaagat cgggctcgcc acttcgggct catgagcgct tgtttcggcg     3360

tgggtatggt ggcaggcccc gtggccgggg gactgttggg cgccatctcc ttgcatgcac     3420

cattccttgc ggcggcggtg ctcaacggcc tcaacctact actgggctgc ttcctaatgc     3480

aggagtcgca taagggagag cgtcgagatc ccggacacca tcgaatggcg caaaaccttt     3540

cgcggtatgg catgatagcg cccggaagag agtcaattca gggtggtgaa tgtgaaacca     3600

gtaacgttat acgatgtcgc agagtatgcc ggtgtctctt atcagaccgt ttcccgcgtg     3660

gtgaaccagg ccagccacgt ttctgcgaaa acgcgggaaa aagtggaagc ggcgatggcg     3720

gagctgaatt acattcccaa ccgcgtggca caacaactgg cgggcaaaca gtcgttgctg     3780

attggcgttg ccacctccag tctggccctg cacgcgccgt cgcaaattgt cgcggcgatt     3840

aaatctcgcg ccgatcaact gggtgccagc gtggtggtgt cgatggtaga acgaagcggc     3900

gtcgaagcct gtaaagcggc ggtgcacaat cttctcgcgc aacgcgtcag tgggctgatc     3960

attaactatc cgctggatga ccaggatgcc attgctgtgg aagctgcctg cactaatgtt     4020

ccggcgttat ttcttgatgt ctctgaccag acacccatca acagtattat tttctcccat     4080

gaagacggta cgcgactggg cgtggagcat ctggtcgcat tgggtcacca gcaaatcgcg     4140

ctgttagcgg gcccattaag ttctgtctcg gcgcgtctgc gtctggctgg ctggcataaa     4200

tatctcactc gcaatcaaat tcagccgata gcggaacggg aaggcgactg gagtgccatg     4260

tccggttttc aacaaaccat gcaaatgctg aatgagggca tcgttcccac tgcgatgctg     4320

gttgccaacg atcagatggc gctgggcgca atgcgcgcca ttaccgagtc cgggctgcgc     4380

gttggtgcgg atatctcggt agtgggatac gacgataccg aagacagctc atgttatatc     4440

ccgccgttaa ccaccatcaa acaggatttt cgcctgctgg ggcaaaccag cgtggaccgc     4500

ttgctgcaac tctctcaggg ccaggcggtg aagggcaatc agctgttgcc cgtctcactg     4560

gtgaaaagaa aaaccaccct ggcgcccaat acgcaaaccg cctctccccg cgcgttggcc     4620

gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa     4680

cgcaattaat gtaagttagc tcactcatta ggcaccggga tctcgaccga tgcccttgag     4740

agccttcaac ccagtcagct ccttccggtg ggcgcggggc atgactatcg tcgccgcact     4800

tatgactgtc ttctttatca tgcaactcgt aggacaggtg ccggcagcgc tctgggtcat     4860

tttcggcgag gaccgctttc gctggagcgc gacgatgatc ggcctgtcgc ttgcggtatt     4920

cggaatcttg cacgccctcg ctcaagcctt cgtcactggt cccgccacca aacgtttcgg     4980

cgagaagcag gccattatcg ccggcatggc ggccccacgg gtgcgcatga tcgtgctcct     5040

gtcgttgagg acccggctag gctggcgggg ttgccttact ggttagcaga atgaatcacc     5100

gatacgcgag cgaacgtgaa gcgactgctg ctgcaaaacg tctgcgacct gagcaacaac     5160

atgaatggtc ttcggtttcc gtgtttcgta aagtctggaa acgcggaagt cagcgccctg     5220

caccattatg ttccggatct gcatcgcagg atgctgctgg ctaccctgtg gaacacctac     5280

atctgtatta acgaagcgct ggcattgacc ctgagtgatt tttctctggt cccgccgcat     5340

ccataccgcc agttgtttac cctcacaacg ttccagtaac cgggcatgtt catcatcagt     5400

aacccgtatc gtgagcatcc tctctcgttt catcggtatc attaccccca tgaacagaaa     5460

tcccccttac acggaggcat cagtgaccaa acaggaaaaa accgccctta acatggcccg     5520

ctttatcaga agccagacat taacgcttct ggagaaactc aacgagctgg acgcggatga     5580

acaggcagac atctgtgaat cgcttcacga ccacgctgat gagctttacc gcagctgcct     5640

cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg agacggtcac     5700

agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt cagcgggtgt     5760

tggcgggtgt cggggcgcag ccatgaccca gtcacgtagc gatagcggag tgtatactgg     5820

cttaactatg cggcatcaga gcagattgta ctgagagtgc accatatatg cggtgtgaaa     5880

taccgcacag atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca     5940

ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg     6000

taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc     6060

agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc     6120

cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac     6180

tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc     6240

tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata     6300

gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc     6360

acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca     6420

acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag     6480

cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta     6540

gaaggacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg     6600

gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc     6660

agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt     6720

ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa     6780

ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat     6840

atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga     6900

tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac     6960

gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg     7020

ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg     7080

caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt     7140

cgccagttaa tagtttgcgc aacgttgttg ccattgctgc aggcatcgtg gtgtcacgct     7200

cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat     7260

cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta     7320

agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca     7380

tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat     7440

agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat accgcgccac     7500

atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa     7560

ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt     7620

cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg     7680

caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat     7740

attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt     7800

agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca cctgaaattg     7860

taaacgttaa tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta     7920

accaataggc cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt     7980

tgagtgttgt tccagtttgg aacaagagtc cactattaaa gaacgtggac tccaacgtca     8040

aagggcgaaa aaccgtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa     8100

gttttttggg gtcgaggtgc cgtaaagcac taaatcggaa ccctaaaggg agcccccgat     8160

ttagagcttg acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag     8220

gagcgggcgc tagggcgctg gcaagtgtag cggtcacgct gcgcgtaacc accacacccg     8280

ccgcgcttaa tgcgccgcta cagggcgcgt cccattcgcc a                         8321


<210>  64
<211>  8190
<212>  DNA
<213>  artificial

<220>
<223>  pF(G)r7(A)r3

<400>  64
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagtgcggcc gctcagaact      180

gtgtcgggcg catcaccgca tcaatgccgc catcaatgac gatctgcgcg ccatgcacat      240

agcttgcggc cgggctcatc aaaaaggcga tgaccgacgc catctcggac ggctcggcac      300

ggcggcccat gggaggaacg aacttggcaa tggattcgcc atagcgcggg tcctgcaggc      360

ccgcctgcag caagggagtc tcggttgcac cgggggcgat ggtgttcagg cgcacgccag      420

cctcgcccca ggcggcggcg cgtttgcgca cagccaccgt caaagcattc ttgctgcccg      480

cataggccag atttccgccc tgctctcccg catgttcgac aatggcgcgg gccttggctt      540

cctcgccggc ttccagtgcc agcgccagtg ggttcttgtc aaaagccaga tgcgcggaag      600

ccacggacga gatgacgacg gctgcgggct gatggccttt tttcagcgct ggcaaaaagg      660

catccatcag ctcggtcgcg ccaaaataat tgaccgaaac cacattgcca agcaccttgg      720

tctgcggtcc caggccggcg cacagcacca ggccgtccat gcccttgctg cacttcgcca      780

gtacatcggc aatcgcctgc tttcgacctt cggccgtcga gagatcggca atcacttccg      840

catcgcgtat atcgatgcct acgatctggt gaccggccgc ctccaggacc ttgcgcgtag      900

cggcaccaat gccggtggcg cagccgctta tcacgatgat ggacatgtat atctccttaa      960

gcttctagtc gcggtagaac gaccccatgt agcggatgta ctcgtcctcg gtgtggtttg     1020

ccttccagtc gtggacggag tccttgttgc gctggccggc gatgacggag agctccttac     1080

ccagcttctc aaaggcctcg tcaacgcact cctcgggggt gagggcgatc ttcatgacgg     1140

cctcgccctg cgggccgccg gggaggttgg acagcaggct gggggttagg gtggtgccga     1200

gggtgatgac ctcgacgtcg acgccggtgc cctcgcactc gcaggccacg gcctcggtca     1260

tcttgaggat gaaggccttg cccgcgccgt actggccgtt ccaggggctg gagctgatgc     1320

cggtcatcga cgagacgttg atcacggcgc cgcggtcctg ggcggcaaag atccgcatgt     1380

agtggtggaa gcacttgagg aaggtcacga cgttgacgtt gatcatggcc tcgtgcttct     1440

cccagggggt gtcctggatc ttaccgaagc tgtgcaggca ggccacgtag ctcatgaagc     1500

ccatgtccag gccctcggtc gcggcgaaga cggtctcggc agcgccgggc tggctaaagt     1560

cggcgcgcac gaccttggtc tccacgccgt aggtctcgcg gatctcgcct gcgagcacgt     1620

tcagcttctc ctcgcgacgg gcgaccatga cgacgttcat gccgccggcg gcgatcttct     1680

cgcagaacgc cttgccgacg ccctcggtcg cgcccaggat caggccccac tcaccgtact     1740

tctccctcag gttcatgtat atctcctttc acgaattctc agccgccttc ttgaacttgg     1800

cggcctcttc cgaaccgccg gtggcattgc ccttcgagta ggaatgcgcg ccggtgccgg     1860

caagagcgcc gccctgcacg atgaggtatt cgtcgcggat cggacggccc tcgaagaagc     1920

actccaggat ctcgcgggtg cccgccgcat aacgcgcctg cgcggtcagc gtggtgccgg     1980

agatgtgcgg ggtcatgccg ttatagggca tcgtccgcca ggggtggtcc ttcggcgccg     2040

gctgcgggaa ccacacgtcg ccggcatagc cggccagccg gccggattcg agcgcacgtg     2100

ccacggcatc gcggtcgcac agcttgccgc gggcggtgtt gacgatgtag gcgccacgct     2160

tgaacagctt cagcgtctcg tcattgatca tgtgctcggt ttcggggtgc agcgggcagt     2220

tcagcgtcac cacgtcgcaa accggataca tgtcctcgcg ggtcgcgtgc caggtgaggt     2280

tgagctcctt ctcgaccgat tccggcaggc ggtgacggcc ggtgtagtgc aggtgcacgt     2340

cgaacggcgc cagacggcgc agcaccgcga gaccgatgcg gccggcggcc acggtgccga     2400

catgcatcgc ctcgaggtcg taggcgtggg agacgcagtc ggcgatgttc cagccgccct     2460

tccgcgccca ttcgtgcgag ggcagatagt tgcgcaccag cgacaggatc atcatcacca     2520

catgctcggc gacgctgatc gagttgcagt aggtgacttc cgccacggtg acgttgcggt     2580

cgatagccga ctgaagatcg acgtggtcgg aaccgatgcc ggcggtgagc gcgagcttca     2640

ggttcttggc cttggcgatg cgctcgggcg tcagataggc cggccagaag ggctgggaga     2700

tgacgacatc cgcatcgacc agctcgcgct cgaacaccga gtcggggccg tccttgtcgg     2760

aggtcacgac cagggtgtgg ccgttggatt cgagatattc gcgcaggccg agctcgccgg     2820

agacggagcc gagcaactgc ccgggcgtga agtcgatggc cttcggcgtc ggcaagatct     2880

ggccgcccgg atagtggtcg atcttcggaa gatcgtcgcg ggcataggtc ttcgggtagc     2940

cgtcgaccgg atcatcgtaa agaacgcaca ggacctttgc catcatatgt atatctcctt     3000

cttaaagtta aacaaaatta tttctagagg ggaattgtta tccgctcaca attcccctat     3060

agtgagtcgt attaatttcg cgggatcgag atctcgatcc tctacgccgg acgcatcgtg     3120

gccggcatca ccggcgccac aggtgcggtt gctggcgcct atatcgccga catcaccgat     3180

ggggaagatc gggctcgcca cttcgggctc atgagcgctt gtttcggcgt gggtatggtg     3240

gcaggccccg tggccggggg actgttgggc gccatctcct tgcatgcacc attccttgcg     3300

gcggcggtgc tcaacggcct caacctacta ctgggctgct tcctaatgca ggagtcgcat     3360

aagggagagc gtcgagatcc cggacaccat cgaatggcgc aaaacctttc gcggtatggc     3420

atgatagcgc ccggaagaga gtcaattcag ggtggtgaat gtgaaaccag taacgttata     3480

cgatgtcgca gagtatgccg gtgtctctta tcagaccgtt tcccgcgtgg tgaaccaggc     3540

cagccacgtt tctgcgaaaa cgcgggaaaa agtggaagcg gcgatggcgg agctgaatta     3600

cattcccaac cgcgtggcac aacaactggc gggcaaacag tcgttgctga ttggcgttgc     3660

cacctccagt ctggccctgc acgcgccgtc gcaaattgtc gcggcgatta aatctcgcgc     3720

cgatcaactg ggtgccagcg tggtggtgtc gatggtagaa cgaagcggcg tcgaagcctg     3780

taaagcggcg gtgcacaatc ttctcgcgca acgcgtcagt gggctgatca ttaactatcc     3840

gctggatgac caggatgcca ttgctgtgga agctgcctgc actaatgttc cggcgttatt     3900

tcttgatgtc tctgaccaga cacccatcaa cagtattatt ttctcccatg aagacggtac     3960

gcgactgggc gtggagcatc tggtcgcatt gggtcaccag caaatcgcgc tgttagcggg     4020

cccattaagt tctgtctcgg cgcgtctgcg tctggctggc tggcataaat atctcactcg     4080

caatcaaatt cagccgatag cggaacggga aggcgactgg agtgccatgt ccggttttca     4140

acaaaccatg caaatgctga atgagggcat cgttcccact gcgatgctgg ttgccaacga     4200

tcagatggcg ctgggcgcaa tgcgcgccat taccgagtcc gggctgcgcg ttggtgcgga     4260

tatctcggta gtgggatacg acgataccga agacagctca tgttatatcc cgccgttaac     4320

caccatcaaa caggattttc gcctgctggg gcaaaccagc gtggaccgct tgctgcaact     4380

ctctcagggc caggcggtga agggcaatca gctgttgccc gtctcactgg tgaaaagaaa     4440

aaccaccctg gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat     4500

gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg     4560

taagttagct cactcattag gcaccgggat ctcgaccgat gcccttgaga gccttcaacc     4620

cagtcagctc cttccggtgg gcgcggggca tgactatcgt cgccgcactt atgactgtct     4680

tctttatcat gcaactcgta ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg     4740

accgctttcg ctggagcgcg acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc     4800

acgccctcgc tcaagccttc gtcactggtc ccgccaccaa acgtttcggc gagaagcagg     4860

ccattatcgc cggcatggcg gccccacggg tgcgcatgat cgtgctcctg tcgttgagga     4920

cccggctagg ctggcggggt tgccttactg gttagcagaa tgaatcaccg atacgcgagc     4980

gaacgtgaag cgactgctgc tgcaaaacgt ctgcgacctg agcaacaaca tgaatggtct     5040

tcggtttccg tgtttcgtaa agtctggaaa cgcggaagtc agcgccctgc accattatgt     5100

tccggatctg catcgcagga tgctgctggc taccctgtgg aacacctaca tctgtattaa     5160

cgaagcgctg gcattgaccc tgagtgattt ttctctggtc ccgccgcatc cataccgcca     5220

gttgtttacc ctcacaacgt tccagtaacc gggcatgttc atcatcagta acccgtatcg     5280

tgagcatcct ctctcgtttc atcggtatca ttacccccat gaacagaaat cccccttaca     5340

cggaggcatc agtgaccaaa caggaaaaaa ccgcccttaa catggcccgc tttatcagaa     5400

gccagacatt aacgcttctg gagaaactca acgagctgga cgcggatgaa caggcagaca     5460

tctgtgaatc gcttcacgac cacgctgatg agctttaccg cagctgcctc gcgcgtttcg     5520

gtgatgacgg tgaaaacctc tgacacatgc agctcccgga gacggtcaca gcttgtctgt     5580

aagcggatgc cgggagcaga caagcccgtc agggcgcgtc agcgggtgtt ggcgggtgtc     5640

ggggcgcagc catgacccag tcacgtagcg atagcggagt gtatactggc ttaactatgc     5700

ggcatcagag cagattgtac tgagagtgca ccatatatgc ggtgtgaaat accgcacaga     5760

tgcgtaagga gaaaataccg catcaggcgc tcttccgctt cctcgctcac tgactcgctg     5820

cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta     5880

tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc     5940

aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag     6000

catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac     6060

caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc     6120

ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt     6180

aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc     6240

gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga     6300

cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta     6360

ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aaggacagta     6420

tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga     6480

tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg     6540

cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag     6600

tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc     6660

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact     6720

tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt     6780

cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta     6840

ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta     6900

tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc     6960

gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat     7020

agtttgcgca acgttgttgc cattgctgca ggcatcgtgg tgtcacgctc gtcgtttggt     7080

atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg     7140

tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca     7200

gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta     7260

agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg     7320

cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact     7380

ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg     7440

ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt     7500

actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga     7560

ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc     7620

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa     7680

caaatagggg ttccgcgcac atttccccga aaagtgccac ctgaaattgt aaacgttaat     7740

attttgttaa aattcgcgtt aaatttttgt taaatcagct cattttttaa ccaataggcc     7800

gaaatcggca aaatccctta taaatcaaaa gaatagaccg agatagggtt gagtgttgtt     7860

ccagtttgga acaagagtcc actattaaag aacgtggact ccaacgtcaa agggcgaaaa     7920

accgtctatc agggcgatgg cccactacgt gaaccatcac cctaatcaag ttttttgggg     7980

tcgaggtgcc gtaaagcact aaatcggaac cctaaaggga gcccccgatt tagagcttga     8040

cggggaaagc cggcgaacgt ggcgagaaag gaagggaaga aagcgaaagg agcgggcgct     8100

agggcgctgg caagtgtagc ggtcacgctg cgcgtaacca ccacacccgc cgcgcttaat     8160

gcgccgctac agggcgcgtc ccattcgcca                                      8190


<210>  65
<211>  8190
<212>  DNA
<213>  artificial

<220>
<223>  pF(G)r7(S)r3

<400>  65
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagtgcggcc gctcagaact      180

gtgtcgggcg catcaccgca tcaatgccgc catcaatgac gatctgcgcg ccatgcacat      240

agcttgcggc cgggctcatc aaaaaggcga tgaccgacgc catctcggac ggctcggcac      300

ggcggcccat gggaggaacg aacttggcaa tggattcgcc atagcgcggg tcctgcaggc      360

ccgcctgcag caagggagtc tcggttgcac cgggggcgat ggtgttcagg cgcacgccag      420

cctcgcccca ggcggcggcg cgtttgcgca cagccaccgt caaagcattc ttgctgcccg      480

cataggccag atttccgccc tgctctcccg catgttcgac aatggcgcgg gccttggctt      540

cctcgccggc ttccagtgcc agcgccagtg ggttcttgtc aaaagccaga tgcgcggaag      600

ccacggacga gatgacgacg gctgcgggct gatggccttt tttcagcgct ggcaaaaagg      660

catccatcag ctcggtcgcg ccaaaataat tgaccgaaac cacattgcca agcaccttgg      720

tctgcggtcc caggccggcg cacagcacca ggccgtccat gcccttgctg cacttcgcca      780

gtacatcggc aatcgcctgc tttcgacctt cggccgtcga gagatcggca atcacttccg      840

catcgcgtat atcgatgcct acgatctggt gaccggccgc ctccaggacc ttgcgcgtag      900

cggcaccaat gccggtggcg cagccgctta tcacgatgat ggacatgtat atctccttaa      960

gcttctagtc gcggtagaac gaccccatgt agcggatgta ctcgtcctcg gtgtggtttg     1020

ccttccagtc gtggacggag tccttgttgc gctggccggc gatgacggag agctccttac     1080

ccagcttctc aaaggcctcg tcaacgcact cctcgggggt gagggcgatc ttcatgacgg     1140

cctcgccctg cgggccgccg gggaggttgg acagcaggct gggggttagg gtggtgccga     1200

gggtgatgac ctcgacgtcg acgccggtgc cctcgcactc gcaggccacg gcctcggtca     1260

tcttgaggat gaaggccttg cccgcgccgt actggccgtt ccaggggctg gagctgatgc     1320

cggtcatcga cgagacgttg atcacggcgc cgcggtcctg ggcggcaaag atccgcatgt     1380

agtggtggaa gcacttgagg aaggtcacga cgttgacgtt gatcatggcc tcgtgcttct     1440

cccagggggt gtcctggatc ttaccgaagc tgtgcaggca ggccacgtag ctcatgaagc     1500

ccatgtccag gccctcggtc gcggcgaaga cggtctcggc agcgccgggc tggctaaagt     1560

cggcgcgcac gaccttggtc tccacgccgt aggtctcgcg gatctcgcct gcgagcacgt     1620

tcagcttctc ctcgcgacgg ctgaccatga cgacgttcat gccgccggcg gcgatcttct     1680

cgcagaacgc cttgccgacg ccctcggtcg cgcccaggat caggccccac tcaccgtact     1740

tctccctcag gttcatgtat atctcctttc acgaattctc agccgccttc ttgaacttgg     1800

cggcctcttc cgaaccgccg gtggcattgc ccttcgagta ggaatgcgcg ccggtgccgg     1860

caagagcgcc gccctgcacg atgaggtatt cgtcgcggat cggacggccc tcgaagaagc     1920

actccaggat ctcgcgggtg cccgccgcat aacgcgcctg cgcggtcagc gtggtgccgg     1980

agatgtgcgg ggtcatgccg ttatagggca tcgtccgcca ggggtggtcc ttcggcgccg     2040

gctgcgggaa ccacacgtcg ccggcatagc cggccagccg gccggattcg agcgcacgtg     2100

ccacggcatc gcggtcgcac agcttgccgc gggcggtgtt gacgatgtag gcgccacgct     2160

tgaacagctt cagcgtctcg tcattgatca tgtgctcggt ttcggggtgc agcgggcagt     2220

tcagcgtcac cacgtcgcaa accggataca tgtcctcgcg ggtcgcgtgc caggtgaggt     2280

tgagctcctt ctcgaccgat tccggcaggc ggtgacggcc ggtgtagtgc aggtgcacgt     2340

cgaacggcgc cagacggcgc agcaccgcga gaccgatgcg gccggcggcc acggtgccga     2400

catgcatcgc ctcgaggtcg taggcgtggg agacgcagtc ggcgatgttc cagccgccct     2460

tccgcgccca ttcgtgcgag ggcagatagt tgcgcaccag cgacaggatc atcatcacca     2520

catgctcggc gacgctgatc gagttgcagt aggtgacttc cgccacggtg acgttgcggt     2580

cgatagccga ctgaagatcg acgtggtcgg aaccgatgcc ggcggtgagc gcgagcttca     2640

ggttcttggc cttggcgatg cgctcgggcg tcagataggc cggccagaag ggctgggaga     2700

tgacgacatc cgcatcgacc agctcgcgct cgaacaccga gtcggggccg tccttgtcgg     2760

aggtcacgac cagggtgtgg ccgttggatt cgagatattc gcgcaggccg agctcgccgg     2820

agacggagcc gagcaactgc ccgggcgtga agtcgatggc cttcggcgtc ggcaagatct     2880

ggccgcccgg atagtggtcg atcttcggaa gatcgtcgcg ggcataggtc ttcgggtagc     2940

cgtcgaccgg atcatcgtaa agaacgcaca ggacctttgc catcatatgt atatctcctt     3000

cttaaagtta aacaaaatta tttctagagg ggaattgtta tccgctcaca attcccctat     3060

agtgagtcgt attaatttcg cgggatcgag atctcgatcc tctacgccgg acgcatcgtg     3120

gccggcatca ccggcgccac aggtgcggtt gctggcgcct atatcgccga catcaccgat     3180

ggggaagatc gggctcgcca cttcgggctc atgagcgctt gtttcggcgt gggtatggtg     3240

gcaggccccg tggccggggg actgttgggc gccatctcct tgcatgcacc attccttgcg     3300

gcggcggtgc tcaacggcct caacctacta ctgggctgct tcctaatgca ggagtcgcat     3360

aagggagagc gtcgagatcc cggacaccat cgaatggcgc aaaacctttc gcggtatggc     3420

atgatagcgc ccggaagaga gtcaattcag ggtggtgaat gtgaaaccag taacgttata     3480

cgatgtcgca gagtatgccg gtgtctctta tcagaccgtt tcccgcgtgg tgaaccaggc     3540

cagccacgtt tctgcgaaaa cgcgggaaaa agtggaagcg gcgatggcgg agctgaatta     3600

cattcccaac cgcgtggcac aacaactggc gggcaaacag tcgttgctga ttggcgttgc     3660

cacctccagt ctggccctgc acgcgccgtc gcaaattgtc gcggcgatta aatctcgcgc     3720

cgatcaactg ggtgccagcg tggtggtgtc gatggtagaa cgaagcggcg tcgaagcctg     3780

taaagcggcg gtgcacaatc ttctcgcgca acgcgtcagt gggctgatca ttaactatcc     3840

gctggatgac caggatgcca ttgctgtgga agctgcctgc actaatgttc cggcgttatt     3900

tcttgatgtc tctgaccaga cacccatcaa cagtattatt ttctcccatg aagacggtac     3960

gcgactgggc gtggagcatc tggtcgcatt gggtcaccag caaatcgcgc tgttagcggg     4020

cccattaagt tctgtctcgg cgcgtctgcg tctggctggc tggcataaat atctcactcg     4080

caatcaaatt cagccgatag cggaacggga aggcgactgg agtgccatgt ccggttttca     4140

acaaaccatg caaatgctga atgagggcat cgttcccact gcgatgctgg ttgccaacga     4200

tcagatggcg ctgggcgcaa tgcgcgccat taccgagtcc gggctgcgcg ttggtgcgga     4260

tatctcggta gtgggatacg acgataccga agacagctca tgttatatcc cgccgttaac     4320

caccatcaaa caggattttc gcctgctggg gcaaaccagc gtggaccgct tgctgcaact     4380

ctctcagggc caggcggtga agggcaatca gctgttgccc gtctcactgg tgaaaagaaa     4440

aaccaccctg gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat     4500

gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg     4560

taagttagct cactcattag gcaccgggat ctcgaccgat gcccttgaga gccttcaacc     4620

cagtcagctc cttccggtgg gcgcggggca tgactatcgt cgccgcactt atgactgtct     4680

tctttatcat gcaactcgta ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg     4740

accgctttcg ctggagcgcg acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc     4800

acgccctcgc tcaagccttc gtcactggtc ccgccaccaa acgtttcggc gagaagcagg     4860

ccattatcgc cggcatggcg gccccacggg tgcgcatgat cgtgctcctg tcgttgagga     4920

cccggctagg ctggcggggt tgccttactg gttagcagaa tgaatcaccg atacgcgagc     4980

gaacgtgaag cgactgctgc tgcaaaacgt ctgcgacctg agcaacaaca tgaatggtct     5040

tcggtttccg tgtttcgtaa agtctggaaa cgcggaagtc agcgccctgc accattatgt     5100

tccggatctg catcgcagga tgctgctggc taccctgtgg aacacctaca tctgtattaa     5160

cgaagcgctg gcattgaccc tgagtgattt ttctctggtc ccgccgcatc cataccgcca     5220

gttgtttacc ctcacaacgt tccagtaacc gggcatgttc atcatcagta acccgtatcg     5280

tgagcatcct ctctcgtttc atcggtatca ttacccccat gaacagaaat cccccttaca     5340

cggaggcatc agtgaccaaa caggaaaaaa ccgcccttaa catggcccgc tttatcagaa     5400

gccagacatt aacgcttctg gagaaactca acgagctgga cgcggatgaa caggcagaca     5460

tctgtgaatc gcttcacgac cacgctgatg agctttaccg cagctgcctc gcgcgtttcg     5520

gtgatgacgg tgaaaacctc tgacacatgc agctcccgga gacggtcaca gcttgtctgt     5580

aagcggatgc cgggagcaga caagcccgtc agggcgcgtc agcgggtgtt ggcgggtgtc     5640

ggggcgcagc catgacccag tcacgtagcg atagcggagt gtatactggc ttaactatgc     5700

ggcatcagag cagattgtac tgagagtgca ccatatatgc ggtgtgaaat accgcacaga     5760

tgcgtaagga gaaaataccg catcaggcgc tcttccgctt cctcgctcac tgactcgctg     5820

cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta     5880

tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc     5940

aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag     6000

catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac     6060

caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc     6120

ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt     6180

aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc     6240

gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga     6300

cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta     6360

ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aaggacagta     6420

tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga     6480

tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg     6540

cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag     6600

tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc     6660

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact     6720

tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt     6780

cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta     6840

ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta     6900

tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc     6960

gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat     7020

agtttgcgca acgttgttgc cattgctgca ggcatcgtgg tgtcacgctc gtcgtttggt     7080

atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg     7140

tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca     7200

gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta     7260

agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg     7320

cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact     7380

ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg     7440

ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt     7500

actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga     7560

ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc     7620

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa     7680

caaatagggg ttccgcgcac atttccccga aaagtgccac ctgaaattgt aaacgttaat     7740

attttgttaa aattcgcgtt aaatttttgt taaatcagct cattttttaa ccaataggcc     7800

gaaatcggca aaatccctta taaatcaaaa gaatagaccg agatagggtt gagtgttgtt     7860

ccagtttgga acaagagtcc actattaaag aacgtggact ccaacgtcaa agggcgaaaa     7920

accgtctatc agggcgatgg cccactacgt gaaccatcac cctaatcaag ttttttgggg     7980

tcgaggtgcc gtaaagcact aaatcggaac cctaaaggga gcccccgatt tagagcttga     8040

cggggaaagc cggcgaacgt ggcgagaaag gaagggaaga aagcgaaagg agcgggcgct     8100

agggcgctgg caagtgtagc ggtcacgctg cgcgtaacca ccacacccgc cgcgcttaat     8160

gcgccgctac agggcgcgtc ccattcgcca                                      8190


<210>  66
<211>  7910
<212>  DNA
<213>  artificial

<220>
<223>  p3T7(A)rG

<400>  66
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagttaaccg cggcctgcct      180

ggaatgaagg atattgtgtc ataccgccgt ccgcgaataa cgtgatgcct gtgacgtagc      240

tggcttcctt cgaagcaagc caggctgcta ctgcggcgat ctcctccggt tcgccgatat      300

atcccattgg aatcatgctt tctacatcag ctttctgttt agggtcagcg aatttttcag      360

cattgattgg cgtgttgatc gcacctggcc caatattatt gacgcgaatg cccttcggcg      420

cgtattccaa cgctaatgtt tctgtcatca gctttatccc gcctttactt gccgcatagt      480

ggacaaataa cggccaagga atcacttcgt gcacactgga catgttaatg acatttccct      540

tgatatcgtt ttctacgaaa tatttaatcg cttcacggct tcctaaaaag gcacccgtta      600

agttcgtgcc gatgacttta tcccaatcct tgagcggcat ttcgtgagat ggcacaggat      660

tttcaagacc ggcattatta atcataatat cgagtgtgcc gaactcctta attgccgttt      720

gcacgatatt ttttacatct tcctctttcg tgacatctcc ttggacgaca acagcttcac      780

cgcccgcctt gatgacctct tcttttacct cgttcggatc ttgtttatta ctataatagt      840

tgataaccac ttttgcctgc tccttgccga agcgaatggc catcgccttt ccgagccctg      900

aagcagctcc tgtaatagcg acgacttttc cttttaaatc cggatacatg tatatctcct      960

tgcggccgcc tagtcgcggt agaacgaccc catgtagcgg atgtactcgt cctcggtgtg     1020

gtttgccttc cagtcgtgga cggagtcctt gttgcgctgg ccggcgatga cggagagctc     1080

cttacccagc ttctcaaagg cctcgtcaac gcactcctcg ggggtgaggg cgatcttcat     1140

gacggcctcg ccctgcgggc cgccggggag gttggacagc aggctggggg ttagggtggt     1200

gccgagggtg atgacctcga cgtcgacgcc ggtgccctcg cactcgcagg ccacggcctc     1260

ggtcatcttg aggatgaagg ccttgcccgc gccgtactgg ccgttccagg ggctggagct     1320

gatgccggtc atcgacgaga cgttgatcac ggcgccgcgg tcctgggcgg caaagatccg     1380

catgtagtgg tggaagcact tgaggaaggt cacgacgttg acgttgatca tggcctcgtg     1440

cttctcccag ggggtgtcct ggatcttacc gaagctgtgc aggcaggcca cgtagctcat     1500

gaagcccatg tccaggccct cggtcgcggc gaagacggtc tcggcagcgc cgggctggct     1560

aaagtcggcg cgcacgacct tggtctccac gccgtaggtc tcgcggatct cgcctgcgag     1620

cacgttcagc ttctcctcgc gacgggcgac catgacgacg ttcatgccgc cggcggcgat     1680

cttctcgcag aacgccttgc cgacgccctc ggtcgcgccc aggatcaggc cccactcacc     1740

gtacttctcc ctcaggttca tatgtatatc tccttcttat acttaactaa tatactaaga     1800

tggggaattg ttatccgctc acaattcccc tatagtgagt cgtattaatt tcgattatgc     1860

ggccgtgtac aatacgatta ctttctgttc gacttaagca ttataagctt gtcgacggag     1920

ctcgaattct cagaactgtg tcgggcgcat caccgcatca atgccgccat caatgacgat     1980

ctgcgcgcca tgcacatagc ttgcggccgg gctcatcaaa aaggcgatga ccgacgccat     2040

ctcggacggc tcggcacggc ggcccatggg aggaacgaac ttggcaatgg attcgccata     2100

gcgcgggtcc tgcaggcccg cctgcagcaa gggagtctcg gttgcaccgg gggcgatggt     2160

gttcaggcgc acgccagcct cgccccaggc ggcggcgcgt ttgcgcacag ccaccgtcaa     2220

agcattcttg ctgcccgcat aggccagatt tccgccctgc tctcccgcat gttcgacaat     2280

ggcgcgggcc ttggcttcct cgccggcttc cagtgccagc gccagtgggt tcttgtcaaa     2340

agccagatgc gcggaagcca cggacgagat gacgacggct gcgggctgat ggcctttttt     2400

cagcgctggc aaaaaggcat ccatcagctc ggtcgcgcca aaataattga ccgaaaccac     2460

attgccaagc accttggtct gcggtcccag gccggcgcac agcaccaggc cgtccatgcc     2520

cttgctgcac ttcgccagta catcggcaat cgcctgcttt cgaccttcgg ccgtcgagag     2580

atcggcaatc acttccgcat cgcgtatatc gatgcctacg atctggtgac cggccgcctc     2640

caggaccttg cgcgtagccg caccaatgcc ggtggcgcag ccgcttatca cgatgatgga     2700

catcatatgt atatctcctt cttaaagtta aacaaaatta tttctagagg ggaattgtta     2760

tccgctcaca attcccctat agtgagtcgt attaatttcg cgggatcgag atctcgatcc     2820

tctacgccgg acgcatcgtg gccggcatca ccggcgccac aggtgcggtt gctggcgcct     2880

atatcgccga catcaccgat ggggaagatc gggctcgcca cttcgggctc atgagcgctt     2940

gtttcggcgt gggtatggtg gcaggccccg tggccggggg actgttgggc gccatctcct     3000

tgcatgcacc attccttgcg gcggcggtgc tcaacggcct caacctacta ctgggctgct     3060

tcctaatgca ggagtcgcat aagggagagc gtcgagatcc cggacaccat cgaatggcgc     3120

aaaacctttc gcggtatggc atgatagcgc ccggaagaga gtcaattcag ggtggtgaat     3180

gtgaaaccag taacgttata cgatgtcgca gagtatgccg gtgtctctta tcagaccgtt     3240

tcccgcgtgg tgaaccaggc cagccacgtt tctgcgaaaa cgcgggaaaa agtggaagcg     3300

gcgatggcgg agctgaatta cattcccaac cgcgtggcac aacaactggc gggcaaacag     3360

tcgttgctga ttggcgttgc cacctccagt ctggccctgc acgcgccgtc gcaaattgtc     3420

gcggcgatta aatctcgcgc cgatcaactg ggtgccagcg tggtggtgtc gatggtagaa     3480

cgaagcggcg tcgaagcctg taaagcggcg gtgcacaatc ttctcgcgca acgcgtcagt     3540

gggctgatca ttaactatcc gctggatgac caggatgcca ttgctgtgga agctgcctgc     3600

actaatgttc cggcgttatt tcttgatgtc tctgaccaga cacccatcaa cagtattatt     3660

ttctcccatg aagacggtac gcgactgggc gtggagcatc tggtcgcatt gggtcaccag     3720

caaatcgcgc tgttagcggg cccattaagt tctgtctcgg cgcgtctgcg tctggctggc     3780

tggcataaat atctcactcg caatcaaatt cagccgatag cggaacggga aggcgactgg     3840

agtgccatgt ccggttttca acaaaccatg caaatgctga atgagggcat cgttcccact     3900

gcgatgctgg ttgccaacga tcagatggcg ctgggcgcaa tgcgcgccat taccgagtcc     3960

gggctgcgcg ttggtgcgga tatctcggta gtgggatacg acgataccga agacagctca     4020

tgttatatcc cgccgttaac caccatcaaa caggattttc gcctgctggg gcaaaccagc     4080

gtggaccgct tgctgcaact ctctcagggc caggcggtga agggcaatca gctgttgccc     4140

gtctcactgg tgaaaagaaa aaccaccctg gcgcccaata cgcaaaccgc ctctccccgc     4200

gcgttggccg attcattaat gcagctggca cgacaggttt cccgactgga aagcgggcag     4260

tgagcgcaac gcaattaatg taagttagct cactcattag gcaccgggat ctcgaccgat     4320

gcccttgaga gccttcaacc cagtcagctc cttccggtgg gcgcggggca tgactatcgt     4380

cgccgcactt atgactgtct tctttatcat gcaactcgta ggacaggtgc cggcagcgct     4440

ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg acgatgatcg gcctgtcgct     4500

tgcggtattc ggaatcttgc acgccctcgc tcaagccttc gtcactggtc ccgccaccaa     4560

acgtttcggc gagaagcagg ccattatcgc cggcatggcg gccccacggg tgcgcatgat     4620

cgtgctcctg tcgttgagga cccggctagg ctggcggggt tgccttactg gttagcagaa     4680

tgaatcaccg atacgcgagc gaacgtgaag cgactgctgc tgcaaaacgt ctgcgacctg     4740

agcaacaaca tgaatggtct tcggtttccg tgtttcgtaa agtctggaaa cgcggaagtc     4800

agcgccctgc accattatgt tccggatctg catcgcagga tgctgctggc taccctgtgg     4860

aacacctaca tctgtattaa cgaagcgctg gcattgaccc tgagtgattt ttctctggtc     4920

ccgccgcatc cataccgcca gttgtttacc ctcacaacgt tccagtaacc gggcatgttc     4980

atcatcagta acccgtatcg tgagcatcct ctctcgtttc atcggtatca ttacccccat     5040

gaacagaaat cccccttaca cggaggcatc agtgaccaaa caggaaaaaa ccgcccttaa     5100

catggcccgc tttatcagaa gccagacatt aacgcttctg gagaaactca acgagctgga     5160

cgcggatgaa caggcagaca tctgtgaatc gcttcacgac cacgctgatg agctttaccg     5220

cagctgcctc gcgcgtttcg gtgatgacgg tgaaaacctc tgacacatgc agctcccgga     5280

gacggtcaca gcttgtctgt aagcggatgc cgggagcaga caagcccgtc agggcgcgtc     5340

agcgggtgtt ggcgggtgtc ggggcgcagc catgacccag tcacgtagcg atagcggagt     5400

gtatactggc ttaactatgc ggcatcagag cagattgtac tgagagtgca ccatatatgc     5460

ggtgtgaaat accgcacaga tgcgtaagga gaaaataccg catcaggcgc tcttccgctt     5520

cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact     5580

caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag     5640

caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata     5700

ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc     5760

cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg     5820

ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc     5880

tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg     5940

gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc     6000

ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga     6060

ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg     6120

gctacactag aaggacagta tttggtatct gcgctctgct gaagccagtt accttcggaa     6180

aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg     6240

tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt     6300

ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat     6360

tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct     6420

aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta     6480

tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc gtgtagataa     6540

ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac     6600

gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa     6660

gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag     6720

taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctgca ggcatcgtgg     6780

tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag     6840

ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg     6900

tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg cataattctc     6960

ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat     7020

tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata cgggataata     7080

ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa     7140

aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca     7200

actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc     7260

aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc     7320

tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg     7380

aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac     7440

ctgaaattgt aaacgttaat attttgttaa aattcgcgtt aaatttttgt taaatcagct     7500

cattttttaa ccaataggcc gaaatcggca aaatccctta taaatcaaaa gaatagaccg     7560

agatagggtt gagtgttgtt ccagtttgga acaagagtcc actattaaag aacgtggact     7620

ccaacgtcaa agggcgaaaa accgtctatc agggcgatgg cccactacgt gaaccatcac     7680

cctaatcaag ttttttgggg tcgaggtgcc gtaaagcact aaatcggaac cctaaaggga     7740

gcccccgatt tagagcttga cggggaaagc cggcgaacgt ggcgagaaag gaagggaaga     7800

aagcgaaagg agcgggcgct agggcgctgg caagtgtagc ggtcacgctg cgcgtaacca     7860

ccacacccgc cgcgcttaat gcgccgctac agggcgcgtc ccattcgcca                7910


<210>  67
<211>  7891
<212>  DNA
<213>  artificial

<220>
<223>  p7(A)T3rG

<400>  67
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagttaaccg cggcctgcct      180

ggaatgaagg atattgtgtc ataccgccgt ccgcgaataa cgtgatgcct gtgacgtagc      240

tggcttcctt cgaagcaagc caggctgcta ctgcggcgat ctcctccggt tcgccgatat      300

atcccattgg aatcatgctt tctacatcag ctttctgttt agggtcagcg aatttttcag      360

cattgattgg cgtgttgatc gcacctggcc caatattatt gacgcgaatg cccttcggcg      420

cgtattccaa cgctaatgtt tctgtcatca gctttatccc gcctttactt gccgcatagt      480

ggacaaataa cggccaagga atcacttcgt gcacactgga catgttaatg acatttccct      540

tgatatcgtt ttctacgaaa tatttaatcg cttcacggct tcctaaaaag gcacccgtta      600

agttcgtgcc gatgacttta tcccaatcct tgagcggcat ttcgtgagat ggcacaggat      660

tttcaagacc ggcattatta atcataatat cgagtgtgcc gaactcctta attgccgttt      720

gcacgatatt ttttacatct tcctctttcg tgacatctcc ttggacgaca acagcttcac      780

cgcccgcctt gatgacctct tcttttacct cgttcggatc ttgtttatta ctataatagt      840

tgataaccac ttttgcctgc tccttgccga agcgaatggc catcgccttt ccgagccctg      900

aagcagctcc tgtaatagcg acgacttttc cttttaaatc cggatacatg tatatctcct      960

tgcggccgct cagaactgtg tcgggcgcat caccgcatca atgccgccat caatgacgat     1020

ctgcgcgcca tgcacatagc ttgcggccgg gctcatcaaa aaggcgatga ccgacgccat     1080

ctcggacggc tcggcacggc ggcccatggg aggaacgaac ttggcaatgg attcgccata     1140

gcgcgggtcc tgcaggcccg cctgcagcaa gggagtctcg gttgcaccgg gggcgatggt     1200

gttcaggcgc acgccagcct cgccccaggc ggcggcgcgt ttgcgcacag ccaccgtcaa     1260

agcattcttg ctgcccgcat aggccagatt tccgccctgc tctcccgcat gttcgacaat     1320

ggcgcgggcc ttggcttcct cgccggcttc cagtgccagc gccagtgggt tcttgtcaaa     1380

agccagatgc gcggaagcca cggacgagat gacgacggct gcgggctgat ggcctttttt     1440

cagcgctggc aaaaaggcat ccatcagctc ggtcgcgcca aaataattga ccgaaaccac     1500

attgccaagc accttggtct gcggtcccag gccggcgcac agcaccaggc cgtccatgcc     1560

cttgctgcac ttcgccagta catcggcaat cgcctgcttt cgaccttcgg ccgtcgagag     1620

atcggcaatc acttccgcat cgcgtatatc gatgcctacg atctggtgac cggccgcctc     1680

caggaccttg cgcgtagcgg caccaatgcc ggtggcgcag ccgcttatca cgatgatgga     1740

catcatatgt atatctcctt cttatactta actaatatac taagatgggg aattgttatc     1800

cgctcacaat tcccctatag tgagtcgtat taatttcgat tatgcggccg tgtacaatac     1860

gattactttc tgttcgactt aagcattata agcttctagt cgcggtagaa cgaccccatg     1920

tagcggatgt actcgtcctc ggtgtggttt gccttccagt cgtggacgga gtccttgttg     1980

cgctggccgg cgatgacgga gagctcctta cccagcttct caaaggcctc gtcaacgcac     2040

tcctcggggg tgagggcgat cttcatgacg gcctcgccct gcgggccgcc ggggaggttg     2100

gacagcaggc tgggggttag ggtggtgccg agggtgatga cctcgacgtc gacgccggtg     2160

ccctcgcact cgcaggccac ggcctcggtc atcttgagga tgaaggcctt gcccgcgccg     2220

tactggccgt tccaggggct ggagctgatg ccggtcatcg acgagacgtt gatcacggcg     2280

ccgcggtcct gggcggcaaa gatccgcatg tagtggtgga agcacttgag gaaggtcacg     2340

acgttgacgt tgatcatggc ctcgtgcttc tcccaggggg tgtcctggat cttaccgaag     2400

ctgtgcaggc aggccacgta gctcatgaag cccatgtcca ggccctcggt cgcggcgaag     2460

acggtctcgg cagcgccggg ctggctaaag tcggcgcgca cgaccttggt ctccacgccg     2520

taggtctcgc ggatctcgcc tgcgagcacg ttcagcttct cctcgcgacg ggcgaccatg     2580

acgacgttca tgccgccggc ggcgatcttc tcgcagaacg ccttgccgac gccctcggtc     2640

gcgcccagga tcaggcccca ctcaccgtac ttctccctca ggttcatatg tatatctcct     2700

tcttaaagtt aaacaaaatt atttctagag gggaattgtt atccgctcac aattccccta     2760

tagtgagtcg tattaatttc gcgggatcga gatctcgatc ctctacgccg gacgcatcgt     2820

ggccggcatc accggcgcca caggtgcggt tgctggcgcc tatatcgccg acatcaccga     2880

tggggaagat cgggctcgcc acttcgggct catgagcgct tgtttcggcg tgggtatggt     2940

ggcaggcccc gtggccgggg gactgttggg cgccatctcc ttgcatgcac cattccttgc     3000

ggcggcggtg ctcaacggcc tcaacctact actgggctgc ttcctaatgc aggagtcgca     3060

taagggagag cgtcgagatc ccggacacca tcgaatggcg caaaaccttt cgcggtatgg     3120

catgatagcg cccggaagag agtcaattca gggtggtgaa tgtgaaacca gtaacgttat     3180

acgatgtcgc agagtatgcc ggtgtctctt atcagaccgt ttcccgcgtg gtgaaccagg     3240

ccagccacgt ttctgcgaaa acgcgggaaa aagtggaagc ggcgatggcg gagctgaatt     3300

acattcccaa ccgcgtggca caacaactgg cgggcaaaca gtcgttgctg attggcgttg     3360

ccacctccag tctggccctg cacgcgccgt cgcaaattgt cgcggcgatt aaatctcgcg     3420

ccgatcaact gggtgccagc gtggtggtgt cgatggtaga acgaagcggc gtcgaagcct     3480

gtaaagcggc ggtgcacaat cttctcgcgc aacgcgtcag tgggctgatc attaactatc     3540

cgctggatga ccaggatgcc attgctgtgg aagctgcctg cactaatgtt ccggcgttat     3600

ttcttgatgt ctctgaccag acacccatca acagtattat tttctcccat gaagacggta     3660

cgcgactggg cgtggagcat ctggtcgcat tgggtcacca gcaaatcgcg ctgttagcgg     3720

gcccattaag ttctgtctcg gcgcgtctgc gtctggctgg ctggcataaa tatctcactc     3780

gcaatcaaat tcagccgata gcggaacggg aaggcgactg gagtgccatg tccggttttc     3840

aacaaaccat gcaaatgctg aatgagggca tcgttcccac tgcgatgctg gttgccaacg     3900

atcagatggc gctgggcgca atgcgcgcca ttaccgagtc cgggctgcgc gttggtgcgg     3960

atatctcggt agtgggatac gacgataccg aagacagctc atgttatatc ccgccgttaa     4020

ccaccatcaa acaggatttt cgcctgctgg ggcaaaccag cgtggaccgc ttgctgcaac     4080

tctctcaggg ccaggcggtg aagggcaatc agctgttgcc cgtctcactg gtgaaaagaa     4140

aaaccaccct ggcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa     4200

tgcagctggc acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat     4260

gtaagttagc tcactcatta ggcaccggga tctcgaccga tgcccttgag agccttcaac     4320

ccagtcagct ccttccggtg ggcgcggggc atgactatcg tcgccgcact tatgactgtc     4380

ttctttatca tgcaactcgt aggacaggtg ccggcagcgc tctgggtcat tttcggcgag     4440

gaccgctttc gctggagcgc gacgatgatc ggcctgtcgc ttgcggtatt cggaatcttg     4500

cacgccctcg ctcaagcctt cgtcactggt cccgccacca aacgtttcgg cgagaagcag     4560

gccattatcg ccggcatggc ggccccacgg gtgcgcatga tcgtgctcct gtcgttgagg     4620

acccggctag gctggcgggg ttgccttact ggttagcaga atgaatcacc gatacgcgag     4680

cgaacgtgaa gcgactgctg ctgcaaaacg tctgcgacct gagcaacaac atgaatggtc     4740

ttcggtttcc gtgtttcgta aagtctggaa acgcggaagt cagcgccctg caccattatg     4800

ttccggatct gcatcgcagg atgctgctgg ctaccctgtg gaacacctac atctgtatta     4860

acgaagcgct ggcattgacc ctgagtgatt tttctctggt cccgccgcat ccataccgcc     4920

agttgtttac cctcacaacg ttccagtaac cgggcatgtt catcatcagt aacccgtatc     4980

gtgagcatcc tctctcgttt catcggtatc attaccccca tgaacagaaa tcccccttac     5040

acggaggcat cagtgaccaa acaggaaaaa accgccctta acatggcccg ctttatcaga     5100

agccagacat taacgcttct ggagaaactc aacgagctgg acgcggatga acaggcagac     5160

atctgtgaat cgcttcacga ccacgctgat gagctttacc gcagctgcct cgcgcgtttc     5220

ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg agacggtcac agcttgtctg     5280

taagcggatg ccgggagcag acaagcccgt cagggcgcgt cagcgggtgt tggcgggtgt     5340

cggggcgcag ccatgaccca gtcacgtagc gatagcggag tgtatactgg cttaactatg     5400

cggcatcaga gcagattgta ctgagagtgc accatatatg cggtgtgaaa taccgcacag     5460

atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct     5520

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     5580

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     5640

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5700

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5760

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5820

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5880

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5940

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     6000

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     6060

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt     6120

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     6180

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     6240

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     6300

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     6360

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     6420

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     6480

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     6540

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     6600

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6660

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6720

tagtttgcgc aacgttgttg ccattgctgc aggcatcgtg gtgtcacgct cgtcgtttgg     6780

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6840

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6900

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6960

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     7020

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat accgcgccac atagcagaac     7080

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     7140

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     7200

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     7260

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat attattgaag     7320

catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt agaaaaataa     7380

acaaataggg gttccgcgca catttccccg aaaagtgcca cctgaaattg taaacgttaa     7440

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta accaataggc     7500

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     7560

tccagtttgg aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     7620

aaccgtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     7680

gtcgaggtgc cgtaaagcac taaatcggaa ccctaaaggg agcccccgat ttagagcttg     7740

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggcgc     7800

tagggcgctg gcaagtgtag cggtcacgct gcgcgtaacc accacacccg ccgcgcttaa     7860

tgcgccgcta cagggcgcgt cccattcgcc a                                    7891


<210>  68
<211>  7404
<212>  DNA
<213>  artificial

<220>
<223>  pF(G)r7(A)

<400>  68
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagtgcggcc gcaagcttct      180

agtcgcggta gaacgacccc atgtagcgga tgtactcgtc ctcggtgtgg tttgccttcc      240

agtcgtggac ggagtccttg ttgcgctggc cggcgatgac ggagagctcc ttacccagct      300

tctcaaaggc ctcgtcaacg cactcctcgg gggtgagggc gatcttcatg acggcctcgc      360

cctgcgggcc gccggggagg ttggacagca ggctgggggt tagggtggtg ccgagggtga      420

tgacctcgac gtcgacgccg gtgccctcgc actcgcaggc cacggcctcg gtcatcttga      480

ggatgaaggc cttgcccgcg ccgtactggc cgttccaggg gctggagctg atgccggtca      540

tcgacgagac gttgatcacg gcgccgcggt cctgggcggc aaagatccgc atgtagtggt      600

ggaagcactt gaggaaggtc acgacgttga cgttgatcat ggcctcgtgc ttctcccagg      660

gggtgtcctg gatcttaccg aagctgtgca ggcaggccac gtagctcatg aagcccatgt      720

ccaggccctc ggtcgcggcg aagacggtct cggcagcgcc gggctggcta aagtcggcgc      780

gcacgacctt ggtctccacg ccgtaggtct cgcggatctc gcctgcgagc acgttcagct      840

tctcctcgcg acgggcgacc atgacgacgt tcatgccgcc ggcggcgatc ttctcgcaga      900

acgccttgcc gacgccctcg gtcgcgccca ggatcaggcc ccactcaccg tacttctccc      960

tcaggttcat gtatatctcc tttcacgaat tctcagccgc cttcttgaac ttggcggcct     1020

cttccgaacc gccggtggca ttgcccttcg agtaggaatg cgcgccggtg ccggcaagag     1080

cgccgccctg cacgatgagg tattcgtcgc ggatcggacg gccctcgaag aagcactcca     1140

ggatctcgcg ggtgcccgcc gcataacgcg cctgcgcggt cagcgtggtg ccggagatgt     1200

gcggggtcat gccgttatag ggcatcgtcc gccaggggtg gtccttcggc gccggctgcg     1260

ggaaccacac gtcgccggca tagccggcca gccggccgga ttcgagcgca cgtgccacgg     1320

catcgcggtc gcacagcttg ccgcgggcgg tgttgacgat gtaggcgcca cgcttgaaca     1380

gcttcagcgt ctcgtcattg atcatgtgct cggtttcggg gtgcagcggg cagttcagcg     1440

tcaccacgtc gcaaaccgga tacatgtcct cgcgggtcgc gtgccaggtg aggttgagct     1500

ccttctcgac cgattccggc aggcggtgac ggccggtgta gtgcaggtgc acgtcgaacg     1560

gcgccagacg gcgcagcacc gcgagaccga tgcggccggc ggccacggtg ccgacatgca     1620

tcgcctcgag gtcgtaggcg tgggagacgc agtcggcgat gttccagccg cccttccgcg     1680

cccattcgtg cgagggcaga tagttgcgca ccagcgacag gatcatcatc accacatgct     1740

cggcgacgct gatcgagttg cagtaggtga cttccgccac ggtgacgttg cggtcgatag     1800

ccgactgaag atcgacgtgg tcggaaccga tgccggcggt gagcgcgagc ttcaggttct     1860

tggccttggc gatgcgctcg ggcgtcagat aggccggcca gaagggctgg gagatgacga     1920

catccgcatc gaccagctcg cgctcgaaca ccgagtcggg gccgtccttg tcggaggtca     1980

cgaccagggt gtggccgttg gattcgagat attcgcgcag gccgagctcg ccggagacgg     2040

agccgagcaa ctgcccgggc gtgaagtcga tggccttcgg cgtcggcaag atctggccgc     2100

ccggatagtg gtcgatcttc ggaagatcgt cgcgggcata ggtcttcggg tagccgtcga     2160

ccggatcatc gtaaagaacg cacaggacct ttgccatcat atgtatatct ccttcttaaa     2220

gttaaacaaa attatttcta gaggggaatt gttatccgct cacaattccc ctatagtgag     2280

tcgtattaat ttcgcgggat cgagatctcg atcctctacg ccggacgcat cgtggccggc     2340

atcaccggcg ccacaggtgc ggttgctggc gcctatatcg ccgacatcac cgatggggaa     2400

gatcgggctc gccacttcgg gctcatgagc gcttgtttcg gcgtgggtat ggtggcaggc     2460

cccgtggccg ggggactgtt gggcgccatc tccttgcatg caccattcct tgcggcggcg     2520

gtgctcaacg gcctcaacct actactgggc tgcttcctaa tgcaggagtc gcataaggga     2580

gagcgtcgag atcccggaca ccatcgaatg gcgcaaaacc tttcgcggta tggcatgata     2640

gcgcccggaa gagagtcaat tcagggtggt gaatgtgaaa ccagtaacgt tatacgatgt     2700

cgcagagtat gccggtgtct cttatcagac cgtttcccgc gtggtgaacc aggccagcca     2760

cgtttctgcg aaaacgcggg aaaaagtgga agcggcgatg gcggagctga attacattcc     2820

caaccgcgtg gcacaacaac tggcgggcaa acagtcgttg ctgattggcg ttgccacctc     2880

cagtctggcc ctgcacgcgc cgtcgcaaat tgtcgcggcg attaaatctc gcgccgatca     2940

actgggtgcc agcgtggtgg tgtcgatggt agaacgaagc ggcgtcgaag cctgtaaagc     3000

ggcggtgcac aatcttctcg cgcaacgcgt cagtgggctg atcattaact atccgctgga     3060

tgaccaggat gccattgctg tggaagctgc ctgcactaat gttccggcgt tatttcttga     3120

tgtctctgac cagacaccca tcaacagtat tattttctcc catgaagacg gtacgcgact     3180

gggcgtggag catctggtcg cattgggtca ccagcaaatc gcgctgttag cgggcccatt     3240

aagttctgtc tcggcgcgtc tgcgtctggc tggctggcat aaatatctca ctcgcaatca     3300

aattcagccg atagcggaac gggaaggcga ctggagtgcc atgtccggtt ttcaacaaac     3360

catgcaaatg ctgaatgagg gcatcgttcc cactgcgatg ctggttgcca acgatcagat     3420

ggcgctgggc gcaatgcgcg ccattaccga gtccgggctg cgcgttggtg cggatatctc     3480

ggtagtggga tacgacgata ccgaagacag ctcatgttat atcccgccgt taaccaccat     3540

caaacaggat tttcgcctgc tggggcaaac cagcgtggac cgcttgctgc aactctctca     3600

gggccaggcg gtgaagggca atcagctgtt gcccgtctca ctggtgaaaa gaaaaaccac     3660

cctggcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct     3720

ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtaagtt     3780

agctcactca ttaggcaccg ggatctcgac cgatgccctt gagagccttc aacccagtca     3840

gctccttccg gtgggcgcgg ggcatgacta tcgtcgccgc acttatgact gtcttcttta     3900

tcatgcaact cgtaggacag gtgccggcag cgctctgggt cattttcggc gaggaccgct     3960

ttcgctggag cgcgacgatg atcggcctgt cgcttgcggt attcggaatc ttgcacgccc     4020

tcgctcaagc cttcgtcact ggtcccgcca ccaaacgttt cggcgagaag caggccatta     4080

tcgccggcat ggcggcccca cgggtgcgca tgatcgtgct cctgtcgttg aggacccggc     4140

taggctggcg gggttgcctt actggttagc agaatgaatc accgatacgc gagcgaacgt     4200

gaagcgactg ctgctgcaaa acgtctgcga cctgagcaac aacatgaatg gtcttcggtt     4260

tccgtgtttc gtaaagtctg gaaacgcgga agtcagcgcc ctgcaccatt atgttccgga     4320

tctgcatcgc aggatgctgc tggctaccct gtggaacacc tacatctgta ttaacgaagc     4380

gctggcattg accctgagtg atttttctct ggtcccgccg catccatacc gccagttgtt     4440

taccctcaca acgttccagt aaccgggcat gttcatcatc agtaacccgt atcgtgagca     4500

tcctctctcg tttcatcggt atcattaccc ccatgaacag aaatccccct tacacggagg     4560

catcagtgac caaacaggaa aaaaccgccc ttaacatggc ccgctttatc agaagccaga     4620

cattaacgct tctggagaaa ctcaacgagc tggacgcgga tgaacaggca gacatctgtg     4680

aatcgcttca cgaccacgct gatgagcttt accgcagctg cctcgcgcgt ttcggtgatg     4740

acggtgaaaa cctctgacac atgcagctcc cggagacggt cacagcttgt ctgtaagcgg     4800

atgccgggag cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg tgtcggggcg     4860

cagccatgac ccagtcacgt agcgatagcg gagtgtatac tggcttaact atgcggcatc     4920

agagcagatt gtactgagag tgcaccatat atgcggtgtg aaataccgca cagatgcgta     4980

aggagaaaat accgcatcag gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg     5040

gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca     5100

gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac     5160

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     5220

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     5280

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     5340

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat     5400

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     5460

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac     5520

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt     5580

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaaggac agtatttggt     5640

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc     5700

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga     5760

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac     5820

gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc     5880

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct     5940

gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca     6000

tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct     6060

ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca     6120

ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc     6180

atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg     6240

cgcaacgttg ttgccattgc tgcaggcatc gtggtgtcac gctcgtcgtt tggtatggct     6300

tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa     6360

aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta     6420

tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc     6480

ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg     6540

agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa     6600

gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg     6660

agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc     6720

accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg     6780

gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat     6840

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     6900

ggggttccgc gcacatttcc ccgaaaagtg ccacctgaaa ttgtaaacgt taatattttg     6960

ttaaaattcg cgttaaattt ttgttaaatc agctcatttt ttaaccaata ggccgaaatc     7020

ggcaaaatcc cttataaatc aaaagaatag accgagatag ggttgagtgt tgttccagtt     7080

tggaacaaga gtccactatt aaagaacgtg gactccaacg tcaaagggcg aaaaaccgtc     7140

tatcagggcg atggcccact acgtgaacca tcaccctaat caagtttttt ggggtcgagg     7200

tgccgtaaag cactaaatcg gaaccctaaa gggagccccc gatttagagc ttgacgggga     7260

aagccggcga acgtggcgag aaaggaaggg aagaaagcga aaggagcggg cgctagggcg     7320

ctggcaagtg tagcggtcac gctgcgcgta accaccacac ccgccgcgct taatgcgccg     7380

ctacagggcg cgtcccattc gcca                                            7404


<210>  69
<211>  7386
<212>  DNA
<213>  artificial

<220>
<223>  pFr3

<400>  69
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagtgcggcc gcaagctttc      180

agaactgtgt cgggcgcatc accgcatcaa tgccgccatc aatgacgatc tgcgcgccat      240

gcacatagct tgcggccggg ctcatcaaaa aggcgatgac cgacgccatc tcggacggct      300

cggcacggcg gcccatggga ggaacgaact tggcaatgga ttcgccatag cgcgggtcct      360

gcaggcccgc ctgcagcaag ggagtctcgg ttgcaccggg ggcgatggtg ttcaggcgca      420

cgccagcctc gccccaggcg gcggcgcgtt tgcgcacagc caccgtcaaa gcattcttgc      480

tgcccgcata ggccagattt ccgccctgct ctcccgcatg ttcgacaatg gcgcgggcct      540

tggcttcctc gccggcttcc agtgccagcg ccagtgggtt cttgtcaaaa gccagatgcg      600

cggaagccac ggacgagatg acgacggctg cgggctgatg gccttttttc agcgctggca      660

aaaaggcatc catcagctcg gtcgcgccaa aataattgac cgaaaccaca ttgccaagca      720

ccttggtctg cggtcccagg ccggcgcaca gcaccaggcc gtccatgccc ttgctgcact      780

tcgccagtac atcggcaatc gcctgctttc gaccttcggc cgtcgagaga tcggcaatca      840

cttccgcatc gcgtatatcg atgcctacga tctggtgacc ggccgcctcc aggaccttgc      900

gcgtagccgc accaatgccg gtggcgcagc cgcttatcac gatgatggac atgtatatct      960

cctttcacga attctcagcc gccttcttga acttggcggc ctcttccgaa ccgccggtgg     1020

cattgccctt cgagtaggaa tgcgcgccgg tgccggcaag agcgccgccc tgcacgatga     1080

ggtattcgtc gcggatcgga cggccctcga agaagcactc caggatctcg cgggtgcccg     1140

ccgcataacg cgcctgcgcg gtcagcgtgg tgccggagat gtgcggggtc atgccgttat     1200

agggcatcgt ccgccagggg tggtccttcg gcgccggctg cgggaaccac acgtcgccgg     1260

catagccggc cagccggccg gattcgagcg cacgtgccac ggcatcgcgg tcgcacagct     1320

tgccgcgggc ggtgttgacg atgtaggcgc cacgcttgaa cagcttcagc gtctcgtcat     1380

tgatcatgtg ctcggtttcg gggtgcagcg ggcagttcag cgtcaccacg tcgcaaaccg     1440

gatacatgtc ctcgcgggtc gcgtgccagg tgaggttgag ctccttctcg accgattccg     1500

gcaggcggtg acggtcggtg tagtgcaggt gcacgtcgaa cggcgccaga cggcgcagca     1560

ccgcgagacc gatgcggccg gcggccacgg tgccgacatg catcgcctcg aggtcgtagg     1620

cgtgggagac gcagtcggcg atgttccagc cgcccttccg cgcccattcg tgcgagggca     1680

gatagttgcg caccagcgac aggatcatca tcaccacatg ctcggcgacg ctgatcgagt     1740

tgcagtaggt gacttccgcc acggtgacgt tgcggtcgat agccgactga agatcgacgt     1800

ggtcggaacc gatgccggcg gtgagcgcga gcttcaggtt cttggccttg gcgatgcgct     1860

cgggcgtcag ataggccggc cagaagggct gggagatgac gacatccgca tcgaccagct     1920

cgcgctcgaa caccgagtcg gggccgtcct tgtcggaggt cacgaccagg gtgtggccgt     1980

tggattcgag atattcgcgc aggccgagct cgccggagac ggagccgagc aactgcccgg     2040

gcgtgaagtc gatggccttc ggcgtcggca agatctggcc gcccggatag tggtcgatct     2100

tcggaagatc gtcgcgggca taggtcttcg ggtagccgtc gaccggatca tcgtaaagaa     2160

cgcacaggac ctttgccatc atatgtatat ctccttctta aagttaaaca aaattatttc     2220

tagaggggaa ttgttatccg ctcacaattc ccctatagtg agtcgtatta atttcgcggg     2280

atcgagatct cgatcctcta cgccggacgc atcgtggccg gcatcaccgg cgccacaggt     2340

gcggttgctg gcgcctatat cgccgacatc accgatgggg aagatcgggc tcgccacttc     2400

gggctcatga gcgcttgttt cggcgtgggt atggtggcag gccccgtggc cgggggactg     2460

ttgggcgcca tctccttgca tgcaccattc cttgcggcgg cggtgctcaa cggcctcaac     2520

ctactactgg gctgcttcct aatgcaggag tcgcataagg gagagcgtcg agatcccgga     2580

caccatcgaa tggcgcaaaa cctttcgcgg tatggcatga tagcgcccgg aagagagtca     2640

attcagggtg gtgaatgtga aaccagtaac gttatacgat gtcgcagagt atgccggtgt     2700

ctcttatcag accgtttccc gcgtggtgaa ccaggccagc cacgtttctg cgaaaacgcg     2760

ggaaaaagtg gaagcggcga tggcggagct gaattacatt cccaaccgcg tggcacaaca     2820

actggcgggc aaacagtcgt tgctgattgg cgttgccacc tccagtctgg ccctgcacgc     2880

gccgtcgcaa attgtcgcgg cgattaaatc tcgcgccgat caactgggtg ccagcgtggt     2940

ggtgtcgatg gtagaacgaa gcggcgtcga agcctgtaaa gcggcggtgc acaatcttct     3000

cgcgcaacgc gtcagtgggc tgatcattaa ctatccgctg gatgaccagg atgccattgc     3060

tgtggaagct gcctgcacta atgttccggc gttatttctt gatgtctctg accagacacc     3120

catcaacagt attattttct cccatgaaga cggtacgcga ctgggcgtgg agcatctggt     3180

cgcattgggt caccagcaaa tcgcgctgtt agcgggccca ttaagttctg tctcggcgcg     3240

tctgcgtctg gctggctggc ataaatatct cactcgcaat caaattcagc cgatagcgga     3300

acgggaaggc gactggagtg ccatgtccgg ttttcaacaa accatgcaaa tgctgaatga     3360

gggcatcgtt cccactgcga tgctggttgc caacgatcag atggcgctgg gcgcaatgcg     3420

cgccattacc gagtccgggc tgcgcgttgg tgcggatatc tcggtagtgg gatacgacga     3480

taccgaagac agctcatgtt atatcccgcc gttaaccacc atcaaacagg attttcgcct     3540

gctggggcaa accagcgtgg accgcttgct gcaactctct cagggccagg cggtgaaggg     3600

caatcagctg ttgcccgtct cactggtgaa aagaaaaacc accctggcgc ccaatacgca     3660

aaccgcctct ccccgcgcgt tggccgattc attaatgcag ctggcacgac aggtttcccg     3720

actggaaagc gggcagtgag cgcaacgcaa ttaatgtaag ttagctcact cattaggcac     3780

cgggatctcg accgatgccc ttgagagcct tcaacccagt cagctccttc cggtgggcgc     3840

ggggcatgac tatcgtcgcc gcacttatga ctgtcttctt tatcatgcaa ctcgtaggac     3900

aggtgccggc agcgctctgg gtcattttcg gcgaggaccg ctttcgctgg agcgcgacga     3960

tgatcggcct gtcgcttgcg gtattcggaa tcttgcacgc cctcgctcaa gccttcgtca     4020

ctggtcccgc caccaaacgt ttcggcgaga agcaggccat tatcgccggc atggcggccc     4080

cacgggtgcg catgatcgtg ctcctgtcgt tgaggacccg gctaggctgg cggggttgcc     4140

ttactggtta gcagaatgaa tcaccgatac gcgagcgaac gtgaagcgac tgctgctgca     4200

aaacgtctgc gacctgagca acaacatgaa tggtcttcgg tttccgtgtt tcgtaaagtc     4260

tggaaacgcg gaagtcagcg ccctgcacca ttatgttccg gatctgcatc gcaggatgct     4320

gctggctacc ctgtggaaca cctacatctg tattaacgaa gcgctggcat tgaccctgag     4380

tgatttttct ctggtcccgc cgcatccata ccgccagttg tttaccctca caacgttcca     4440

gtaaccgggc atgttcatca tcagtaaccc gtatcgtgag catcctctct cgtttcatcg     4500

gtatcattac ccccatgaac agaaatcccc cttacacgga ggcatcagtg accaaacagg     4560

aaaaaaccgc ccttaacatg gcccgcttta tcagaagcca gacattaacg cttctggaga     4620

aactcaacga gctggacgcg gatgaacagg cagacatctg tgaatcgctt cacgaccacg     4680

ctgatgagct ttaccgcagc tgcctcgcgc gtttcggtga tgacggtgaa aacctctgac     4740

acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg agcagacaag     4800

cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg cgcagccatg acccagtcac     4860

gtagcgatag cggagtgtat actggcttaa ctatgcggca tcagagcaga ttgtactgag     4920

agtgcaccat atatgcggtg tgaaataccg cacagatgcg taaggagaaa ataccgcatc     4980

aggcgctctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga     5040

gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca     5100

ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg     5160

ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt     5220

cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc     5280

ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct     5340

tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc     5400

gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta     5460

tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca     5520

gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag     5580

tggtggccta actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag     5640

ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt     5700

agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa     5760

gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg     5820

attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga     5880

agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta     5940

atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc     6000

cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg     6060

ataccgcgag acccacgctc accggctcca gatttatcag caataaacca gccagccgga     6120

agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt     6180

tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt     6240

gctgcaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc     6300

caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc     6360

ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca     6420

gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag     6480

tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg     6540

tcaatacggg ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa     6600

cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa     6660

cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga     6720

gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga     6780

atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg     6840

agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt     6900

ccccgaaaag tgccacctga aattgtaaac gttaatattt tgttaaaatt cgcgttaaat     6960

ttttgttaaa tcagctcatt ttttaaccaa taggccgaaa tcggcaaaat cccttataaa     7020

tcaaaagaat agaccgagat agggttgagt gttgttccag tttggaacaa gagtccacta     7080

ttaaagaacg tggactccaa cgtcaaaggg cgaaaaaccg tctatcaggg cgatggccca     7140

ctacgtgaac catcacccta atcaagtttt ttggggtcga ggtgccgtaa agcactaaat     7200

cggaacccta aagggagccc ccgatttaga gcttgacggg gaaagccggc gaacgtggcg     7260

agaaaggaag ggaagaaagc gaaaggagcg ggcgctaggg cgctggcaag tgtagcggtc     7320

acgctgcgcg taaccaccac acccgccgcg cttaatgcgc cgctacaggg cgcgtcccat     7380

tcgcca                                                                7386


