                         SEQUENCE LISTING

<110>  Technische Universitt Dresden, University of Manchester
 
<120>  Covalently linked interleukin-10

<130>  S2944 PCT

<140>  EP 10 01 5036.6
<141>  2010-11-26

<160>  16    

<170>  PatentIn version 3.4

<210>  1
<211>  160
<212>  PRT
<213>  homo sapiens

<400>  1

Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


<210>  2
<211>  160
<212>  PRT
<213>  mus musculus

<400>  2

Ser Arg Gly Gln Tyr Ser Arg Glu Asp Asn Asn Cys Thr His Phe Pro 
1               5                   10                  15      


Val Gly Gln Ser His Met Leu Leu Glu Leu Arg Thr Ala Phe Ser Gln 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Thr Lys Asp Gln Leu Asp Asn Ile Leu Leu 
        35                  40                  45              


Thr Asp Ser Leu Met Gln Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Val Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Lys His Gly Pro Glu Ile Lys Glu His Leu Asn Ser Leu Gly Glu 
                85                  90                  95      


Lys Leu Lys Thr Leu Arg Met Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Ser Asp Phe 
        115                 120                 125             


Asn Lys Leu Gln Asp Gln Gly Val Tyr Lys Ala Met Asn Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Cys Ile Glu Ala Tyr Met Met Ile Lys Met Lys Ser 
145                 150                 155                 160 


<210>  3
<211>  160
<212>  PRT
<213>  macaca mulatta

<400>  3

Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr Arg Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro His Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Ile Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn His Asp Pro Asp Ile Lys Glu His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Ser Lys Leu Gln Glu Lys Gly Val Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Gln Asn 
145                 150                 155                 160 


<210>  4
<211>  172
<212>  PRT
<213>  Canis lupus familiaris

<400>  4

Met His Gly Ser Ala Leu Leu Cys Cys Cys Leu Val Leu Leu Ala Gly 
1               5                   10                  15      


Val Gly Ala Ser Arg His Gln Ser Thr Leu Leu Glu Asp Asp Pro His 
            20                  25                  30          


Met Leu Arg Glu Leu Arg Ala Ala Phe Gly Arg Val Lys Ile Phe Phe 
        35                  40                  45              


Gln Met Lys Asp Lys Leu Asp Asn Ile Leu Leu Thr Gly Ser Leu Leu 
    50                  55                  60                  


Glu Asp Phe Lys Ser Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile 
65                  70                  75                  80  


Gln Phe Tyr Leu Glu Glu Val Met Pro Arg Ala Glu Asn His Asp Pro 
                85                  90                  95      


Asp Ile Lys Asn His Val Asn Ser Leu Gly Glu Lys Leu Lys Thr Leu 
            100                 105                 110         


Arg Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu 
        115                 120                 125             


Asn Lys Ser Lys Ala Val Glu Gln Val Lys Ser Ala Phe Ser Lys Leu 
    130                 135                 140                 


Gln Glu Lys Gly Val Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile 
145                 150                 155                 160 


Asn Tyr Ile Glu Thr Tyr Met Thr Met Arg Met Lys 
                165                 170         


<210>  5
<211>  178
<212>  PRT
<213>  rattus norvegicus

<400>  5

Met Pro Gly Ser Ala Leu Leu Cys Cys Leu Leu Leu Leu Ala Gly Val 
1               5                   10                  15      


Lys Thr Ser Lys Gly His Ser Ile Arg Gly Asp Asn Asn Cys Thr His 
            20                  25                  30          


Phe Pro Val Ser Gln Thr His Met Leu Arg Glu Leu Arg Ala Ala Phe 
        35                  40                  45              


Ser Gln Val Lys Thr Phe Phe Gln Lys Lys Asp Gln Leu Asp Asn Ile 
    50                  55                  60                  


Leu Leu Thr Asp Ser Leu Leu Gln Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Lys Phe Tyr Leu Val Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn His Gly Pro Glu Ile Lys Glu His Leu Asn Ser Leu 
            100                 105                 110         


Gly Glu Lys Leu Lys Thr Leu Trp Ile Gln Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Asp Phe Asn Lys Leu Gln Asp Lys Gly Val Tyr Lys Ala Met Asn Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Cys Ile Glu Ala Tyr Val Thr Leu Lys Met 
                165                 170                 175     


Lys Asn 
        


<210>  6
<211>  178
<212>  PRT
<213>  cavia porcellus

<400>  6

Met Pro Gly Ser Ala Leu Leu Cys Cys Leu Ala Leu Leu Ala Gly Val 
1               5                   10                  15      


Lys Ala Ser Gln Gly Thr Asn Thr Gln Ser Glu Asp Ser Cys Ala His 
            20                  25                  30          


Phe Pro Ala Gly Leu Pro His Met Leu Arg Glu Leu Arg Ala Ala Phe 
        35                  40                  45              


Gly Arg Val Lys Thr Phe Phe Gln Thr Gln Asp Gln Leu Asp Asn Val 
    50                  55                  60                  


Leu Leu Asn Lys Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Val Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Lys His Gly Pro Glu Ile Lys Glu His Leu Asn Ser Leu 
            100                 105                 110         


Gly Glu Lys Leu Lys Thr Leu Arg Met Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Ser 
    130                 135                 140                 


Asp Phe Asn Lys Leu Gln Asp Gln Gly Val Tyr Lys Ala Met Asn Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Cys Ile Glu Ala Tyr Met Met Ile Lys Met 
                165                 170                 175     


Lys Ser 
        


<210>  7
<211>  175
<212>  PRT
<213>  sus scrofa

<400>  7

Met Pro Ser Ser Ala Leu Leu Tyr Cys Leu Ile Phe Leu Ala Gly Val 
1               5                   10                  15      


Ala Ala Ser Ile Lys Ser Glu Asn Ser Cys Ile His Phe Pro Thr Ser 
            20                  25                  30          


Leu Pro His Met Leu Arg Glu Leu Arg Ala Ala Phe Gly Pro Val Lys 
        35                  40                  45              


Ser Phe Phe Gln Thr Lys Asp Gln Met Gly Asp Leu Leu Leu Thr Gly 
    50                  55                  60                  


Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser 
65                  70                  75                  80  


Glu Met Ile Gln Phe Tyr Leu Glu Asp Val Met Pro Lys Ala Glu Ser 
                85                  90                  95      


Asp Gly Glu Asp Ile Lys Glu His Val Asn Ser Leu Gly Glu Lys Leu 
            100                 105                 110         


Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Gln Phe Leu Pro Cys 
        115                 120                 125             


Glu Asn Lys Ser Lys Ala Val Glu Glu Val Lys Ser Ala Phe Ser Lys 
    130                 135                 140                 


Leu Gln Glu Arg Gly Val Tyr Lys Ala Met Gly Glu Phe Asp Ile Phe 
145                 150                 155                 160 


Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Met Arg Lys Asn 
                165                 170                 175 


<210>  8
<211>  178
<212>  PRT
<213>  homo sapiens

<400>  8

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  9
<211>  178
<212>  PRT
<213>  mus musculus

<400>  9

Met Pro Gly Ser Ala Leu Leu Cys Cys Leu Leu Leu Leu Thr Gly Met 
1               5                   10                  15      


Arg Ile Ser Arg Gly Gln Tyr Ser Arg Glu Asp Asn Asn Cys Thr His 
            20                  25                  30          


Phe Pro Val Gly Gln Ser His Met Leu Leu Glu Leu Arg Thr Ala Phe 
        35                  40                  45              


Ser Gln Val Lys Thr Phe Phe Gln Thr Lys Asp Gln Leu Asp Asn Ile 
    50                  55                  60                  


Leu Leu Thr Asp Ser Leu Met Gln Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Val Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Lys His Gly Pro Glu Ile Lys Glu His Leu Asn Ser Leu 
            100                 105                 110         


Gly Glu Lys Leu Lys Thr Leu Arg Met Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Ser 
    130                 135                 140                 


Asp Phe Asn Lys Leu Gln Asp Gln Gly Val Tyr Lys Ala Met Asn Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Cys Ile Glu Ala Tyr Met Met Ile Lys Met 
                165                 170                 175     


Lys Ser 
        


<210>  10
<211>  178
<212>  PRT
<213>  macaca mulatta

<400>  10

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr Arg 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro His Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Ile 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn His Asp Pro Asp Ile Lys Glu His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Ser Lys Leu Gln Glu Lys Gly Val Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Gln Asn 
        


<210>  11
<211>  134
<212>  PRT
<213>  homo sapiens

<400>  11

Met Arg Met Leu Leu His Leu Ser Leu Leu Ala Leu Gly Ala Ala Tyr 
1               5                   10                  15      


Val Tyr Ala Ile Pro Thr Glu Ile Pro Thr Ser Ala Leu Val Lys Glu 
            20                  25                  30          


Thr Leu Ala Leu Leu Ser Thr His Arg Thr Leu Leu Ile Ala Asn Glu 
        35                  40                  45              


Thr Leu Arg Ile Pro Val Pro Val His Lys Asn His Gln Leu Cys Thr 
    50                  55                  60                  


Glu Glu Ile Phe Gln Gly Ile Gly Thr Leu Glu Ser Gln Thr Val Gln 
65                  70                  75                  80  


Gly Gly Thr Val Glu Arg Leu Phe Lys Asn Leu Ser Leu Ile Lys Lys 
                85                  90                  95      


Tyr Ile Asp Gly Gln Lys Lys Lys Cys Gly Glu Glu Arg Arg Arg Val 
            100                 105                 110         


Asn Gln Phe Leu Asp Tyr Leu Gln Glu Phe Leu Gly Val Met Asn Thr 
        115                 120                 125             


Glu Trp Ile Ile Glu Ser 
    130                 


<210>  12
<211>  133
<212>  PRT
<213>  mus musculus

<400>  12

Met Arg Arg Met Leu Leu His Leu Ser Val Leu Thr Leu Ser Cys Val 
1               5                   10                  15      


Trp Ala Thr Ala Met Glu Ile Pro Met Ser Thr Val Val Lys Glu Thr 
            20                  25                  30          


Leu Thr Gln Leu Ser Ala His Arg Ala Leu Leu Thr Ser Asn Glu Thr 
        35                  40                  45              


Met Arg Leu Pro Val Pro Thr His Lys Asn His Gln Leu Cys Ile Gly 
    50                  55                  60                  


Glu Ile Phe Gln Gly Leu Asp Ile Leu Lys Asn Gln Thr Val Arg Gly 
65                  70                  75                  80  


Gly Thr Val Glu Met Leu Phe Gln Asn Leu Ser Leu Ile Lys Lys Tyr 
                85                  90                  95      


Ile Asp Arg Gln Lys Glu Lys Cys Gly Glu Glu Arg Arg Arg Thr Arg 
            100                 105                 110         


Gln Phe Leu Asp Tyr Leu Gln Glu Phe Leu Gly Val Met Ser Thr Glu 
        115                 120                 125             


Trp Ala Met Glu Gly 
    130             


<210>  13
<211>  166
<212>  PRT
<213>  homo sapiens

<400>  13

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210>  14
<211>  155
<212>  PRT
<213>  mus musculus

<400>  14

Met Asn Ala Thr His Cys Ile Leu Ala Leu Gln Leu Phe Leu Met Ala 
1               5                   10                  15      


Val Ser Gly Cys Tyr Cys His Gly Thr Val Ile Glu Ser Leu Glu Ser 
            20                  25                  30          


Leu Asn Asn Tyr Phe Asn Ser Ser Gly Ile Asp Val Glu Glu Lys Ser 
        35                  40                  45              


Leu Phe Leu Asp Ile Trp Arg Asn Trp Gln Lys Asp Gly Asp Met Lys 
    50                  55                  60                  


Ile Leu Gln Ser Gln Ile Ile Ser Phe Tyr Leu Arg Leu Phe Glu Val 
65                  70                  75                  80  


Leu Lys Asp Asn Gln Ala Ile Ser Asn Asn Ile Ser Val Ile Glu Ser 
                85                  90                  95      


His Leu Ile Thr Thr Phe Phe Ser Asn Ser Lys Ala Lys Lys Asp Ala 
            100                 105                 110         


Phe Met Ser Ile Ala Lys Phe Glu Val Asn Asn Pro Gln Val Gln Arg 
        115                 120                 125             


Gln Ala Phe Asn Glu Leu Ile Arg Val Val His Gln Leu Leu Pro Glu 
    130                 135                 140                 


Ser Ser Leu Arg Lys Arg Lys Arg Ser Arg Cys 
145                 150                 155 


<210>  15
<211>  212
<212>  PRT
<213>  homo sapiens

<400>  15

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  16
<211>  211
<212>  PRT
<213>  mus musculus

<400>  16

Met Lys Phe Leu Ser Ala Arg Asp Phe His Pro Val Ala Phe Leu Gly 
1               5                   10                  15      


Leu Met Leu Val Thr Thr Thr Ala Phe Pro Thr Ser Gln Val Arg Arg 
            20                  25                  30          


Gly Asp Phe Thr Glu Asp Thr Thr Pro Asn Arg Pro Val Tyr Thr Thr 
        35                  40                  45              


Ser Gln Val Gly Gly Leu Ile Thr His Val Leu Trp Glu Ile Val Glu 
    50                  55                  60                  


Met Arg Lys Glu Leu Cys Asn Gly Asn Ser Asp Cys Met Asn Asn Asp 
65                  70                  75                  80  


Asp Ala Leu Ala Glu Asn Asn Leu Lys Leu Pro Glu Ile Gln Arg Asn 
                85                  90                  95      


Asp Gly Cys Tyr Gln Thr Gly Tyr Asn Gln Glu Ile Cys Leu Leu Lys 
            100                 105                 110         


Ile Ser Ser Gly Leu Leu Glu Tyr His Ser Tyr Leu Glu Tyr Met Lys 
        115                 120                 125             


Asn Asn Leu Lys Asp Asn Lys Lys Asp Lys Ala Arg Val Leu Gln Arg 
    130                 135                 140                 


Asp Thr Glu Thr Leu Ile His Ile Phe Asn Gln Glu Val Lys Asp Leu 
145                 150                 155                 160 


His Lys Ile Val Leu Pro Thr Pro Ile Ser Asn Ala Leu Leu Thr Asp 
                165                 170                 175     


Lys Leu Glu Ser Gln Lys Glu Trp Leu Arg Thr Lys Thr Ile Gln Phe 
            180                 185                 190         


Ile Leu Lys Ser Leu Glu Glu Phe Leu Lys Val Thr Leu Arg Ser Thr 
        195                 200                 205             


Arg Gln Thr 
    210     


