                         SEQUENCE LISTING

<110>  Pierre Fabre Medicament
 
<120>  NOVEL HOMOGENEOUS HUMANIZED ANTIPROLIFERATION ANTIBODIES

<130>  D29193

<150>  EP 10306286.5
<151>  2010-11-23

<160>  14    

<170>  PatentIn version 3.3

<210>  1
<211>  6
<212>  PRT
<213>  mus musculus

<400>  1

Gln Asp Ile Asn Asn Tyr 
1               5       


<210>  2
<211>  3
<212>  PRT
<213>  mus musculus

<400>  2

Tyr Thr Ser 
1           


<210>  3
<211>  8
<212>  PRT
<213>  mus musculus

<400>  3

Leu Gln Tyr Asp Asn Leu Trp Thr 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  mus musculus

<400>  4

Gly Tyr Ser Phe Thr Asp Tyr Ser 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  mus musculus

<400>  5

Ile Asp Pro Tyr Asn Gly Gly Thr 
1               5               


<210>  6
<211>  9
<212>  PRT
<213>  mus musculus

<400>  6

Ala Arg Gln Thr Asp Tyr Phe Asp Tyr 
1               5                   


<210>  7
<211>  106
<212>  PRT
<213>  mus musculus

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Ala Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Gly Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  8
<211>  116
<212>  PRT
<213>  mus musculus

<400>  8

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Thr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  9
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized light chain

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Phe Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Ala Lys Ala Pro Lys Leu Phe Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  10
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized heavy chain

<400>  10

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Gln Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Gly Gly Thr Arg Tyr Ser Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Thr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  11
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized light chain

<400>  11

Ala Ile Arg Met Thr Gln Ser Pro Phe Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Ala Lys Ala Pro Lys Leu Phe Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  12
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized heavy chain

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Gly Gly Thr Arg Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Thr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  13
<211>  318
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized light chain

<400>  13
gccattagga tgactcagtc ccccttcagc ctcagcgcct cagtcggtga cagagtgact     60

ataacatgta aggcttcaca agacatcaac aactatattg catggtacca gcaaaagcca    120

gccaaagctc ccaaactttt tatccattac acctccacac tgcagagtgg cgttccttcc    180

cggtttagtg gatctggttc tggcaccgat tacaccctga ccatcagctc tctgcagcct    240

gaagatttcg ccacatatta ttgccttcag tacgataatt tgtggacttt cggccagggg    300

accaaggtgg agatcaag                                                  318


<210>  14
<211>  348
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized heavy chain

<400>  14
caggtgcaat tggtacagtc aggcgcggag gtgaagaagc ctggggctag tgttaaagtc     60

tcctgtaaag cctccggata ttccttcact gactactcta tgcattgggt tcgccaggca    120

ccagggcagc ggctggaatg gatggggtac attgatccct acaacggagg cacgcgatat    180

agtcagaagt tccagggtcg ggtgacaatc acagccgata cgtccaccag caccgcctac    240

atggagttga gcagtctcag gtcagaagac acagccgtgt actattgcgc aagacagacc    300

gattatttcg actactgggg ccaaggcact ctcgtgaccg tctctagc                 348

