                         SEQUENCE LISTING

<110>  Fondazione Centro San Raffaele del Monte Tabor
       BROCCOLI, Vania
       CAIAZZO, Massimiliano
 
<120>  Method to generate dopaminergic neurons from mouse and human 
       cells

<130>  PCT 114925

<150>  US61/422,461
<151>  2010-12-13

<150>  US61/503,665
<151>  2011-07-01

<160>  110   

<170>  PatentIn version 3.5

<210>  1
<211>  696
<212>  DNA
<213>  Mus musculus

<400>  1
atggagagct ctggcaagat ggagagtgga gccggccagc agccgcagcc cccgcagccc       60

ttcctgcctc ccgcagcctg cttctttgcg accgcggcgg cggcggcagc ggcggcggcc      120

gcggcagctc agagcgcgca gcagcaacag ccgcaggcgc cgccgcagca ggcgccgcag      180

ctgagcccgg tggccgacag ccagccctca gggggcggtc acaagtcagc ggccaagcag      240

gtcaagcgcc agcgctcgtc ctctccggaa ctgatgcgct gcaaacgccg gctcaacttc      300

agcggcttcg gctacagcct gccacagcag cagccggccg ccgtggcgcg ccgcaacgag      360

cgcgagcgca accgggtcaa gttggtcaac ctgggttttg ccaccctccg ggagcatgtc      420

cccaacggcg cggccaacaa gaagatgagc aaggtggaga cgctgcgctc ggcggtcgag      480

tacatccgcg cgctgcagca gctgctggac gagcacgacg cggtgagcgc tgcctttcag      540

gcgggcgtcc tgtcgcccac catctccccc aactactcca acgacttgaa ctctatggcg      600

ggttctccgg tctcgtccta ctcctccgac gagggatcct acgaccctct tagcccagag      660

gaacaagagc tgctggactt taccaactgg ttctga                                696


<210>  2
<211>  231
<212>  PRT
<213>  Mus musculus

<400>  2

Met Glu Ser Ser Gly Lys Met Glu Ser Gly Ala Gly Gln Gln Pro Gln 
1               5                   10                  15      


Pro Pro Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe Ala Thr Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln Ser Ala Gln Gln 
        35                  40                  45              


Gln Gln Pro Gln Ala Pro Pro Gln Gln Ala Pro Gln Leu Ser Pro Val 
    50                  55                  60                  


Ala Asp Ser Gln Pro Ser Gly Gly Gly His Lys Ser Ala Ala Lys Gln 
65                  70                  75                  80  


Val Lys Arg Gln Arg Ser Ser Ser Pro Glu Leu Met Arg Cys Lys Arg 
                85                  90                  95      


Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu Pro Gln Gln Gln Pro 
            100                 105                 110         


Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg Asn Arg Val Lys Leu 
        115                 120                 125             


Val Asn Leu Gly Phe Ala Thr Leu Arg Glu His Val Pro Asn Gly Ala 
    130                 135                 140                 


Ala Asn Lys Lys Met Ser Lys Val Glu Thr Leu Arg Ser Ala Val Glu 
145                 150                 155                 160 


Tyr Ile Arg Ala Leu Gln Gln Leu Leu Asp Glu His Asp Ala Val Ser 
                165                 170                 175     


Ala Ala Phe Gln Ala Gly Val Leu Ser Pro Thr Ile Ser Pro Asn Tyr 
            180                 185                 190         


Ser Asn Asp Leu Asn Ser Met Ala Gly Ser Pro Val Ser Ser Tyr Ser 
        195                 200                 205             


Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ser Pro Glu Glu Gln Glu Leu 
    210                 215                 220                 


Leu Asp Phe Thr Asn Trp Phe 
225                 230     


<210>  3
<211>  2490
<212>  DNA
<213>  Homo sapiens

<400>  3
agcactctct cacttctggc cagggaacgt ggaaggcgca ccgacaggga tccggccagg       60

gagggcgagt gaaagaagga aatcagaaag gaagggagtt aacaaaataa taaaaacagc      120

ctgagccacg gctggagaga ccgagacccg gcgcaagaga gcgcagcctt agtaggagag      180

gaacgcgaga cgcggcagag cgcgttcagc actgactttt gctgctgctt ctgctttttt      240

ttttcttaga aacaagaagg cgccagcggc agcctcacac gcgagcgcca cgcgaggctc      300

ccgaagccaa cccgcgaagg gaggagggga gggaggagga ggcggcgtgc agggaggaga      360

aaaagcattt tcactttttt tgctcccact ctaagaagtc tcccggggat tttgtatata      420

ttttttaact tccgtcaggg ctcccgcttc atatttcctt ttctttccct ctctgttcct      480

gcacccaagt tctctctgtg tccccctcgc gggccccgca cctcgcgtcc cggatcgctc      540

tgattccgcg actccttggc cgccgctgcg catggaaagc tctgccaaga tggagagcgg      600

cggcgccggc cagcagcccc agccgcagcc ccagcagccc ttcctgccgc ccgcagcctg      660

tttctttgcc acggccgcag ccgcggcggc cgcagccgcc gcagcggcag cgcagagcgc      720

gcagcagcag cagcagcagc agcagcagca gcagcaggcg ccgcagctga gaccggcggc      780

cgacggccag ccctcagggg gcggtcacaa gtcagcgccc aagcaagtca agcgacagcg      840

ctcgtcttcg cccgaactga tgcgctgcaa acgccggctc aacttcagcg gctttggcta      900

cagcctgccg cagcagcagc cggccgccgt ggcgcgccgc aacgagcgcg agcgcaaccg      960

cgtcaagttg gtcaacctgg gctttgccac ccttcgggag cacgtcccca acggcgcggc     1020

caacaagaag atgagtaagg tggagacact gcgctcggcg gtcgagtaca tccgcgcgct     1080

gcagcagctg ctggacgagc atgacgcggt gagcgccgcc ttccaggcag gcgtcctgtc     1140

gcccaccatc tcccccaact actccaacga cttgaactcc atggccggct cgccggtctc     1200

atcctactcg tcggacgagg gctcttacga cccgctcagc cccgaggagc aggagcttct     1260

cgacttcacc aactggttct gaggggctcg gcctggtcag gccctggtgc gaatggactt     1320

tggaagcagg gtgatcgcac aacctgcatc tttagtgctt tcttgtcagt ggcgttggga     1380

gggggagaaa aggaaaagaa aaaaaaaaga agaagaagaa gaaaagagaa gaagaaaaaa     1440

acgaaaacag tcaaccaacc ccatcgccaa ctaagcgagg catgcctgag agacatggct     1500

ttcagaaaac gggaagcgct cagaacagta tctttgcact ccaatcattc acggagatat     1560

gaagagcaac tgggacctga gtcaatgcgc aaaatgcagc ttgtgtgcaa aagcagtggg     1620

ctcctggcag aagggagcag cacacgcgtt atagtaactc ccatcacctc taacacgcac     1680

agctgaaagt tcttgctcgg gtcccttcac ctcctcgccc tttcttaaag tgcagttctt     1740

agccctctag aaacgagttg gtgtctttcg tctcagtagc ccccacccca ataagctgta     1800

gacattggtt tacagtgaaa ctatgctatt ctcagccctt tgaaactctg cttctcctcc     1860

agggcccgat tcccaaaccc catggcttcc ctcacactgt cttttctacc attttcatta     1920

tagaatgctt ccaatctttt gtgaattttt tattataaaa aatctatttg tatctatcct     1980

aaccagttcg gggatatatt aagatatttt tgtacataag agagaaagag agagaaaaat     2040

ttatagaagt tttgtacaaa tggtttaaaa tgtgtatatc ttgatacttt aacatgtaat     2100

gctattacct ctgcatattt tagatgtgta gttcacctta caactgcaat tttccctatg     2160

tggttttgta aagaactctc ctcataggtg agatcaagag gccaccagtt gtacttcagc     2220

accaatgtgt cttactttat agaaatgttg ttaatgtatt aatgatgtta ttaaatactg     2280

ttcaagaaga acaaagttta tgcagctact gtccaaactc aaagtggcag ccagttggtt     2340

ttgataggtt gccttttgga gatttctatt actgcctttt tttttcttac tgttttatta     2400

caaacttaca aaaatatgta taaccctgtt ttatacaaac tagtttcgta ataaaacttt     2460

ttcctttttt taaaatgaaa ataaaaaaaa                                      2490


<210>  4
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Ser Ser Ala Lys Met Glu Ser Gly Gly Ala Gly Gln Gln Pro 
1               5                   10                  15      


Gln Pro Gln Pro Gln Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe 
            20                  25                  30          


Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln 
        35                  40                  45              


Ser Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Pro 
    50                  55                  60                  


Gln Leu Arg Pro Ala Ala Asp Gly Gln Pro Ser Gly Gly Gly His Lys 
65                  70                  75                  80  


Ser Ala Pro Lys Gln Val Lys Arg Gln Arg Ser Ser Ser Pro Glu Leu 
                85                  90                  95      


Met Arg Cys Lys Arg Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu 
            100                 105                 110         


Pro Gln Gln Gln Pro Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg 
        115                 120                 125             


Asn Arg Val Lys Leu Val Asn Leu Gly Phe Ala Thr Leu Arg Glu His 
    130                 135                 140                 


Val Pro Asn Gly Ala Ala Asn Lys Lys Met Ser Lys Val Glu Thr Leu 
145                 150                 155                 160 


Arg Ser Ala Val Glu Tyr Ile Arg Ala Leu Gln Gln Leu Leu Asp Glu 
                165                 170                 175     


His Asp Ala Val Ser Ala Ala Phe Gln Ala Gly Val Leu Ser Pro Thr 
            180                 185                 190         


Ile Ser Pro Asn Tyr Ser Asn Asp Leu Asn Ser Met Ala Gly Ser Pro 
        195                 200                 205             


Val Ser Ser Tyr Ser Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ser Pro 
    210                 215                 220                 


Glu Glu Gln Glu Leu Leu Asp Phe Thr Asn Trp Phe 
225                 230                 235     


<210>  5
<211>  1797
<212>  DNA
<213>  Mus musculus

<400>  5
atgccttgtg ttcaggcgca gtatgggtcc tcgcctcaag gagccagccc cgcttctcag       60

agctacagtt accactcttc gggagaatac agctccgatt tcttaactcc agagtttgtc      120

aagtttagca tggacctcac caacactgaa attactgcca ccacttctct ccccagcttc      180

agtaccttta tggacaacta cagcacaggc tacgacgtca agccaccttg cttgtaccaa      240

atgcccctgt ccggacagca gtcctccatt aaggtagaag acattcagat gcacaactac      300

cagcaacaca gccacctgcc ccctcagtcc gaggagatga tgccacacag cgggtcggtt      360

tactacaagc cctcttcgcc cccgacaccc agcaccccga gcttccaggt gcagcatagc      420

ccgatgtggg acgatccggg ctcccttcac aacttccacc agaactacgt ggccactacg      480

catatgatcg agcagaggaa gacacctgtc tcccgcctgt cactcttctc ctttaagcag      540

tcgcccccgg gcactcctgt gtctagctgc cagatgcgct tcgacgggcc tctgcacgtc      600

cccatgaacc cggagcccgc gggcagccac cacgtagtgg atgggcagac cttcgccgtg      660

cccaacccca ttcgcaagcc ggcatccatg ggcttcccgg gcctgcagat cggccacgca      720

tcgcagttgc ttgacacgca ggtgccctcg ccgccgtccc ggggctctcc ctccaatgag      780

ggtctgtgcg ctgtttgcgg tgacaacgcg gcctgtcagc actacggtgt tcgcacttgt      840

gagggctgca aaggtttctt taagcgcacg gtgcaaaaaa acgcgaaata tgtgtgttta      900

gcaaataaaa actgcccagt ggacaagcgc cgccgaaatc gttgtcagta ctgtcggttt      960

cagaagtgcc tagctgttgg gatggttaaa gaagtggttc gcacggacag tttaaaaggc     1020

cggagaggtc gtttaccctc gaagccgaag agcccacagg atccctctcc cccctcacct     1080

ccggtgagtc tgatcagtgc cctcgtcaga gcccacgtcg attccaatcc ggcaatgacc     1140

agcctggact attccaggtt ccaggcaaac cctgactatc agatgagtgg agatgatacc     1200

caacatatcc agcagttcta cgatctcctg accggctcta tggagatcat cagagggtgg     1260

gcagagaaga tccctggctt tgctgacctg cccaaagccg accaggacct gctttttgaa     1320

tcagctttct tagaattatt tgttctgcgc ttagcataca ggtccaaccc agtggagggt     1380

aaactcatct tttgcaatgg ggtggtcttg cacaggttgc aatgcgtgcg tggctttggg     1440

gaatggattg attccattgt tgaattctcc tccaacttgc agaatatgaa catcgacatt     1500

tctgccttct cctgcattgc tgccctggct atggtcacag agagacacgg gctcaaggaa     1560

cccaagagag tggaagagct acaaaacaaa attgtaaatt gtcttaaaga ccatgtgact     1620

ttcaataatg ggggtttgaa ccgacccaac tacctgtcta aactgttggg gaagctgcca     1680

gaactccgca ccctttgcac acagggcctc cagcgcattt tctacctgaa attggaagac     1740

ttggtaccac caccagcaat aattgacaaa cttttcctgg acaccttacc tttctaa        1797


<210>  6
<211>  598
<212>  PRT
<213>  Mus musculus

<400>  6

Met Pro Cys Val Gln Ala Gln Tyr Gly Ser Ser Pro Gln Gly Ala Ser 
1               5                   10                  15      


Pro Ala Ser Gln Ser Tyr Ser Tyr His Ser Ser Gly Glu Tyr Ser Ser 
            20                  25                  30          


Asp Phe Leu Thr Pro Glu Phe Val Lys Phe Ser Met Asp Leu Thr Asn 
        35                  40                  45              


Thr Glu Ile Thr Ala Thr Thr Ser Leu Pro Ser Phe Ser Thr Phe Met 
    50                  55                  60                  


Asp Asn Tyr Ser Thr Gly Tyr Asp Val Lys Pro Pro Cys Leu Tyr Gln 
65                  70                  75                  80  


Met Pro Leu Ser Gly Gln Gln Ser Ser Ile Lys Val Glu Asp Ile Gln 
                85                  90                  95      


Met His Asn Tyr Gln Gln His Ser His Leu Pro Pro Gln Ser Glu Glu 
            100                 105                 110         


Met Met Pro His Ser Gly Ser Val Tyr Tyr Lys Pro Ser Ser Pro Pro 
        115                 120                 125             


Thr Pro Ser Thr Pro Ser Phe Gln Val Gln His Ser Pro Met Trp Asp 
    130                 135                 140                 


Asp Pro Gly Ser Leu His Asn Phe His Gln Asn Tyr Val Ala Thr Thr 
145                 150                 155                 160 


His Met Ile Glu Gln Arg Lys Thr Pro Val Ser Arg Leu Ser Leu Phe 
                165                 170                 175     


Ser Phe Lys Gln Ser Pro Pro Gly Thr Pro Val Ser Ser Cys Gln Met 
            180                 185                 190         


Arg Phe Asp Gly Pro Leu His Val Pro Met Asn Pro Glu Pro Ala Gly 
        195                 200                 205             


Ser His His Val Val Asp Gly Gln Thr Phe Ala Val Pro Asn Pro Ile 
    210                 215                 220                 


Arg Lys Pro Ala Ser Met Gly Phe Pro Gly Leu Gln Ile Gly His Ala 
225                 230                 235                 240 


Ser Gln Leu Leu Asp Thr Gln Val Pro Ser Pro Pro Ser Arg Gly Ser 
                245                 250                 255     


Pro Ser Asn Glu Gly Leu Cys Ala Val Cys Gly Asp Asn Ala Ala Cys 
            260                 265                 270         


Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys 
        275                 280                 285             


Arg Thr Val Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys Asn 
    290                 295                 300                 


Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg Phe 
305                 310                 315                 320 


Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val Val Arg Thr Asp 
                325                 330                 335     


Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Ser Pro 
            340                 345                 350         


Gln Asp Pro Ser Pro Pro Ser Pro Pro Val Ser Leu Ile Ser Ala Leu 
        355                 360                 365             


Val Arg Ala His Val Asp Ser Asn Pro Ala Met Thr Ser Leu Asp Tyr 
    370                 375                 380                 


Ser Arg Phe Gln Ala Asn Pro Asp Tyr Gln Met Ser Gly Asp Asp Thr 
385                 390                 395                 400 


Gln His Ile Gln Gln Phe Tyr Asp Leu Leu Thr Gly Ser Met Glu Ile 
                405                 410                 415     


Ile Arg Gly Trp Ala Glu Lys Ile Pro Gly Phe Ala Asp Leu Pro Lys 
            420                 425                 430         


Ala Asp Gln Asp Leu Leu Phe Glu Ser Ala Phe Leu Glu Leu Phe Val 
        435                 440                 445             


Leu Arg Leu Ala Tyr Arg Ser Asn Pro Val Glu Gly Lys Leu Ile Phe 
    450                 455                 460                 


Cys Asn Gly Val Val Leu His Arg Leu Gln Cys Val Arg Gly Phe Gly 
465                 470                 475                 480 


Glu Trp Ile Asp Ser Ile Val Glu Phe Ser Ser Asn Leu Gln Asn Met 
                485                 490                 495     


Asn Ile Asp Ile Ser Ala Phe Ser Cys Ile Ala Ala Leu Ala Met Val 
            500                 505                 510         


Thr Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val Glu Glu Leu Gln 
        515                 520                 525             


Asn Lys Ile Val Asn Cys Leu Lys Asp His Val Thr Phe Asn Asn Gly 
    530                 535                 540                 


Gly Leu Asn Arg Pro Asn Tyr Leu Ser Lys Leu Leu Gly Lys Leu Pro 
545                 550                 555                 560 


Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu 
                565                 570                 575     


Lys Leu Glu Asp Leu Val Pro Pro Pro Ala Ile Ile Asp Lys Leu Phe 
            580                 585                 590         


Leu Asp Thr Leu Pro Phe 
        595             


<210>  7
<211>  3546
<212>  DNA
<213>  Homo sapiens

<400>  7
gctgacgcgc gctgacgcgc ggagacttta ggtgcatgtt ggcagcggca gcgcaagcca       60

cataaacaaa ggcacattgg cggccagggc cagtccgccc ggcggctcgc gcacggctcc      120

gcggtccctt ttgcctgtcc agccggccgc ctgtccctgc tccctccctc cgtgaggtgt      180

ccgggttccc ttcgcccagc tctcccaccc ctacccgacc ccggcgcccg ggctcccaga      240

gggaactgca cttcggcaga gttgaatgaa tgaagagaga cgcggagaac tcctaaggag      300

gagattggac aggctggact ccccattgct tttctaaaaa tcttggaaac tttgtccttc      360

attgaattac gacactgtcc acctttaatt tcctcgaaaa cgcctgtaac tcggctgaag      420

ccatgccttg tgttcaggcg cagtatgggt cctcgcctca aggagccagc cccgcttctc      480

agagctacag ttaccactct tcgggagaat acagctccga tttcttaact ccagagtttg      540

tcaagtttag catggacctc accaacactg aaatcactgc caccacttct ctccccagct      600

tcagtacctt tatggacaac tacagcacag gctacgacgt caagccacct tgcttgtacc      660

aaatgcccct gtccggacag cagtcctcca ttaaggtaga agacattcag atgcacaact      720

accagcaaca cagccacctg cccccccagt ctgaggagat gatgccgcac tccgggtcgg      780

tttactacaa gccctcctcg cccccgacgc ccaccacccc gggcttccag gtgcagcaca      840

gccccatgtg ggacgacccg ggatctctcc acaacttcca ccagaactac gtggccacta      900

cgcacatgat cgagcagagg aaaacgccag tctcccgcct ctccctcttc tcctttaagc      960

aatcgccccc tggcaccccg gtgtctagtt gccagatgcg cttcgacggg cccctgcacg     1020

tccccatgaa cccggagccc gccggcagcc accacgtggt ggacgggcag accttcgctg     1080

tgcccaaccc cattcgcaag cccgcgtcca tgggcttccc gggcctgcag atcggccacg     1140

cgtctcagct gctcgacacg caggtgccct caccgccgtc gcggggctcc ccctccaacg     1200

aggggctgtg cgctgtgtgt ggggacaacg cggcctgcca acactacggc gtgcgcacct     1260

gtgagggctg caaaggcttc tttaagcgca cagtgcaaaa aaatgcaaaa tacgtgtgtt     1320

tagcaaataa aaactgccca gtggacaagc gtcgccggaa tcgctgtcag tactgccgat     1380

ttcagaagtg cctggctgtt gggatggtca aagaagtggt tcgcacagac agtttaaaag     1440

gccggagagg tcgtttgccc tcgaaaccga agagcccaca ggagccctct cccccttcgc     1500

ccccggtgag tctgatcagt gccctcgtca gggcccatgt cgactccaac ccggctatga     1560

ccagcctgga ctattccagg ttccaggcga accctgacta tcaaatgagt ggagatgaca     1620

cccagcatat ccagcaattc tatgatctcc tgactggctc catggagatc atccggggct     1680

gggcagagaa gatccctggc ttcgcagacc tgcccaaagc cgaccaagac ctgctttttg     1740

aatcagcttt cttagaactg tttgtccttc gattagcata caggtccaac ccagtggagg     1800

gtaaactcat cttttgcaat ggggtggtct tgcacaggtt gcaatgcgtt cgtggctttg     1860

gggaatggat tgattccatt gttgaattct cctccaactt gcagaatatg aacatcgaca     1920

tttctgcctt ctcctgcatt gctgccctgg ctatggtcac agagagacac gggctcaagg     1980

aacccaagag agtggaagaa ctgcaaaaca agattgtaaa ttgtctcaaa gaccacgtga     2040

ctttcaacaa tggggggttg aaccgcccca attatttgtc caaactgttg gggaagctcc     2100

cagaacttcg taccctttgc acacaggggc tacagcgcat tttctacctg aaattggaag     2160

acttggtgcc accgccagca ataattgaca aacttttcct ggacacttta cctttctaag     2220

acctcctccc aagcacttca aaggaactgg aatgataatg gaaactgtca agagggggca     2280

agtcacatgg gcagagatag ccgtgtgagc agtctcagct caagctgccc cccatttctg     2340

taaccctcct agcccccttg atccctaaag aaaacaaaca aacaaacaaa aactgttgct     2400

atttcctaac ctgcaggcag aacctgaaag ggcattttgg ctccggggca tcctggattt     2460

agaacatgga ctacacacaa tacagtggta taaacttttt attctcagtt taaaaatcag     2520

tttgttgttc agaagaaaga ttgctataat gtataatggg aaatgtttgg ccatgcttgg     2580

ttgttgcagt tcagacaaat gtaacacaca cacacataca cacacacaca cacacacaga     2640

gacacatctt aaggggaccc acaagtattg ccctttaaca agacttcaaa gttttctgct     2700

gtaaagaaag ctgtaatata tagtaaaact aaatgttgcg tgggtggcat gagttgaaga     2760

aggcaaaggc ttgtaaattt acccaatgca gtttggcttt ttaaattatt ttgtgcctat     2820

ttatgaataa atattacaaa ttctaaaaga taagtgtgtt tgcaaaaaaa aagaaaataa     2880

atacataaaa aagggacaag catgttgatt ctaggttgaa aatgttatag gcacttgcta     2940

cttcagtaat gtctatatta tataaatagt atttcagaca ctatgtagtc tgttagattt     3000

tataaagatt ggtagttatc tgagcttaaa cattttctca attgtaaaat aggtgggcac     3060

aagtattaca catcagaaaa tcctgacaaa agggacacat agtgtttgta acaccgtcca     3120

acattccttg tttgtaagtg ttgtatgtac cgttgatgtt gataaaaaga aagtttatat     3180

cttgattatt ttgttgtcta aagctaaaca aaacttgcat gcagcagctt ttgactgttt     3240

ccagagtgct tataatatac ataactccct ggaaataact gagcactttg aatttttttt     3300

atgtctaaaa ttgtcagtta atttattatt ttgtttgagt aagaatttta atattgccat     3360

attctgtagt atttttcttt gtatatttct agtatggcac atgatatgag tcactgcctt     3420

tttttctatg gtgtatgaca gttagagatg ctgatttttt ttctgataaa ttctttcttt     3480

gagaaagaca attttaatgt ttacaacaat aaaccatgta aatgaacaga aaaaaaaaaa     3540

aaaaaa                                                                3546


<210>  8
<211>  598
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Pro Cys Val Gln Ala Gln Tyr Gly Ser Ser Pro Gln Gly Ala Ser 
1               5                   10                  15      


Pro Ala Ser Gln Ser Tyr Ser Tyr His Ser Ser Gly Glu Tyr Ser Ser 
            20                  25                  30          


Asp Phe Leu Thr Pro Glu Phe Val Lys Phe Ser Met Asp Leu Thr Asn 
        35                  40                  45              


Thr Glu Ile Thr Ala Thr Thr Ser Leu Pro Ser Phe Ser Thr Phe Met 
    50                  55                  60                  


Asp Asn Tyr Ser Thr Gly Tyr Asp Val Lys Pro Pro Cys Leu Tyr Gln 
65                  70                  75                  80  


Met Pro Leu Ser Gly Gln Gln Ser Ser Ile Lys Val Glu Asp Ile Gln 
                85                  90                  95      


Met His Asn Tyr Gln Gln His Ser His Leu Pro Pro Gln Ser Glu Glu 
            100                 105                 110         


Met Met Pro His Ser Gly Ser Val Tyr Tyr Lys Pro Ser Ser Pro Pro 
        115                 120                 125             


Thr Pro Thr Thr Pro Gly Phe Gln Val Gln His Ser Pro Met Trp Asp 
    130                 135                 140                 


Asp Pro Gly Ser Leu His Asn Phe His Gln Asn Tyr Val Ala Thr Thr 
145                 150                 155                 160 


His Met Ile Glu Gln Arg Lys Thr Pro Val Ser Arg Leu Ser Leu Phe 
                165                 170                 175     


Ser Phe Lys Gln Ser Pro Pro Gly Thr Pro Val Ser Ser Cys Gln Met 
            180                 185                 190         


Arg Phe Asp Gly Pro Leu His Val Pro Met Asn Pro Glu Pro Ala Gly 
        195                 200                 205             


Ser His His Val Val Asp Gly Gln Thr Phe Ala Val Pro Asn Pro Ile 
    210                 215                 220                 


Arg Lys Pro Ala Ser Met Gly Phe Pro Gly Leu Gln Ile Gly His Ala 
225                 230                 235                 240 


Ser Gln Leu Leu Asp Thr Gln Val Pro Ser Pro Pro Ser Arg Gly Ser 
                245                 250                 255     


Pro Ser Asn Glu Gly Leu Cys Ala Val Cys Gly Asp Asn Ala Ala Cys 
            260                 265                 270         


Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys 
        275                 280                 285             


Arg Thr Val Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys Asn 
    290                 295                 300                 


Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg Phe 
305                 310                 315                 320 


Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val Val Arg Thr Asp 
                325                 330                 335     


Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Ser Pro 
            340                 345                 350         


Gln Glu Pro Ser Pro Pro Ser Pro Pro Val Ser Leu Ile Ser Ala Leu 
        355                 360                 365             


Val Arg Ala His Val Asp Ser Asn Pro Ala Met Thr Ser Leu Asp Tyr 
    370                 375                 380                 


Ser Arg Phe Gln Ala Asn Pro Asp Tyr Gln Met Ser Gly Asp Asp Thr 
385                 390                 395                 400 


Gln His Ile Gln Gln Phe Tyr Asp Leu Leu Thr Gly Ser Met Glu Ile 
                405                 410                 415     


Ile Arg Gly Trp Ala Glu Lys Ile Pro Gly Phe Ala Asp Leu Pro Lys 
            420                 425                 430         


Ala Asp Gln Asp Leu Leu Phe Glu Ser Ala Phe Leu Glu Leu Phe Val 
        435                 440                 445             


Leu Arg Leu Ala Tyr Arg Ser Asn Pro Val Glu Gly Lys Leu Ile Phe 
    450                 455                 460                 


Cys Asn Gly Val Val Leu His Arg Leu Gln Cys Val Arg Gly Phe Gly 
465                 470                 475                 480 


Glu Trp Ile Asp Ser Ile Val Glu Phe Ser Ser Asn Leu Gln Asn Met 
                485                 490                 495     


Asn Ile Asp Ile Ser Ala Phe Ser Cys Ile Ala Ala Leu Ala Met Val 
            500                 505                 510         


Thr Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val Glu Glu Leu Gln 
        515                 520                 525             


Asn Lys Ile Val Asn Cys Leu Lys Asp His Val Thr Phe Asn Asn Gly 
    530                 535                 540                 


Gly Leu Asn Arg Pro Asn Tyr Leu Ser Lys Leu Leu Gly Lys Leu Pro 
545                 550                 555                 560 


Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu 
                565                 570                 575     


Lys Leu Glu Asp Leu Val Pro Pro Pro Ala Ile Ile Asp Lys Leu Phe 
            580                 585                 590         


Leu Asp Thr Leu Pro Phe 
        595             


<210>  9
<211>  1149
<212>  DNA
<213>  Mus musculus

<400>  9
atgttggacg gcctgaagat ggaggagaac tttcaaagtg cgattgagac ctcggcatct       60

ttctcctctt tgctgggcag agcggtgagc cccaagtctg tctgcgaggg ctgtcagcgg      120

gtcatctcgg acaggtttct gctgcggctc aacgacagct tctggcacga gcaatgcgtg      180

cagtgtgcct cctgcaaaga gcccctggag accacctgct tctaccggga caagaagctc      240

tactgcaagt accactacga gaaactgttt gctgtcaaat gtgggggctg cttcgaggcc      300

attgcgccca atgagtttgt catgcgtgcc cagaagagcg tataccacct gagctgcttc      360

tgctgctgcg tctgtgagcg acagctgcag aagggtgacg agtttgtcct gaaggagggc      420

cagctgctct gcaaagggga ctatgagaaa gaacgggagc tgctgagcct ggtgagccct      480

gcggcctcag actcaggcaa aagcgatgat gaggagagcc tttgcaagtc agcccatggg      540

gcaggaaaag gagcatcaga ggacggcaag gaccataagc gacccaaacg tcccagaacc      600

atcctgacca ctcagcagag gagagcattc aaggcctcgt ttgaagtatc ctccaagccc      660

tgcagaaagg tgagggagac tctggctgcg gagacagggc tgagtgtccg tgtggttcag      720

gtgtggttcc agaaccagcg agccaagatg aagaagctgg cccggcgaca gcagcaacag      780

caacaggacc aacagaacac ccagaggctg acttctgctc agacaaatgg tagtgggaat      840

gcgggcatgg aagggatcat gaacccctat acaacgttgc ccaccccaca gcagctgctg      900

gccattgaac agagcgtcta caactctgat cccttccgac agggtctcac cccaccccag      960

atgcctggag atcacatgca cccctatggt gctgaacctc ttttccatga cttggatagt     1020

gatgacacat ctctcagtaa cctgggagac tgcttcctgg caacctcaga agctgggccc     1080

ctgcagtcca gagtgggaaa ccccattgac catctgtact ccatgcagaa ttcctatttc     1140

acctcttga                                                             1149


<210>  10
<211>  381
<212>  PRT
<213>  Mus musculus

<400>  10

Met Leu Asp Gly Leu Lys Met Glu Glu Asn Phe Gln Ser Ala Ile Glu 
1               5                   10                  15      


Thr Ser Ala Ser Phe Ser Ser Leu Leu Gly Arg Ala Val Ser Pro Lys 
            20                  25                  30          


Ser Val Cys Glu Gly Cys Gln Arg Val Ile Ser Asp Arg Phe Leu Leu 
        35                  40                  45              


Arg Leu Asn Asp Ser Phe Trp His Glu Gln Cys Val Gln Cys Ala Ser 
    50                  55                  60                  


Cys Lys Glu Pro Leu Glu Thr Thr Cys Phe Tyr Arg Asp Lys Lys Leu 
65                  70                  75                  80  


Tyr Cys Lys Tyr His Tyr Glu Lys Leu Phe Ala Val Lys Cys Gly Gly 
                85                  90                  95      


Cys Phe Glu Ala Ile Ala Pro Asn Glu Phe Val Met Arg Ala Gln Lys 
            100                 105                 110         


Ser Val Tyr His Leu Ser Cys Phe Cys Cys Cys Val Cys Glu Arg Gln 
        115                 120                 125             


Leu Gln Lys Gly Asp Glu Phe Val Leu Lys Glu Gly Gln Leu Leu Cys 
    130                 135                 140                 


Lys Gly Asp Tyr Glu Lys Glu Arg Glu Leu Leu Ser Leu Val Ser Pro 
145                 150                 155                 160 


Ala Ala Ser Asp Ser Gly Lys Ser Asp Asp Glu Glu Ser Leu Cys Lys 
                165                 170                 175     


Ser Ala His Gly Ala Gly Lys Gly Ala Ser Glu Asp Gly Lys Asp His 
            180                 185                 190         


Lys Arg Pro Lys Arg Pro Arg Thr Ile Leu Thr Thr Gln Gln Arg Arg 
        195                 200                 205             


Ala Phe Lys Ala Ser Phe Glu Val Ser Ser Lys Pro Cys Arg Lys Val 
    210                 215                 220                 


Arg Glu Thr Leu Ala Ala Glu Thr Gly Leu Ser Val Arg Val Val Gln 
225                 230                 235                 240 


Val Trp Phe Gln Asn Gln Arg Ala Lys Met Lys Lys Leu Ala Arg Arg 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Asp Gln Gln Asn Thr Gln Arg Leu Thr Ser 
            260                 265                 270         


Ala Gln Thr Asn Gly Ser Gly Asn Ala Gly Met Glu Gly Ile Met Asn 
        275                 280                 285             


Pro Tyr Thr Thr Leu Pro Thr Pro Gln Gln Leu Leu Ala Ile Glu Gln 
    290                 295                 300                 


Ser Val Tyr Asn Ser Asp Pro Phe Arg Gln Gly Leu Thr Pro Pro Gln 
305                 310                 315                 320 


Met Pro Gly Asp His Met His Pro Tyr Gly Ala Glu Pro Leu Phe His 
                325                 330                 335     


Asp Leu Asp Ser Asp Asp Thr Ser Leu Ser Asn Leu Gly Asp Cys Phe 
            340                 345                 350         


Leu Ala Thr Ser Glu Ala Gly Pro Leu Gln Ser Arg Val Gly Asn Pro 
        355                 360                 365             


Ile Asp His Leu Tyr Ser Met Gln Asn Ser Tyr Phe Thr 
    370                 375                 380     


<210>  11
<211>  3555
<212>  DNA
<213>  Homo sapiens

<400>  11
agaagctgca ggatccgccc cggcgaagca gggccgactc gcacccagga ccctgggcct       60

ctgccttccc tcctagcctt ggagaagcaa ctggccctct cctcccgctg aggagcgacg      120

cgggctggta ggacgtcccg ggaaggccgg cagctcgcga ccacgtcccg gcccagcctg      180

ggcgcgccga ggagcagagc cagcggccgg cgttcgctcc ggctccctcc ccggcgctcc      240

gaagccgagg gcggctcctc cggctgcagt ctcgggggcg acgccttccc gggcagaagc      300

ttccagcagc gctccgcaac ttctctctgc tccagtcact gggagagagc tcgcctacca      360

ggtcctcccg gcccggcccg aacatgctgg acggcctaaa gatggaggag aacttccaaa      420

gcgcgatcga cacctcggcc tccttctcct cgctgctggg cagagcggtg agccccaagt      480

ctgtctgcga gggctgtcag cgggtcatct tggacaggtt tctgctgcgg ctcaacgaca      540

gcttctggca tgagcagtgc gtgcagtgcg cctcctgcaa agagcccctg gagaccacct      600

gcttctaccg ggacaagaag ctgtactgca agtatgacta cgagaagctg tttgctgtta      660

aatgtggggg ctgcttcgag gccatcgctc ccaatgagtt tgttatgcgg gcccagaaga      720

gtgtatacca cctgagctgc ttctgctgct gtgtctgcga gcgacagctt cagaagggtg      780

atgagtttgt cctgaaggag gggcagctgc tctgcaaagg ggactatgag aaggagcggg      840

agctgctcag cctggtgagc ccagcagcct cagactcagg taaaagtgat gatgaagaaa      900

gtctctgcaa gtcagcccat ggggcaggga aaggaactgc tgaggaaggc aaggaccata      960

agcgccccaa acgtccgaga accatcttga caactcaaca gaggcgagca ttcaaggcct     1020

catttgaagt atcctccaag ccctgcagga aggtgagaga gactctggct gcagagacag     1080

ggctgagtgt ccgtgtcgtc caggtgtggt tccaaaacca gagagcgaag atgaagaagc     1140

tggccaggcg acagcagcag cagcagcaag atcagcagaa cacccagagg ctgagctctg     1200

ctcagacaaa cggtggtggg agtgctggga tggaaggaat catgaacccc tacacggctc     1260

tgcccacccc acagcagctc ctggccatcg agcagagtgt ctacagctca gatcccttcc     1320

gacagggtct caccccaccc cagatgcctg gagaccacat gcacccttat ggtgccgagc     1380

cccttttcca tgacctggat agcgacgaca cctccctcag taacctgggt gattgtttcc     1440

tagcaacctc agaagctggg cctctgcagt ccagagtggg aaaccccatt gaccatctgt     1500

actccatgca gaattcttac ttcacatctt gagtcttccc ctagagttct gtgactaggc     1560

tcccatatgg aacaaccata ttctttgagg ggtcactggc tttaggacag ggaggccagg     1620

gaagaggtgg gttggggagg gagttttgtt ggggatgctg ttgtataatg atatggtgta     1680

gctcagcatt tccaaagact gaatacatta tggattgcat agtttaatgt ttctaataag     1740

agtcttagca ttagatatga agacgtgttt atcattaagg acagagactt ttaatataga     1800

cattctcatg caaactagat acttagggac tcctaacaac ttcccaccat gtcggggaag     1860

ctcttgtcaa gaggtgcata tgtctatcca tctacacacc aatagacaga aggacagata     1920

gatagatgtg tgtgtgtgag tgtgtaacct ttcgtatttt accctcaaag tttattccta     1980

attataacag acaccaactg tacagcaaaa gtaactttat tttcagtgtg aactatattt     2040

aaggaaatgc ttgatgcact taagttataa aatgagataa tttactttta taaactttat     2100

ttttagcttg acaagacttg tcagcagggc agagagggct gctccaccta gccccatagc     2160

tttgagtgct ggggttcatt ctgttttcag agtgtctttc agatctggaa agaaattctg     2220

tgtggctgat ggtgttctct cttgcattct tgctctcttt ggggttgaat cactgggcag     2280

gggtgggaca gaataatctc tgatcatgtt ctgagaaaat gtaaagccca gactcctggg     2340

ctttctttta aattctgaca agtggttgtt gggcagtgct aggatgattg gttcagctct     2400

tgagcttcag catctgcaaa tgtggatgag gctaatagta tgtacctacc tcactgggaa     2460

acaccaaggc ttaattcatt cccaggacac atgagcaggg ctgagactaa tatctgatat     2520

ttgtttaaga tacaaccagg ccactcactt ggcaaaggag ggtacatagg gttgcagagc     2580

aggagggctc ctgaactcca gagggcagtt ctgcctgctg aagtccctct gcaaagcctg     2640

tgctgaagga gacaccagct cagagcagtt cagagggatc ccagagtccc agagtgggga     2700

ggaggtgaag gctgagggga tagaggaggg cctggtggtg ttctagagca gggttgggca     2760

aactcctgct tgcgggcctg ctttctatgg cttgccagca aagaatggtt tttacttttt     2820

ttttgaggtc attaaaaaaa aggagaagaa gaatatataa caggctgtct gtggcctgga     2880

aagcctgaaa tatttgctat ctgtattgtc tggcccttac agaaaaagtt tggggcccct     2940

tgttttagag ggtctgtttc taaagaacct catggcgctc atagaggcag aaggttccag     3000

tggaaaccct tggctcttcc ttccaactca ctcctctgat cctcggcaca gaagacccag     3060

cagccattgt acatggggac agttccacac cctggtctcc agttgcggtg ctaggatggt     3120

attgttctgt gctaggaagt ctcctgggaa cccagaatga gttggtgggg aagacagcgg     3180

gtcactgtgg acccatccag gaggggccag gataggcttg gcctcatttc tggggacatc     3240

attggagact tgaacacaga gacacgtccc tatcactctg gcaaggccag agggaacatg     3300

tccccttatg gtagagtcta tgttgtgtga tttttgtgct cttgtttata atttatgcaa     3360

accaccaaga aacccaaacc agtctgatga gtgaaaatta tgcagatgct gtatggcccc     3420

acaggtttct gtggtaaaga ccagttggag aatgtaggag atactatgtg agtgaaaatg     3480

aatagagatc cttattccac tccttaatgg cataccaaga tgaaattaaa atctcttaca     3540

aatgaaaaaa aaaaa                                                      3555


<210>  12
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Leu Asp Gly Leu Lys Met Glu Glu Asn Phe Gln Ser Ala Ile Asp 
1               5                   10                  15      


Thr Ser Ala Ser Phe Ser Ser Leu Leu Gly Arg Ala Val Ser Pro Lys 
            20                  25                  30          


Ser Val Cys Glu Gly Cys Gln Arg Val Ile Leu Asp Arg Phe Leu Leu 
        35                  40                  45              


Arg Leu Asn Asp Ser Phe Trp His Glu Gln Cys Val Gln Cys Ala Ser 
    50                  55                  60                  


Cys Lys Glu Pro Leu Glu Thr Thr Cys Phe Tyr Arg Asp Lys Lys Leu 
65                  70                  75                  80  


Tyr Cys Lys Tyr Asp Tyr Glu Lys Leu Phe Ala Val Lys Cys Gly Gly 
                85                  90                  95      


Cys Phe Glu Ala Ile Ala Pro Asn Glu Phe Val Met Arg Ala Gln Lys 
            100                 105                 110         


Ser Val Tyr His Leu Ser Cys Phe Cys Cys Cys Val Cys Glu Arg Gln 
        115                 120                 125             


Leu Gln Lys Gly Asp Glu Phe Val Leu Lys Glu Gly Gln Leu Leu Cys 
    130                 135                 140                 


Lys Gly Asp Tyr Glu Lys Glu Arg Glu Leu Leu Ser Leu Val Ser Pro 
145                 150                 155                 160 


Ala Ala Ser Asp Ser Gly Lys Ser Asp Asp Glu Glu Ser Leu Cys Lys 
                165                 170                 175     


Ser Ala His Gly Ala Gly Lys Gly Thr Ala Glu Glu Gly Lys Asp His 
            180                 185                 190         


Lys Arg Pro Lys Arg Pro Arg Thr Ile Leu Thr Thr Gln Gln Arg Arg 
        195                 200                 205             


Ala Phe Lys Ala Ser Phe Glu Val Ser Ser Lys Pro Cys Arg Lys Val 
    210                 215                 220                 


Arg Glu Thr Leu Ala Ala Glu Thr Gly Leu Ser Val Arg Val Val Gln 
225                 230                 235                 240 


Val Trp Phe Gln Asn Gln Arg Ala Lys Met Lys Lys Leu Ala Arg Arg 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Asp Gln Gln Asn Thr Gln Arg Leu Ser Ser 
            260                 265                 270         


Ala Gln Thr Asn Gly Gly Gly Ser Ala Gly Met Glu Gly Ile Met Asn 
        275                 280                 285             


Pro Tyr Thr Ala Leu Pro Thr Pro Gln Gln Leu Leu Ala Ile Glu Gln 
    290                 295                 300                 


Ser Val Tyr Ser Ser Asp Pro Phe Arg Gln Gly Leu Thr Pro Pro Gln 
305                 310                 315                 320 


Met Pro Gly Asp His Met His Pro Tyr Gly Ala Glu Pro Leu Phe His 
                325                 330                 335     


Asp Leu Asp Ser Asp Asp Thr Ser Leu Ser Asn Leu Gly Asp Cys Phe 
            340                 345                 350         


Leu Ala Thr Ser Glu Ala Gly Pro Leu Gln Ser Arg Val Gly Asn Pro 
        355                 360                 365             


Ile Asp His Leu Tyr Ser Met Gln Asn Ser Tyr Phe Thr Ser 
    370                 375                 380         


<210>  13
<211>  1219
<212>  DNA
<213>  Mus musculus

<400>  13
atgttggacg gcatcaagat ggaggagcac gcccttcgcc ccgggcccgc caccctgggg       60

gtgctgctgg gctccgactg cccgcatccc gccgtctgcg agggctgcca gcggcccatc      120

tccgaccgct tcctgatgcg agtcaacgag tcgtcctggc acgaggagtg tttgcagtgc      180

gcggcatgtc agcaagccct caccaccagc tgctacttcc gggatcggaa actgtactgc      240

aaacaagact accaacagct cttcgcggca aagtgcagcg gctgcatgga gaagatcgcc      300

cctaccgagt tcgtcatgcg ggcgctggag tgtgtgtacc acttgggctg tttctgctgc      360

tgtgtgtgcg agaggcaact gcgcaagggg gacgagttcg tgctcaagga gggccagctg      420

ctgtgcaagg gtgactatga gaaggagaaa gacctgctca gctccgtgag cccggacgag      480

tctgactctg tgaagagtga ggatgaagat ggagacatga agccggccaa ggggcagggc      540

agccagagta aaggcagtgg agatgacggg aaagacccga gaaggcccaa acggccccga      600

accatcctca ccacacagca gcgaagagct ttcaaggcat cctttgaggt ctcctccaag      660

ccctgtcgga aggtccgaga gacattggca gcagagacag gcctcagcgt gcgtgtggtc      720

caggtctggt ttcagaacca aagagcaaag atgaagaagc tggcccggag acaccagcaa      780

cagcaggagc agcagaactc ccagcggctg ggccaagagg ttctgtcaag ccgcatggag      840

ggcatgatgg cctcctacac gccgctggcc cctccgcagc agcagatcgt ggccatggag      900

cagagcccct acggaagtag cgaccccttc caacagggcc tcacgccgcc ccaaatgcca      960

gggaacgact ccatcttcca cgatatcgat agtgatacct ccctcaccag cctcagcgac     1020

tgcttcctcg gctcttccga cgtgggctcc ctgcaggccc gcgtggggaa ccccattgac     1080

cggctctact ccatgcagag ctcctacttt gcctcctgag agccagccgg gccgcatgga     1140

cgcttgggcc tgggcctagg gtggagccac aggcctctgc agccagccgg ccccccagcc     1200

caccacccgc tcagactct                                                  1219


<210>  14
<211>  372
<212>  PRT
<213>  Mus musculus

<400>  14

Met Leu Asp Gly Ile Lys Met Glu Glu His Ala Leu Arg Pro Gly Pro 
1               5                   10                  15      


Ala Thr Leu Gly Val Leu Leu Gly Ser Asp Cys Pro His Pro Ala Val 
            20                  25                  30          


Cys Glu Gly Cys Gln Arg Pro Ile Ser Asp Arg Phe Leu Met Arg Val 
        35                  40                  45              


Asn Glu Ser Ser Trp His Glu Glu Cys Leu Gln Cys Ala Ala Cys Gln 
    50                  55                  60                  


Gln Ala Leu Thr Thr Ser Cys Tyr Phe Arg Asp Arg Lys Leu Tyr Cys 
65                  70                  75                  80  


Lys Gln Asp Tyr Gln Gln Leu Phe Ala Ala Lys Cys Ser Gly Cys Met 
                85                  90                  95      


Glu Lys Ile Ala Pro Thr Glu Phe Val Met Arg Ala Leu Glu Cys Val 
            100                 105                 110         


Tyr His Leu Gly Cys Phe Cys Cys Cys Val Cys Glu Arg Gln Leu Arg 
        115                 120                 125             


Lys Gly Asp Glu Phe Val Leu Lys Glu Gly Gln Leu Leu Cys Lys Gly 
    130                 135                 140                 


Asp Tyr Glu Lys Glu Lys Asp Leu Leu Ser Ser Val Ser Pro Asp Glu 
145                 150                 155                 160 


Ser Asp Ser Val Lys Ser Glu Asp Glu Asp Gly Asp Met Lys Pro Ala 
                165                 170                 175     


Lys Gly Gln Gly Ser Gln Ser Lys Gly Ser Gly Asp Asp Gly Lys Asp 
            180                 185                 190         


Pro Arg Arg Pro Lys Arg Pro Arg Thr Ile Leu Thr Thr Gln Gln Arg 
        195                 200                 205             


Arg Ala Phe Lys Ala Ser Phe Glu Val Ser Ser Lys Pro Cys Arg Lys 
    210                 215                 220                 


Val Arg Glu Thr Leu Ala Ala Glu Thr Gly Leu Ser Val Arg Val Val 
225                 230                 235                 240 


Gln Val Trp Phe Gln Asn Gln Arg Ala Lys Met Lys Lys Leu Ala Arg 
                245                 250                 255     


Arg His Gln Gln Gln Gln Glu Gln Gln Asn Ser Gln Arg Leu Gly Gln 
            260                 265                 270         


Glu Val Leu Ser Ser Arg Met Glu Gly Met Met Ala Ser Tyr Thr Pro 
        275                 280                 285             


Leu Ala Pro Pro Gln Gln Gln Ile Val Ala Met Glu Gln Ser Pro Tyr 
    290                 295                 300                 


Gly Ser Ser Asp Pro Phe Gln Gln Gly Leu Thr Pro Pro Gln Met Pro 
305                 310                 315                 320 


Gly Asn Asp Ser Ile Phe His Asp Ile Asp Ser Asp Thr Ser Leu Thr 
                325                 330                 335     


Ser Leu Ser Asp Cys Phe Leu Gly Ser Ser Asp Val Gly Ser Leu Gln 
            340                 345                 350         


Ala Arg Val Gly Asn Pro Ile Asp Arg Leu Tyr Ser Met Gln Ser Ser 
        355                 360                 365             


Tyr Phe Ala Ser 
    370         


<210>  15
<211>  5783
<212>  DNA
<213>  Homo sapiens

<400>  15
gcgtcccatg gatatagcaa caggtcccga gtcgctggag aggtgcttcc ctcgcgggca       60

gacggactgc gccaagatgt tggacggcat caagatggag gagcacgccc tgcgccccgg      120

gcccgccact ctgggggtgc tgctgggctc cgactgcccg catcccgccg tctgcgaggg      180

ctgccagcgg cccatctccg accgcttcct gatgcgagtc aacgagtcgt cctggcacga      240

ggagtgtttg cagtgcgcgg cgtgtcagca agccctcacc accagctgct acttccggga      300

tcggaaactg tactgcaaac aagactacca acagctcttc gcggccaagt gcagcggctg      360

catggagaag atcgccccca ccgagttcgt gatgcgggcg ctggagtgcg tgtaccacct      420

gggctgcttc tgctgctgcg tgtgtgaacg gcagctacgc aagggcgacg aattcgtgct      480

caaggagggc cagctgctgt gcaagggtga ctacgagaag gagaaggacc tgctcagctc      540

cgtgagcccc gacgagtccg actccgtgaa gagcgaggat gaagatgggg acatgaagcc      600

ggccaagggg cagggcagtc agagcaaggg cagcggggat gacgggaagg acccgcggag      660

gcccaagcga ccccggacca tcctcaccac gcagcagcga agagccttca aggcctcctt      720

cgaggtctcg tcgaagcctt gccgaaaggt ccgagagaca ctggcagctg agacgggcct      780

cagtgtgcgc gtggtccagg tctggtttca gaaccaaaga gcaaagatga agaagctggc      840

gcggcggcac cagcagcagc aggagcagca gaactcccag cggctgggcc aggaggtcct      900

gtccagccgc atggagggca tgatggcttc ctacacgccg ctggccccac cacagcagca      960

gatcgtggcc atggaacaga gcccctacgg cagcagcgac cccttccagc agggcctcac     1020

gccgccccaa atgccaggga acgactccat cttccatgac atcgacagcg atacctcctt     1080

aaccagcctc agcgactgct tcctcggctc ctcagacgtg ggctccctgc aggcccgcgt     1140

ggggaacccc atcgaccggc tctactccat gcagagttcc tacttcgcct cctgagagcc     1200

agccaggcgc acggacgctt gggcaggggc ctggggggga ctgccagcct ctgcggccag     1260

cctggccacc cccgccctgc tctccgcaca gactacagac agccatacgg tgccctcccc     1320

tcggccagct gggcctgacc actgtgcccg ttgggtacag ccagaccggt agatgggcac     1380

agcctgggca ggggctgtgt cctgcccaca gagaccttgt catccccagg gacccagagc     1440

tctcggacgg ccactcgcct cccagcccca cctcggcctc catcgcctcc tccccatctc     1500

ttttttggga agcttaaatt ctctctattt ttttaaatgt cctctctgtg tccatggccc     1560

tccatgcaag ccccaggaca atggtgtcat gaggcggtga cctgagaagc gtgtgtacct     1620

gtgccccagc aagggcaggg gtggcctctg ggggcaggcc cactgcctgg aaccgcacac     1680

ccctcagcct gagtctggag cagcagtgga gaggggcctg aggggaggca ctgtcaggag     1740

gcgggctcgg agcctgagcc tgggcaggcg caaagggaca gagaggcacg tgcagacaca     1800

tgcacacttg cagacaaacc cacgcaaaca cacacacagc tgtatgggga caccagaagg     1860

gacagggatg ctcagcgggt ctgtcctgcc ttgtcagaaa gagaaaagga ggccaggcag     1920

gggacccccc agttcttaag agcgattgga aagggaggaa ggggagagga agaggcgaac     1980

ttgaagcatc ggacccagtt gtatcccagc ctgggcccaa atgggggcag cctgggcagg     2040

gagggcagcc ccaggcccca ccaactctag aggcagatgg agcccccaga accaggtagc     2100

atcagaccag acaacagagc ctccaggggt cagggacttc agaagcacct gctgggcacc     2160

ccatctgcaa tgtggtcctc tccccagcca cctctgcctc ccctcacata cctccagtga     2220

caaggagctc actaggtcag cgagcccaca gcagctgtgc tgtcctgcat cccagagcca     2280

ggcttcccca gctctccctc ttaacactgt cccccagcag gcctccggct gtccctctaa     2340

aggtgtgggg caggtatcac ttcaccttcc cactgatgtc agccggccag aagtgagcag     2400

gcacatcacc tctcctgctg tggcaccctt cctctgttaa tttggcccaa aagacaatga     2460

tttggccaca tgaccttaga gattcaccct gccctgctgt agctaaatcc ctgggcccca     2520

cacgcaagtg acagctaagc cacatctgtt ttctgtgtat atgcaggatg ggggcaccta     2580

ctgttttgtt ttgttttgtt ttgttttgtt ttgttttgtt ttgttttgtt ttgtttgaga     2640

cggagtttcg ctcttgttgc ccaggctgga gtgcaatggc gcgatctcgg ctcaccacaa     2700

cctccgcctc ccaggttcaa gtgattctga tgcctcagcc tccctagtag ctgagattac     2760

aggcatgcgc caccacaccc agctaatttt gtatttttag tagcaacggg gtttctccat     2820

gttggtcagg ctggtctcca acccccgacc tcaggtgatc cgcctgcctc ggcctcccaa     2880

agtgctggga ttacaggcgt gagccaccgc acccagtctg cacttactgt ttagactgaa     2940

tgagggaccg tgacctcttt ccttttccat tccttcttac tcgattcatt ccagcctgtg     3000

gaatttctct gcaccctgat tcagtgacca ctgctctcct ctctcccagc acatctgccc     3060

agtgaggagt tggccctggg tctcacctga ggtgtgtgga ccgggctggc ctctccctgt     3120

ttgacattgg cccattaatg catcctcttt gggggacaca ttccaattgc atttcctgcc     3180

cccttctccc agggcaattg cagaagattg tgtcaggcgc cctgctggaa gtcaggtgca     3240

ctagatccat ccccagcccc agtctgctca actctatccc tgtcagagca aggaggctgg     3300

gctgctgggg cctgactggt gagcccaccc tgtcccctgg tgatcactgt gtccccttgt     3360

tcaggtgctc acaaccctac ctttaactct gaggtcaagc cctaggccac caccctaaag     3420

tctgcctggt ccaacctttg agcaagtaag gataatgaat gtcccttttc cacctttggg     3480

gccctctgcc tggatctctg gaatcctcta agttcaacct gttctgtggt tttgctcccg     3540

tttgctggga aattcagtcc ccccagaatg tcctgggcca acctccttgc ctgacatgtg     3600

gcctcgtgtc acccattggg ccccagcagc cagctagccc ttctgcagct cttcttacaa     3660

acagagcctc tccaaggacc tcagttgatg ttctggtcct tctgccgcct cagcccacca     3720

gggtccgtgc caccatgggt ctcttgagca gcagctgcac tggcttctgg agagacaccc     3780

ctctttctcc ttttgcacat gcaccatctg aatcgtgcca gggacatcct gggcagattc     3840

aggggcagat gccctatccc ccaggagacc tggcccttct ctctcagacc caataagttg     3900

gaagggacgt cagaagcggt catctcatct gccccttatt ttatagttgg aaaccctgag     3960

gcaagagagg gaaagaggcc tgtccaaggt ccgggttagt gacagagctg agctgagaac     4020

agggacgttg tgccccactg tcccctgtgg tttgtgaatg acctccaggt cagggggtca     4080

caacttgttc ttagtaaact tgccagctgt tggggtcaca tattcccatt ctggggcctc     4140

acaaaccccc gaatccagcc gggaccccat gccaggagct ggtctaggga cagcatgctt     4200

gtgacccaca gactgttaaa gccagaaggg acctcagaga gtcccttatg ctggaggcgc     4260

cctgtcagcc gtggctaggg gccccttgct ctatgctgtg ccttgctgcc cacaggctcc     4320

cagacaccag tgcccactct gcccagcccc ggactgggtg tggctcgcag atgaacaaga     4380

tgcagggcct gccttgaggg gtgtctccta gaaggaaagc cagactctcc ggcccagcca     4440

gagagtccag acatggcagg gacccgtttc tcagatgagg agcctgaggc tcagagaagg     4500

gaggcgatgt gttcagggcc acccagcaga agcctgtggg gctgggcaac cttctcccac     4560

tttatgggag gagctgcagc cttggctggg agctgggcgg ggagtagcca ggaccacccc     4620

ttgcccgtgc cgtgacatgg aaccttcatc actaaggggg ctggagtggg aagagggaga     4680

taactgtgtg gtctccagag caaaagagaa tgagaggtgg gcagggggag tcttggcaaa     4740

agaccaagtt ccacttccct gctggggaag tcaaggctca gaaagaggaa ataattgccc     4800

caggtaacac agggcagagg agggacaaaa agctgggcat ggccccagcc agagcctcat     4860

ctgcctactc cgtgaagcct cccaggtact ctgctatcct gggaaacgca cagggaggcc     4920

acacagagac actgctcaca agagtcagac caaggtgcca gcacagcctg gaaagagctc     4980

agaaaggggg ttggtgcacg tggctgggca tcttaggagg cttcctgagg gtgggtaaag     5040

gtgggaaggc cctggcgctg catcagatga gcagggcctg gcagggacaa gcctcttctc     5100

ctttgggaag ccctgcagcc tcctagcaag aggctgattc cccactctgc ccccatctga     5160

atgtcctttt catgttgcac gcagggaacc tcaggaagga ggattgcctg atgcctgcct     5220

ggctccatcc ttgagctctg ggcaccacct agggtgaggg agagcctgca gctctggggc     5280

taagtctgcc ctggggggaa agggctccac gctcacacgc acgcgctcgc acacacacac     5340

tcacacctgg acgcacacgg aggcttgcgg acccatactc acaggcacat gtggcctggg     5400

gactggggga gcaggaaaga cccctccaac atttggccct tggaaggcac cattgccaat     5460

gagcctcttt gctggttccc ccgaccccac ctgggggtcc catgggagcc cagcccagcc     5520

aggtgtgggg atgggccacc ggccattcct gttttccttg tacagacaga ttctcactac     5580

ccacccgcca tccccagaca cattttattt aataacttgt cattgttaaa ttatttatta     5640

gcgtttacca caccaccacc cccaccctgc cctccactct caccttccac ctcttcccac     5700

aacagcagaa aatggaaaca acaacaaaaa aagatgagac atcagtatat ttgtaaataa     5760

accgacctgt acactcaaaa aaa                                             5783


<210>  16
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Asp Ile Ala Thr Gly Pro Glu Ser Leu Glu Arg Cys Phe Pro Arg 
1               5                   10                  15      


Gly Gln Thr Asp Cys Ala Lys Met Leu Asp Gly Ile Lys Met Glu Glu 
            20                  25                  30          


His Ala Leu Arg Pro Gly Pro Ala Thr Leu Gly Val Leu Leu Gly Ser 
        35                  40                  45              


Asp Cys Pro His Pro Ala Val Cys Glu Gly Cys Gln Arg Pro Ile Ser 
    50                  55                  60                  


Asp Arg Phe Leu Met Arg Val Asn Glu Ser Ser Trp His Glu Glu Cys 
65                  70                  75                  80  


Leu Gln Cys Ala Ala Cys Gln Gln Ala Leu Thr Thr Ser Cys Tyr Phe 
                85                  90                  95      


Arg Asp Arg Lys Leu Tyr Cys Lys Gln Asp Tyr Gln Gln Leu Phe Ala 
            100                 105                 110         


Ala Lys Cys Ser Gly Cys Met Glu Lys Ile Ala Pro Thr Glu Phe Val 
        115                 120                 125             


Met Arg Ala Leu Glu Cys Val Tyr His Leu Gly Cys Phe Cys Cys Cys 
    130                 135                 140                 


Val Cys Glu Arg Gln Leu Arg Lys Gly Asp Glu Phe Val Leu Lys Glu 
145                 150                 155                 160 


Gly Gln Leu Leu Cys Lys Gly Asp Tyr Glu Lys Glu Lys Asp Leu Leu 
                165                 170                 175     


Ser Ser Val Ser Pro Asp Glu Ser Asp Ser Val Lys Ser Glu Asp Glu 
            180                 185                 190         


Asp Gly Asp Met Lys Pro Ala Lys Gly Gln Gly Ser Gln Ser Lys Gly 
        195                 200                 205             


Ser Gly Asp Asp Gly Lys Asp Pro Arg Arg Pro Lys Arg Pro Arg Thr 
    210                 215                 220                 


Ile Leu Thr Thr Gln Gln Arg Arg Ala Phe Lys Ala Ser Phe Glu Val 
225                 230                 235                 240 


Ser Ser Lys Pro Cys Arg Lys Val Arg Glu Thr Leu Ala Ala Glu Thr 
                245                 250                 255     


Gly Leu Ser Val Arg Val Val Gln Val Trp Phe Gln Asn Gln Arg Ala 
            260                 265                 270         


Lys Met Lys Lys Leu Ala Arg Arg His Gln Gln Gln Gln Glu Gln Gln 
        275                 280                 285             


Asn Ser Gln Arg Leu Gly Gln Glu Val Leu Ser Ser Arg Met Glu Gly 
    290                 295                 300                 


Met Met Ala Ser Tyr Thr Pro Leu Ala Pro Pro Gln Gln Gln Ile Val 
305                 310                 315                 320 


Ala Met Glu Gln Ser Pro Tyr Gly Ser Ser Asp Pro Phe Gln Gln Gly 
                325                 330                 335     


Leu Thr Pro Pro Gln Met Pro Gly Asn Asp Ser Ile Phe His Asp Ile 
            340                 345                 350         


Asp Ser Asp Thr Ser Leu Thr Ser Leu Ser Asp Cys Phe Leu Gly Ser 
        355                 360                 365             


Ser Asp Val Gly Ser Leu Gln Ala Arg Val Gly Asn Pro Ile Asp Arg 
    370                 375                 380                 


Leu Tyr Ser Met Gln Ser Ser Tyr Phe Ala Ser 
385                 390                 395 


<210>  17
<211>  1737
<212>  DNA
<213>  Mus musculus

<400>  17
caggtttatc tggtctcact ccatcccctc tagttttgga gctgctgggg ggtggggggg       60

acggcggggg tgggggacgc atctgcaact cctttaaaag cctgtgccca gcgtctcccg      120

ggttcttttt agttagtgct ggaacgtgga ggaagctgct ccctccgaag cagtaaacca      180

gcatttctgt ttgtttgttt gctttgccct tagttccgtc actccaaatc tacccaccaa      240

ggaccctgac cctgtccact ccaggcgaat cgagaccgtc cggctgggtc cccccaattt      300

gggccgactt tgcgcctcca aacaacctta gcatgatgtc ttatctaaag caaccgcctt      360

acgcagtcaa tgggctgagt ctgaccactt cgggtatgga cttgctgcat ccctccgtgg      420

gctaccccgc caccccccgg aaacagcgaa gggagaggac gacatttact agggcacagc      480

tcgacgttct ggaagctctg tttgccaaga cccggtaccc agacatcttc atgagggaag      540

aggtggcact gaaaatcaac ttgccagaat ccagggtgca ggtatggttt aagaatcgaa      600

gagctaagtg ccgccaacag cagcagcagc agcagaatgg aggtcagaac aaagtgaggc      660

ctgccaagaa gaagagctct ccagctcggg aagtgagttc agagagtgga acaagtggcc      720

agttcagtcc cccctctagt acctcagtcc caaccattgc cagcagcagt gctccagtgt      780

ctatctggag cccagcgtcc atctccccac tgtctgaccc cttgtccact tcctcctcct      840

gcatgcagag gtcctatccc atgacctata ctcaggcttc aggttatagt caaggctatg      900

ctggctcaac ttcctacttt gggggcatgg actgtggatc ttatttgacc cctatgcatc      960

accagcttcc tggaccaggg gccacactca gtcccatggg taccaatgct gttaccagcc     1020

atctcaatca gtccccagct tctctttcca cccagggata tggagcttca agcttgggtt     1080

ttaactcaac cactgattgc ttggattata aggaccaaac tgcctcttgg aagcttaact     1140

tcaatgctga ctgcttggat tataaagatc agacgtcctc atggaaattc caggttttgt     1200

gaagacctgt agaagctatt tttgtgggtg atttttaaat atgctgggct gaacattcca     1260

gttttagcca ggcattggtt aaaaaagtta gatggaacga tgctctcaga ctcctgatca     1320

aagttaccga gaggcataga aggaaaaagg aaggggcctt agaagggtcc atcaaccagc     1380

aacctgaaat ggacaaacca atctacttaa gattctgtta tagttctaga tcattggttt     1440

cctgatttgc aaatgattga tcaaatatat tctagcgaca tgcaaccaaa taccactcaa     1500

aacaaaaatc cagcaaaact gagttgtgag ggaagggagg gaaggtcatg gccttcaaag     1560

cagaggtgat ccggtgtttt agccaatctt tggttgaatc ttaggaatgg acaatgtccc     1620

aggctcattc acgtttcatg accaacaggt agttggcact gaaaaacttt tcagggctgt     1680

gtggattgtg cgactgattg tcctagatgc actactttat ttaaaaaaaa aaaaaaa        1737


<210>  18
<211>  289
<212>  PRT
<213>  Mus musculus

<400>  18

Met Met Ser Tyr Leu Lys Gln Pro Pro Tyr Ala Val Asn Gly Leu Ser 
1               5                   10                  15      


Leu Thr Thr Ser Gly Met Asp Leu Leu His Pro Ser Val Gly Tyr Pro 
            20                  25                  30          


Ala Thr Pro Arg Lys Gln Arg Arg Glu Arg Thr Thr Phe Thr Arg Ala 
        35                  40                  45              


Gln Leu Asp Val Leu Glu Ala Leu Phe Ala Lys Thr Arg Tyr Pro Asp 
    50                  55                  60                  


Ile Phe Met Arg Glu Glu Val Ala Leu Lys Ile Asn Leu Pro Glu Ser 
65                  70                  75                  80  


Arg Val Gln Val Trp Phe Lys Asn Arg Arg Ala Lys Cys Arg Gln Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Asn Gly Gly Gln Asn Lys Val Arg Pro Ala Lys 
            100                 105                 110         


Lys Lys Ser Ser Pro Ala Arg Glu Val Ser Ser Glu Ser Gly Thr Ser 
        115                 120                 125             


Gly Gln Phe Ser Pro Pro Ser Ser Thr Ser Val Pro Thr Ile Ala Ser 
    130                 135                 140                 


Ser Ser Ala Pro Val Ser Ile Trp Ser Pro Ala Ser Ile Ser Pro Leu 
145                 150                 155                 160 


Ser Asp Pro Leu Ser Thr Ser Ser Ser Cys Met Gln Arg Ser Tyr Pro 
                165                 170                 175     


Met Thr Tyr Thr Gln Ala Ser Gly Tyr Ser Gln Gly Tyr Ala Gly Ser 
            180                 185                 190         


Thr Ser Tyr Phe Gly Gly Met Asp Cys Gly Ser Tyr Leu Thr Pro Met 
        195                 200                 205             


His His Gln Leu Pro Gly Pro Gly Ala Thr Leu Ser Pro Met Gly Thr 
    210                 215                 220                 


Asn Ala Val Thr Ser His Leu Asn Gln Ser Pro Ala Ser Leu Ser Thr 
225                 230                 235                 240 


Gln Gly Tyr Gly Ala Ser Ser Leu Gly Phe Asn Ser Thr Thr Asp Cys 
                245                 250                 255     


Leu Asp Tyr Lys Asp Gln Thr Ala Ser Trp Lys Leu Asn Phe Asn Ala 
            260                 265                 270         


Asp Cys Leu Asp Tyr Lys Asp Gln Thr Ser Ser Trp Lys Phe Gln Val 
        275                 280                 285             


Leu 
    


<210>  19
<211>  2209
<212>  DNA
<213>  Homo sapiens

<400>  19
gagagcggga ccggcctcag ctccaacaca gcctccactg tgattaaaaa taaaaattgc       60

tagagcagcc ctcactcgcc acatctactt tgatagctgg ctatttggaa tttaaaggat      120

atttgacttt ttctaacctc ccatgaggct gtaagttcca ctgctccaaa cccacccacc      180

aaggactctg aacctgtcca ccccgggcgc atcaagatct tccagctggg tacccccgat      240

ttgggccgac tttgcacctc caaacaacct tagcatgatg tcttatctta agcaaccgcc      300

ttacgcagtc aatgggctga gtctgaccac ttcgggtatg gacttgctgc acccctccgt      360

gggctacccg gggccctggg cttcttgtcc cgcagccacc ccccggaaac agcgccggga      420

gaggacgacg ttcactcggg cgcagctaga tgtgctggaa gcactgtttg ccaagacccg      480

gtacccagac atcttcatgc gagaggaggt ggcactgaaa atcaacttgc ccgagtcgag      540

ggtgcaggta tggtttaaga atcgaagagc taagtgccgc caacaacagc aacaacagca      600

gaatggaggt caaaacaaag tgagacctgc caaaaagaag acatctccag ctcgggaagt      660

gagttcagag agtggaacaa gtggccaatt cactcccccc tctagcacct cagtcccgac      720

cattgccagc agcagtgctc ctgtgtctat ctggagccca gcttccatct ccccactgtc      780

agatcccttg tccacctcct cttcctgcat gcagaggtcc tatcccatga cctatactca      840

ggcttcaggt tatagtcaag gatatgctgg ctcaacttcc tactttgggg gcatggactg      900

tggatcatat ttgaccccta tgcatcacca gcttcccgga ccaggggcca cactcagtcc      960

catgggtacc aatgcagtca ccagccatct caatcagtcc ccagcttctc tttccaccca     1020

gggatatgga gcttcaagct tgggttttaa ctcaaccact gattgcttgg attataagga     1080

ccaaactgcc tcctggaagc ttaacttcaa tgctgactgc ttggattata aagatcagac     1140

atcctcgtgg aaattccagg ttttgtgaag acctgtagaa cctctttttg tgggtgattt     1200

ttaaatatac tgggctggac attccagttt tagccaggca ttggttaaaa gagttagatg     1260

ggatgatgct cagactcatc tgatcaaagt tccgagaggc atagaaggaa aaacgaaggg     1320

ccttagaggg gcctacaaac cagcaacatg aaatggacaa accaatctgc ttaagatcct     1380

gtcatagttt tagatcattg gttatcctga tttgcaaagt gatcaaaagc attctagcca     1440

tgtgcaacca aacaccacca aaaataaaat caaacaaaac taagttgtga aggaagggag     1500

ggaaggtcat agccttctta agcagaggtg ttccattgtt ttagccaatc cttggttgaa     1560

tcttaggaat gaacagtgtc tcaagctcat tcacgtttca tgaccaactg gtagttggca     1620

ctgaaaaaac ttttcagggc tgtgtgaatt gtgtgactga ttgtcctaga tgcactactt     1680

tatttaaaaa ataatgttca taaggagtca atatgtagtt taagagacaa tcagtgtgtg     1740

tcttataaat ggtacatctg tggtttttaa tctgtgctag acttcaaaac tgtgatctcc     1800

tgttattgta tgcaaccttg aactccacct ctgcaggggt tcttctgtga ttaaataggt     1860

tataattata agcaaaattc agagcaactg agtactgatc taaaaagatt acctttggct     1920

ggaggtgagc tgcactgaaa ctttacgaca aaatgtctct ggacaaagag agtcagagaa     1980

gagaagcaaa aggacactaa ttcatctgta atttactgtt ggtaagccta gcagtaaaga     2040

gacattggtc aattgctctg accctgatga attattaaac tgagatcatt gtcgtttatg     2100

cttgcagatg ttaaatggaa aagttatata tgcataaacc ttttcttcct ggatttggca     2160

gatatgtata attatattaa aatggttcta gcacaaaaaa aaaaaaaaa                 2209


<210>  20
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Met Ser Tyr Leu Lys Gln Pro Pro Tyr Ala Val Asn Gly Leu Ser 
1               5                   10                  15      


Leu Thr Thr Ser Gly Met Asp Leu Leu His Pro Ser Val Gly Tyr Pro 
            20                  25                  30          


Gly Pro Trp Ala Ser Cys Pro Ala Ala Thr Pro Arg Lys Gln Arg Arg 
        35                  40                  45              


Glu Arg Thr Thr Phe Thr Arg Ala Gln Leu Asp Val Leu Glu Ala Leu 
    50                  55                  60                  


Phe Ala Lys Thr Arg Tyr Pro Asp Ile Phe Met Arg Glu Glu Val Ala 
65                  70                  75                  80  


Leu Lys Ile Asn Leu Pro Glu Ser Arg Val Gln Val Trp Phe Lys Asn 
                85                  90                  95      


Arg Arg Ala Lys Cys Arg Gln Gln Gln Gln Gln Gln Gln Asn Gly Gly 
            100                 105                 110         


Gln Asn Lys Val Arg Pro Ala Lys Lys Lys Thr Ser Pro Ala Arg Glu 
        115                 120                 125             


Val Ser Ser Glu Ser Gly Thr Ser Gly Gln Phe Thr Pro Pro Ser Ser 
    130                 135                 140                 


Thr Ser Val Pro Thr Ile Ala Ser Ser Ser Ala Pro Val Ser Ile Trp 
145                 150                 155                 160 


Ser Pro Ala Ser Ile Ser Pro Leu Ser Asp Pro Leu Ser Thr Ser Ser 
                165                 170                 175     


Ser Cys Met Gln Arg Ser Tyr Pro Met Thr Tyr Thr Gln Ala Ser Gly 
            180                 185                 190         


Tyr Ser Gln Gly Tyr Ala Gly Ser Thr Ser Tyr Phe Gly Gly Met Asp 
        195                 200                 205             


Cys Gly Ser Tyr Leu Thr Pro Met His His Gln Leu Pro Gly Pro Gly 
    210                 215                 220                 


Ala Thr Leu Ser Pro Met Gly Thr Asn Ala Val Thr Ser His Leu Asn 
225                 230                 235                 240 


Gln Ser Pro Ala Ser Leu Ser Thr Gln Gly Tyr Gly Ala Ser Ser Leu 
                245                 250                 255     


Gly Phe Asn Ser Thr Thr Asp Cys Leu Asp Tyr Lys Asp Gln Thr Ala 
            260                 265                 270         


Ser Trp Lys Leu Asn Phe Asn Ala Asp Cys Leu Asp Tyr Lys Asp Gln 
        275                 280                 285             


Thr Ser Ser Trp Lys Phe Gln Val Leu 
    290                 295         


<210>  21
<211>  1379
<212>  DNA
<213>  Mus musculus

<400>  21
gcggccgccc cagagcaggg gggcggcccc caccccgcag ggtgcctggc ccctggcccc       60

tgcctgcgct ccagaacgcc gccgccacag ccaccacccg gagtctgcct gctgcgggac      120

gcactagacc tccctccatg gagtttgggc tgcttggtga ggcagaggcg cgaagccctg      180

cgctgtcgtt atcggacgca ggcactccac accctccgct tccagaacat ggctgcaagg      240

ggcaggagca cagtgactcg gagaaggcct cggcctcact gccggggggc tcccccgagg      300

acggctctct gaagaagaag cagcggcggc agcgcacgca cttcaccagc cagcagctgc      360

aggagctgga ggccaccttc cagaggaatc gctaccctga catgagcacc cgcgaagaga      420

tcgcggtgtg gaccaacctc actgaggccc gcgtgcgggt gtggttcaag aaccggcgcg      480

ccaagtggcg gaagcgggag cgcagccagc aggcggagct gtgcaaaggt ggcttcgcag      540

ccccgctcgg gggcctggtg ccaccctacg aggaggtgta cccgggctac tcgtacggca      600

actggccgcc caaggctctc gccccgccgc tcgccgccaa gaccttcccg ttcgccttca      660

actcggtcaa cgtggggcct ctggcttcac agcctgtatt ctcaccgccc agctccatcg      720

ccgcttctat ggtgccctcg gccgccgctg ccccgggcac cgtaccaggt cccggagcct      780

tgcagggcct gggcggggca ccccccgggc tggctccagc cgccgtgtcc tccggggcag      840

tgtcctgccc ttacgcctcg gccgccgcag ccgccgctgc agccgcctcc tccccctatg      900

tataccggga cccgtgtaac tcgagcctgg ctagcctgcg gctcaaagcc aagcagcacg      960

cctctttcag ctatcccgcc gtgcccgggc cgccgccggc cgctaacctt agcccctgcc     1020

agtacgccgt ggaacggccg gtgtgagccg caggtctgtg gatccatccc cgagggcggg     1080

gcagtaattc acagcctctc cggacagggg tcgcctagac tggcttgccc tcgtcccagg     1140

gtctgaaagg ggtgccagag cacccgggaa gaggccgcgg gcttcgaaga gggccttttc     1200

cctcgcagcc cccgagcggt ggtctgaccc ctatgcggag accgcgcccc taggactaag     1260

gccaggaaca gggaccagct cccccagggc caattcaccc ttggctcacc ccgccttctc     1320

cagactcccc ctatcccatt ttcaaagatc aatgaaataa acgtgcgcgg actgtcaaa      1379


<210>  22
<211>  302
<212>  PRT
<213>  Mus musculus

<400>  22

Met Glu Phe Gly Leu Leu Gly Glu Ala Glu Ala Arg Ser Pro Ala Leu 
1               5                   10                  15      


Ser Leu Ser Asp Ala Gly Thr Pro His Pro Pro Leu Pro Glu His Gly 
            20                  25                  30          


Cys Lys Gly Gln Glu His Ser Asp Ser Glu Lys Ala Ser Ala Ser Leu 
        35                  40                  45              


Pro Gly Gly Ser Pro Glu Asp Gly Ser Leu Lys Lys Lys Gln Arg Arg 
    50                  55                  60                  


Gln Arg Thr His Phe Thr Ser Gln Gln Leu Gln Glu Leu Glu Ala Thr 
65                  70                  75                  80  


Phe Gln Arg Asn Arg Tyr Pro Asp Met Ser Thr Arg Glu Glu Ile Ala 
                85                  90                  95      


Val Trp Thr Asn Leu Thr Glu Ala Arg Val Arg Val Trp Phe Lys Asn 
            100                 105                 110         


Arg Arg Ala Lys Trp Arg Lys Arg Glu Arg Ser Gln Gln Ala Glu Leu 
        115                 120                 125             


Cys Lys Gly Gly Phe Ala Ala Pro Leu Gly Gly Leu Val Pro Pro Tyr 
    130                 135                 140                 


Glu Glu Val Tyr Pro Gly Tyr Ser Tyr Gly Asn Trp Pro Pro Lys Ala 
145                 150                 155                 160 


Leu Ala Pro Pro Leu Ala Ala Lys Thr Phe Pro Phe Ala Phe Asn Ser 
                165                 170                 175     


Val Asn Val Gly Pro Leu Ala Ser Gln Pro Val Phe Ser Pro Pro Ser 
            180                 185                 190         


Ser Ile Ala Ala Ser Met Val Pro Ser Ala Ala Ala Ala Pro Gly Thr 
        195                 200                 205             


Val Pro Gly Pro Gly Ala Leu Gln Gly Leu Gly Gly Ala Pro Pro Gly 
    210                 215                 220                 


Leu Ala Pro Ala Ala Val Ser Ser Gly Ala Val Ser Cys Pro Tyr Ala 
225                 230                 235                 240 


Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser Pro Tyr Val Tyr 
                245                 250                 255     


Arg Asp Pro Cys Asn Ser Ser Leu Ala Ser Leu Arg Leu Lys Ala Lys 
            260                 265                 270         


Gln His Ala Ser Phe Ser Tyr Pro Ala Val Pro Gly Pro Pro Pro Ala 
        275                 280                 285             


Ala Asn Leu Ser Pro Cys Gln Tyr Ala Val Glu Arg Pro Val 
    290                 295                 300         


<210>  23
<211>  1407
<212>  DNA
<213>  Homo sapiens

<400>  23
ggagcgcccg agcggagagg cggcccggga gcaggggggc ggcccccact ccggccgggt       60

gcccggcccc tggcccctgc ctgccctcta gatcgccgcc gcagccgccg ctactgggag      120

tctgcctgtt gcaggacgca ctagccctcc ctccatggag ttcggcctgc tcagcgaggc      180

agaggcccgg agccctgccc tgtcgctgtc agacgctggc actccgcacc cccagctccc      240

agagcacggc tgcaagggcc aggagcacag cgactcagaa aaggcctcgg cttcgctgcc      300

cggcggctcc ccagaggacg gttcgctgaa aaagaagcag cggcggcagc gcacgcactt      360

caccagccag cagctacagg agctagaggc gaccttccag aggaaccgct accccgacat      420

gagcacgcgc gaggagatcg ccgtgtggac caacctcacc gaggcccgcg tgcgggtgtg      480

gttcaagaac cggcgcgcca aatggcggaa gcgcgagcgc agccagcagg ccgagctatg      540

caaaggcagc ttcgcggcgc cgctcggggg gctggtgccg ccctacgagg aggtgtaccc      600

cggctactcg tacggcaact ggccgcccaa ggctcttgcc ccgccgctcg ccgccaagac      660

ctttccattc gccttcaact cggtcaacgt ggggcctctg gcttcgcagc ccgtcttctc      720

gccacccagc tccatcgccg cctccatggt gccctccgcc gcggctgccc cgggcaccgt      780

gccagggcct ggggccctgc agggcctggg cgggggcccc cccgggctgg ctccggccgc      840

cgtgtcctcc ggggccgtgt cctgccctta tgcctcggcc gccgccgccg ccgcggctgc      900

cgcctcttcc ccctacgtct atcgggaccc gtgtaactcg agcctggcca gcctgcggct      960

caaagccaaa cagcacgcct ccttcagcta ccccgctgtg cacgggccgc ccccggcagc     1020

caaccttagt ccgtgccagt acgccgtgga aaggcccgta tgagcggccc cgcccgtaga     1080

tcatccccga gggcgggggc aacgattcac agcctccgcg gactggggtc attttgactg     1140

gcttgctccc gccccagggt ctgaaagggg tgtttgggca gctggggggc accggctcag     1200

gagagggcct tcccctccca gccctgaggg gtggactagg ccctacacac agaccgcgcc     1260

cctgggacta aagccaggaa cagggaccag ctccccgggg gccaactcac ccttggccca     1320

tcccgccttc tccaggcttc ccctccctcg ttttcaaaga taaatgaaat aaacgtgcgc     1380

ggactgtcaa aaaaaaaaaa aaaaaaa                                         1407


<210>  24
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Glu Phe Gly Leu Leu Ser Glu Ala Glu Ala Arg Ser Pro Ala Leu 
1               5                   10                  15      


Ser Leu Ser Asp Ala Gly Thr Pro His Pro Gln Leu Pro Glu His Gly 
            20                  25                  30          


Cys Lys Gly Gln Glu His Ser Asp Ser Glu Lys Ala Ser Ala Ser Leu 
        35                  40                  45              


Pro Gly Gly Ser Pro Glu Asp Gly Ser Leu Lys Lys Lys Gln Arg Arg 
    50                  55                  60                  


Gln Arg Thr His Phe Thr Ser Gln Gln Leu Gln Glu Leu Glu Ala Thr 
65                  70                  75                  80  


Phe Gln Arg Asn Arg Tyr Pro Asp Met Ser Thr Arg Glu Glu Ile Ala 
                85                  90                  95      


Val Trp Thr Asn Leu Thr Glu Ala Arg Val Arg Val Trp Phe Lys Asn 
            100                 105                 110         


Arg Arg Ala Lys Trp Arg Lys Arg Glu Arg Ser Gln Gln Ala Glu Leu 
        115                 120                 125             


Cys Lys Gly Ser Phe Ala Ala Pro Leu Gly Gly Leu Val Pro Pro Tyr 
    130                 135                 140                 


Glu Glu Val Tyr Pro Gly Tyr Ser Tyr Gly Asn Trp Pro Pro Lys Ala 
145                 150                 155                 160 


Leu Ala Pro Pro Leu Ala Ala Lys Thr Phe Pro Phe Ala Phe Asn Ser 
                165                 170                 175     


Val Asn Val Gly Pro Leu Ala Ser Gln Pro Val Phe Ser Pro Pro Ser 
            180                 185                 190         


Ser Ile Ala Ala Ser Met Val Pro Ser Ala Ala Ala Ala Pro Gly Thr 
        195                 200                 205             


Val Pro Gly Pro Gly Ala Leu Gln Gly Leu Gly Gly Gly Pro Pro Gly 
    210                 215                 220                 


Leu Ala Pro Ala Ala Val Ser Ser Gly Ala Val Ser Cys Pro Tyr Ala 
225                 230                 235                 240 


Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser Pro Tyr Val Tyr 
                245                 250                 255     


Arg Asp Pro Cys Asn Ser Ser Leu Ala Ser Leu Arg Leu Lys Ala Lys 
            260                 265                 270         


Gln His Ala Ser Phe Ser Tyr Pro Ala Val His Gly Pro Pro Pro Ala 
        275                 280                 285             


Ala Asn Leu Ser Pro Cys Gln Tyr Ala Val Glu Arg Pro Val 
    290                 295                 300         


<210>  25
<211>  2244
<212>  DNA
<213>  Mus musculus

<400>  25
gcagccactg aaccacaagc agctcggctt taactggagt gccttggagt cgcgtgccag       60

cagccacacg gccagggact gactgacaga caaccacgca cgagaacgac aacacacgag      120

actcgggcga gctgccgcgg tcgtccgggc tcttggcaaa gtcgcccagc cgagaggccc      180

ccccgcggag gtgcgcctag gaagcgccaa gcccgcggcg cggaggacac cgtgctcggt      240

tccgggctgc ggggacattc ccggacacac accggagcag cagctgcgcc gcgacacatc      300

tggagccgcg taggatgttc gtcaaatctg agactctgga gttgaaggag gaagaggagg      360

tactgatgct gctgggctcg gcttccccgg cctcggcgac cctgaccccg atgtcctcca      420

gcgcggacga ggaggaggac gaggagctgc gccggccggg ctccgcgcgt gggcagcgtg      480

gagcggaagc cgggcagggg gtgcagggca gtccggcgtc gggtgccggg ggttgccggc      540

cagggcggct gctgggcctg atgcacgagt gcaagcgtcg cccgtcgcgc tcacgggccg      600

tctcccgagg tgccaagacg gcggagacgg tgcagcgcat caagaagacc cgcaggctca      660

aggccaacaa ccgcgagcgc aaccgcatgc acaacctaaa cgccgcgctg gacgcgctgc      720

gcgaggtgct gcccaccttc cccgaggatg ccaagctcac gaagatcgag acgctgcgct      780

tcgcccacaa ttacatctgg gcgctcaccg agactctgcg cctggcggac cactgcgccg      840

gcgccggtgg cctccagggg gcgctcttca cggaggcggt gctcctgagc ccgggagctg      900

cgctcggcgc cagcggggac agcccttctc caccttcctc ctggagctgc accaacagcc      960

cggcgtcatc ctccaactcc acgtccccat acagctgcac tttatcgccc gctagccccg     1020

ggtcagacgt ggactactgg cagcccccac ctccggagaa gcatcgttat gcgcctcacc     1080

tgcccctcgc cagggactgt atctagagct gcgggtctcc ctctctcgtc ctctacccgg     1140

ccctcttccc atccttctcc cgcccctcac cctccacgcc ccggactcca cttcacagag     1200

cagaggtggc ccttgcaatc ccctcggcgg ctggtgcatt cgggggtgga gaccagctct     1260

ggtttattga agatgtgagg atttatggtc aaagaggact atggcgtgtg ggagtggggg     1320

ctggcgtggg gaacctcgta agactgtaaa agacactgag aaaaagtacc ataactaacg     1380

agtgtgcaga gcagactgac gctcctcccc tctctcagag ctgctggagg agaactccgg     1440

gcaggcagtt cgtgtgaatc tctcagaggg aatgcaactg gtccctgtga tcttttcacc     1500

ttcgtttcta catagagatg ttaatgtcag tcgaaagaaa tgtattttag catctgaatg     1560

aatttactgg taataatatt atccacacat ttgcaatggc tggcatctgc tctattccca     1620

ttgctgtctg caggctgtgg gaatttcacc tgtcaaacca aactttccct ctctgatgtg     1680

cactttgttt ttttcccaga ttcgtcacaa tgcctattgt cccgcccttc tttttgcttt     1740

ttttctccat tttgccatct gtctcttatg atttataagg gggaaaaact tgttttgtta     1800

gagggccagg ttagaagtca ttgtataatt tgtaggcttt tgtaagggtt gaatgcaagc     1860

gtggaaattt aggctgaatt ctctatcaaa agaaaaaatg tgaaggaaaa aggaaaaatc     1920

aggagggagg attgcttcat gcattattta tctcgacctt ttaggggaga aggaactccc     1980

ccatcctttc aagagattaa aaataaatca acagtctgaa aacctaagca gacacggggc     2040

attgccagga tcagccacac acgtgtttcc ttctatttat tttgaagaaa aatttcatgg     2100

gaaagtatgt atttttttgt atattctaca gagtttattc tagtatgtat ttacatcccg     2160

aagaataaga aaattgtttt gtgattaagc tataaataaa gtatctaatt ttcataaaaa     2220

aaaaaaaaaa aaaaaaaaaa aaaa                                            2244


<210>  26
<211>  263
<212>  PRT
<213>  Mus musculus

<400>  26

Met Phe Val Lys Ser Glu Thr Leu Glu Leu Lys Glu Glu Glu Glu Val 
1               5                   10                  15      


Leu Met Leu Leu Gly Ser Ala Ser Pro Ala Ser Ala Thr Leu Thr Pro 
            20                  25                  30          


Met Ser Ser Ser Ala Asp Glu Glu Glu Asp Glu Glu Leu Arg Arg Pro 
        35                  40                  45              


Gly Ser Ala Arg Gly Gln Arg Gly Ala Glu Ala Gly Gln Gly Val Gln 
    50                  55                  60                  


Gly Ser Pro Ala Ser Gly Ala Gly Gly Cys Arg Pro Gly Arg Leu Leu 
65                  70                  75                  80  


Gly Leu Met His Glu Cys Lys Arg Arg Pro Ser Arg Ser Arg Ala Val 
                85                  90                  95      


Ser Arg Gly Ala Lys Thr Ala Glu Thr Val Gln Arg Ile Lys Lys Thr 
            100                 105                 110         


Arg Arg Leu Lys Ala Asn Asn Arg Glu Arg Asn Arg Met His Asn Leu 
        115                 120                 125             


Asn Ala Ala Leu Asp Ala Leu Arg Glu Val Leu Pro Thr Phe Pro Glu 
    130                 135                 140                 


Asp Ala Lys Leu Thr Lys Ile Glu Thr Leu Arg Phe Ala His Asn Tyr 
145                 150                 155                 160 


Ile Trp Ala Leu Thr Glu Thr Leu Arg Leu Ala Asp His Cys Ala Gly 
                165                 170                 175     


Ala Gly Gly Leu Gln Gly Ala Leu Phe Thr Glu Ala Val Leu Leu Ser 
            180                 185                 190         


Pro Gly Ala Ala Leu Gly Ala Ser Gly Asp Ser Pro Ser Pro Pro Ser 
        195                 200                 205             


Ser Trp Ser Cys Thr Asn Ser Pro Ala Ser Ser Ser Asn Ser Thr Ser 
    210                 215                 220                 


Pro Tyr Ser Cys Thr Leu Ser Pro Ala Ser Pro Gly Ser Asp Val Asp 
225                 230                 235                 240 


Tyr Trp Gln Pro Pro Pro Pro Glu Lys His Arg Tyr Ala Pro His Leu 
                245                 250                 255     


Pro Leu Ala Arg Asp Cys Ile 
            260             


<210>  27
<211>  2370
<212>  DNA
<213>  Homo sapiens

<400>  27
cgcagccact gaaccacaag cagcttcgcg ttaactggag tgcctgggag tcgcgtgcca       60

ggagccgcac ggccagggac tgactgacag acagacacgc accaccacca caacacacga      120

gacccgggcg ggccgccgcc gccgccgccg gggctcttgg caaactcgcc ggtcgcagag      180

gtcccccgcg gagctgcgcc acagtagcgc cgggcttgca gctttcacgc cgggcgaagg      240

acccggcgct gcgctcgcag ctgcgcggag attcccggca caggccaaag tcacagcaac      300

gctgaggcac agttagagcc aactaagatg ttcgtcaaat ccgagacctt ggagttgaag      360

gaggaagagg acgtgttagt gctgctcgga tcggcctccc ccgccttggc ggccctgacc      420

ccgctgtcat ccagcgccga cgaagaagag gaggaggagc cgggcgcgtc aggcggggcg      480

cgtcggcagc gcggggctga ggccgggcag ggggcgcggg gcggcgtggc tgcgggtgcg      540

gagggctgcc ggcccgcacg gctgctgggt ctggtacacg attgcaaacg gcgcccttcc      600

cgggcgcggg ccgtctcccg aggcgccaag acggccgaga cggtgcagcg catcaagaag      660

acccgtagac tgaaggccaa caaccgcgag cgaaaccgca tgcacaacct caacgcggca      720

ctggacgcgc tgcgcgaggt gctccccacg ttccccgagg acgccaagct caccaagatc      780

gagaccctgc gcttcgccca caactacatc tgggcactca ccgagaccct gcgcctggcg      840

gatcactgcg ggggcggcgg cgggggcctg ccgggggcgc tcttctccga ggcagtgttg      900

ctgagcccgg gaggcgccag cgccgccctg agcagcagcg gagacagccc ctcgcccgcc      960

tccacgtgga gttgcaccaa cagccccgcg ccgtcctcct ccgtgtcctc caattccacc     1020

tccccctaca gctgcacttt atcgcccgcc agcccggccg ggtcagacat ggactattgg     1080

cagcccccac ctcccgacaa gcaccgctat gcacctcacc tccccatagc cagggattgt     1140

atctagagct gccatttctg ctacccacgc caggccttag tgggttccct ttcctgtccc     1200

cagtcgagcc ctcctccctt cccctgcccc tcctttccac gccctggaaa ccatctcact     1260

tcacagggca ggtgtagcct ttctgattcc tcggttgttt cttgcatttc ttggctttgg     1320

gtatccttca ttcagacggg ctctgattta ctgaaggtgt gatggagctt attgtcaaag     1380

ccaagggtgg cgttttgggg gcgcttcttg agacgaaaaa gaccctggga agagatgatg     1440

gtggcatatc taaagagttt gcagagcgga ctgacgctcc tcccctttct ctttaacgcc     1500

gaaggacttg gtgcagttcg tgtgaatctc acagggggaa tgcaactggt tcctgtgatc     1560

tcttcacctt tgcttctaca tagagatgtt aatgtcgagt agaaagaaat gtatcttagc     1620

atctgaatga ttttgctggt aataatatta tccacagatt tgcaatggct ggcatctgct     1680

ttattcccat tgctgtctgc aggctgtggg aatttcacct gtcaaaccaa acttccctct     1740

ctgatgtgca ctttgttctg tttcccagat tcgtcacaat gcctattgtc ctgtccttct     1800

ctttcctttt tcttccccat tttgccatct gtctcttatg atttataagg ggaaaaaaac     1860

ttgttttgtt agaggggcag gttagaagtc attgtataat ttgtaggctt tgtaatgatt     1920

gaatgcaagc gtggaaattt aggctgaact ctctatcaaa aggaaaaatg tggaggaaaa     1980

gggaaaaatc aggagggagg attgcctcat gtattattta tttcgacctt ttaggggaga     2040

aggaactccc ccattctttc aagagattaa aaataaatca acagtctgaa aacctaagca     2100

gacacggagc attatccgga tcagccacac acgtgttccc ttctatttat tataaagaaa     2160

tttttcatgg gaaaatatgt attttttgta tattctacag agtttattct agtatgtatt     2220

tacatcttga agaacaagaa agttgttctt gtgattaaac tataaataaa ctatctaatt     2280

ttcataaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2340

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                      2370


<210>  28
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Phe Val Lys Ser Glu Thr Leu Glu Leu Lys Glu Glu Glu Asp Val 
1               5                   10                  15      


Leu Val Leu Leu Gly Ser Ala Ser Pro Ala Leu Ala Ala Leu Thr Pro 
            20                  25                  30          


Leu Ser Ser Ser Ala Asp Glu Glu Glu Glu Glu Glu Pro Gly Ala Ser 
        35                  40                  45              


Gly Gly Ala Arg Arg Gln Arg Gly Ala Glu Ala Gly Gln Gly Ala Arg 
    50                  55                  60                  


Gly Gly Val Ala Ala Gly Ala Glu Gly Cys Arg Pro Ala Arg Leu Leu 
65                  70                  75                  80  


Gly Leu Val His Asp Cys Lys Arg Arg Pro Ser Arg Ala Arg Ala Val 
                85                  90                  95      


Ser Arg Gly Ala Lys Thr Ala Glu Thr Val Gln Arg Ile Lys Lys Thr 
            100                 105                 110         


Arg Arg Leu Lys Ala Asn Asn Arg Glu Arg Asn Arg Met His Asn Leu 
        115                 120                 125             


Asn Ala Ala Leu Asp Ala Leu Arg Glu Val Leu Pro Thr Phe Pro Glu 
    130                 135                 140                 


Asp Ala Lys Leu Thr Lys Ile Glu Thr Leu Arg Phe Ala His Asn Tyr 
145                 150                 155                 160 


Ile Trp Ala Leu Thr Glu Thr Leu Arg Leu Ala Asp His Cys Gly Gly 
                165                 170                 175     


Gly Gly Gly Gly Leu Pro Gly Ala Leu Phe Ser Glu Ala Val Leu Leu 
            180                 185                 190         


Ser Pro Gly Gly Ala Ser Ala Ala Leu Ser Ser Ser Gly Asp Ser Pro 
        195                 200                 205             


Ser Pro Ala Ser Thr Trp Ser Cys Thr Asn Ser Pro Ala Pro Ser Ser 
    210                 215                 220                 


Ser Val Ser Ser Asn Ser Thr Ser Pro Tyr Ser Cys Thr Leu Ser Pro 
225                 230                 235                 240 


Ala Ser Pro Ala Gly Ser Asp Met Asp Tyr Trp Gln Pro Pro Pro Pro 
                245                 250                 255     


Asp Lys His Arg Tyr Ala Pro His Leu Pro Ile Ala Arg Asp Cys Ile 
            260                 265                 270         


<210>  29
<211>  2554
<212>  DNA
<213>  Mus musculus

<400>  29
cgattaaagg cgctgccagc ctcgctctct gggcacagct gagcgtgaca ctggggaagt       60

caaacccctc tactgcctag gaagatggct agactttaaa gattattttt ttccctttaa      120

ggaaaaagtc tcggagcttt aaaaaaaatt cctttttctc tttttttttc tcccctcttt      180

tttttttttt ctgagccgtg gcttatcccc ccattaagac caatcactga aatcttgttg      240

ctgaaagaaa aaaaagaaag aaagaaaaag aaaagaaaat aatagccaag tgtcttcact      300

gtatctggat gtctacaaat tagagagagg gagagagcga gatttgctcc accagagcgg      360

gcgagagcca ggccagacgc tcgcctttct tttttccgcc tgcatccgcc ctgtgccttc      420

gctgaggctt cgctttgcct tcttcctctc cgcgcacccc cacgggcccg ctggcaaagt      480

ggggtgggga gcgaggcgcg gggggcgggg gccggcgccg cggccagggc tgccgggcgg      540

ccgagcatgg aagaacagca gccggagcct aaaagtcagc gcgactcggg cctcggcgcg      600

gtggcagcgg cggccccgag cggcctcagt ctgagtctga gcccaggagc cagcggcagc      660

agcggcagcg atggagacag cgtgccggtg tccccgcagc cagcgccccc gtcgcctcct      720

gcggcaccct gtctgccgcc cctggcccat cacccgcacc tccccccgca tcccccgccc      780

ccgccgccgc cgccgccgcc gccaccgcag catctcgcgg cgcctgctca ccagccgcag      840

cccgcggccc agctgcaccg caccaccaac tttttcatcg ataacatcct aaggcccgat      900

ttcggttgca aaaaggaaca gcccctgcct cagctcctgg tggcttcggc tgcagccgga      960

ggaggcgcag cagcaggagg aggaagccgc gtggagcgtg accgaggcca gactggtgca     1020

ggtagagacc ccgttcactc tctgggcaca cgagcttcgg gggctgcctc gctcttgtgt     1080

gctccagatg cgaactgtgg cccacccgac ggctcccagc ccgccaccgc tgtcagcgcc     1140

ggcgcatcca aagccgggaa cccggctgct gcggcggccg cggccgcagc agcggctgca     1200

gcggcagtgg cggcagcggc ggcagcagcc tcgaagccct cggacagtgg cggtggtagt     1260

ggaggcaacg cggggagtcc cggggcgcag ggcgccaagt tcccggaaca caaccctgcg     1320

atcctactca tgggttcggc taacggtggg ccggtggtca agactgactc acagcaaccc     1380

ctagtgtggc ccgcctgggt ctactgcaca cgctattcgg accgtccgtc ctctggtcca     1440

cgcaccagga agctaaagaa gaaaaagaac gagaaggaag acaagcggcc gcggacggcg     1500

ttcacggccg agcagctgca gagactcaag gcggagttcc aggcaaaccg ctatatcacg     1560

gagcagcggc gacagaccct cgcccaggag ctcagcctga atgagtccca gatcaagatc     1620

tggttccaaa acaagcgtgc caagatcaag aaagccaccg gcatcaagaa cggcctggcg     1680

ctgcacctca tggcccaggg actgtacaac cactctacca ccacggttca ggacaaagac     1740

gagagcgagt agctgtggcc agctccgggg cccgcggtcc aacggcgccc gtgccacctc     1800

caggctcctc ggggctgccg cttcaccagc cccacgcaga gacgatcgct atggagggag     1860

gcatcaatca gggcgacaga gaaagcgagc aagagaaagc aatcctccga gtggacattc     1920

acataggaac aaaacggttt ttgaaacggg agtaagactc ggacaggtgc tatgggggaa     1980

aaataaacat ctattctcta actcactgta taagatgaaa ctgcgaattc cttaaagctc     2040

tatctagcca aactgctttc gaccgtgtat atatttaatt tcaggtaagg aaaacaaata     2100

tgtgtagcga tctctatttg ctggacattt ttattaatct catttattat tgttataatt     2160

attataatta ttataattat ttttcccctc ctccctacct tgctgcaccc ccccccccca     2220

gcccagtttc gttttcgttg ctcttttcct ttgaatgttt ttgcttctct gggtacctcc     2280

tgcaccccca acgctggccc tggtttctct gggacttttc tttgtgtgag tgtgagtgtg     2340

tttccttgtg tgtctgcccc tcgcctcttc tctacccacc caggattctt ctattggtct     2400

tgtctatccc tcccgtaaat ccccttcctt ttctggagac tccttgagaa atacaacccc     2460

acagactgcg agactgaacc gccgctacaa gccaaagatt ttattatgtt cagaaacctg     2520

tagtctgaaa taaaatgttc actgtgttca tgag                                 2554


<210>  30
<211>  401
<212>  PRT
<213>  Mus musculus

<400>  30

Met Glu Glu Gln Gln Pro Glu Pro Lys Ser Gln Arg Asp Ser Gly Leu 
1               5                   10                  15      


Gly Ala Val Ala Ala Ala Ala Pro Ser Gly Leu Ser Leu Ser Leu Ser 
            20                  25                  30          


Pro Gly Ala Ser Gly Ser Ser Gly Ser Asp Gly Asp Ser Val Pro Val 
        35                  40                  45              


Ser Pro Gln Pro Ala Pro Pro Ser Pro Pro Ala Ala Pro Cys Leu Pro 
    50                  55                  60                  


Pro Leu Ala His His Pro His Leu Pro Pro His Pro Pro Pro Pro Pro 
65                  70                  75                  80  


Pro Pro Pro Pro Pro Pro Pro Gln His Leu Ala Ala Pro Ala His Gln 
                85                  90                  95      


Pro Gln Pro Ala Ala Gln Leu His Arg Thr Thr Asn Phe Phe Ile Asp 
            100                 105                 110         


Asn Ile Leu Arg Pro Asp Phe Gly Cys Lys Lys Glu Gln Pro Leu Pro 
        115                 120                 125             


Gln Leu Leu Val Ala Ser Ala Ala Ala Gly Gly Gly Ala Ala Ala Gly 
    130                 135                 140                 


Gly Gly Ser Arg Val Glu Arg Asp Arg Gly Gln Thr Gly Ala Gly Arg 
145                 150                 155                 160 


Asp Pro Val His Ser Leu Gly Thr Arg Ala Ser Gly Ala Ala Ser Leu 
                165                 170                 175     


Leu Cys Ala Pro Asp Ala Asn Cys Gly Pro Pro Asp Gly Ser Gln Pro 
            180                 185                 190         


Ala Thr Ala Val Ser Ala Gly Ala Ser Lys Ala Gly Asn Pro Ala Ala 
        195                 200                 205             


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Ala Ala 
    210                 215                 220                 


Ala Ala Ala Ala Ser Lys Pro Ser Asp Ser Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Asn Ala Gly Ser Pro Gly Ala Gln Gly Ala Lys Phe Pro Glu His Asn 
                245                 250                 255     


Pro Ala Ile Leu Leu Met Gly Ser Ala Asn Gly Gly Pro Val Val Lys 
            260                 265                 270         


Thr Asp Ser Gln Gln Pro Leu Val Trp Pro Ala Trp Val Tyr Cys Thr 
        275                 280                 285             


Arg Tyr Ser Asp Arg Pro Ser Ser Gly Pro Arg Thr Arg Lys Leu Lys 
    290                 295                 300                 


Lys Lys Lys Asn Glu Lys Glu Asp Lys Arg Pro Arg Thr Ala Phe Thr 
305                 310                 315                 320 


Ala Glu Gln Leu Gln Arg Leu Lys Ala Glu Phe Gln Ala Asn Arg Tyr 
                325                 330                 335     


Ile Thr Glu Gln Arg Arg Gln Thr Leu Ala Gln Glu Leu Ser Leu Asn 
            340                 345                 350         


Glu Ser Gln Ile Lys Ile Trp Phe Gln Asn Lys Arg Ala Lys Ile Lys 
        355                 360                 365             


Lys Ala Thr Gly Ile Lys Asn Gly Leu Ala Leu His Leu Met Ala Gln 
    370                 375                 380                 


Gly Leu Tyr Asn His Ser Thr Thr Thr Val Gln Asp Lys Asp Glu Ser 
385                 390                 395                 400 


Glu 
    


<210>  31
<211>  2962
<212>  DNA
<213>  Homo sapiens

<400>  31
agctcacaga cccataatcc tgcatttctc taacaagttg tttatggagt tgcttctcca       60

tttgcctaca tcccaaaatt cacccctccc gggtttcttc tgccccctcc tgagtcccgg      120

cctgaaggag ggggagggac gcgggtgcgg gcgcgggtgg gggagggcgg acccgacgca      180

cagggccagc gccgaggcgc cccctctccg ccagcggttg acgcccccgg attatttatc      240

cgcaaagtcc cgcgcgcgcc cattgggccg aggcccgagt gtcagcgcga gtcccggctc      300

gccattggct ccgcacacgt gcggccctga ctcacgtgct tccggtttga aggcaaaaag      360

tgtgcctggg tgattttttt tttaagcgag agagtttgtg caaagatccg agctgtcaga      420

gatttgaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaacag cccggcgctg gcggagacgc      480

gctctccctg caaaaaaagc aaaggcgatt aaaggcgctg ccagcctcac gctctgggca      540

cagctgagcg tgacactcgg ggaagtcaaa cccctcacta ctgcctagga agatggctag      600

actttaaata ctattttttt ccctttaaga aaaaaattat tggagctttt tttcttgctt      660

tctttttcct tttctttttc tttttttcct tcattttttt ggccgtggct tactccccat      720

ttaaatcaaa tcattgaatc tggttgcaga aagaaaaaag aaatagccaa gtgtctccat      780

atctggatgt ctacaaatta gagagggaga gacagcgaga tctatctgct agataagaac      840

gagcgatcca ggccagacgc ctgagctttt ttcctgcacc cgccccgtgc cttcgctgag      900

gcttcgcctg cctccttcct ccgcgcaccc ccacgggccg ctggcaaagt ggggtgggga      960

gcgaggcggt gggggcgggg gccggcgcgg cggccggggc ggcggggcgg ccgagcatgg     1020

aagaacagca gccggaacct aaaagtcagc gcgactcggc cctcggcgcg gcggcggcgg     1080

cgactccggg cggcctcagc ctgagcctca gtccgggcgc cagcggcagc agcggcagcg     1140

gcagcgatgg agacagcgtg ccggtgtccc cgcagcctgc gcccccctcg ccgcccgcgg     1200

cgccttgcct gccgcccctg gcccaccacc cgcacctccc cccacacccc ccgcccccgc     1260

cgcctcagca tctcgcggcg cctgctcacc agccgcagcc agcggcccag ctgcaccgca     1320

ccaccaactt tttcatcgac aacatcctga ggccggactt cggctgcaaa aaggagcagc     1380

cgccaccgca gcttctggtg gctgcggcgg ccagaggagg cgcaggagga ggaggccggg     1440

tcgagcgtga cagaggccag actgccgcag gtagagaccc tgtccacccg ttgggcaccc     1500

gggcgccagg cgctgcctcg ctcctgtgcg ccccggacgc gaactgtggc ccacccgacg     1560

gctcccagcc agccgccgcc ggcgcgggcg cgtctaaagc tgggaacccg gctgcggcgg     1620

cggcggcggc cgcggcggca gtggcggcgg cggcggcggc cgcagcagcc aagccctcgg     1680

acaccggtgg cggcggcagt ggaggcggcg cggggagccc cggagcgcag ggcaccaaat     1740

acccggagca cggcaacccg gctatcctac ttatgggctc agccaacggc gggcccgtgg     1800

tcaaaactga ctcgcagcag cctctcgtat ggcccgcctg ggtgtactgc acacgttatt     1860

cggatcgtcc atcctccggt ccgcgcacca ggaagctgaa gaagaagaag aacgagaagg     1920

aggacaagcg gccgcggacc gcgttcacgg ccgagcagct gcagagactc aaggcggagt     1980

tccaggcaaa ccgctacatc acggagcagc ggcggcagac cctggcccag gaactcagcc     2040

tcaacgagtc ccagatcaag atctggttcc agaacaagcg cgccaagatc aagaaagcca     2100

caggcatcaa gaacggcctg gcgctgcacc tcatggccca gggactgtac aaccactcca     2160

ccaccacggt ccaggacaaa gacgagagcg agtagccgcc acaggccggg gccgcgcccg     2220

cgccccctcc cggcaccgcc gccgtcgtct cccggcccct cgctggggga gaaagcatct     2280

gctccaagga gggagggagc gcagggaaaa gagcgagaga gacagaaaga gagcctcaga     2340

atggacaatg acgttgaaac gcagcatttt tgaaaaggga gaaagactcg gacaggtgct     2400

atcgaaaaat aagatccatt ctctattccc agtataaggg acgaaactgc gaactcctta     2460

aagctctatc tagccaaacc gcttacgacc ttgtatatat ttaatttcag gtaaggaaaa     2520

cacatacgtg tagcgatctc tatttgctgg acatttttat taatctcctt tattattatt     2580

gttataatta ttataattat tataattatt ttatcccctc ccccaccgcc tcgctgcccc     2640

cgcccagttt cgttttcgtt gcctttttca tttgaatgtc attgcttctc cggtgcctcc     2700

cgacccgcat cgccggccct ggtttctctg ggacttttct ttgtgtgcga gagtgtgttt     2760

cctttcgtgt ctgcccacct cttctccccc acctcccggg tcccttctgt cggtctgtct     2820

gttctgcccc cctttcgttt tccggagact tgttgagaaa tacgacccca cagactgcga     2880

gactgaaccg ccgctacaag ccaaagattt tattatgttc agaaacctgt agtctgaaat     2940

aaagtgtaca ctgtgctcac ga                                              2962


<210>  32
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Glu Glu Gln Gln Pro Glu Pro Lys Ser Gln Arg Asp Ser Ala Leu 
1               5                   10                  15      


Gly Ala Ala Ala Ala Ala Thr Pro Gly Gly Leu Ser Leu Ser Leu Ser 
            20                  25                  30          


Pro Gly Ala Ser Gly Ser Ser Gly Ser Gly Ser Asp Gly Asp Ser Val 
        35                  40                  45              


Pro Val Ser Pro Gln Pro Ala Pro Pro Ser Pro Pro Ala Ala Pro Cys 
    50                  55                  60                  


Leu Pro Pro Leu Ala His His Pro His Leu Pro Pro His Pro Pro Pro 
65                  70                  75                  80  


Pro Pro Pro Gln His Leu Ala Ala Pro Ala His Gln Pro Gln Pro Ala 
                85                  90                  95      


Ala Gln Leu His Arg Thr Thr Asn Phe Phe Ile Asp Asn Ile Leu Arg 
            100                 105                 110         


Pro Asp Phe Gly Cys Lys Lys Glu Gln Pro Pro Pro Gln Leu Leu Val 
        115                 120                 125             


Ala Ala Ala Ala Arg Gly Gly Ala Gly Gly Gly Gly Arg Val Glu Arg 
    130                 135                 140                 


Asp Arg Gly Gln Thr Ala Ala Gly Arg Asp Pro Val His Pro Leu Gly 
145                 150                 155                 160 


Thr Arg Ala Pro Gly Ala Ala Ser Leu Leu Cys Ala Pro Asp Ala Asn 
                165                 170                 175     


Cys Gly Pro Pro Asp Gly Ser Gln Pro Ala Ala Ala Gly Ala Gly Ala 
            180                 185                 190         


Ser Lys Ala Gly Asn Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        195                 200                 205             


Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Pro Ser Asp Thr Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Ala Gly Ser Pro Gly Ala Gln Gly Thr 
225                 230                 235                 240 


Lys Tyr Pro Glu His Gly Asn Pro Ala Ile Leu Leu Met Gly Ser Ala 
                245                 250                 255     


Asn Gly Gly Pro Val Val Lys Thr Asp Ser Gln Gln Pro Leu Val Trp 
            260                 265                 270         


Pro Ala Trp Val Tyr Cys Thr Arg Tyr Ser Asp Arg Pro Ser Ser Gly 
        275                 280                 285             


Pro Arg Thr Arg Lys Leu Lys Lys Lys Lys Asn Glu Lys Glu Asp Lys 
    290                 295                 300                 


Arg Pro Arg Thr Ala Phe Thr Ala Glu Gln Leu Gln Arg Leu Lys Ala 
305                 310                 315                 320 


Glu Phe Gln Ala Asn Arg Tyr Ile Thr Glu Gln Arg Arg Gln Thr Leu 
                325                 330                 335     


Ala Gln Glu Leu Ser Leu Asn Glu Ser Gln Ile Lys Ile Trp Phe Gln 
            340                 345                 350         


Asn Lys Arg Ala Lys Ile Lys Lys Ala Thr Gly Ile Lys Asn Gly Leu 
        355                 360                 365             


Ala Leu His Leu Met Ala Gln Gly Leu Tyr Asn His Ser Thr Thr Thr 
    370                 375                 380                 


Val Gln Asp Lys Asp Glu Ser Glu 
385                 390         


<210>  33
<211>  2127
<212>  DNA
<213>  Mus musculus

<400>  33
ctgacgacca gggcggccag accacgcgag tcctacgcgc ctcctgaggc cgccccggga       60

cttaactgta acggggaggg gcctccggag cagcggccag cgagttaaag tatgctggga      120

gccgtgaaga tggaagggca cgagccatcc gactggagca gctactacgc ggagcccgag      180

ggctactctt ccgtgagcaa catgaacgcc ggcctgggga tgaatggcat gaacacatac      240

atgagcatgt ccgcggctgc catgggcggc ggttccggca acatgagcgc gggctccatg      300

aacatgtcat cctatgtggg cgctggaatg agcccgtcgc tagctggcat gtccccgggc      360

gccggcgcca tggcgggcat gagcggctca gccggggcgg ccggcgtggc gggcatggga      420

cctcacctga gtccgagtct gagcccgctc gggggacagg cggccggggc catgggtggc      480

cttgccccct acgccaacat gaactcgatg agccccatgt acgggcaggc cggcctgagc      540

cgcgctcggg accccaagac ataccgacgc agctacacac acgccaaacc tccctactcg      600

tacatctcgc tcatcaccat ggccatccag cagagcccca acaagatgct gacgctgagc      660

gagatctatc agtggatcat ggacctcttc cctttctacc ggcagaacca gcagcgctgg      720

cagaactcca tccgccactc tctctccttc aacgactgct ttctcaaggt gccccgctcg      780

ccagacaagc ctggcaaggg ctccttctgg accctgcacc cagactcggg caacatgttc      840

gagaacggct gctacctgcg ccgccagaag cgcttcaagt gtgagaagca actggcactg      900

aaggaagccg cgggtgcggc cagtagcgga ggcaagaaga ccgctcctgg gtcccaggcc      960

tctcaggctc agctcgggga ggccgcgggc tcggcctccg agactccggc gggcaccgag     1020

tccccccatt ccagcgcttc tccgtgtcag gagcacaagc gaggtggcct aagcgagcta     1080

aagggagcac ctgcctctgc gctgagtcct cccgagccgg cgccctcgcc tgggcagcag     1140

cagcaggctg cagcccacct gctgggccca cctcaccacc caggcctgcc accagaggcc     1200

cacctgaagc ccgagcacca ttacgccttc aaccacccct tctctatcaa caacctcatg     1260

tcgtccgagc agcaacatca ccacagccac caccaccatc agccccacaa aatggacctc     1320

aaggcctacg aacaggtcat gcactaccca gggggctatg gttcccccat gccaggcagc     1380

ttggccatgg gcccagtcac gaacaaagcg ggcctggatg cctcgcccct ggctgcagac     1440

acttcctact accaaggagt gtactccagg cctattatga actcatccta agaagatggc     1500

tttcaggccc tgctagctct ggtcactggg gacaagggaa atgagaggct gagtggagac     1560

tttgggagag ctttgaggaa aagtagccac cacacttcag gcctcaaggg agcagtctca     1620

cctgtctgtg tccctaaata gatgggccac agtgatctgt cattctaaat agggaaggga     1680

atggaaatat atatgtatac atataaactt gttttaaagg agcctttggt ctcctctatg     1740

tagactactg cttctcaaga catctgcaga gtttgatttt tgttgttgtt ctctattgct     1800

gttgttgcag aaaagtctga ctttaaaaac aaacaaacaa acaaaaaact tttgtgagtg     1860

acttggtgta aaaccatgta gttttaacag aaaaccagag ggttgtactg atgttgaaaa     1920

gaggaaagaa aaataatgta agagtctggt gtaccggacc aggagaaagg agaaaaacac     1980

atcccattct ggacatggtg aaatccaggt ctcgggtctg atttaattta tggtttctgc     2040

gtgctttatt tatggcttat aaatgtgtgt tctggctaga atggccagaa ttccacaaat     2100

ctatattaaa gtgttattgc cgatttt                                         2127


<210>  34
<211>  459
<212>  PRT
<213>  Mus musculus

<400>  34

Met Leu Gly Ala Val Lys Met Glu Gly His Glu Pro Ser Asp Trp Ser 
1               5                   10                  15      


Ser Tyr Tyr Ala Glu Pro Glu Gly Tyr Ser Ser Val Ser Asn Met Asn 
            20                  25                  30          


Ala Gly Leu Gly Met Asn Gly Met Asn Thr Tyr Met Ser Met Ser Ala 
        35                  40                  45              


Ala Ala Met Gly Gly Gly Ser Gly Asn Met Ser Ala Gly Ser Met Asn 
    50                  55                  60                  


Met Ser Ser Tyr Val Gly Ala Gly Met Ser Pro Ser Leu Ala Gly Met 
65                  70                  75                  80  


Ser Pro Gly Ala Gly Ala Met Ala Gly Met Ser Gly Ser Ala Gly Ala 
                85                  90                  95      


Ala Gly Val Ala Gly Met Gly Pro His Leu Ser Pro Ser Leu Ser Pro 
            100                 105                 110         


Leu Gly Gly Gln Ala Ala Gly Ala Met Gly Gly Leu Ala Pro Tyr Ala 
        115                 120                 125             


Asn Met Asn Ser Met Ser Pro Met Tyr Gly Gln Ala Gly Leu Ser Arg 
    130                 135                 140                 


Ala Arg Asp Pro Lys Thr Tyr Arg Arg Ser Tyr Thr His Ala Lys Pro 
145                 150                 155                 160 


Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met Ala Ile Gln Gln Ser Pro 
                165                 170                 175     


Asn Lys Met Leu Thr Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu 
            180                 185                 190         


Phe Pro Phe Tyr Arg Gln Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg 
        195                 200                 205             


His Ser Leu Ser Phe Asn Asp Cys Phe Leu Lys Val Pro Arg Ser Pro 
    210                 215                 220                 


Asp Lys Pro Gly Lys Gly Ser Phe Trp Thr Leu His Pro Asp Ser Gly 
225                 230                 235                 240 


Asn Met Phe Glu Asn Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys 
                245                 250                 255     


Cys Glu Lys Gln Leu Ala Leu Lys Glu Ala Ala Gly Ala Ala Ser Ser 
            260                 265                 270         


Gly Gly Lys Lys Thr Ala Pro Gly Ser Gln Ala Ser Gln Ala Gln Leu 
        275                 280                 285             


Gly Glu Ala Ala Gly Ser Ala Ser Glu Thr Pro Ala Gly Thr Glu Ser 
    290                 295                 300                 


Pro His Ser Ser Ala Ser Pro Cys Gln Glu His Lys Arg Gly Gly Leu 
305                 310                 315                 320 


Ser Glu Leu Lys Gly Ala Pro Ala Ser Ala Leu Ser Pro Pro Glu Pro 
                325                 330                 335     


Ala Pro Ser Pro Gly Gln Gln Gln Gln Ala Ala Ala His Leu Leu Gly 
            340                 345                 350         


Pro Pro His His Pro Gly Leu Pro Pro Glu Ala His Leu Lys Pro Glu 
        355                 360                 365             


His His Tyr Ala Phe Asn His Pro Phe Ser Ile Asn Asn Leu Met Ser 
    370                 375                 380                 


Ser Glu Gln Gln His His His Ser His His His His Gln Pro His Lys 
385                 390                 395                 400 


Met Asp Leu Lys Ala Tyr Glu Gln Val Met His Tyr Pro Gly Gly Tyr 
                405                 410                 415     


Gly Ser Pro Met Pro Gly Ser Leu Ala Met Gly Pro Val Thr Asn Lys 
            420                 425                 430         


Ala Gly Leu Asp Ala Ser Pro Leu Ala Ala Asp Thr Ser Tyr Tyr Gln 
        435                 440                 445             


Gly Val Tyr Ser Arg Pro Ile Met Asn Ser Ser 
    450                 455                 


<210>  35
<211>  2428
<212>  DNA
<213>  Homo sapiens

<400>  35
cccgcccact tccaactacc gcctccggcc tgcccaggga gagagaggga gtggagccca       60

gggagaggga gcgcgagaga gggagggagg aggggacggt gctttggctg actttttttt      120

aaaagagggt gggggtgggg ggtgattgct ggtcgtttgt tgtggctgtt aaattttaaa      180

ctgccatgca ctcggcttcc agtatgctgg gagcggtgaa gatggaaggg cacgagccgt      240

ccgactggag cagctactat gcagagcccg agggctactc ctccgtgagc aacatgaacg      300

ccggcctggg gatgaacggc atgaacacgt acatgagcat gtcggcggcc gccatgggca      360

gcggctcggg caacatgagc gcgggctcca tgaacatgtc gtcgtacgtg ggcgctggca      420

tgagcccgtc cctggcgggg atgtcccccg gcgcgggcgc catggcgggc atgggcggct      480

cggccggggc ggccggcgtg gcgggcatgg ggccgcactt gagtcccagc ctgagcccgc      540

tcggggggca ggcggccggg gccatgggcg gcctggcccc ctacgccaac atgaactcca      600

tgagccccat gtacgggcag gcgggcctga gccgcgcccg cgaccccaag acctacaggc      660

gcagctacac gcacgcaaag ccgccctact cgtacatctc gctcatcacc atggccatcc      720

agcagagccc caacaagatg ctgacgctga gcgagatcta ccagtggatc atggacctct      780

tccccttcta ccggcagaac cagcagcgct ggcagaactc catccgccac tcgctctcct      840

tcaacgactg tttcctgaag gtgccccgct cgcccgacaa gcccggcaag ggctccttct      900

ggaccctgca ccctgactcg ggcaacatgt tcgagaacgg ctgctacctg cgccgccaga      960

agcgcttcaa gtgcgagaag cagctggcgc tgaaggaggc cgcaggcgcc gccggcagcg     1020

gcaagaaggc ggccgccgga gcccaggcct cacaggctca actcggggag gccgccgggc     1080

cggcctccga gactccggcg ggcaccgagt cgcctcactc gagcgcctcc ccgtgccagg     1140

agcacaagcg agggggcctg ggagagctga aggggacgcc ggctgcggcg ctgagccccc     1200

cagagccggc gccctctccc gggcagcagc agcaggccgc ggcccacctg ctgggcccgc     1260

cccaccaccc gggcctgccg cctgaggccc acctgaagcc ggaacaccac tacgccttca     1320

accacccgtt ctccatcaac aacctcatgt cctcggagca gcagcaccac cacagccacc     1380

accaccacca accccacaaa atggacctca aggcctacga acaggtgatg cactaccccg     1440

gctacggttc ccccatgcct ggcagcttgg ccatgggccc ggtcacgaac aaaacgggcc     1500

tggacgcctc gcccctggcc gcagatacct cctactacca gggggtgtac tcccggccca     1560

ttatgaactc ctcttaagaa gacgacggct tcaggcccgg ctaactctgg caccccggat     1620

cgaggacaag tgagagagca agtgggggtc gagactttgg ggagacggtg ttgcagagac     1680

gcaagggaga agaaatccat aacaccccca ccccaacacc cccaagacag cagtcttctt     1740

cacccgctgc agccgttccg tcccaaacag agggccacac agatacccca cgttctatat     1800

aaggaggaaa acgggaaaga atataaagtt aaaaaaaagc ctccggtttc cactactgtg     1860

tagactcctg cttcttcaag cacctgcaga ttctgatttt tttgttgttg ttgttctcct     1920

ccattgctgt tgttgcaggg aagtcttact taaaaaaaaa aaaaaatttt gtgagtgact     1980

cggtgtaaaa ccatgtagtt ttaacagaac cagagggttg tactattgtt taaaaacagg     2040

aaaaaaaata atgtaagggt ctgttgtaaa tgaccaagaa aaagaaaaaa aaagcattcc     2100

caatcttgac acggtgaaat ccaggtctcg ggtccgatta atttatggtt tctgcgtgct     2160

ttatttatgg cttataaatg tgtattctgg ctgcaagggc cagagttcca caaatctata     2220

ttaaagtgtt atacccggtt ttatcccttg aatcttttct tccagatttt tcttttcttt     2280

acttggctta caaaatatac aggcttggaa attatttcaa gaaggaggga gggataccct     2340

gtctggttgc aggttgtatt ttattttggc ccagggagtg ttgctgtttt cccaacattt     2400

tattaataaa attttcagac ataaaaaa                                        2428


<210>  36
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  36

Met His Ser Ala Ser Ser Met Leu Gly Ala Val Lys Met Glu Gly His 
1               5                   10                  15      


Glu Pro Ser Asp Trp Ser Ser Tyr Tyr Ala Glu Pro Glu Gly Tyr Ser 
            20                  25                  30          


Ser Val Ser Asn Met Asn Ala Gly Leu Gly Met Asn Gly Met Asn Thr 
        35                  40                  45              


Tyr Met Ser Met Ser Ala Ala Ala Met Gly Ser Gly Ser Gly Asn Met 
    50                  55                  60                  


Ser Ala Gly Ser Met Asn Met Ser Ser Tyr Val Gly Ala Gly Met Ser 
65                  70                  75                  80  


Pro Ser Leu Ala Gly Met Ser Pro Gly Ala Gly Ala Met Ala Gly Met 
                85                  90                  95      


Gly Gly Ser Ala Gly Ala Ala Gly Val Ala Gly Met Gly Pro His Leu 
            100                 105                 110         


Ser Pro Ser Leu Ser Pro Leu Gly Gly Gln Ala Ala Gly Ala Met Gly 
        115                 120                 125             


Gly Leu Ala Pro Tyr Ala Asn Met Asn Ser Met Ser Pro Met Tyr Gly 
    130                 135                 140                 


Gln Ala Gly Leu Ser Arg Ala Arg Asp Pro Lys Thr Tyr Arg Arg Ser 
145                 150                 155                 160 


Tyr Thr His Ala Lys Pro Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met 
                165                 170                 175     


Ala Ile Gln Gln Ser Pro Asn Lys Met Leu Thr Leu Ser Glu Ile Tyr 
            180                 185                 190         


Gln Trp Ile Met Asp Leu Phe Pro Phe Tyr Arg Gln Asn Gln Gln Arg 
        195                 200                 205             


Trp Gln Asn Ser Ile Arg His Ser Leu Ser Phe Asn Asp Cys Phe Leu 
    210                 215                 220                 


Lys Val Pro Arg Ser Pro Asp Lys Pro Gly Lys Gly Ser Phe Trp Thr 
225                 230                 235                 240 


Leu His Pro Asp Ser Gly Asn Met Phe Glu Asn Gly Cys Tyr Leu Arg 
                245                 250                 255     


Arg Gln Lys Arg Phe Lys Cys Glu Lys Gln Leu Ala Leu Lys Glu Ala 
            260                 265                 270         


Ala Gly Ala Ala Gly Ser Gly Lys Lys Ala Ala Ala Gly Ala Gln Ala 
        275                 280                 285             


Ser Gln Ala Gln Leu Gly Glu Ala Ala Gly Pro Ala Ser Glu Thr Pro 
    290                 295                 300                 


Ala Gly Thr Glu Ser Pro His Ser Ser Ala Ser Pro Cys Gln Glu His 
305                 310                 315                 320 


Lys Arg Gly Gly Leu Gly Glu Leu Lys Gly Thr Pro Ala Ala Ala Leu 
                325                 330                 335     


Ser Pro Pro Glu Pro Ala Pro Ser Pro Gly Gln Gln Gln Gln Ala Ala 
            340                 345                 350         


Ala His Leu Leu Gly Pro Pro His His Pro Gly Leu Pro Pro Glu Ala 
        355                 360                 365             


His Leu Lys Pro Glu His His Tyr Ala Phe Asn His Pro Phe Ser Ile 
    370                 375                 380                 


Asn Asn Leu Met Ser Ser Glu Gln Gln His His His Ser His His His 
385                 390                 395                 400 


His Gln Pro His Lys Met Asp Leu Lys Ala Tyr Glu Gln Val Met His 
                405                 410                 415     


Tyr Pro Gly Tyr Gly Ser Pro Met Pro Gly Ser Leu Ala Met Gly Pro 
            420                 425                 430         


Val Thr Asn Lys Thr Gly Leu Asp Ala Ser Pro Leu Ala Ala Asp Thr 
        435                 440                 445             


Ser Tyr Tyr Gln Gly Val Tyr Ser Arg Pro Ile Met Asn Ser Ser 
    450                 455                 460             


<210>  37
<211>  1338
<212>  DNA
<213>  Mus musculus

<400>  37
atggcgaccg cagcgtctaa ccactacagc ctgctcacct ccagcgcctc catcgtacat       60

gccgagccgc ctggcggcat gcagcagggc gcagggggct accgcgaggc gcagagcctg      120

gtgcagggcg actacggcgc gctgcagagc aacgggcacc cgctcagcca cgctcaccag      180

tggatcaccg cgctgtccca cggcggcggc ggcgggggcg gcggcggcgg tggaggaggc      240

gggggaggcg gcgggggagg cggcgacggc tccccgtggt ccaccagccc cctaggccag      300

ccggacatca agccctcggt ggtggtacag cagggtggcc gaggcgacga gctgcacggg      360

ccaggagcgc tgcagcaaca gcatcaacag caacagcaac agcagcagca gcagcagcag      420

cagcagcagc agcaacagca gcagcaacaa cagcgaccgc cacatctggt gcaccacgct      480

gccaaccacc atcccgggcc cggggcatgg cggagtgcgg cggctgcagc tcacctccct      540

ccctccatgg gagcttccaa cggcggtttg ctctattcgc agccgagctt cacggtgaac      600

ggcatgctgg gcgcaggagg gcagccggct gggctgcacc accacggcct gagggacgcc      660

cacgatgagc cacaccatgc agaccaccac ccgcatccgc actctcaccc acaccagcaa      720

ccgcccccgc cacctccccc acaaggccca ccgggccacc caggcgcgca ccacgacccg      780

cactcggacg aggacacgcc gacctcagac gacctggagc agttcgccaa gcaattcaag      840

cagaggcgga tcaaactcgg atttactcaa gcagacgtgg ggctggcgct tggcaccctg      900

tacggcaacg tgttctcgca gaccaccatc tgcaggtttg aggccctgca gctgagcttc      960

aagaacatgt gcaagctgaa gcctttgttg aacaagtggt tggaagaggc agactcatcc     1020

tcgggcagcc ccaccagcat agacaagatc gcagcgcaag ggcgcaaacg gaaaaagcgg     1080

acctccatcg aggtgagcgt caagggggct ctggagagcc atttcctcaa atgccctaag     1140

ccctcggccc aggagatcac ctccctcgcg gacagcttac agctggagaa ggaggtggtg     1200

agagtttggt tttgtaacag gagacagaaa gagaaaagga tgacccctcc cggagggact     1260

ctgccgggcg ccgaggatgt gtatgggggt agtagggaca cgccaccaca ccacggggtg     1320

cagacgcccg tccagtga                                                   1338


<210>  38
<211>  445
<212>  PRT
<213>  Mus musculus

<400>  38

Met Ala Thr Ala Ala Ser Asn His Tyr Ser Leu Leu Thr Ser Ser Ala 
1               5                   10                  15      


Ser Ile Val His Ala Glu Pro Pro Gly Gly Met Gln Gln Gly Ala Gly 
            20                  25                  30          


Gly Tyr Arg Glu Ala Gln Ser Leu Val Gln Gly Asp Tyr Gly Ala Leu 
        35                  40                  45              


Gln Ser Asn Gly His Pro Leu Ser His Ala His Gln Trp Ile Thr Ala 
    50                  55                  60                  


Leu Ser His Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Asp Gly Ser Pro Trp Ser Thr Ser 
                85                  90                  95      


Pro Leu Gly Gln Pro Asp Ile Lys Pro Ser Val Val Val Gln Gln Gly 
            100                 105                 110         


Gly Arg Gly Asp Glu Leu His Gly Pro Gly Ala Leu Gln Gln Gln His 
        115                 120                 125             


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    130                 135                 140                 


Gln Gln Gln Gln Gln Gln Gln Arg Pro Pro His Leu Val His His Ala 
145                 150                 155                 160 


Ala Asn His His Pro Gly Pro Gly Ala Trp Arg Ser Ala Ala Ala Ala 
                165                 170                 175     


Ala His Leu Pro Pro Ser Met Gly Ala Ser Asn Gly Gly Leu Leu Tyr 
            180                 185                 190         


Ser Gln Pro Ser Phe Thr Val Asn Gly Met Leu Gly Ala Gly Gly Gln 
        195                 200                 205             


Pro Ala Gly Leu His His His Gly Leu Arg Asp Ala His Asp Glu Pro 
    210                 215                 220                 


His His Ala Asp His His Pro His Pro His Ser His Pro His Gln Gln 
225                 230                 235                 240 


Pro Pro Pro Pro Pro Pro Pro Gln Gly Pro Pro Gly His Pro Gly Ala 
                245                 250                 255     


His His Asp Pro His Ser Asp Glu Asp Thr Pro Thr Ser Asp Asp Leu 
            260                 265                 270         


Glu Gln Phe Ala Lys Gln Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe 
        275                 280                 285             


Thr Gln Ala Asp Val Gly Leu Ala Leu Gly Thr Leu Tyr Gly Asn Val 
    290                 295                 300                 


Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu Ser Phe 
305                 310                 315                 320 


Lys Asn Met Cys Lys Leu Lys Pro Leu Leu Asn Lys Trp Leu Glu Glu 
                325                 330                 335     


Ala Asp Ser Ser Ser Gly Ser Pro Thr Ser Ile Asp Lys Ile Ala Ala 
            340                 345                 350         


Gln Gly Arg Lys Arg Lys Lys Arg Thr Ser Ile Glu Val Ser Val Lys 
        355                 360                 365             


Gly Ala Leu Glu Ser His Phe Leu Lys Cys Pro Lys Pro Ser Ala Gln 
    370                 375                 380                 


Glu Ile Thr Ser Leu Ala Asp Ser Leu Gln Leu Glu Lys Glu Val Val 
385                 390                 395                 400 


Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Met Thr Pro 
                405                 410                 415     


Pro Gly Gly Thr Leu Pro Gly Ala Glu Asp Val Tyr Gly Gly Ser Arg 
            420                 425                 430         


Asp Thr Pro Pro His His Gly Val Gln Thr Pro Val Gln 
        435                 440                 445 


<210>  39
<211>  1332
<212>  DNA
<213>  Homo sapiens

<400>  39
atggcgaccg cagcgtctaa ccactacagc ctgctcacct ccagcgcctc catcgtgcac       60

gccgagccgc ccggcggcat gcagcagggc gcggggggct accgcgaagc gcagagcctg      120

gtgcagggcg actacggcgc tctgcagagc aacggacacc cgctcagcca cgctcaccag      180

tggatcaccg cgctgtccca cggcggcggc ggcgggggcg gtggcggcgg cggggggggc      240

gggggcggcg gcgggggcgg cggcgacggc tccccgtggt ccaccagccc cctgggccag      300

ccggacatca agccctcggt ggtggtgcag cagggcggcc gcggagacga gctgcacggg      360

ccaggcgccc tgcagcagca gcatcagcag cagcaacagc aacagcagca gcaacagcag      420

caacagcagc agcagcagca gcaacagcgg ccgccgcatc tggtgcacca cgccgctaac      480

caccacccgg gacccggggc atggcggagc gcggcggctg cagcgcacct cccaccctcc      540

atgggagcgt ccaacggcgg cttgctctac tcgcagccca gcttcacggt gaacggcatg      600

ctgggcgccg gcgggcagcc ggccgggctg caccaccacg gcctgcggga cgcgcacgac      660

gagccacacc atgccgacca ccacccgcac ccgcactcgc acccacacca gcagccgccg      720

cccccgccgc ccccgcaggg tccgcctggc cacccaggcg cgcaccacga cccgcactcg      780

gacgaggaca cgccgacctc ggacgacctg gagcagttcg ccaagcagtt caagcagcgg      840

cggatcaaac tgggatttac ccaagcggac gtggggctgg ctctgggcac cctgtatggc      900

aacgtgttct cgcagaccac catctgcagg tttgaggccc tgcagctgag cttcaagaac      960

atgtgcaagc tgaagccttt gttgaacaag tggttggagg aggcggactc gtcctcgggc     1020

agccccacga gcatagacaa gatcgcagcg caagggcgca agcggaaaaa gcggacctcc     1080

atcgaggtga gcgtcaaggg ggctctggag agccatttcc tcaaatgccc caagccctcg     1140

gcccaggaga tcacctccct cgcggacagc ttacagctgg agaaggaggt ggtgagagtt     1200

tggttttgta acaggagaca gaaagagaaa aggatgaccc ctcccggagg gactctgccg     1260

ggcgccgagg atgtgtacgg ggggagtagg gacactccac cacaccacgg ggtgcagacg     1320

cccgtccagt ga                                                         1332


<210>  40
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ala Thr Ala Ala Ser Asn His Tyr Ser Leu Leu Thr Ser Ser Ala 
1               5                   10                  15      


Ser Ile Val His Ala Glu Pro Pro Gly Gly Met Gln Gln Gly Ala Gly 
            20                  25                  30          


Gly Tyr Arg Glu Ala Gln Ser Leu Val Gln Gly Asp Tyr Gly Ala Leu 
        35                  40                  45              


Gln Ser Asn Gly His Pro Leu Ser His Ala His Gln Trp Ile Thr Ala 
    50                  55                  60                  


Leu Ser His Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Asp Gly Ser Pro Trp Ser Thr Ser 
                85                  90                  95      


Pro Leu Gly Gln Pro Asp Ile Lys Pro Ser Val Val Val Gln Gln Gly 
            100                 105                 110         


Gly Arg Gly Asp Glu Leu His Gly Pro Gly Ala Leu Gln Gln Gln His 
        115                 120                 125             


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    130                 135                 140                 


Gln Gln Gln Gln Gln Arg Pro Pro His Leu Val His His Ala Ala Asn 
145                 150                 155                 160 


His His Pro Gly Pro Gly Ala Trp Arg Ser Ala Ala Ala Ala Ala His 
                165                 170                 175     


Leu Pro Pro Ser Met Gly Ala Ser Asn Gly Gly Leu Leu Tyr Ser Gln 
            180                 185                 190         


Pro Ser Phe Thr Val Asn Gly Met Leu Gly Ala Gly Gly Gln Pro Ala 
        195                 200                 205             


Gly Leu His His His Gly Leu Arg Asp Ala His Asp Glu Pro His His 
    210                 215                 220                 


Ala Asp His His Pro His Pro His Ser His Pro His Gln Gln Pro Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Pro Gln Gly Pro Pro Gly His Pro Gly Ala His His 
                245                 250                 255     


Asp Pro His Ser Asp Glu Asp Thr Pro Thr Ser Asp Asp Leu Glu Gln 
            260                 265                 270         


Phe Ala Lys Gln Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe Thr Gln 
        275                 280                 285             


Ala Asp Val Gly Leu Ala Leu Gly Thr Leu Tyr Gly Asn Val Phe Ser 
    290                 295                 300                 


Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu Ser Phe Lys Asn 
305                 310                 315                 320 


Met Cys Lys Leu Lys Pro Leu Leu Asn Lys Trp Leu Glu Glu Ala Asp 
                325                 330                 335     


Ser Ser Ser Gly Ser Pro Thr Ser Ile Asp Lys Ile Ala Ala Gln Gly 
            340                 345                 350         


Arg Lys Arg Lys Lys Arg Thr Ser Ile Glu Val Ser Val Lys Gly Ala 
        355                 360                 365             


Leu Glu Ser His Phe Leu Lys Cys Pro Lys Pro Ser Ala Gln Glu Ile 
    370                 375                 380                 


Thr Ser Leu Ala Asp Ser Leu Gln Leu Glu Lys Glu Val Val Arg Val 
385                 390                 395                 400 


Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Met Thr Pro Pro Gly 
                405                 410                 415     


Gly Thr Leu Pro Gly Ala Glu Asp Val Tyr Gly Gly Ser Arg Asp Thr 
            420                 425                 430         


Pro Pro His His Gly Val Gln Thr Pro Val Gln 
        435                 440             


<210>  41
<211>  3564
<212>  DNA
<213>  Mus musculus

<400>  41
atggacgtgg actctgagga gaagcgccat cgcacacggt ccaaaggggt tcgagttcct       60

gtggagccag ccatacaaga gctgttcagc tgtcccactc caggctgcga cggcagtggt      120

cacgtcagtg gcaaatatgc acgacacaga agtgtatatg gttgtccctt ggctaaaaaa      180

agaaaaacgc aagataaaca gccccaagaa cctgctccca agcgaaaacc atttgcagta      240

aaagcagata gttcctcagt agacgaatgt tatgagagtg atggtactga agacatggat      300

gataaggagg aagatgatga tgaggagttc tctgaagaca atgatgagca aggggatgat      360

gacgacgaag atgaggtgga tcgggaagac gaggaggaga tcgaggagga agatgatgaa      420

gaagatgatg atgatgaaga tggtgacgat gtagaagagg aagaagagga tgatgatgaa      480

gaggaggaag aagaggaaga ggaagaagaa aatgaagacc atcaaatgag ttgtactcga      540

ataatgcagg acacagacaa ggatgataac aacaatgatg agtatgataa ctatgatgaa      600

ctggtagcta agtcgctatt aaatcttggc aaaattgctg aggatgcagc ataccgagcc      660

aggactgaat cagagatgaa cagcaatacc tccaatagtc tggaggacga tagtgacaaa      720

aacgaaaacc tcggtcggaa aagcgaactg agtctagact tagacagtga tgttgttaga      780

gaaacagtgg actcccttaa gctgttagca caaggacatg gtgttgtgct atcagagaat      840

atcagtgaca gaagttatgc tgaggggatg tcacagcagg acagtagaaa tatgaactat      900

gtcatgctag ggaagcccat gaacaatgga ctcatggaga agatggtgga ggagagtgat      960

gaggaagtgt gtctaagtag tctagagtgc ctgaggaacc agtgctttga cctggccagg     1020

aaactcagcg agaccaaccc acaggacagg agtcagccac ccaacatgag tgtgcgccaa     1080

catgtccggc aagaggacga cttccctggg aggacgccag acaggagcta ctcggatatg     1140

atgaacctta tgcggctgga ggagcagctc agtcccaggt ctagaacgtt ctccagctgt     1200

gccaaggagg atgggtgtca tgagagggat gatgacacca cctcagtgaa ctcagacagg     1260

tctgaggaag tgtttgacat gaccaagggc aacctgactc tgctagagaa agccattgcc     1320

ttggagacag agagagccaa ggccatgcgg gagaagatgg ccatggatgc tgggagaagg     1380

gataacctga gatcctatga ggaccagtct ccaagacagc tggctgggga agacagaaaa     1440

tccaaatcca gtgacagcca tgtcaaaaag ccatactatg gtaaagatcc ctcaagaaca     1500

gaaaagagag agagcaagtg tccaaccccc gggtgtgatg gaaccggcca cgtaactggg     1560

ctttacccgc atcaccgcag tctgtctgga tgcccgcaca aagatagggt ccctccagaa     1620

attcttgcca tgcatgaaaa tgttctcaag tgtcccactc caggctgcac agggcgaggg     1680

catgtgaata gcaacaggaa ctcgcacaga agcctctctg gatgccccat tgctgctgca     1740

gaaaaactgg caaaggccca agagaaacac cagagctgtg atgtgtccaa atccaaccag     1800

gcctcagacc gagtcctcag gccaatgtgc tttgtcaaac agcttgagat tcctcagtat     1860

ggctacagaa acaatgttcc cacaaccaca ccacgctcca acctggccaa ggagcttgag     1920

aaatactcca agacttcgtt tgagtacaac agttacgaca accatactta tggcaaaaga     1980

gccatagctc ccaaggtgca aaccagggac atatccccca aaggatatga cgatgccaag     2040

cggtactgca agaatgccag ccccagcagc agcaccacca gcagctatgc acctagcagc     2100

agcagcaacc tcagctgtgg tggtggcagc agcgccagta gcacgtgtag caagagcagc     2160

tttgactaca cacatgacat ggaggccgca cacatggcag ccacagccat tctcaacctg     2220

tccacacgtt gtcgtgaaat gccacagaac ctgtccacca agccacagga cctgtgtact     2280

gcccggaacc cagacatgga ggtggatgag aatggcaccc tggacctgag catgaacaag     2340

cagaggcctc gagacagctg ctgcccagtc ctgacacccc tggaacccat gtctccgcag     2400

cagcaggccg tgatgagcag ccgatgcttc cagctgagcg agggggattg ctgggacttg     2460

cctgtagact acaccaaaat gaagcctcgg agggtagatg aggatgagcc caaagagatt     2520

accccagaag acttggaccc attccaggag gctctggaag aaagacggta tccaggggag     2580

gtgaccatcc caagccccaa acccaagtac cctcagtgca aggaaagcaa aaaggactta     2640

ataactctgt ctggctgccc cctggcggac aaaagcattc gaagtatgct ggccaccagt     2700

tcccaagagc tcaagtgccc cacccctggc tgtgacggtt ctggacacat cactggcaat     2760

tacgcttctc atcgaagcct ttctgggtgc ccgagagcaa agaagagtgg catccggata     2820

gcacagagca aagaggacaa ggaagaccag gagccaatca ggtgtccggt acctggctgt     2880

gacggtcagg gacacatcac tgggaagtat gcatcccacc gcagcgcctc cgggtgtccc     2940

ttggcagcca agaggcagaa agatgggtac cttaatggct cccagttctc ctggaagtcg     3000

gtcaagacgg agggcatgtc ctgccctacc cccgggtgtg atgggtcagg acacgtcagt     3060

ggcagcttcc tcacacaccg cagcttgtca ggatgtccaa gagccacatc agcaatgaag     3120

aaagcaaagc tgtctggaga acagatgttg actatcaagc agcgagccag caacggtata     3180

gaaaatgatg aagaaatcaa gcagttagat gaagagatca aggagcttaa tgagtccaat     3240

tcccagatgg aggctgacat gatcaaactc agaactcaga tcaccacaat ggagagcaac     3300

ctgaagacga ttgaggagga gaacaaagtc attgaacagc agaatgagtc gctcttgcac     3360

gagttggcca acctgagcca gtccctgatc cacagcctcg ccaacatcca gctgcctcac     3420

atggatccaa tcaatgaaca aaattttgat gcttacgtga ctactttgac ggaaatgtat     3480

acaaatcaag atcgttatca gagtccagaa aataaagccc tactggaaaa tataaagcag     3540

gctgtgagag gaattcaggt ctga                                            3564


<210>  42
<211>  1187
<212>  PRT
<213>  Mus musculus

<400>  42

Met Asp Val Asp Ser Glu Glu Lys Arg His Arg Thr Arg Ser Lys Gly 
1               5                   10                  15      


Val Arg Val Pro Val Glu Pro Ala Ile Gln Glu Leu Phe Ser Cys Pro 
            20                  25                  30          


Thr Pro Gly Cys Asp Gly Ser Gly His Val Ser Gly Lys Tyr Ala Arg 
        35                  40                  45              


His Arg Ser Val Tyr Gly Cys Pro Leu Ala Lys Lys Arg Lys Thr Gln 
    50                  55                  60                  


Asp Lys Gln Pro Gln Glu Pro Ala Pro Lys Arg Lys Pro Phe Ala Val 
65                  70                  75                  80  


Lys Ala Asp Ser Ser Ser Val Asp Glu Cys Tyr Glu Ser Asp Gly Thr 
                85                  90                  95      


Glu Asp Met Asp Asp Lys Glu Glu Asp Asp Asp Glu Glu Phe Ser Glu 
            100                 105                 110         


Asp Asn Asp Glu Gln Gly Asp Asp Asp Asp Glu Asp Glu Val Asp Arg 
        115                 120                 125             


Glu Asp Glu Glu Glu Ile Glu Glu Glu Asp Asp Glu Glu Asp Asp Asp 
    130                 135                 140                 


Asp Glu Asp Gly Asp Asp Val Glu Glu Glu Glu Glu Asp Asp Asp Glu 
145                 150                 155                 160 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asn Glu Asp His Gln Met 
                165                 170                 175     


Ser Cys Thr Arg Ile Met Gln Asp Thr Asp Lys Asp Asp Asn Asn Asn 
            180                 185                 190         


Asp Glu Tyr Asp Asn Tyr Asp Glu Leu Val Ala Lys Ser Leu Leu Asn 
        195                 200                 205             


Leu Gly Lys Ile Ala Glu Asp Ala Ala Tyr Arg Ala Arg Thr Glu Ser 
    210                 215                 220                 


Glu Met Asn Ser Asn Thr Ser Asn Ser Leu Glu Asp Asp Ser Asp Lys 
225                 230                 235                 240 


Asn Glu Asn Leu Gly Arg Lys Ser Glu Leu Ser Leu Asp Leu Asp Ser 
                245                 250                 255     


Asp Val Val Arg Glu Thr Val Asp Ser Leu Lys Leu Leu Ala Gln Gly 
            260                 265                 270         


His Gly Val Val Leu Ser Glu Asn Ile Ser Asp Arg Ser Tyr Ala Glu 
        275                 280                 285             


Gly Met Ser Gln Gln Asp Ser Arg Asn Met Asn Tyr Val Met Leu Gly 
    290                 295                 300                 


Lys Pro Met Asn Asn Gly Leu Met Glu Lys Met Val Glu Glu Ser Asp 
305                 310                 315                 320 


Glu Glu Val Cys Leu Ser Ser Leu Glu Cys Leu Arg Asn Gln Cys Phe 
                325                 330                 335     


Asp Leu Ala Arg Lys Leu Ser Glu Thr Asn Pro Gln Asp Arg Ser Gln 
            340                 345                 350         


Pro Pro Asn Met Ser Val Arg Gln His Val Arg Gln Glu Asp Asp Phe 
        355                 360                 365             


Pro Gly Arg Thr Pro Asp Arg Ser Tyr Ser Asp Met Met Asn Leu Met 
    370                 375                 380                 


Arg Leu Glu Glu Gln Leu Ser Pro Arg Ser Arg Thr Phe Ser Ser Cys 
385                 390                 395                 400 


Ala Lys Glu Asp Gly Cys His Glu Arg Asp Asp Asp Thr Thr Ser Val 
                405                 410                 415     


Asn Ser Asp Arg Ser Glu Glu Val Phe Asp Met Thr Lys Gly Asn Leu 
            420                 425                 430         


Thr Leu Leu Glu Lys Ala Ile Ala Leu Glu Thr Glu Arg Ala Lys Ala 
        435                 440                 445             


Met Arg Glu Lys Met Ala Met Asp Ala Gly Arg Arg Asp Asn Leu Arg 
    450                 455                 460                 


Ser Tyr Glu Asp Gln Ser Pro Arg Gln Leu Ala Gly Glu Asp Arg Lys 
465                 470                 475                 480 


Ser Lys Ser Ser Asp Ser His Val Lys Lys Pro Tyr Tyr Gly Lys Asp 
                485                 490                 495     


Pro Ser Arg Thr Glu Lys Arg Glu Ser Lys Cys Pro Thr Pro Gly Cys 
            500                 505                 510         


Asp Gly Thr Gly His Val Thr Gly Leu Tyr Pro His His Arg Ser Leu 
        515                 520                 525             


Ser Gly Cys Pro His Lys Asp Arg Val Pro Pro Glu Ile Leu Ala Met 
    530                 535                 540                 


His Glu Asn Val Leu Lys Cys Pro Thr Pro Gly Cys Thr Gly Arg Gly 
545                 550                 555                 560 


His Val Asn Ser Asn Arg Asn Ser His Arg Ser Leu Ser Gly Cys Pro 
                565                 570                 575     


Ile Ala Ala Ala Glu Lys Leu Ala Lys Ala Gln Glu Lys His Gln Ser 
            580                 585                 590         


Cys Asp Val Ser Lys Ser Asn Gln Ala Ser Asp Arg Val Leu Arg Pro 
        595                 600                 605             


Met Cys Phe Val Lys Gln Leu Glu Ile Pro Gln Tyr Gly Tyr Arg Asn 
    610                 615                 620                 


Asn Val Pro Thr Thr Thr Pro Arg Ser Asn Leu Ala Lys Glu Leu Glu 
625                 630                 635                 640 


Lys Tyr Ser Lys Thr Ser Phe Glu Tyr Asn Ser Tyr Asp Asn His Thr 
                645                 650                 655     


Tyr Gly Lys Arg Ala Ile Ala Pro Lys Val Gln Thr Arg Asp Ile Ser 
            660                 665                 670         


Pro Lys Gly Tyr Asp Asp Ala Lys Arg Tyr Cys Lys Asn Ala Ser Pro 
        675                 680                 685             


Ser Ser Ser Thr Thr Ser Ser Tyr Ala Pro Ser Ser Ser Ser Asn Leu 
    690                 695                 700                 


Ser Cys Gly Gly Gly Ser Ser Ala Ser Ser Thr Cys Ser Lys Ser Ser 
705                 710                 715                 720 


Phe Asp Tyr Thr His Asp Met Glu Ala Ala His Met Ala Ala Thr Ala 
                725                 730                 735     


Ile Leu Asn Leu Ser Thr Arg Cys Arg Glu Met Pro Gln Asn Leu Ser 
            740                 745                 750         


Thr Lys Pro Gln Asp Leu Cys Thr Ala Arg Asn Pro Asp Met Glu Val 
        755                 760                 765             


Asp Glu Asn Gly Thr Leu Asp Leu Ser Met Asn Lys Gln Arg Pro Arg 
    770                 775                 780                 


Asp Ser Cys Cys Pro Val Leu Thr Pro Leu Glu Pro Met Ser Pro Gln 
785                 790                 795                 800 


Gln Gln Ala Val Met Ser Ser Arg Cys Phe Gln Leu Ser Glu Gly Asp 
                805                 810                 815     


Cys Trp Asp Leu Pro Val Asp Tyr Thr Lys Met Lys Pro Arg Arg Val 
            820                 825                 830         


Asp Glu Asp Glu Pro Lys Glu Ile Thr Pro Glu Asp Leu Asp Pro Phe 
        835                 840                 845             


Gln Glu Ala Leu Glu Glu Arg Arg Tyr Pro Gly Glu Val Thr Ile Pro 
    850                 855                 860                 


Ser Pro Lys Pro Lys Tyr Pro Gln Cys Lys Glu Ser Lys Lys Asp Leu 
865                 870                 875                 880 


Ile Thr Leu Ser Gly Cys Pro Leu Ala Asp Lys Ser Ile Arg Ser Met 
                885                 890                 895     


Leu Ala Thr Ser Ser Gln Glu Leu Lys Cys Pro Thr Pro Gly Cys Asp 
            900                 905                 910         


Gly Ser Gly His Ile Thr Gly Asn Tyr Ala Ser His Arg Ser Leu Ser 
        915                 920                 925             


Gly Cys Pro Arg Ala Lys Lys Ser Gly Ile Arg Ile Ala Gln Ser Lys 
    930                 935                 940                 


Glu Asp Lys Glu Asp Gln Glu Pro Ile Arg Cys Pro Val Pro Gly Cys 
945                 950                 955                 960 


Asp Gly Gln Gly His Ile Thr Gly Lys Tyr Ala Ser His Arg Ser Ala 
                965                 970                 975     


Ser Gly Cys Pro Leu Ala Ala Lys Arg Gln Lys Asp Gly Tyr Leu Asn 
            980                 985                 990         


Gly Ser Gln Phe Ser Trp Lys Ser  Val Lys Thr Glu Gly  Met Ser Cys 
        995                 1000                 1005             


Pro Thr  Pro Gly Cys Asp Gly  Ser Gly His Val Ser  Gly Ser Phe 
    1010                 1015                 1020             


Leu Thr  His Arg Ser Leu Ser  Gly Cys Pro Arg Ala  Thr Ser Ala 
    1025                 1030                 1035             


Met Lys  Lys Ala Lys Leu Ser  Gly Glu Gln Met Leu  Thr Ile Lys 
    1040                 1045                 1050             


Gln Arg  Ala Ser Asn Gly Ile  Glu Asn Asp Glu Glu  Ile Lys Gln 
    1055                 1060                 1065             


Leu Asp  Glu Glu Ile Lys Glu  Leu Asn Glu Ser Asn  Ser Gln Met 
    1070                 1075                 1080             


Glu Ala  Asp Met Ile Lys Leu  Arg Thr Gln Ile Thr  Thr Met Glu 
    1085                 1090                 1095             


Ser Asn  Leu Lys Thr Ile Glu  Glu Glu Asn Lys Val  Ile Glu Gln 
    1100                 1105                 1110             


Gln Asn  Glu Ser Leu Leu His  Glu Leu Ala Asn Leu  Ser Gln Ser 
    1115                 1120                 1125             


Leu Ile  His Ser Leu Ala Asn  Ile Gln Leu Pro His  Met Asp Pro 
    1130                 1135                 1140             


Ile Asn  Glu Gln Asn Phe Asp  Ala Tyr Val Thr Thr  Leu Thr Glu 
    1145                 1150                 1155             


Met Tyr  Thr Asn Gln Asp Arg  Tyr Gln Ser Pro Glu  Asn Lys Ala 
    1160                 1165                 1170             


Leu Leu  Glu Asn Ile Lys Gln  Ala Val Arg Gly Ile  Gln Val 
    1175                 1180                 1185         


<210>  43
<211>  3555
<212>  DNA
<213>  Homo sapiens

<400>  43
atggaggtgg acaccgagga gaagcggcat cgcacgcggt ccaaaggggt tcgagttccc       60

gtggaaccag ccatacaaga gctgttcagc tgtcccaccc ctggctgtga cggcagtggt      120

catgtcagtg gcaaatatgc aagacacaga agtgtatatg gttgtccctt ggcgaaaaaa      180

agaaaaacac aagataaaca gccccaggaa cctgctccta aacgaaagcc atttgccgtg      240

aaagcagaca gctcctcagt ggatgagtgt gacgacagtg atgggactga ggacatggat      300

gagaaggagg aggatgaggg ggaggagtac tccgaggaca atgacgagcc aggggatgag      360

gacgaggagg acgaggaggg ggaccgggag gaggaggagg agatcgagga ggaggatgag      420

gacgatgacg aggatggaga agatgtggag gatgaagaag aggaagagga ggaggaggag      480

gaggaggaag aggaagaaga aaacgaagac catcaaatga attgtcacaa tactcgaata      540

atgcaagaca cagaaaagga tgataacaat aatgacgaat atgacaatta cgatgaactg      600

gtggccaagt cattgttaaa cctcggcaaa atcgctgagg atgcagccta ccgggccagg      660

actgagtcag aaatgaacag caatacctcc aatagtctgg aagacgatag tgacaaaaac      720

gaaaacctgg gtcggaaaag tgagttgagt ttagacttag acagtgatgt tgttagagaa      780

acagtggact cccttaaact attagcccaa ggacacggtg ttgtgctctc agaaaacatg      840

aatgacagaa attatgcaga cagcatgtcg cagcaagaca gtagaaatat gaattacgtc      900

atgttgggga agcccatgaa caacggactc atggaaaaga tggtggagga gagcgatgag      960

gaggtgtgtc tgagcagtct ggagtgtttg aggaatcagt gcttcgacct ggccaggaag     1020

ctcagtgaga ccaacccgca ggagaggaat ccgcagcaga acatgaacat ccgtcagcat     1080

gtccggccag aagaggactt ccccggaagg acgccggaca gaaactactc ggacatgctg     1140

aacctcatgc ggctggagga gcagttgagc ccccggtcga gagtgtttgc cagctgtgcg     1200

aaggaggatg ggtgtcatga gcgggacgac gataccacct ctgtgaactc ggacaggtct     1260

gaagaggtgt tcgacatgac caaggggaac ctgaccctgc tggagaaagc catcgctttg     1320

gaaacggaaa gagcaaaggc catgagggag aagatggcca tggaagctgg gaggagggac     1380

aatatgaggt catatgagga ccagtctccg agacaacttc ccggggagga cagaaagcct     1440

aaatccagtg acagccatgt caaaaagcca tactatgatc cctcaagaac agaaaagaaa     1500

gagagcaagt gtccaacccc cgggtgtgat ggaaccggcc acgtaactgg gctgtaccca     1560

catcaccgca gcctgtccgg atgcccgcac aaagataggg tccctccaga aatccttgcc     1620

atgcatgaaa gtgtcctcaa gtgccccact ccgggctgca cggggcgcgg gcatgtcaac     1680

agcaacagga actcccaccg aagcctctcc ggatgcccga tcgctgcagc agagaaactg     1740

gccaaggcac aggaaaagca ccagagctgc gacgtgtcca agtccagcca ggcctcggac     1800

cgcgtgctca ggccaatgtg ctttgtgaag cagctggaga ttcctcagta tggctacaga     1860

aacaatgtcc ccacaactac gccgcgttcc aacctggcca aggagctcga gaaatattcc     1920

aagacctcgt ttgaatacaa cagttacgac aaccatactt atggcaagcg agccatagct     1980

cccaaggtgc aaaccaggga tatatccccc aaaggatatg atgatgcgaa gcggtactgc     2040

aaggacccca gccccagcag cagcagcacc agcagctacg cgcccagcag cagcagcaac     2100

ctgagctgcg gcgggggcag cagcgccagc agcacgtgca gcaagagcag cttcgactac     2160

acgcacgaca tggaggcggc ccacatggcg gccaccgcca tcctcaacct gtccacgcgc     2220

tgccgcgaga tgccgcagaa cctgagcacc aagccgcagg acctgtgcgc cacgcggaac     2280

cctgacatgg aggtggatga gaacgggacc ctggacctca gcatgaacaa gcagaggccg     2340

cgggacagct gctgccccat cctgacccct ctggagccca tgtcccccca gcagcaggca     2400

gtgatgaaca accggtgttt ccagctgggc gagggcgact gctgggactt gcccgtagac     2460

tacaccaaaa tgaaaccccg gaggatagac gaggacgagt ccaaagacat tactccagaa     2520

gacttggacc cattccagga ggctctagaa gaaagacggt atcccgggga ggtgaccatc     2580

ccaagtccca aacccaagta ccctcagtgc aaggagagca aaaaggactt aataactctg     2640

tctggctgcc ccctggcgga caaaagcatt cgaagtatgc tggccaccag ctcccaagaa     2700

ctcaagtgcc ccacgcctgg ctgtgatggt tctggacata tcaccggcaa ttatgcttct     2760

catcggagcc tttcaggttg cccaagagca aagaaaagtg gtatcaggat agcacagagc     2820

aaagaagata aagaagatca agaacccatc aggtgtccgg tccccgggtg cgacggccag     2880

ggccacatca ctgggaagta cgcgtcccat cgcagcgcct ccgggtgccc cttggcggcc     2940

aagaggcaga aagacgggta cctgaatggc tcccagttct cctggaagtc ggtcaagacg     3000

gaaggcatgt cctgccccac gccaggatgc gacggctcag gccacgtcag cggcagcttc     3060

ctcacacacc gcagcttgtc aggatgcccg agagccacgt cagcgatgaa gaaggcaaag     3120

ctttctggag agcagatgct gaccatcaaa cagcgggcca gcaacggtat agaaaatgat     3180

gaagaaatca aacagttaga tgaagaaatc aaggagctaa atgaatccaa ttcccagatg     3240

gaagccgata tgattaaact cagaactcag attaccacga tggagagcaa cctgaagacc     3300

atcgaagagg agaacaaagt gattgagcag cagaacgagt ctctcctcca cgagctggcg     3360

aacctgagcc agtctctgat ccacagcctg gctaacatcc agctgccgca catggatcca     3420

atcaatgaac aaaattttga tgcttacgtg actactttga cggaaatgta tacaaatcaa     3480

gatcgttatc agagtccaga aaataaagcc ctactggaaa atataaagca ggctgtgaga     3540

ggaattcagg tctga                                                      3555


<210>  44
<211>  1184
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Glu Val Asp Thr Glu Glu Lys Arg His Arg Thr Arg Ser Lys Gly 
1               5                   10                  15      


Val Arg Val Pro Val Glu Pro Ala Ile Gln Glu Leu Phe Ser Cys Pro 
            20                  25                  30          


Thr Pro Gly Cys Asp Gly Ser Gly His Val Ser Gly Lys Tyr Ala Arg 
        35                  40                  45              


His Arg Ser Val Tyr Gly Cys Pro Leu Ala Lys Lys Arg Lys Thr Gln 
    50                  55                  60                  


Asp Lys Gln Pro Gln Glu Pro Ala Pro Lys Arg Lys Pro Phe Ala Val 
65                  70                  75                  80  


Lys Ala Asp Ser Ser Ser Val Asp Glu Cys Asp Asp Ser Asp Gly Thr 
                85                  90                  95      


Glu Asp Met Asp Glu Lys Glu Glu Asp Glu Gly Glu Glu Tyr Ser Glu 
            100                 105                 110         


Asp Asn Asp Glu Pro Gly Asp Glu Asp Glu Glu Asp Glu Glu Gly Asp 
        115                 120                 125             


Arg Glu Glu Glu Glu Glu Ile Glu Glu Glu Asp Glu Asp Asp Asp Glu 
    130                 135                 140                 


Asp Gly Glu Asp Val Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu 
145                 150                 155                 160 


Glu Glu Glu Glu Glu Glu Glu Asn Glu Asp His Gln Met Asn Cys His 
                165                 170                 175     


Asn Thr Arg Ile Met Gln Asp Thr Glu Lys Asp Asp Asn Asn Asn Asp 
            180                 185                 190         


Glu Tyr Asp Asn Tyr Asp Glu Leu Val Ala Lys Ser Leu Leu Asn Leu 
        195                 200                 205             


Gly Lys Ile Ala Glu Asp Ala Ala Tyr Arg Ala Arg Thr Glu Ser Glu 
    210                 215                 220                 


Met Asn Ser Asn Thr Ser Asn Ser Leu Glu Asp Asp Ser Asp Lys Asn 
225                 230                 235                 240 


Glu Asn Leu Gly Arg Lys Ser Glu Leu Ser Leu Asp Leu Asp Ser Asp 
                245                 250                 255     


Val Val Arg Glu Thr Val Asp Ser Leu Lys Leu Leu Ala Gln Gly His 
            260                 265                 270         


Gly Val Val Leu Ser Glu Asn Met Asn Asp Arg Asn Tyr Ala Asp Ser 
        275                 280                 285             


Met Ser Gln Gln Asp Ser Arg Asn Met Asn Tyr Val Met Leu Gly Lys 
    290                 295                 300                 


Pro Met Asn Asn Gly Leu Met Glu Lys Met Val Glu Glu Ser Asp Glu 
305                 310                 315                 320 


Glu Val Cys Leu Ser Ser Leu Glu Cys Leu Arg Asn Gln Cys Phe Asp 
                325                 330                 335     


Leu Ala Arg Lys Leu Ser Glu Thr Asn Pro Gln Glu Arg Asn Pro Gln 
            340                 345                 350         


Gln Asn Met Asn Ile Arg Gln His Val Arg Pro Glu Glu Asp Phe Pro 
        355                 360                 365             


Gly Arg Thr Pro Asp Arg Asn Tyr Ser Asp Met Leu Asn Leu Met Arg 
    370                 375                 380                 


Leu Glu Glu Gln Leu Ser Pro Arg Ser Arg Val Phe Ala Ser Cys Ala 
385                 390                 395                 400 


Lys Glu Asp Gly Cys His Glu Arg Asp Asp Asp Thr Thr Ser Val Asn 
                405                 410                 415     


Ser Asp Arg Ser Glu Glu Val Phe Asp Met Thr Lys Gly Asn Leu Thr 
            420                 425                 430         


Leu Leu Glu Lys Ala Ile Ala Leu Glu Thr Glu Arg Ala Lys Ala Met 
        435                 440                 445             


Arg Glu Lys Met Ala Met Glu Ala Gly Arg Arg Asp Asn Met Arg Ser 
    450                 455                 460                 


Tyr Glu Asp Gln Ser Pro Arg Gln Leu Pro Gly Glu Asp Arg Lys Pro 
465                 470                 475                 480 


Lys Ser Ser Asp Ser His Val Lys Lys Pro Tyr Tyr Asp Pro Ser Arg 
                485                 490                 495     


Thr Glu Lys Lys Glu Ser Lys Cys Pro Thr Pro Gly Cys Asp Gly Thr 
            500                 505                 510         


Gly His Val Thr Gly Leu Tyr Pro His His Arg Ser Leu Ser Gly Cys 
        515                 520                 525             


Pro His Lys Asp Arg Val Pro Pro Glu Ile Leu Ala Met His Glu Ser 
    530                 535                 540                 


Val Leu Lys Cys Pro Thr Pro Gly Cys Thr Gly Arg Gly His Val Asn 
545                 550                 555                 560 


Ser Asn Arg Asn Ser His Arg Ser Leu Ser Gly Cys Pro Ile Ala Ala 
                565                 570                 575     


Ala Glu Lys Leu Ala Lys Ala Gln Glu Lys His Gln Ser Cys Asp Val 
            580                 585                 590         


Ser Lys Ser Ser Gln Ala Ser Asp Arg Val Leu Arg Pro Met Cys Phe 
        595                 600                 605             


Val Lys Gln Leu Glu Ile Pro Gln Tyr Gly Tyr Arg Asn Asn Val Pro 
    610                 615                 620                 


Thr Thr Thr Pro Arg Ser Asn Leu Ala Lys Glu Leu Glu Lys Tyr Ser 
625                 630                 635                 640 


Lys Thr Ser Phe Glu Tyr Asn Ser Tyr Asp Asn His Thr Tyr Gly Lys 
                645                 650                 655     


Arg Ala Ile Ala Pro Lys Val Gln Thr Arg Asp Ile Ser Pro Lys Gly 
            660                 665                 670         


Tyr Asp Asp Ala Lys Arg Tyr Cys Lys Asp Pro Ser Pro Ser Ser Ser 
        675                 680                 685             


Ser Thr Ser Ser Tyr Ala Pro Ser Ser Ser Ser Asn Leu Ser Cys Gly 
    690                 695                 700                 


Gly Gly Ser Ser Ala Ser Ser Thr Cys Ser Lys Ser Ser Phe Asp Tyr 
705                 710                 715                 720 


Thr His Asp Met Glu Ala Ala His Met Ala Ala Thr Ala Ile Leu Asn 
                725                 730                 735     


Leu Ser Thr Arg Cys Arg Glu Met Pro Gln Asn Leu Ser Thr Lys Pro 
            740                 745                 750         


Gln Asp Leu Cys Ala Thr Arg Asn Pro Asp Met Glu Val Asp Glu Asn 
        755                 760                 765             


Gly Thr Leu Asp Leu Ser Met Asn Lys Gln Arg Pro Arg Asp Ser Cys 
    770                 775                 780                 


Cys Pro Ile Leu Thr Pro Leu Glu Pro Met Ser Pro Gln Gln Gln Ala 
785                 790                 795                 800 


Val Met Asn Asn Arg Cys Phe Gln Leu Gly Glu Gly Asp Cys Trp Asp 
                805                 810                 815     


Leu Pro Val Asp Tyr Thr Lys Met Lys Pro Arg Arg Ile Asp Glu Asp 
            820                 825                 830         


Glu Ser Lys Asp Ile Thr Pro Glu Asp Leu Asp Pro Phe Gln Glu Ala 
        835                 840                 845             


Leu Glu Glu Arg Arg Tyr Pro Gly Glu Val Thr Ile Pro Ser Pro Lys 
    850                 855                 860                 


Pro Lys Tyr Pro Gln Cys Lys Glu Ser Lys Lys Asp Leu Ile Thr Leu 
865                 870                 875                 880 


Ser Gly Cys Pro Leu Ala Asp Lys Ser Ile Arg Ser Met Leu Ala Thr 
                885                 890                 895     


Ser Ser Gln Glu Leu Lys Cys Pro Thr Pro Gly Cys Asp Gly Ser Gly 
            900                 905                 910         


His Ile Thr Gly Asn Tyr Ala Ser His Arg Ser Leu Ser Gly Cys Pro 
        915                 920                 925             


Arg Ala Lys Lys Ser Gly Ile Arg Ile Ala Gln Ser Lys Glu Asp Lys 
    930                 935                 940                 


Glu Asp Gln Glu Pro Ile Arg Cys Pro Val Pro Gly Cys Asp Gly Gln 
945                 950                 955                 960 


Gly His Ile Thr Gly Lys Tyr Ala Ser His Arg Ser Ala Ser Gly Cys 
                965                 970                 975     


Pro Leu Ala Ala Lys Arg Gln Lys Asp Gly Tyr Leu Asn Gly Ser Gln 
            980                 985                 990         


Phe Ser Trp Lys Ser Val Lys Thr  Glu Gly Met Ser Cys  Pro Thr Pro 
        995                 1000                 1005             


Gly Cys  Asp Gly Ser Gly His  Val Ser Gly Ser Phe  Leu Thr His 
    1010                 1015                 1020             


Arg Ser  Leu Ser Gly Cys Pro  Arg Ala Thr Ser Ala  Met Lys Lys 
    1025                 1030                 1035             


Ala Lys  Leu Ser Gly Glu Gln  Met Leu Thr Ile Lys  Gln Arg Ala 
    1040                 1045                 1050             


Ser Asn  Gly Ile Glu Asn Asp  Glu Glu Ile Lys Gln  Leu Asp Glu 
    1055                 1060                 1065             


Glu Ile  Lys Glu Leu Asn Glu  Ser Asn Ser Gln Met  Glu Ala Asp 
    1070                 1075                 1080             


Met Ile  Lys Leu Arg Thr Gln  Ile Thr Thr Met Glu  Ser Asn Leu 
    1085                 1090                 1095             


Lys Thr  Ile Glu Glu Glu Asn  Lys Val Ile Glu Gln  Gln Asn Glu 
    1100                 1105                 1110             


Ser Leu  Leu His Glu Leu Ala  Asn Leu Ser Gln Ser  Leu Ile His 
    1115                 1120                 1125             


Ser Leu  Ala Asn Ile Gln Leu  Pro His Met Asp Pro  Ile Asn Glu 
    1130                 1135                 1140             


Gln Asn  Phe Asp Ala Tyr Val  Thr Thr Leu Thr Glu  Met Tyr Thr 
    1145                 1150                 1155             


Asn Gln  Asp Arg Tyr Gln Ser  Pro Glu Asn Lys Ala  Leu Leu Glu 
    1160                 1165                 1170             


Asn Ile  Lys Gln Ala Val Arg  Gly Ile Gln Val 
    1175                 1180                 


<210>  45
<211>  975
<212>  DNA
<213>  Mus musculus

<400>  45
atggaggaga aggattccaa gcccagcgag acggcggcgg aggcgcagag acagccggaa       60

cccagctccg gcggcggctc tggcggcggc agcagcccga gcgactcgga caccggccgc      120

cggcgggctc tgatgctgcc cgaggtccta caggcgccag gcaaccacca gcatccacat      180

cgcatcacca acttcttcat cgataacatc ctgcggcctg agtttggccg ccgaaaggac      240

gcggggactt gctgtgcggg cgcgggcgga gccaggggag gcgaaggcgg cgctggcact      300

accgaaggag gcggcggcgg cgcaggcgga gccgagcagc tactgggcgc cagggagtcc      360

cgaccgaacc cagcgtgcgc acccagcgcg ggaggaacgc tctccgccgc cgctggcgac      420

cctgcggtcg acggagaagg aggttccaag acgctatcac ttcacggtgg tgccaaaaaa      480

cccggcgatc ctgggggttc cttggatgga gtgctcaaag cccggggctt gggcggcggt      540

gacctgtcgg tgagctccga ctcggacagc tctcaagcca gcgccactct gggcgcgcag      600

cccatgctct ggcccgcttg ggtctactgc acgcgctatt ctgaccggcc ttcttcaggt      660

cccaggtccc gaaaaccaaa gaagaagaac cctaacaaag aggacaagcg gcctcgcaca      720

gccttcactg ctgagcagct ccagaggctc aaggctgagt ttcagaccaa caggtacctg      780

acagagcagc ggcgccagag tctggcacag gagctcagcc tgaacgagtc tcagatcaag      840

atttggttcc agaacaagcg ggccaaaatc aagaaagcca cgggcaacaa gaacactttg      900

gcggtgcacc tcatggcaca gggcctgtac aaccattcca ccacggccaa ggagggcaag      960

tcggacagcg agtag                                                       975


<210>  46
<211>  324
<212>  PRT
<213>  Mus musculus

<400>  46

Met Glu Glu Lys Asp Ser Lys Pro Ser Glu Thr Ala Ala Glu Ala Gln 
1               5                   10                  15      


Arg Gln Pro Glu Pro Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Ser 
            20                  25                  30          


Pro Ser Asp Ser Asp Thr Gly Arg Arg Arg Ala Leu Met Leu Pro Glu 
        35                  40                  45              


Val Leu Gln Ala Pro Gly Asn His Gln His Pro His Arg Ile Thr Asn 
    50                  55                  60                  


Phe Phe Ile Asp Asn Ile Leu Arg Pro Glu Phe Gly Arg Arg Lys Asp 
65                  70                  75                  80  


Ala Gly Thr Cys Cys Ala Gly Ala Gly Gly Ala Arg Gly Gly Glu Gly 
                85                  90                  95      


Gly Ala Gly Thr Thr Glu Gly Gly Gly Gly Gly Ala Gly Gly Ala Glu 
            100                 105                 110         


Gln Leu Leu Gly Ala Arg Glu Ser Arg Pro Asn Pro Ala Cys Ala Pro 
        115                 120                 125             


Ser Ala Gly Gly Thr Leu Ser Ala Ala Ala Gly Asp Pro Ala Val Asp 
    130                 135                 140                 


Gly Glu Gly Gly Ser Lys Thr Leu Ser Leu His Gly Gly Ala Lys Lys 
145                 150                 155                 160 


Pro Gly Asp Pro Gly Gly Ser Leu Asp Gly Val Leu Lys Ala Arg Gly 
                165                 170                 175     


Leu Gly Gly Gly Asp Leu Ser Val Ser Ser Asp Ser Asp Ser Ser Gln 
            180                 185                 190         


Ala Ser Ala Thr Leu Gly Ala Gln Pro Met Leu Trp Pro Ala Trp Val 
        195                 200                 205             


Tyr Cys Thr Arg Tyr Ser Asp Arg Pro Ser Ser Gly Pro Arg Ser Arg 
    210                 215                 220                 


Lys Pro Lys Lys Lys Asn Pro Asn Lys Glu Asp Lys Arg Pro Arg Thr 
225                 230                 235                 240 


Ala Phe Thr Ala Glu Gln Leu Gln Arg Leu Lys Ala Glu Phe Gln Thr 
                245                 250                 255     


Asn Arg Tyr Leu Thr Glu Gln Arg Arg Gln Ser Leu Ala Gln Glu Leu 
            260                 265                 270         


Ser Leu Asn Glu Ser Gln Ile Lys Ile Trp Phe Gln Asn Lys Arg Ala 
        275                 280                 285             


Lys Ile Lys Lys Ala Thr Gly Asn Lys Asn Thr Leu Ala Val His Leu 
    290                 295                 300                 


Met Ala Gln Gly Leu Tyr Asn His Ser Thr Thr Ala Lys Glu Gly Lys 
305                 310                 315                 320 


Ser Asp Ser Glu 
                


<210>  47
<211>  1002
<212>  DNA
<213>  Homo sapiens

<400>  47
atggaggaga atgaccccaa gcctggcgaa gcagcggcgg cggtggaggg acagcggcag       60

ccggaatcca gccccggcgg cggctcgggc ggcggcggcg gtagcagccc gggcgaagcg      120

gacaccgggc gccggcgggc tctgatgctg cccgcggtcc tgcaggcgcc cggcaaccac      180

cagcacccgc accgcatcac caacttcttc atcgacaaca tcctgcggcc cgagttcggc      240

cggcgaaagg acgcggggac ctgctgtgcg ggcgcgggag gaggaagggg cggcggagcc      300

ggcggcgaag gcggcgcgag cggtgcggag ggaggcggcg gcgcgggcgg ctcggagcag      360

ctcttgggct cgggctcccg agagccccgg cagaacccgc catgtgcgcc cggcgcgggc      420

gggccgctcc cagccgccgg cagcgactct ccgggtgacg gggaaggcgg ctccaagacg      480

ctctcgctgc acggtggcgc caagaaaggc ggcgaccccg gcggccccct ggacgggtcg      540

ctcaaggccc gcggcttggg cggcggcgac ctgtcggtga gctcggactc ggacagctcg      600

caagccggcg ccaacctggg cgcgcagccc atgctctggc cggcgtgggt ctactgtacg      660

cgctactcgg accggccttc ttcaggtccc aggtctcgaa aaccaaagaa gaagaacccg      720

aacaaagagg acaagcggcc gcgcacggcc tttaccgccg agcagctgca gaggctcaag      780

gccgagttcc agaccaacag gtacctgacg gagcagcggc gccagagcct ggcgcaggag      840

ctgagcctca acgagtcaca gatcaagatt tggttccaga acaagcgcgc caagatcaag      900

aaggccacgg gcaacaagaa cacgctggcc gtgcacctca tggcacaggg cttgtacaac      960

cactccacca cagccaagga gggcaagtcg gacagcgagt ag                        1002


<210>  48
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Glu Glu Asn Asp Pro Lys Pro Gly Glu Ala Ala Ala Ala Val Glu 
1               5                   10                  15      


Gly Gln Arg Gln Pro Glu Ser Ser Pro Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Gly Ser Ser Pro Gly Glu Ala Asp Thr Gly Arg Arg Arg Ala Leu 
        35                  40                  45              


Met Leu Pro Ala Val Leu Gln Ala Pro Gly Asn His Gln His Pro His 
    50                  55                  60                  


Arg Ile Thr Asn Phe Phe Ile Asp Asn Ile Leu Arg Pro Glu Phe Gly 
65                  70                  75                  80  


Arg Arg Lys Asp Ala Gly Thr Cys Cys Ala Gly Ala Gly Gly Gly Arg 
                85                  90                  95      


Gly Gly Gly Ala Gly Gly Glu Gly Gly Ala Ser Gly Ala Glu Gly Gly 
            100                 105                 110         


Gly Gly Ala Gly Gly Ser Glu Gln Leu Leu Gly Ser Gly Ser Arg Glu 
        115                 120                 125             


Pro Arg Gln Asn Pro Pro Cys Ala Pro Gly Ala Gly Gly Pro Leu Pro 
    130                 135                 140                 


Ala Ala Gly Ser Asp Ser Pro Gly Asp Gly Glu Gly Gly Ser Lys Thr 
145                 150                 155                 160 


Leu Ser Leu His Gly Gly Ala Lys Lys Gly Gly Asp Pro Gly Gly Pro 
                165                 170                 175     


Leu Asp Gly Ser Leu Lys Ala Arg Gly Leu Gly Gly Gly Asp Leu Ser 
            180                 185                 190         


Val Ser Ser Asp Ser Asp Ser Ser Gln Ala Gly Ala Asn Leu Gly Ala 
        195                 200                 205             


Gln Pro Met Leu Trp Pro Ala Trp Val Tyr Cys Thr Arg Tyr Ser Asp 
    210                 215                 220                 


Arg Pro Ser Ser Gly Pro Arg Ser Arg Lys Pro Lys Lys Lys Asn Pro 
225                 230                 235                 240 


Asn Lys Glu Asp Lys Arg Pro Arg Thr Ala Phe Thr Ala Glu Gln Leu 
                245                 250                 255     


Gln Arg Leu Lys Ala Glu Phe Gln Thr Asn Arg Tyr Leu Thr Glu Gln 
            260                 265                 270         


Arg Arg Gln Ser Leu Ala Gln Glu Leu Ser Leu Asn Glu Ser Gln Ile 
        275                 280                 285             


Lys Ile Trp Phe Gln Asn Lys Arg Ala Lys Ile Lys Lys Ala Thr Gly 
    290                 295                 300                 


Asn Lys Asn Thr Leu Ala Val His Leu Met Ala Gln Gly Leu Tyr Asn 
305                 310                 315                 320 


His Ser Thr Thr Ala Lys Glu Gly Lys Ser Asp Ser Glu 
                325                 330             


<210>  49
<211>  1407
<212>  DNA
<213>  Mus musculus

<400>  49
atgttaggga ctgtgaagat ggaagggcat gagagcaacg actggaacag ctactacgcg       60

gacacgcagg aggcctactc ctctgtccct gtcagcaaca tgaactccgg cctgggctct      120

atgaactcca tgaacaccta catgaccatg aacaccatga ccacgagcgg caacatgacc      180

ccggcttcct tcaacatgtc ctacgccaac acgggcttag gggccggcct gagtcccggt      240

gctgtggctg gcatgccagg ggcctctgca ggcgccatga acagcatgac tgcggcgggc      300

gtcacggcca tgggtacggc gctgagcccg ggaggcatgg gctccatggg cgcgcagccc      360

gccacctcca tgaacggcct gggtccctac gccgccgcca tgaacccgtg catgagtccc      420

atggcgtacg cgccgtccaa cctgggccgc agccgcgcgg ggggcggcgg cgacgccaag      480

acattcaagc gcagctaccc tcacgccaag ccgccttact cctacatctc gctcatcacg      540

atggccatcc agcaggcgcc cagcaagatg ctcacgctga gcgagatcta ccagtggatc      600

atggacctct tcccctatta ccgccagaac cagcagcgct ggcagaactc catccgccac      660

tcgctgtcct tcaacgattg tttcgtcaag gtggcacgat ccccggacaa gccaggcaag      720

ggctcctact ggacgctgca cccggactcc ggcaacatgt tcgagaacgg ctgctacttg      780

cgccgccaaa agcgcttcaa gtgtgagaag cagccggggg ccggaggtgg gagtgggggc      840

ggcggctcca aagggggccc agaaagtcgc aaggacccct caggcccggg gaaccccagc      900

gccgagtcac cccttcaccg gggtgtgcac ggaaaggcta gccagctaga gggcgcgccg      960

gccccagggc ccgccgccag cccccagact ctggaccaca gcggggccac ggcgacaggg     1020

ggcgcttcgg agttgaagtc tccagcgtct tcatctgcgc cccccataag ctccgggcca     1080

ggggcgctag catctgtacc cccctctcac ccggctcacg gcctggcacc ccacgaatct     1140

cagctgcatc tgaaagggga tccccactac tcctttaatc accccttctc catcaacaac     1200

ctcatgtcct cctccgagca acagcacaag ctggacttca aggcatacga gcaggcgctg     1260

cagtactctc cttatggcgc taccttgccc gccagtctgc cccttggcag cgcctcagtg     1320

gccacgagga gccccatcga gccctcagcc ctggagccag cctactacca aggtgtgtat     1380

tccagacccg tgctaaatac ttcctag                                         1407


<210>  50
<211>  468
<212>  PRT
<213>  Mus musculus

<400>  50

Met Leu Gly Thr Val Lys Met Glu Gly His Glu Ser Asn Asp Trp Asn 
1               5                   10                  15      


Ser Tyr Tyr Ala Asp Thr Gln Glu Ala Tyr Ser Ser Val Pro Val Ser 
            20                  25                  30          


Asn Met Asn Ser Gly Leu Gly Ser Met Asn Ser Met Asn Thr Tyr Met 
        35                  40                  45              


Thr Met Asn Thr Met Thr Thr Ser Gly Asn Met Thr Pro Ala Ser Phe 
    50                  55                  60                  


Asn Met Ser Tyr Ala Asn Thr Gly Leu Gly Ala Gly Leu Ser Pro Gly 
65                  70                  75                  80  


Ala Val Ala Gly Met Pro Gly Ala Ser Ala Gly Ala Met Asn Ser Met 
                85                  90                  95      


Thr Ala Ala Gly Val Thr Ala Met Gly Thr Ala Leu Ser Pro Gly Gly 
            100                 105                 110         


Met Gly Ser Met Gly Ala Gln Pro Ala Thr Ser Met Asn Gly Leu Gly 
        115                 120                 125             


Pro Tyr Ala Ala Ala Met Asn Pro Cys Met Ser Pro Met Ala Tyr Ala 
    130                 135                 140                 


Pro Ser Asn Leu Gly Arg Ser Arg Ala Gly Gly Gly Gly Asp Ala Lys 
145                 150                 155                 160 


Thr Phe Lys Arg Ser Tyr Pro His Ala Lys Pro Pro Tyr Ser Tyr Ile 
                165                 170                 175     


Ser Leu Ile Thr Met Ala Ile Gln Gln Ala Pro Ser Lys Met Leu Thr 
            180                 185                 190         


Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu Phe Pro Tyr Tyr Arg 
        195                 200                 205             


Gln Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg His Ser Leu Ser Phe 
    210                 215                 220                 


Asn Asp Cys Phe Val Lys Val Ala Arg Ser Pro Asp Lys Pro Gly Lys 
225                 230                 235                 240 


Gly Ser Tyr Trp Thr Leu His Pro Asp Ser Gly Asn Met Phe Glu Asn 
                245                 250                 255     


Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys Cys Glu Lys Gln Pro 
            260                 265                 270         


Gly Ala Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Gly Gly Pro Glu 
        275                 280                 285             


Ser Arg Lys Asp Pro Ser Gly Pro Gly Asn Pro Ser Ala Glu Ser Pro 
    290                 295                 300                 


Leu His Arg Gly Val His Gly Lys Ala Ser Gln Leu Glu Gly Ala Pro 
305                 310                 315                 320 


Ala Pro Gly Pro Ala Ala Ser Pro Gln Thr Leu Asp His Ser Gly Ala 
                325                 330                 335     


Thr Ala Thr Gly Gly Ala Ser Glu Leu Lys Ser Pro Ala Ser Ser Ser 
            340                 345                 350         


Ala Pro Pro Ile Ser Ser Gly Pro Gly Ala Leu Ala Ser Val Pro Pro 
        355                 360                 365             


Ser His Pro Ala His Gly Leu Ala Pro His Glu Ser Gln Leu His Leu 
    370                 375                 380                 


Lys Gly Asp Pro His Tyr Ser Phe Asn His Pro Phe Ser Ile Asn Asn 
385                 390                 395                 400 


Leu Met Ser Ser Ser Glu Gln Gln His Lys Leu Asp Phe Lys Ala Tyr 
                405                 410                 415     


Glu Gln Ala Leu Gln Tyr Ser Pro Tyr Gly Ala Thr Leu Pro Ala Ser 
            420                 425                 430         


Leu Pro Leu Gly Ser Ala Ser Val Ala Thr Arg Ser Pro Ile Glu Pro 
        435                 440                 445             


Ser Ala Leu Glu Pro Ala Tyr Tyr Gln Gly Val Tyr Ser Arg Pro Val 
    450                 455                 460                 


Leu Asn Thr Ser 
465             


<210>  51
<211>  1419
<212>  DNA
<213>  Homo sapiens

<400>  51
atgttaggaa ctgtgaagat ggaagggcat gaaaccagcg actggaacag ctactacgca       60

gacacgcagg aggcctactc ctccgtcccg gtcagcaaca tgaactcagg cctgggctcc      120

atgaactcca tgaacaccta catgaccatg aacaccatga ctacgagcgg caacatgacc      180

ccggcgtcct tcaacatgtc ctatgccaac ccgggcctag gggccggcct gagtcccggc      240

gcagtagccg gcatgccggg gggctcggcg ggcgccatga acagcatgac tgcggccggc      300

gtgacggcca tgggtacggc gctgagcccg agcggcatgg gcgccatggg tgcgcagcag      360

gcggcctcca tgaatggcct gggcccctac gcggccgcca tgaacccgtg catgagcccc      420

atggcgtacg cgccgtccaa cctgggccgc agccgcgcgg gcggcggcgg cgacgccaag      480

acgttcaagc gcagctaccc gcacgccaag ccgccctact cgtacatctc gctcatcacc      540

atggccatcc agcaggcgcc cagcaagatg ctcacgctga gcgagatcta ccagtggatc      600

atggacctct tcccctatta ccggcagaac cagcagcgct ggcagaactc catccgccac      660

tcgctgtcct tcaatgactg cttcgtcaag gtggcacgct ccccggacaa gccgggcaag      720

ggctcctact ggacgctgca cccggactcc ggcaacatgt tcgagaacgg ctgctacttg      780

cgccgccaga agcgcttcaa gtgcgagaag cagccggggg ccggcggcgg gggcgggagc      840

ggaagcgggg gcagcggcgc caagggcggc cctgagagcc gcaaggaccc ctctggcgcc      900

tctaacccca gcgccgactc gcccctccat cggggtgtgc acgggaagac cggccagcta      960

gagggcgcgc cggcccccgg gcccgccgcc agcccccaga ctctggacca cagtggggcg     1020

acggcgacag ggggcgcctc ggagttgaag actccagcct cctcaactgc gccccccata     1080

agctccgggc ccggggcgct ggcctctgtg cccgcctctc acccggcaca cggcttggca     1140

ccccacgagt cccagctgca cctgaaaggg gacccccact actccttcaa ccacccgttc     1200

tccatcaaca acctcatgtc ctcctcggag cagcagcata agctggactt caaggcatac     1260

gaacaggcac tgcaatactc gccttacggc tctacgttgc ccgccagcct gcctctaggc     1320

agcgcctcgg tgaccaccag gagccccatc gagccctcag ccctggagcc ggcgtactac     1380

caaggtgtgt attccagacc cgtcctaaac acttcctag                            1419


<210>  52
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Leu Gly Thr Val Lys Met Glu Gly His Glu Thr Ser Asp Trp Asn 
1               5                   10                  15      


Ser Tyr Tyr Ala Asp Thr Gln Glu Ala Tyr Ser Ser Val Pro Val Ser 
            20                  25                  30          


Asn Met Asn Ser Gly Leu Gly Ser Met Asn Ser Met Asn Thr Tyr Met 
        35                  40                  45              


Thr Met Asn Thr Met Thr Thr Ser Gly Asn Met Thr Pro Ala Ser Phe 
    50                  55                  60                  


Asn Met Ser Tyr Ala Asn Pro Gly Leu Gly Ala Gly Leu Ser Pro Gly 
65                  70                  75                  80  


Ala Val Ala Gly Met Pro Gly Gly Ser Ala Gly Ala Met Asn Ser Met 
                85                  90                  95      


Thr Ala Ala Gly Val Thr Ala Met Gly Thr Ala Leu Ser Pro Ser Gly 
            100                 105                 110         


Met Gly Ala Met Gly Ala Gln Gln Ala Ala Ser Met Asn Gly Leu Gly 
        115                 120                 125             


Pro Tyr Ala Ala Ala Met Asn Pro Cys Met Ser Pro Met Ala Tyr Ala 
    130                 135                 140                 


Pro Ser Asn Leu Gly Arg Ser Arg Ala Gly Gly Gly Gly Asp Ala Lys 
145                 150                 155                 160 


Thr Phe Lys Arg Ser Tyr Pro His Ala Lys Pro Pro Tyr Ser Tyr Ile 
                165                 170                 175     


Ser Leu Ile Thr Met Ala Ile Gln Gln Ala Pro Ser Lys Met Leu Thr 
            180                 185                 190         


Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu Phe Pro Tyr Tyr Arg 
        195                 200                 205             


Gln Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg His Ser Leu Ser Phe 
    210                 215                 220                 


Asn Asp Cys Phe Val Lys Val Ala Arg Ser Pro Asp Lys Pro Gly Lys 
225                 230                 235                 240 


Gly Ser Tyr Trp Thr Leu His Pro Asp Ser Gly Asn Met Phe Glu Asn 
                245                 250                 255     


Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys Cys Glu Lys Gln Pro 
            260                 265                 270         


Gly Ala Gly Gly Gly Gly Gly Ser Gly Ser Gly Gly Ser Gly Ala Lys 
        275                 280                 285             


Gly Gly Pro Glu Ser Arg Lys Asp Pro Ser Gly Ala Ser Asn Pro Ser 
    290                 295                 300                 


Ala Asp Ser Pro Leu His Arg Gly Val His Gly Lys Thr Gly Gln Leu 
305                 310                 315                 320 


Glu Gly Ala Pro Ala Pro Gly Pro Ala Ala Ser Pro Gln Thr Leu Asp 
                325                 330                 335     


His Ser Gly Ala Thr Ala Thr Gly Gly Ala Ser Glu Leu Lys Thr Pro 
            340                 345                 350         


Ala Ser Ser Thr Ala Pro Pro Ile Ser Ser Gly Pro Gly Ala Leu Ala 
        355                 360                 365             


Ser Val Pro Ala Ser His Pro Ala His Gly Leu Ala Pro His Glu Ser 
    370                 375                 380                 


Gln Leu His Leu Lys Gly Asp Pro His Tyr Ser Phe Asn His Pro Phe 
385                 390                 395                 400 


Ser Ile Asn Asn Leu Met Ser Ser Ser Glu Gln Gln His Lys Leu Asp 
                405                 410                 415     


Phe Lys Ala Tyr Glu Gln Ala Leu Gln Tyr Ser Pro Tyr Gly Ser Thr 
            420                 425                 430         


Leu Pro Ala Ser Leu Pro Leu Gly Ser Ala Ser Val Thr Thr Arg Ser 
        435                 440                 445             


Pro Ile Glu Pro Ser Ala Leu Glu Pro Ala Tyr Tyr Gln Gly Val Tyr 
    450                 455                 460                 


Ser Arg Pro Val Leu Asn Thr Ser 
465                 470         


<210>  53
<211>  912
<212>  DNA
<213>  Mus musculus

<400>  53
atggccccgg ctgctgctat gacttctttg ccactcggtg tcaaagtgga ggactccgcc       60

ttcgccaagc ctgctggggg aggcgttggc caagcccccg gggctgctgc ggccaccgca      120

accgccatgg gcacagatga ggagggggcc aagcccaaag tgcccgcttc actcctgccc      180

ttcagcgtgg aggccctcat ggccgatcac aggaagcccg gggccaagga gagcgtcctg      240

gtggcctccg aaggggctca ggcagcgggt ggctcggtgc agcacttggg cacccggccc      300

gggtctctgg gcgccccgga tgcgccctcc tcgccgcggc ctctcggcca tttctcagtc      360

ggaggactcc tcaagctgcc agaagatgct ctggtgaagg ccgaaagccc cgagaaacta      420

gatcggaccc cgtggatgca gagtccccgc ttctccccgc ccccagccag acggctgagt      480

cccccagcat gcaccctacg caagcacaag accaaccgca agcccaggac gcctttcacc      540

acagctcagc tgctggctct ggagcgcaag ttccgccaga agcagtacct gtctattgcc      600

gagcgcgcgg aattctccag ctcgctcagc ctcaccgaga cccaggtgaa gatctggttc      660

cagaaccgtc gcgctaaggc caagagactg caggaggcgg agctggagaa gctgaagatg      720

gccgcgaaac ccatgttgcc gcctgctgcc ttcggcctct cttttcctct tggcggtcct      780

gcagcggtgg ctgcagctgc gggcgcctca ctctacagtg cctctggccc tttccagcgc      840

gccgcgctgc ctgtagcgcc cgtgggactc tacaccgccc atgtaggcta cagcatgtac      900

cacctgactt ag                                                          912


<210>  54
<211>  303
<212>  PRT
<213>  Mus musculus

<400>  54

Met Ala Pro Ala Ala Ala Met Thr Ser Leu Pro Leu Gly Val Lys Val 
1               5                   10                  15      


Glu Asp Ser Ala Phe Ala Lys Pro Ala Gly Gly Gly Val Gly Gln Ala 
            20                  25                  30          


Pro Gly Ala Ala Ala Ala Thr Ala Thr Ala Met Gly Thr Asp Glu Glu 
        35                  40                  45              


Gly Ala Lys Pro Lys Val Pro Ala Ser Leu Leu Pro Phe Ser Val Glu 
    50                  55                  60                  


Ala Leu Met Ala Asp His Arg Lys Pro Gly Ala Lys Glu Ser Val Leu 
65                  70                  75                  80  


Val Ala Ser Glu Gly Ala Gln Ala Ala Gly Gly Ser Val Gln His Leu 
                85                  90                  95      


Gly Thr Arg Pro Gly Ser Leu Gly Ala Pro Asp Ala Pro Ser Ser Pro 
            100                 105                 110         


Arg Pro Leu Gly His Phe Ser Val Gly Gly Leu Leu Lys Leu Pro Glu 
        115                 120                 125             


Asp Ala Leu Val Lys Ala Glu Ser Pro Glu Lys Leu Asp Arg Thr Pro 
    130                 135                 140                 


Trp Met Gln Ser Pro Arg Phe Ser Pro Pro Pro Ala Arg Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Ala Cys Thr Leu Arg Lys His Lys Thr Asn Arg Lys Pro Arg 
                165                 170                 175     


Thr Pro Phe Thr Thr Ala Gln Leu Leu Ala Leu Glu Arg Lys Phe Arg 
            180                 185                 190         


Gln Lys Gln Tyr Leu Ser Ile Ala Glu Arg Ala Glu Phe Ser Ser Ser 
        195                 200                 205             


Leu Ser Leu Thr Glu Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg 
    210                 215                 220                 


Ala Lys Ala Lys Arg Leu Gln Glu Ala Glu Leu Glu Lys Leu Lys Met 
225                 230                 235                 240 


Ala Ala Lys Pro Met Leu Pro Pro Ala Ala Phe Gly Leu Ser Phe Pro 
                245                 250                 255     


Leu Gly Gly Pro Ala Ala Val Ala Ala Ala Ala Gly Ala Ser Leu Tyr 
            260                 265                 270         


Ser Ala Ser Gly Pro Phe Gln Arg Ala Ala Leu Pro Val Ala Pro Val 
        275                 280                 285             


Gly Leu Tyr Thr Ala His Val Gly Tyr Ser Met Tyr His Leu Thr 
    290                 295                 300             


<210>  55
<211>  912
<212>  DNA
<213>  Homo sapiens

<400>  55
atggccccgg ctgctgacat gacttctttg ccactcggtg tcaaagtgga ggactccgcc       60

ttcggcaagc cggcgggggg aggcgcgggc caggccccca gcgccgccgc ggccacggca      120

gccgccatgg gcgcggacga ggagggggcc aagcccaaag tgtccccttc gctcctgccc      180

ttcagcgtgg aggcgctcat ggccgaccac aggaagccgg gggccaagga gagcgccctg      240

gcgccctccg agggcgtgca ggcggcgggt ggctcggcgc agccactggg cgtcccgccg      300

gggtcgctgg gagccccgga cgcgccctct tcgccgcggc cgctcggcca tttctcggtg      360

gggggactcc tcaagctgcc agaagatgcg ctcgtcaaag ccgagagccc cgagaagccc      420

gagaggaccc cgtggatgca gagcccccgc ttctccccgc cgccggccag gcggctgagc      480

cccccagcct gcaccctccg caaacacaag acgaaccgta agccgcggac gcccttcacc      540

accgcgcagc tgctggcgct ggagcgcaag ttccgccaga agcagtacct gtccatcgcc      600

gagcgcgcgg agttctccag ctcgctcagc ctcactgaga cgcaggtgaa gatatggttc      660

cagaaccgcc gcgccaaggc aaagagacta caagaggcag agctggagaa gctgaagatg      720

gccgccaagc ccatgctgcc accggctgcc ttcggcctct ccttccctct cggcggcccc      780

gcagctgtag cggccgcggc gggtgcctcg ctctacggtg cctctggccc cttccagcgc      840

gccgcgctgc ctgtggcgcc cgtgggactc tacacggccc atgtgggcta cagcatgtac      900

cacctgacat ag                                                          912


<210>  56
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Pro Ala Ala Asp Met Thr Ser Leu Pro Leu Gly Val Lys Val 
1               5                   10                  15      


Glu Asp Ser Ala Phe Gly Lys Pro Ala Gly Gly Gly Ala Gly Gln Ala 
            20                  25                  30          


Pro Ser Ala Ala Ala Ala Thr Ala Ala Ala Met Gly Ala Asp Glu Glu 
        35                  40                  45              


Gly Ala Lys Pro Lys Val Ser Pro Ser Leu Leu Pro Phe Ser Val Glu 
    50                  55                  60                  


Ala Leu Met Ala Asp His Arg Lys Pro Gly Ala Lys Glu Ser Ala Leu 
65                  70                  75                  80  


Ala Pro Ser Glu Gly Val Gln Ala Ala Gly Gly Ser Ala Gln Pro Leu 
                85                  90                  95      


Gly Val Pro Pro Gly Ser Leu Gly Ala Pro Asp Ala Pro Ser Ser Pro 
            100                 105                 110         


Arg Pro Leu Gly His Phe Ser Val Gly Gly Leu Leu Lys Leu Pro Glu 
        115                 120                 125             


Asp Ala Leu Val Lys Ala Glu Ser Pro Glu Lys Pro Glu Arg Thr Pro 
    130                 135                 140                 


Trp Met Gln Ser Pro Arg Phe Ser Pro Pro Pro Ala Arg Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Ala Cys Thr Leu Arg Lys His Lys Thr Asn Arg Lys Pro Arg 
                165                 170                 175     


Thr Pro Phe Thr Thr Ala Gln Leu Leu Ala Leu Glu Arg Lys Phe Arg 
            180                 185                 190         


Gln Lys Gln Tyr Leu Ser Ile Ala Glu Arg Ala Glu Phe Ser Ser Ser 
        195                 200                 205             


Leu Ser Leu Thr Glu Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg 
    210                 215                 220                 


Ala Lys Ala Lys Arg Leu Gln Glu Ala Glu Leu Glu Lys Leu Lys Met 
225                 230                 235                 240 


Ala Ala Lys Pro Met Leu Pro Pro Ala Ala Phe Gly Leu Ser Phe Pro 
                245                 250                 255     


Leu Gly Gly Pro Ala Ala Val Ala Ala Ala Ala Gly Ala Ser Leu Tyr 
            260                 265                 270         


Gly Ala Ser Gly Pro Phe Gln Arg Ala Ala Leu Pro Val Ala Pro Val 
        275                 280                 285             


Gly Leu Tyr Thr Ala His Val Gly Tyr Ser Met Tyr His Leu Thr 
    290                 295                 300             


<210>  57
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  57
aaacagactt tgaattttga ccttctcaag ttggcgggag acgtggagtc caacccaggg       60

ccc                                                                     63


<210>  58
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  58
gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccct             54


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  59
acgaccctct tagcccagag                                                   20


<210>  60
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  60
ggccgaaggg acgtagcag                                                    19


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  61
ctgcaagtga ggaggtcatc                                                   20


<210>  62
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  62
ctgctggctt gacaaccac                                                    19


<210>  63
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  63
tttggaagat agggcctgca ctg                                               23


<210>  64
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  64
cctggatgcg gctatacaac actg                                              24


<210>  65
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  65
agcagaacgg agtgcagct                                                    19


<210>  66
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  66
gtatgctctg atgccgtct                                                    19


<210>  67
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  67
cgtgggacca atgtcttctg tg                                                22


<210>  68
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  68
atggtgaagg aggagaagaa gt                                                22


<210>  69
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  69
acgcaagtga attccgaagg agag                                              24


<210>  70
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  70
cagccgatgg atcactttgg t                                                 21


<210>  71
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  71
cctactggct gctcggacta a                                                 21


<210>  72
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  72
gcgtaccagt gactcaaact c                                                 21


<210>  73
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  73
gcccttcatc gtcaccctgc t                                                 21


<210>  74
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  74
tgggcatggt ctggatctca a                                                 21


<210>  75
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  75
tcaagactga ctcacagcaa cccc                                              24


<210>  76
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  76
ctttgtcctg aaccgtggtg gtag                                              24


<210>  77
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  77
caagatcatc agcaatgcct cctg                                              24


<210>  78
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  78
gcctgcttca ccaccttctt ga                                                22


<210>  79
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  79
ggcattgctc tcaatgacaa                                                   20


<210>  80
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  80
agggcctctc tcttgctctc                                                   20


<210>  81
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  81
cctcagcgtg cgtgtggtc                                                    19


<210>  82
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  82
agcagtcgct gaggctggtg                                                   20


<210>  83
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  83
ctcaccccac cccagatgcc t                                                 21


<210>  84
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  84
ctccctcccc agcccacctc t                                                 21


<210>  85
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  85
ccccattgac catctgtact                                                   20


<210>  86
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  86
ggccgaaggg acgtagcag                                                    19


<210>  87
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  87
ggacattccc ggacacacac                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  88
tctcgatctt cgtgagcttg                                                   20


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  89
ttgctgccct ggctatggtc a                                                 21


<210>  90
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  90
acaagcaagc atggccaaac a                                                 21


<210>  91
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  91
tctacctgaa attggaagac                                                   20


<210>  92
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  92
ggccgaaggg acgtagcag                                                    19


<210>  93
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  93
cgccttacgc agtcaatggg                                                   20


<210>  94
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  94
gacagtgggg agatggacgc t                                                 21


<210>  95
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  95
gcaactggcc gcccaagg                                                     18


<210>  96
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  96
aggccccacg ttgaccga                                                     18


<210>  97
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  97
ggcggcaacc agaagaacag                                                   20


<210>  98
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  98
gcttggcctg cgtcgatgaa c                                                 21


<210>  99
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  99
gagtacaccg ccgaggagat tg                                                22


<210>  100
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  100
gcggatatac tgggtgcact gg                                                22


<210>  101
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  101
tgtcacgtcc ccaaggttca t                                                 21


<210>  102
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  102
gggcaggccg ggtctctaag t                                                 21


<210>  103
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  103
gattcagagg caggtgcctg                                                   20


<210>  104
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  104
gcatagtgca agctggtggt c                                                 21


<210>  105
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  105
ttggtctgtt gtttgcctcg aaag                                              24


<210>  106
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  106
gggtccttca gcagcgtggt tag                                               23


<210>  107
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  107
atccagactg ccaggccagc g                                                 21


<210>  108
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  108
ctccatccaa gagcaccaag g                                                 21


<210>  109
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  109
tgggctcctg tggctgtgtt ctag                                              24


<210>  110
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  110
ccggagcaca aggagtttca gt                                                22


