                         SEQUENCE LISTING

<110>  UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
       ZARBL, Helmut
       GRAHAM, Jessica
 
<120>  Novel Method of Cancer Diagnosis and Prognosis and Prediction of 
       Response to Therapy

<130>  096738.00204

<150>  61/419,975
<151>  2010-12-06

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  10718
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  1
agggggcggc gctcccggcc catcccttag ccccgcggcg gccgtgtggg ccggaggctg       60

cctgcaccgc gtcagggagg ccggcctaga aaccctccct cccagaagaa agccgatccc      120

agttcaggtg gggtcttcct cggttgcgta cctggctgga gccgagctgg tgggcggccg      180

gcagccggcg tttctggtga tgacagcccc gaaatgaaag cagcgcggcc gccgcctccg      240

agggctgcag ggagatcagc gtccagcaaa taagaagcaa gtcctggacc cggaggagga      300

ggagcggccg agcatctctc tctgctccgc cgtgtccttt agatgagcac tcccggccgg      360

agccggaggt ggatccgcag agctgcctct gggcgcctga ccccgcgctg acatcacaac      420

ctgtgacagg cgcatcacgc ccggtacctg ctcccggccg ctgcccgtcc tcccagcctc      480

tttgtatgcc gcagacatgg ccagccagca ggattcgggc ttctttgaga tcagtatcaa      540

atatttactg aaatcctgga gtaatacttc tcccgttggc aacggttaca tcaagcctcc      600

ggttccacct gcttctggca cgcacaggga gaaagggccg ccaaccatgc tacccatcaa      660

tgtggaccca gacagtaaac caggagaata tgtcctcaaa agtttatttg tcaacttcac      720

cactcaggct gaacgcaaga ttcgtatcat tatggcagag cccctggaaa agccattgac      780

aaaatctctg caacgtggag aagaccccca atttgatcag gtcatcagct caatgagctc      840

cctttctgag tactgcctgc cttccattct acgtacatta tttgactggt ataaaaggca      900

aaatggcatt gaggatgaat cacatgaata cagaccaaga acaagcaata aatcaaaaag      960

cgatgaacaa cagcgagatt atttaatgga aagacgggac ctcgccattg attttatttt     1020

ttctttagta ttaatagaag ttttgaaaca gattccactt catcctgtaa tagacagttt     1080

aatacatgat gttattaact tggctttcaa gcactttaaa tacaaagaag ggtaccttgg     1140

tcccaacact ggcaatatgc atattgtggc agacctgtat gcagaagtca ttggagtgtt     1200

ggcacaagcc aaattccctg ctgtaaagaa gaaatttatg gcggagctaa aagaattacg     1260

gcacaaagag cagaacccat atgtggttca aagcattatc agcttaataa tgggcatgaa     1320

attctttcga attaagatgt atccagtgga ggattttgag gcctctcttc agtttatgca     1380

ggaatgtgca cattacttcc tcgaggtcaa agacaaagat atcaagcatg ccttggctgg     1440

gctttttgtt gaaatacttg ttccagttgc tgctgctgtt aaaaatgaag taaatgttcc     1500

ctgccttaga aattttgtgg aaagcctgta tgacaccacg ctggaacttt cttctcgaaa     1560

gaagcattcc ttggccttgt accccctggt gacctgtttg ctctgtgtca gtcagaagca     1620

gctgttcctg aacaggtggc acattttcct caacaactgc ttgtccaacc ttaaaaacaa     1680

agatcccaag atggctcgag ttgcactgga atctctctac agattacttt gggtttacat     1740

gattcgaatt aaatgtgaaa gcaacacagc tactcagagc cgacttataa ccatcatcac     1800

aacacttttc cccaaagggt cccgcggtgt ggtaccaagg gacatgcctc tgaacatctt     1860

tgtgaaaatc atccagttca ttgcccagga acgtttagat tttgcaatga aagaaatcat     1920

tttcgatttt ctttgtgtgg gaaaaccagc aaaagcattc agtctcaacc cagagagaat     1980

gaacattggt ttacgggcat tcttggtcat agctgatagc ttgcagcaga aagatgggga     2040

acctcccatg ccggttacag gagccgttct tccttcagga aacacgttaa gagtaaagaa     2100

aacatatttg agtaaaacac taactgaaga ggaagccaaa atgataggca tgtccttata     2160

ttactctcaa gtacgaaaag ctgtagacaa cattttaagg caccttgata aagaagtagg     2220

aaggtgtatg atgctgacta atgtacagat gttaaacaaa gaaccggaag acatgatcac     2280

gggtgagaga aagccaaaaa tagatctttt caggacctgt gttgctgcta ttcctcgact     2340

gcttcctgat gggatgtcaa aacttgaact tattgactta ctggctaggc tctctattca     2400

tatggatgat gaattgcgac atattgcaca aaattctctt cagggtttac ttgttgactt     2460

ctcagattgg agggaagatg tactatttgg ctttaccaac ttcctgctcc gggaagtaaa     2520

tgatatgcat cacacactcc ttgattcgtc cctgaagttg ctgctgcagc tgctcaccca     2580

gtggaaacta gtcatccaga cacaaggaaa agtctatgaa caagccaaca aaatcagaaa     2640

ttcagagctc atcgcaaatg gctccagtca cagaattcag tcggaacgag gtccccactg     2700

cagtgtactc cacgctgtag aaggttttgc tctggtttta ctctgcagtt tccaggtggc     2760

cacacgcaaa ctgtccgttt taatactcaa ggaaattcga gcgttgttta ttgccctggg     2820

gcagcctgag gatgacgaca ggccgatgat tgatgtcatg gatcagctaa gttcttccat     2880

tctagaaagt tttattcatg tagcagtttc ggattcagca acattaccac tcacccacaa     2940

tgtggatctg cagtggttgg tggaatggaa cgcagtcctg gtcaatagcc attatgatgt     3000

gaaaagccct tcccatgtct ggatatttgc acagtctgtc aaagacccct gggtcctctg     3060

cctcttcagc ttcctccggc aggagaactt acccaagcac tgccccacag ccctcagcta     3120

tgcctggcct tatgccttca ctcggctcca gtcggtgatg cctctggtgg acccaaatag     3180

cccaattaat gccaagaaaa ccagcactgc cggcagcgga gacaactatg ttactttgtg     3240

gagaaattac ctaattcttt gttttggagt tgcaaaaccc agtattatga gcccaggaca     3300

cttaagagct tccactccag aaataatggc gaccacacct gatggtacag tgagctacga     3360

taacaaggcc ataggcaccc catcggtggg agttctgtta aagcagttgg tgcctttgat     3420

gagactagag agcattgaga tcacagagtc cttagtttta ggatttggaa gaacaaattc     3480

ccttgttttc agagaattgg tagaagaact tcatccatta atgaaagaag ctctggaaag     3540

aagaccagag aacaagaaac gccgagaacg gcgagacttg ttaaggctac aactacttcg     3600

aatttttgaa cttttggctg atgctggtgt aataagtgac agcacaaatg gagccctaga     3660

gcgggatact ttagccctgg gagctttgtt cttagaatat gtggacttga cccgcatgct     3720

cctagaagct gaaaatgaca aagaagttga aattcttaaa gatatccggg cacattttag     3780

tgcaatggtg gccaacttga ttcagtgtgt tccagttcac caccgaagat ttctcttccc     3840

ccagcaaagt ctgaggcacc accttttcat cttattcagc cagtgggcag gacccttcag     3900

cattatgttc actcctctgg atcgttacag tgacagaaat catcagatta caagatatca     3960

gtattgtgca ttaaaagcaa tgtcagcagt actgtgctgt ggccctgtct ttgacaatgt     4020

gggcctttcc ccagatggct acctatataa atggcttgac aacattctgg cttgtcaaga     4080

tttacgagtt catcaacttg gctgcgaagt tgttgtcttg ctactggaac ttaatcctga     4140

ccaaataaat ctttttaact gggcaattga ccgatgctac acaggttcct accaacttgc     4200

atctggctgc ttcaaagcca tagcaactgt gtgtggaagc aggaactatc ccttcgacat     4260

agtgacattg ttaaaccttg ttctattcaa ggcctctgac accaacagag agatttatga     4320

aatctccatg cagctcatgc agatccttga agcaaagctt tttgtatact caaagaaagt     4380

cgctgagcaa agaccgggaa gtattctcta tggaacacac ggcccgctgc cacccctcta     4440

cagcgtgtca cttgccctct tgtcatgtga gctggccagg atgtaccctg agctcacact     4500

ccccctcttc tcagaggtaa gccagcgatt ccccacaaca caccccaacg ggcgccagat     4560

catgcttacc tacctgctgc cctggctgca caacatcgag ctggtggaca gcaggctcct     4620

cctcccgggg tcgagcccca gcagcccaga ggacgaagtc aaggaccggg aaggtgacgt     4680

gactgcttct cacgggctga gaggaaatgg ctggggctct ccagaagcca cgtcactggt     4740

cctgaacaac ctcatgtaca tgacggccaa gtatggagat gaagttcctg ggccagaaat     4800

ggaaaatgct tggaatgctt tagccaacaa tgagaaatgg agcaacaacc tgaggatcac     4860

cttgcagttc ctgattagcc tctgtggggt cagcagcgac acagttctcc taccctatat     4920

taaaaaagtg gcaatatact tgtgccgtaa caacaccatt caaaccatgg aagagcttct     4980

ctttgagctg cagcagacag agcccgtgaa ccccatcgtc cagcattgtg acaacccgcc     5040

cttctaccgc ttcacggcca gtagcaaggc ttccgcagca gcctcaggaa ccacctctag     5100

cagcaataca gtggttgctg gccaggaaaa tttcccagat gctgaggaga acaagatatt     5160

gaaagaatct gatgaaaggt ttagtaatgt catcagagcc cacactcgcc tcgagtcaag     5220

atacagcaat agctctggag gatcctacga tgaagataaa aatgatccaa tttctcccta     5280

cacgggctgg ttgctgacta ttacagagac caagcagccg cagcccttac cgatgccttg     5340

tactggagga tgctgggccc ccctggttga ctatctcccg gagaccatca ctccccgggg     5400

gccactccac aggtgcaata ttgctgtaat ttttatgact gaaatggtgg tggatcacag     5460

tgtacgagaa gactgggcgc ttcatctacc attattactt catgctgtct tcttaggttt     5520

agaccactac cggcctgaag tctttgaaca cagcaaaaaa ctgcttcttc acctcttgat     5580

tgccctctct tgcaacagca atttccattc cattgcttcc gtgctcctgc agacccgaga     5640

gatgggtgaa gctaagactc taaccgtgca gccagcctac caacctgaat atctctatac     5700

aggtggcttt gacttcctga gagaggacca gtcatccccg gtgcctgact cagggcttag     5760

ttcaagctcc acctcctcta gcatcagtct gggaggcagc agtggaaacc tcccacagat     5820

gacccaggag gtagaagatg tggacacagc tgctgaaaca gatgagaagg caaacaagct     5880

cattgagttt ctcacgacca gggcatttgg tccactttgg tgccatgaag acatcacacc     5940

taaaaatcaa aattcaaaga gtgctgaaca gctcactaat tttctacgtc acgttgtatc     6000

tgtatttaaa gattccaaat caggcttcca tctggagcac cagttgagtg aagttgcatt     6060

gcagacagcc ctcgcaagct cttcaaggca ctatgctggt cggtccttcc agatattccg     6120

ggccctcaag caacctctgt cagcacatgc cttatctgac cttctctcaa gattggtgga     6180

ggtgatagga gaacatggag atgagattca gggttatgta atggaagcgc tcctaacctt     6240

ggaggcggct gtggataact tgtctgactg cttgaagaac agtgacctcc taactgtatt     6300

gtcccgctct tcctcaccag atttaagctc cagcagtaaa ctaacagcaa gcagaaagag     6360

cacaggacaa ctaaacatga acccgggaac caccagcggc aacaccgcaa ctgccgaacg     6420

gagccggcat caacgaagct tctctgtgcc caagaagttt ggtgtcatcg accgatcctc     6480

tgacccacct cgaagtgcca cactggacag aattcaggct tgtacccaac aaggcctctc     6540

ctcaaaaacc agaagctcat cctccttgaa ggacagtctc acggacccat cccacataaa     6600

ccatcccacc aacctgctgg ccaccatatt ctgggtcaca gtggccttga tggagtctga     6660

ttttgagttt gaatacttaa tggccttaag gctgttgagc agactactgg cacatatgcc     6720

actcgataag gctgagaacc gagaaaagct tgagaaactc caggcacagc tgaagtgggc     6780

cgacttctcc gggctgcagc agctgctgct gaaaggattc acatccctca ccaccacaga     6840

cctgaccctg cagctcttca gtctgctgac accagtgtcc aaaatatcca tggtggatgc     6900

atcccacgct attgggtttc cactgaatgt cttgtgtctc ctgcctcagc tgattcagca     6960

ttttgaaaat cccaatcagt tctgtaagga tatagccgaa aggattgctc aggtttgttt     7020

agaagagaag aaccccaaac tttcaaatct tgcacatgtc atgactcttt ataaaacgca     7080

cagctacacg agggactgtg ccacgtgggt caatgtggtc tgtcgatacc ttcatgaagc     7140

atatgctgac attaccttga atatggttac ctacctggca gagctgctgg agaagggcct     7200

ccctagtgtg cagcagcccc tgctccaggt gatctacagt cttctcagct acatggacct     7260

ttctgtcgtt cctgtcaaac agttcaatgt ggaagttctg aagacaattg aaaaatatgt     7320

gcaaagtgtt cactggagag aagctctgaa tatcttgaag ctggtagttt ctcggtcagc     7380

cagccttgtt ttaccttcat accagcacag tgacctctca aaaatagaaa tacatcgagt     7440

gtggactagt gcttccaagg aattacctgg gaaaaccctg gacttccact tcgatatttc     7500

ggagactcca atcatcggga ggcggtatga tgagctgcag aattcttctg ggcgtgatgg     7560

gaagcccagg gccatggccg tcacccggag cacatcttcc acttcctcag gctccaactc     7620

caacgtcctt gttccagtga gctggaaaag gccccagtat tctcagaaga gaacaaaaga     7680

gaagttggta catgtccttt ctctgtgtgg ccaagaagta ggattgagca aaaatccatc     7740

agtgattttt tcatcgtgtg gggatctgga tctgcttgag caccagacaa gcttggtatc     7800

ttctgaggac ggtgcccgag agcaggagaa catggatgac acaaacagcg agcagcagtt     7860

tagagtcttc agagacttcg acttcctaga tgtggagctg gaggatggag agggtgagag     7920

tatggacaat ttcaactggg gagtgcgcag acgttctctg gacagcctgg ataagtgtga     7980

tatgcagatt ctggaggagc gccaactgtc aggaagcact cctagcctga ataaaatgca     8040

ccatgaggac tccgatgaat catccgagga ggaggacctc acagccagcc agatcctgga     8100

gcactcagac ctaatcatga ctctctcccc ctctgaagag acgaatccca tggagctgct     8160

caccacagcc tgtgactcga cccctgcaga acctcattcc tttaacacca gaatgtccag     8220

ctttgatgct tccttgcctg atatgaataa tctgcagatt tctgagggtt caaaggctga     8280

agctgttcgt gaggaggagg acaccaccgt gcatgaggat gatctttcta gttccatcaa     8340

tgaactccca gcagcttttg aatgcagcga cagctttagc ctggacatga ctgaggggga     8400

agaaaaaggc aatcgggcac tggaccagtt taccctggcg agctttggag aaggtgacag     8460

gggagtctct ccccctccct cgcccttctt ctcagccatc cttgccgcct ttcagcccgc     8520

agcctgtgac gatgccgagg aggcctggcg cagccacatc aaccagctta tgtgtgactc     8580

agatggctcc tgtgctgtgt atacatttca tgtgttctcc tccttgttta agaatattca     8640

gaaaaggttc tgcttcctaa cctgtgatgc agccagttac cttggagata acctccgggg     8700

aatcggatcc aaatttgtca gctcttccca gatgctcacc tcctgctctg aatgtcctac     8760

actttttgtg gatgccgaga ctctcctttc atgtggactt ctggacaagc tcaagttcag     8820

tgtgttagaa ctgcaagaat atttggatac ctacaacaac aggaaagagg ccacactctc     8880

ttggcttgca aattgtaagg caacatttgc agggggatca agagatggag taattacctg     8940

tcaaccaggg gactccgaag aaaagcaatt ggaactgtgt cagagattat ataagctaca     9000

cttccagctg ctattgcttt ttcagtccta ctgtaagctc atcggccagg tgcacgaagt     9060

tagctccatg ccagagctgc tgaatatgtc cagggaactg agtgacctaa agaaacacct     9120

gaaggaagcc agtgcagtca ttgcagctga ccctctctat tcagacggcg cgtggtccga     9180

gcccaccttc acgtccactg aagcagccat ccagtccatg ctggagtgcc tgaagaacaa     9240

cgaactcggc aaagctttgc ggcagatcag ggagtgcaga agtctgtggc ccaatgacat     9300

ctttggaagc agttctgatg atgaggtcca gacactactg aatatttatt tccgtcacca     9360

aactctggga cagacgggta cttatgccct ggtggggtct aaccagagcc tgaccgagat     9420

ctgcaccaag ctgatggagc tgaacatgga gatccgggac atgatccgca gggcccagag     9480

ttaccgagtc ctcactactt ttcttccaga ctccagtgtt tctggcacta gtctctgaca     9540

ggagcctcct gtccccactg ggttccaaac tggcagtgct gccatgctgg ggcaacgtca     9600

ttcagtgtct tctcggcctt caaaaggctt ggacagactg ttctccctct tgttacctgt     9660

agggcttttt ctaaagagga tggcagaact tccaacgtgt agcaatacta taagaaccaa     9720

ggtagcttag aacgtcctgg acagactcca ctcatcatgc tgtgtggcac aaatgtgtta     9780

catttgaccg agcatatgca actcgctact gaagaagtga cttccgttgc ataccaaagc     9840

cgactacact gaacagtacc ttcctttcta gaaacaattt tagattggca aaagtgcaat     9900

gttttcttca ctcaaaaaat tttatattct caaacatgta tattctttcc ctgtcttgtt     9960

ccattttctt ttcttttttc ttttttcttt ttcctttctt tcgtgggctg agaaaggggc    10020

aggcaaaatg aagctggcca ctgaaaactg taagatggtc aaaagctgac agcctgtgta    10080

tgtgaaaagg gaattgtaaa tggactgcaa tgtaatgtac actgtaattt gaatacaatt    10140

actgtatcta aaaggagctg ctatgaagta cctttcttat gttgctaggc tactgtttct    10200

gaaagccctg gatctctttg caccaaaaat ggtccagata gactcttttt aaggatcttg    10260

gctgcttttt actagaaggt tgcttttatg agcatattta tactgctgaa ggatgagtgt    10320

taattttaat taactttgcc gttttgtaga gaaaactatt cacaagataa attccaagtc    10380

ttttcacctg tcaggcatgc atattttaat atctgtttgg atagtcagaa gtagaatcat    10440

aaaggtaaaa tatgagttgt tactttgttt cttcgatgtc atattttatg tgtaatatat    10500

atgtaaaggg ccattcttaa gttctctcct taaacttaat gctgtcaagt gttagatgtg    10560

tgcatgtgaa cttgttgcac tgcagaaaca tattcagagt ttatctatgt aacttattca    10620

ctctgtaaat acatttaaag tttttgtgat gtaagcttaa ttgatattct gttcagaact    10680

ttctttagac taaaaaaaaa aaaaaagaca aaatacaa                            10718


<210>  2
<211>  3013
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  2

Met Ala Ser Gln Gln Asp Ser Gly Phe Phe Glu Ile Ser Ile Lys Tyr 
1               5                   10                  15      


Leu Leu Lys Ser Trp Ser Asn Thr Ser Pro Val Gly Asn Gly Tyr Ile 
            20                  25                  30          


Lys Pro Pro Val Pro Pro Ala Ser Gly Thr His Arg Glu Lys Gly Pro 
        35                  40                  45              


Pro Thr Met Leu Pro Ile Asn Val Asp Pro Asp Ser Lys Pro Gly Glu 
    50                  55                  60                  


Tyr Val Leu Lys Ser Leu Phe Val Asn Phe Thr Thr Gln Ala Glu Arg 
65                  70                  75                  80  


Lys Ile Arg Ile Ile Met Ala Glu Pro Leu Glu Lys Pro Leu Thr Lys 
                85                  90                  95      


Ser Leu Gln Arg Gly Glu Asp Pro Gln Phe Asp Gln Val Ile Ser Ser 
            100                 105                 110         


Met Ser Ser Leu Ser Glu Tyr Cys Leu Pro Ser Ile Leu Arg Thr Leu 
        115                 120                 125             


Phe Asp Trp Tyr Lys Arg Gln Asn Gly Ile Glu Asp Glu Ser His Glu 
    130                 135                 140                 


Tyr Arg Pro Arg Thr Ser Asn Lys Ser Lys Ser Asp Glu Gln Gln Arg 
145                 150                 155                 160 


Asp Tyr Leu Met Glu Arg Arg Asp Leu Ala Ile Asp Phe Ile Phe Ser 
                165                 170                 175     


Leu Val Leu Ile Glu Val Leu Lys Gln Ile Pro Leu His Pro Val Ile 
            180                 185                 190         


Asp Ser Leu Ile His Asp Val Ile Asn Leu Ala Phe Lys His Phe Lys 
        195                 200                 205             


Tyr Lys Glu Gly Tyr Leu Gly Pro Asn Thr Gly Asn Met His Ile Val 
    210                 215                 220                 


Ala Asp Leu Tyr Ala Glu Val Ile Gly Val Leu Ala Gln Ala Lys Phe 
225                 230                 235                 240 


Pro Ala Val Lys Lys Lys Phe Met Ala Glu Leu Lys Glu Leu Arg His 
                245                 250                 255     


Lys Glu Gln Asn Pro Tyr Val Val Gln Ser Ile Ile Ser Leu Ile Met 
            260                 265                 270         


Gly Met Lys Phe Phe Arg Ile Lys Met Tyr Pro Val Glu Asp Phe Glu 
        275                 280                 285             


Ala Ser Leu Gln Phe Met Gln Glu Cys Ala His Tyr Phe Leu Glu Val 
    290                 295                 300                 


Lys Asp Lys Asp Ile Lys His Ala Leu Ala Gly Leu Phe Val Glu Ile 
305                 310                 315                 320 


Leu Val Pro Val Ala Ala Ala Val Lys Asn Glu Val Asn Val Pro Cys 
                325                 330                 335     


Leu Arg Asn Phe Val Glu Ser Leu Tyr Asp Thr Thr Leu Glu Leu Ser 
            340                 345                 350         


Ser Arg Lys Lys His Ser Leu Ala Leu Tyr Pro Leu Val Thr Cys Leu 
        355                 360                 365             


Leu Cys Val Ser Gln Lys Gln Leu Phe Leu Asn Arg Trp His Ile Phe 
    370                 375                 380                 


Leu Asn Asn Cys Leu Ser Asn Leu Lys Asn Lys Asp Pro Lys Met Ala 
385                 390                 395                 400 


Arg Val Ala Leu Glu Ser Leu Tyr Arg Leu Leu Trp Val Tyr Met Ile 
                405                 410                 415     


Arg Ile Lys Cys Glu Ser Asn Thr Ala Thr Gln Ser Arg Leu Ile Thr 
            420                 425                 430         


Ile Ile Thr Thr Leu Phe Pro Lys Gly Ser Arg Gly Val Val Pro Arg 
        435                 440                 445             


Asp Met Pro Leu Asn Ile Phe Val Lys Ile Ile Gln Phe Ile Ala Gln 
    450                 455                 460                 


Glu Arg Leu Asp Phe Ala Met Lys Glu Ile Ile Phe Asp Phe Leu Cys 
465                 470                 475                 480 


Val Gly Lys Pro Ala Lys Ala Phe Ser Leu Asn Pro Glu Arg Met Asn 
                485                 490                 495     


Ile Gly Leu Arg Ala Phe Leu Val Ile Ala Asp Ser Leu Gln Gln Lys 
            500                 505                 510         


Asp Gly Glu Pro Pro Met Pro Val Thr Gly Ala Val Leu Pro Ser Gly 
        515                 520                 525             


Asn Thr Leu Arg Val Lys Lys Thr Tyr Leu Ser Lys Thr Leu Thr Glu 
    530                 535                 540                 


Glu Glu Ala Lys Met Ile Gly Met Ser Leu Tyr Tyr Ser Gln Val Arg 
545                 550                 555                 560 


Lys Ala Val Asp Asn Ile Leu Arg His Leu Asp Lys Glu Val Gly Arg 
                565                 570                 575     


Cys Met Met Leu Thr Asn Val Gln Met Leu Asn Lys Glu Pro Glu Asp 
            580                 585                 590         


Met Ile Thr Gly Glu Arg Lys Pro Lys Ile Asp Leu Phe Arg Thr Cys 
        595                 600                 605             


Val Ala Ala Ile Pro Arg Leu Leu Pro Asp Gly Met Ser Lys Leu Glu 
    610                 615                 620                 


Leu Ile Asp Leu Leu Ala Arg Leu Ser Ile His Met Asp Asp Glu Leu 
625                 630                 635                 640 


Arg His Ile Ala Gln Asn Ser Leu Gln Gly Leu Leu Val Asp Phe Ser 
                645                 650                 655     


Asp Trp Arg Glu Asp Val Leu Phe Gly Phe Thr Asn Phe Leu Leu Arg 
            660                 665                 670         


Glu Val Asn Asp Met His His Thr Leu Leu Asp Ser Ser Leu Lys Leu 
        675                 680                 685             


Leu Leu Gln Leu Leu Thr Gln Trp Lys Leu Val Ile Gln Thr Gln Gly 
    690                 695                 700                 


Lys Val Tyr Glu Gln Ala Asn Lys Ile Arg Asn Ser Glu Leu Ile Ala 
705                 710                 715                 720 


Asn Gly Ser Ser His Arg Ile Gln Ser Glu Arg Gly Pro His Cys Ser 
                725                 730                 735     


Val Leu His Ala Val Glu Gly Phe Ala Leu Val Leu Leu Cys Ser Phe 
            740                 745                 750         


Gln Val Ala Thr Arg Lys Leu Ser Val Leu Ile Leu Lys Glu Ile Arg 
        755                 760                 765             


Ala Leu Phe Ile Ala Leu Gly Gln Pro Glu Asp Asp Asp Arg Pro Met 
    770                 775                 780                 


Ile Asp Val Met Asp Gln Leu Ser Ser Ser Ile Leu Glu Ser Phe Ile 
785                 790                 795                 800 


His Val Ala Val Ser Asp Ser Ala Thr Leu Pro Leu Thr His Asn Val 
                805                 810                 815     


Asp Leu Gln Trp Leu Val Glu Trp Asn Ala Val Leu Val Asn Ser His 
            820                 825                 830         


Tyr Asp Val Lys Ser Pro Ser His Val Trp Ile Phe Ala Gln Ser Val 
        835                 840                 845             


Lys Asp Pro Trp Val Leu Cys Leu Phe Ser Phe Leu Arg Gln Glu Asn 
    850                 855                 860                 


Leu Pro Lys His Cys Pro Thr Ala Leu Ser Tyr Ala Trp Pro Tyr Ala 
865                 870                 875                 880 


Phe Thr Arg Leu Gln Ser Val Met Pro Leu Val Asp Pro Asn Ser Pro 
                885                 890                 895     


Ile Asn Ala Lys Lys Thr Ser Thr Ala Gly Ser Gly Asp Asn Tyr Val 
            900                 905                 910         


Thr Leu Trp Arg Asn Tyr Leu Ile Leu Cys Phe Gly Val Ala Lys Pro 
        915                 920                 925             


Ser Ile Met Ser Pro Gly His Leu Arg Ala Ser Thr Pro Glu Ile Met 
    930                 935                 940                 


Ala Thr Thr Pro Asp Gly Thr Val Ser Tyr Asp Asn Lys Ala Ile Gly 
945                 950                 955                 960 


Thr Pro Ser Val Gly Val Leu Leu Lys Gln Leu Val Pro Leu Met Arg 
                965                 970                 975     


Leu Glu Ser Ile Glu Ile Thr Glu Ser Leu Val Leu Gly Phe Gly Arg 
            980                 985                 990         


Thr Asn Ser Leu Val Phe Arg Glu  Leu Val Glu Glu Leu  His Pro Leu 
        995                 1000                 1005             


Met Lys  Glu Ala Leu Glu Arg  Arg Pro Glu Asn Lys  Lys Arg Arg 
    1010                 1015                 1020             


Glu Arg  Arg Asp Leu Leu Arg  Leu Gln Leu Leu Arg  Ile Phe Glu 
    1025                 1030                 1035             


Leu Leu  Ala Asp Ala Gly Val  Ile Ser Asp Ser Thr  Asn Gly Ala 
    1040                 1045                 1050             


Leu Glu  Arg Asp Thr Leu Ala  Leu Gly Ala Leu Phe  Leu Glu Tyr 
    1055                 1060                 1065             


Val Asp  Leu Thr Arg Met Leu  Leu Glu Ala Glu Asn  Asp Lys Glu 
    1070                 1075                 1080             


Val Glu  Ile Leu Lys Asp Ile  Arg Ala His Phe Ser  Ala Met Val 
    1085                 1090                 1095             


Ala Asn  Leu Ile Gln Cys Val  Pro Val His His Arg  Arg Phe Leu 
    1100                 1105                 1110             


Phe Pro  Gln Gln Ser Leu Arg  His His Leu Phe Ile  Leu Phe Ser 
    1115                 1120                 1125             


Gln Trp  Ala Gly Pro Phe Ser  Ile Met Phe Thr Pro  Leu Asp Arg 
    1130                 1135                 1140             


Tyr Ser  Asp Arg Asn His Gln  Ile Thr Arg Tyr Gln  Tyr Cys Ala 
    1145                 1150                 1155             


Leu Lys  Ala Met Ser Ala Val  Leu Cys Cys Gly Pro  Val Phe Asp 
    1160                 1165                 1170             


Asn Val  Gly Leu Ser Pro Asp  Gly Tyr Leu Tyr Lys  Trp Leu Asp 
    1175                 1180                 1185             


Asn Ile  Leu Ala Cys Gln Asp  Leu Arg Val His Gln  Leu Gly Cys 
    1190                 1195                 1200             


Glu Val  Val Val Leu Leu Leu  Glu Leu Asn Pro Asp  Gln Ile Asn 
    1205                 1210                 1215             


Leu Phe  Asn Trp Ala Ile Asp  Arg Cys Tyr Thr Gly  Ser Tyr Gln 
    1220                 1225                 1230             


Leu Ala  Ser Gly Cys Phe Lys  Ala Ile Ala Thr Val  Cys Gly Ser 
    1235                 1240                 1245             


Arg Asn  Tyr Pro Phe Asp Ile  Val Thr Leu Leu Asn  Leu Val Leu 
    1250                 1255                 1260             


Phe Lys  Ala Ser Asp Thr Asn  Arg Glu Ile Tyr Glu  Ile Ser Met 
    1265                 1270                 1275             


Gln Leu  Met Gln Ile Leu Glu  Ala Lys Leu Phe Val  Tyr Ser Lys 
    1280                 1285                 1290             


Lys Val  Ala Glu Gln Arg Pro  Gly Ser Ile Leu Tyr  Gly Thr His 
    1295                 1300                 1305             


Gly Pro  Leu Pro Pro Leu Tyr  Ser Val Ser Leu Ala  Leu Leu Ser 
    1310                 1315                 1320             


Cys Glu  Leu Ala Arg Met Tyr  Pro Glu Leu Thr Leu  Pro Leu Phe 
    1325                 1330                 1335             


Ser Glu  Val Ser Gln Arg Phe  Pro Thr Thr His Pro  Asn Gly Arg 
    1340                 1345                 1350             


Gln Ile  Met Leu Thr Tyr Leu  Leu Pro Trp Leu His  Asn Ile Glu 
    1355                 1360                 1365             


Leu Val  Asp Ser Arg Leu Leu  Leu Pro Gly Ser Ser  Pro Ser Ser 
    1370                 1375                 1380             


Pro Glu  Asp Glu Val Lys Asp  Arg Glu Gly Asp Val  Thr Ala Ser 
    1385                 1390                 1395             


His Gly  Leu Arg Gly Asn Gly  Trp Gly Ser Pro Glu  Ala Thr Ser 
    1400                 1405                 1410             


Leu Val  Leu Asn Asn Leu Met  Tyr Met Thr Ala Lys  Tyr Gly Asp 
    1415                 1420                 1425             


Glu Val  Pro Gly Pro Glu Met  Glu Asn Ala Trp Asn  Ala Leu Ala 
    1430                 1435                 1440             


Asn Asn  Glu Lys Trp Ser Asn  Asn Leu Arg Ile Thr  Leu Gln Phe 
    1445                 1450                 1455             


Leu Ile  Ser Leu Cys Gly Val  Ser Ser Asp Thr Val  Leu Leu Pro 
    1460                 1465                 1470             


Tyr Ile  Lys Lys Val Ala Ile  Tyr Leu Cys Arg Asn  Asn Thr Ile 
    1475                 1480                 1485             


Gln Thr  Met Glu Glu Leu Leu  Phe Glu Leu Gln Gln  Thr Glu Pro 
    1490                 1495                 1500             


Val Asn  Pro Ile Val Gln His  Cys Asp Asn Pro Pro  Phe Tyr Arg 
    1505                 1510                 1515             


Phe Thr  Ala Ser Ser Lys Ala  Ser Ala Ala Ala Ser  Gly Thr Thr 
    1520                 1525                 1530             


Ser Ser  Ser Asn Thr Val Val  Ala Gly Gln Glu Asn  Phe Pro Asp 
    1535                 1540                 1545             


Ala Glu  Glu Asn Lys Ile Leu  Lys Glu Ser Asp Glu  Arg Phe Ser 
    1550                 1555                 1560             


Asn Val  Ile Arg Ala His Thr  Arg Leu Glu Ser Arg  Tyr Ser Asn 
    1565                 1570                 1575             


Ser Ser  Gly Gly Ser Tyr Asp  Glu Asp Lys Asn Asp  Pro Ile Ser 
    1580                 1585                 1590             


Pro Tyr  Thr Gly Trp Leu Leu  Thr Ile Thr Glu Thr  Lys Gln Pro 
    1595                 1600                 1605             


Gln Pro  Leu Pro Met Pro Cys  Thr Gly Gly Cys Trp  Ala Pro Leu 
    1610                 1615                 1620             


Val Asp  Tyr Leu Pro Glu Thr  Ile Thr Pro Arg Gly  Pro Leu His 
    1625                 1630                 1635             


Arg Cys  Asn Ile Ala Val Ile  Phe Met Thr Glu Met  Val Val Asp 
    1640                 1645                 1650             


His Ser  Val Arg Glu Asp Trp  Ala Leu His Leu Pro  Leu Leu Leu 
    1655                 1660                 1665             


His Ala  Val Phe Leu Gly Leu  Asp His Tyr Arg Pro  Glu Val Phe 
    1670                 1675                 1680             


Glu His  Ser Lys Lys Leu Leu  Leu His Leu Leu Ile  Ala Leu Ser 
    1685                 1690                 1695             


Cys Asn  Ser Asn Phe His Ser  Ile Ala Ser Val Leu  Leu Gln Thr 
    1700                 1705                 1710             


Arg Glu  Met Gly Glu Ala Lys  Thr Leu Thr Val Gln  Pro Ala Tyr 
    1715                 1720                 1725             


Gln Pro  Glu Tyr Leu Tyr Thr  Gly Gly Phe Asp Phe  Leu Arg Glu 
    1730                 1735                 1740             


Asp Gln  Ser Ser Pro Val Pro  Asp Ser Gly Leu Ser  Ser Ser Ser 
    1745                 1750                 1755             


Thr Ser  Ser Ser Ile Ser Leu  Gly Gly Ser Ser Gly  Asn Leu Pro 
    1760                 1765                 1770             


Gln Met  Thr Gln Glu Val Glu  Asp Val Asp Thr Ala  Ala Glu Thr 
    1775                 1780                 1785             


Asp Glu  Lys Ala Asn Lys Leu  Ile Glu Phe Leu Thr  Thr Arg Ala 
    1790                 1795                 1800             


Phe Gly  Pro Leu Trp Cys His  Glu Asp Ile Thr Pro  Lys Asn Gln 
    1805                 1810                 1815             


Asn Ser  Lys Ser Ala Glu Gln  Leu Thr Asn Phe Leu  Arg His Val 
    1820                 1825                 1830             


Val Ser  Val Phe Lys Asp Ser  Lys Ser Gly Phe His  Leu Glu His 
    1835                 1840                 1845             


Gln Leu  Ser Glu Val Ala Leu  Gln Thr Ala Leu Ala  Ser Ser Ser 
    1850                 1855                 1860             


Arg His  Tyr Ala Gly Arg Ser  Phe Gln Ile Phe Arg  Ala Leu Lys 
    1865                 1870                 1875             


Gln Pro  Leu Ser Ala His Ala  Leu Ser Asp Leu Leu  Ser Arg Leu 
    1880                 1885                 1890             


Val Glu  Val Ile Gly Glu His  Gly Asp Glu Ile Gln  Gly Tyr Val 
    1895                 1900                 1905             


Met Glu  Ala Leu Leu Thr Leu  Glu Ala Ala Val Asp  Asn Leu Ser 
    1910                 1915                 1920             


Asp Cys  Leu Lys Asn Ser Asp  Leu Leu Thr Val Leu  Ser Arg Ser 
    1925                 1930                 1935             


Ser Ser  Pro Asp Leu Ser Ser  Ser Ser Lys Leu Thr  Ala Ser Arg 
    1940                 1945                 1950             


Lys Ser  Thr Gly Gln Leu Asn  Met Asn Pro Gly Thr  Thr Ser Gly 
    1955                 1960                 1965             


Asn Thr  Ala Thr Ala Glu Arg  Ser Arg His Gln Arg  Ser Phe Ser 
    1970                 1975                 1980             


Val Pro  Lys Lys Phe Gly Val  Ile Asp Arg Ser Ser  Asp Pro Pro 
    1985                 1990                 1995             


Arg Ser  Ala Thr Leu Asp Arg  Ile Gln Ala Cys Thr  Gln Gln Gly 
    2000                 2005                 2010             


Leu Ser  Ser Lys Thr Arg Ser  Ser Ser Ser Leu Lys  Asp Ser Leu 
    2015                 2020                 2025             


Thr Asp  Pro Ser His Ile Asn  His Pro Thr Asn Leu  Leu Ala Thr 
    2030                 2035                 2040             


Ile Phe  Trp Val Thr Val Ala  Leu Met Glu Ser Asp  Phe Glu Phe 
    2045                 2050                 2055             


Glu Tyr  Leu Met Ala Leu Arg  Leu Leu Ser Arg Leu  Leu Ala His 
    2060                 2065                 2070             


Met Pro  Leu Asp Lys Ala Glu  Asn Arg Glu Lys Leu  Glu Lys Leu 
    2075                 2080                 2085             


Gln Ala  Gln Leu Lys Trp Ala  Asp Phe Ser Gly Leu  Gln Gln Leu 
    2090                 2095                 2100             


Leu Leu  Lys Gly Phe Thr Ser  Leu Thr Thr Thr Asp  Leu Thr Leu 
    2105                 2110                 2115             


Gln Leu  Phe Ser Leu Leu Thr  Pro Val Ser Lys Ile  Ser Met Val 
    2120                 2125                 2130             


Asp Ala  Ser His Ala Ile Gly  Phe Pro Leu Asn Val  Leu Cys Leu 
    2135                 2140                 2145             


Leu Pro  Gln Leu Ile Gln His  Phe Glu Asn Pro Asn  Gln Phe Cys 
    2150                 2155                 2160             


Lys Asp  Ile Ala Glu Arg Ile  Ala Gln Val Cys Leu  Glu Glu Lys 
    2165                 2170                 2175             


Asn Pro  Lys Leu Ser Asn Leu  Ala His Val Met Thr  Leu Tyr Lys 
    2180                 2185                 2190             


Thr His  Ser Tyr Thr Arg Asp  Cys Ala Thr Trp Val  Asn Val Val 
    2195                 2200                 2205             


Cys Arg  Tyr Leu His Glu Ala  Tyr Ala Asp Ile Thr  Leu Asn Met 
    2210                 2215                 2220             


Val Thr  Tyr Leu Ala Glu Leu  Leu Glu Lys Gly Leu  Pro Ser Val 
    2225                 2230                 2235             


Gln Gln  Pro Leu Leu Gln Val  Ile Tyr Ser Leu Leu  Ser Tyr Met 
    2240                 2245                 2250             


Asp Leu  Ser Val Val Pro Val  Lys Gln Phe Asn Val  Glu Val Leu 
    2255                 2260                 2265             


Lys Thr  Ile Glu Lys Tyr Val  Gln Ser Val His Trp  Arg Glu Ala 
    2270                 2275                 2280             


Leu Asn  Ile Leu Lys Leu Val  Val Ser Arg Ser Ala  Ser Leu Val 
    2285                 2290                 2295             


Leu Pro  Ser Tyr Gln His Ser  Asp Leu Ser Lys Ile  Glu Ile His 
    2300                 2305                 2310             


Arg Val  Trp Thr Ser Ala Ser  Lys Glu Leu Pro Gly  Lys Thr Leu 
    2315                 2320                 2325             


Asp Phe  His Phe Asp Ile Ser  Glu Thr Pro Ile Ile  Gly Arg Arg 
    2330                 2335                 2340             


Tyr Asp  Glu Leu Gln Asn Ser  Ser Gly Arg Asp Gly  Lys Pro Arg 
    2345                 2350                 2355             


Ala Met  Ala Val Thr Arg Ser  Thr Ser Ser Thr Ser  Ser Gly Ser 
    2360                 2365                 2370             


Asn Ser  Asn Val Leu Val Pro  Val Ser Trp Lys Arg  Pro Gln Tyr 
    2375                 2380                 2385             


Ser Gln  Lys Arg Thr Lys Glu  Lys Leu Val His Val  Leu Ser Leu 
    2390                 2395                 2400             


Cys Gly  Gln Glu Val Gly Leu  Ser Lys Asn Pro Ser  Val Ile Phe 
    2405                 2410                 2415             


Ser Ser  Cys Gly Asp Leu Asp  Leu Leu Glu His Gln  Thr Ser Leu 
    2420                 2425                 2430             


Val Ser  Ser Glu Asp Gly Ala  Arg Glu Gln Glu Asn  Met Asp Asp 
    2435                 2440                 2445             


Thr Asn  Ser Glu Gln Gln Phe  Arg Val Phe Arg Asp  Phe Asp Phe 
    2450                 2455                 2460             


Leu Asp  Val Glu Leu Glu Asp  Gly Glu Gly Glu Ser  Met Asp Asn 
    2465                 2470                 2475             


Phe Asn  Trp Gly Val Arg Arg  Arg Ser Leu Asp Ser  Leu Asp Lys 
    2480                 2485                 2490             


Cys Asp  Met Gln Ile Leu Glu  Glu Arg Gln Leu Ser  Gly Ser Thr 
    2495                 2500                 2505             


Pro Ser  Leu Asn Lys Met His  His Glu Asp Ser Asp  Glu Ser Ser 
    2510                 2515                 2520             


Glu Glu  Glu Asp Leu Thr Ala  Ser Gln Ile Leu Glu  His Ser Asp 
    2525                 2530                 2535             


Leu Ile  Met Thr Leu Ser Pro  Ser Glu Glu Thr Asn  Pro Met Glu 
    2540                 2545                 2550             


Leu Leu  Thr Thr Ala Cys Asp  Ser Thr Pro Ala Glu  Pro His Ser 
    2555                 2560                 2565             


Phe Asn  Thr Arg Met Ser Ser  Phe Asp Ala Ser Leu  Pro Asp Met 
    2570                 2575                 2580             


Asn Asn  Leu Gln Ile Ser Glu  Gly Ser Lys Ala Glu  Ala Val Arg 
    2585                 2590                 2595             


Glu Glu  Glu Asp Thr Thr Val  His Glu Asp Asp Leu  Ser Ser Ser 
    2600                 2605                 2610             


Ile Asn  Glu Leu Pro Ala Ala  Phe Glu Cys Ser Asp  Ser Phe Ser 
    2615                 2620                 2625             


Leu Asp  Met Thr Glu Gly Glu  Glu Lys Gly Asn Arg  Ala Leu Asp 
    2630                 2635                 2640             


Gln Phe  Thr Leu Ala Ser Phe  Gly Glu Gly Asp Arg  Gly Val Ser 
    2645                 2650                 2655             


Pro Pro  Pro Ser Pro Phe Phe  Ser Ala Ile Leu Ala  Ala Phe Gln 
    2660                 2665                 2670             


Pro Ala  Ala Cys Asp Asp Ala  Glu Glu Ala Trp Arg  Ser His Ile 
    2675                 2680                 2685             


Asn Gln  Leu Met Cys Asp Ser  Asp Gly Ser Cys Ala  Val Tyr Thr 
    2690                 2695                 2700             


Phe His  Val Phe Ser Ser Leu  Phe Lys Asn Ile Gln  Lys Arg Phe 
    2705                 2710                 2715             


Cys Phe  Leu Thr Cys Asp Ala  Ala Ser Tyr Leu Gly  Asp Asn Leu 
    2720                 2725                 2730             


Arg Gly  Ile Gly Ser Lys Phe  Val Ser Ser Ser Gln  Met Leu Thr 
    2735                 2740                 2745             


Ser Cys  Ser Glu Cys Pro Thr  Leu Phe Val Asp Ala  Glu Thr Leu 
    2750                 2755                 2760             


Leu Ser  Cys Gly Leu Leu Asp  Lys Leu Lys Phe Ser  Val Leu Glu 
    2765                 2770                 2775             


Leu Gln  Glu Tyr Leu Asp Thr  Tyr Asn Asn Arg Lys  Glu Ala Thr 
    2780                 2785                 2790             


Leu Ser  Trp Leu Ala Asn Cys  Lys Ala Thr Phe Ala  Gly Gly Ser 
    2795                 2800                 2805             


Arg Asp  Gly Val Ile Thr Cys  Gln Pro Gly Asp Ser  Glu Glu Lys 
    2810                 2815                 2820             


Gln Leu  Glu Leu Cys Gln Arg  Leu Tyr Lys Leu His  Phe Gln Leu 
    2825                 2830                 2835             


Leu Leu  Leu Phe Gln Ser Tyr  Cys Lys Leu Ile Gly  Gln Val His 
    2840                 2845                 2850             


Glu Val  Ser Ser Met Pro Glu  Leu Leu Asn Met Ser  Arg Glu Leu 
    2855                 2860                 2865             


Ser Asp  Leu Lys Lys His Leu  Lys Glu Ala Ser Ala  Val Ile Ala 
    2870                 2875                 2880             


Ala Asp  Pro Leu Tyr Ser Asp  Gly Ala Trp Ser Glu  Pro Thr Phe 
    2885                 2890                 2895             


Thr Ser  Thr Glu Ala Ala Ile  Gln Ser Met Leu Glu  Cys Leu Lys 
    2900                 2905                 2910             


Asn Asn  Glu Leu Gly Lys Ala  Leu Arg Gln Ile Arg  Glu Cys Arg 
    2915                 2920                 2925             


Ser Leu  Trp Pro Asn Asp Ile  Phe Gly Ser Ser Ser  Asp Asp Glu 
    2930                 2935                 2940             


Val Gln  Thr Leu Leu Asn Ile  Tyr Phe Arg His Gln  Thr Leu Gly 
    2945                 2950                 2955             


Gln Thr  Gly Thr Tyr Ala Leu  Val Gly Ser Asn Gln  Ser Leu Thr 
    2960                 2965                 2970             


Glu Ile  Cys Thr Lys Leu Met  Glu Leu Asn Met Glu  Ile Arg Asp 
    2975                 2980                 2985             


Met Ile  Arg Arg Ala Gln Ser  Tyr Arg Val Leu Thr  Thr Phe Leu 
    2990                 2995                 3000             


Pro Asp  Ser Ser Val Ser Gly  Thr Ser Leu 
    3005                 3010             


<210>  3
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  3

Trp Gly Val Arg Arg Arg Ser Leu Asp Ser Leu Asp Lys Cys 
1               5                   10                  


