                         SEQUENCE LISTING

<110>  Affitech Research AS et al. 
 
<120>  Antibodies and uses thereof

<130>  68.107451/02

<150>  GB1020738.9
<151>  2010-12-07

<150>  US61/420370
<151>  2010-12-07

<160>  133   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Tyr Ala Met Ser 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  3

Arg Gly Gly Ser Tyr Phe Asp Tyr 
1               5               


<210>  4
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Gly Ser Thr Ser Asn Ile Gly Ser His Tyr Val Phe 
1               5                   10              


<210>  5
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  5

Arg Asn His Gln Arg Pro Ser 
1               5           


<210>  6
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Val Trp Asp Ala Lys Tyr Arg Gly Trp Val 
1               5                   10      


<210>  7
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser 
            20                  25                  30  


<210>  8
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  8

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  9
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  9

Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  10
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  10

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  11
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  11

Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys Leu Glu Glu Gly Glu Phe 
1               5                   10                  15      


Ser Glu Ala Arg Val 
            20      


<210>  12
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  12

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  13
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  13

Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  14
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  14

Gly Val Pro Asp Arg Leu Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
1               5                   10                  15      


Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  15
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  15

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  16
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  16

Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  17
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  17

Ser Gly Ser Thr Ser Asn Ile Gly Ser His Tyr Val Ser 
1               5                   10              


<210>  18
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  18

Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  19
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Glu Gly Thr Phe Ser 
            20                  25                  30  


<210>  20
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  20

Arg Arg Gly Ala Lys Phe Asp Tyr 
1               5               


<210>  21
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  21

Ser Tyr Val Leu Thr Gln Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  22
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  22

Ser Gly Ser Thr Ser Asn Ile Gly Ser His Tyr Val Val 
1               5                   10              


<210>  23
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Val Pro Asp Arg Leu Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
1               5                   10                  15      


Leu Ala Ile Gly Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  24
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Val Trp Asp Asp Thr Leu Ser Gly Trp Val 
1               5                   10      


<210>  25
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  25

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  26
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  26

Ser Tyr Ala Ile Ser 
1               5   


<210>  27
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  27

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  28
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  28

Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  29
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Gly Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  30
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  30

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser His 
            20                  25                  30          


Tyr Val Phe Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Ala Lys Tyr 
                85                  90                  95      


Arg Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  31
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Gly Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  32
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  32

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser His 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Ala Lys Tyr 
                85                  90                  95      


Arg Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  33
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Gly Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  34
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  34

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser His 
            20                  25                  30          


Tyr Val Phe Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Ala Lys Tyr 
                85                  90                  95      


Arg Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  35
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Glu Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Gly Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  36
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  36

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser His 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Ala Lys Tyr 
                85                  90                  95      


Arg Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  37
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Glu Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Ala Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  38
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  38

Ser Tyr Val Leu Thr Gln Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser His 
            20                  25                  30          


Tyr Val Val Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Gly Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Asp Thr Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  39
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  39

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Glu Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Ala Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  40
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  40

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser His 
            20                  25                  30          


Tyr Val Val Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Gly Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Asp Thr Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  41
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  41

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Ala Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  42
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  42

Ser Tyr Val Leu Thr Gln Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser His 
            20                  25                  30          


Tyr Val Val Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Gly Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Asp Thr Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 


<210>  43
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  43

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Ala Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  44
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  44

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser His 
            20                  25                  30          


Tyr Val Val Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Gly Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Asp Thr Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  45
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  45

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Ala Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  46
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  46

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser His 
            20                  25                  30          


Tyr Val Val Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Gly Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Asp Thr Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  47
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  47

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Gly Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys Leu 
        115                 120                 125             


Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Tyr Val Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Ser Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Thr Ser Asn Ile Gly Ser His Tyr Val Phe Trp Tyr Gln 
                165                 170                 175     


Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu Ile Tyr Arg Asn His Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Leu Ser Gly Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Val Trp Asp Ala Lys Tyr Arg Gly Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  48
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Gly Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys Leu 
        115                 120                 125             


Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Tyr Val Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Ser Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Thr Ser Asn Ile Gly Ser His Tyr Val Ser Trp Tyr Gln 
                165                 170                 175     


Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu Ile Tyr Arg Asn His Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Leu Ser Gly Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Val Trp Asp Ala Lys Tyr Arg Gly Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  49
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  49

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Gly Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys Leu 
        115                 120                 125             


Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Tyr Val Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Ser Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Thr Ser Asn Ile Gly Ser His Tyr Val Phe Trp Tyr Gln 
                165                 170                 175     


Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu Ile Tyr Arg Asn His Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Leu Ser Gly Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Val Trp Asp Ala Lys Tyr Arg Gly Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  50
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  50

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Glu Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Gly Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys Leu 
        115                 120                 125             


Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Tyr Val Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Ser Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Thr Ser Asn Ile Gly Ser His Tyr Val Ser Trp Tyr Gln 
                165                 170                 175     


Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu Ile Tyr Arg Asn His Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Leu Ser Gly Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Val Trp Asp Ala Lys Tyr Arg Gly Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  51
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  51

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Glu Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Ala Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys Leu 
        115                 120                 125             


Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Tyr Val Leu Thr Gln 
    130                 135                 140                 


Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln Ser Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Thr Ser Asn Ile Gly Ser His Tyr Val Val Trp Tyr Gln 
                165                 170                 175     


Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu Ile Tyr Arg Asn His Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Leu Ser Gly Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Gly Gly Leu Arg Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Val Trp Asp Asp Thr Leu Ser Gly Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  52
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  52

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Glu Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Ala Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys Leu 
        115                 120                 125             


Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Tyr Val Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Ser Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Thr Ser Asn Ile Gly Ser His Tyr Val Val Trp Tyr Gln 
                165                 170                 175     


Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu Ile Tyr Arg Asn His Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Leu Ser Gly Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Gly Gly Leu Arg Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Val Trp Asp Asp Thr Leu Ser Gly Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  53
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  53

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Ala Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys Leu 
        115                 120                 125             


Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Tyr Val Leu Thr Gln 
    130                 135                 140                 


Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln Ser Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Thr Ser Asn Ile Gly Ser His Tyr Val Val Trp Tyr Gln 
                165                 170                 175     


Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu Ile Tyr Arg Asn His Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Leu Ser Gly Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Gly Gly Leu Arg Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Val Trp Asp Asp Thr Leu Ser Gly Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val 
                245         


<210>  54
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  54

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Ala Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys Leu 
        115                 120                 125             


Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Tyr Val Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Ser Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Thr Ser Asn Ile Gly Ser His Tyr Val Val Trp Tyr Gln 
                165                 170                 175     


Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu Ile Tyr Arg Asn His Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Leu Ser Gly Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Gly Gly Leu Arg Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Val Trp Asp Asp Thr Leu Ser Gly Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  55
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  55

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Ala Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys Leu 
        115                 120                 125             


Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Tyr Val Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Ser Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Thr Ser Asn Ile Gly Ser His Tyr Val Val Trp Tyr Gln 
                165                 170                 175     


Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu Ile Tyr Arg Asn His Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Leu Ser Gly Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Gly Gly Leu Arg Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Val Trp Asp Asp Thr Leu Ser Gly Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  56
<211>  744
<212>  DNA
<213>  Homo sapiens

<400>  56
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgatgac acggccgtgt attactgtgc gagacgcggt      300

gggagctact ttgactactg gggccaaggg accctggtca ccgtctcctc aaagctttca      360

gggagtgcat ccgccccaaa acttgaagaa ggtgaatttt cagaagcacg cgtatcctat      420

gtgctgactc agccaccctc agcgtctggg acccccgggc agagcgtcac catctcttgt      480

tctggaagca cctccaacat cggaagtcat tatgtgttct ggtaccagca gctcccagga      540

acggccccca gactcctcat ctataggaat catcagcggc cctcaggggt ccctgaccga      600

ctctctggct ccaagtctgg cacctcagcc tccctggcca tcagtgggct ccggtccgag      660

gatgaggctg attattactg tgcagtgtgg gatgcgaaat acaggggttg ggtgttcggc      720

ggagggacca agctgaccgt ccta                                             744


<210>  57
<211>  744
<212>  DNA
<213>  Homo sapiens

<400>  57
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag acctgatgac acggccgtgt attactgtgc gagacgcggt      300

gggagctact ttgactactg gggccaaggg accctggtca ccgtctcctc aaagctttca      360

gggagtgcat ccgccccaaa acttgaagaa ggtgaatttt cagaagcacg cgtatcctat      420

gtgctgactc agccaccctc agcgtctggg acccccgggc agagcgtcac catctcttgt      480

tctggaagca cctccaacat cggaagtcat tatgtgtcct ggtaccagca gctcccagga      540

acggccccca gactcctcat ctataggaat catcagcggc cctcaggggt ccctgaccga      600

ctctctggct ccaagtctgg cacctcagcc tccctggcca tcagtgggct ccggtccgag      660

gatgaggctg attattactg tgcagtgtgg gatgcgaaat acaggggttg ggtgttcggc      720

ggagggacca agctgaccgt ccta                                             744


<210>  58
<211>  744
<212>  DNA
<213>  Homo sapiens

<400>  58
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag acctgatgac acggccgtgt attactgtgc gagacgcggt      300

gggagctact ttgactactg gggccaaggg accctggtca ccgtctcctc aaagctttca      360

gggagtgcat ccgccccaaa acttgaagaa ggtgaatttt cagaagcacg cgtatcctat      420

gtgctgactc agccaccctc agcgtctggg acccccgggc agagcgtcac catctcttgt      480

tctggaagca cctccaacat cggaagtcat tatgtgttct ggtaccagca gctcccagga      540

acggccccca gactcctcat ctataggaat catcagcggc cctcaggggt ccctgaccga      600

ctctctggct ccaagtctgg cacctcagcc tccctggcca tcagtgggct ccggtccgag      660

gatgaggctg attattactg tgcagtgtgg gatgcgaaat acaggggttg ggtgttcggc      720

ggagggacca agctgaccgt ccta                                             744


<210>  59
<211>  744
<212>  DNA
<213>  Homo sapiens

<400>  59
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctgaagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgatgac acggccgtgt attactgtgc gagacgcggt      300

gggagctact ttgactactg gggccaaggg accctggtca ccgtctcctc aaagctttca      360

gggagtgcat ccgccccaaa acttgaagaa ggtgaatttt cagaagcacg cgtatcctat      420

gtgctgactc agccaccctc agcgtctggg acccccgggc agagcgtcac catctcttgt      480

tctggaagca cctccaacat cggaagtcat tatgtgtcct ggtaccagca gctcccagga      540

acggccccca gactcctcat ctataggaat catcagcggc cctcaggggt ccctgaccga      600

ctctctggct ccaagtctgg cacctcagcc tccctggcca tcagtgggct ccggtccgag      660

gatgaggctg attattactg tgcagtgtgg gatgcgaaat acaggggttg ggtgttcggc      720

ggagggacca agctgaccgt ccta                                             744


<210>  60
<211>  744
<212>  DNA
<213>  Homo sapiens

<400>  60
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctgaagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgatgac acggccgtgt attactgtgc gagacggcgc      300

ggcgctaaat ttgactactg gggccaaggg accctggtca ccgtctcctc aaagctttca      360

gggagtgcat ccgccccaaa acttgaagaa ggtgaatttt cagaagcacg cgtatcctat      420

gtgctgactc agcaaccctc agcgtctggg acccccgggc agagcgtcac catctcttgt      480

tctggaagca cctccaacat cggaagtcat tatgtggtct ggtaccagca gctcccagga      540

acggccccca gactcctcat ctataggaat catcagcggc cctcaggggt ccctgaccga      600

ctctctggct ccaagtctgg cacctcagcc tccctggcca tcggtgggct ccggtccgag      660

gatgaggctg attattactg tgcagtgtgg gatgacaccc tgagtggctg ggtgttcggc      720

ggagggacca agctgaccgt ccta                                             744


<210>  61
<211>  744
<212>  DNA
<213>  Homo sapiens

<400>  61
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctgaagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgatgac acggccgtgt attactgtgc gagacggcgc      300

ggcgctaaat ttgactactg gggccaaggg accctggtca ccgtctcctc aaagctttca      360

gggagtgcat ccgccccaaa acttgaagaa ggtgaatttt cagaagcacg cgtatcctat      420

gtgctgactc agccaccctc agcgtctggg acccccgggc agagcgtcac catctcttgt      480

tctggaagca cctccaacat cggaagtcat tatgtggtct ggtaccagca gctcccagga      540

acggccccca gactcctcat ctataggaat catcagcggc cctcaggggt ccctgaccga      600

ctctctggct ccaagtctgg cacctcagcc tccctggcca tcggtgggct ccggtccgag      660

gatgaggctg attattactg tgcagtgtgg gatgacaccc tgagtggctg ggtgttcggc      720

ggagggacca agctgaccgt ccta                                             744


<210>  62
<211>  744
<212>  DNA
<213>  Homo sapiens

<400>  62
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgatgac acggccgtgt attactgtgc gagacggcgc      300

ggcgctaaat ttgactactg gggccaaggg accctggtca ccgtctcctc aaagctttca      360

gggagtgcat ccgccccaaa acttgaagaa ggtgaatttt cagaagcacg cgtatcctat      420

gtgctgactc agcaaccctc agcgtctggg acccccgggc agagcgtcac catctcttgt      480

tctggaagca cctccaacat cggaagtcat tatgtggtct ggtaccagca gctcccagga      540

acggccccca gactcctcat ctataggaat catcagcggc cctcaggggt ccctgaccga      600

ctctctggct ccaagtctgg cacctcagcc tccctggcca tcggtgggct ccggtccgag      660

gatgaggctg attattactg tgcagtgtgg gatgacaccc tgagtggctg ggtgttcggc      720

ggagggacca agctgaccgt ccta                                             744


<210>  63
<211>  744
<212>  DNA
<213>  Homo sapiens

<400>  63
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgatgac acggccgtgt attactgtgc gagacggcgc      300

ggcgctaaat ttgactactg gggccaaggg accctggtca ccgtctcctc aaagctttca      360

gggagtgcat ccgccccaaa acttgaagaa ggtgaatttt cagaagcacg cgtatcctat      420

gtgctgactc agccaccctc agcgtctggg acccccgggc agagcgtcac catctcttgt      480

tctggaagca cctccaacat cggaagtcat tatgtggtct ggtaccagca gctcccagga      540

acggccccca gactcctcat ctataggaat catcagcggc cctcaggggt ccctgaccga      600

ctctctggct ccaagtctgg cacctcagcc tccctggcca tcggtgggct ccggtccgag      660

gatgaggctg attattactg tgcagtgtgg gatgacaccc tgagtggctg ggtgttcggc      720

ggagggacca agctgaccgt ccta                                             744


<210>  64
<211>  744
<212>  DNA
<213>  Homo sapiens

<400>  64
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagacggcgc      300

ggcgctaaat ttgactactg gggccaaggg accctggtca ccgtctcctc aaagctttca      360

gggagtgcat ccgccccaaa acttgaagaa ggtgaatttt cagaagcacg cgtatcctat      420

gtgctgactc agccaccctc agcgtctggg acccccgggc agagcgtcac catctcttgt      480

tctggaagca cctccaacat cggaagtcat tatgtggtct ggtaccagca gctcccagga      540

acggccccca gactcctcat ctataggaat catcagcggc cctcaggggt ccctgaccga      600

ctctctggct ccaagtctgg cacctcagcc tccctggcca tcggtgggct ccggtccgag      660

gatgaggctg attattactg tgcagtgtgg gatgacaccc tgagtggctg ggtgttcggc      720

ggagggacca agctgaccgt ccta                                             744


<210>  65
<211>  1341
<212>  DNA
<213>  Homo sapiens

<400>  65
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgatgac acggccgtgt attactgtgc gagacgcggt      300

gggagctact ttgactactg gggccaaggg accctggtca ccgtctcctc agcctccacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  66
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  66
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtcattatg tgttctggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat aggaatcatc agcggccctc aggggtccct      180

gaccgactct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gtgtgggatg cgaaatacag gggttgggtg      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648


<210>  67
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  67

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Gly Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  68
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  68

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser His 
            20                  25                  30          


Tyr Val Phe Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Ala Lys Tyr 
                85                  90                  95      


Arg Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  69
<211>  1341
<212>  DNA
<213>  Homo sapiens

<400>  69
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag acctgatgac acggccgtgt attactgtgc gagacgcggt      300

gggagctact ttgactactg gggccaaggg accctggtca ccgtctcctc agcctccacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  70
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  70
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtcattatg tgtcctggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat aggaatcatc agcggccctc aggggtccct      180

gaccgactct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gtgtgggatg cgaaatacag gggttgggtg      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648


<210>  71
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  71

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Gly Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  72
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  72

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser His 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Ala Lys Tyr 
                85                  90                  95      


Arg Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  73
<211>  1341
<212>  DNA
<213>  Homo sapiens

<400>  73
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag acctgatgac acggccgtgt attactgtgc gagacgcggt      300

gggagctact ttgactactg gggccaaggg accctggtca ccgtctcctc agcctccacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  74
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  74
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtcattatg tgttctggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat aggaatcatc agcggccctc aggggtccct      180

gaccgactct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gtgtgggatg cgaaatacag gggttgggtg      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648


<210>  75
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  75

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Gly Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  76
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  76

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser His 
            20                  25                  30          


Tyr Val Phe Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Ala Lys Tyr 
                85                  90                  95      


Arg Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  77
<211>  1341
<212>  DNA
<213>  Homo sapiens

<400>  77
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctgaagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgatgac acggccgtgt attactgtgc gagacgcggt      300

gggagctact ttgactactg gggccaaggg accctggtca ccgtctcctc agcctccacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  78
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  78
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtcattatg tgtcctggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat aggaatcatc agcggccctc aggggtccct      180

gaccgactct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gtgtgggatg cgaaatacag gggttgggtg      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648


<210>  79
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  79

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Glu Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Gly Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  80
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  80

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser His 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Ala Lys Tyr 
                85                  90                  95      


Arg Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  81
<211>  1341
<212>  DNA
<213>  Homo sapiens

<400>  81
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctgaagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgatgac acggccgtgt attactgtgc gagacggcgc      300

ggcgctaaat ttgactactg gggccaaggg accctggtca ccgtctcctc agcctccacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  82
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  82
tcctatgtgc tgactcagca accctcagcg tctgggaccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtcattatg tggtctggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat aggaatcatc agcggccctc aggggtccct      180

gaccgactct ctggctccaa gtctggcacc tcagcctccc tggccatcgg tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gtgtgggatg acaccctgag tggctgggtg      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648


<210>  83
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  83

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Glu Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Ala Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  84
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  84

Ser Tyr Val Leu Thr Gln Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser His 
            20                  25                  30          


Tyr Val Val Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Gly Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Asp Thr Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  85
<211>  1341
<212>  DNA
<213>  Homo sapiens

<400>  85
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctgaagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgatgac acggccgtgt attactgtgc gagacggcgc      300

ggcgctaaat ttgactactg gggccaaggg accctggtca ccgtctcctc agcctccacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  86
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  86
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtcattatg tggtctggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat aggaatcatc agcggccctc aggggtccct      180

gaccgactct ctggctccaa gtctggcacc tcagcctccc tggccatcgg tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gtgtgggatg acaccctgag tggctgggtg      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648


<210>  87
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  87

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Glu Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Ala Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  88
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  88

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser His 
            20                  25                  30          


Tyr Val Val Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Gly Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Asp Thr Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  89
<211>  1341
<212>  DNA
<213>  Homo sapiens

<400>  89
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgatgac acggccgtgt attactgtgc gagacggcgc      300

ggcgctaaat ttgactactg gggccaaggg accctggtca ccgtctcctc agcctccacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  90
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  90
tcctatgtgc tgactcagca accctcagcg tctgggaccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtcattatg tggtctggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat aggaatcatc agcggccctc aggggtccct      180

gaccgactct ctggctccaa gtctggcacc tcagcctccc tggccatcgg tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gtgtgggatg acaccctgag tggctgggtg      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648


<210>  91
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  91

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Ala Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  92
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  92

Ser Tyr Val Leu Thr Gln Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser His 
            20                  25                  30          


Tyr Val Val Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Gly Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Asp Thr Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  93
<211>  1341
<212>  DNA
<213>  Homo sapiens

<400>  93
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgatgac acggccgtgt attactgtgc gagacggcgc      300

ggcgctaaat ttgactactg gggccaaggg accctggtca ccgtctcctc agcctccacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  94
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  94
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtcattatg tggtctggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat aggaatcatc agcggccctc aggggtccct      180

gaccgactct ctggctccaa gtctggcacc tcagcctccc tggccatcgg tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gtgtgggatg acaccctgag tggctgggtg      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648


<210>  95
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  95

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Ala Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  96
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  96

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser His 
            20                  25                  30          


Tyr Val Val Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Gly Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Asp Thr Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  97
<211>  1341
<212>  DNA
<213>  Homo sapiens

<400>  97
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagacggcgc      300

ggcgctaaat ttgactactg gggccaaggg accctggtca ccgtctcctc agcctccacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  98
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  98
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtcattatg tggtctggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat aggaatcatc agcggccctc aggggtccct      180

gaccgactct ctggctccaa gtctggcacc tcagcctccc tggccatcgg tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gtgtgggatg acaccctgag tggctgggtg      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648


<210>  99
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  99

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Ala Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  100
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  100

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser His 
            20                  25                  30          


Tyr Val Val Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Gly Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Asp Thr Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  101
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  101
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgatgac acggccgtgt attactgtgc gagacgcggt      300

gggagctact ttgactactg gggccaaggg accctggtca ccgtctcctc a               351


<210>  102
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  102
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtcattatg tgttctggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat aggaatcatc agcggccctc aggggtccct      180

gaccgactct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gtgtgggatg cgaaatacag gggttgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  103
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  103
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag acctgatgac acggccgtgt attactgtgc gagacgcggt      300

gggagctact ttgactactg gggccaaggg accctggtca ccgtctcctc a               351


<210>  104
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  104
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtcattatg tgtcctggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat aggaatcatc agcggccctc aggggtccct      180

gaccgactct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gtgtgggatg cgaaatacag gggttgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  105
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  105
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag acctgatgac acggccgtgt attactgtgc gagacgcggt      300

gggagctact ttgactactg gggccaaggg accctggtca ccgtctcctc a               351


<210>  106
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  106
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtcattatg tgttctggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat aggaatcatc agcggccctc aggggtccct      180

gaccgactct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gtgtgggatg cgaaatacag gggttgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  107
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  107
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctgaagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgatgac acggccgtgt attactgtgc gagacgcggt      300

gggagctact ttgactactg gggccaaggg accctggtca ccgtctcctc a               351


<210>  108
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  108
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtcattatg tgtcctggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat aggaatcatc agcggccctc aggggtccct      180

gaccgactct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gtgtgggatg cgaaatacag gggttgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  109
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  109
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctgaagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgatgac acggccgtgt attactgtgc gagacggcgc      300

ggcgctaaat ttgactactg gggccaaggg accctggtca ccgtctcctc a               351


<210>  110
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  110
tcctatgtgc tgactcagca accctcagcg tctgggaccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtcattatg tggtctggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat aggaatcatc agcggccctc aggggtccct      180

gaccgactct ctggctccaa gtctggcacc tcagcctccc tggccatcgg tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gtgtgggatg acaccctgag tggctgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  111
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  111
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctgaagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgatgac acggccgtgt attactgtgc gagacggcgc      300

ggcgctaaat ttgactactg gggccaaggg accctggtca ccgtctcctc a               351


<210>  112
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  112
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtcattatg tggtctggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat aggaatcatc agcggccctc aggggtccct      180

gaccgactct ctggctccaa gtctggcacc tcagcctccc tggccatcgg tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gtgtgggatg acaccctgag tggctgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  113
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  113
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgatgac acggccgtgt attactgtgc gagacggcgc      300

ggcgctaaat ttgactactg gggccaaggg accctggtca ccgtctcctc a               351


<210>  114
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  114
tcctatgtgc tgactcagca accctcagcg tctgggaccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtcattatg tggtctggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat aggaatcatc agcggccctc aggggtccct      180

gaccgactct ctggctccaa gtctggcacc tcagcctccc tggccatcgg tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gtgtgggatg acaccctgag tggctgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  115
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  115
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tgagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgatgac acggccgtgt attactgtgc gagacggcgc      300

ggcgctaaat ttgactactg gggccaaggg accctggtca ccgtctcctc a               351


<210>  116
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  116
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtcattatg tggtctggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat aggaatcatc agcggccctc aggggtccct      180

gaccgactct ctggctccaa gtctggcacc tcagcctccc tggccatcgg tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gtgtgggatg acaccctgag tggctgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  117
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  117
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagacggcgc      300

ggcgctaaat ttgactactg gggccaaggg accctggtca ccgtctcctc a               351


<210>  118
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  118
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtcattatg tggtctggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat aggaatcatc agcggccctc aggggtccct      180

gaccgactct ctggctccaa gtctggcacc tcagcctccc tggccatcgg tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gtgtgggatg acaccctgag tggctgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  119
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  119

Ser Tyr Ala Xaa Ser 
1               5   


<210>  120
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be M or I

<400>  120

Ser Tyr Ala Xaa Ser 
1               5   


<210>  121
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  VARIANT
<222>  (1)..(17)
<223>  X= any amino acid

<400>  121

Gly Ile Ile Pro Ile Phe Gly Thr Xaa Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  122
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  VARIANT
<222>  (1)..(17)
<223>  X = V, I or A

<400>  122

Gly Ile Ile Pro Ile Phe Gly Thr Xaa Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  123
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  VARIANT
<222>  (1)..(8)
<223>  each X may independently be any amino acid

<400>  123

Arg Xaa Gly Xaa Xaa Phe Asp Tyr 
1               5               


<210>  124
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  X=R or G

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X=S or A

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X= Y or K

<400>  124

Arg Xaa Gly Xaa Xaa Phe Asp Tyr 
1               5               


<210>  125
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  VARIANT
<222>  (1)..(13)
<223>  X = any amino acid

<400>  125

Ser Gly Ser Thr Ser Asn Ile Gly Ser His Tyr Val Xaa 
1               5                   10              


<210>  126
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  VARIANT
<222>  (1)..(13)
<223>  X = F, S or Y

<400>  126

Ser Gly Ser Thr Ser Asn Ile Gly Ser His Tyr Val Xaa 
1               5                   10              


<210>  127
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  VARIANT
<222>  (1)..(11)
<223>  each X may independently be any amino acid

<400>  127

Ala Val Trp Asp Xaa Xaa Xaa Xaa Gly Trp Val 
1               5                   10      


<210>  128
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X= A or D

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X= K or T

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X= Y or L

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  X= R or S

<400>  128

Ala Val Trp Asp Xaa Xaa Xaa Xaa Gly Trp Val 
1               5                   10      


<210>  129
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  homologue


<220>
<221>  VARIANT
<222>  (1)..(22)
<223>  Each X may independently be any amino acid

<400>  129

Xaa Xaa Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  130
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  homologue


<220>
<221>  VARIANT
<222>  (1)..(2)
<223>  X at position 1 = Q and/or X at position 2 = S

<400>  130

Xaa Xaa Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  131
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  homologue


<220>
<221>  VARIANT
<222>  (1)..(22)
<223>  Each X may be any amino acid

<400>  131

Xaa Xaa Val Leu Thr Gln Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  132
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  homologue


<220>
<221>  VARIANT
<222>  (1)..(2)
<223>  X at position 1 = Q and/or X at position 2 = S

<400>  132

Xaa Xaa Val Leu Thr Gln Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  133
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  133
caaagcgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtcattatg tggtctggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat aggaatcatc agcggccctc aggggtccct      180

gaccgactct ctggctccaa gtctggcacc tcagcctccc tggccatcgg tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gtgtgggatg acaccctgag tggctgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


