                         SEQUENCE LISTING

<110>  Hempstead, Barbara L.
       Kim, Taeho
       Deinhardt, Katrin
       Chao, Moses Victor
       Huang, Jianmin       
 
<120>  Methods For Treating Early Stage or Mild Neurological Disorders

<130>  26980

<140>  To be Assigned
<141>  2011-11-17

<150>  61/414,700
<151>  2010-11-17

<160>  9   

<170>  PatentIn version 3.3

<210>  1
<211>  241
<212>  PRT
<213>  Homo sapien

<400>  1

Met Ser Met Leu Phe Tyr Thr Leu Ile Thr Ala Phe Leu Ile Gly Ile 
1               5                   10                  15      


Gln Ala Glu Pro His Ser Glu Ser Asn Val Pro Ala Gly His Thr Ile 
            20                  25                  30          


Pro Gln Val His Trp Thr Lys Leu Gln His Ser Leu Asp Thr Ala Leu 
        35                  40                  45              


Arg Arg Ala Arg Ser Ala Pro Ala Ala Ala Ile Ala Ala Arg Val Ala 
    50                  55                  60                  


Gly Gln Thr Arg Asn Ile Thr Val Asp Pro Arg Leu Phe Lys Lys Arg 
65                  70                  75                  80  


Arg Leu Arg Ser Pro Arg Val Leu Phe Ser Thr Gln Pro Pro Arg Glu 
                85                  90                  95      


Ala Ala Asp Thr Gln Asp Leu Asp Phe Glu Val Gly Gly Ala Ala Pro 
            100                 105                 110         


Phe Asn Arg Thr His Arg Ser Lys Arg Ser Ser Ser His Pro Ile Phe 
        115                 120                 125             


His Arg Gly Glu Phe Ser Val Cys Asp Ser Val Ser Val Trp Val Gly 
    130                 135                 140                 


Asp Lys Thr Thr Ala Thr Asp Ile Lys Gly Lys Glu Val Met Val Leu 
145                 150                 155                 160 


Gly Glu Val Asn Ile Asn Asn Ser Val Phe Lys Gln Tyr Phe Phe Glu 
                165                 170                 175     


Thr Lys Cys Arg Asp Pro Asn Pro Val Asp Ser Gly Cys Arg Gly Ile 
            180                 185                 190         


Asp Ser Lys His Trp Asn Ser Tyr Cys Thr Thr Thr His Thr Phe Val 
        195                 200                 205             


Lys Ala Leu Thr Met Asp Gly Lys Gln Ala Ala Trp Arg Phe Ile Arg 
    210                 215                 220                 


Ile Asp Thr Ala Cys Val Cys Val Leu Ser Arg Lys Ala Val Arg Arg 
225                 230                 235                 240 


Ala 
    


<210>  2
<211>  247
<212>  PRT
<213>  Homo sapien

<400>  2

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  3
<211>  257
<212>  PRT
<213>  Homo sapien

<400>  3

Met Ser Ile Leu Phe Tyr Val Ile Phe Leu Ala Tyr Leu Arg Gly Ile 
1               5                   10                  15      


Gln Gly Asn Asn Met Asp Gln Arg Ser Leu Pro Glu Asp Ser Leu Asn 
            20                  25                  30          


Ser Leu Ile Ile Lys Leu Ile Gln Ala Asp Ile Leu Lys Asn Lys Leu 
        35                  40                  45              


Ser Lys Gln Met Val Asp Val Lys Glu Asn Tyr Gln Ser Thr Leu Pro 
    50                  55                  60                  


Lys Ala Glu Ala Pro Arg Glu Pro Glu Arg Gly Gly Pro Ala Lys Ser 
65                  70                  75                  80  


Ala Phe Gln Pro Val Ile Ala Met Asp Thr Glu Leu Leu Arg Gln Gln 
                85                  90                  95      


Arg Arg Tyr Asn Ser Pro Arg Val Leu Leu Ser Asp Ser Thr Pro Leu 
            100                 105                 110         


Glu Pro Pro Pro Leu Tyr Leu Met Glu Asp Tyr Val Gly Ser Pro Val 
        115                 120                 125             


Val Ala Asn Arg Thr Ser Arg Arg Lys Arg Tyr Ala Glu His Lys Ser 
    130                 135                 140                 


His Arg Gly Glu Tyr Ser Val Cys Asp Ser Glu Ser Leu Trp Val Thr 
145                 150                 155                 160 


Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly His Gln Val Thr Val Leu 
                165                 170                 175     


Gly Glu Ile Lys Thr Gly Asn Ser Pro Val Lys Gln Tyr Phe Tyr Glu 
            180                 185                 190         


Thr Arg Cys Lys Glu Ala Arg Pro Val Lys Asn Gly Cys Arg Gly Ile 
        195                 200                 205             


Asp Asp Lys His Trp Asn Ser Gln Cys Lys Thr Ser Gln Thr Tyr Val 
    210                 215                 220                 


Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu Val Gly Trp Arg Trp Ile 
225                 230                 235                 240 


Arg Ile Asp Thr Ser Cys Val Cys Ala Leu Ser Arg Lys Ile Gly Arg 
                245                 250                 255     


Thr 
    


<210>  4
<211>  210
<212>  PRT
<213>  Homo sapien

<400>  4

Met Leu Pro Leu Pro Ser Cys Ser Leu Pro Ile Leu Leu Leu Phe Leu 
1               5                   10                  15      


Leu Pro Ser Val Pro Ile Glu Ser Gln Pro Pro Pro Ser Thr Leu Pro 
            20                  25                  30          


Pro Phe Leu Ala Pro Glu Trp Asp Leu Leu Ser Pro Arg Val Val Leu 
        35                  40                  45              


Ser Arg Gly Ala Pro Ala Gly Pro Pro Leu Leu Phe Leu Leu Glu Ala 
    50                  55                  60                  


Gly Ala Phe Arg Glu Ser Ala Gly Ala Pro Ala Asn Arg Ser Arg Arg 
65                  70                  75                  80  


Gly Val Ser Glu Thr Ala Pro Ala Ser Arg Arg Gly Glu Leu Ala Val 
                85                  90                  95      


Cys Asp Ala Val Ser Gly Trp Val Thr Asp Arg Arg Thr Ala Val Asp 
            100                 105                 110         


Leu Arg Gly Arg Glu Val Glu Val Leu Gly Glu Val Pro Ala Ala Gly 
        115                 120                 125             


Gly Ser Pro Leu Arg Gln Tyr Phe Phe Glu Thr Arg Cys Lys Ala Asp 
    130                 135                 140                 


Asn Ala Glu Glu Gly Gly Pro Gly Ala Gly Gly Gly Gly Cys Arg Gly 
145                 150                 155                 160 


Val Asp Arg Arg His Trp Val Ser Glu Cys Lys Ala Lys Gln Ser Tyr 
                165                 170                 175     


Val Arg Ala Leu Thr Ala Asp Ala Gln Gly Arg Val Gly Trp Arg Trp 
            180                 185                 190         


Ile Arg Ile Asp Thr Ala Cys Val Cys Thr Leu Leu Ser Arg Thr Gly 
        195                 200                 205             


Arg Ala 
    210 


 
<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is serine or threonine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is proline or serine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X represents any alpha amino acid.  The number of alpha amino 
       acid can be any number from 0 to approximately 20.

<400>  5

Xaa Xaa Arg Val Xaa
1               5   


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X can be serine or threonine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is proline or serine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is leucine, methionine, or valine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is an alpha amino acid.  The number of alpha amino acids can be
       any number from 0 to approximately 20.

<400>  6

Xaa Xaa Arg Val Xaa Xaa
1               5       


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is serine or threonine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is proline or serine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is leucine, methionine or leucine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is phenylalanine or leucine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is any alpha amino acid.  The number of alpha amino acid can be
       any number from 0 to approximately 20.

<400>  7

Xaa Xaa Arg Val Xaa Xaa Xaa
1               5           


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is serine or threonine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is proline or serine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is leucine, methionine, or valine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is phenylalamine or leucine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is any alpha amino acid.  The number of alpha amino acids can 
       be any number from 0 to approximately 20.

<400>  8

Xaa Xaa Arg Val Xaa Xaa Ser Xaa
1               5               


<210>  9
<211>  1159
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala His Arg Gly Pro Ser Arg Ala Ser Lys Gly Pro Gly Pro Thr 
1               5                   10                  15      


Ala Arg Ala Pro Ser Pro Gly Ala Pro Pro Pro Pro Arg Ser Pro Arg 
            20                  25                  30          


Ser Arg Pro Leu Leu Leu Leu Leu Leu Leu Leu Gly Ala Cys Gly Ala 
        35                  40                  45              


Ala Gly Arg Ser Pro Glu Pro Gly Arg Leu Gly Pro His Ala Gln Leu 
    50                  55                  60                  


Thr Arg Val Pro Arg Ser Pro Pro Ala Gly Arg Ala Glu Pro Gly Gly 
65                  70                  75                  80  


Gly Glu Asp Arg Gln Ala Arg Gly Thr Glu Pro Gly Ala Pro Gly Pro 
                85                  90                  95      


Ser Pro Gly Pro Ala Pro Gly Pro Gly Glu Asp Gly Ala Pro Ala Ala 
            100                 105                 110         


Gly Tyr Arg Arg Trp Glu Arg Ala Ala Pro Leu Ala Gly Val Ala Ser 
        115                 120                 125             


Arg Ala Gln Val Ser Leu Ile Ser Thr Ser Phe Val Leu Lys Gly Asp 
    130                 135                 140                 


Ala Thr His Asn Gln Ala Met Val His Trp Thr Gly Glu Asn Ser Ser 
145                 150                 155                 160 


Val Ile Leu Ile Leu Thr Lys Tyr Tyr His Ala Asp Met Gly Lys Val 
                165                 170                 175     


Leu Glu Ser Ser Leu Trp Arg Ser Ser Asp Phe Gly Thr Ser Tyr Thr 
            180                 185                 190         


Lys Leu Thr Leu Gln Pro Gly Val Thr Thr Val Ile Asp Asn Phe Tyr 
        195                 200                 205             


Ile Cys Pro Thr Asn Lys Arg Lys Val Ile Leu Val Ser Ser Ser Leu 
    210                 215                 220                 


Ser Asp Arg Asp Gln Ser Leu Phe Leu Ser Ala Asp Glu Gly Ala Thr 
225                 230                 235                 240 


Phe Gln Lys Gln Pro Ile Pro Phe Phe Val Glu Thr Leu Ile Phe His 
                245                 250                 255     


Pro Lys Glu Glu Asp Lys Val Leu Ala Tyr Thr Lys Glu Ser Lys Leu 
            260                 265                 270         


Tyr Val Ser Ser Asp Leu Gly Lys Lys Trp Thr Leu Leu Gln Glu Arg 
        275                 280                 285             


Val Thr Lys Asp His Val Phe Trp Ser Val Ser Gly Val Asp Ala Asp 
    290                 295                 300                 


Pro Asp Leu Val His Val Glu Ala Gln Asp Leu Gly Gly Asp Phe Arg 
305                 310                 315                 320 


Tyr Val Thr Cys Ala Ile His Asn Cys Ser Glu Lys Met Leu Thr Ala 
                325                 330                 335     


Pro Phe Ala Gly Pro Ile Asp His Gly Ser Leu Thr Val Gln Asp Asp 
            340                 345                 350         


Tyr Ile Phe Phe Lys Ala Thr Ser Ala Asn Gln Thr Lys Tyr Tyr Val 
        355                 360                 365             


Ser Tyr Arg Arg Asn Glu Phe Val Leu Met Lys Leu Pro Lys Tyr Ala 
    370                 375                 380                 


Leu Pro Lys Asp Leu Gln Ile Ile Ser Thr Asp Glu Ser Gln Val Phe 
385                 390                 395                 400 


Val Ala Val Gln Glu Trp Tyr Gln Met Asp Thr Tyr Asn Leu Tyr Gln 
                405                 410                 415     


Ser Asp Pro Arg Gly Val Arg Tyr Ala Leu Val Leu Gln Asp Val Arg 
            420                 425                 430         


Ser Ser Arg Gln Ala Glu Glu Ser Val Leu Ile Asp Ile Leu Glu Val 
        435                 440                 445             


Arg Gly Val Lys Gly Val Phe Leu Ala Asn Gln Lys Ile Asp Gly Lys 
    450                 455                 460                 


Val Met Thr Leu Ile Thr Tyr Asn Lys Gly Arg Asp Trp Asp Tyr Leu 
465                 470                 475                 480 


Arg Pro Pro Ser Met Asp Met Asn Gly Lys Pro Thr Asn Cys Lys Pro 
                485                 490                 495     


Pro Asp Cys His Leu His Leu His Leu Arg Trp Ala Asp Asn Pro Tyr 
            500                 505                 510         


Val Ser Gly Thr Val His Thr Lys Asp Thr Ala Pro Gly Leu Ile Met 
        515                 520                 525             


Gly Ala Gly Asn Leu Gly Ser Gln Leu Val Glu Tyr Lys Glu Glu Met 
    530                 535                 540                 


Tyr Ile Thr Ser Asp Cys Gly His Thr Trp Arg Gln Val Phe Glu Glu 
545                 550                 555                 560 


Glu His His Ile Leu Tyr Leu Asp His Gly Gly Val Ile Val Ala Ile 
                565                 570                 575     


Lys Asp Thr Ser Ile Pro Leu Lys Ile Leu Lys Phe Ser Val Asp Glu 
            580                 585                 590         


Gly Leu Thr Trp Ser Thr His Asn Phe Thr Ser Thr Ser Val Phe Val 
        595                 600                 605             


Asp Gly Leu Leu Ser Glu Pro Gly Asp Glu Thr Leu Val Met Thr Val 
    610                 615                 620                 


Phe Gly His Ile Ser Phe Arg Ser Asp Trp Glu Leu Val Lys Val Asp 
625                 630                 635                 640 


Phe Arg Pro Ser Phe Ser Arg Gln Cys Gly Glu Glu Asp Tyr Ser Ser 
                645                 650                 655     


Trp Glu Leu Ser Asn Leu Gln Gly Asp Arg Cys Ile Met Gly Gln Gln 
            660                 665                 670         


Arg Ser Phe Arg Lys Arg Lys Ser Thr Ser Trp Cys Ile Lys Gly Arg 
        675                 680                 685             


Ser Phe Thr Ser Ala Leu Thr Ser Arg Val Cys Glu Cys Arg Asp Ser 
    690                 695                 700                 


Asp Phe Leu Cys Asp Tyr Gly Phe Glu Arg Ser Ser Ser Ser Glu Ser 
705                 710                 715                 720 


Ser Thr Asn Lys Cys Ser Ala Asn Phe Trp Phe Asn Pro Leu Ser Pro 
                725                 730                 735     


Pro Asp Asp Cys Ala Leu Gly Gln Thr Tyr Thr Ser Ser Leu Gly Tyr 
            740                 745                 750         


Arg Lys Val Val Ser Asn Val Cys Glu Gly Gly Val Asp Met Gln Gln 
        755                 760                 765             


Ser Gln Val Gln Leu Gln Cys Pro Leu Thr Pro Pro Arg Gly Leu Gln 
    770                 775                 780                 


Val Ser Ile Gln Gly Glu Ala Val Ala Val Arg Pro Gly Glu Asp Val 
785                 790                 795                 800 


Leu Phe Val Val Arg Gln Glu Gln Gly Asp Val Leu Thr Thr Lys Tyr 
                805                 810                 815     


Gln Val Asp Leu Gly Asp Gly Phe Lys Ala Met Tyr Val Asn Leu Thr 
            820                 825                 830         


Leu Thr Gly Glu Pro Ile Arg His Arg Tyr Glu Ser Pro Gly Ile Tyr 
        835                 840                 845             


Arg Val Ser Val Arg Ala Glu Asn Thr Ala Gly His Asp Glu Ala Val 
    850                 855                 860                 


Leu Phe Val Gln Val Asn Ser Pro Leu Gln Ala Leu Tyr Leu Glu Val 
865                 870                 875                 880 


Val Pro Val Ile Gly Leu Asn Gln Glu Val Asn Leu Thr Ala Val Leu 
                885                 890                 895     


Leu Pro Leu Asn Pro Asn Leu Thr Val Phe Tyr Trp Trp Ile Gly His 
            900                 905                 910         


Ser Leu Gln Pro Leu Leu Ser Leu Asp Asn Ser Val Thr Thr Arg Phe 
        915                 920                 925             


Ser Asp Thr Gly Asp Val Arg Val Thr Val Gln Ala Ala Cys Gly Asn 
    930                 935                 940                 


Ser Val Leu Gln Asp Ser Arg Val Leu Arg Val Leu Asp Gln Phe Gln 
945                 950                 955                 960 


Val Met Pro Leu Gln Phe Ser Lys Glu Leu Asp Ala Tyr Asn Pro Asn 
                965                 970                 975     


Thr Pro Glu Trp Arg Glu Asp Val Gly Leu Val Val Thr Arg Leu Leu 
            980                 985                 990         


Ser Lys Glu Thr Ser Val Pro Gln  Glu Leu Leu Val Thr  Val Val Lys 
        995                 1000                 1005             


Pro Gly  Leu Pro Thr Leu Ala  Asp Leu Tyr Val Leu  Leu Pro Pro 
    1010                 1015                 1020             


Pro Arg  Pro Thr Arg Lys Arg  Ser Leu Ser Ser Asp  Lys Arg Leu 
    1025                 1030                 1035             


Ala Ala  Ile Gln Gln Val Leu  Asn Ala Gln Lys Ile  Ser Phe Leu 
    1040                 1045                 1050             


Leu Arg  Gly Gly Val Arg Val  Leu Val Ala Leu Arg  Asp Thr Gly 
    1055                 1060                 1065             


Thr Gly  Ala Glu Gln Leu Gly  Gly Gly Gly Gly Tyr  Trp Ala Val 
    1070                 1075                 1080             


Val Val  Leu Phe Val Ile Gly  Leu Phe Ala Ala Gly  Ala Phe Ile 
    1085                 1090                 1095             


Leu Tyr  Lys Phe Lys Arg Lys  Arg Pro Gly Arg Thr  Val Tyr Ala 
    1100                 1105                 1110             


Gln Met  His Asn Glu Lys Glu  Gln Glu Met Thr Ser  Pro Val Ser 
    1115                 1120                 1125             


His Ser  Glu Asp Val Gln Gly  Ala Val Gln Gly Asn  His Ser Gly 
    1130                 1135                 1140             


Val Val  Leu Ser Ile Asn Ser  Arg Glu Met His Ser  Tyr Leu Val 
    1145                 1150                 1155             


Ser 




