                               SEQUENCE LISTING	

<110> CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> METHOD FOR DIAGNOSIS AND METHOD OF TREATMENT OF AUTISM SPECTRUM 
      DISORDERS AND INTELLECTUAL DISABILITY

<130> 701039-069201-PCT

<140>
<141>

<150> 61/419,908
<151> 2010-12-06

<160> 20    

<170> PatentIn version 3.5

<210> 1
<211> 481
<212> DNA
<213> Homo sapiens

<400> 1
atggcccgaa ccaagcagac tgcgcgcaag tcaacgggtg gcaaggcgcc gcgcaagcag       60

ctggccacca aggtggctcg caagagcgca cctgccactg gcggcgtgaa gaagccgcac      120

cgctaccggc ccggcacggt ggcgcttcgc gagatccgcc gctaccagaa gtccactgag      180

ctgctaatcc gcaagttgcc cttccagcgg ctgatgcgcg agatcgctca ggactttaag      240

accgacctgc gcttccagag ctcggccgtg atggcgctgc aggaggcgtg cgagtcttac      300

ctggtggggc tgtttgagga caccaacctg tgtgtcatcc atgccaaacg ggtcaccatc      360

atgcctaagg acatccagct ggcacgccgt atccgcgggg agcgggccta ggagggctat      420

ctcgccacct gagaggttgc gcaacgttca ccccaaaggc tcttttaaga gccacccacc      480

t                                                                      481


<210> 2
<211> 136
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Val Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Met Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ser Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Val 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210> 3
<211> 1499
<212> DNA
<213> Homo sapiens

<400> 3
acttccgtcc ggtctgcctg gtctctctaa ccgcgccagt gtgcctccga ctcggaacgg       60

cttccgcggc cggggcagcg agggccgggg gcggcgggcg ggatgagtgc ggtgtgcggt      120

ggagcggcgc ggatgctgcg gacgccggga cgccacggct acgccgccga gttctccccg      180

tacctgccgg gccgcctggc ctgcgccacc gcgcagcact acggcatcgc gggctgtgga      240

accctactaa tattggatcc agatgaagct gggctaaggc tttttagaag ctttgactgg      300

aatgatggtt tgtttgatgt gacttggagt gagaacaacg aacatgtcct catcacctgt      360

agtggcgatg gctcgctgca gctctgggac actgccaaag ctgcagggcc actgcaagtc      420

tataaagaac acgctcagga ggtgtatagt gttgattgga gccaaaccag aggtgaacag      480

cttgtggtgt ctggctcatg ggatcaaact gtcaaattgt gggatccaac tgttggaaag      540

tctctgtgca cctttagagg ccatgaaagt attatttata gcacaatctg gtctccccac      600

atccctggtt gttttgcttc agcctcaggt gatcagactc tgagaatatg ggatgtgaag      660

gcagcaggag taagaatcgt gattcctgca catcaggcag aaatcttgag ttgtgactgg      720

tgtaaataca atgagaattt gctggtgacc ggggcggttg actgtagttt gagaggctgg      780

gacttaagga atgtacgaca accagtgttt gaacttcttg gtcataccta tgctattagg      840

agggtgaaat tttcaccatt tcatgcttct gtgctggcct cttgctcgta tgattttact      900

gtaagattct ggaacttttc aaagcctgac tctcttcttg aaacagtgga gcatcataca      960

gagtttactt gtggtttaga cttcagtctt cagagcccca ctcaggtggc tgactgttct     1020

tgggatgaaa caataaagat ctatgaccct gcttgtctta ctattcctgc ttgagataca     1080

ctactttggt cagaaacaga ggatgttggc tgaagaactg cctaacagca aataaattaa     1140

ctatggaaaa catagacatt atgcttttat atgctattca gatttcaaat ctttccaatt     1200

taccctggaa tcagttttga gggagctgat aaagacttta gctgactcgt taagcctgat     1260

acataagcca tatttaaaat tctaagaaat aattaatgtt atgatatatc ttgtagtatc     1320

tattaaaatg tctctgggtc ataaaatgga ttaaaatatg ggagatcagt aggttatact     1380

tatatagata gtgatatatt tcatttttaa tttgtcattt ttgatgtaaa atataatcac     1440

tgctgtgata aataaactat ctattgatca tttatcattt taaaaaaaaa aaaaaaaaa      1499


<210> 4
<211> 323
<212> PRT
<213> Homo sapiens

<400> 4
Met Ser Ala Val Cys Gly Gly Ala Ala Arg Met Leu Arg Thr Pro Gly 
1               5                   10                  15      


Arg His Gly Tyr Ala Ala Glu Phe Ser Pro Tyr Leu Pro Gly Arg Leu 
            20                  25                  30          


Ala Cys Ala Thr Ala Gln His Tyr Gly Ile Ala Gly Cys Gly Thr Leu 
        35                  40                  45              


Leu Ile Leu Asp Pro Asp Glu Ala Gly Leu Arg Leu Phe Arg Ser Phe 
    50                  55                  60                  


Asp Trp Asn Asp Gly Leu Phe Asp Val Thr Trp Ser Glu Asn Asn Glu 
65                  70                  75                  80  


His Val Leu Ile Thr Cys Ser Gly Asp Gly Ser Leu Gln Leu Trp Asp 
                85                  90                  95      


Thr Ala Lys Ala Ala Gly Pro Leu Gln Val Tyr Lys Glu His Ala Gln 
            100                 105                 110         


Glu Val Tyr Ser Val Asp Trp Ser Gln Thr Arg Gly Glu Gln Leu Val 
        115                 120                 125             


Val Ser Gly Ser Trp Asp Gln Thr Val Lys Leu Trp Asp Pro Thr Val 
    130                 135                 140                 


Gly Lys Ser Leu Cys Thr Phe Arg Gly His Glu Ser Ile Ile Tyr Ser 
145                 150                 155                 160 


Thr Ile Trp Ser Pro His Ile Pro Gly Cys Phe Ala Ser Ala Ser Gly 
                165                 170                 175     


Asp Gln Thr Leu Arg Ile Trp Asp Val Lys Ala Ala Gly Val Arg Ile 
            180                 185                 190         


Val Ile Pro Ala His Gln Ala Glu Ile Leu Ser Cys Asp Trp Cys Lys 
        195                 200                 205             


Tyr Asn Glu Asn Leu Leu Val Thr Gly Ala Val Asp Cys Ser Leu Arg 
    210                 215                 220                 


Gly Trp Asp Leu Arg Asn Val Arg Gln Pro Val Phe Glu Leu Leu Gly 
225                 230                 235                 240 


His Thr Tyr Ala Ile Arg Arg Val Lys Phe Ser Pro Phe His Ala Ser 
                245                 250                 255     


Val Leu Ala Ser Cys Ser Tyr Asp Phe Thr Val Arg Phe Trp Asn Phe 
            260                 265                 270         


Ser Lys Pro Asp Ser Leu Leu Glu Thr Val Glu His His Thr Glu Phe 
        275                 280                 285             


Thr Cys Gly Leu Asp Phe Ser Leu Gln Ser Pro Thr Gln Val Ala Asp 
    290                 295                 300                 


Cys Ser Trp Asp Glu Thr Ile Lys Ile Tyr Asp Pro Ala Cys Leu Thr 
305                 310                 315                 320 


Ile Pro Ala 
            


<210> 5
<211> 323
<212> PRT
<213> Homo sapiens

<400> 5
Met Ser Ala Val Cys Gly Gly Ala Ala Arg Met Leu Arg Thr Pro Gly 
1               5                   10                  15      


Arg His Gly Tyr Ala Ala Glu Phe Ser Pro Tyr Leu Pro Gly Arg Leu 
            20                  25                  30          


Ala Cys Ala Thr Ala Gln His Tyr Gly Ile Ala Gly Cys Gly Thr Leu 
        35                  40                  45              


Leu Ile Leu Asp Pro Asp Glu Ala Gly Leu Arg Leu Phe Arg Ser Phe 
    50                  55                  60                  


Asp Trp Asn Asp Gly Leu Phe Asp Val Thr Cys Ser Glu Asn Asn Glu 
65                  70                  75                  80  


His Val Leu Ile Thr Cys Ser Gly Asp Gly Ser Leu Gln Leu Trp Asp 
                85                  90                  95      


Thr Ala Lys Ala Ala Gly Pro Leu Gln Val Tyr Lys Glu His Ala Gln 
            100                 105                 110         


Glu Val Tyr Ser Val Asp Trp Ser Gln Thr Arg Gly Glu Gln Leu Val 
        115                 120                 125             


Val Ser Gly Ser Trp Asp Gln Thr Val Lys Leu Trp Asp Pro Thr Val 
    130                 135                 140                 


Gly Lys Ser Leu Cys Thr Phe Arg Gly His Glu Ser Ile Ile Tyr Ser 
145                 150                 155                 160 


Thr Ile Trp Ser Pro His Ile Pro Gly Cys Phe Ala Ser Ala Ser Gly 
                165                 170                 175     


Asp Gln Thr Leu Arg Ile Trp Asp Val Lys Ala Ala Gly Val Arg Ile 
            180                 185                 190         


Val Ile Pro Ala His Gln Ala Glu Ile Leu Ser Cys Asp Trp Cys Lys 
        195                 200                 205             


Tyr Asn Glu Asn Leu Leu Val Thr Gly Ala Val Asp Cys Ser Leu Arg 
    210                 215                 220                 


Gly Trp Asp Leu Arg Asn Val Arg Gln Pro Val Phe Glu Leu Leu Gly 
225                 230                 235                 240 


His Thr Tyr Ala Ile Arg Arg Val Lys Phe Ser Pro Phe His Ala Ser 
                245                 250                 255     


Val Leu Ala Ser Cys Ser Tyr Asp Phe Thr Val Arg Phe Trp Asn Phe 
            260                 265                 270         


Ser Lys Pro Asp Ser Leu Leu Glu Thr Val Glu His His Thr Glu Phe 
        275                 280                 285             


Thr Cys Gly Leu Asp Phe Ser Leu Gln Ser Pro Thr Gln Val Ala Asp 
    290                 295                 300                 


Cys Ser Trp Asp Glu Thr Ile Lys Ile Tyr Asp Pro Ala Cys Leu Thr 
305                 310                 315                 320 


Ile Pro Ala 
            


<210> 6
<211> 136
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Val Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg His Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Met Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ser Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Val 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210> 7
<211> 136
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Val Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Met Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ser Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Val 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Cys Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210> 8
<211> 136
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Val Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Met Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ser Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Val 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Cys Ile Arg Gly Glu Arg Ala 
    130                 135     


<210> 9
<211> 12901
<212> DNA
<213> Homo sapiens

<400> 9
cattatctac atttcttttt tttttttttt ttttctgaga ggtagcctcg ttttgtcacc       60

caggctggag tacagtggct tgatcttggc tcactgcaac ctccacctcc tgggttcaag      120

caattctcct gcctcagcct cccgagtagc tgggattaca ggcatgcgcc accacgctca      180

gctaatattt ttgtattttt agtagagatt gggtttcact atgttggtca ggctggtctc      240

gaactcctga acttaaatga tccacccgcc ccagcctccc aaagtgctgg cattacagac      300

agatgtaagc cactgcaccc agcctacgtt ttctacatct cttttttttt ttttttgaga      360

ccgtgtcttg ctctgtcgcg cccaggctgg agtggaatgg cgcgatctca gctcactgca      420

agctccgcct cctgggttca cgccattctc ctgcctcagc ctcccgagta gctgggacta      480

caggtgcccg ccaccaagcc cggctaattt tttgtatttt tagtagagac ggggtttcac      540

tgtgttagcc aggatggtct caatctcctg accttgtgat ccgcccgcct cggcctccga      600

aagtgctggg attacaggct tgagccaccg tgcccggcca cgttttctac atttcttagt      660

ccacttggtg aactcttcct ccttcaggcc tcatatgtac attttctgcc tcttccaggg      720

ttagagcgct gctctctagc agcatcttgg acgtgtggca agatctgcag tcgtggtttg      780

tttccaggac ctactcattt agactgtgag cacctttagg aaggcagaat tgtctttggg      840

ccctagtgat acttgttgaa attgttagtt tagtagaaga gtacattgaa aggggaagag      900

gcaggtggat cacctaaggt caggaatttg agagcatcct ggccaacatg gtgaaattct      960

gtctctacta aaagtacaaa acaattagct gggcgtggtg gcacgtacct gtagtcccgg     1020

ctactaggga ggctgaggca ggagaatcgc ttgaacctgg gaggtggagg ttgcagtgag     1080

ctgagatcac gctactgcac tccagcctgg gcaaaagagc aagatttcct ctcaaaaaaa     1140

aaaaaaaaag aaaaggtggg gagaaggaag aggtggcacc tttgatcttt gagcttttca     1200

ggcccctggg cctgggtctg acttgttgta atgggttgta tgtgttctag ttgcaggaaa     1260

tcacgtttaa gaattactac acagcttttt tgagcatccg tgtccgtcag tacacctcag     1320

cacacacacc tgccaagtgg gtgacctgcc tgcgggacta ctgcctaatg cctgacccac     1380

acagtgagga gggagcccag gagtatgtat cgctgttcaa gcatcaggtc agctgggcct     1440

caggatggcc agggcagccc agatgaggac ttaccagagg tggggggatt ggatcaatat     1500

accaagaggg aagagggggc cagtctggcc tgaactgtga cttccaggga agtgccttgg     1560

agggactact gttccttcct tcccaaggcc tgtggggtgg gcagcattct ggctcattgc     1620

tggttgggag gcttctgggc agtgagctgg atccttgctg ggtccttgtg tgtgtgtgtc     1680

agatgctgtg tgacatggct agaatatcgg agctacgcct gattctgcgg cagccatcac     1740

cactgtggct gtctttcaca gtggaggagc tgcagatcta tcagcaggga ccaaaggtaa     1800

gtgactagct cagctgctgg ctggcccttt ccccagaaag cttctatgac tgggaaagct     1860

aggtggtggg gtgggtaatg ggtgaagatt gtgaatgggg ccttcatgga ggttagctgg     1920

gtgtgaatgc tggaagctca caatgagagg tgaggccatg tccccatatc ccctgacctt     1980

tggggccacc tgctactttc agagctggag cctttaggtg ctgggagaca cttttgagct     2040

tgtgtttctg aggactccgt ctgcacagca ggagaactta ggtagtctga ctgcctcttt     2100

aggtctctgt gggctcccta aacagggttt tcccagtgtc tgaggcccag cggcccttct     2160

ctctgctcct aggaccttgg aatctggtcc cagagctgtc cactttgtct cactcagggc     2220

agtacatctt tgctttgcag agcccctccg tgacctttcc caagtggctc tcccacccag     2280

tgccctgtga gcaacctgca ctcctccgtg aggtaagccc tcaccctagg taagaaccat     2340

gtgtgaatgg ctctagtgtc caacacaggc caggtagacc ccttcctgta aaattctggg     2400

gctgggccca gggcccttgg gtgttatctt cctcctgggt attctgtggg atttgaggca     2460

tctctgttgt ggggctacat caggccctaa cctcatgttt cataagccat ctgagaatgt     2520

tgttggtctc agctggaggg cccctagccc aggttggcct ctctggagcc tgaagggcac     2580

tgctggggag agacccatgg ccactgaccc ctccttctgg agcagggtct cccagacccc     2640

agcagggtat cctccgaggt gcagcagatg tgggcactga cagagatgat ccgggccagt     2700

cacacctccg caaggatcgg ccgctttgat gtaagtaatc gcttccttct gcttggcttg     2760

ctttgccctg agcagatcag acctgatggt cttttgtatt tcaggtggat ggctgttatg     2820

acctgaactt gctctcctac acttgaatgg ttgctcctag ccaagatgtt ggcctttctg     2880

tgcccaccca gacttggttt gggccaccag aggctgaagt gtatttcctg tgcattccaa     2940

gtgttgcctg catgcctgtt ctgtctgggc cacattcaca gattcaggat tctcaggggc     3000

ttaccgtgtt acttcagcat gagctcctgg catgggggtg ctctgtcttc gcctggctgc     3060

aactcaattc ttccttctac ccaaaaacac tccagtcagt tgtacttact gagaatccct     3120

gagtgccctc tgccccttct ggcaacatgc acattcctgt cttctgcctg ctccctcatg     3180

tcagtgcagt tgggctgggc tgacctacta aaacctgctc catgtatgga cctggaaggc     3240

cattgctgcc atggcacttg ggacacttga ggaagaaaca gaaaccttat ttcttcctgt     3300

gtgtccccta gtggttttct ttccatttgt gttatgccac agagagaaat ttcctgtctg     3360

aactcttctg ctgcctgcct aggaaggaaa cctgaagatt tgggcagcct gagtctcttg     3420

gtttctgagc tggctcctga atatatgttc aagtgggtgt gcccataggg cctgggcacg     3480

tgtctctagc aaaaccaggg cctgagcata agaactggga cccttctagg cagggtgcag     3540

tggctcacgc ctgtaatccc agcactttgg gaggcccagg caggcggatc acctgaggtc     3600

aggagttcaa gaccagcctg accaacctgg agaaaccccg tctctactaa aaatacaaaa     3660

aattagctgg gcgtggtggt aggcacctgt aatcccagct acttgggagg ctgaggcagg     3720

agaatctctt gaacccggga agtggaggtt gcggacctga gatcatgcca ttgcactcca     3780

gcctgggcaa gaagagcgaa actccatctt aaacaaacaa acaaaaaaaa aagaactggg     3840

acccttctgc catctgacat agcccaaagc acatctctat cctttctccc agttgcccct     3900

ctcctttttt gttgtttttt ttgaggttga gttttgctct tgttgcccag gctggagtgc     3960

aatagtgcaa tcttggctaa ctgcaacctc cgcctcccag gttcaagcaa ttctcctgcc     4020

tcagtctccc gagtagctgg gattacagtc atgcatcacc atgcctggct aattttgtat     4080

ttgtagtaga gatggggttt ctccatgttg gtcaggctgg tctcaaacac ctgacctcag     4140

gtgatctgcc tgccttggcc ttccaaagtg ctgggattac aggcatgagc caccgcgccc     4200

gccctgcccc tttccaagag atatgctcag cataatgaga gatcaaccgt ggtggggagt     4260

gggtccaagt aagggttctc attgttgcct tttaagaggc ctaagtcctg cattaactca     4320

gtccaaccat taagtgatgc aggctgctct tccctcatgt gagaaaaacc tgtttccctc     4380

tggttcttcc tggctttgca cctggtggct attacaaagc agtactgcag tatgtcttgg     4440

acctggaaag ttggacatgt gtgtggctca acagttttct cgggggagtt cagtgacctt     4500

ttggtggcca ccctctgttc tcacctgtga gttcttgcag gtggcgactt catctgcaag     4560

gtcacttaca tagccccact cagctgcttc ggaaagcgtg acgaagcagt agtcctcagt     4620

gtgtgtgtaa gtgaagagga ccttgtggta gcagggacca tgcttcattc gtggctgtgt     4680

ccccatctga gggcctggta tgcagtaaga tcaataaata cttgtggaat gcatgactgc     4740

tggctgcctg tgtctgcctg gtgggagagc tgtggaacta ggggtccaca tgaggacaga     4800

ctactgtggt gctgcctacc tgccaggctg gcccaccttc cccaccccca cttgacctta     4860

ctctcttgag gtcctaaagg tatgattcag acctttcagc cctttccaga actttgaccc     4920

tctggagaca gggcggttct gcagggggcg gtctagcccc tagctttgtt ctgggcagcc     4980

caatcagctc tggattgccc gagctgccct gaagagtcag ccgaaagagc tggaggcttc     5040

ttccctgtgg ttgcgggttc ctgcattctc tgctctaaat cccagcctgc ccttggggct     5100

gcccacgccc ccttcagatc ctttgctccg gagagagacc tgtccgagca gaggcctgga     5160

ctacatctcc cggcgtgcct ggcagtgtgg tggcctctgt gcgccgtctg cactcgttgc     5220

aggcgacgat gcagagggct gtaagtgtgg tggcccgtct gggctttcgc ctgcaggcat     5280

tccccccggc cttgtgtcgt ccacttagtt gcgcacaggt gggatagagg gtgctgatct     5340

tggagggtgg gggagggaag cggctggggg ctagggccct ggtggcacta agcccagccg     5400

cccacaggag gtgctccgca ggacaccgct ctatgacttc cacctggccc acggcgggaa     5460

aatggtggcg tttgcgggtt ggagtctgcc agtgcagtac cgggacagtc acactgactc     5520

gcacctgcac acacgccagc actgctcgct ctttgacgtg tctcatatgc tgcaggtgag     5580

ccaggggagc acactggcca tctgatcagg ccttcctccc tgtttacagt ggtccactcc     5640

ttggctttgt ttgctgtgaa ctggattcca aggacagcct tctcagaaga gctagaggtc     5700

atgggggtgt catggatagg tcaatggccc caaggaaatg agctcagagg gtctcatcat     5760

ctcatccttc tagcttgccc ccattaaatg gtgtgcctta atgtcccggg ttttccaggg     5820

ctgacaccca ctctcatgta ttgggctgga tgttggtttg aaaaggggtt atttcaggaa     5880

ggtgctaggt cctgtccagt tccctggcag tccccccaca cagagtgact gggggaggtc     5940

aggaaatcag aaggtggtcc tttgccacgt gtagaaccaa aagactggtt agtcactttg     6000

ggtgggctgg actgcactgt ggatggcagg gaggatgcat ccttgcttag tagccttttg     6060

gattgtagct gttgcaatgg cctgaggctt tcaatctctt ccccagacca agatacttgg     6120

tagtgaccgg gtgaagctga tggagagtct agtggttgga gacattgcag agctaagacc     6180

aaaccaggtg ggccctttta tttctgctct atgagttttc ttagtcatga gccagcaaat     6240

gggctgagtc cctacctcag gcttaggggc acagagatga gtcaaacaca gcttctcagg     6300

gcttgcagtc ttggacagaa tccctgagtc atttccagag acacagacat ttgtagggag     6360

gggaatatcc cagtcttact acatcaggct aggaggccag aaaccaaggt taatatgctg     6420

ctctctggcc atcccttctg cttaacccct ctctattcaa catgtggtcc ctggccaggc     6480

gacgtgactc aaacacctgt aatcctggca cttggggagg ccaaggcggg tggatcacct     6540

gaggtcagga gttcgagacc agcctggcca acatggcaaa acctcgtttc tactaaaaac     6600

acaaaaatta gccgggcgtg gtggcgcgtg cttgtagtcc cagctactcg ggaggctgag     6660

gttgcagcaa gctgaggttg caccactgca ctctggcctg ggcaacagag tgagactcag     6720

tctaaaaaga aaaataacaa caacaaagtg tggtctctaa accagcatct ttggagcttg     6780

ttaggaatat agtctcaggc actgctgcag acctgctgaa tcagaacctt cattttaaca     6840

agatccccag gtgattcatg tgaccccctc aacctcaggc tttttgtcca tccagtgggg     6900

aggctaagga agttttttgg gggcattgct atggagtact taggagagcc tgcgatcatc     6960

aagatgacct ttgaagcttt tgtcctgtgg gttgccacat gggctaagtc gtcccaggtt     7020

tgggtaggtg aagcagcagg tcctaggtgt catagattaa gtgtcagatg ggactctcag     7080

tacagagtgg ggaggggtgc agaggttgca ccagatcagg gaagcacccc aaggtaggga     7140

ggggatgaaa acttacttga tgcatgagga tcaaagacct tggacttggg cccagacttg     7200

taccttgcac accctgagtc cttcacatta gggttcataa ccttttggta actaagtggg     7260

tccagggttg tgtctggctc acccttggcc ttgccctcct ggacctggaa gccaaaacgc     7320

tccactttgg tcctagggga cactgtcgct gtttaccaac gaggctggag gcatcttaga     7380

tgacttgatt gtaaccaata cttctgaggg ccacctgtat gtggtgtcca acgctggctg     7440

ctgggagaaa gatttggccc tcatgcaggt ataccccctc tgtgttctag acaccttgtc     7500

ttccttgttc atagagcagt atccttgttg tccaagacag ggttggcaca gacaagggac     7560

ctggaaaatg gctctttcag tgaatgaaca gctatgagac tcaagagcag gccctctctg     7620

gagcacgcca gggtttggtg gtgggggatt accaggcatg gggagggggt cttggcccct     7680

ctggtgtgag gtggcagaac tgggcttggg tcatctctat cacttagtag ctatgtgacc     7740

ttgtaagatg ggaaccagcc tactaccttt ttttttcctc cctcctcctc ctcctctcca     7800

ctgtcctact actgtccagc tctgcagcgt ccagcccatg gtagctgctc agtaagtggc     7860

cccagatgct cttgtgtttc tgtcttttag gacaaggtca gggagcttca gaaccagggc     7920

agagatgtgg gcctggaggt gttggataat gccctgctag ctctgcaagg tgagagggct     7980

gggctggggt tggagccaac ctttgccttc ctggcttcat tgactgctta gcacagaggc     8040

cataccaaga agaatgtgtg gaaggtgtga tatttgtgtg ccataatttt aagttttgta     8100

tcttgccctc ctcctaccta ccacaaggct ccatgggcta gggacaaggg catcttctcc     8160

cacttgcaga gtaagacatg ctcagggctt gttctggtcc ctgaataagg ctttagtcca     8220

gctttgaggg atgctgggac ctggatactt ggtcactggc tccctgggcc caggccccac     8280

tgcagcccag gtactacagg ccggcgtggc agatgacctg aggaaactgc ccttcatgac     8340

cagtgctgtg atggaggtgt ttggcgtgtc tggctgccgc gtgacccgct gtggctacac     8400

aggagaggat ggtgtggagg tgtgtcaaga agtggtgtgg gggcagtaca gggcacagga     8460

tgcatgtgag gggttggggg tatgtggtac agggagcttc ccatctgccc tctggtgttt     8520

catacagatc tcggtgccgg tagcgggggc agttcacctg gcaacagcta ttctgaaaaa     8580

cccagaggtg aagctggcag ggctggcagc cagggacagc ctgcgcctgg aggcaggcct     8640

ctgcctgtat gggaatgaca ttgatgaaca cactacacct gtggagggca gcctcagttg     8700

gacactgggt gagctgggcc agcactaaag gatagggtcc tggaggtcag ggtgaccctt     8760

gataagacta gccagcccat gactcatcca aaggttatgt agcctgaagc cttcctgagc     8820

ctcccttccc tgaaggtgcc actgtgcctt tgcccattag aaactgcaga tgttggccgg     8880

atgcggtggc tcacatctgt aatcccagca ctttgggagg ccgaggcggg tggatcacga     8940

ggtcaggaga tcaagaccat cctggctaac atggtgaaac cccgtctcta ctaaaaatac     9000

aaaaaaaaaa ttagctgggc attgtggcgg gcgcctgtag tcccagctac tcgggaggct     9060

gaggcaggag aatggcatga acctgggcgg cggagtttgc agtgagccga gattgcgcca     9120

ctgcacctcc agccagggcg atagagcgag accccgtctc aaaaaaaaaa aaaaaaaaaa     9180

aaaagaaact gaagatgctg ccgggcatgg tggctcacac ctgtaatccc agcactttgg     9240

gaggccaagg tgggtggatc atgaggtcag gaattcgaga atagcctggc caacatggtg     9300

agaccccgtc tctactgaaa atataaaaat tagccaggcg tggtggcggg tgcctgttat     9360

cccagctact cgggagactg aggcaggtaa attgcttgaa cctgggaggc agagtttgca     9420

gtgagctgag atcgtgccac tgcattctag gcctgggcga cagagtgact ccatctcaaa     9480

aaaaaaaaaa agaaactgaa gacgctcggc aggtgggcag catggcctcc aggggatagg     9540

aggtggttgg ttggctgacg gcagtgaagg gaggaataga gcctggagta gcccaagcaa     9600

aggggccttg atgctagata gtgtgttact tgaggacctc ataaggacct cctgtggcca     9660

gggcttctat gggctgtggc ttatgtctca tgtgtcattc tccagggaag cgccgccgag     9720

ctgctatgga cttccctgga gccaaggtca ttgttcccca gctgaagggc agggtgcagc     9780

ggaggcgtgt ggggttgatg tgtgaggggg cccccatgcg ggcacacagt cccatcctga     9840

acatggaggg taccaagatt ggtaggtgga ccagggaagc tgggaaaccc ttgtctcttc     9900

ccaggagggt gggggcactg gcagggtggt gctgatgcgt ggcttatgct tgcttgacag     9960

gtactgtgac tagtggctgc ccctccccct ctctgaagaa gaatgtggcg atgggttatg    10020

tgccctgcga gtacagtcgt ccagggacaa tgctgctggt agaggtgcgg cggaagcagc    10080

agatggctgt agtcagcaag atgccctttg tgcccacaaa ctactatacc ctcaagtgaa    10140

gctggctcag ggtggggctg tcccttccag gagttttgcc cctacaaggg gttagtcaag    10200

aagctgaggc agaactcact gggggtgggc agttaaggtg gaggctgatt ctaattgtct    10260

ggttgagggg ccacaccacc tattcccccc acctaactca tgccattcca gcttccttca    10320

ggaccctgct tctgagtgac ggaccagctc acacaatgtc ttgtttcagt ccatgatccc    10380

actgacctac tcttgcctgc tggagggtaa tgagaagctt tggttctgcc atctctccca    10440

ctctgccagg tgctggctgt ggagcaaagg ctcacctttg tggagaggat aaaacctgcc    10500

caacctacct caccatggtt tttcacattg caaagggtaa taacatgggc agtgcggact    10560

taggctaccc cctccagttt gctttccgta aatgcaaatt gtccttactg caagtcagga    10620

atgattgctg actcacagta gggctgctat gcctgtgtgt aaacttgggg atggctgagg    10680

gaacatagac tcactcttcc acattcccaa gttggtctag tgtgctgccc agtagcaaac    10740

catggcagac tcaccaccta ttctgagttc cagggctgct gtagggcagg gtgggcttcc    10800

tcccagactt gccttaccct gggctgatct ttgcccctgg tatgcattaa tggactccac    10860

tgaatcctga aaaaaaaatt aaacttcctt cttacttgcc agtctctagc ttcattgttc    10920

tctgttcaca gggttcctga aatgccaacc caatgcctgc cttcctggcc tccaagacaa    10980

gcttggaata ggttctcctt gaaaggggcc agtctataaa aatggagata ttgcccctgt    11040

tgggcacccc atccctgctc ctccagggag ctgcatcacc tctcccctcc ctgcaagtta    11100

ttgcatctgg gtcccaaggg gcaacagctt ccaggatgtt ccctctctca ctgcccctgt    11160

gcatgcacac ccttgttctg tctgaataac cacaacaacc gatgcacttc cgtgtttaat    11220

aagccacatc ctcagttgag cctggggtga aatgtgagat cctgactctg tgcagtagta    11280

ttagtgggtg ggccaggggc tgtgaataac atcatcctca gtacagctgc aattccaggg    11340

cccctctacc acaaagatgg cttaagcaaa ggcagccaga tggaagtatg atatccaaca    11400

ggaaggaagt aggcaggggt cactaaagtg gctggtggcc cagcagatgg aaacagaagt    11460

atggccccga gggaaggagg caggtccagg gctacagtgc tttcaggtac tggtgtttct    11520

ataggggcat ttgccaccca catctttgga aactcccctg gcctattgtg acatggcagg    11580

gctgcctggt tcttgaaggt agagaaaatg ctagtgggga ggagctgagc ctgtgacgtg    11640

catttgtacc aggtccagat gggaaatgat gaggctgcag gctatgatgg ggccactgtg    11700

cactaaatgc ttggtaccat cctatgaggg gacaaggtgc agacccacat tcccataggc    11760

acttaagcag tggtggatag gaggctaccc caggggttca gctgtccttc aggtaatcag    11820

cttaccccca agaaggactg agaggaatat gagtaggaca gttggcagat gacaatttcc    11880

tttgcctggc tcacgggaga agtctggttg ggccaggtat gtgggtgttt ggtgcctcca    11940

tctggatagt gccagcaggt acaccaccct gccttatacc tgaatggcca gctaaataac    12000

catagagctt aaggtctggc tcaggtcagg attccctggc tccttgccaa caaagcaaaa    12060

ccagagattc agaaaactca gggcctagga gaaaacagac ctgccttaca aaccccagag    12120

ctggtcaacc tcaggcttcc tctcaggaaa aaaatttttt ttttgagatg ggtcttgctc    12180

tgttgcccag gctggagtac aacggcgcaa tcttggctca ctgcaacctc tgcctcccag    12240

gttcaagcaa atctcctgct tcagcctcct gagtagctgg gattactggt gtgtgccacc    12300

acacccggct aatttttgta tttttagtag agatggggtt ttcaccatgt tggtcaggct    12360

ggtctcgaac tcctgacctc gtgatctgcc tgcctcagcc tcccaaagtg ttgggattac    12420

aggcgtgagc caccatgcct ggccaactca ggaaaaattt ttatggggtc acatcttggg    12480

gatggaagag ggacaggaaa agaaacctaa gacaaaagaa ctgatggtct tcccaaccca    12540

gaggcttcct gagttatcac ccctgagaga ggaagaacac aatctctctc cttaaggcac    12600

ccagataaga gtacaggcaa actcttcact tgcccagtgc ctgggtgagg gagcaggctt    12660

aagaggcaga agaggcccag ccctgtaggc actgggtact ccctgctacc aaccctgaac    12720

ccccggcagt tgtccctgag gtctggggag tagcagaacc cagtgtagaa gccagcagac    12780

ccagtgatgc ccttggagac cctctgctgc cttcccttat tctctgtggg ttttgagagg    12840

ttcgtttgct gccatttccc tgaaagtgat ggagagagag aagagagagt ggttattcca    12900

t                                                                    12901


<210> 10
<211> 403
<212> PRT
<213> Homo sapiens

<400> 10
Met Gln Arg Ala Val Ser Val Val Ala Arg Leu Gly Phe Arg Leu Gln 
1               5                   10                  15      


Ala Phe Pro Pro Ala Leu Cys Arg Pro Leu Ser Cys Ala Gln Glu Val 
            20                  25                  30          


Leu Arg Arg Thr Pro Leu Tyr Asp Phe His Leu Ala His Gly Gly Lys 
        35                  40                  45              


Met Val Ala Phe Ala Gly Trp Ser Leu Pro Val Gln Tyr Arg Asp Ser 
    50                  55                  60                  


His Thr Asp Ser His Leu His Thr Arg Gln His Cys Ser Leu Phe Asp 
65                  70                  75                  80  


Val Ser His Met Leu Gln Thr Lys Ile Leu Gly Ser Asp Arg Val Lys 
                85                  90                  95      


Leu Met Glu Ser Leu Val Val Gly Asp Ile Ala Glu Leu Arg Pro Asn 
            100                 105                 110         


Gln Gly Thr Leu Ser Leu Phe Thr Asn Glu Ala Gly Gly Ile Leu Asp 
        115                 120                 125             


Asp Leu Ile Val Thr Asn Thr Ser Glu Gly His Leu Tyr Val Val Ser 
    130                 135                 140                 


Asn Ala Gly Cys Trp Glu Lys Asp Leu Ala Leu Met Gln Asp Lys Val 
145                 150                 155                 160 


Arg Glu Leu Gln Asn Gln Gly Arg Asp Val Gly Leu Glu Val Leu Asp 
                165                 170                 175     


Asn Ala Leu Leu Ala Leu Gln Gly Pro Thr Ala Ala Gln Val Leu Gln 
            180                 185                 190         


Ala Gly Val Ala Asp Asp Leu Arg Lys Leu Pro Phe Met Thr Ser Ala 
        195                 200                 205             


Val Met Glu Val Phe Gly Val Ser Gly Cys Arg Val Thr Arg Cys Gly 
    210                 215                 220                 


Tyr Thr Gly Glu Asp Gly Val Glu Ile Ser Val Pro Val Ala Gly Ala 
225                 230                 235                 240 


Val His Leu Ala Thr Ala Ile Leu Lys Asn Pro Glu Val Lys Leu Ala 
                245                 250                 255     


Gly Leu Ala Ala Arg Asp Ser Leu Arg Leu Glu Ala Gly Leu Cys Leu 
            260                 265                 270         


Tyr Gly Asn Asp Ile Asp Glu His Thr Thr Pro Val Glu Gly Ser Leu 
        275                 280                 285             


Ser Trp Thr Leu Gly Lys Arg Arg Arg Ala Ala Met Asp Phe Pro Gly 
    290                 295                 300                 


Ala Lys Val Ile Val Pro Gln Leu Lys Gly Arg Val Gln Arg Arg Arg 
305                 310                 315                 320 


Val Gly Leu Met Cys Glu Gly Ala Pro Met Arg Ala His Ser Pro Ile 
                325                 330                 335     


Leu Asn Met Glu Gly Thr Lys Ile Gly Thr Val Thr Ser Gly Cys Pro 
            340                 345                 350         


Ser Pro Ser Leu Lys Lys Asn Val Ala Met Gly Tyr Val Pro Cys Glu 
        355                 360                 365             


Tyr Ser Arg Pro Gly Thr Met Leu Leu Val Glu Val Arg Arg Lys Gln 
    370                 375                 380                 


Gln Met Ala Val Val Ser Lys Met Pro Phe Val Pro Thr Asn Tyr Tyr 
385                 390                 395                 400 


Thr Leu Lys 
            


<210> 11
<211> 3820
<212> DNA
<213> Homo sapiens

<400> 11
ctttgcgcga gtgtcttggt tgagcgcagc gcccattcat tgcccgcgag cgtccatcca       60

tctgtccggc cgactgtcca gcgaaagggg ctccaggccg ggcgcagccg ccacccgggg      120

gaccgaggcc aggagagggg ccaagagcgc ggctgaccct tgcgggccgg ggcaggggac      180

ggtggccgcg gccatgcagt cctgtgccag ggcgtggggg ctgcgcctgg gccgcggggt      240

cgggggcggc cgccgcctgg ctgggggatc ggggccgtgc tgggcgccgc ggagccggga      300

cagcagcagt ggcggcgggg acagcgccgc ggctggggcc tcgcgcctcc tggagcgcct      360

tctgcccaga cacgacgact tcgctcggag gcacatcggc cctggggaca aagaccagag      420

agagatgctg cagaccttgg ggctggcgag cattgatgaa ttgatcgaga agacggtccc      480

tgccaacatc cgtttgaaaa gacccttgaa aatggaagac cctgtttgtg aaaatgaaat      540

ccttgcaact ctgcatgcca tttcaagcaa aaaccagatc tggagatcgt atattggcat      600

gggctattat aactgctcag tgccacagac gattttgcgg aacttactgg agaactcagg      660

atggatcacc cagtatactc cataccagcc tgaggtgtct caggggaggc tggagagttt      720

actcaactac cagaccatgg tgtgtgacat cacaggcctg gacatggcca atgcatccct      780

gctggatgag gggactgcag ccgcagaggc actgcagctg tgctacagac acaacaagag      840

gaggaaattt ctcgttgatc cccgttgcca cccacagaca atagctgttg tccagactcg      900

agccaaatat actggagtcc tcactgagct gaagttaccc tgtgaaatgg acttcagtgg      960

aaaagatgtc agtggagtgt tgttccagta cccagacacg gaggggaagg tggaagactt     1020

tacggaactc gtggagagag ctcatcagag tgggagcctg gcctgctgtg ctactgacct     1080

tttagctttg tgcatcttga ggccacctgg agaatttggg gtagacatcg ccctgggcag     1140

ctcccagaga tttggagtgc cactgggcta tgggggaccc catgcagcat tttttgctgt     1200

ccgagaaagc ttggtgagaa tgatgcctgg aagaatggtg ggggtaacaa gagatgccac     1260

tgggaaagaa gtgtatcgtc ttgctcttca aaccagggag caacacattc ggagagacaa     1320

ggctaccagc aacatctgta cagctcaggc cctcttggcg aatatggctg ccatgtttgc     1380

aatctaccat ggttcccatg ggctggagca tattgctagg agggtacata atgccacttt     1440

gattttgtca gaaggtctca agcgagcagg gcatcaactc cagcatgacc tgttctttga     1500

taccttgaag attcagtgtg gctgctcagt gaaggaggtc ttgggcaggg ccgctcagcg     1560

gcagatcaat tttcggcttt ttgaggatgg cacacttggt atttctcttg atgaaacagt     1620

caatgaaaaa gatctggacg atttgttgtg gatctttggt tgtgagtcat ctgcagaact     1680

ggttgctgaa agcatgggag aggagtgcag aggtattcca gggtctgtgt tcaagaggac     1740

cagcccgttc ctcacccatc aagtgttcaa cagctaccac tctgaaacaa acattgtccg     1800

gtacatgaag aaactggaaa ataaagacat ttcccttgtt cacagcatga ttccactggg     1860

atcctgcacc atgaaactga acagttcgtc tgaactcgca cctatcacat ggaaagaatt     1920

tgcaaacatc cacccctttg tgcctctgga tcaagctcaa ggatatcagc agcttttccg     1980

agagcttgag aaggatttgt gtgaactcac aggttatgac caggtctgtt tccagccaaa     2040

cagcggagcc cagggagaat atgctggact ggccactatc cgagcctact taaaccagaa     2100

aggagagggg cacagaacgg tttgcctcat tccgaaatca gcacatggga ccaacccagc     2160

aagtgcccac atggcaggca tgaagattca gcctgtggag gtggataaat atgggaatat     2220

cgatgcagtt cacctcaagg ccatggtgga taagcacaag gagaacctag cagctatcat     2280

gattacatac ccatccacca atggggtgtt tgaagagaac atcagtgacg tgtgtgacct     2340

catccatcaa catggaggac aggtctacct agacggggca aatatgaatg ctcaggtggg     2400

aatctgtcgc cctggagact tcgggtctga tgtctcgcac ctaaatcttc acaagacctt     2460

ctgcattccc cacggaggag gtggtcctgg catggggccc atcggagtga agaaacatct     2520

cgccccgttt ttgcccaatc atcccgtcat ttcactaaag cggaatgagg atgcctgtcc     2580

tgtgggaacc gtcagtgcgg ccccatgggg ctccagttcc atcttgccca tttcctgggc     2640

ttatatcaag atgatgggag gcaagggtct taaacaagcc acggaaactg cgatattaaa     2700

tgccaactac atggccaagc gattagaaac acactacaga attcttttca ggggtgcaag     2760

aggttatgtg ggtcatgaat ttattttgga cacgagaccc ttcaaaaagt ctgcaaatat     2820

tgaggctgtg gatgtggcca agagactcca ggattatgga tttcacgccc ctaccatgtc     2880

ctggcctgtg gcagggaccc tcatggtgga gcccactgag tcggaggaca aggcagagct     2940

ggacagattc tgtgatgcca tgatcagcat tcggcaggaa attgctgaca ttgaggaggg     3000

ccgcatcgac cccagggtca atccgctgaa gatgtctcca cactccctga cctgcgttac     3060

atcttcccac tgggaccggc cttattccag agaggtggca gcattcccac tccccttcgt     3120

gaaaccagag aacaaattct ggccaacgat tgcccggatt gatgacatat atggagatca     3180

gcacctggtt tgtacctgcc cacccatgga agtttatgag tctccatttt ctgaacaaaa     3240

gagggcgtct tcttagtcct ctgtccctaa gtttaaagga ctgatttgat gcctctcccc     3300

agagcatttg ataagcaaga aagatttcat ctcccacccc agcctcaagt aggagtttta     3360

tatactgtgt atatctctgt aatctctgtc aaggtaaatg taaatacagt agctggaggg     3420

agtcgaagct gatggttgga agacggattt gctttggtat tctgcttcca catgtgccag     3480

ttgcctggat tgggagccat tttgtgtttt gcgtagaaag ttttaggaac tttaactttt     3540

aatgtggcaa gtttgcagat gtcatagagg ctatcctgga gacttaatag acattttttt     3600

gttccaaaag agtccatgtg gactgtgcca tctgtgggaa atcccagggc aaatgtttac     3660

attttgtata ccctgaagaa ctctttttcc tctaatatgc ctaatctgta atcacatttc     3720

tgagtgttct cctctttttc tgtgtgaggt tttttttttt ttaatctgca tttattagta     3780

ttctaataaa agcatcttga tcggaagaaa aaaaaaaaaa                           3820


<210> 12
<211> 1020
<212> PRT
<213> Homo sapiens

<400> 12
Met Gln Ser Cys Ala Arg Ala Trp Gly Leu Arg Leu Gly Arg Gly Val 
1               5                   10                  15      


Gly Gly Gly Arg Arg Leu Ala Gly Gly Ser Gly Pro Cys Trp Ala Pro 
            20                  25                  30          


Arg Ser Arg Asp Ser Ser Ser Gly Gly Gly Asp Ser Ala Ala Ala Gly 
        35                  40                  45              


Ala Ser Arg Leu Leu Glu Arg Leu Leu Pro Arg His Asp Asp Phe Ala 
    50                  55                  60                  


Arg Arg His Ile Gly Pro Gly Asp Lys Asp Gln Arg Glu Met Leu Gln 
65                  70                  75                  80  


Thr Leu Gly Leu Ala Ser Ile Asp Glu Leu Ile Glu Lys Thr Val Pro 
                85                  90                  95      


Ala Asn Ile Arg Leu Lys Arg Pro Leu Lys Met Glu Asp Pro Val Cys 
            100                 105                 110         


Glu Asn Glu Ile Leu Ala Thr Leu His Ala Ile Ser Ser Lys Asn Gln 
        115                 120                 125             


Ile Trp Arg Ser Tyr Ile Gly Met Gly Tyr Tyr Asn Cys Ser Val Pro 
    130                 135                 140                 


Gln Thr Ile Leu Arg Asn Leu Leu Glu Asn Ser Gly Trp Ile Thr Gln 
145                 150                 155                 160 


Tyr Thr Pro Tyr Gln Pro Glu Val Ser Gln Gly Arg Leu Glu Ser Leu 
                165                 170                 175     


Leu Asn Tyr Gln Thr Met Val Cys Asp Ile Thr Gly Leu Asp Met Ala 
            180                 185                 190         


Asn Ala Ser Leu Leu Asp Glu Gly Thr Ala Ala Ala Glu Ala Leu Gln 
        195                 200                 205             


Leu Cys Tyr Arg His Asn Lys Arg Arg Lys Phe Leu Val Asp Pro Arg 
    210                 215                 220                 


Cys His Pro Gln Thr Ile Ala Val Val Gln Thr Arg Ala Lys Tyr Thr 
225                 230                 235                 240 


Gly Val Leu Thr Glu Leu Lys Leu Pro Cys Glu Met Asp Phe Ser Gly 
                245                 250                 255     


Lys Asp Val Ser Gly Val Leu Phe Gln Tyr Pro Asp Thr Glu Gly Lys 
            260                 265                 270         


Val Glu Asp Phe Thr Glu Leu Val Glu Arg Ala His Gln Ser Gly Ser 
        275                 280                 285             


Leu Ala Cys Cys Ala Thr Asp Leu Leu Ala Leu Cys Ile Leu Arg Pro 
    290                 295                 300                 


Pro Gly Glu Phe Gly Val Asp Ile Ala Leu Gly Ser Ser Gln Arg Phe 
305                 310                 315                 320 


Gly Val Pro Leu Gly Tyr Gly Gly Pro His Ala Ala Phe Phe Ala Val 
                325                 330                 335     


Arg Glu Ser Leu Val Arg Met Met Pro Gly Arg Met Val Gly Val Thr 
            340                 345                 350         


Arg Asp Ala Thr Gly Lys Glu Val Tyr Arg Leu Ala Leu Gln Thr Arg 
        355                 360                 365             


Glu Gln His Ile Arg Arg Asp Lys Ala Thr Ser Asn Ile Cys Thr Ala 
    370                 375                 380                 


Gln Ala Leu Leu Ala Asn Met Ala Ala Met Phe Ala Ile Tyr His Gly 
385                 390                 395                 400 


Ser His Gly Leu Glu His Ile Ala Arg Arg Val His Asn Ala Thr Leu 
                405                 410                 415     


Ile Leu Ser Glu Gly Leu Lys Arg Ala Gly His Gln Leu Gln His Asp 
            420                 425                 430         


Leu Phe Phe Asp Thr Leu Lys Ile Gln Cys Gly Cys Ser Val Lys Glu 
        435                 440                 445             


Val Leu Gly Arg Ala Ala Gln Arg Gln Ile Asn Phe Arg Leu Phe Glu 
    450                 455                 460                 


Asp Gly Thr Leu Gly Ile Ser Leu Asp Glu Thr Val Asn Glu Lys Asp 
465                 470                 475                 480 


Leu Asp Asp Leu Leu Trp Ile Phe Gly Cys Glu Ser Ser Ala Glu Leu 
                485                 490                 495     


Val Ala Glu Ser Met Gly Glu Glu Cys Arg Gly Ile Pro Gly Ser Val 
            500                 505                 510         


Phe Lys Arg Thr Ser Pro Phe Leu Thr His Gln Val Phe Asn Ser Tyr 
        515                 520                 525             


His Ser Glu Thr Asn Ile Val Arg Tyr Met Lys Lys Leu Glu Asn Lys 
    530                 535                 540                 


Asp Ile Ser Leu Val His Ser Met Ile Pro Leu Gly Ser Cys Thr Met 
545                 550                 555                 560 


Lys Leu Asn Ser Ser Ser Glu Leu Ala Pro Ile Thr Trp Lys Glu Phe 
                565                 570                 575     


Ala Asn Ile His Pro Phe Val Pro Leu Asp Gln Ala Gln Gly Tyr Gln 
            580                 585                 590         


Gln Leu Phe Arg Glu Leu Glu Lys Asp Leu Cys Glu Leu Thr Gly Tyr 
        595                 600                 605             


Asp Gln Val Cys Phe Gln Pro Asn Ser Gly Ala Gln Gly Glu Tyr Ala 
    610                 615                 620                 


Gly Leu Ala Thr Ile Arg Ala Tyr Leu Asn Gln Lys Gly Glu Gly His 
625                 630                 635                 640 


Arg Thr Val Cys Leu Ile Pro Lys Ser Ala His Gly Thr Asn Pro Ala 
                645                 650                 655     


Ser Ala His Met Ala Gly Met Lys Ile Gln Pro Val Glu Val Asp Lys 
            660                 665                 670         


Tyr Gly Asn Ile Asp Ala Val His Leu Lys Ala Met Val Asp Lys His 
        675                 680                 685             


Lys Glu Asn Leu Ala Ala Ile Met Ile Thr Tyr Pro Ser Thr Asn Gly 
    690                 695                 700                 


Val Phe Glu Glu Asn Ile Ser Asp Val Cys Asp Leu Ile His Gln His 
705                 710                 715                 720 


Gly Gly Gln Val Tyr Leu Asp Gly Ala Asn Met Asn Ala Gln Val Gly 
                725                 730                 735     


Ile Cys Arg Pro Gly Asp Phe Gly Ser Asp Val Ser His Leu Asn Leu 
            740                 745                 750         


His Lys Thr Phe Cys Ile Pro His Gly Gly Gly Gly Pro Gly Met Gly 
        755                 760                 765             


Pro Ile Gly Val Lys Lys His Leu Ala Pro Phe Leu Pro Asn His Pro 
    770                 775                 780                 


Val Ile Ser Leu Lys Arg Asn Glu Asp Ala Cys Pro Val Gly Thr Val 
785                 790                 795                 800 


Ser Ala Ala Pro Trp Gly Ser Ser Ser Ile Leu Pro Ile Ser Trp Ala 
                805                 810                 815     


Tyr Ile Lys Met Met Gly Gly Lys Gly Leu Lys Gln Ala Thr Glu Thr 
            820                 825                 830         


Ala Ile Leu Asn Ala Asn Tyr Met Ala Lys Arg Leu Glu Thr His Tyr 
        835                 840                 845             


Arg Ile Leu Phe Arg Gly Ala Arg Gly Tyr Val Gly His Glu Phe Ile 
    850                 855                 860                 


Leu Asp Thr Arg Pro Phe Lys Lys Ser Ala Asn Ile Glu Ala Val Asp 
865                 870                 875                 880 


Val Ala Lys Arg Leu Gln Asp Tyr Gly Phe His Ala Pro Thr Met Ser 
                885                 890                 895     


Trp Pro Val Ala Gly Thr Leu Met Val Glu Pro Thr Glu Ser Glu Asp 
            900                 905                 910         


Lys Ala Glu Leu Asp Arg Phe Cys Asp Ala Met Ile Ser Ile Arg Gln 
        915                 920                 925             


Glu Ile Ala Asp Ile Glu Glu Gly Arg Ile Asp Pro Arg Val Asn Pro 
    930                 935                 940                 


Leu Lys Met Ser Pro His Ser Leu Thr Cys Val Thr Ser Ser His Trp 
945                 950                 955                 960 


Asp Arg Pro Tyr Ser Arg Glu Val Ala Ala Phe Pro Leu Pro Phe Val 
                965                 970                 975     


Lys Pro Glu Asn Lys Phe Trp Pro Thr Ile Ala Arg Ile Asp Asp Ile 
            980                 985                 990         


Tyr Gly Asp Gln His Leu Val Cys  Thr Cys Pro Pro Met  Glu Val Tyr 
        995                 1000                 1005             


Glu Ser  Pro Phe Ser Glu Gln  Lys Arg Ala Ser Ser  
    1010                 1015                 1020 


<210> 13
<211> 413
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic consensus
      polypeptide


<220>
<221> MOD_RES
<222> (7)..(29)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(42)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (46)..(48)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (50)..(52)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (69)..(74)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (76)..(79)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (81)..(83)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (92)..(97)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (101)..(105)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (107)..(108)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (117)..(120)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (124)..(126)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (132)..(134)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (137)..(147)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (156)..(157)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (160)..(173)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (178)..(184)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (186)..(187)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (189)..(190)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (194)..(197)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (201)..(205)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (207)..(208)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (213)..(221)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (223)..(225)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (227)..(228)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (245)..(247)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (253)..(255)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (257)..(260)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (264)..(266)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (287)..(292)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (296)..(297)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (301)..(302)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (308)..(311)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (316)..(317)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (319)..(320)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (324)..(329)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (333)..(336)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (342)..(350)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (352)..(354)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (356)..(357)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (361)..(362)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (367)..(368)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (376)..(382)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (385)..(389)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (394)..(400)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (406)..(408)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (411)..(413)
<223> Any amino acid

<400> 13
Met Arg Gly Gly Ser Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr Xaa Leu Xaa Xaa Xaa 
        35                  40                  45              


His Xaa Xaa Xaa Gly Gly Xaa Met Val Xaa Phe Ala Gly Trp Xaa Xaa 
    50                  55                  60                  


Pro Xaa Gln Tyr Xaa Xaa Xaa Xaa Xaa Xaa Ser Xaa Xaa Xaa Xaa Arg 
65                  70                  75                  80  


Xaa Xaa Xaa Ser Xaa Phe Asp Val Xaa His Met Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Gly Xaa Asp Xaa Xaa Xaa Xaa Xaa Glu Xaa Xaa Val Val Xaa Asp 
            100                 105                 110         


Xaa Ala Xaa Leu Xaa Xaa Xaa Xaa Gly Xaa Leu Xaa Xaa Xaa Thr Asn 
        115                 120                 125             


Glu Xaa Gly Xaa Xaa Xaa Asp Asp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Tyr Xaa Val Xaa Asn Ala Gly Cys Xaa Xaa Lys Asp Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Asp 
                165                 170                 175     


Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa Leu Xaa Xaa Gln Gly 
            180                 185                 190         


Pro Xaa Xaa Xaa Xaa Val Leu Gln Xaa Xaa Xaa Xaa Xaa Asp Xaa Xaa 
        195                 200                 205             


Lys Leu Xaa Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa 
    210                 215                 220                 


Xaa Cys Xaa Xaa Thr Arg Xaa Gly Tyr Thr Gly Glu Asp Gly Xaa Glu 
225                 230                 235                 240 


Ile Ser Val Pro Xaa Xaa Xaa Ala Val Xaa Leu Ala Xaa Xaa Xaa Leu 
                245                 250                 255     


Xaa Xaa Xaa Xaa Gly Lys Val Xaa Xaa Xaa Gly Leu Xaa Ala Arg Asp 
            260                 265                 270         


Ser Leu Arg Leu Glu Ala Gly Leu Cys Leu Tyr Gly Asn Asp Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Pro Val Glu Xaa Xaa Leu Xaa Trp Xaa Xaa Gly Lys 
    290                 295                 300                 


Arg Arg Arg Xaa Xaa Xaa Xaa Phe Xaa Gly Ala Xaa Xaa Ile Xaa Xaa 
305                 310                 315                 320 


Gln Xaa Lys Xaa Xaa Xaa Xaa Xaa Xaa Arg Val Gly Xaa Xaa Xaa Xaa 
                325                 330                 335     


Gly Xaa Pro Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa 
            340                 345                 350         


Xaa Xaa Gly Xaa Xaa Thr Ser Gly Xaa Xaa Ser Pro Xaa Leu Xaa Xaa 
        355                 360                 365             


Asn Xaa Ala Met Gly Tyr Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Thr 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Val Arg Xaa Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Lys Met Pro Phe Val Xaa Xaa Xaa Tyr Tyr Xaa Xaa Xaa 
                405                 410             


<210> 14
<211> 403
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Any amino acid

<400> 14
Met Gln Arg Xaa Val Ser Val Val Ala Arg Leu Gly Phe Arg Leu Gln 
1               5                   10                  15      


Ala Xaa Pro Pro Ala Xaa Cys Arg Pro Leu Ser Xaa Ala Gln Xaa Val 
            20                  25                  30          


Leu Arg Arg Thr Pro Leu Tyr Asp Phe His Leu Ala His Gly Gly Lys 
        35                  40                  45              


Met Val Ala Phe Ala Gly Trp Ser Leu Pro Val Gln Tyr Arg Asp Ser 
    50                  55                  60                  


His Xaa Asp Ser His Leu His Thr Arg Gln His Cys Ser Leu Phe Asp 
65                  70                  75                  80  


Val Ser His Met Leu Gln Thr Lys Ile Xaa Gly Xaa Asp Arg Val Lys 
                85                  90                  95      


Leu Met Glu Ser Leu Val Val Gly Asp Ile Ala Glu Leu Arg Pro Asn 
            100                 105                 110         


Gln Gly Thr Leu Ser Leu Phe Thr Asn Glu Ala Gly Gly Ile Leu Asp 
        115                 120                 125             


Asp Leu Ile Val Thr Asn Thr Ser Glu Gly His Leu Tyr Val Val Ser 
    130                 135                 140                 


Asn Ala Gly Cys Xaa Glu Lys Asp Leu Ala Leu Met Gln Asp Lys Val 
145                 150                 155                 160 


Arg Glu Leu Gln Asn Xaa Gly Arg Asp Val Gly Leu Glu Val Leu Asp 
                165                 170                 175     


Asn Ala Leu Leu Ala Leu Gln Gly Pro Thr Ala Ala Gln Val Leu Gln 
            180                 185                 190         


Ala Gly Val Ala Asp Asp Leu Xaa Lys Leu Pro Phe Met Thr Ser Ala 
        195                 200                 205             


Val Met Glu Val Phe Gly Val Ser Gly Cys Arg Val Thr Arg Cys Gly 
    210                 215                 220                 


Tyr Thr Gly Glu Asp Gly Val Glu Ile Ser Val Pro Xaa Ala Xaa Ala 
225                 230                 235                 240 


Val His Leu Ala Thr Ala Xaa Leu Lys Asn Pro Glu Val Lys Leu Ala 
                245                 250                 255     


Gly Leu Ala Ala Arg Asp Ser Leu Arg Leu Glu Ala Gly Leu Cys Leu 
            260                 265                 270         


Tyr Gly Asn Asp Ile Asp Glu His Thr Thr Pro Val Glu Gly Ser Leu 
        275                 280                 285             


Ser Trp Thr Leu Gly Lys Arg Arg Arg Ala Ala Met Asp Phe Pro Gly 
    290                 295                 300                 


Ala Lys Val Ile Val Pro Gln Leu Lys Gly Xaa Val Gln Arg Arg Arg 
305                 310                 315                 320 


Val Gly Leu Met Cys Glu Gly Ala Pro Xaa Arg Ala His Ser Pro Ile 
                325                 330                 335     


Leu Asn Xaa Glu Gly Thr Xaa Ile Gly Thr Val Thr Ser Gly Cys Pro 
            340                 345                 350         


Ser Pro Ser Leu Lys Lys Asn Val Ala Met Gly Tyr Val Pro Cys Glu 
        355                 360                 365             


Tyr Ser Arg Pro Gly Thr Met Leu Leu Val Glu Val Arg Arg Lys Gln 
    370                 375                 380                 


Gln Met Ala Val Val Ser Lys Met Pro Phe Val Pro Thr Asn Tyr Tyr 
385                 390                 395                 400 


Thr Leu Lys 
            


<210> 15
<211> 403
<212> PRT
<213> Macaca mulatta


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Any amino acid

<400> 15
Met Gln Arg Xaa Val Ser Val Val Ala Xaa Leu Gly Phe Arg Leu Gln 
1               5                   10                  15      


Ala Leu Pro Pro Ala Xaa Cys Arg Pro Leu Ser Xaa Ala Gln Asp Val 
            20                  25                  30          


Leu Arg Arg Thr Pro Leu Tyr Asp Phe His Leu Ala His Gly Gly Lys 
        35                  40                  45              


Met Val Ala Phe Ala Gly Trp Ser Leu Pro Val Gln Tyr Arg Asp Ser 
    50                  55                  60                  


His Xaa Asp Ser His Leu His Thr Arg Gln His Cys Ser Leu Phe Asp 
65                  70                  75                  80  


Val Ser His Met Leu Gln Thr Lys Ile Phe Gly Xaa Asp Arg Val Lys 
                85                  90                  95      


Leu Met Glu Ser Leu Val Val Gly Asp Ile Ala Glu Leu Arg Pro Asn 
            100                 105                 110         


Gln Gly Thr Leu Ser Leu Phe Thr Asn Glu Ala Gly Gly Ile Leu Asp 
        115                 120                 125             


Asp Leu Ile Val Thr Asn Thr Ser Glu Gly His Leu Tyr Val Val Ser 
    130                 135                 140                 


Asn Ala Gly Cys Xaa Glu Lys Asp Leu Ala Leu Met Gln Asp Lys Val 
145                 150                 155                 160 


Arg Glu Leu Gln Asn Xaa Gly Arg Asp Val Gly Leu Glu Val Leu Asp 
                165                 170                 175     


Asn Ala Leu Leu Ala Leu Gln Gly Pro Thr Ala Ala Gln Val Leu Gln 
            180                 185                 190         


Ala Xaa Val Ala Asp Asp Leu Xaa Lys Leu Pro Phe Met Thr Ser Ala 
        195                 200                 205             


Val Met Glu Val Phe Gly Val Ser Gly Cys Arg Val Thr Arg Cys Gly 
    210                 215                 220                 


Tyr Thr Gly Glu Asp Gly Val Glu Ile Ser Val Pro Ala Ala Xaa Ala 
225                 230                 235                 240 


Val His Leu Ala Thr Ala Leu Leu Lys Asn Pro Glu Val Lys Leu Ala 
                245                 250                 255     


Gly Leu Ala Ala Arg Asp Ser Leu Arg Leu Glu Ala Gly Leu Cys Leu 
            260                 265                 270         


Tyr Gly Asn Asp Ile Asp Glu His Thr Thr Pro Val Glu Gly Ser Leu 
        275                 280                 285             


Ser Trp Thr Leu Gly Lys Arg Arg Arg Ala Ala Met Asp Phe Pro Gly 
    290                 295                 300                 


Ala Lys Val Ile Val Pro Gln Leu Lys Gly Lys Val Gln Arg Arg Arg 
305                 310                 315                 320 


Val Gly Leu Met Cys Glu Gly Ala Pro Xaa Arg Ala His Ser Pro Ile 
                325                 330                 335     


Leu Asn Xaa Glu Gly Thr Xaa Ile Gly Thr Val Thr Ser Gly Cys Pro 
            340                 345                 350         


Ser Pro Ser Leu Lys Lys Asn Val Ala Met Gly Tyr Val Pro Cys Glu 
        355                 360                 365             


Tyr Ser Arg Pro Gly Thr Met Leu Leu Val Glu Val Arg Arg Lys Gln 
    370                 375                 380                 


Gln Met Ala Val Val Ser Lys Met Pro Phe Val Pro Thr Asn Tyr Tyr 
385                 390                 395                 400 


Thr Leu Lys 
            


<210> 16
<211> 397
<212> PRT
<213> Bos taurus


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(7)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(14)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (60)..(61)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (128)..(129)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (332)..(333)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Any amino acid

<400> 16
Xaa Val Xaa Arg Leu Xaa Xaa Arg Leu Gln Ala Leu Xaa Xaa Ala Xaa 
1               5                   10                  15      


Cys Arg Xaa Leu Ser Xaa Ala Gln Asp Val Leu Xaa Arg Thr Pro Leu 
            20                  25                  30          


Tyr Asp Phe His Leu Ala His Gly Gly Lys Met Val Ala Phe Ala Gly 
        35                  40                  45              


Trp Ser Leu Pro Val Gln Tyr Arg Asp Ser His Xaa Xaa Ser His Leu 
    50                  55                  60                  


His Thr Arg Gln His Cys Ser Leu Phe Asp Val Ser His Met Leu Gln 
65                  70                  75                  80  


Thr Lys Ile Phe Gly Xaa Asp Arg Val Lys Leu Met Glu Ser Leu Val 
                85                  90                  95      


Val Gly Asp Ile Ala Glu Leu Xaa Pro Asn Gln Gly Thr Leu Ser Leu 
            100                 105                 110         


Phe Thr Asn Glu Ala Gly Gly Ile Leu Asp Asp Leu Ile Val Thr Xaa 
        115                 120                 125             


Xaa Ser Glu Gly His Leu Tyr Val Val Ser Asn Ala Gly Cys Arg Glu 
    130                 135                 140                 


Lys Asp Leu Xaa Leu Met Gln Asp Lys Val Arg Glu Leu Gln Asn Xaa 
145                 150                 155                 160 


Gly Xaa Asp Val Xaa Leu Glu Val Xaa Asp Asn Ala Leu Leu Ala Leu 
                165                 170                 175     


Gln Gly Pro Thr Ala Ala Gln Val Leu Gln Ala Gly Val Ala Asp Asp 
            180                 185                 190         


Leu Xaa Lys Leu Pro Phe Met Thr Ser Ala Val Met Glu Val Phe Gly 
        195                 200                 205             


Val Ser Gly Cys Arg Val Thr Arg Cys Gly Tyr Thr Gly Glu Asp Gly 
    210                 215                 220                 


Val Glu Ile Ser Val Pro Ala Ala Xaa Ala Val His Leu Ala Xaa Ala 
225                 230                 235                 240 


Leu Leu Lys Asn Pro Glu Val Lys Leu Ala Gly Leu Ala Ala Arg Asp 
                245                 250                 255     


Ser Leu Arg Leu Glu Ala Gly Leu Cys Leu Tyr Gly Asn Asp Ile Asp 
            260                 265                 270         


Glu His Thr Thr Pro Val Glu Gly Ser Leu Ser Trp Thr Leu Gly Lys 
        275                 280                 285             


Arg Arg Arg Ala Ala Met Asp Phe Pro Gly Ala Xaa Val Ile Val Pro 
    290                 295                 300                 


Gln Leu Lys Xaa Lys Xaa Gln Arg Arg Arg Val Gly Leu Met Cys Xaa 
305                 310                 315                 320 


Gly Ala Pro Val Arg Ala Xaa Ser Pro Ile Leu Xaa Xaa Glu Gly Thr 
                325                 330                 335     


Xaa Ile Gly Xaa Val Thr Ser Gly Cys Pro Ser Pro Xaa Leu Lys Lys 
            340                 345                 350         


Asn Val Ala Met Gly Tyr Val Pro Xaa Glu Tyr Ser Arg Pro Gly Thr 
        355                 360                 365             


Xaa Leu Leu Val Glu Val Arg Arg Lys Gln Gln Xaa Ala Val Val Ser 
    370                 375                 380                 


Lys Met Pro Phe Val Xaa Thr Asn Tyr Tyr Xaa Leu Lys 
385                 390                 395         


<210> 17
<211> 393
<212> PRT
<213> Gallus sp.


<220>
<221> MOD_RES
<222> (1)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(12)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (19)..(21)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (23)..(24)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (28)..(30)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (51)..(53)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (77)..(79)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (85)..(87)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (138)..(139)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (146)..(150)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (153)..(155)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (164)..(167)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (169)..(172)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (176)..(177)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (185)..(186)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (198)..(201)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (228)..(229)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (235)..(236)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (239)..(240)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (244)..(245)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (276)..(277)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (296)..(297)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (299)..(300)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (314)..(316)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (322)..(325)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (328)..(329)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (333)..(334)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (356)..(359)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (375)..(376)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (391)..(392)
<223> Any amino acid

<400> 17
Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa Leu Ser 
1               5                   10                  15      


Xaa Ala Xaa Xaa Xaa Leu Xaa Xaa Thr Pro Leu Xaa Xaa Xaa His Xaa 
            20                  25                  30          


Ala Xaa Gly Gly Xaa Met Val Xaa Phe Ala Gly Trp Ser Leu Pro Val 
        35                  40                  45              


Gln Tyr Xaa Xaa Xaa His Xaa Xaa Ser His Leu His Thr Arg Xaa His 
    50                  55                  60                  


Cys Ser Leu Phe Asp Val Ser His Met Leu Gln Thr Xaa Xaa Xaa Gly 
65                  70                  75                  80  


Xaa Asp Arg Val Xaa Xaa Xaa Glu Ser Leu Val Val Gly Asp Ile Ala 
                85                  90                  95      


Glu Leu Arg Pro Xaa Gln Gly Thr Leu Xaa Leu Xaa Thr Asn Glu Xaa 
            100                 105                 110         


Gly Xaa Ile Xaa Asp Asp Leu Ile Val Thr Asn Thr Xaa Glu Xaa His 
        115                 120                 125             


Leu Tyr Val Val Ser Asn Ala Gly Cys Xaa Xaa Lys Asp Xaa Ala Xaa 
    130                 135                 140                 


Met Xaa Xaa Xaa Xaa Xaa Glu Leu Xaa Xaa Xaa Gly Xaa Asp Val Xaa 
145                 150                 155                 160 


Leu Glu Val Xaa Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa Gln Gly Pro Xaa 
                165                 170                 175     


Xaa Ala Gln Val Leu Gln Ala Gly Xaa Xaa Asp Asp Leu Xaa Lys Leu 
            180                 185                 190         


Xaa Phe Met Thr Ser Xaa Xaa Xaa Xaa Val Phe Gly Val Xaa Gly Cys 
        195                 200                 205             


Arg Val Thr Arg Cys Gly Tyr Thr Gly Glu Asp Gly Val Glu Ile Ser 
    210                 215                 220                 


Val Pro Ala Xaa Xaa Ala Val Xaa Leu Ala Xaa Xaa Leu Leu Xaa Xaa 
225                 230                 235                 240 


Pro Glu Val Xaa Xaa Ala Gly Leu Ala Ala Arg Asp Ser Leu Arg Leu 
                245                 250                 255     


Glu Ala Gly Leu Cys Leu Tyr Gly Asn Asp Ile Asp Glu Xaa Thr Thr 
            260                 265                 270         


Pro Val Glu Xaa Xaa Leu Xaa Trp Thr Leu Gly Lys Arg Arg Arg Xaa 
        275                 280                 285             


Ala Met Asp Phe Pro Gly Ala Xaa Xaa Ile Xaa Xaa Gln Xaa Lys Xaa 
    290                 295                 300                 


Lys Xaa Xaa Arg Xaa Arg Val Gly Leu Xaa Xaa Xaa Gly Xaa Pro Xaa 
305                 310                 315                 320 


Arg Xaa Xaa Xaa Xaa Ile Leu Xaa Xaa Glu Gly Thr Xaa Xaa Gly Thr 
                325                 330                 335     


Val Thr Ser Gly Cys Pro Ser Pro Ser Leu Xaa Lys Asn Xaa Ala Met 
            340                 345                 350         


Gly Tyr Val Xaa Xaa Xaa Xaa Ser Arg Pro Gly Thr Xaa Leu Xaa Val 
        355                 360                 365             


Glu Val Arg Xaa Lys Gln Xaa Xaa Ala Xaa Val Xaa Lys Met Pro Phe 
    370                 375                 380                 


Val Pro Thr Xaa Tyr Tyr Xaa Xaa Lys 
385                 390             


<210> 18
<211> 403
<212> PRT
<213> Mus musculus


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (20)..(23)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (28)..(29)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (175)..(176)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (199)..(200)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (238)..(239)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (367)..(368)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Any amino acid

<400> 18
Met Xaa Arg Xaa Val Ser Val Val Ala Xaa Leu Gly Phe Arg Leu Gln 
1               5                   10                  15      


Ala Xaa Pro Xaa Xaa Xaa Xaa Arg Pro Leu Ser Xaa Xaa Gln Asp Val 
            20                  25                  30          


Leu Arg Arg Thr Pro Leu Tyr Asp Phe His Leu Ala His Gly Gly Lys 
        35                  40                  45              


Met Val Ala Phe Ala Gly Trp Ser Leu Pro Val Gln Tyr Arg Asp Ser 
    50                  55                  60                  


His Xaa Asp Ser His Leu His Thr Arg Xaa His Cys Ser Leu Phe Asp 
65                  70                  75                  80  


Val Ser His Met Leu Gln Thr Lys Ile Phe Gly Xaa Asp Arg Val Lys 
                85                  90                  95      


Leu Xaa Glu Ser Xaa Val Val Gly Asp Ile Ala Glu Leu Arg Pro Asn 
            100                 105                 110         


Gln Gly Thr Leu Ser Leu Phe Thr Asn Glu Ala Gly Gly Ile Leu Asp 
        115                 120                 125             


Asp Leu Ile Val Xaa Asn Thr Ser Glu Gly His Leu Tyr Val Val Ser 
    130                 135                 140                 


Asn Ala Gly Cys Arg Xaa Lys Asp Leu Ala Leu Met Gln Asp Lys Val 
145                 150                 155                 160 


Xaa Glu Xaa Gln Asn Xaa Gly Xaa Asp Val Gly Leu Glu Val Xaa Xaa 
                165                 170                 175     


Asn Ala Leu Leu Ala Leu Gln Gly Pro Thr Ala Xaa Gln Val Leu Gln 
            180                 185                 190         


Ala Gly Val Xaa Asp Asp Xaa Xaa Lys Leu Pro Phe Met Thr Ser Ala 
        195                 200                 205             


Val Met Glu Val Phe Gly Val Ser Gly Cys Arg Val Thr Arg Cys Gly 
    210                 215                 220                 


Tyr Thr Gly Glu Asp Gly Val Glu Ile Ser Val Pro Ala Xaa Xaa Ala 
225                 230                 235                 240 


Val His Leu Ala Thr Xaa Leu Leu Lys Asn Pro Glu Val Lys Leu Ala 
                245                 250                 255     


Gly Leu Ala Ala Arg Asp Ser Leu Arg Leu Glu Ala Gly Leu Cys Leu 
            260                 265                 270         


Tyr Gly Asn Asp Ile Asp Glu His Thr Thr Pro Val Glu Gly Ser Leu 
        275                 280                 285             


Ser Trp Thr Leu Gly Lys Arg Arg Arg Xaa Ala Met Asp Phe Pro Gly 
    290                 295                 300                 


Ala Lys Xaa Ile Val Pro Gln Leu Lys Gly Xaa Val Gln Arg Arg Arg 
305                 310                 315                 320 


Val Gly Leu Xaa Cys Glu Gly Ala Pro Val Arg Ala His Ser Pro Ile 
                325                 330                 335     


Leu Asn Xaa Glu Gly Thr Xaa Ile Gly Thr Val Thr Ser Gly Cys Pro 
            340                 345                 350         


Ser Pro Ser Leu Lys Lys Asn Val Ala Met Gly Tyr Val Pro Xaa Xaa 
        355                 360                 365             


Tyr Ser Arg Pro Gly Thr Xaa Leu Leu Val Glu Val Arg Arg Lys Gln 
    370                 375                 380                 


Gln Met Xaa Val Val Ser Lys Met Pro Phe Val Pro Thr Asn Tyr Tyr 
385                 390                 395                 400 


Thr Leu Lys 
            


<210> 19
<211> 404
<212> PRT
<213> Xenopus sp.


<220>
<221> MOD_RES
<222> (4)..(16)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(23)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (25)..(26)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (28)..(29)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(34)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (67)..(68)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (90)..(91)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (96)..(98)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (111)..(112)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (158)..(159)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (161)..(167)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (175)..(176)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (187)..(188)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (196)..(197)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (209)..(212)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (216)..(217)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (239)..(240)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (246)..(247)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (252)..(253)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (318)..(320)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (325)..(327)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (343)..(344)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (358)..(359)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (367)..(368)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (371)..(373)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (376)..(379)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (385)..(388)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (390)..(391)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (398)..(399)
<223> Any amino acid

<400> 19
Met Gln Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Ala Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa Ser Xaa Xaa Gln Xaa Xaa 
            20                  25                  30          


Xaa Xaa Arg Xaa Thr Pro Leu Tyr Asp Phe His Xaa Xaa His Gly Gly 
        35                  40                  45              


Lys Met Val Xaa Phe Ala Gly Trp Xaa Leu Pro Val Gln Tyr Xaa Asp 
    50                  55                  60                  


Ser His Xaa Xaa Ser His Leu His Thr Arg Gln His Cys Ser Xaa Phe 
65                  70                  75                  80  


Asp Val Ser His Met Leu Gln Thr Lys Xaa Xaa Gly Xaa Asp Arg Xaa 
                85                  90                  95      


Xaa Xaa Met Glu Ser Xaa Val Val Xaa Asp Ile Ala Glu Leu Xaa Xaa 
            100                 105                 110         


Asn Gln Gly Thr Leu Ser Leu Phe Thr Asn Glu Xaa Gly Gly Ile Xaa 
        115                 120                 125             


Asp Asp Leu Ile Val Thr Xaa Thr Ser Xaa Gly Xaa Leu Tyr Val Val 
    130                 135                 140                 


Ser Asn Ala Gly Cys Xaa Glu Lys Asp Xaa Ala Xaa Met Xaa Xaa Lys 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Arg Asp Val Xaa Leu Glu Xaa Xaa 
                165                 170                 175     


Asp Xaa Ala Leu Leu Ala Xaa Gln Gly Pro Xaa Xaa Ala Xaa Val Leu 
            180                 185                 190         


Gln Ala Gly Xaa Xaa Asp Asp Leu Xaa Lys Leu Xaa Phe Met Thr Ser 
        195                 200                 205             


Xaa Xaa Xaa Xaa Val Phe Gly Xaa Xaa Gly Cys Arg Val Thr Arg Cys 
    210                 215                 220                 


Gly Tyr Thr Gly Glu Asp Gly Val Glu Ile Ser Val Pro Ala Xaa Xaa 
225                 230                 235                 240 


Ala Val Xaa Leu Ala Xaa Xaa Leu Leu Xaa Asn Xaa Xaa Val Lys Leu 
                245                 250                 255     


Ala Gly Leu Ala Ala Arg Asp Ser Leu Arg Leu Glu Ala Gly Leu Cys 
            260                 265                 270         


Leu Tyr Gly Asn Asp Ile Asp Glu Xaa Thr Thr Pro Val Glu Xaa Ser 
        275                 280                 285             


Leu Xaa Trp Thr Leu Gly Lys Arg Arg Arg Xaa Ala Met Asp Phe Pro 
    290                 295                 300                 


Gly Ala Xaa Val Ile Val Pro Gln Xaa Lys Gly Lys Val Xaa Xaa Xaa 
305                 310                 315                 320 


Arg Val Gly Leu Xaa Xaa Xaa Gly Xaa Pro Val Arg Xaa His Xaa Pro 
                325                 330                 335     


Ile Leu Asn Xaa Glu Gly Xaa Xaa Ile Gly Xaa Val Thr Ser Gly Cys 
            340                 345                 350         


Pro Ser Pro Ser Leu Xaa Xaa Asn Val Ala Met Gly Tyr Val Xaa Xaa 
        355                 360                 365             


Glu Tyr Xaa Xaa Xaa Gly Thr Xaa Xaa Xaa Xaa Glu Val Arg Xaa Lys 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Val Xaa Xaa Lys Met Pro Phe Val Pro Xaa Xaa Tyr 
385                 390                 395                 400 


Tyr Thr Leu Lys 
                


<210> 20
<211> 413
<212> PRT
<213> Arabidopsis thaliana


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(11)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(15)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(21)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (23)..(29)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(37)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (41)..(42)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (72)..(73)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (76)..(79)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (81)..(83)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (92)..(97)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (103)..(105)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (119)..(120)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (124)..(125)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (133)..(134)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (137)..(139)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (141)..(145)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (162)..(173)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (178)..(182)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (184)..(186)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (201)..(205)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (213)..(221)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (227)..(228)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (245)..(247)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (257)..(259)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (261)..(262)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (287)..(289)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (291)..(292)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (296)..(297)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (301)..(302)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (309)..(311)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (319)..(320)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (324)..(328)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (333)..(336)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (345)..(350)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (352)..(353)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (356)..(357)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (361)..(362)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (376)..(382)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (385)..(389)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (394)..(400)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (411)..(413)
<223> Any amino acid

<400> 20
Met Arg Gly Gly Ser Leu Xaa Gln Xaa Xaa Xaa Ser Xaa Xaa Xaa Arg 
1               5                   10                  15      


Leu Xaa Xaa Xaa Xaa Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Asp Xaa Leu Xaa Xaa Thr Xaa Leu Tyr Asp Phe 
        35                  40                  45              


His Xaa Ala His Gly Gly Lys Met Val Xaa Phe Ala Gly Trp Ser Xaa 
    50                  55                  60                  


Pro Xaa Gln Tyr Xaa Asp Ser Xaa Xaa Asp Ser Xaa Xaa Xaa Xaa Arg 
65                  70                  75                  80  


Xaa Xaa Xaa Ser Leu Phe Asp Val Xaa His Met Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Gly Xaa Asp Xaa Val Xaa Xaa Xaa Glu Xaa Leu Val Val Xaa Asp 
            100                 105                 110         


Xaa Ala Xaa Leu Xaa Pro Xaa Xaa Gly Xaa Leu Xaa Xaa Phe Thr Asn 
        115                 120                 125             


Glu Xaa Gly Gly Xaa Xaa Asp Asp Xaa Xaa Xaa Thr Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa His Xaa Tyr Xaa Val Xaa Asn Ala Gly Cys Arg Xaa Lys Asp Leu 
145                 150                 155                 160 


Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Asp 
                165                 170                 175     


Val Xaa Xaa Xaa Xaa Xaa Asp Xaa Xaa Xaa Leu Leu Ala Leu Gln Gly 
            180                 185                 190         


Pro Xaa Ala Ala Xaa Val Leu Gln Xaa Xaa Xaa Xaa Xaa Asp Leu Xaa 
        195                 200                 205             


Lys Leu Xaa Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Ser 
    210                 215                 220                 


Xaa Cys Xaa Xaa Thr Arg Xaa Gly Tyr Thr Gly Glu Asp Gly Xaa Glu 
225                 230                 235                 240 


Ile Ser Val Pro Xaa Xaa Xaa Ala Val Xaa Leu Ala Xaa Ala Xaa Leu 
                245                 250                 255     


Xaa Xaa Xaa Glu Xaa Xaa Val Xaa Leu Xaa Gly Leu Xaa Ala Arg Asp 
            260                 265                 270         


Ser Leu Arg Leu Glu Ala Gly Leu Cys Leu Tyr Gly Asn Asp Xaa Xaa 
        275                 280                 285             


Xaa His Xaa Xaa Pro Val Glu Xaa Xaa Leu Xaa Trp Xaa Xaa Gly Lys 
    290                 295                 300                 


Arg Arg Arg Ala Xaa Xaa Xaa Phe Xaa Gly Ala Xaa Val Ile Xaa Xaa 
305                 310                 315                 320 


Gln Leu Lys Xaa Xaa Xaa Xaa Xaa Arg Arg Val Gly Xaa Xaa Xaa Xaa 
                325                 330                 335     


Gly Xaa Pro Xaa Arg Xaa His Ser Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa 
            340                 345                 350         


Xaa Ile Gly Xaa Xaa Thr Ser Gly Xaa Xaa Ser Pro Xaa Leu Lys Lys 
        355                 360                 365             


Asn Xaa Ala Met Gly Tyr Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Thr 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Val Arg Xaa Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Lys Met Pro Phe Val Xaa Thr Xaa Tyr Tyr Xaa Xaa Xaa 
                405                 410             


