                               SEQUENCE LISTING	

<110> JOULE UNLIMITED TECHNOLOGIES, INC.
 
<120> METABOLIC SWITCH

<130> 26139-19932 PCT

<140>
<141>

<150> 61/417,105
<151> 2010-11-24

<160> 4     

<170> PatentIn version 3.5

<210> 1
<211> 225
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
gcttgtagca attgctacta aaaactgcga tcgctgctga aatgagctgg aattttgtcc       60

ctctcagctc aaaaagtatc aatgattact taatgtttgt tctgcgcaaa cttcttgcag      120

aacatgcatg atttacaaaa agttgtagtt tctgttacca attgcgaatc gagaactgcc      180

taatctgccg agtatgcgat cctttagcag gaggaaaacc atatg                      225


<210> 2
<211> 725
<212> PRT
<213> Enterococcus faecalis

<400> 2
Met Leu Ala Gln Glu Ser Ile Leu Glu Thr Thr Val Gln Thr Glu Thr 
1               5                   10                  15      


Glu Ser Val Thr Thr Glu Thr Ser Gln Thr Val Ala Asn Leu Glu Ser 
            20                  25                  30          


Glu Thr Thr Ser Gln Thr Val Met Gln Glu Lys Glu Ser Ser Ser Ala 
        35                  40                  45              


Ile Ala Glu Ser Ser Ser Arg Asn Val Val Ala Val Thr Thr Glu Thr 
    50                  55                  60                  


Thr Asn Glu Ile Gln Asn Ser Gly Thr Asp Gly Lys Ala Val Ser Ala 
65                  70                  75                  80  


Glu Ser Val Phe Ser Glu Ala Asp Tyr Lys Gln Ala Thr Ala Leu Glu 
                85                  90                  95      


Leu Ala Thr Leu Val Arg Glu Lys Lys Val Thr Ser Glu Glu Leu Val 
            100                 105                 110         


Lys Ile Ala Leu Ala Ile Thr Lys Arg Glu Asn Pro Thr Leu Asn Ala 
        115                 120                 125             


Val Ile Thr Leu Arg Glu Glu Ala Ala Leu Thr Glu Ala Lys Ala Leu 
    130                 135                 140                 


Gln Asp Thr Gly Gln Pro Phe Leu Gly Val Pro Leu Leu Leu Lys Gly 
145                 150                 155                 160 


Leu Gly Gln Ser Leu Lys Gly Glu Ser Asn Thr Asn Gly Phe Gly Phe 
                165                 170                 175     


Leu Arg Asp Gln Val Ala Gly Gly Thr Ser Thr Phe Val Lys Ala Leu 
            180                 185                 190         


Gln Asn Ala Gly Phe Ile Ile Ile Gly Gln Thr Asn Tyr Pro Glu Leu 
        195                 200                 205             


Gly Trp Lys Asn Ile Ser Asp Ser Lys Leu Tyr Gly Val Ser Val Asn 
    210                 215                 220                 


Pro Trp Asn Pro Asn His Tyr Ser Gly Gly Ser Ser Gly Gly Ala Gly 
225                 230                 235                 240 


Ala Ser Val Ala Ala Ala Phe Val Pro Ile Ala Ser Gly Ser Asp Ala 
                245                 250                 255     


Gly Gly Ser Ile Arg Ile Pro Ala Ser Trp Thr Gly Thr Val Gly Leu 
            260                 265                 270         


Lys Pro Ser Arg Gly Val Ile Ile Gly Asn Ser Asn Ser Ala Lys Gly 
        275                 280                 285             


Gln Thr Val His Phe Gly Leu Ser Arg Thr Val Ala Asp Thr Asn Ala 
    290                 295                 300                 


Leu Phe Glu Thr Leu Leu Thr Lys Lys Asp Leu Pro Ala Gly His Leu 
305                 310                 315                 320 


Ser Gln Ala Gln Pro Ile Ala Tyr Thr Thr Glu Ser Pro Ala Gly Thr 
                325                 330                 335     


Pro Val Ser Ala Glu Ala Lys Glu Ala Val Ala Glu Ala Val Ala Phe 
            340                 345                 350         


Leu Lys Asp Gln Gly Tyr Thr Leu Val Glu Val Lys His Pro Val Asp 
        355                 360                 365             


Gly Glu Arg Leu Met Lys Asn Tyr Tyr Thr Val Ala Ala Gly Ser Ala 
    370                 375                 380                 


Gly Ile Ala Asp Phe Met Ala Arg Gln Lys Leu Lys Arg Pro Leu Glu 
385                 390                 395                 400 


Arg Asn Asp Val Glu Leu Leu Thr Trp Ala Leu Phe Gln Thr Gly Lys 
                405                 410                 415     


Asn Ile Thr Ser Glu Glu Thr Thr Ala Ala Trp Thr Asp Ile Ala Leu 
            420                 425                 430         


Gln Ala Gln Ala Met Asp Glu Phe Tyr Gln Gln Tyr Pro Ile Leu Leu 
        435                 440                 445             


Thr Pro Thr Thr Ala Ala Thr Ala Pro Ser Ile Asp Asn Pro Leu Leu 
    450                 455                 460                 


Lys Pro Glu His Ala Ala Gln Met Glu Lys Ile Asp Gln Leu Ser Pro 
465                 470                 475                 480 


Ala Glu Gln Lys Gln Leu Ile Tyr Asp Gln Trp Leu Thr Ala Phe Thr 
                485                 490                 495     


Tyr Thr Pro Phe Thr Gln Gln Ala Asn Leu Phe Gly His Pro Ala Leu 
            500                 505                 510         


Ser Val Pro Thr Tyr Val Ser Lys Glu Gly Leu Pro Leu Gly Ile Gln 
        515                 520                 525             


Phe Asn Ser Ala Leu Asn Glu Asp Arg Thr Leu Leu Gln Leu Gly Ala 
    530                 535                 540                 


Leu Phe Glu Asn Asn His Lys Ile Asn Gln Pro His Val Glu Glu Pro 
545                 550                 555                 560 


Asp Lys Asp Lys Glu Pro Asp Ala Ser Gly Glu Pro Glu Lys Asp Lys 
                565                 570                 575     


Asp Pro Asn Ala Ser Gly Glu Pro Asp Lys Asp Lys Glu Pro Asp Ala 
            580                 585                 590         


Ser Gly Glu Pro Asp Lys Asp Lys Glu Pro Asp Ala Ser Gly Glu Pro 
        595                 600                 605             


Asp Lys Asp Lys Glu Pro Asp Ala Ser Gly Lys Pro Asp Lys Asp Lys 
    610                 615                 620                 


Glu Thr Lys Thr Ser Glu Gly Pro Ile Glu Gly Lys Asp Gln Asn Gln 
625                 630                 635                 640 


Asn Pro Asp Lys Ala Gly Lys Thr Thr Ser Gly Ser Ser Leu Asp Asn 
                645                 650                 655     


Ser Leu Asn Ser Ser Ala Asn Gln Gly Thr Lys Ser Thr Glu Ser Thr 
            660                 665                 670         


His Ala Phe Ser Asn Lys Ser Met Ile Gly Lys Gln Glu Gln Leu Pro 
        675                 680                 685             


Lys Lys Val Leu Pro Lys Ala Gly Ala Glu Val Pro Ser Thr Phe Trp 
    690                 695                 700                 


Ile Val Leu Gly Gly Ala Phe Leu Val Thr Ser Gly Thr Ile Tyr Ile 
705                 710                 715                 720 


Arg Lys Thr Arg Lys 
                725 


<210> 3
<211> 490
<212> PRT
<213> Enterococcus faecalis

<220>
<223> Sequence is truncated at any one of amino acids at
      positions 450-490

<400> 3
Met Leu Ala Gln Glu Ser Ile Leu Glu Thr Thr Val Gln Thr Glu Thr 
1               5                   10                  15      


Glu Ser Val Thr Thr Glu Thr Ser Gln Thr Val Ala Asn Leu Glu Ser 
            20                  25                  30          


Glu Thr Thr Ser Gln Thr Val Met Gln Glu Lys Glu Ser Ser Ser Ala 
        35                  40                  45              


Ile Ala Glu Ser Ser Ser Arg Asn Val Val Ala Val Thr Thr Glu Thr 
    50                  55                  60                  


Thr Asn Glu Ile Gln Asn Ser Gly Thr Asp Gly Lys Ala Val Ser Ala 
65                  70                  75                  80  


Glu Ser Val Phe Ser Glu Ala Asp Tyr Lys Gln Ala Thr Ala Leu Glu 
                85                  90                  95      


Leu Ala Thr Leu Val Arg Glu Lys Lys Val Thr Ser Glu Glu Leu Val 
            100                 105                 110         


Lys Ile Ala Leu Ala Ile Thr Lys Arg Glu Asn Pro Thr Leu Asn Ala 
        115                 120                 125             


Val Ile Thr Leu Arg Glu Glu Ala Ala Leu Thr Glu Ala Lys Ala Leu 
    130                 135                 140                 


Gln Asp Thr Gly Gln Pro Phe Leu Gly Val Pro Leu Leu Leu Lys Gly 
145                 150                 155                 160 


Leu Gly Gln Ser Leu Lys Gly Glu Ser Asn Thr Asn Gly Phe Gly Phe 
                165                 170                 175     


Leu Arg Asp Gln Val Ala Gly Gly Thr Ser Thr Phe Val Lys Ala Leu 
            180                 185                 190         


Gln Asn Ala Gly Phe Ile Ile Ile Gly Gln Thr Asn Tyr Pro Glu Leu 
        195                 200                 205             


Gly Trp Lys Asn Ile Ser Asp Ser Lys Leu Tyr Gly Val Ser Val Asn 
    210                 215                 220                 


Pro Trp Asn Pro Asn His Tyr Ser Gly Gly Ser Ser Gly Gly Ala Gly 
225                 230                 235                 240 


Ala Ser Val Ala Ala Ala Phe Val Pro Ile Ala Ser Gly Ser Asp Ala 
                245                 250                 255     


Gly Gly Ser Ile Arg Ile Pro Ala Ser Trp Thr Gly Thr Val Gly Leu 
            260                 265                 270         


Lys Pro Ser Arg Gly Val Ile Ile Gly Asn Ser Asn Ser Ala Lys Gly 
        275                 280                 285             


Gln Thr Val His Phe Gly Leu Ser Arg Thr Val Ala Asp Thr Asn Ala 
    290                 295                 300                 


Leu Phe Glu Thr Leu Leu Thr Lys Lys Asp Leu Pro Ala Gly His Leu 
305                 310                 315                 320 


Ser Gln Ala Gln Pro Ile Ala Tyr Thr Thr Glu Ser Pro Ala Gly Thr 
                325                 330                 335     


Pro Val Ser Ala Glu Ala Lys Glu Ala Val Ala Glu Ala Val Ala Phe 
            340                 345                 350         


Leu Lys Asp Gln Gly Tyr Thr Leu Val Glu Val Lys His Pro Val Asp 
        355                 360                 365             


Gly Glu Arg Leu Met Lys Asn Tyr Tyr Thr Val Ala Ala Gly Ser Ala 
    370                 375                 380                 


Gly Ile Ala Asp Phe Met Ala Arg Gln Lys Leu Lys Arg Pro Leu Glu 
385                 390                 395                 400 


Arg Asn Asp Val Glu Leu Leu Thr Trp Ala Leu Phe Gln Thr Gly Lys 
                405                 410                 415     


Asn Ile Thr Ser Glu Glu Thr Thr Ala Ala Trp Thr Asp Ile Ala Leu 
            420                 425                 430         


Gln Ala Gln Ala Met Asp Glu Phe Tyr Gln Gln Tyr Pro Ile Leu Leu 
        435                 440                 445             


Thr Pro Thr Thr Ala Ala Thr Ala Pro Ser Ile Asp Asn Pro Leu Leu 
    450                 455                 460                 


Lys Pro Glu His Ala Ala Gln Met Glu Lys Ile Asp Gln Leu Ser Pro 
465                 470                 475                 480 


Ala Glu Gln Lys Gln Leu Ile Tyr Asp Gln 
                485                 490 


<210> 4
<211> 471
<212> PRT
<213> Enterococcus faecalis

<400> 4
Met Leu Ala Gln Glu Ser Ile Leu Glu Thr Thr Val Gln Thr Glu Thr 
1               5                   10                  15      


Glu Ser Val Thr Thr Glu Thr Ser Gln Thr Val Ala Asn Leu Glu Ser 
            20                  25                  30          


Glu Thr Thr Ser Gln Thr Val Met Gln Glu Lys Glu Ser Ser Ser Ala 
        35                  40                  45              


Ile Ala Glu Ser Ser Ser Arg Asn Val Val Ala Val Thr Thr Glu Thr 
    50                  55                  60                  


Thr Asn Glu Ile Gln Asn Ser Gly Thr Asp Gly Lys Ala Val Ser Ala 
65                  70                  75                  80  


Glu Ser Val Phe Ser Glu Ala Asp Tyr Lys Gln Ala Thr Ala Leu Glu 
                85                  90                  95      


Leu Ala Thr Leu Val Arg Glu Lys Lys Val Thr Ser Glu Glu Leu Val 
            100                 105                 110         


Lys Ile Ala Leu Ala Ile Thr Lys Arg Glu Asn Pro Thr Leu Asn Ala 
        115                 120                 125             


Val Ile Thr Leu Arg Glu Glu Ala Ala Leu Thr Glu Ala Lys Ala Leu 
    130                 135                 140                 


Gln Asp Thr Gly Gln Pro Phe Leu Gly Val Pro Leu Leu Leu Lys Gly 
145                 150                 155                 160 


Leu Gly Gln Ser Leu Lys Gly Glu Ser Asn Thr Asn Gly Phe Gly Phe 
                165                 170                 175     


Leu Arg Asp Gln Val Ala Gly Gly Thr Ser Thr Phe Val Lys Ala Leu 
            180                 185                 190         


Gln Asn Ala Gly Phe Ile Ile Ile Gly Gln Thr Asn Tyr Pro Glu Leu 
        195                 200                 205             


Gly Trp Lys Asn Ile Ser Asp Ser Lys Leu Tyr Gly Val Ser Val Asn 
    210                 215                 220                 


Pro Trp Asn Pro Asn His Tyr Ser Gly Gly Ser Ser Gly Gly Ala Gly 
225                 230                 235                 240 


Ala Ser Val Ala Ala Ala Phe Val Pro Ile Ala Ser Gly Ser Asp Ala 
                245                 250                 255     


Gly Gly Ser Ile Arg Ile Pro Ala Ser Trp Thr Gly Thr Val Gly Leu 
            260                 265                 270         


Lys Pro Ser Arg Gly Val Ile Ile Gly Asn Ser Asn Ser Ala Lys Gly 
        275                 280                 285             


Gln Thr Val His Phe Gly Leu Ser Arg Thr Val Ala Asp Thr Asn Ala 
    290                 295                 300                 


Leu Phe Glu Thr Leu Leu Thr Lys Lys Asp Leu Pro Ala Gly His Leu 
305                 310                 315                 320 


Ser Gln Ala Gln Pro Ile Ala Tyr Thr Thr Glu Ser Pro Ala Gly Thr 
                325                 330                 335     


Pro Val Ser Ala Glu Ala Lys Glu Ala Val Ala Glu Ala Val Ala Phe 
            340                 345                 350         


Leu Lys Asp Gln Gly Tyr Thr Leu Val Glu Val Lys His Pro Val Asp 
        355                 360                 365             


Gly Glu Arg Leu Met Lys Asn Tyr Tyr Thr Val Ala Ala Gly Ser Ala 
    370                 375                 380                 


Gly Ile Ala Asp Phe Met Ala Arg Gln Lys Leu Lys Arg Pro Leu Glu 
385                 390                 395                 400 


Arg Asn Asp Val Glu Leu Leu Thr Trp Ala Leu Phe Gln Thr Gly Lys 
                405                 410                 415     


Asn Ile Thr Ser Glu Glu Thr Thr Ala Ala Trp Thr Asp Ile Ala Leu 
            420                 425                 430         


Gln Ala Gln Ala Met Asp Glu Phe Tyr Gln Gln Tyr Pro Ile Leu Leu 
        435                 440                 445             


Thr Pro Thr Thr Ala Ala Thr Ala Pro Ser Ile Asp Asn Pro Leu Leu 
    450                 455                 460                 


Lys Pro Glu His Ala Ala Gln 
465                 470                



