                         SEQUENCE LISTING

<110>  Universitt Goettingen
 
<120>  MHC Genes and risk of graft versus host disease

<130>  30A-116821

<160>  77    

<170>  PatentIn version 3.5

<210>  1
<211>  4100
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (134)..(1129)
<223>  Ctss

<400>  1
gtacctcatg tgacaagttc caatttcttt tcaagtcaat tgaactgaaa tctccttgtt       60

gctttgaaat cttagaagag agcccactaa ttcaaggact cttactgtgg gagcaactgc      120

tggttctatc aca atg aaa cgg ctg gtt tgt gtg ctc ttg gtg tgc tcc         169
               Met Lys Arg Leu Val Cys Val Leu Leu Val Cys Ser            
               1               5                   10                     

tct gca gtg gca cag ttg cat aaa gat cct acc ctg gat cac cac tgg        217
Ser Ala Val Ala Gln Leu His Lys Asp Pro Thr Leu Asp His His Trp           
        15                  20                  25                        

cat ctc tgg aag aaa acc tat ggc aaa caa tac aag gaa aag aat gaa        265
His Leu Trp Lys Lys Thr Tyr Gly Lys Gln Tyr Lys Glu Lys Asn Glu           
    30                  35                  40                            

gaa gca gta cga cgt ctc atc tgg gaa aag aat cta aag ttt gtg atg        313
Glu Ala Val Arg Arg Leu Ile Trp Glu Lys Asn Leu Lys Phe Val Met           
45                  50                  55                  60            

ctt cac aac ctg gag cat tca atg gga atg cac tca tac gat ctg ggc        361
Leu His Asn Leu Glu His Ser Met Gly Met His Ser Tyr Asp Leu Gly           
                65                  70                  75                

atg aac cac ctg gga gac atg acc agt gaa gaa gtg atg tct ttg atg        409
Met Asn His Leu Gly Asp Met Thr Ser Glu Glu Val Met Ser Leu Met           
            80                  85                  90                    

agt tcc ctg aga gtt ccc agc cag tgg cag aga aat atc aca tat aag        457
Ser Ser Leu Arg Val Pro Ser Gln Trp Gln Arg Asn Ile Thr Tyr Lys           
        95                  100                 105                       

tca aac cct aat cgg ata ttg cct gat tct gtg gac tgg aga gag aaa        505
Ser Asn Pro Asn Arg Ile Leu Pro Asp Ser Val Asp Trp Arg Glu Lys           
    110                 115                 120                           

ggg tgt gtt act gaa gtg aaa tat caa ggt tct tgt ggt gct tgc tgg        553
Gly Cys Val Thr Glu Val Lys Tyr Gln Gly Ser Cys Gly Ala Cys Trp           
125                 130                 135                 140           

gct ttc agt gct gtg ggg gcc ctg gaa gca cag ctg aag ctg aaa aca        601
Ala Phe Ser Ala Val Gly Ala Leu Glu Ala Gln Leu Lys Leu Lys Thr           
                145                 150                 155               

gga aag ctg gtg tct ctc agt gcc cag aac ctg gtg gat tgc tca act        649
Gly Lys Leu Val Ser Leu Ser Ala Gln Asn Leu Val Asp Cys Ser Thr           
            160                 165                 170                   

gaa aaa tat gga aac aaa ggc tgc aat ggt ggc ttc atg aca acg gct        697
Glu Lys Tyr Gly Asn Lys Gly Cys Asn Gly Gly Phe Met Thr Thr Ala           
        175                 180                 185                       

ttc cag tac atc att gat aac aag ggc atc gac tca gac gct tcc tat        745
Phe Gln Tyr Ile Ile Asp Asn Lys Gly Ile Asp Ser Asp Ala Ser Tyr           
    190                 195                 200                           

ccc tac aaa gcc atg gat cag aaa tgt caa tat gac tca aaa tat cgt        793
Pro Tyr Lys Ala Met Asp Gln Lys Cys Gln Tyr Asp Ser Lys Tyr Arg           
205                 210                 215                 220           

gct gcc aca tgt tca aag tac act gaa ctt cct tat ggc aga gaa gat        841
Ala Ala Thr Cys Ser Lys Tyr Thr Glu Leu Pro Tyr Gly Arg Glu Asp           
                225                 230                 235               

gtc ctg aaa gaa gct gtg gcc aat aaa ggc cca gtg tct gtt ggt gta        889
Val Leu Lys Glu Ala Val Ala Asn Lys Gly Pro Val Ser Val Gly Val           
            240                 245                 250                   

gat gcg cgt cat cct tct ttc ttc ctc tac aga agt ggt gtc tac tat        937
Asp Ala Arg His Pro Ser Phe Phe Leu Tyr Arg Ser Gly Val Tyr Tyr           
        255                 260                 265                       

gaa cca tcc tgt act cag aat gtg aat cat ggt gta ctt gtg gtt ggc        985
Glu Pro Ser Cys Thr Gln Asn Val Asn His Gly Val Leu Val Val Gly           
    270                 275                 280                           

tat ggt gat ctt aat ggg aaa gaa tac tgg ctt gtg aaa aac agc tgg       1033
Tyr Gly Asp Leu Asn Gly Lys Glu Tyr Trp Leu Val Lys Asn Ser Trp           
285                 290                 295                 300           

ggc cac aac ttt ggt gaa gaa gga tat att cgg atg gca aga aat aaa       1081
Gly His Asn Phe Gly Glu Glu Gly Tyr Ile Arg Met Ala Arg Asn Lys           
                305                 310                 315               

gga aat cat tgt ggg att gct agc ttt ccc tct tac cca gaa atc tag       1129
Gly Asn His Cys Gly Ile Ala Ser Phe Pro Ser Tyr Pro Glu Ile               
            320                 325                 330                   

aggatctctc ctttttataa caaatcaaga aatatgaagc actttctctt aacttaattt     1189

ttcctgctgt atccagaaga aataattgtg tcatgattaa tgtgtattta ctgtactaat     1249

tagaaaatat agtttgaggc cgggcacggt ggctcacgcc tgtaatccca gtacttggga     1309

ggccaaggca ggcatatcaa cttgaggcca ggagttaaag agcagcctgg ctaacatggt     1369

gaaaccccat ctctactaaa aatacaaaaa attagccgag cacggtggtg catgcctgta     1429

atcccagcta cttgggaggc tgaggcacga gattccttga acccaagagg ttgaggctat     1489

gttgagctga gatcacacca ctgtactcca gcctggatga cagagtggag actctgtttc     1549

aaaaaaacag aaaagaaaat atagtttgat tcttcatttt tttaaatttg caaatctcag     1609

gataaagttt gctaagtaaa ttagtaatgt actatagata taactgtaca aaaattgttc     1669

aacctaaaac aatctgtaat tgcttattgt tttattgtat actctttgtc tttttaagac     1729

ccctaatagc cttttgtaac ttgatggctt aaaaatactt aataaatctg ccatttcaaa     1789

tttctatcat tgccacatac cattcttatt cctaggcaac tattaataat ctatcctgag     1849

aatattaatt gtggtattct ggtgatgggg tttagcaact ttgatggaag aaaatattag     1909

gctataaatg tcctaaggac tcagattgta tctttgtaca gaagaggatt caaaacgcca     1969

cgtgtagtgg ctcatgcctg taatcccaac actttgggag gctgaagtag gaggatcgtc     2029

ttgagcccag gagttcaaga ccagcctgga caacatagtg agaccttgtc tccacaaaaa     2089

taaaaaagaa actatccagg agtggtggtg tgtgcctgtg gtccctgcta tgcagatgtc     2149

taagacagga ggatcacaag agcccaggag gttgagaatg cagtgagctt gtaattgcac     2209

cactgcactc cagcctgggt gacagagcaa gaccctgtct taaaaaaaga ggattcaaca     2269

catattttta tattatgtta aagtaaagaa atgcataaaa gacaagcact ttggaagaat     2329

tattttaatg atcaacaatt taatgtatta gtccaaatta tttttacgta gtcatcaaca     2389

atttgaccag ggcctttatt tggcaaataa ctgagccaac cagaataaaa taaccaatac     2449

tccactgctc atatttttat ctaattcaga tggatcttcc ttacaactgc tctagattag     2509

tagatgcatc taagcaggca gcaggaactt taaatttttt aagttcatgt ctatgacatg     2569

aacaatgtgt gggataatgt cattaatata tcctaaatta acctaaacgt atttcactaa     2629

ctctggctcc ttctccataa agcacatttt aaggaacaag aattgctaaa tataaaaaca     2689

taaataatac cataatacat ggctatcatc aaaagtgtat agaatattat agtttaaaag     2749

tatttagttg attacttttc agttttgttt tgttttttga gacggagtct cactctgttg     2809

cccaggctgg agtgcagtgg caccatctca gttcactgca acttctgcct cccgagttca     2869

agcgattctc ctgcctcagc ctcccgagta gctggaatta taggcgtgca ccaccacgcc     2929

cagctaattt ttgtattttt agtaaagaca gggttttgcc acattagcca ggctggtctc     2989

aaactcctga cctcaggtga tccacccacc ccagcctccc aaagtgctaa gattacaggc     3049

gtgagccact gagcccagcc tacttttcag tttttaacat aatttttgtt ttatccacaa     3109

cttttcaagt attgaaagta gaataaaaac atgggttctt agtctttagc tatctgttaa     3169

agcctatgaa tgccttctta aaatcatgtt tttaaatgca taaaatatat aggattacaa     3229

aggaatctaa ttatatcgaa atacagttat taaaatgtta aaagataagt ttgttatata     3289

ttaatatgca tgcttcttta taaatgcatt aaataagagt taatagctat cctaaatttg     3349

aaatagtgat aagcataatg aaaatagatg caaaaaacta atgtgatatg aaaatatctg     3409

ggtttttctt ttgatgatga agtattgcta atattaccgt ggtttatgaa ctatgttcag     3469

aattgaagaa aatcctaact ttcagttaga ggttagtgac ggggttcagg acaccctaca     3529

caaaatacag cactttgaca tattgaatat tttaagctga aggcatttga ggaaattgca     3589

gaagcaggaa ggtgactctg accttctgcc tgctgttctc cccagaagca gccataaaac     3649

ctgggaagga ttttctgacc ttcccctgaa gtagatcata agactgtcat gtaagaggtg     3709

ctctcctggc acccagagaa aaggagcatc cttacctcca aaagcacagg gacacaaaga     3769

ggaatctaaa caaacaggcc tctcagtttc ccccagttta ttacatttag cttgttcaca     3829

ctttgcccta tgacatttct acatcactgg ctgctcttca tcaaacctac tataaaaaac     3889

attcaagttc aactgtttct ttgggccttt atttccttat ggagcccctc gtgtcgtgta     3949

aaacttatat taaataaatg tgcatgcttt tctcttgcta atctctcttt tgttatagag     4009

atctcagccc taaacctagg atggatagaa ggaaacatat gttctcccct acattagtaa     4069

aaataaaaat ggaatttttt acccatacaa a                                    4100


<210>  2
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Arg Leu Val Cys Val Leu Leu Val Cys Ser Ser Ala Val Ala 
1               5                   10                  15      


Gln Leu His Lys Asp Pro Thr Leu Asp His His Trp His Leu Trp Lys 
            20                  25                  30          


Lys Thr Tyr Gly Lys Gln Tyr Lys Glu Lys Asn Glu Glu Ala Val Arg 
        35                  40                  45              


Arg Leu Ile Trp Glu Lys Asn Leu Lys Phe Val Met Leu His Asn Leu 
    50                  55                  60                  


Glu His Ser Met Gly Met His Ser Tyr Asp Leu Gly Met Asn His Leu 
65                  70                  75                  80  


Gly Asp Met Thr Ser Glu Glu Val Met Ser Leu Met Ser Ser Leu Arg 
                85                  90                  95      


Val Pro Ser Gln Trp Gln Arg Asn Ile Thr Tyr Lys Ser Asn Pro Asn 
            100                 105                 110         


Arg Ile Leu Pro Asp Ser Val Asp Trp Arg Glu Lys Gly Cys Val Thr 
        115                 120                 125             


Glu Val Lys Tyr Gln Gly Ser Cys Gly Ala Cys Trp Ala Phe Ser Ala 
    130                 135                 140                 


Val Gly Ala Leu Glu Ala Gln Leu Lys Leu Lys Thr Gly Lys Leu Val 
145                 150                 155                 160 


Ser Leu Ser Ala Gln Asn Leu Val Asp Cys Ser Thr Glu Lys Tyr Gly 
                165                 170                 175     


Asn Lys Gly Cys Asn Gly Gly Phe Met Thr Thr Ala Phe Gln Tyr Ile 
            180                 185                 190         


Ile Asp Asn Lys Gly Ile Asp Ser Asp Ala Ser Tyr Pro Tyr Lys Ala 
        195                 200                 205             


Met Asp Gln Lys Cys Gln Tyr Asp Ser Lys Tyr Arg Ala Ala Thr Cys 
    210                 215                 220                 


Ser Lys Tyr Thr Glu Leu Pro Tyr Gly Arg Glu Asp Val Leu Lys Glu 
225                 230                 235                 240 


Ala Val Ala Asn Lys Gly Pro Val Ser Val Gly Val Asp Ala Arg His 
                245                 250                 255     


Pro Ser Phe Phe Leu Tyr Arg Ser Gly Val Tyr Tyr Glu Pro Ser Cys 
            260                 265                 270         


Thr Gln Asn Val Asn His Gly Val Leu Val Val Gly Tyr Gly Asp Leu 
        275                 280                 285             


Asn Gly Lys Glu Tyr Trp Leu Val Lys Asn Ser Trp Gly His Asn Phe 
    290                 295                 300                 


Gly Glu Glu Gly Tyr Ile Arg Met Ala Arg Asn Lys Gly Asn His Cys 
305                 310                 315                 320 


Gly Ile Ala Ser Phe Pro Ser Tyr Pro Glu Ile 
                325                 330     


<210>  3
<211>  3231
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (272)..(1564)
<223>  Pbx2

<400>  3
ctctctcaca cacacccccg cttgggcctc ctctctctct ccggctccat tttctccgcc       60

gccgggggcc ggggtctcct gtggggggcc cagccggtat cccaggtctc ccttcagtgc      120

cggggtgaac ccccggggga gccgggagcc gggggcagac gggcgggggt tggggcggag      180

ggagcagcgg ccccagcgag tttgggggga gaagtaacca ggcgggggga ggggcggagc      240

agggaggggg cctcagggcc cccccccagc t atg gac gaa cgg cta ctg ggg         292
                                   Met Asp Glu Arg Leu Leu Gly            
                                   1               5                      

ccg ccc cct cca ggc ggg ggc cgg ggg ggc ctg gga ttg gtg agt ggg        340
Pro Pro Pro Pro Gly Gly Gly Arg Gly Gly Leu Gly Leu Val Ser Gly           
        10                  15                  20                        

gag cct ggg ggc cct ggc gag cct ccc ggt ggc gga gac ccc ggt ggg        388
Glu Pro Gly Gly Pro Gly Glu Pro Pro Gly Gly Gly Asp Pro Gly Gly           
    25                  30                  35                            

ggt agc ggg ggg gtc ccg gga ggc cga ggg aag caa gac atc ggg gac        436
Gly Ser Gly Gly Val Pro Gly Gly Arg Gly Lys Gln Asp Ile Gly Asp           
40                  45                  50                  55            

att ctg cag cag ata atg acc atc acc gac cag agc ctg gac gag gcc        484
Ile Leu Gln Gln Ile Met Thr Ile Thr Asp Gln Ser Leu Asp Glu Ala           
                60                  65                  70                

cag gcc aag aaa cac gcc cta aac tgc cac cga atg aag cct gct ctc        532
Gln Ala Lys Lys His Ala Leu Asn Cys His Arg Met Lys Pro Ala Leu           
            75                  80                  85                    

ttt agc gtc ctg tgt gaa atc aag gag aaa act ggc ctc agc att cgg        580
Phe Ser Val Leu Cys Glu Ile Lys Glu Lys Thr Gly Leu Ser Ile Arg           
        90                  95                  100                       

agc tcc cag gag gag gag ccg gtg gac cca cag ctg atg cgc ttg gac        628
Ser Ser Gln Glu Glu Glu Pro Val Asp Pro Gln Leu Met Arg Leu Asp           
    105                 110                 115                           

aac atg ctt ctg gca gag ggt gtg gct ggg ccc gag aaa ggg ggc ggc        676
Asn Met Leu Leu Ala Glu Gly Val Ala Gly Pro Glu Lys Gly Gly Gly           
120                 125                 130                 135           

tca gca gca gca gct gca gcc gct gca gcc tct ggt ggt ggt gtg tcc        724
Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Gly Gly Val Ser           
                140                 145                 150               

cct gac aac tcc atc gaa cac tcg gac tat cgc agc aaa ctt gcc cag        772
Pro Asp Asn Ser Ile Glu His Ser Asp Tyr Arg Ser Lys Leu Ala Gln           
            155                 160                 165                   

atc cgt cac ata tac cac tcg gag ctg gag aag tat gag cag gca tgt        820
Ile Arg His Ile Tyr His Ser Glu Leu Glu Lys Tyr Glu Gln Ala Cys           
        170                 175                 180                       

aat gag ttc acg acc cat gtc atg aac ctg ctg agg gag cag agc cgc        868
Asn Glu Phe Thr Thr His Val Met Asn Leu Leu Arg Glu Gln Ser Arg           
    185                 190                 195                           

acc agg ccc gtg gcc ccc aaa gag atg gaa cgc atg gtg agc atc atc        916
Thr Arg Pro Val Ala Pro Lys Glu Met Glu Arg Met Val Ser Ile Ile           
200                 205                 210                 215           

cat cga aag ttc agc gcc atc cag atg cag ctg aag cag agc acc tgc        964
His Arg Lys Phe Ser Ala Ile Gln Met Gln Leu Lys Gln Ser Thr Cys           
                220                 225                 230               

gag gct gtg atg atc ctg cgc tcc cgt ttc ctg gat gcc aga cga aag       1012
Glu Ala Val Met Ile Leu Arg Ser Arg Phe Leu Asp Ala Arg Arg Lys           
            235                 240                 245                   

cgc cgt aac ttc agc aaa cag gcc act gag gtc cta aat gag tat ttc       1060
Arg Arg Asn Phe Ser Lys Gln Ala Thr Glu Val Leu Asn Glu Tyr Phe           
        250                 255                 260                       

tac tcc cac ctg agt aac cca tat cct agt gag gag gcc aag gag gag       1108
Tyr Ser His Leu Ser Asn Pro Tyr Pro Ser Glu Glu Ala Lys Glu Glu           
    265                 270                 275                           

ctt gcc aag aag tgt ggc atc acc gtg tct cag gtc tcc aac tgg ttt       1156
Leu Ala Lys Lys Cys Gly Ile Thr Val Ser Gln Val Ser Asn Trp Phe           
280                 285                 290                 295           

ggc aac aag agg att cgc tat aag aaa aac atc gga aag ttc caa gag       1204
Gly Asn Lys Arg Ile Arg Tyr Lys Lys Asn Ile Gly Lys Phe Gln Glu           
                300                 305                 310               

gag gca aac atc tat gct gtc aag acc gcc gtg tca gtc acc cag ggg       1252
Glu Ala Asn Ile Tyr Ala Val Lys Thr Ala Val Ser Val Thr Gln Gly           
            315                 320                 325                   

ggc cac agc cgc acc agc tcc ccg aca ccc cct tcc tct gca ggc tct       1300
Gly His Ser Arg Thr Ser Ser Pro Thr Pro Pro Ser Ser Ala Gly Ser           
        330                 335                 340                       

ggc ggc tct ttc aat ctc tca gga tct gga gac atg ttt ctg ggg atg       1348
Gly Gly Ser Phe Asn Leu Ser Gly Ser Gly Asp Met Phe Leu Gly Met           
    345                 350                 355                           

cct ggg ctc aac gga gat tcc tat tct gct tcc cag gtg gaa tca ctc       1396
Pro Gly Leu Asn Gly Asp Ser Tyr Ser Ala Ser Gln Val Glu Ser Leu           
360                 365                 370                 375           

cga cac tcg atg ggg cca ggg ggc tat ggg gat aac ctc ggg gga ggc       1444
Arg His Ser Met Gly Pro Gly Gly Tyr Gly Asp Asn Leu Gly Gly Gly           
                380                 385                 390               

cag atg tac agc cca cgg gaa atg agg gca aat ggc agc tgg caa gag       1492
Gln Met Tyr Ser Pro Arg Glu Met Arg Ala Asn Gly Ser Trp Gln Glu           
            395                 400                 405                   

gct gtg acc ccc tct tca gtg aca tcc cca acg gag gga cca ggg agt       1540
Ala Val Thr Pro Ser Ser Val Thr Ser Pro Thr Glu Gly Pro Gly Ser           
        410                 415                 420                       

gtt cac tct gat acc tcc aac tga tcttgcccct cagggtcaca ggggtggggg      1594
Val His Ser Asp Thr Ser Asn                                               
    425                 430                                               

ctctcacaag gcgacttgaa gaggacgcag gcttccagag gacaaacccc aatacaggag     1654

aagcacaaga cagagaaggg ccaatggggt catcccctcc ctaacgagac tctctgtgct     1714

gggggtgcta attacatggc aggaagaatg gggcctctaa ggggagtgtg gggtctgtct     1774

ctcccttttt tccatctttt tcctctctcg ctttctttct tacacagaaa catacacata     1834

ccgagaaacc tatttctcag accccttttt ctcctctgtc tttctctctc cctctcccac     1894

acctcacaca cacatactcc cacttgcaac tattctgttt ctctcctggg ctcccccact     1954

ttcccttccc caccccactt gtatgctctg gaatctgtgg agacgccagc cctgcccaat     2014

cagagatgcc aaaaatgggg acatgacttc tggacagagg acatgggcca cgcccccatg     2074

catccccacc cccgcccctc cggacggctt acttacctca tacgcagctc atcttaaacc     2134

aatagaatcg ctcggtggac gagagtgtct gactcagata tctacctcgg agggagtttc     2194

tgctacttta gggaattatt gactgggctt tggggttgaa cttttttttt tttaaagaaa     2254

gaaaaagaaa ccctgggatc catctgtttt ttttgttgtt gttgttgttt ttgttgttgt     2314

tggtggtggt ggtggtggtg gttcttaatt tttaatttag tttggggaag tagcttgttt     2374

ttttttttat aaatatgttg atttcttgtc tttttttttt tttatttctt actttcccat     2434

attaggggtg atagccaaag gggttctggt aagagaaagg gggacaaaca gaactggtaa     2494

agaggccccc ctggctccag gcctgtccat caggaagtaa attttacagg gcaccaagct     2554

ttgcccccta aaatccctta ggtgttcttt gttcatgcag gcaggtttct gccgcatttg     2614

atgtggaggc agtgaagggc ttgccctgct ggcctctcat cccccttctt cccacaaccc     2674

ttgggcaggg ctggactcag taattttgag gaaattgaag atgccatctt cccctgtgag     2734

tgacatgtct ttaatttttt aaaaaactac tatttgaaaa ttggaggggg aagaatggga     2794

agggagttat tgccaaatat gttaaatatg ggttggggtg cttgtatatg tatcttcctc     2854

aatttcccca taaatgaggt atctttttgt cacaccaaaa tcaaggggta gggagaggga     2914

ggaggttgca aaaagccaga tgtgggggaa aagtaacatc aacactgtcc catcctcagc     2974

cctgaactag ctaccatctg atcccctcag acattctcag gattttacaa gactgtcaga     3034

gtggggaacc cctcccatta aagatccggg caggactggg gacaggttgg aagtgtgatg     3094

ggtggggggg tgggaggcat gggccggggg cagttctctc ctcacttgta aacttgtgta     3154

gtttcacaga aaaaaaacaa aatgcagttt taaataaaga aatttctttt ttccctggga     3214

aaaaaaaaaa aaaaaaa                                                    3231


<210>  4
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Glu Arg Leu Leu Gly Pro Pro Pro Pro Gly Gly Gly Arg Gly 
1               5                   10                  15      


Gly Leu Gly Leu Val Ser Gly Glu Pro Gly Gly Pro Gly Glu Pro Pro 
            20                  25                  30          


Gly Gly Gly Asp Pro Gly Gly Gly Ser Gly Gly Val Pro Gly Gly Arg 
        35                  40                  45              


Gly Lys Gln Asp Ile Gly Asp Ile Leu Gln Gln Ile Met Thr Ile Thr 
    50                  55                  60                  


Asp Gln Ser Leu Asp Glu Ala Gln Ala Lys Lys His Ala Leu Asn Cys 
65                  70                  75                  80  


His Arg Met Lys Pro Ala Leu Phe Ser Val Leu Cys Glu Ile Lys Glu 
                85                  90                  95      


Lys Thr Gly Leu Ser Ile Arg Ser Ser Gln Glu Glu Glu Pro Val Asp 
            100                 105                 110         


Pro Gln Leu Met Arg Leu Asp Asn Met Leu Leu Ala Glu Gly Val Ala 
        115                 120                 125             


Gly Pro Glu Lys Gly Gly Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala 
    130                 135                 140                 


Ala Ser Gly Gly Gly Val Ser Pro Asp Asn Ser Ile Glu His Ser Asp 
145                 150                 155                 160 


Tyr Arg Ser Lys Leu Ala Gln Ile Arg His Ile Tyr His Ser Glu Leu 
                165                 170                 175     


Glu Lys Tyr Glu Gln Ala Cys Asn Glu Phe Thr Thr His Val Met Asn 
            180                 185                 190         


Leu Leu Arg Glu Gln Ser Arg Thr Arg Pro Val Ala Pro Lys Glu Met 
        195                 200                 205             


Glu Arg Met Val Ser Ile Ile His Arg Lys Phe Ser Ala Ile Gln Met 
    210                 215                 220                 


Gln Leu Lys Gln Ser Thr Cys Glu Ala Val Met Ile Leu Arg Ser Arg 
225                 230                 235                 240 


Phe Leu Asp Ala Arg Arg Lys Arg Arg Asn Phe Ser Lys Gln Ala Thr 
                245                 250                 255     


Glu Val Leu Asn Glu Tyr Phe Tyr Ser His Leu Ser Asn Pro Tyr Pro 
            260                 265                 270         


Ser Glu Glu Ala Lys Glu Glu Leu Ala Lys Lys Cys Gly Ile Thr Val 
        275                 280                 285             


Ser Gln Val Ser Asn Trp Phe Gly Asn Lys Arg Ile Arg Tyr Lys Lys 
    290                 295                 300                 


Asn Ile Gly Lys Phe Gln Glu Glu Ala Asn Ile Tyr Ala Val Lys Thr 
305                 310                 315                 320 


Ala Val Ser Val Thr Gln Gly Gly His Ser Arg Thr Ser Ser Pro Thr 
                325                 330                 335     


Pro Pro Ser Ser Ala Gly Ser Gly Gly Ser Phe Asn Leu Ser Gly Ser 
            340                 345                 350         


Gly Asp Met Phe Leu Gly Met Pro Gly Leu Asn Gly Asp Ser Tyr Ser 
        355                 360                 365             


Ala Ser Gln Val Glu Ser Leu Arg His Ser Met Gly Pro Gly Gly Tyr 
    370                 375                 380                 


Gly Asp Asn Leu Gly Gly Gly Gln Met Tyr Ser Pro Arg Glu Met Arg 
385                 390                 395                 400 


Ala Asn Gly Ser Trp Gln Glu Ala Val Thr Pro Ser Ser Val Thr Ser 
                405                 410                 415     


Pro Thr Glu Gly Pro Gly Ser Val His Ser Asp Thr Ser Asn 
            420                 425                 430 


<210>  5
<211>  4150
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (160)..(714)
<223>  Grem1

<400>  5
actcggtgcg ccttccgcgg accgggcgac ccagtgcacg gccgccgcgt cactctcggt       60

cccgctgacc ccgcgccgag ccccggcggc tctggccgcg gccgcactca gcgccacgcg      120

tcgaaagcgc aggccccgag gacccgccgc actgacagt atg agc cgc aca gcc         174
                                           Met Ser Arg Thr Ala            
                                           1               5              

tac acg gtg gga gcc ctg ctt ctc ctc ttg ggg acc ctg ctg ccg gct        222
Tyr Thr Val Gly Ala Leu Leu Leu Leu Leu Gly Thr Leu Leu Pro Ala           
                10                  15                  20                

gct gaa ggg aaa aag aaa ggg tcc caa ggt gcc atc ccc ccg cca gac        270
Ala Glu Gly Lys Lys Lys Gly Ser Gln Gly Ala Ile Pro Pro Pro Asp           
            25                  30                  35                    

aag gcc cag cac aat gac tca gag cag act cag tcg ccc cag cag cct        318
Lys Ala Gln His Asn Asp Ser Glu Gln Thr Gln Ser Pro Gln Gln Pro           
        40                  45                  50                        

ggc tcc agg aac cgg ggg cgg ggc caa ggg cgg ggc act gcc atg ccc        366
Gly Ser Arg Asn Arg Gly Arg Gly Gln Gly Arg Gly Thr Ala Met Pro           
    55                  60                  65                            

ggg gag gag gtg ctg gag tcc agc caa gag gcc ctg cat gtg acg gag        414
Gly Glu Glu Val Leu Glu Ser Ser Gln Glu Ala Leu His Val Thr Glu           
70                  75                  80                  85            

cgc aaa tac ctg aag cga gac tgg tgc aaa acc cag ccg ctt aag cag        462
Arg Lys Tyr Leu Lys Arg Asp Trp Cys Lys Thr Gln Pro Leu Lys Gln           
                90                  95                  100               

acc atc cac gag gaa ggc tgc aac agt cgc acc atc atc aac cgc ttc        510
Thr Ile His Glu Glu Gly Cys Asn Ser Arg Thr Ile Ile Asn Arg Phe           
            105                 110                 115                   

tgt tac ggc cag tgc aac tct ttc tac atc ccc agg cac atc cgg aag        558
Cys Tyr Gly Gln Cys Asn Ser Phe Tyr Ile Pro Arg His Ile Arg Lys           
        120                 125                 130                       

gag gaa ggt tcc ttt cag tcc tgc tcc ttc tgc aag ccc aag aaa ttc        606
Glu Glu Gly Ser Phe Gln Ser Cys Ser Phe Cys Lys Pro Lys Lys Phe           
    135                 140                 145                           

act acc atg atg gtc aca ctc aac tgc cct gaa cta cag cca cct acc        654
Thr Thr Met Met Val Thr Leu Asn Cys Pro Glu Leu Gln Pro Pro Thr           
150                 155                 160                 165           

aag aag aag aga gtc aca cgt gtg aag cag tgt cgt tgc ata tcc atc        702
Lys Lys Lys Arg Val Thr Arg Val Lys Gln Cys Arg Cys Ile Ser Ile           
                170                 175                 180               

gat ttg gat taa gccaaatcca ggtgcaccca gcatgtccta ggaatgcagc            754
Asp Leu Asp                                                               
                                                                          

cccaggaagt cccagaccta aaacaaccag attcttactt ggcttaaacc tagaggccag      814

aagaaccccc agctgcctcc tggcaggagc ctgcttgtgc gtagttcgtg tgcatgagtg      874

tggatgggtg cctgtgggtg tttttagaca ccagagaaaa cacagtctct gctagagagc      934

actccctatt ttgtaaacat atctgcttta atggggatgt accagaaacc cacctcaccc      994

cggctcacat ctaaaggggc ggggccgtgg tctggttctg actttgtgtt tttgtgccct     1054

cctggggacc agaatctcct ttcggaatga atgttcatgg aagaggctcc tctgagggca     1114

agagacctgt tttagtgctg cattcgacat ggaaaagtcc ttttaacctg tgcttgcatc     1174

ctcctttcct cctcctcctc acaatccatc tcttcttaag ttgatagtga ctatgtcagt     1234

ctaatctctt gtttgccaag gttcctaaat taattcactt aaccatgatg caaatgtttt     1294

tcattttgtg aagaccctcc agactctggg agaggctggt gtgggcaagg acaagcagga     1354

tagtggagtg agaaagggag ggtggagggt gaggccaaat caggtccagc aaaagtcagt     1414

agggacattg cagaagcttg aaaggccaat accagaacac aggctgatgc ttctgagaaa     1474

gtcttttcct agtatttaac agaacccaag tgaacagagg agaaatgaga ttgccagaaa     1534

gtgattaact ttggccgttg caatctgctc aaacctaaca ccaaactgaa aacataaata     1594

ctgaccactc ctatgttcgg acccaagcaa gttagctaaa ccaaaccaac tcctctgctt     1654

tgtccctcag gtggaaaaga gaggtagttt agaactctct gcataggggt gggaattaat     1714

caaaaacctc agaggctgaa attcctaata cctttccttt atcgtggtta tagtcagctc     1774

atttccattc cactatttcc cataatgctt ctgagagcca ctaacttgat tgataaagat     1834

cctgcctctg ctgagtgtac ctgacagtag tctaagatga gagagtttag ggactactct     1894

gttttagcaa gagatatttt gggggtcttt ttgttttaac tattgtcagg agattgggct     1954

aaagagaaga cgacgagagt aaggaaataa agggaattgc ctctggctag agagtagtta     2014

ggtgttaata cctggtagag atgtaaggga tatgacctcc ctttctttat gtgctcactg     2074

aggatctgag gggaccctgt taggagagca tagcatcatg atgtattagc tgttcatctg     2134

ctactggttg gatggacata actattgtaa ctattcagta tttactggta ggcactgtcc     2194

tctgattaaa cttggcctac tggcaatggc tacttaggat tgatctaagg gccaaagtgc     2254

agggtgggtg aactttattg tactttggat ttggttaacc tgttttcttc aagcctgagg     2314

ttttatatac aaactccctg aatactcttt ttgccttgta tcttctcagc ctcctagcca     2374

agtcctatgt aatatggaaa acaaacactg cagacttgag attcagttgc cgatcaaggc     2434

tctggcattc agagaaccct tgcaactcga gaagctgttt ttatttcgtt tttgttttga     2494

tccagtgctc tcccatctaa caactaaaca ggagccattt caaggcggga gatattttaa     2554

acacccaaaa tgttgggtct gattttcaaa cttttaaact cactactgat gattctcacg     2614

ctaggcgaat ttgtccaaac acatagtgtg tgtgttttgt atacactgta tgaccccacc     2674

ccaaatcttt gtattgtcca cattctccaa caataaagca cagagtggat ttaattaagc     2734

acacaaatgc taaggcagaa ttttgagggt gggagagaag aaaagggaaa gaagctgaaa     2794

atgtaaaacc acaccaggga ggaaaaatga cattcagaac cagcaaacac tgaatttctc     2854

ttgttgtttt aactctgcca caagaatgca atttcgttaa cggagatgac ttaagttggc     2914

agcagtaatc ttcttttagg agcttgtacc acagtcttgc acataagtgc agatttggct     2974

caagtaaaga gaatttcctc aacactaact tcactgggat aatcagcagc gtaactaccc     3034

taaaagcata tcactagcca aagagggaaa tatctgttct tcttactgtg cctatattaa     3094

gactagtaca aatgtggtgt gtcttccaac tttcattgaa aatgccatat ctataccata     3154

ttttattcga gtcactgatg atgtaatgat atattttttc attattatag tagaatattt     3214

ttatggcaag atatttgtgg tcttgatcat acctattaaa ataatgccaa acaccaaata     3274

tgaattttat gatgtacact ttgtgcttgg cattaaaaga aaaaaacaca catcctggaa     3334

gtctgtaagt tgttttttgt tactgtaggt cttcaaagtt aagagtgtaa gtgaaaaatc     3394

tggaggagag gataatttcc actgtgtgga atgtgaatag ttaaatgaaa agttatggtt     3454

atttaatgta attattactt caaatccttt ggtcactgtg atttcaagca tgttttcttt     3514

ttctccttta tatgactttc tctgagttgg gcaaagaaga agctgacaca ccgtatgttg     3574

ttagagtctt ttatctggtc aggggaaaca aaatcttgac ccagctgaac atgtcttcct     3634

gagtcagtgc ctgaatcttt attttttaaa ttgaatgttc cttaaaggtt aacatttcta     3694

aagcaatatt aagaaagact ttaaatgtta ttttggaaga cttacgatgc atgtatacaa     3754

acgaatagca gataatgatg actagttcac acataaagtc cttttaagga gaaaatctaa     3814

aatgaaaagt ggataaacag aacatttata agtgatcagt taatgcctaa gagtgaaagt     3874

agttctattg acattcctca agatatttaa tatcaactgc attatgtatt atgtctgctt     3934

aaatcattta aaaacggcaa agaattatat agactatgag gtaccttgct gtgtaggagg     3994

atgaaagggg agttgatagt ctcataaaac taatttggct tcaagtttca tgaatctgta     4054

actagaattt aattttcacc ccaataatgt tctatatagc ctttgctaaa gagcaactaa     4114

taaattaaac ctattctttc tgtgaaaaaa aaaaaa                               4150


<210>  6
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Arg Thr Ala Tyr Thr Val Gly Ala Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Thr Leu Leu Pro Ala Ala Glu Gly Lys Lys Lys Gly Ser Gln Gly Ala 
            20                  25                  30          


Ile Pro Pro Pro Asp Lys Ala Gln His Asn Asp Ser Glu Gln Thr Gln 
        35                  40                  45              


Ser Pro Gln Gln Pro Gly Ser Arg Asn Arg Gly Arg Gly Gln Gly Arg 
    50                  55                  60                  


Gly Thr Ala Met Pro Gly Glu Glu Val Leu Glu Ser Ser Gln Glu Ala 
65                  70                  75                  80  


Leu His Val Thr Glu Arg Lys Tyr Leu Lys Arg Asp Trp Cys Lys Thr 
                85                  90                  95      


Gln Pro Leu Lys Gln Thr Ile His Glu Glu Gly Cys Asn Ser Arg Thr 
            100                 105                 110         


Ile Ile Asn Arg Phe Cys Tyr Gly Gln Cys Asn Ser Phe Tyr Ile Pro 
        115                 120                 125             


Arg His Ile Arg Lys Glu Glu Gly Ser Phe Gln Ser Cys Ser Phe Cys 
    130                 135                 140                 


Lys Pro Lys Lys Phe Thr Thr Met Met Val Thr Leu Asn Cys Pro Glu 
145                 150                 155                 160 


Leu Gln Pro Pro Thr Lys Lys Lys Arg Val Thr Arg Val Lys Gln Cys 
                165                 170                 175     


Arg Cys Ile Ser Ile Asp Leu Asp 
            180                 


<210>  7
<211>  652
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Ly6g6e

<400>  7
agagacaaca tgctgagaga gcagaggaga ccctccaggc aagggcagac tccttgcagg       60

ggcaggctgg gggcccccgc tgcctgctgg gtcaggctgg tgaatctggt catggttccg      120

ccccccagat tcactcccta ggtgtgtttg tttactggtt cctcactgtc ttgctcaaat      180

gctccaactc tacaaatccc gggatctcgg ggtgcagatc acctctccca gattcctgag      240

cctgtgtctg gccatgggca cctccagcat cttcctctgc gtgctgttcc tctgtggggc      300

actgggtctc accatgtccc ctgcccgggg aaggctccgc tgctacatct gtggcttcac      360

caaaccctgc caccctgttc ccaccgagtg tcgggacgat gaagcttgtg gcatcagtat      420

tggcacttca gaccagagtg agatcactga gtgaaaaagc tgcctctcaa gggcccagtg      480

ccctctgcca ggctatgcca cctactggct gcactcctac actctgtggc accactgctg      540

cgagcaggac ctgtgcaaca tagccgcttc cccacagcag ctcaccagcc tcctcgcctc      600

cctgcccctc tttgtggcca gcttcgctgg gagaggacac ctcctccact ag              652


<210>  8
<211>  2533
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (115)..(936)
<223>  Olr1

<400>  8
attcttctat tagataacag tagctattta aatacttctg cagaagctca catattttta       60

gtttgttgaa gttcgtgact gcttcactct ctcattctta gcttgaattt ggaa atg        117
                                                            Met           
                                                            1             

act ttt gat gac cta aag atc cag act gtg aag gac cag cct gat gag        165
Thr Phe Asp Asp Leu Lys Ile Gln Thr Val Lys Asp Gln Pro Asp Glu           
            5                   10                  15                    

aag tca aat gga aaa aaa gct aaa ggt ctt cag ttt ctt tac tct cca        213
Lys Ser Asn Gly Lys Lys Ala Lys Gly Leu Gln Phe Leu Tyr Ser Pro           
        20                  25                  30                        

tgg tgg tgc ctg gct gct gcg act cta ggg gtc ctt tgc ctg gga tta        261
Trp Trp Cys Leu Ala Ala Ala Thr Leu Gly Val Leu Cys Leu Gly Leu           
    35                  40                  45                            

gta gtg acc att atg gtg ctg ggc atg caa tta tcc cag gtg tct gac        309
Val Val Thr Ile Met Val Leu Gly Met Gln Leu Ser Gln Val Ser Asp           
50                  55                  60                  65            

ctc cta aca caa gag caa gca aac cta act cac cag aaa aag aaa ctg        357
Leu Leu Thr Gln Glu Gln Ala Asn Leu Thr His Gln Lys Lys Lys Leu           
                70                  75                  80                

gag gga cag atc tca gcc cgg caa caa gca gaa gaa gct tca cag gag        405
Glu Gly Gln Ile Ser Ala Arg Gln Gln Ala Glu Glu Ala Ser Gln Glu           
            85                  90                  95                    

tca gaa aac gaa ctc aag gaa atg ata gaa acc ctt gct cgg aag ctg        453
Ser Glu Asn Glu Leu Lys Glu Met Ile Glu Thr Leu Ala Arg Lys Leu           
        100                 105                 110                       

aat gag aaa tcc aaa gag caa atg gaa ctt cac cac cag aat ctg aat        501
Asn Glu Lys Ser Lys Glu Gln Met Glu Leu His His Gln Asn Leu Asn           
    115                 120                 125                           

ctc caa gaa aca ctg aag aga gta gca aat tgt tca gct cct tgt ccg        549
Leu Gln Glu Thr Leu Lys Arg Val Ala Asn Cys Ser Ala Pro Cys Pro           
130                 135                 140                 145           

caa gac tgg atc tgg cat gga gaa aac tgt tac cta ttt tcc tcg ggc        597
Gln Asp Trp Ile Trp His Gly Glu Asn Cys Tyr Leu Phe Ser Ser Gly           
                150                 155                 160               

tca ttt aac tgg gaa aag agc caa gag aag tgc ttg tct ttg gat gcc        645
Ser Phe Asn Trp Glu Lys Ser Gln Glu Lys Cys Leu Ser Leu Asp Ala           
            165                 170                 175                   

aag ttg ctg aaa att aat agc aca gct gat ctg gac ttc atc cag caa        693
Lys Leu Leu Lys Ile Asn Ser Thr Ala Asp Leu Asp Phe Ile Gln Gln           
        180                 185                 190                       

gca att tcc tat tcc agt ttt cca ttc tgg atg ggg ctg tct cgg agg        741
Ala Ile Ser Tyr Ser Ser Phe Pro Phe Trp Met Gly Leu Ser Arg Arg           
    195                 200                 205                           

aac ccc agc tac cca tgg ctc tgg gag gac ggt tct cct ttg atg ccc        789
Asn Pro Ser Tyr Pro Trp Leu Trp Glu Asp Gly Ser Pro Leu Met Pro           
210                 215                 220                 225           

cac tta ttt aga gtc cga ggc gct gtc tcc cag aca tac cct tca ggt        837
His Leu Phe Arg Val Arg Gly Ala Val Ser Gln Thr Tyr Pro Ser Gly           
                230                 235                 240               

acc tgt gca tat ata caa cga gga gct gtt tat gcg gaa aac tgc att        885
Thr Cys Ala Tyr Ile Gln Arg Gly Ala Val Tyr Ala Glu Asn Cys Ile           
            245                 250                 255                   

tta gct gcc ttc agt ata tgt cag aag aag gca aac cta aga gca cag        933
Leu Ala Ala Phe Ser Ile Cys Gln Lys Lys Ala Asn Leu Arg Ala Gln           
        260                 265                 270                       

tga atttgaaggc tctggaagaa aagaaaaaag tctttgagtt ttattctgga             986

atttaagcta ttctttgtca cttgggtgcc aaacatgaga gcccagaaaa ctgtcattta     1046

gctggctgca gaactccttt gcagaaactg gggttccagg tgcctggcac ctttatgtca     1106

acatttttga ttctagctac ctgtattatt tcacctagct tgtcccaagc ttccctgcca     1166

gcctgaagtc cattttcccc tttttatttt aaaatttgac tcctcttcaa gcttgaaaac     1226

cctctgaact cagtcttctt tacctcatta tcaccttccc ctcacactcc taaaattgca     1286

tgaaagacag aacatggaga acttgctcaa gtgcaggcag agagcaaaaa ggggaaatat     1346

gtctgggaaa aagtgcacgt gaagaaacaa agaaggacag aggccattcc gaaatcaaga     1406

aactcatgtt cttaacttta aaaaaggtat caatccttgg tttttaaact gtggtccatc     1466

tccagactct accacttacg gacagacaga cagacagaca cacacacaca cacacacaca     1526

cattttggga caagtgggga gcccaagaaa gtaattagta agtgagtggt cttttctgta     1586

agctaatcca caacctgtta ccacttcctg aatcagttat tatttcttca tttttttttc     1646

taccagagga cagattaata gatttaaccc ttcacaacag ttcttgttag aatcatggga     1706

tgtgtggccc agaggtaaga atagaatttc tttccctaaa gaacatacct tttgtagatg     1766

aactcttctc aactctgttt tgctatgcta taattccgaa acatacaaga caaaaaaaat     1826

gaagacactc aatctagaac aaactaagcc aggtatgcaa atatcgctga atagaaacag     1886

atggaattag aaatatatct tctattttta ggcttctatt tcctttccac ccactcttca     1946

caggctattc tactttaaag gaagcctttt tattttgctg cacacaatct agcaggaatc     2006

tttttttttt tttaagagct gtgtcatcct tatgtaggca agagatgttt gcttttgtta     2066

aaagctttat tgagatataa ttaacataaa ataaactgaa catatttaaa gtgtactatt     2126

tgataagttt tcacaccttg tggagaacat gcatactaca attaagagag tgaacatatc     2186

catcatccct caaagtgtca caatgctcct cctgatgact cctccccaga aaaccaccaa     2246

tcggctttca ttttgcattt tgtagtttta tgtgaatgga atcatatagt atgtcttttt     2306

tttttgtctg gcttctttca ctttgcataa ttattttgag attcatatgt ctccatcttg     2366

atgctcgtat gaattcattc ttttaaatgt tgaatattcc cttgtatgga tataccacaa     2426

ttcatttacc catttacttg ttgatgacat ttgggttgtt ttagttttgg gatattacaa     2486

ataaagctgc tgtgaacatt tgtgtacaag aaaaaaaaaa aaaaaaa                   2533


<210>  9
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Thr Phe Asp Asp Leu Lys Ile Gln Thr Val Lys Asp Gln Pro Asp 
1               5                   10                  15      


Glu Lys Ser Asn Gly Lys Lys Ala Lys Gly Leu Gln Phe Leu Tyr Ser 
            20                  25                  30          


Pro Trp Trp Cys Leu Ala Ala Ala Thr Leu Gly Val Leu Cys Leu Gly 
        35                  40                  45              


Leu Val Val Thr Ile Met Val Leu Gly Met Gln Leu Ser Gln Val Ser 
    50                  55                  60                  


Asp Leu Leu Thr Gln Glu Gln Ala Asn Leu Thr His Gln Lys Lys Lys 
65                  70                  75                  80  


Leu Glu Gly Gln Ile Ser Ala Arg Gln Gln Ala Glu Glu Ala Ser Gln 
                85                  90                  95      


Glu Ser Glu Asn Glu Leu Lys Glu Met Ile Glu Thr Leu Ala Arg Lys 
            100                 105                 110         


Leu Asn Glu Lys Ser Lys Glu Gln Met Glu Leu His His Gln Asn Leu 
        115                 120                 125             


Asn Leu Gln Glu Thr Leu Lys Arg Val Ala Asn Cys Ser Ala Pro Cys 
    130                 135                 140                 


Pro Gln Asp Trp Ile Trp His Gly Glu Asn Cys Tyr Leu Phe Ser Ser 
145                 150                 155                 160 


Gly Ser Phe Asn Trp Glu Lys Ser Gln Glu Lys Cys Leu Ser Leu Asp 
                165                 170                 175     


Ala Lys Leu Leu Lys Ile Asn Ser Thr Ala Asp Leu Asp Phe Ile Gln 
            180                 185                 190         


Gln Ala Ile Ser Tyr Ser Ser Phe Pro Phe Trp Met Gly Leu Ser Arg 
        195                 200                 205             


Arg Asn Pro Ser Tyr Pro Trp Leu Trp Glu Asp Gly Ser Pro Leu Met 
    210                 215                 220                 


Pro His Leu Phe Arg Val Arg Gly Ala Val Ser Gln Thr Tyr Pro Ser 
225                 230                 235                 240 


Gly Thr Cys Ala Tyr Ile Gln Arg Gly Ala Val Tyr Ala Glu Asn Cys 
                245                 250                 255     


Ile Leu Ala Ala Phe Ser Ile Cys Gln Lys Lys Ala Asn Leu Arg Ala 
            260                 265                 270         


Gln 
    


<210>  10
<211>  1185
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (325)..(735)
<223>  Spr1

<400>  10
gtgattacgg agatgccaag tgggtattga ctgctccagg atgtggatgg agggtgtgaa       60

aaccagggtg gggtgacgca ggctctgggt catgataggg agagcaggca gctgggtcct      120

gggctggagg actaaaataa gggacgccac cttcaggggt gacacatcag cccaggcctt      180

cccaacgggt ttgaccagtt ctgttctgat ggtattcctg tgccactggg ctggtccctc      240

ctccactcct cccctataaa gcctcttggg gttcccaggc acccagactc agcccacccc      300

agctttgggg gccagtacat agcc atg atc ctc aac tgg aag ctc ctg ggg         351
                           Met Ile Leu Asn Trp Lys Leu Leu Gly            
                           1               5                              

atc ctg gtc ctt tgc ctg cac acc aga ggc atc tca ggc agc gag ggc        399
Ile Leu Val Leu Cys Leu His Thr Arg Gly Ile Ser Gly Ser Glu Gly           
10                  15                  20                  25            

cac ccc tct cac cca ccc gca gag gac cga gag gag gca ggc tcc cca        447
His Pro Ser His Pro Pro Ala Glu Asp Arg Glu Glu Ala Gly Ser Pro           
                30                  35                  40                

aca ttg cct cag ggc ccc cca gtc ccc ggt gac cct tgg cca ggg gca        495
Thr Leu Pro Gln Gly Pro Pro Val Pro Gly Asp Pro Trp Pro Gly Ala           
            45                  50                  55                    

ccc cct ctc ttt gaa gat cct ccg cct acc cgc ccc agt cgt ccc tgg        543
Pro Pro Leu Phe Glu Asp Pro Pro Pro Thr Arg Pro Ser Arg Pro Trp           
        60                  65                  70                        

aga gac ctg cct gaa act gga gtc tgg ctc cct gaa ccg cct aga acg        591
Arg Asp Leu Pro Glu Thr Gly Val Trp Leu Pro Glu Pro Pro Arg Thr           
    75                  80                  85                            

gat cct cct caa cct ccc cgg cct gac gac cct tgg ccg gca gga ccc        639
Asp Pro Pro Gln Pro Pro Arg Pro Asp Asp Pro Trp Pro Ala Gly Pro           
90                  95                  100                 105           

cag ccc cca gaa aac ccc tgg cct cct gcc cct gag gtg gac aac cga        687
Gln Pro Pro Glu Asn Pro Trp Pro Pro Ala Pro Glu Val Asp Asn Arg           
                110                 115                 120               

cct cag gag gag cca gac cta gac cca ccc cgg gaa gag tac aga taa        735
Pro Gln Glu Glu Pro Asp Leu Asp Pro Pro Arg Glu Glu Tyr Arg               
            125                 130                 135                   

tggagtcccc tcagccgttc tgttcccagg catctccagg cacccacgcc ctctccaccc      795

tctgattccc cgtgaattct tcccaattta gcctgtctcc ttaaacctct tcctcattcc      855

ctcggtttta ttctgaaccc gtaaggtggt gttctcaata tttcctgtcc cctcctgaga      915

tccatactta gtcctcacat cgcccgtttt ttcctctgac agcctaagcc tactctccta      975

cctcgcctcc aggcctcggc cgcacctacc tcccacccgg tcttcctgcc cgcgcgatcg     1035

ctggggcagg gctatggtac tgtgttccct tctgccacct ggtggccggc ggcaggaact     1095

atcagtagac agctgctgct tccatgaaac ggaaaaataa aaatcatgtt ttcttaaaaa     1155

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                      1185


<210>  11
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ile Leu Asn Trp Lys Leu Leu Gly Ile Leu Val Leu Cys Leu His 
1               5                   10                  15      


Thr Arg Gly Ile Ser Gly Ser Glu Gly His Pro Ser His Pro Pro Ala 
            20                  25                  30          


Glu Asp Arg Glu Glu Ala Gly Ser Pro Thr Leu Pro Gln Gly Pro Pro 
        35                  40                  45              


Val Pro Gly Asp Pro Trp Pro Gly Ala Pro Pro Leu Phe Glu Asp Pro 
    50                  55                  60                  


Pro Pro Thr Arg Pro Ser Arg Pro Trp Arg Asp Leu Pro Glu Thr Gly 
65                  70                  75                  80  


Val Trp Leu Pro Glu Pro Pro Arg Thr Asp Pro Pro Gln Pro Pro Arg 
                85                  90                  95      


Pro Asp Asp Pro Trp Pro Ala Gly Pro Gln Pro Pro Glu Asn Pro Trp 
            100                 105                 110         


Pro Pro Ala Pro Glu Val Asp Asn Arg Pro Gln Glu Glu Pro Asp Leu 
        115                 120                 125             


Asp Pro Pro Arg Glu Glu Tyr Arg 
    130                 135     


<210>  12
<211>  3761
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (199)..(1554)
<223>  Msr1

<400>  12
aaatttagat tttgcaaacc tgtgcattga tgagagtgct attgaaacac attaagaaag       60

attttcaacg caggaatgtg tcatttcctt tcttcatgta ccagatgctg aaatactatg      120

agataaagat tttaggtttc aattgtaaag agagagaagt ggataaatca gtgctgcttt      180

ctttaggacg aaagaagt atg gag cag tgg gat cac ttt cac aat caa cag        231
                    Met Glu Gln Trp Asp His Phe His Asn Gln Gln           
                    1               5                   10                

gag gac act gat agc tgc tcc gaa tct gtg aaa ttt gat gct cgc tca        279
Glu Asp Thr Asp Ser Cys Ser Glu Ser Val Lys Phe Asp Ala Arg Ser           
            15                  20                  25                    

atg aca gct ttg ctt cct ccg aat cct aaa aac agc cct tcc ctt caa        327
Met Thr Ala Leu Leu Pro Pro Asn Pro Lys Asn Ser Pro Ser Leu Gln           
        30                  35                  40                        

gag aaa ctg aag tcc ttc aaa gct gca ctg att gcc ctt tac ctc ctc        375
Glu Lys Leu Lys Ser Phe Lys Ala Ala Leu Ile Ala Leu Tyr Leu Leu           
    45                  50                  55                            

gtg ttt gca gtt ctc atc cct ctc att gga ata gtg gca gct caa ctc        423
Val Phe Ala Val Leu Ile Pro Leu Ile Gly Ile Val Ala Ala Gln Leu           
60                  65                  70                  75            

ctg aag tgg gaa acg aag aat tgc tca gtt agt tca act aat gca aat        471
Leu Lys Trp Glu Thr Lys Asn Cys Ser Val Ser Ser Thr Asn Ala Asn           
                80                  85                  90                

gat ata act caa agt ctc acg gga aaa gga aat gac agc gaa gag gaa        519
Asp Ile Thr Gln Ser Leu Thr Gly Lys Gly Asn Asp Ser Glu Glu Glu           
            95                  100                 105                   

atg aga ttt caa gaa gtc ttt atg gaa cac atg agc aac atg gag aag        567
Met Arg Phe Gln Glu Val Phe Met Glu His Met Ser Asn Met Glu Lys           
        110                 115                 120                       

aga atc cag cat att tta gac atg gaa gcc aac ctc atg gac aca gag        615
Arg Ile Gln His Ile Leu Asp Met Glu Ala Asn Leu Met Asp Thr Glu           
    125                 130                 135                           

cat ttc caa aat ttc agc atg aca act gat caa aga ttt aat gac att        663
His Phe Gln Asn Phe Ser Met Thr Thr Asp Gln Arg Phe Asn Asp Ile           
140                 145                 150                 155           

ctt ctg cag cta agt acc ttg ttt tcc tca gtc cag gga cat ggg aat        711
Leu Leu Gln Leu Ser Thr Leu Phe Ser Ser Val Gln Gly His Gly Asn           
                160                 165                 170               

gca ata gat gaa atc tcc aag tcc tta ata agt ttg aat acc aca ttg        759
Ala Ile Asp Glu Ile Ser Lys Ser Leu Ile Ser Leu Asn Thr Thr Leu           
            175                 180                 185                   

ctt gat ttg cag ctc aac ata gaa aat ctg aat ggc aaa atc caa gag        807
Leu Asp Leu Gln Leu Asn Ile Glu Asn Leu Asn Gly Lys Ile Gln Glu           
        190                 195                 200                       

aat acc ttc aaa caa caa gag gaa atc agt aaa tta gag gag cgt gtt        855
Asn Thr Phe Lys Gln Gln Glu Glu Ile Ser Lys Leu Glu Glu Arg Val           
    205                 210                 215                           

tac aat gta tca gca gaa att atg gct atg aaa gaa gaa caa gtg cat        903
Tyr Asn Val Ser Ala Glu Ile Met Ala Met Lys Glu Glu Gln Val His           
220                 225                 230                 235           

ttg gaa cag gaa ata aaa gga gaa gtg aaa gta ctg aat aac atc act        951
Leu Glu Gln Glu Ile Lys Gly Glu Val Lys Val Leu Asn Asn Ile Thr           
                240                 245                 250               

aat gat ctc aga ctg aaa gat tgg gaa cat tct cag acc ttg aga aat        999
Asn Asp Leu Arg Leu Lys Asp Trp Glu His Ser Gln Thr Leu Arg Asn           
            255                 260                 265                   

atc act tta att caa ggt cct cct gga ccc ccg ggt gaa aaa gga gat       1047
Ile Thr Leu Ile Gln Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Asp           
        270                 275                 280                       

cga ggt ccc act gga gaa agt ggt cca cga gga ttt cca ggt cca ata       1095
Arg Gly Pro Thr Gly Glu Ser Gly Pro Arg Gly Phe Pro Gly Pro Ile           
    285                 290                 295                           

ggt cct ccg ggt ctt aaa ggt gat cgg gga gca att ggc ttt cct gga       1143
Gly Pro Pro Gly Leu Lys Gly Asp Arg Gly Ala Ile Gly Phe Pro Gly           
300                 305                 310                 315           

agt cga gga ctc cca gga tat gcc gga agg cca gga aat tct gga cca       1191
Ser Arg Gly Leu Pro Gly Tyr Ala Gly Arg Pro Gly Asn Ser Gly Pro           
                320                 325                 330               

aaa ggc cag aaa ggg gaa aag ggg agt gga aac aca tta act cca ttt       1239
Lys Gly Gln Lys Gly Glu Lys Gly Ser Gly Asn Thr Leu Thr Pro Phe           
            335                 340                 345                   

acg aaa gtt cga ctg gtc ggt ggg agc ggc cct cac gag ggg agg gtg       1287
Thr Lys Val Arg Leu Val Gly Gly Ser Gly Pro His Glu Gly Arg Val           
        350                 355                 360                       

gag ata ctc cac agc ggc cag tgg ggt aca att tgt gac gat cgc tgg       1335
Glu Ile Leu His Ser Gly Gln Trp Gly Thr Ile Cys Asp Asp Arg Trp           
    365                 370                 375                           

gaa gtg cgc gtt gga cag gtc gtc tgt agg agc ttg gga tac cca ggt       1383
Glu Val Arg Val Gly Gln Val Val Cys Arg Ser Leu Gly Tyr Pro Gly           
380                 385                 390                 395           

gtt caa gcc gtg cac aag gca gct cac ttt gga caa ggt act ggt cca       1431
Val Gln Ala Val His Lys Ala Ala His Phe Gly Gln Gly Thr Gly Pro           
                400                 405                 410               

ata tgg ctg aat gaa gtg ttt tgt ttt ggg aga gaa tca tct att gaa       1479
Ile Trp Leu Asn Glu Val Phe Cys Phe Gly Arg Glu Ser Ser Ile Glu           
            415                 420                 425                   

gaa tgt aaa att cgg caa tgg ggg aca aga gcc tgt tca cat tct gaa       1527
Glu Cys Lys Ile Arg Gln Trp Gly Thr Arg Ala Cys Ser His Ser Glu           
        430                 435                 440                       

gat gct gga gtc act tgc act tta taa tgcatcatat tttcattcac             1574
Asp Ala Gly Val Thr Cys Thr Leu                                           
    445                 450                                               

aactatgaaa tcgctgctca aaaatgattt tattaccttg ttcctgtaaa atccatttaa     1634

tcaatattta agagattaag aatattgccc aaataatatt ttagattaca ggattaatat     1694

attgaacacc ttcatgctta ctattttatg tctatattta aatcatttta acttctatag     1754

gtttttaaat ggaattttct aatataatga cttatatgct gaattgaaca ttttgaagtt     1814

tatagcttcc agattacaaa ggccaagggt aatagaaatg cataccagta attggctcca     1874

attcataata tgttcaccag gagattacaa ttttttgctc ttcttgtctt tgtaatctat     1934

ttagttgatt ttaattactt tctgaataac ggaagggatc agaagatatc ttttgtgcct     1994

agattgcaaa atctccaatc cacacatatt gttttaaaat aagaatgtta tccaactatt     2054

aagatatctc aatgtgcaat aacttgtgta ttagatatca atgttaatga tatgtcttgg     2114

ccactatgga ccagggagct tatttttctt gtcatgtact gacaactgtt taattgaatc     2174

atgaagtaaa ttgaaagcag gacatatgag aaaactgacc atcagtatat ttgtccagat     2234

aattggtgga tcaaaaatgc cacttaacag gaagtttagt ttgttatgca ctttaaatgg     2294

aataattagc ttgttacaat tctaggacat ggtgtttaaa atttaaatct gattaatcca     2354

ttttaacaaa caatgcaaac atcttcagtg cagaaggaag agtggtttca actgtttgga     2414

gtcttttatg aagtcagtca acatttacaa ccaaagggcg gggggggggg tggggggtgc     2474

gtctttagtc ctaaagggac aataactctg agcatgcccc aaaaaagtag tttagcaacc     2534

ttttgttggt agtcaaccca tccccagggc catagtgtag agtgtgaaaa gctaccctga     2594

aacccagtaa ttctaccctg aaagtgactg cctgcagaaa gaccagcagt tgatattaaa     2654

gcgcaaatga attcaacctc agccctgaaa ataacagaat tctgaagttt cctatgacta     2714

attcacaaaa aaagtaattg taaactagta ctattatgga attactctac tgttctttct     2774

ttaatagtgg caaatgaaag cataagctta agcatttttt catattctga agtctcacca     2834

cacataataa ccaagtggta gactcacagc cgtccaactt aaaaaggcaa aaccttacct     2894

tggaattgga attactgtaa acagcctact gaaaatgcat ttttatcatg taacattctt     2954

ctacttgttt aacattgctg attttctctg gcagcataat tttgtggtta agagaatgaa     3014

ttctgaatgt acactttctg tctcaaaccc tggctgtaat ttcagctagt taataattct     3074

ttgtgttcag ttccactatc taggtatttt cttcaaaagg taaatacaat ggtttctgaa     3134

agaatcattt gcattatcag cctgtttggg atgtctgaga tcagtgcctc tgggttgtta     3194

atactgtatt gctgtatggt atatgtatgc tgatttacta cttatgcgta agtggtatgc     3254

atgggatgtc tgaaatcagt gcctatgggt tgtcaatagt attaactatt agtgttaact     3314

gttagtatta actattagta ttattaacac taataatagt actattacta ttactatttt     3374

tattttaaaa taaaatttac ctttaaaata ataatagtac tattgctagt actagtacta     3434

ttgctattac tagtactatt actagtacta gtactatgac actgttaata gtactattaa     3494

caacccatag gcacttggga tgtctgagat cagtgcctat gggttgttaa tactatattg     3554

ctgtatggta tatgcatgct gatttaccac ttatgcatag atatatcttt aataagtaat     3614

ctaaaaatcc tttttgtatt tgagagaatc tactaagttc agtccagtca agaaaagaac     3674

ctaatagcac caatacaaat tgaggactta atttactttg gaatgttgaa ttgcatttgt     3734

tccattaaaa aaaacagaaa tttgcga                                         3761


<210>  13
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu Gln Trp Asp His Phe His Asn Gln Gln Glu Asp Thr Asp Ser 
1               5                   10                  15      


Cys Ser Glu Ser Val Lys Phe Asp Ala Arg Ser Met Thr Ala Leu Leu 
            20                  25                  30          


Pro Pro Asn Pro Lys Asn Ser Pro Ser Leu Gln Glu Lys Leu Lys Ser 
        35                  40                  45              


Phe Lys Ala Ala Leu Ile Ala Leu Tyr Leu Leu Val Phe Ala Val Leu 
    50                  55                  60                  


Ile Pro Leu Ile Gly Ile Val Ala Ala Gln Leu Leu Lys Trp Glu Thr 
65                  70                  75                  80  


Lys Asn Cys Ser Val Ser Ser Thr Asn Ala Asn Asp Ile Thr Gln Ser 
                85                  90                  95      


Leu Thr Gly Lys Gly Asn Asp Ser Glu Glu Glu Met Arg Phe Gln Glu 
            100                 105                 110         


Val Phe Met Glu His Met Ser Asn Met Glu Lys Arg Ile Gln His Ile 
        115                 120                 125             


Leu Asp Met Glu Ala Asn Leu Met Asp Thr Glu His Phe Gln Asn Phe 
    130                 135                 140                 


Ser Met Thr Thr Asp Gln Arg Phe Asn Asp Ile Leu Leu Gln Leu Ser 
145                 150                 155                 160 


Thr Leu Phe Ser Ser Val Gln Gly His Gly Asn Ala Ile Asp Glu Ile 
                165                 170                 175     


Ser Lys Ser Leu Ile Ser Leu Asn Thr Thr Leu Leu Asp Leu Gln Leu 
            180                 185                 190         


Asn Ile Glu Asn Leu Asn Gly Lys Ile Gln Glu Asn Thr Phe Lys Gln 
        195                 200                 205             


Gln Glu Glu Ile Ser Lys Leu Glu Glu Arg Val Tyr Asn Val Ser Ala 
    210                 215                 220                 


Glu Ile Met Ala Met Lys Glu Glu Gln Val His Leu Glu Gln Glu Ile 
225                 230                 235                 240 


Lys Gly Glu Val Lys Val Leu Asn Asn Ile Thr Asn Asp Leu Arg Leu 
                245                 250                 255     


Lys Asp Trp Glu His Ser Gln Thr Leu Arg Asn Ile Thr Leu Ile Gln 
            260                 265                 270         


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Asp Arg Gly Pro Thr Gly 
        275                 280                 285             


Glu Ser Gly Pro Arg Gly Phe Pro Gly Pro Ile Gly Pro Pro Gly Leu 
    290                 295                 300                 


Lys Gly Asp Arg Gly Ala Ile Gly Phe Pro Gly Ser Arg Gly Leu Pro 
305                 310                 315                 320 


Gly Tyr Ala Gly Arg Pro Gly Asn Ser Gly Pro Lys Gly Gln Lys Gly 
                325                 330                 335     


Glu Lys Gly Ser Gly Asn Thr Leu Thr Pro Phe Thr Lys Val Arg Leu 
            340                 345                 350         


Val Gly Gly Ser Gly Pro His Glu Gly Arg Val Glu Ile Leu His Ser 
        355                 360                 365             


Gly Gln Trp Gly Thr Ile Cys Asp Asp Arg Trp Glu Val Arg Val Gly 
    370                 375                 380                 


Gln Val Val Cys Arg Ser Leu Gly Tyr Pro Gly Val Gln Ala Val His 
385                 390                 395                 400 


Lys Ala Ala His Phe Gly Gln Gly Thr Gly Pro Ile Trp Leu Asn Glu 
                405                 410                 415     


Val Phe Cys Phe Gly Arg Glu Ser Ser Ile Glu Glu Cys Lys Ile Arg 
            420                 425                 430         


Gln Trp Gly Thr Arg Ala Cys Ser His Ser Glu Asp Ala Gly Val Thr 
        435                 440                 445             


Cys Thr Leu 
    450     


<210>  14
<211>  1116
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (27)..(773)
<223>  Spic

<400>  14
cagaattgtc aatttattaa tgaaat atg acg tgt gtt gaa caa gac aag ctg        53
                             Met Thr Cys Val Glu Gln Asp Lys Leu          
                             1               5                            

ggt caa gca ttt gaa gat gct ttt gag gtt ctg agg caa cat tca act        101
Gly Gln Ala Phe Glu Asp Ala Phe Glu Val Leu Arg Gln His Ser Thr           
10                  15                  20                  25            

gga gat ctt cag tac tcg cca gat tac aga aat tac ctg gct tta atc        149
Gly Asp Leu Gln Tyr Ser Pro Asp Tyr Arg Asn Tyr Leu Ala Leu Ile           
                30                  35                  40                

aac cat cgt cct cat gtc aaa gga aat tcc agc tgc tat gga gtg ttg        197
Asn His Arg Pro His Val Lys Gly Asn Ser Ser Cys Tyr Gly Val Leu           
            45                  50                  55                    

cct aca gag gag cct gtc tat aat tgg aga acg gta att aac agt gct        245
Pro Thr Glu Glu Pro Val Tyr Asn Trp Arg Thr Val Ile Asn Ser Ala           
        60                  65                  70                        

gcg gac ttc tat ttt gaa gga aat att cat caa tct ctg cag aac ata        293
Ala Asp Phe Tyr Phe Glu Gly Asn Ile His Gln Ser Leu Gln Asn Ile           
    75                  80                  85                            

act gaa aac cag ctg gta caa ccc act ctt ctc cag caa aag ggg gga        341
Thr Glu Asn Gln Leu Val Gln Pro Thr Leu Leu Gln Gln Lys Gly Gly           
90                  95                  100                 105           

aaa ggc agg aag aag ctc cga ctg ttt gaa tac ctt cac gaa tcc ctg        389
Lys Gly Arg Lys Lys Leu Arg Leu Phe Glu Tyr Leu His Glu Ser Leu           
                110                 115                 120               

tat aat ccg gag atg gca tct tgt att cag tgg gta gat aaa acc aaa        437
Tyr Asn Pro Glu Met Ala Ser Cys Ile Gln Trp Val Asp Lys Thr Lys           
            125                 130                 135                   

ggc atc ttt cag ttt gta tca aaa aac aaa gaa aaa ctt gcc gag ctt        485
Gly Ile Phe Gln Phe Val Ser Lys Asn Lys Glu Lys Leu Ala Glu Leu           
        140                 145                 150                       

tgg ggg aaa aga aaa ggc aac agg aag acc atg act tac cag aaa atg        533
Trp Gly Lys Arg Lys Gly Asn Arg Lys Thr Met Thr Tyr Gln Lys Met           
    155                 160                 165                           

gcc agg gca ctc aga aat tac gga aga agt ggg gaa att acc aaa atc        581
Ala Arg Ala Leu Arg Asn Tyr Gly Arg Ser Gly Glu Ile Thr Lys Ile           
170                 175                 180                 185           

cgg agg aag ctg act tac cag ttc agt gag gcc att ctc caa aga ctc        629
Arg Arg Lys Leu Thr Tyr Gln Phe Ser Glu Ala Ile Leu Gln Arg Leu           
                190                 195                 200               

tct cca tcc tat ttc ctg ggg aaa gag atc ttc tat tca cag tgt gtt        677
Ser Pro Ser Tyr Phe Leu Gly Lys Glu Ile Phe Tyr Ser Gln Cys Val           
            205                 210                 215                   

caa cct gat caa gaa tat ctc agt tta aat aac tgg aat gca aat tat        725
Gln Pro Asp Gln Glu Tyr Leu Ser Leu Asn Asn Trp Asn Ala Asn Tyr           
        220                 225                 230                       

aat tat aca tat gcc aat tac cat gag cta aat cac cat gat tgc taa        773
Asn Tyr Thr Tyr Ala Asn Tyr His Glu Leu Asn His His Asp Cys               
    235                 240                 245                           

atatactttc atatttcatg gtttactggc atcggaaatc tctacaagtt ttaatgattt      833

ctccctccct ctcttttttt cctcctctga agaaatttag gatttttctc ttaaagcaaa      893

tactaaagag gaaaaaaaat taactttatt gttgctttta tcaaagagta tgtaatctat      953

actaacttgt tgggaaattc tgccaatgaa caactttttt ataataaaaa aaaaaaaaaa     1013

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1073

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                       1116


<210>  15
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Thr Cys Val Glu Gln Asp Lys Leu Gly Gln Ala Phe Glu Asp Ala 
1               5                   10                  15      


Phe Glu Val Leu Arg Gln His Ser Thr Gly Asp Leu Gln Tyr Ser Pro 
            20                  25                  30          


Asp Tyr Arg Asn Tyr Leu Ala Leu Ile Asn His Arg Pro His Val Lys 
        35                  40                  45              


Gly Asn Ser Ser Cys Tyr Gly Val Leu Pro Thr Glu Glu Pro Val Tyr 
    50                  55                  60                  


Asn Trp Arg Thr Val Ile Asn Ser Ala Ala Asp Phe Tyr Phe Glu Gly 
65                  70                  75                  80  


Asn Ile His Gln Ser Leu Gln Asn Ile Thr Glu Asn Gln Leu Val Gln 
                85                  90                  95      


Pro Thr Leu Leu Gln Gln Lys Gly Gly Lys Gly Arg Lys Lys Leu Arg 
            100                 105                 110         


Leu Phe Glu Tyr Leu His Glu Ser Leu Tyr Asn Pro Glu Met Ala Ser 
        115                 120                 125             


Cys Ile Gln Trp Val Asp Lys Thr Lys Gly Ile Phe Gln Phe Val Ser 
    130                 135                 140                 


Lys Asn Lys Glu Lys Leu Ala Glu Leu Trp Gly Lys Arg Lys Gly Asn 
145                 150                 155                 160 


Arg Lys Thr Met Thr Tyr Gln Lys Met Ala Arg Ala Leu Arg Asn Tyr 
                165                 170                 175     


Gly Arg Ser Gly Glu Ile Thr Lys Ile Arg Arg Lys Leu Thr Tyr Gln 
            180                 185                 190         


Phe Ser Glu Ala Ile Leu Gln Arg Leu Ser Pro Ser Tyr Phe Leu Gly 
        195                 200                 205             


Lys Glu Ile Phe Tyr Ser Gln Cys Val Gln Pro Asp Gln Glu Tyr Leu 
    210                 215                 220                 


Ser Leu Asn Asn Trp Asn Ala Asn Tyr Asn Tyr Thr Tyr Ala Asn Tyr 
225                 230                 235                 240 


His Glu Leu Asn His His Asp Cys 
                245             


<210>  16
<211>  1663
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (264)..(1385)
<223>  Nfe2

<400>  16
gtgcgcctgc ttggggctcc tgtgctcagc tcagcctgag cttccacact cagcgctcag       60

caatggcccg ggggcggggc gcggtcctcg cagattctca aaggtagccg ggatcctcgt      120

ccagcagtgt cagctcaggc tcagcctccc cagagacaac accgggagcc tcatctctct      180

cctcaccctg ctgtgactcc accacaggtt tctagagcca tctgggcttt ccgggaacct      240

ggaccagact ctggcccagt agg atg tcc ccg tgt cct ccc cag cag agc agg      293
                          Met Ser Pro Cys Pro Pro Gln Gln Ser Arg         
                          1               5                   10          

aac agg gtg ata cag ctg tcc act tca gag cta gga gag atg gaa ctg        341
Asn Arg Val Ile Gln Leu Ser Thr Ser Glu Leu Gly Glu Met Glu Leu           
                15                  20                  25                

act tgg cag gag atc atg tcc atc acc gag ctg cag ggt ctg aat gct        389
Thr Trp Gln Glu Ile Met Ser Ile Thr Glu Leu Gln Gly Leu Asn Ala           
            30                  35                  40                    

cca agt gag cca tca ttt gag ccc caa gcc cca gct cca tac ctt gga        437
Pro Ser Glu Pro Ser Phe Glu Pro Gln Ala Pro Ala Pro Tyr Leu Gly           
        45                  50                  55                        

cct cca cca ccc aca act tac tgc ccc tgc tca atc cac cca gat tct        485
Pro Pro Pro Pro Thr Thr Tyr Cys Pro Cys Ser Ile His Pro Asp Ser           
    60                  65                  70                            

ggc ttc cca ctt cct cca cca cct tat gag ctc cca gca tcc aca tcc        533
Gly Phe Pro Leu Pro Pro Pro Pro Tyr Glu Leu Pro Ala Ser Thr Ser           
75                  80                  85                  90            

cat gtc cca gat ccc cca tac tcc tat ggc aac atg gcc ata cca gtc        581
His Val Pro Asp Pro Pro Tyr Ser Tyr Gly Asn Met Ala Ile Pro Val           
                95                  100                 105               

tcc aag cca ctg agc ctc tca ggc ctg ctc agt gag ccg ctc caa gac        629
Ser Lys Pro Leu Ser Leu Ser Gly Leu Leu Ser Glu Pro Leu Gln Asp           
            110                 115                 120                   

ccc tta gcc ctc ctg gac att ggg ctg cca gca ggg cca cct aag ccc        677
Pro Leu Ala Leu Leu Asp Ile Gly Leu Pro Ala Gly Pro Pro Lys Pro           
        125                 130                 135                       

caa gaa gac cca gaa tcc gac tca gga tta tcc ctc aac tat agc gat        725
Gln Glu Asp Pro Glu Ser Asp Ser Gly Leu Ser Leu Asn Tyr Ser Asp           
    140                 145                 150                           

gct gaa tct ctt gag ctg gag ggg aca gag gct ggt cgg cgg cgc agc        773
Ala Glu Ser Leu Glu Leu Glu Gly Thr Glu Ala Gly Arg Arg Arg Ser           
155                 160                 165                 170           

gaa tat gta gag atg tac cca gtg gag tac ccc tac tca ctc atg ccc        821
Glu Tyr Val Glu Met Tyr Pro Val Glu Tyr Pro Tyr Ser Leu Met Pro           
                175                 180                 185               

aac tcc ttg gcc cac tcc aac tat acc ttg cca gct gct gag acc ccc        869
Asn Ser Leu Ala His Ser Asn Tyr Thr Leu Pro Ala Ala Glu Thr Pro           
            190                 195                 200                   

ttg gcc tta gag ccc tcc tca ggc cct gtg cgg gct aag ccc act gca        917
Leu Ala Leu Glu Pro Ser Ser Gly Pro Val Arg Ala Lys Pro Thr Ala           
        205                 210                 215                       

cgg ggg gag gca ggg agt cgg gat gaa cgt cgg gcc ttg gcc atg aag        965
Arg Gly Glu Ala Gly Ser Arg Asp Glu Arg Arg Ala Leu Ala Met Lys           
    220                 225                 230                           

att cct ttt cct acg gac aag att gtc aac ttg ccg gta gat gac ttt       1013
Ile Pro Phe Pro Thr Asp Lys Ile Val Asn Leu Pro Val Asp Asp Phe           
235                 240                 245                 250           

aat gag cta ttg gca agg tac ccg ctg aca gag agc cag cta gcg cta       1061
Asn Glu Leu Leu Ala Arg Tyr Pro Leu Thr Glu Ser Gln Leu Ala Leu           
                255                 260                 265               

gtc cgg gac atc cga cga cgg ggc aaa aac aag gtg gca gcc cag aac       1109
Val Arg Asp Ile Arg Arg Arg Gly Lys Asn Lys Val Ala Ala Gln Asn           
            270                 275                 280                   

tgc cgc aag agg aag ctg gaa acc att gtg cag ctg gag cgg gag ctg       1157
Cys Arg Lys Arg Lys Leu Glu Thr Ile Val Gln Leu Glu Arg Glu Leu           
        285                 290                 295                       

gag cgg ctg acc aat gaa cgg gag cgg ctt ctc agg gcc cgc ggg gag       1205
Glu Arg Leu Thr Asn Glu Arg Glu Arg Leu Leu Arg Ala Arg Gly Glu           
    300                 305                 310                           

gca gac cgg acc ctg gag gtc atg cgc caa cag ctg aca gag ctg tac       1253
Ala Asp Arg Thr Leu Glu Val Met Arg Gln Gln Leu Thr Glu Leu Tyr           
315                 320                 325                 330           

cgt gac att ttc cag cac ctt cgg gat gaa tca ggc aac agc tac tct       1301
Arg Asp Ile Phe Gln His Leu Arg Asp Glu Ser Gly Asn Ser Tyr Ser           
                335                 340                 345               

cct gaa gag tac gcg ctg caa cag gct gcc gat ggg acc atc ttc ctt       1349
Pro Glu Glu Tyr Ala Leu Gln Gln Ala Ala Asp Gly Thr Ile Phe Leu           
            350                 355                 360                   

gtg ccc cgg ggg acc aag atg gag gcc aca gac tga gctggcccag            1395
Val Pro Arg Gly Thr Lys Met Glu Ala Thr Asp                               
        365                 370                                           

aggggtggaa ctgctgatgg gatttccttc attcccttct gataaaggta ctccccaacc     1455

ctgagtccca gaaggagctg agttctctag accagaagag gatgacaatg gcaacaagtg     1515

tttggaagtt ccaaggtgtg ttcaaagagg cttgccttga gggagggctg gaatctgtct     1575

tccctgactc ggctcctcag gtctttagcc tccaccttgt ctaagctttg gtctataaag     1635

tgcgctacag aaaaaaaaaa aaaaaaaa                                        1663


<210>  17
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ser Pro Cys Pro Pro Gln Gln Ser Arg Asn Arg Val Ile Gln Leu 
1               5                   10                  15      


Ser Thr Ser Glu Leu Gly Glu Met Glu Leu Thr Trp Gln Glu Ile Met 
            20                  25                  30          


Ser Ile Thr Glu Leu Gln Gly Leu Asn Ala Pro Ser Glu Pro Ser Phe 
        35                  40                  45              


Glu Pro Gln Ala Pro Ala Pro Tyr Leu Gly Pro Pro Pro Pro Thr Thr 
    50                  55                  60                  


Tyr Cys Pro Cys Ser Ile His Pro Asp Ser Gly Phe Pro Leu Pro Pro 
65                  70                  75                  80  


Pro Pro Tyr Glu Leu Pro Ala Ser Thr Ser His Val Pro Asp Pro Pro 
                85                  90                  95      


Tyr Ser Tyr Gly Asn Met Ala Ile Pro Val Ser Lys Pro Leu Ser Leu 
            100                 105                 110         


Ser Gly Leu Leu Ser Glu Pro Leu Gln Asp Pro Leu Ala Leu Leu Asp 
        115                 120                 125             


Ile Gly Leu Pro Ala Gly Pro Pro Lys Pro Gln Glu Asp Pro Glu Ser 
    130                 135                 140                 


Asp Ser Gly Leu Ser Leu Asn Tyr Ser Asp Ala Glu Ser Leu Glu Leu 
145                 150                 155                 160 


Glu Gly Thr Glu Ala Gly Arg Arg Arg Ser Glu Tyr Val Glu Met Tyr 
                165                 170                 175     


Pro Val Glu Tyr Pro Tyr Ser Leu Met Pro Asn Ser Leu Ala His Ser 
            180                 185                 190         


Asn Tyr Thr Leu Pro Ala Ala Glu Thr Pro Leu Ala Leu Glu Pro Ser 
        195                 200                 205             


Ser Gly Pro Val Arg Ala Lys Pro Thr Ala Arg Gly Glu Ala Gly Ser 
    210                 215                 220                 


Arg Asp Glu Arg Arg Ala Leu Ala Met Lys Ile Pro Phe Pro Thr Asp 
225                 230                 235                 240 


Lys Ile Val Asn Leu Pro Val Asp Asp Phe Asn Glu Leu Leu Ala Arg 
                245                 250                 255     


Tyr Pro Leu Thr Glu Ser Gln Leu Ala Leu Val Arg Asp Ile Arg Arg 
            260                 265                 270         


Arg Gly Lys Asn Lys Val Ala Ala Gln Asn Cys Arg Lys Arg Lys Leu 
        275                 280                 285             


Glu Thr Ile Val Gln Leu Glu Arg Glu Leu Glu Arg Leu Thr Asn Glu 
    290                 295                 300                 


Arg Glu Arg Leu Leu Arg Ala Arg Gly Glu Ala Asp Arg Thr Leu Glu 
305                 310                 315                 320 


Val Met Arg Gln Gln Leu Thr Glu Leu Tyr Arg Asp Ile Phe Gln His 
                325                 330                 335     


Leu Arg Asp Glu Ser Gly Asn Ser Tyr Ser Pro Glu Glu Tyr Ala Leu 
            340                 345                 350         


Gln Gln Ala Ala Asp Gly Thr Ile Phe Leu Val Pro Arg Gly Thr Lys 
        355                 360                 365             


Met Glu Ala Thr Asp 
    370             


<210>  18
<211>  1248
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (127)..(681)
<223>  Tnfaip8l2

<400>  18
ggccaagcca aagggctctc acactaagtg aagcttctcc attctgtaag ctttccggga       60

acatccaagg caagactggc acccagcaca gcagtgactg accacatacc ccactctcca      120

ggaccc atg gag tcc ttc agc tca aag agc ctg gca ctg caa gca gag         168
       Met Glu Ser Phe Ser Ser Lys Ser Leu Ala Leu Gln Ala Glu            
       1               5                   10                             

aag aag cta ctg agt aag atg gcg ggt cgc tct gtg gct cat ctc ttc        216
Lys Lys Leu Leu Ser Lys Met Ala Gly Arg Ser Val Ala His Leu Phe           
15                  20                  25                  30            

ata gat gag aca agc agt gag gtg cta gat gag ctc tac cgt gtg tcc        264
Ile Asp Glu Thr Ser Ser Glu Val Leu Asp Glu Leu Tyr Arg Val Ser           
                35                  40                  45                

aag gag tac acg cac agc cgg ccc cag gcc cag cgc gtg atc aag gac        312
Lys Glu Tyr Thr His Ser Arg Pro Gln Ala Gln Arg Val Ile Lys Asp           
            50                  55                  60                    

ctg atc aaa gtg gcc atc aag gtg gct gtg ctg cac cgc aat ggc tcc        360
Leu Ile Lys Val Ala Ile Lys Val Ala Val Leu His Arg Asn Gly Ser           
        65                  70                  75                        

ttt ggc ccc agt gag ctg gcc ctg gct acc cgc ttt cgc cag aag ctg        408
Phe Gly Pro Ser Glu Leu Ala Leu Ala Thr Arg Phe Arg Gln Lys Leu           
    80                  85                  90                            

cgg cag ggt gcc atg acg gca ctt agc ttt ggt gag gta gac ttc acc        456
Arg Gln Gly Ala Met Thr Ala Leu Ser Phe Gly Glu Val Asp Phe Thr           
95                  100                 105                 110           

ttc gag gct gct gtt ctg gct ggc ctg ctg acc gag tgc cgg gat gtg        504
Phe Glu Ala Ala Val Leu Ala Gly Leu Leu Thr Glu Cys Arg Asp Val           
                115                 120                 125               

ctg cta gag ttg gtg gaa cac cac ctc acg ccc aag tca cat ggc cgc        552
Leu Leu Glu Leu Val Glu His His Leu Thr Pro Lys Ser His Gly Arg           
            130                 135                 140                   

atc cgc cac gtg ttt gat cac ttc tct gac cca ggt ctg ctc acg gcc        600
Ile Arg His Val Phe Asp His Phe Ser Asp Pro Gly Leu Leu Thr Ala           
        145                 150                 155                       

ctc tat ggg cct gac ttc act cag cac ctt ggc aag atc tgt gac gga        648
Leu Tyr Gly Pro Asp Phe Thr Gln His Leu Gly Lys Ile Cys Asp Gly           
    160                 165                 170                           

ctc agg aag ctg cta gac gaa ggg aag ctc tga gagccctgag cctagcacat      701
Leu Arg Lys Leu Leu Asp Glu Gly Lys Leu                                   
175                 180                                                   

tccaccttga caaaatggtt gactgagaaa acacagataa tgggcttcct aaccctgctc      761

acctggcact aacacttttc aatcttcagg cttcattcct tcccaagagt gcttttgact      821

ctgagaccag cccaccccca aacagctagt ggagaaggag caatgctgag gggtgaggcc      881

tctctcccac tccagcccca ggacaggaaa cagaactgcc tgaaaaaggt gaagtgaaac      941

ttggatctct atttctccca taagggactt ctgaaacagg gaagccccct cccatgtgaa     1001

ccaaggaaag gaggcacagc ccagagaacc cctttgggga tactaaagac agaagagggg     1061

aaggtggccc ttagagacag agcttggaca gatgccagag gctctgttcc agagtgcagg     1121

aagaaggggc tagggcaggg gagattctca taggggaaat aaaactacta aaatatgaaa     1181

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1241

aaaaaaa                                                               1248


<210>  19
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Glu Ser Phe Ser Ser Lys Ser Leu Ala Leu Gln Ala Glu Lys Lys 
1               5                   10                  15      


Leu Leu Ser Lys Met Ala Gly Arg Ser Val Ala His Leu Phe Ile Asp 
            20                  25                  30          


Glu Thr Ser Ser Glu Val Leu Asp Glu Leu Tyr Arg Val Ser Lys Glu 
        35                  40                  45              


Tyr Thr His Ser Arg Pro Gln Ala Gln Arg Val Ile Lys Asp Leu Ile 
    50                  55                  60                  


Lys Val Ala Ile Lys Val Ala Val Leu His Arg Asn Gly Ser Phe Gly 
65                  70                  75                  80  


Pro Ser Glu Leu Ala Leu Ala Thr Arg Phe Arg Gln Lys Leu Arg Gln 
                85                  90                  95      


Gly Ala Met Thr Ala Leu Ser Phe Gly Glu Val Asp Phe Thr Phe Glu 
            100                 105                 110         


Ala Ala Val Leu Ala Gly Leu Leu Thr Glu Cys Arg Asp Val Leu Leu 
        115                 120                 125             


Glu Leu Val Glu His His Leu Thr Pro Lys Ser His Gly Arg Ile Arg 
    130                 135                 140                 


His Val Phe Asp His Phe Ser Asp Pro Gly Leu Leu Thr Ala Leu Tyr 
145                 150                 155                 160 


Gly Pro Asp Phe Thr Gln His Leu Gly Lys Ile Cys Asp Gly Leu Arg 
                165                 170                 175     


Lys Leu Leu Asp Glu Gly Lys Leu 
            180                 


<210>  20
<211>  1254
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (33)..(503)
<223>  Ier3

<400>  20
ctcacttggc cttacactcc gctcggctca cc atg tgt cac tct cgc agc tgc         53
                                    Met Cys His Ser Arg Ser Cys           
                                    1               5                     

cac ccg acc atg acc atc ctg cag gcc ccg acc ccg gcc ccc tcc acc        101
His Pro Thr Met Thr Ile Leu Gln Ala Pro Thr Pro Ala Pro Ser Thr           
        10                  15                  20                        

atc ccg gga ccc cgg cgg ggc tcc ggt cct gag atc ttc acc ttc gac        149
Ile Pro Gly Pro Arg Arg Gly Ser Gly Pro Glu Ile Phe Thr Phe Asp           
    25                  30                  35                            

cct ctc ccg gag ccc gca gcg gcc cct gcc ggg cgc ccc agc gcc tct        197
Pro Leu Pro Glu Pro Ala Ala Ala Pro Ala Gly Arg Pro Ser Ala Ser           
40                  45                  50                  55            

cgc ggg cac cga aag cgc agc cgc agg gtt ctc tac cct cga gtg gtc        245
Arg Gly His Arg Lys Arg Ser Arg Arg Val Leu Tyr Pro Arg Val Val           
                60                  65                  70                

cgg cgc cag ctg cca gtc gag gaa ccg aac cca gcc aaa agg ctt ctc        293
Arg Arg Gln Leu Pro Val Glu Glu Pro Asn Pro Ala Lys Arg Leu Leu           
            75                  80                  85                    

ttt ctg ctg ctc acc atc gtc ttc tgc cag atc ctg atg gct gaa gag        341
Phe Leu Leu Leu Thr Ile Val Phe Cys Gln Ile Leu Met Ala Glu Glu           
        90                  95                  100                       

ggt gtg ccg gcg ccc ctg cct cca gag gac gcc cct aac gcc gca tcc        389
Gly Val Pro Ala Pro Leu Pro Pro Glu Asp Ala Pro Asn Ala Ala Ser           
    105                 110                 115                           

ctg gcg ccc acc cct gtg tcc gcc gtc ctc gag ccc ttt aat ctg act        437
Leu Ala Pro Thr Pro Val Ser Ala Val Leu Glu Pro Phe Asn Leu Thr           
120                 125                 130                 135           

tcg gag ccc tcg gac tac gct ctg gac ctc agc act ttc ctc cag caa        485
Ser Glu Pro Ser Asp Tyr Ala Leu Asp Leu Ser Thr Phe Leu Gln Gln           
                140                 145                 150               

cac ccg gcc gcc ttc taa ctgtgactcc ccgcactccc caaaaagaat               533
His Pro Ala Ala Phe                                                       
            155                                                           

ccgaaaaacc acaaagaaac accaggcgta cctggtgcgc gagagcgtat ccccaactgg      593

gacttccgag gcaacttgaa ctcagaacac tacagcggag acgccacccg gtgcttgagg      653

cgggaccgag gcgcacagag accgaggcgc atagagaccg aggcacagcc cagctggggc      713

taggcccggt gggaaggaga gcgtcgttaa tttatttctt attgctccta attaatattt      773

atatgtattt atgtacgtcc tcctaggtga tggagatgtg tacgtaatat ttattttaac      833

ttatgcaagg gtgtgagatg ttccccctgc tgtaaatgca ggtctcttgg tatttattga      893

gctttgtggg actggtggaa gcaggacacc tggaactgcg gcaaagtagg agaagaaatg      953

gggaggactc gggtggggga ggacgtcccg gctgggatga agtctggtgg tgggtcgtaa     1013

gtttaggagg tgactgcatc ctccagcatc tcaactccgt ctgtctactg tgtgagactt     1073

cggcggacca ttaggaatga gatccgtgag atccttccat cttcttgaag tcgcctttag     1133

ggtggctgcg aggtagaggg ttgggggttg gtgggctgtc acggagcgac tgtcgagatc     1193

gcctagtatg ttctgtgaac acaaataaaa ttgatttact gtctgcaaaa aaaaaaaaaa     1253

a                                                                     1254


<210>  21
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Cys His Ser Arg Ser Cys His Pro Thr Met Thr Ile Leu Gln Ala 
1               5                   10                  15      


Pro Thr Pro Ala Pro Ser Thr Ile Pro Gly Pro Arg Arg Gly Ser Gly 
            20                  25                  30          


Pro Glu Ile Phe Thr Phe Asp Pro Leu Pro Glu Pro Ala Ala Ala Pro 
        35                  40                  45              


Ala Gly Arg Pro Ser Ala Ser Arg Gly His Arg Lys Arg Ser Arg Arg 
    50                  55                  60                  


Val Leu Tyr Pro Arg Val Val Arg Arg Gln Leu Pro Val Glu Glu Pro 
65                  70                  75                  80  


Asn Pro Ala Lys Arg Leu Leu Phe Leu Leu Leu Thr Ile Val Phe Cys 
                85                  90                  95      


Gln Ile Leu Met Ala Glu Glu Gly Val Pro Ala Pro Leu Pro Pro Glu 
            100                 105                 110         


Asp Ala Pro Asn Ala Ala Ser Leu Ala Pro Thr Pro Val Ser Ala Val 
        115                 120                 125             


Leu Glu Pro Phe Asn Leu Thr Ser Glu Pro Ser Asp Tyr Ala Leu Asp 
    130                 135                 140                 


Leu Ser Thr Phe Leu Gln Gln His Pro Ala Ala Phe 
145                 150                 155     


<210>  22
<211>  4817
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (129)..(2546)
<223>  Pik3ap1

<400>  22
gaagcgccag agcggcggcc ggtcccgcgc ggagcccggc gcccctccag cccgagccag       60

gacgccgccg gccccggtcc cggccccggg cacgcagcga gccagggatg tgagcggcgc      120

cccgcggc atg gca gcc tca ggg gtg ccc aga gga tgc gac atc ctc atc       170
         Met Ala Ala Ser Gly Val Pro Arg Gly Cys Asp Ile Leu Ile          
         1               5                   10                           

gtc tac agc ccg gat gcc gag gaa tgg tgc cag tac ctg cag acc ctg        218
Val Tyr Ser Pro Asp Ala Glu Glu Trp Cys Gln Tyr Leu Gln Thr Leu           
15                  20                  25                  30            

ttc ctg tcc agt cgg cag gtc cgc agc cag aag ata ctg act cac agg        266
Phe Leu Ser Ser Arg Gln Val Arg Ser Gln Lys Ile Leu Thr His Arg           
                35                  40                  45                

ctg ggc ccc gag gcc tcc ttc tcg gca gag gac cta agc ctt ttc ctc        314
Leu Gly Pro Glu Ala Ser Phe Ser Ala Glu Asp Leu Ser Leu Phe Leu           
            50                  55                  60                    

agc acc cgc tgt gtc gtg gtg ctg ctg tcc gcg gag ctg gtg cag cac        362
Ser Thr Arg Cys Val Val Val Leu Leu Ser Ala Glu Leu Val Gln His           
        65                  70                  75                        

ttc cac aag ccc gcc ttg ctg ccc ctg ctg cag aga gct ttc cat cct        410
Phe His Lys Pro Ala Leu Leu Pro Leu Leu Gln Arg Ala Phe His Pro           
    80                  85                  90                            

ccg cac cgc gtg gtc agg ctg ctc tgc ggc gtg cgg gac agc gag gag        458
Pro His Arg Val Val Arg Leu Leu Cys Gly Val Arg Asp Ser Glu Glu           
95                  100                 105                 110           

ttc cta gac ttc ttt cca gat tgg gcc cat tgg cag gag ctc acc tgt        506
Phe Leu Asp Phe Phe Pro Asp Trp Ala His Trp Gln Glu Leu Thr Cys           
                115                 120                 125               

gac gat gag cca gag acc tac gtg gca gct gtg aaa aaa gcc att tcc        554
Asp Asp Glu Pro Glu Thr Tyr Val Ala Ala Val Lys Lys Ala Ile Ser           
            130                 135                 140                   

gaa gat tct ggc tgt gac tca gtc act gac act gag cct gag gac gag        602
Glu Asp Ser Gly Cys Asp Ser Val Thr Asp Thr Glu Pro Glu Asp Glu           
        145                 150                 155                       

aag gtt gtt tcc tac tcg aag cag cag aac ctg ccg acg gtg act tca        650
Lys Val Val Ser Tyr Ser Lys Gln Gln Asn Leu Pro Thr Val Thr Ser           
    160                 165                 170                           

cct ggg aac ctg atg gtg gtg cag ccg gac cgc att cgc tgt ggg gca        698
Pro Gly Asn Leu Met Val Val Gln Pro Asp Arg Ile Arg Cys Gly Ala           
175                 180                 185                 190           

gaa acc act gtc tat gtt att gtg aga tgt aag ctg gat gac agg gtg        746
Glu Thr Thr Val Tyr Val Ile Val Arg Cys Lys Leu Asp Asp Arg Val           
                195                 200                 205               

gcg aca gaa gca gag ttt tct cct gag gat tct ccc tct gta agg atg        794
Ala Thr Glu Ala Glu Phe Ser Pro Glu Asp Ser Pro Ser Val Arg Met           
            210                 215                 220                   

gaa gcc aag gtg gag aat gag tac acc att tca gtg aag gct ccc aac        842
Glu Ala Lys Val Glu Asn Glu Tyr Thr Ile Ser Val Lys Ala Pro Asn           
        225                 230                 235                       

ctt tca tct ggg aac gtt tct ctg aag ata tat tct gga gac tta gtg        890
Leu Ser Ser Gly Asn Val Ser Leu Lys Ile Tyr Ser Gly Asp Leu Val           
    240                 245                 250                           

gtg tgt gaa acc gtt atc agc tat tat act gac atg gaa gaa att ggg        938
Val Cys Glu Thr Val Ile Ser Tyr Tyr Thr Asp Met Glu Glu Ile Gly           
255                 260                 265                 270           

aat tta ttg tcc aat gcc gcg aat cct gtg gaa ttc atg tgt cag gcc        986
Asn Leu Leu Ser Asn Ala Ala Asn Pro Val Glu Phe Met Cys Gln Ala           
                275                 280                 285               

ttt aaa att gtg ccc tac aac aca gag acc ctt gat aaa ctg cta acc       1034
Phe Lys Ile Val Pro Tyr Asn Thr Glu Thr Leu Asp Lys Leu Leu Thr           
            290                 295                 300                   

gaa tcc ctg aag aac aat atc cct gca agc gga ctg cac ctc ttt gga       1082
Glu Ser Leu Lys Asn Asn Ile Pro Ala Ser Gly Leu His Leu Phe Gly           
        305                 310                 315                       

atc aac cag ctg gaa gaa gaa gat atg atg aca aat cag agg gat gaa       1130
Ile Asn Gln Leu Glu Glu Glu Asp Met Met Thr Asn Gln Arg Asp Glu           
    320                 325                 330                           

gag ctg ccc acc ctg ttg cat ttt gct gcg aag tat gga ctg aag aac       1178
Glu Leu Pro Thr Leu Leu His Phe Ala Ala Lys Tyr Gly Leu Lys Asn           
335                 340                 345                 350           

ctc act gcc ttg ttg ctc acc tgc cca gga gcc ctg cag gcg tac agc       1226
Leu Thr Ala Leu Leu Leu Thr Cys Pro Gly Ala Leu Gln Ala Tyr Ser           
                355                 360                 365               

gtg gcc aac aag cat ggc cac tac ccc aac acc atc gct gag aaa cac       1274
Val Ala Asn Lys His Gly His Tyr Pro Asn Thr Ile Ala Glu Lys His           
            370                 375                 380                   

ggc ttc agg gac ctg cgg cag ttc atc gac gag tat gtg gaa acg gtg       1322
Gly Phe Arg Asp Leu Arg Gln Phe Ile Asp Glu Tyr Val Glu Thr Val           
        385                 390                 395                       

gac atg ctc aag agt cac att aaa gag gaa ctg atg cac ggg gag gag       1370
Asp Met Leu Lys Ser His Ile Lys Glu Glu Leu Met His Gly Glu Glu           
    400                 405                 410                           

gct gat gct gtg tac gag tcc atg gcc cac ctt tcc aca gac ctg ctt       1418
Ala Asp Ala Val Tyr Glu Ser Met Ala His Leu Ser Thr Asp Leu Leu           
415                 420                 425                 430           

atg aaa tgc tcg ctc aac ccc ggc tgt gac gag gat ctc tat gag tcc       1466
Met Lys Cys Ser Leu Asn Pro Gly Cys Asp Glu Asp Leu Tyr Glu Ser           
                435                 440                 445               

atg gct gcc ttt gtc cca gct gcc act gaa gac ctc tat gtt gaa atg       1514
Met Ala Ala Phe Val Pro Ala Ala Thr Glu Asp Leu Tyr Val Glu Met           
            450                 455                 460                   

ctt cag gcc agt aca tct aac cca atc cct gga gat ggt ttc tct cgg       1562
Leu Gln Ala Ser Thr Ser Asn Pro Ile Pro Gly Asp Gly Phe Ser Arg           
        465                 470                 475                       

gcc act aag gac tct atg atc cgc aag ttt tta gaa ggc aac agc atg       1610
Ala Thr Lys Asp Ser Met Ile Arg Lys Phe Leu Glu Gly Asn Ser Met           
    480                 485                 490                           

gga atg acc aat ctg gag aga gat cag tgc cat ctt ggt cag gaa gaa       1658
Gly Met Thr Asn Leu Glu Arg Asp Gln Cys His Leu Gly Gln Glu Glu           
495                 500                 505                 510           

gat gtt tat cac acg gtg gat gac gat gag gcc ttt tct gtg gac ctg       1706
Asp Val Tyr His Thr Val Asp Asp Asp Glu Ala Phe Ser Val Asp Leu           
                515                 520                 525               

gcc agc agg ccc cct gtc cca gtg ccc aga cca gag acc act gct cct       1754
Ala Ser Arg Pro Pro Val Pro Val Pro Arg Pro Glu Thr Thr Ala Pro           
            530                 535                 540                   

ggt gct cac cag ctg cct gac aac gaa cca tac att ttt aaa gtt ttt       1802
Gly Ala His Gln Leu Pro Asp Asn Glu Pro Tyr Ile Phe Lys Val Phe           
        545                 550                 555                       

gca gaa aaa agt caa gag cgg cct ggg aat ttc tac gtt tcc tca gag       1850
Ala Glu Lys Ser Gln Glu Arg Pro Gly Asn Phe Tyr Val Ser Ser Glu           
    560                 565                 570                           

agc atc agg aaa ggg ccg ccc gtc aga cca tgg agg gac agg ccc cag       1898
Ser Ile Arg Lys Gly Pro Pro Val Arg Pro Trp Arg Asp Arg Pro Gln           
575                 580                 585                 590           

tcg agt ata tat gac cct ttt gcg gga atg aaa acg cca ggc cag cgg       1946
Ser Ser Ile Tyr Asp Pro Phe Ala Gly Met Lys Thr Pro Gly Gln Arg           
                595                 600                 605               

cag ctt atc acc ctc cag gag cag gtg aag ctg ggc att gtc aac gtg       1994
Gln Leu Ile Thr Leu Gln Glu Gln Val Lys Leu Gly Ile Val Asn Val           
            610                 615                 620                   

gat gag gct gtg ctc cac ttc aaa gag tgg cag ctc aac cag aag aaa       2042
Asp Glu Ala Val Leu His Phe Lys Glu Trp Gln Leu Asn Gln Lys Lys           
        625                 630                 635                       

cga tcg gag tcc ttt cgt ttc cag cag gaa aat ctt aaa cgg cta aga       2090
Arg Ser Glu Ser Phe Arg Phe Gln Gln Glu Asn Leu Lys Arg Leu Arg           
    640                 645                 650                           

gac agc atc acc cga aga cag aga gag aag caa aaa tca gga aag cag       2138
Asp Ser Ile Thr Arg Arg Gln Arg Glu Lys Gln Lys Ser Gly Lys Gln           
655                 660                 665                 670           

aca gac ttg gag atc acg gtc cca att cgg cac tca cag cac ctg cct       2186
Thr Asp Leu Glu Ile Thr Val Pro Ile Arg His Ser Gln His Leu Pro           
                675                 680                 685               

gca aaa gtg gag ttt gga gtc tat gag agt ggc ccc agg aaa agt gtc       2234
Ala Lys Val Glu Phe Gly Val Tyr Glu Ser Gly Pro Arg Lys Ser Val           
            690                 695                 700                   

att ccc cct agg acg gag ctg aga cga gga gac tgg aaa aca gac agc       2282
Ile Pro Pro Arg Thr Glu Leu Arg Arg Gly Asp Trp Lys Thr Asp Ser           
        705                 710                 715                       

acc tcc agc aca gca agt agc aca agt aac cgc tcc agc acc cgg agc       2330
Thr Ser Ser Thr Ala Ser Ser Thr Ser Asn Arg Ser Ser Thr Arg Ser           
    720                 725                 730                           

ctc ctc agt gtg agc agc ggg atg gaa ggg gac aac gag gat aat gaa       2378
Leu Leu Ser Val Ser Ser Gly Met Glu Gly Asp Asn Glu Asp Asn Glu           
735                 740                 745                 750           

gtc cct gag gtt acc aga agt cgc agt cca ggc ccc cca caa gtg gat       2426
Val Pro Glu Val Thr Arg Ser Arg Ser Pro Gly Pro Pro Gln Val Asp           
                755                 760                 765               

ggg aca ccc acc atg tcc ctc gag aga ccc ccc agg gtg cct ccg aga       2474
Gly Thr Pro Thr Met Ser Leu Glu Arg Pro Pro Arg Val Pro Pro Arg           
            770                 775                 780                   

gct gcc tca cag agg cct ccg acc agg gag acc ttc cat cct cct cca       2522
Ala Ala Ser Gln Arg Pro Pro Thr Arg Glu Thr Phe His Pro Pro Pro           
        785                 790                 795                       

cct gtt cca ccc aga gga cgc tga ttccacctcc taaaacctgc ctacttcagg      2576
Pro Val Pro Pro Arg Gly Arg                                               
    800                 805                                               

actttaagac tcacagtctt cagcctgtta atgatgtctt catgttgagt tttatagcat     2636

gactgttgac cttaagatcc attctcattg ctgataatgc tgcagccctg ctggtttggg     2696

cttgcctcga agattttatt aaggcacgaa gaagtgaaaa actaagggct tcattcacca     2756

tcaccaagta tatcgaacca tatacttgtt tgccaaaagg atgaagactt aatcgaaata     2816

cttacctcta atttgccata tcagaagcct aaaaagaatg atcataaatg tacttcacca     2876

gtgattttac tgaaatgcac ttatattagt ctttatgtat ttgctagttc agcctgattt     2936

ctagaagagg ttatagtgtg agacttgtag tattcaagta agataagtga cctaatttta     2996

aaataattct tctacttttc tgtatattca gcagggtatt taagtgctag ggctggtcac     3056

acacaaccaa ctgaaaaaga ctagagggat tagtacaaac tcctcttata cagaaggcaa     3116

atctgaggtt ccacagaagt ctggaaccaa gactattcag ttggttaaat aaagaggtta     3176

gtctagactg ggcctgctca ttctaggtca ccacattttc catctccaaa tagccaggcc     3236

ctctctccct caagaaatgc ccagatgtag aaattcatca gtgcctattg gtcttccaga     3296

attttccatc ttccgtatct cccaggcatg agactaccaa gtttgtttgt tttctttcca     3356

atttgggaat ttatacttca gtatggtttc aacgcagtta tgtttccaga gaacatctag     3416

aagtggctgg aaaccagaag ctggggattc cagggacccc acttagtgct ctatttcctt     3476

tataggtttt atttctggtc atagagagag aaggaccttt gactttttct tcgttgaggc     3536

ttctgaggag gaaaaacaaa cctaaaatag aaatacagtc agcctttcaa atccatgggt     3596

tctgtgtccg tggattcaac caaccttgga tcaaaaatat ttgaaaaaaa atctacaaag     3656

tttcaaaaag caaaacttga atttgctgca tgccaagaag tatgttgaat tcatgtaaat     3716

gaagtgatgt gtaggcattg tattagatat tataagaaat ctagaaatga tttaaagcat     3776

acaggaggat gtgcataggt tatatgcaaa tactatgcta ttttatatat gggacttgag     3836

catttgtgga ttttgatact gggggatcct ggaaccaatc ccccatggat accaaagtac     3896

gactgtagtt atctattttt tacatactta ttattaccac catgctcagt aagtccattt     3956

ttgcatggaa tatggagcct taaaacatgt catgaatttg gagtccctgg cacataaatc     4016

taccttcaaa tcagaggtcc ttaatgatgc ctaaacatac agtaaaatta gaatcagaaa     4076

tacttcttta aaaaatattc aaaatgtgtt tgtttcccat gggattattc tctatcccac     4136

acgaatgtaa aaaaatccac attaatgatc catttaagta tagttttatt gggtcctttt     4196

ctaatgatta aaggttcttt ctcaatttca ttcctcagtc ctgcaagtaa ggactcatac     4256

tgaagagtac tgaaacaagg acttcttgtc agaaacagct tctggaatct tgggttttgt     4316

ttttgttttt tgacaaaata cactattggc catgtccatc acgagagtgt ttgtagtaat     4376

taattacctt gtacaggacc tggcacttag tagcattctt caaatgttcc ctcagtgatc     4436

cttttactct ccttgtcact tatttgggag aaataggggc acgtgagata agaagaagaa     4496

taattttgat gttggtatgc ttgccctgtt acttatagac agtctttgtc ataggcaaac     4556

ttgaatttga tttaaaatag ggctgggaaa aatattcaat aactgtaagc ccccttttgg     4616

atgccaaact tagaattttg tacattctct gatgaacaag catttagatc gtaacatggt     4676

aaagcctatt accagccaat gttgttagca tctttgtatg cacatcactg tttgtgcaat     4736

atatgaatat tttgttgcat tgtattctta tataaaaata agtagaaaac ataaaattga     4796

aattgctgat gagaaaaaaa a                                               4817


<210>  23
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Ala Ser Gly Val Pro Arg Gly Cys Asp Ile Leu Ile Val Tyr 
1               5                   10                  15      


Ser Pro Asp Ala Glu Glu Trp Cys Gln Tyr Leu Gln Thr Leu Phe Leu 
            20                  25                  30          


Ser Ser Arg Gln Val Arg Ser Gln Lys Ile Leu Thr His Arg Leu Gly 
        35                  40                  45              


Pro Glu Ala Ser Phe Ser Ala Glu Asp Leu Ser Leu Phe Leu Ser Thr 
    50                  55                  60                  


Arg Cys Val Val Val Leu Leu Ser Ala Glu Leu Val Gln His Phe His 
65                  70                  75                  80  


Lys Pro Ala Leu Leu Pro Leu Leu Gln Arg Ala Phe His Pro Pro His 
                85                  90                  95      


Arg Val Val Arg Leu Leu Cys Gly Val Arg Asp Ser Glu Glu Phe Leu 
            100                 105                 110         


Asp Phe Phe Pro Asp Trp Ala His Trp Gln Glu Leu Thr Cys Asp Asp 
        115                 120                 125             


Glu Pro Glu Thr Tyr Val Ala Ala Val Lys Lys Ala Ile Ser Glu Asp 
    130                 135                 140                 


Ser Gly Cys Asp Ser Val Thr Asp Thr Glu Pro Glu Asp Glu Lys Val 
145                 150                 155                 160 


Val Ser Tyr Ser Lys Gln Gln Asn Leu Pro Thr Val Thr Ser Pro Gly 
                165                 170                 175     


Asn Leu Met Val Val Gln Pro Asp Arg Ile Arg Cys Gly Ala Glu Thr 
            180                 185                 190         


Thr Val Tyr Val Ile Val Arg Cys Lys Leu Asp Asp Arg Val Ala Thr 
        195                 200                 205             


Glu Ala Glu Phe Ser Pro Glu Asp Ser Pro Ser Val Arg Met Glu Ala 
    210                 215                 220                 


Lys Val Glu Asn Glu Tyr Thr Ile Ser Val Lys Ala Pro Asn Leu Ser 
225                 230                 235                 240 


Ser Gly Asn Val Ser Leu Lys Ile Tyr Ser Gly Asp Leu Val Val Cys 
                245                 250                 255     


Glu Thr Val Ile Ser Tyr Tyr Thr Asp Met Glu Glu Ile Gly Asn Leu 
            260                 265                 270         


Leu Ser Asn Ala Ala Asn Pro Val Glu Phe Met Cys Gln Ala Phe Lys 
        275                 280                 285             


Ile Val Pro Tyr Asn Thr Glu Thr Leu Asp Lys Leu Leu Thr Glu Ser 
    290                 295                 300                 


Leu Lys Asn Asn Ile Pro Ala Ser Gly Leu His Leu Phe Gly Ile Asn 
305                 310                 315                 320 


Gln Leu Glu Glu Glu Asp Met Met Thr Asn Gln Arg Asp Glu Glu Leu 
                325                 330                 335     


Pro Thr Leu Leu His Phe Ala Ala Lys Tyr Gly Leu Lys Asn Leu Thr 
            340                 345                 350         


Ala Leu Leu Leu Thr Cys Pro Gly Ala Leu Gln Ala Tyr Ser Val Ala 
        355                 360                 365             


Asn Lys His Gly His Tyr Pro Asn Thr Ile Ala Glu Lys His Gly Phe 
    370                 375                 380                 


Arg Asp Leu Arg Gln Phe Ile Asp Glu Tyr Val Glu Thr Val Asp Met 
385                 390                 395                 400 


Leu Lys Ser His Ile Lys Glu Glu Leu Met His Gly Glu Glu Ala Asp 
                405                 410                 415     


Ala Val Tyr Glu Ser Met Ala His Leu Ser Thr Asp Leu Leu Met Lys 
            420                 425                 430         


Cys Ser Leu Asn Pro Gly Cys Asp Glu Asp Leu Tyr Glu Ser Met Ala 
        435                 440                 445             


Ala Phe Val Pro Ala Ala Thr Glu Asp Leu Tyr Val Glu Met Leu Gln 
    450                 455                 460                 


Ala Ser Thr Ser Asn Pro Ile Pro Gly Asp Gly Phe Ser Arg Ala Thr 
465                 470                 475                 480 


Lys Asp Ser Met Ile Arg Lys Phe Leu Glu Gly Asn Ser Met Gly Met 
                485                 490                 495     


Thr Asn Leu Glu Arg Asp Gln Cys His Leu Gly Gln Glu Glu Asp Val 
            500                 505                 510         


Tyr His Thr Val Asp Asp Asp Glu Ala Phe Ser Val Asp Leu Ala Ser 
        515                 520                 525             


Arg Pro Pro Val Pro Val Pro Arg Pro Glu Thr Thr Ala Pro Gly Ala 
    530                 535                 540                 


His Gln Leu Pro Asp Asn Glu Pro Tyr Ile Phe Lys Val Phe Ala Glu 
545                 550                 555                 560 


Lys Ser Gln Glu Arg Pro Gly Asn Phe Tyr Val Ser Ser Glu Ser Ile 
                565                 570                 575     


Arg Lys Gly Pro Pro Val Arg Pro Trp Arg Asp Arg Pro Gln Ser Ser 
            580                 585                 590         


Ile Tyr Asp Pro Phe Ala Gly Met Lys Thr Pro Gly Gln Arg Gln Leu 
        595                 600                 605             


Ile Thr Leu Gln Glu Gln Val Lys Leu Gly Ile Val Asn Val Asp Glu 
    610                 615                 620                 


Ala Val Leu His Phe Lys Glu Trp Gln Leu Asn Gln Lys Lys Arg Ser 
625                 630                 635                 640 


Glu Ser Phe Arg Phe Gln Gln Glu Asn Leu Lys Arg Leu Arg Asp Ser 
                645                 650                 655     


Ile Thr Arg Arg Gln Arg Glu Lys Gln Lys Ser Gly Lys Gln Thr Asp 
            660                 665                 670         


Leu Glu Ile Thr Val Pro Ile Arg His Ser Gln His Leu Pro Ala Lys 
        675                 680                 685             


Val Glu Phe Gly Val Tyr Glu Ser Gly Pro Arg Lys Ser Val Ile Pro 
    690                 695                 700                 


Pro Arg Thr Glu Leu Arg Arg Gly Asp Trp Lys Thr Asp Ser Thr Ser 
705                 710                 715                 720 


Ser Thr Ala Ser Ser Thr Ser Asn Arg Ser Ser Thr Arg Ser Leu Leu 
                725                 730                 735     


Ser Val Ser Ser Gly Met Glu Gly Asp Asn Glu Asp Asn Glu Val Pro 
            740                 745                 750         


Glu Val Thr Arg Ser Arg Ser Pro Gly Pro Pro Gln Val Asp Gly Thr 
        755                 760                 765             


Pro Thr Met Ser Leu Glu Arg Pro Pro Arg Val Pro Pro Arg Ala Ala 
    770                 775                 780                 


Ser Gln Arg Pro Pro Thr Arg Glu Thr Phe His Pro Pro Pro Pro Val 
785                 790                 795                 800 


Pro Pro Arg Gly Arg 
                805 


<210>  24
<211>  1870
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (451)..(1701)
<223>  Pstpip1

<400>  24
acaaaccttc ctgcgcaggc ctcgggctgc ctgcctgcct gcctgcctgg cccggcccga       60

gctccagcct gcctcttcca ctggccactg cctcccaccc agggctggca tccctgctcc      120

ctgccctggg tcccagactg tgtcctccat caccgcaggg tcggtgaggg gctgggctgg      180

acaccagggc ccgccctccc atcactgagc tccactcctt cctcattttg ctgctgattc      240

tagccccaaa caaaacaggt tgagcttttt cctcccctca gaagctcctc tctggctcgt      300

ggctgccttc tgagtgttgc agacggcgcc ggccgggaag gggggcctgg gccagccctg      360

ccaggactgg gacgctgctg ctggcgcctg gccctccatc aggccagcct gtggcaggag      420

agtgagcttt gccgcggcag acgcctgagg atg atg ccc cag ctg cag ttc aaa       474
                                 Met Met Pro Gln Leu Gln Phe Lys          
                                 1               5                        

gat gcc ttt tgg tgc agg gac ttc aca gcc cac acg ggc tac gag gtg        522
Asp Ala Phe Trp Cys Arg Asp Phe Thr Ala His Thr Gly Tyr Glu Val           
    10                  15                  20                            

ctg ctg cag cgg ctt ctg gat ggc agg aag atg tgc aaa gac atg gag        570
Leu Leu Gln Arg Leu Leu Asp Gly Arg Lys Met Cys Lys Asp Met Glu           
25                  30                  35                  40            

gag cta ctg agg cag agg gcc cag gcg gag gag cgg tac ggg aag gag        618
Glu Leu Leu Arg Gln Arg Ala Gln Ala Glu Glu Arg Tyr Gly Lys Glu           
                45                  50                  55                

ctg gtg cag atc gca cgg aag gca ggt ggc cag acg gag atc aac tcc        666
Leu Val Gln Ile Ala Arg Lys Ala Gly Gly Gln Thr Glu Ile Asn Ser           
            60                  65                  70                    

ctg agg gcc tcc ttt gac tcc ttg aag cag caa atg gag aat gtg ggc        714
Leu Arg Ala Ser Phe Asp Ser Leu Lys Gln Gln Met Glu Asn Val Gly           
        75                  80                  85                        

agc tca cac atc cag ctg gcc ctg acc ctg cgt gag gag ctg cgg agt        762
Ser Ser His Ile Gln Leu Ala Leu Thr Leu Arg Glu Glu Leu Arg Ser           
    90                  95                  100                           

ctc gag gag ttt cgt gag agg cag aag gag cag agg aag aag tat gag        810
Leu Glu Glu Phe Arg Glu Arg Gln Lys Glu Gln Arg Lys Lys Tyr Glu           
105                 110                 115                 120           

gcc gtc atg gac cgg gtc cag aag agc aag ctg tcg ctc tac aag aag        858
Ala Val Met Asp Arg Val Gln Lys Ser Lys Leu Ser Leu Tyr Lys Lys           
                125                 130                 135               

gcc atg gag tcc aag aag aca tac gag cag aag tgc cgg gac gcg gac        906
Ala Met Glu Ser Lys Lys Thr Tyr Glu Gln Lys Cys Arg Asp Ala Asp           
            140                 145                 150                   

gac gcg gag cag gcc ttc gag cgc att agc gcc aac ggc cac cag aag        954
Asp Ala Glu Gln Ala Phe Glu Arg Ile Ser Ala Asn Gly His Gln Lys           
        155                 160                 165                       

cag gtg gag aag agt cag aac aaa gcc agg cag tgc aag gac tcg gcc       1002
Gln Val Glu Lys Ser Gln Asn Lys Ala Arg Gln Cys Lys Asp Ser Ala           
    170                 175                 180                           

acc gag gca gag cgg gta tac agg cag agc att gcg cag ctg gag aag       1050
Thr Glu Ala Glu Arg Val Tyr Arg Gln Ser Ile Ala Gln Leu Glu Lys           
185                 190                 195                 200           

gtc cgg gct gag tgg gag cag gag cac cgg acc acc tgt gag gcc ttt       1098
Val Arg Ala Glu Trp Glu Gln Glu His Arg Thr Thr Cys Glu Ala Phe           
                205                 210                 215               

cag ctg caa gag ttt gac cgg ctg acc att ctc cgc aac gcc ctg tgg       1146
Gln Leu Gln Glu Phe Asp Arg Leu Thr Ile Leu Arg Asn Ala Leu Trp           
            220                 225                 230                   

gtg cac agc aac cag ctc tcc atg cag tgt gtc aag gat gat gag ctc       1194
Val His Ser Asn Gln Leu Ser Met Gln Cys Val Lys Asp Asp Glu Leu           
        235                 240                 245                       

tac gag gaa gtg cgg ctg acg ctg gaa ggc tgc agc ata gac gcc gac       1242
Tyr Glu Glu Val Arg Leu Thr Leu Glu Gly Cys Ser Ile Asp Ala Asp           
    250                 255                 260                           

atc gac agt ttc atc cag gcc aag agc acg ggc aca gag ccc ccc gct       1290
Ile Asp Ser Phe Ile Gln Ala Lys Ser Thr Gly Thr Glu Pro Pro Ala           
265                 270                 275                 280           

ccg gtg ccc tac cag aac tat tac gat cgg gag gtc acc ccg ctg acc       1338
Pro Val Pro Tyr Gln Asn Tyr Tyr Asp Arg Glu Val Thr Pro Leu Thr           
                285                 290                 295               

agc agc cct ggc ata cag ccg tcc tgc ggc atg ata aag agg ttc tct       1386
Ser Ser Pro Gly Ile Gln Pro Ser Cys Gly Met Ile Lys Arg Phe Ser           
            300                 305                 310                   

gga ctg ctg cac gga agt ccc aag acc act tcg ttg gca gct tct gct       1434
Gly Leu Leu His Gly Ser Pro Lys Thr Thr Ser Leu Ala Ala Ser Ala           
        315                 320                 325                       

gcg tcc aca gag acc ctg acc ccc acc ccc gag cgg aat gag ggt gtc       1482
Ala Ser Thr Glu Thr Leu Thr Pro Thr Pro Glu Arg Asn Glu Gly Val           
    330                 335                 340                           

tac aca gcc atc gca gtg cag gag ata cag gga aac ccg gcc tca cca       1530
Tyr Thr Ala Ile Ala Val Gln Glu Ile Gln Gly Asn Pro Ala Ser Pro           
345                 350                 355                 360           

gcc cag gag tac cgg gcg ctc tac gat tat aca gcg cag aac cca gat       1578
Ala Gln Glu Tyr Arg Ala Leu Tyr Asp Tyr Thr Ala Gln Asn Pro Asp           
                365                 370                 375               

gag ctg gac ctg tcc gcg gga gac atc ctg gag gtg atc ctg gaa ggg       1626
Glu Leu Asp Leu Ser Ala Gly Asp Ile Leu Glu Val Ile Leu Glu Gly           
            380                 385                 390                   

gag gat ggc tgg tgg act gtg gag agg aac ggg cag cgt ggc ttc gtc       1674
Glu Asp Gly Trp Trp Thr Val Glu Arg Asn Gly Gln Arg Gly Phe Val           
        395                 400                 405                       

cct ggt tcc tac ctg gag aag ctt tga ggaagggcca ggagcccctt             1721
Pro Gly Ser Tyr Leu Glu Lys Leu                                           
    410                 415                                               

cggacctgcc ctgccagtgg agccagcagt gcccccagca ctgtccccac cttgctaggg     1781

cccagaacca agcgtccccc agccccgaga gggagcctgt cgtctcccag ggaataaagg     1841

agtgcgttct gttcaaaaaa aaaaaaaaa                                       1870


<210>  25
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Met Pro Gln Leu Gln Phe Lys Asp Ala Phe Trp Cys Arg Asp Phe 
1               5                   10                  15      


Thr Ala His Thr Gly Tyr Glu Val Leu Leu Gln Arg Leu Leu Asp Gly 
            20                  25                  30          


Arg Lys Met Cys Lys Asp Met Glu Glu Leu Leu Arg Gln Arg Ala Gln 
        35                  40                  45              


Ala Glu Glu Arg Tyr Gly Lys Glu Leu Val Gln Ile Ala Arg Lys Ala 
    50                  55                  60                  


Gly Gly Gln Thr Glu Ile Asn Ser Leu Arg Ala Ser Phe Asp Ser Leu 
65                  70                  75                  80  


Lys Gln Gln Met Glu Asn Val Gly Ser Ser His Ile Gln Leu Ala Leu 
                85                  90                  95      


Thr Leu Arg Glu Glu Leu Arg Ser Leu Glu Glu Phe Arg Glu Arg Gln 
            100                 105                 110         


Lys Glu Gln Arg Lys Lys Tyr Glu Ala Val Met Asp Arg Val Gln Lys 
        115                 120                 125             


Ser Lys Leu Ser Leu Tyr Lys Lys Ala Met Glu Ser Lys Lys Thr Tyr 
    130                 135                 140                 


Glu Gln Lys Cys Arg Asp Ala Asp Asp Ala Glu Gln Ala Phe Glu Arg 
145                 150                 155                 160 


Ile Ser Ala Asn Gly His Gln Lys Gln Val Glu Lys Ser Gln Asn Lys 
                165                 170                 175     


Ala Arg Gln Cys Lys Asp Ser Ala Thr Glu Ala Glu Arg Val Tyr Arg 
            180                 185                 190         


Gln Ser Ile Ala Gln Leu Glu Lys Val Arg Ala Glu Trp Glu Gln Glu 
        195                 200                 205             


His Arg Thr Thr Cys Glu Ala Phe Gln Leu Gln Glu Phe Asp Arg Leu 
    210                 215                 220                 


Thr Ile Leu Arg Asn Ala Leu Trp Val His Ser Asn Gln Leu Ser Met 
225                 230                 235                 240 


Gln Cys Val Lys Asp Asp Glu Leu Tyr Glu Glu Val Arg Leu Thr Leu 
                245                 250                 255     


Glu Gly Cys Ser Ile Asp Ala Asp Ile Asp Ser Phe Ile Gln Ala Lys 
            260                 265                 270         


Ser Thr Gly Thr Glu Pro Pro Ala Pro Val Pro Tyr Gln Asn Tyr Tyr 
        275                 280                 285             


Asp Arg Glu Val Thr Pro Leu Thr Ser Ser Pro Gly Ile Gln Pro Ser 
    290                 295                 300                 


Cys Gly Met Ile Lys Arg Phe Ser Gly Leu Leu His Gly Ser Pro Lys 
305                 310                 315                 320 


Thr Thr Ser Leu Ala Ala Ser Ala Ala Ser Thr Glu Thr Leu Thr Pro 
                325                 330                 335     


Thr Pro Glu Arg Asn Glu Gly Val Tyr Thr Ala Ile Ala Val Gln Glu 
            340                 345                 350         


Ile Gln Gly Asn Pro Ala Ser Pro Ala Gln Glu Tyr Arg Ala Leu Tyr 
        355                 360                 365             


Asp Tyr Thr Ala Gln Asn Pro Asp Glu Leu Asp Leu Ser Ala Gly Asp 
    370                 375                 380                 


Ile Leu Glu Val Ile Leu Glu Gly Glu Asp Gly Trp Trp Thr Val Glu 
385                 390                 395                 400 


Arg Asn Gly Gln Arg Gly Phe Val Pro Gly Ser Tyr Leu Glu Lys Leu 
                405                 410                 415     


<210>  26
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_44_P1004731

<400>  26
ctggcttaca gcttgtttgt tttataactt tacctctctc tgaaaagtct gtaagcaagg       60


<210>  27
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_42_P592157

<400>  27
aaagctttcg gttttgtttt ttaaactgtt tgcagagtgg agaagatcga tcaggaaggg       60


<210>  28
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_42_P495820

<400>  28
attatgcagg ctatgacgga actactacct tgctatggat gagggttggg caggatttaa       60


<210>  29
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe CUST_1_PI195698246

<400>  29
gtctcaagaa cagagggcta ccttggggag ccataaagag tgtatttaat aaaacgggct       60


<210>  30
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_44_P377266

<400>  30
aatgaaataa ctaagcatat cttttgagaa ttttattttc ttacatttta aatctgaagg       60


<210>  31
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_66_P100662

<400>  31
tttgtggtcc ctgttcagtc attatgttgt cccttcgctt ctcttgatca gcagaaagca       60


<210>  32
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_44_P928825

<400>  32
gaacgtgtgc acaaagtatc agcagaaatc cagtctgtga aagaagaaca agagcatgtg       60


<210>  33
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_42_P526140

<400>  33
ctcagtgtcc gtgaattggg tatccaagaa catcctgaag ccagaatgtc ttctcagaaa       60


<210>  34
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_42_P464736

<400>  34
aggctgagtt ctccagacca aaagaccatt tggaagttca aagatgtatt tgaggtttgc       60


<210>  35
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_43_P20022

<400>  35
agctctgagg ctcctgagct cagcacactg gactttggca aaatgactga ccgggaaacg       60


<210>  36
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_42_P515405

<400>  36
atttattcta acttatgcag gggtgcgaga tatgccccct tgctgtgaca cagatattta       60


<210>  37
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_43_P21121

<400>  37
acctggagac ccactgtcac tggtgatggt gtagccctgc tggtttgggt gatccttgaa       60


<210>  38
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_44_P180717

<400>  38
tggtgtgata aagaggttct ctgggctgct acatggaagt cccaagacca caccttctca       60


<210>  39
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_42_P602724

<400>  39
gtgactacgg gagtggggtg atgagaagct caaaaccgac ttcctttaat caattaacca       60


<210>  40
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_44_P332606

<400>  40
cctggtgagt tggggtcttt ttgacccttg tcacggttcc tccaacaaaa acttgcgcag       60


<210>  41
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_43_P12274

<400>  41
aggcagagga gaaggtgaag gcgtaaaaga agacgccagc actgactatg cctgcatcgt       60


<210>  42
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_44_P421534

<400>  42
tttctcagaa tgatgctggg caagagatct gccatcttga gaatgattct gatgtatgag       60


<210>  43
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_44_P248172

<400>  43
ggtttctcct ctatgttgat acagattacc tggattctat atcagaagac gatgagttgt       60


<210>  44
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_43_P13426

<400>  44
ttctcctttg attgctcttc ctaactggga ccaagttctg ggaaagaagg ctgatgttca       60


<210>  45
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_43_P11484

<400>  45
atcatattgc tgaaaatctt caaacacaaa ctctggggtg agcattacca ttgaacagtt       60


<210>  46
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_44_P285534

<400>  46
accccggaaa cgtattccta tttgaagcaa gttgaacgga cagagaaggg aagaagagaa       60


<210>  47
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Probe A_44_P421727

<400>  47
gagatgagta cctccggaaa cagaagacgg agaccatcat ctactcccga gaaaagaacc       60


<210>  48
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer RT1-A2 F

<400>  48
tccctccctg ctaccctgag                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer RT1-A2 R

<400>  49
gccatccaca cttgggtcaa                                                   20


<210>  50
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer RT1-DMb F

<400>  50
tcaaatctgc ctcgggtgtt t                                                 21


<210>  51
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer RT1-DMb R

<400>  51
gacaaggtgg ggctttcagg                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Psmb8 F

<400>  52
cactgctggg cagacatcct                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Psmb8 R

<400>  53
gctttgtctc cagcccaggt                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Ly6g6e F

<400>  54
cccaggcaaa gggacagaag                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Ly6g6e R

<400>  55
tgagaccctc aggcaccaag                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Aif1 F

<400>  56
tcccccagcc aagaaagcta                                                   20


<210>  57
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Aif1 R

<400>  57
tcttttccca tgctgctgtc a                                                 21


<210>  58
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Lst1 F

<400>  58
gggcaggagc tccactacg                                                    19


<210>  59
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Lst1 R

<400>  59
cgatgcaggc atagtcagtg c                                                 21


<210>  60
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer RT1-CE3 F

<400>  60
tgtcgtcctt ggagccatct                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer RT1-CE3 R

<400>  61
tcctcacaac aggcaccaga                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer RT1-CE10 F

<400>  62
acacaggtgg ggaaggagga                                                   20


<210>  63
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer RT1-CE10 R

<400>  63
caatctggga gggacacatc ag                                                22


<210>  64
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Primer RT-BM1(RT1-S3) F

<400>  64
gcagctatgc tcatgttcta ggc                                               23


<210>  65
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer RT-BM1(RT1-S3) R

<400>  65
tgccttctga ggccagtcag                                                   20


<210>  66
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Ubd F

<400>  66
tggggtgatg agaagctcaa aa                                                22


<210>  67
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Ubd R

<400>  67
ccccacctca aatctttatt tcattc                                            26


<210>  68
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Olr1 F

<400>  68
ggaagtcaga agagggcatg g                                                 21


<210>  69
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Olr1 R

<400>  69
tcctgggttc aatttccaga gt                                                22


<210>  70
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Ly49si1 F

<400>  70
tggccaatct gaattttcct tg                                                22


<210>  71
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Ly49si1 R

<400>  71
acatgggaag gggttcatgc                                                   20


<210>  72
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Ly49i9 F

<400>  72
gggacttggc aacctcagga                                                   20


<210>  73
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Ly49i9 R

<400>  73
ttggaacatc tgcacaatgg aa                                                22


<210>  74
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Cd3z F

<400>  74
agtgcctgct gggatttagc                                                   20


<210>  75
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Cd3z R

<400>  75
catccatggt cacaggcact t                                                 21


<210>  76
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer B2m F

<400>  76
gagcaggttg ctccacaggt                                                   20


<210>  77
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Primer B2m R

<400>  77
caagctttga gtgcaagaga ttga                                              24


