                         SEQUENCE LISTING

<110>  University of Delaware
       Naik, Ulhas P.
       Naik, Meghna U.
 
<120>  METHODS OF TREATING AND PREVENTING THROMBOTIC DISEASES

<130>  UOD-354WO

<150>  US 61/415,078
<151>  2010-11-18

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  1374
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Thr Glu Ala Asp Glu Gly Ile Thr Phe Ser Val Pro Pro Phe 
1               5                   10                  15      


Ala Pro Ser Gly Phe Cys Thr Ile Pro Glu Gly Gly Ile Cys Arg Arg 
            20                  25                  30          


Gly Gly Ala Ala Ala Val Gly Glu Gly Glu Glu His Gln Leu Pro Pro 
        35                  40                  45              


Pro Pro Pro Gly Ser Phe Trp Asn Val Glu Ser Ala Ala Ala Pro Gly 
    50                  55                  60                  


Ile Gly Cys Pro Ala Ala Thr Ser Ser Ser Ser Ala Thr Arg Gly Arg 
65                  70                  75                  80  


Gly Ser Ser Val Gly Gly Gly Ser Arg Arg Thr Thr Val Ala Tyr Val 
                85                  90                  95      


Ile Asn Glu Ala Ser Gln Gly Gln Leu Val Val Ala Glu Ser Glu Ala 
            100                 105                 110         


Leu Gln Ser Leu Arg Glu Ala Cys Glu Thr Val Gly Ala Thr Leu Glu 
        115                 120                 125             


Thr Leu His Phe Gly Lys Leu Asp Phe Gly Glu Thr Thr Val Leu Asp 
    130                 135                 140                 


Arg Phe Tyr Asn Ala Asp Ile Ala Val Val Glu Met Ser Asp Ala Phe 
145                 150                 155                 160 


Arg Gln Pro Ser Leu Phe Tyr His Leu Gly Val Arg Glu Ser Phe Ser 
                165                 170                 175     


Met Ala Asn Asn Ile Ile Leu Tyr Cys Asp Thr Asn Ser Asp Ser Leu 
            180                 185                 190         


Gln Ser Leu Lys Glu Ile Ile Cys Gln Lys Asn Thr Met Cys Thr Gly 
        195                 200                 205             


Asn Tyr Thr Phe Val Pro Tyr Met Ile Thr Pro His Asn Lys Val Tyr 
    210                 215                 220                 


Cys Cys Asp Ser Ser Phe Met Lys Gly Leu Thr Glu Leu Met Gln Pro 
225                 230                 235                 240 


Asn Phe Glu Leu Leu Leu Gly Pro Ile Cys Leu Pro Leu Val Asp Arg 
                245                 250                 255     


Phe Ile Gln Leu Leu Lys Val Ala Gln Ala Ser Ser Ser Gln Tyr Phe 
            260                 265                 270         


Arg Glu Ser Ile Leu Asn Asp Ile Arg Lys Ala Arg Asn Leu Tyr Thr 
        275                 280                 285             


Gly Lys Glu Leu Ala Ala Glu Leu Ala Arg Ile Arg Gln Arg Val Asp 
    290                 295                 300                 


Asn Ile Glu Val Leu Thr Ala Asp Ile Val Ile Asn Leu Leu Leu Ser 
305                 310                 315                 320 


Tyr Arg Asp Ile Gln Asp Tyr Asp Ser Ile Val Lys Leu Val Glu Thr 
                325                 330                 335     


Leu Glu Lys Leu Pro Thr Phe Asp Leu Ala Ser His His His Val Lys 
            340                 345                 350         


Phe His Tyr Ala Phe Ala Leu Asn Arg Arg Asn Leu Pro Gly Asp Arg 
        355                 360                 365             


Ala Lys Ala Leu Asp Ile Met Ile Pro Met Val Gln Ser Glu Gly Gln 
    370                 375                 380                 


Val Ala Ser Asp Met Tyr Cys Leu Val Gly Arg Ile Tyr Lys Asp Met 
385                 390                 395                 400 


Phe Leu Asp Ser Asn Phe Thr Asp Thr Glu Ser Arg Asp His Gly Ala 
                405                 410                 415     


Ser Trp Phe Lys Lys Ala Phe Glu Ser Glu Pro Thr Leu Gln Ser Gly 
            420                 425                 430         


Ile Asn Tyr Ala Val Leu Leu Leu Ala Ala Gly His Gln Phe Glu Ser 
        435                 440                 445             


Ser Phe Glu Leu Arg Lys Val Gly Val Lys Leu Ser Ser Leu Leu Gly 
    450                 455                 460                 


Lys Lys Gly Asn Leu Glu Lys Leu Gln Ser Tyr Trp Glu Val Gly Phe 
465                 470                 475                 480 


Phe Leu Gly Ala Ser Val Leu Ala Asn Asp His Met Arg Val Ile Gln 
                485                 490                 495     


Ala Ser Glu Lys Leu Phe Lys Leu Lys Thr Pro Ala Trp Tyr Leu Lys 
            500                 505                 510         


Ser Ile Val Glu Thr Ile Leu Ile Tyr Lys His Phe Val Lys Leu Thr 
        515                 520                 525             


Thr Glu Gln Pro Val Ala Lys Gln Glu Leu Val Asp Phe Trp Met Asp 
    530                 535                 540                 


Phe Leu Val Glu Ala Thr Lys Thr Asp Val Thr Val Val Arg Phe Pro 
545                 550                 555                 560 


Val Leu Ile Leu Glu Pro Thr Lys Ile Tyr Gln Pro Ser Tyr Leu Ser 
                565                 570                 575     


Ile Asn Asn Glu Val Glu Glu Lys Thr Ile Ser Ile Trp His Val Leu 
            580                 585                 590         


Pro Asp Asp Lys Lys Gly Ile His Glu Trp Asn Phe Ser Ala Ser Ser 
        595                 600                 605             


Val Arg Gly Val Ser Ile Ser Lys Phe Glu Glu Arg Cys Cys Phe Leu 
    610                 615                 620                 


Tyr Val Leu His Asn Ser Asp Asp Phe Gln Ile Tyr Phe Cys Thr Glu 
625                 630                 635                 640 


Leu His Cys Lys Lys Phe Phe Glu Met Val Asn Thr Ile Thr Glu Glu 
                645                 650                 655     


Lys Gly Arg Ser Thr Glu Glu Gly Asp Cys Glu Ser Asp Leu Leu Glu 
            660                 665                 670         


Tyr Asp Tyr Glu Tyr Asp Glu Asn Gly Asp Arg Val Val Leu Gly Lys 
        675                 680                 685             


Gly Thr Tyr Gly Ile Val Tyr Ala Gly Arg Asp Leu Ser Asn Gln Val 
    690                 695                 700                 


Arg Ile Ala Ile Lys Glu Ile Pro Glu Arg Asp Ser Arg Tyr Ser Gln 
705                 710                 715                 720 


Pro Leu His Glu Glu Ile Ala Leu His Lys His Leu Lys His Lys Asn 
                725                 730                 735     


Ile Val Gln Tyr Leu Gly Ser Phe Ser Glu Asn Gly Phe Ile Lys Ile 
            740                 745                 750         


Phe Met Glu Gln Val Pro Gly Gly Ser Leu Ser Ala Leu Leu Arg Ser 
        755                 760                 765             


Lys Trp Gly Pro Leu Lys Asp Asn Glu Gln Thr Ile Gly Phe Tyr Thr 
    770                 775                 780                 


Lys Gln Ile Leu Glu Gly Leu Lys Tyr Leu His Asp Asn Gln Ile Val 
785                 790                 795                 800 


His Arg Asp Ile Lys Gly Asp Asn Val Leu Ile Asn Thr Tyr Ser Gly 
                805                 810                 815     


Val Leu Lys Ile Ser Asp Phe Gly Thr Ser Lys Arg Leu Ala Gly Ile 
            820                 825                 830         


Asn Pro Cys Thr Glu Thr Phe Thr Gly Thr Leu Gln Tyr Met Ala Pro 
        835                 840                 845             


Glu Ile Ile Asp Lys Gly Pro Arg Gly Tyr Gly Lys Ala Ala Asp Ile 
    850                 855                 860                 


Trp Ser Leu Gly Cys Thr Ile Ile Glu Met Ala Thr Gly Lys Pro Pro 
865                 870                 875                 880 


Phe Tyr Glu Leu Gly Glu Pro Gln Ala Ala Met Phe Lys Val Gly Met 
                885                 890                 895     


Phe Lys Val His Pro Glu Ile Pro Glu Ser Met Ser Ala Glu Ala Lys 
            900                 905                 910         


Ala Phe Ile Leu Lys Cys Phe Glu Pro Asp Pro Asp Lys Arg Ala Cys 
        915                 920                 925             


Ala Asn Asp Leu Leu Val Asp Glu Phe Leu Lys Val Ser Ser Lys Lys 
    930                 935                 940                 


Lys Lys Thr Gln Pro Lys Leu Ser Ala Leu Ser Ala Gly Ser Asn Glu 
945                 950                 955                 960 


Tyr Leu Arg Ser Ile Ser Leu Pro Val Pro Val Leu Val Glu Asp Thr 
                965                 970                 975     


Ser Ser Ser Ser Glu Tyr Gly Ser Val Ser Pro Asp Thr Glu Leu Lys 
            980                 985                 990         


Val Asp Pro Phe Ser Phe Lys Thr  Arg Ala Lys Ser Cys  Gly Glu Arg 
        995                 1000                 1005             


Asp Val  Lys Gly Ile Arg Thr  Leu Phe Leu Gly Ile  Pro Asp Glu 
    1010                 1015                 1020             


Asn Phe  Glu Asp His Ser Ala  Pro Pro Ser Pro Glu  Glu Lys Asp 
    1025                 1030                 1035             


Ser Gly  Phe Phe Met Leu Arg  Lys Asp Ser Glu Arg  Arg Ala Thr 
    1040                 1045                 1050             


Leu His  Arg Ile Leu Thr Glu  Asp Gln Asp Lys Ile  Val Arg Asn 
    1055                 1060                 1065             


Leu Met  Glu Ser Leu Ala Gln  Gly Ala Glu Glu Pro  Lys Leu Lys 
    1070                 1075                 1080             


Trp Glu  His Ile Thr Thr Leu  Ile Ala Ser Leu Arg  Glu Phe Val 
    1085                 1090                 1095             


Arg Ser  Thr Asp Arg Lys Ile  Ile Ala Thr Thr Leu  Ser Lys Leu 
    1100                 1105                 1110             


Lys Leu  Glu Leu Asp Phe Asp  Ser His Gly Ile Ser  Gln Val Gln 
    1115                 1120                 1125             


Val Val  Leu Phe Gly Phe Gln  Asp Ala Val Asn Lys  Val Leu Arg 
    1130                 1135                 1140             


Asn His  Asn Ile Lys Pro His  Trp Met Phe Ala Leu  Asp Ser Ile 
    1145                 1150                 1155             


Ile Arg  Lys Ala Val Gln Thr  Ala Ile Thr Ile Leu  Val Pro Glu 
    1160                 1165                 1170             


Leu Arg  Pro His Phe Ser Leu  Ala Ser Glu Ser Asp  Thr Ala Asp 
    1175                 1180                 1185             


Gln Glu  Asp Leu Asp Val Glu  Asp Asp His Glu Glu  Gln Pro Ser 
    1190                 1195                 1200             


Asn Gln  Thr Val Arg Arg Pro  Gln Ala Val Ile Glu  Asp Ala Val 
    1205                 1210                 1215             


Ala Thr  Ser Gly Val Ser Thr  Leu Ser Ser Thr Val  Ser His Asp 
    1220                 1225                 1230             


Ser Gln  Ser Ala His Arg Ser  Leu Asn Val Gln Leu  Gly Arg Met 
    1235                 1240                 1245             


Lys Ile  Glu Thr Asn Arg Leu  Leu Glu Glu Leu Val  Arg Lys Glu 
    1250                 1255                 1260             


Lys Glu  Leu Gln Ala Leu Leu  His Arg Ala Ile Glu  Glu Lys Asp 
    1265                 1270                 1275             


Gln Glu  Ile Lys His Leu Lys  Leu Lys Ser Gln Pro  Ile Glu Ile 
    1280                 1285                 1290             


Pro Glu  Leu Pro Val Phe His  Leu Asn Ser Ser Gly  Thr Asn Thr 
    1295                 1300                 1305             


Glu Asp  Ser Glu Leu Thr Asp  Trp Leu Arg Val Asn  Gly Ala Asp 
    1310                 1315                 1320             


Glu Asp  Thr Ile Ser Arg Phe  Leu Ala Glu Asp Tyr  Thr Leu Leu 
    1325                 1330                 1335             


Asp Val  Leu Tyr Tyr Val Thr  Arg Asp Asp Leu Lys  Cys Leu Arg 
    1340                 1345                 1350             


Leu Arg  Gly Gly Met Leu Cys  Thr Leu Trp Lys Ala  Ile Ile Asp 
    1355                 1360                 1365             


Phe Arg  Asn Lys Gln Thr 
    1370                 


<210>  2
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Asp Phe Gly Thr Ser Lys Arg Leu Ala Gly Ile Asn Pro Cys Thr 
1               5                   10                  15      


Glu Thr Phe Thr Gly Thr Leu Gln Tyr Met Ala Pro Glu Ile 
            20                  25                  30  


<210>  3
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Glu Tyr Asp Tyr Glu Tyr Asp Glu Asn Gly Asp Arg Val Val Leu 
1               5                   10                  15      


Gly Lys Gly Thr Tyr Gly Ile Val Tyr Ala Gly Arg Asp Leu Ser Asn 
            20                  25                  30          


Gln Val Arg Ile Ala Ile Lys Glu Ile Pro Glu Arg Asp Ser Arg Tyr 
        35                  40                  45              


Ser Gln Pro Leu His Glu Glu Ile Ala Leu His Lys His Leu Lys His 
    50                  55                  60                  


Lys Asn Ile Val Gln Tyr Leu Gly Ser Phe Ser Glu Asn Gly Phe Ile 
65                  70                  75                  80  


Lys Ile Phe Met Glu Gln Val Pro Gly Gly Ser Leu Ser Ala Leu Leu 
                85                  90                  95      


Arg Ser Lys Trp Gly Pro Leu Lys Asp Asn Glu Gln Thr Ile Gly Phe 
            100                 105                 110         


Tyr Thr Lys Gln Ile Leu Glu Gly Leu Lys Tyr Leu His Asp Asn Gln 
        115                 120                 125             


Ile Val His Arg Asp Ile Lys Gly Asp Asn Val Leu Ile Asn Thr Tyr 
    130                 135                 140                 


Ser Gly Val Leu Lys Ile Ser Asp Phe Gly Thr Ser Lys Arg Leu Ala 
145                 150                 155                 160 


Gly Ile Asn Pro Cys Thr Glu Thr Phe Thr Gly Thr Leu Gln Tyr Met 
                165                 170                 175     


Ala Pro Glu Ile Ile Asp Lys Gly Pro Arg Gly Tyr Gly Lys Ala Ala 
            180                 185                 190         


Asp Ile Trp Ser Leu Gly Cys Thr Ile Ile Glu Met Ala Thr Gly Lys 
        195                 200                 205             


Pro Pro Phe Tyr Glu Leu Gly Glu Pro Gln Ala Ala Met Phe Lys Val 
    210                 215                 220                 


Gly Met Phe Lys Val His Pro Glu Ile Pro Glu Ser Met Ser Ala Glu 
225                 230                 235                 240 


Ala Lys Ala Phe Ile Leu Lys Cys Phe Glu Pro Asp Pro Asp Lys Arg 
                245                 250                 255     


Ala Cys Ala Asn Asp Leu Leu Val Asp Glu Phe Leu Lys Val 
            260                 265                 270 


<210>  4
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Gln Ser Glu Gly Gln Val Ala Ser Asp Met Tyr Cys Leu Val Gly 
1               5                   10                  15      


Arg Ile Tyr Lys Asp Met Phe Leu Asp Ser Asn Phe Thr Asp Thr Glu 
            20                  25                  30          


Ser Arg Asp His Gly Ala Ser Trp Phe Lys Lys Ala Phe Glu Ser Glu 
        35                  40                  45              


Pro Thr Leu Gln Ser Gly Ile Asn Tyr Ala Val Leu Leu Leu Ala Ala 
    50                  55                  60                  


Gly His Gln Phe Glu Ser Ser Phe Glu Leu Arg Lys Val Gly Val Lys 
65                  70                  75                  80  


Leu Ser Ser Leu Leu Gly Lys Lys Gly Asn Leu Glu Lys Leu Gln Ser 
                85                  90                  95      


Tyr Trp Glu Val Gly Phe Phe Leu Gly Ala Ser Val Leu Ala Asn Asp 
            100                 105                 110         


His Met Arg Val Ile Gln Ala Ser Glu Lys Leu Phe Lys Leu Lys Thr 
        115                 120                 125             


Pro Ala Trp Tyr Leu Lys Ser Ile Val Glu Thr Ile Leu Ile Tyr Lys 
    130                 135                 140                 


His Phe Val Lys Leu Thr Thr Glu Gln Pro Val Ala Lys Gln Glu Leu 
145                 150                 155                 160 


Val Asp Phe Trp Met Asp Phe Leu Val Glu Ala Thr Lys Thr Asp Val 
                165                 170                 175     


Thr Val Val Arg Phe Pro Val Leu Ile Leu Glu Pro Thr Lys Ile Tyr 
            180                 185                 190         


Gln Pro Ser Tyr Leu Ser Ile Asn Asn Glu Val Glu Glu Lys Thr Ile 
        195                 200                 205             


Ser Ile Trp His Val Leu Pro Asp Asp Lys Lys Gly Ile His Glu Trp 
    210                 215                 220                 


Asn Phe Ser Ala Ser Ser Val Arg Gly Val Ser Ile Ser Lys Phe Glu 
225                 230                 235                 240 


Glu Arg Cys Cys Phe Leu Tyr Val Leu His Asn Ser Asp Asp Phe Gln 
                245                 250                 255     


Ile Tyr Phe Cys Thr Glu Leu His Cys Lys Lys Phe Phe Glu 
            260                 265                 270 


<210>  5
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Phe Gly Ile Ser Gly Tyr Leu Val Asp Ser Val Ala Lys Thr Met 
1               5                   10                  15      


Asp Ala Gly Cys Lys Pro Tyr Met Ala Pro Glu 
            20                  25          


