                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       June, Carl H
       Porter, David L
       Kalos, Michael
       Levine, Bruce L
 
<120>  USE OF CHIMERIC ANTIGEN RECEPTOR-MODIFIED T CELLS TO TREAT CANCER

<130>  46483-6001-00-WO.601218

<150>  61/421,470
<151>  2010-12-09

<150>  61/502,649
<151>  2010-06-29

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  9174
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  1
gcgcgctcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg cgttacccaa       60

cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga agaggcccgc      120

accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatgggacgc gccctgtagc      180

ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc      240

gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt      300

ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac      360

ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc gccctgatag      420

acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa      480

actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg gattttgccg      540

atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattttaac      600

aaaatattaa cgcttacaat ttaggtggca cttttcgggg aaatgtgcgc ggaaccccta      660

tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat      720

aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc      780

ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga      840

aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca      900

acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt      960

ttaaagttct gctatgtggc gcggtattat cccgtattga cgccgggcaa gagcaactcg     1020

gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc     1080

atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata     1140

acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt     1200

tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag     1260

ccataccaaa cgacgagcgt gacaccacga tgcctgtagc aatggcaaca acgttgcgca     1320

aactattaac tggcgaacta cttactctag cttcccggca acaattaata gactggatgg     1380

aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg     1440

ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag     1500

atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg     1560

aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag     1620

accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga     1680

tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt     1740

tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc     1800

tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc     1860

cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac     1920

caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac     1980

cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt     2040

cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct     2100

gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat     2160

acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt     2220

atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg     2280

cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt     2340

gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt     2400

tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg     2460

tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg     2520

agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc     2580

ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac tggaaagcgg     2640

gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc caggctttac     2700

actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa tttcacacag     2760

gaaacagcta tgaccatgat tacgccaagc gcgcaattaa ccctcactaa agggaacaaa     2820

agctggagct gcaagcttaa tgtagtctta tgcaatactc ttgtagtctt gcaacatggt     2880

aacgatgagt tagcaacatg ccttacaagg agagaaaaag caccgtgcat gccgattggt     2940

ggaagtaagg tggtacgatc gtgccttatt aggaaggcaa cagacgggtc tgacatggat     3000

tggacgaacc actgaattgc cgcattgcag agatattgta tttaagtgcc tagctcgata     3060

cataaacggg tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg     3120

gaacccactg cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg     3180

tctgttgtgt gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat     3240

ctctagcagt ggcgcccgaa cagggacttg aaagcgaaag ggaaaccaga ggagctctct     3300

cgacgcagga ctcggcttgc tgaagcgcgc acggcaagag gcgaggggcg gcgactggtg     3360

agtacgccaa aaattttgac tagcggaggc tagaaggaga gagatgggtg cgagagcgtc     3420

agtattaagc gggggagaat tagatcgcga tgggaaaaaa ttcggttaag gccaggggga     3480

aagaaaaaat ataaattaaa acatatagta tgggcaagca gggagctaga acgattcgca     3540

gttaatcctg gcctgttaga aacatcagaa ggctgtagac aaatactggg acagctacaa     3600

ccatcccttc agacaggatc agaagaactt agatcattat ataatacagt agcaaccctc     3660

tattgtgtgc atcaaaggat agagataaaa gacaccaagg aagctttaga caagatagag     3720

gaagagcaaa acaaaagtaa gaccaccgca cagcaagcgg ccgctgatct tcagacctgg     3780

aggaggagat atgagggaca attggagaag tgaattatat aaatataaag tagtaaaaat     3840

tgaaccatta ggagtagcac ccaccaaggc aaagagaaga gtggtgcaga gagaaaaaag     3900

agcagtggga ataggagctt tgttccttgg gttcttggga gcagcaggaa gcactatggg     3960

cgcagcgtca atgacgctga cggtacaggc cagacaatta ttgtctggta tagtgcagca     4020

gcagaacaat ttgctgaggg ctattgaggc gcaacagcat ctgttgcaac tcacagtctg     4080

gggcatcaag cagctccagg caagaatcct ggctgtggaa agatacctaa aggatcaaca     4140

gctcctgggg atttggggtt gctctggaaa actcatttgc accactgctg tgccttggaa     4200

tgctagttgg agtaataaat ctctggaaca gatttggaat cacacgacct ggatggagtg     4260

ggacagagaa attaacaatt acacaagctt aatacactcc ttaattgaag aatcgcaaaa     4320

ccagcaagaa aagaatgaac aagaattatt ggaattagat aaatgggcaa gtttgtggaa     4380

ttggtttaac ataacaaatt ggctgtggta tataaaatta ttcataatga tagtaggagg     4440

cttggtaggt ttaagaatag tttttgctgt actttctata gtgaatagag ttaggcaggg     4500

atattcacca ttatcgtttc agacccacct cccaaccccg aggggacccg acaggcccga     4560

aggaatagaa gaagaaggtg gagagagaga cagagacaga tccattcgat tagtgaacgg     4620

atctcgacgg tatcgattag actgtagccc aggaatatgg cagctagatt gtacacattt     4680

agaaggaaaa gttatcttgg tagcagttca tgtagccagt ggatatatag aagcagaagt     4740

aattccagca gagacagggc aagaaacagc atacttcctc ttaaaattag caggaagatg     4800

gccagtaaaa acagtacata cagacaatgg cagcaatttc accagtacta cagttaaggc     4860

cgcctgttgg tgggcgggga tcaagcagga atttggcatt ccctacaatc cccaaagtca     4920

aggagtaata gaatctatga ataaagaatt aaagaaaatt ataggacagg taagagatca     4980

ggctgaacat cttaagacag cagtacaaat ggcagtattc atccacaatt ttaaaagaaa     5040

aggggggatt ggggggtaca gtgcagggga aagaatagta gacataatag caacagacat     5100

acaaactaaa gaattacaaa aacaaattac aaaaattcaa aattttcggg tttattacag     5160

ggacagcaga gatccagttt ggctgcattg atcacgtgag gctccggtgc ccgtcagtgg     5220

gcagagcgca catcgcccac agtccccgag aagttggggg gaggggtcgg caattgaacc     5280

ggtgcctaga gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc     5340

ctttttcccg agggtggggg agaaccgtat ataagtgcag tagtcgccgt gaacgttctt     5400

tttcgcaacg ggtttgccgc cagaacacag gtaagtgccg tgtgtggttc ccgcgggcct     5460

ggcctcttta cgggttatgg cccttgcgtg ccttgaatta cttccacctg gctgcagtac     5520

gtgattcttg atcccgagct tcgggttgga agtgggtggg agagttcgag gccttgcgct     5580

taaggagccc cttcgcctcg tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc     5640

gtgcgaatct ggtggcacct tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt     5700

taaaattttt gatgacctgc tgcgacgctt tttttctggc aagatagtct tgtaaatgcg     5760

ggccaagatc tgcacactgg tatttcggtt tttggggccg cgggcggcga cggggcccgt     5820

gcgtcccagc gcacatgttc ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga     5880

cgggggtagt ctcaagctgg ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc     5940

gccccgccct gggcggcaag gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg     6000

ccgcttcccg gccctgctgc agggagctca aaatggagga cgcggcgctc gggagagcgg     6060

gcgggtgagt cacccacaca aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt     6120

gactccactg agtaccgggc gccgtccagg cacctcgatt agttctcgag cttttggagt     6180

acgtcgtctt taggttgggg ggaggggttt tatgcgatgg agtttcccca cactgagtgg     6240

gtggagactg aagttaggcc agcttggcac ttgatgtaat tctccttgga atttgccctt     6300

tttgagtttg gatcttggtt cattctcaag cctcagacag tggttcaaag tttttttctt     6360

ccatttcagg tgtcgtgatc tagaggatcc atggccttac cagtgaccgc cttgctcctg     6420

ccgctggcct tgctgctcca cgccgccagg ccggacatcc agatgacaca gactacatcc     6480

tccctgtctg cctctctggg agacagagtc accatcagtt gcagggcaag tcaggacatt     6540

agtaaatatt taaattggta tcagcagaaa ccagatggaa ctgttaaact cctgatctac     6600

catacatcaa gattacactc aggagtccca tcaaggttca gtggcagtgg gtctggaaca     6660

gattattctc tcaccattag caacctggag caagaagata ttgccactta cttttgccaa     6720

cagggtaata cgcttccgta cacgttcgga ggggggacca agctggagat cacaggtggc     6780

ggtggctcgg gcggtggtgg gtcgggtggc ggcggatctg aggtgaaact gcaggagtca     6840

ggacctggcc tggtggcgcc ctcacagagc ctgtccgtca catgcactgt ctcaggggtc     6900

tcattacccg actatggtgt aagctggatt cgccagcctc cacgaaaggg tctggagtgg     6960

ctgggagtaa tatggggtag tgaaaccaca tactataatt cagctctcaa atccagactg     7020

accatcatca aggacaactc caagagccaa gttttcttaa aaatgaacag tctgcaaact     7080

gatgacacag ccatttacta ctgtgccaaa cattattact acggtggtag ctatgctatg     7140

gactactggg gccaaggaac ctcagtcacc gtctcctcaa ccacgacgcc agcgccgcga     7200

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc     7260

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac     7320

atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt     7380

tactgcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     7440

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     7500

ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta caagcagggc     7560

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     7620

aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa     7680

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     7740

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     7800

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta agtcgacaat     7860

caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta tgttgctcct     7920

tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc ttcccgtatg     7980

gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga ggagttgtgg     8040

cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac ccccactggt     8100

tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc cctccctatt     8160

gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc tcggctgttg     8220

ggcactgaca attccgtggt gttgtcgggg aagctgacgt cctttccatg gctgctcgcc     8280

tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc ggccctcaat     8340

ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc gcgtcttcgc     8400

cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcctgg aattcgagct     8460

cggtaccttt aagaccaatg acttacaagg cagctgtaga tcttagccac tttttaaaag     8520

aaaagggggg actggaaggg ctaattcact cccaacgaag acaagatctg ctttttgctt     8580

gtactgggtc tctctggtta gaccagatct gagcctggga gctctctggc taactaggga     8640

acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc     8700

tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct     8760

ctagcagtag tagttcatgt catcttatta ttcagtattt ataacttgca aagaaatgaa     8820

tatcagagag tgagaggaac ttgtttattg cagcttataa tggttacaaa taaagcaata     8880

gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca     8940

aactcatcaa tgtatcttat catgtctggc tctagctatc ccgcccctaa ctccgcccat     9000

cccgccccta actccgccca gttccgccca ttctccgccc catggctgac taattttttt     9060

tatttatgca gaggccgagg ccgcctcggc ctctgagcta ttccagaagt agtgaggagg     9120

cttttttgga ggcctaggga cgtacccaat tcgccctata gtgagtcgta ttac           9174


<210>  2
<211>  228
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  2
atgtagtctt atgcaatact cttgtagtct tgcaacatgg taacgatgag ttagcaacat       60

gccttacaag gagagaaaaa gcaccgtgca tgccgattgg tggaagtaag gtggtacgat      120

cgtgccttat taggaaggca acagacgggt ctgacatgga ttggacgaac cactgaattg      180

ccgcattgca gagatattgt atttaagtgc ctagctcgat acataaac                   228


<210>  3
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  3
gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca       60

ctgcttaagc ctcaataaag cttgccttga gtgcttca                               98


<210>  4
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  4
agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta       60

gtcagtgtgg aaaatctcta gcagt                                             85


<210>  5
<211>  1377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  5
cgaacaggga cttgaaagcg aaagggaaac cagaggagct ctctcgacgc aggactcggc       60

ttgctgaagc gcgcacggca agaggcgagg ggcggcgact ggtgagtacg ccaaaaattt      120

tgactagcgg aggctagaag gagagagatg ggtgcgagag cgtcagtatt aagcggggga      180

gaattagatc gcgatgggaa aaaattcggt taaggccagg gggaaagaaa aaatataaat      240

taaaacatat agtatgggca agcagggagc tagaacgatt cgcagttaat cctggcctgt      300

tagaaacatc agaaggctgt agacaaatac tgggacagct acaaccatcc cttcagacag      360

gatcagaaga acttagatca ttatataata cagtagcaac cctctattgt gtgcatcaaa      420

ggatagagat aaaagacacc aaggaagctt tagacaagat agaggaagag caaaacaaaa      480

gtaagaccac cgcacagcaa gcggccgctg atcttcagac ctggaggagg agatatgagg      540

gacaattgga gaagtgaatt atataaatat aaagtagtaa aaattgaacc attaggagta      600

gcacccacca aggcaaagag aagagtggtg cagagagaaa aaagagcagt gggaatagga      660

gctttgttcc ttgggttctt gggagcagca ggaagcacta tgggcgcagc gtcaatgacg      720

ctgacggtac aggccagaca attattgtct ggtatagtgc agcagcagaa caatttgctg      780

agggctattg aggcgcaaca gcatctgttg caactcacag tctggggcat caagcagctc      840

caggcaagaa tcctggctgt ggaaagatac ctaaaggatc aacagctcct ggggatttgg      900

ggttgctctg gaaaactcat ttgcaccact gctgtgcctt ggaatgctag ttggagtaat      960

aaatctctgg aacagatttg gaatcacacg acctggatgg agtgggacag agaaattaac     1020

aattacacaa gcttaataca ctccttaatt gaagaatcgc aaaaccagca agaaaagaat     1080

gaacaagaat tattggaatt agataaatgg gcaagtttgt ggaattggtt taacataaca     1140

aattggctgt ggtatataaa attattcata atgatagtag gaggcttggt aggtttaaga     1200

atagtttttg ctgtactttc tatagtgaat agagttaggc agggatattc accattatcg     1260

tttcagaccc acctcccaac cccgagggga cccgacaggc ccgaaggaat agaagaagaa     1320

ggtggagaga gagacagaga cagatccatt cgattagtga acggatctcg acggtat        1377


<210>  6
<211>  547
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  6
tagactgtag cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct       60

tggtagcagt tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag      120

ggcaagaaac agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac      180

atacagacaa tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg      240

ggatcaagca ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta      300

tgaataaaga attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga      360

cagcagtaca aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt      420

acagtgcagg ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac      480

aaaaacaaat tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag      540

tttggct                                                                547


<210>  7
<211>  1178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  7
gctccggtgc ccgtcagtgg gcagagcgca catcgcccac agtccccgag aagttggggg       60

gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg cggggtaaac tgggaaagtg      120

atgtcgtgta ctggctccgc ctttttcccg agggtggggg agaaccgtat ataagtgcag      180

tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc cagaacacag gtaagtgccg      240

tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg ccttgaatta      300

cttccacctg gctgcagtac gtgattcttg atcccgagct tcgggttgga agtgggtggg      360

agagttcgag gccttgcgct taaggagccc cttcgcctcg tgcttgagtt gaggcctggc      420

ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct tcgcgcctgt ctcgctgctt      480

tcgataagtc tctagccatt taaaattttt gatgacctgc tgcgacgctt tttttctggc      540

aagatagtct tgtaaatgcg ggccaagatc tgcacactgg tatttcggtt tttggggccg      600

cgggcggcga cggggcccgt gcgtcccagc gcacatgttc ggcgaggcgg ggcctgcgag      660

cgcggccacc gagaatcgga cgggggtagt ctcaagctgg ccggcctgct ctggtgcctg      720

gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag gctggcccgg tcggcaccag      780

ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctgc agggagctca aaatggagga      840

cgcggcgctc gggagagcgg gcgggtgagt cacccacaca aaggaaaagg gcctttccgt      900

cctcagccgt cgcttcatgt gactccactg agtaccgggc gccgtccagg cacctcgatt      960

agttctcgag cttttggagt acgtcgtctt taggttgggg ggaggggttt tatgcgatgg     1020

agtttcccca cactgagtgg gtggagactg aagttaggcc agcttggcac ttgatgtaat     1080

tctccttgga atttgccctt tttgagtttg gatcttggtt cattctcaag cctcagacag     1140

tggttcaaag tttttttctt ccatttcagg tgtcgtga                             1178


<210>  8
<211>  1459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  8
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgct                                                  1459


<210>  9
<211>  591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  9
atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc       60

cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta      120

tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt      180

ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg      240

gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta      300

ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt      360

tgggcactga caattccgtg gtgttgtcgg ggaagctgac gtcctttcca tggctgctcg      420

cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca      480

atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc      540

gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgcct g               591


<210>  10
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthezied

<400>  10
gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca       60

ctgcttaagc ctcaataaag cttgccttga gtgcttca                               98


<210>  11
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  11
agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta       60

gtcagtgtgg aaaatctcta gcag                                              84


<210>  12
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  12

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  13
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  13
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  14
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  14
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggagatcac aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc      360

ggatctgagg tgaaactgca ggagtcagga cctggcctgg tggcgccctc acagagcctg      420

tccgtcacat gcactgtctc aggggtctca ttacccgact atggtgtaag ctggattcgc      480

cagcctccac gaaagggtct ggagtggctg ggagtaatat ggggtagtga aaccacatac      540

tataattcag ctctcaaatc cagactgacc atcatcaagg acaactccaa gagccaagtt      600

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tttactactg tgccaaacat      660

tattactacg gtggtagcta tgctatggac tactggggcc aaggaacctc agtcaccgtc      720

tcctca                                                                 726


<210>  15
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  15
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  16
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  16
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  17
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  17
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  18
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  18
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  19
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  19

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  20
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  20

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  21
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  21

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45          


<210>  22
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  22

Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
1               5                   10                  15      


Val Ile Thr Leu Tyr Cys 
            20          


<210>  23
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  23

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  24
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  24

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  25
gaaagctgac tgcccctatt tg                                                22


<210>  26
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  26
gagaggaagt gctgggaaca at                                                22


<210>  27
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  27
ctccccagtc tcttt                                                        15


