                         SEQUENCE LISTING

<110>  Zhang, Yan
	Tounge, Brett Andrew
	Wang, Aihua
	Hawkins, Michael
	Leonard, Kristi Anne
	Barbay, Joseph Kent
	Maharoof, Umar S.M.


<120>  Pyridyl-Thiazolyl Inhibitors Of Pro-Matrix Metalloproteinase Activation

<130>  PRD3184

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Leu Trp Gln Pro Leu Val Leu Val Leu Leu Val Leu Gly Cys 
1               5                   10                  15      


Cys Phe Ala Ala Pro Arg Gln Arg Gln Ser Thr Leu Val Leu Phe Pro 
            20                  25                  30          


Gly Asp Leu Arg Thr Asn Leu Thr Asp Arg Gln Leu Ala Glu Glu Tyr 
        35                  40                  45              


Leu Tyr Arg Tyr Gly Tyr Thr Arg Val Ala Glu Met Arg Gly Glu Ser 
    50                  55                  60                  


Lys Ser Leu Gly Pro Ala Leu Leu Leu Leu Gln Lys Gln Leu Ser Leu 
65                  70                  75                  80  


Pro Glu Thr Gly Glu Leu Asp Ser Ala Thr Leu Lys Ala Met Arg Thr 
                85                  90                  95      


Pro Arg Cys Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly 
            100                 105                 110         


Asp Leu Lys Trp His His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr 
        115                 120                 125             


Ser Glu Asp Leu Pro Arg Ala Val Ile Asp Asp Ala Phe Ala Arg Ala 
    130                 135                 140                 


Phe Ala Leu Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr 
145                 150                 155                 160 


Ser Arg Asp Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly 
                165                 170                 175     


Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe 
            180                 185                 190         


Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp Glu 
        195                 200                 205             


Leu Trp Ser Leu Gly Lys Gly Val Val Val Pro Thr Arg Phe Gly Asn 
    210                 215                 220                 


Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile Phe Glu Gly Arg Ser 
225                 230                 235                 240 


Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Leu Pro Trp Cys 
                245                 250                 255     


Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg Phe Gly Phe Cys Pro 
            260                 265                 270         


Ser Glu Arg Leu Tyr Thr Gln Asp Gly Asn Ala Asp Gly Lys Pro Cys 
        275                 280                 285             


Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser Tyr Ser Ala Cys Thr Thr 
    290                 295                 300                 


Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn Tyr 
305                 310                 315                 320 


Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro Thr Arg Ala Asp Ser Thr 
                325                 330                 335     


Val Met Gly Gly Asn Ser Ala Gly Glu Leu Cys Val Phe Pro Phe Thr 
            340                 345                 350         


Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr Ser Glu Gly Arg Gly Asp 
        355                 360                 365             


Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Ser Asp Lys Lys 
    370                 375                 380                 


Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala 
385                 390                 395                 400 


His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu 
                405                 410                 415     


Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu Gly Pro Pro Leu His 
            420                 425                 430         


Lys Asp Asp Val Asn Gly Ile Arg His Leu Tyr Gly Pro Arg Pro Glu 
        435                 440                 445             


Pro Glu Pro Arg Pro Pro Thr Thr Thr Thr Pro Gln Pro Thr Ala Pro 
    450                 455                 460                 


Pro Thr Val Cys Pro Thr Gly Pro Pro Thr Val His Pro Ser Glu Arg 
465                 470                 475                 480 


Pro Thr Ala Gly Pro Thr Gly Pro Pro Ser Ala Gly Pro Thr Gly Pro 
                485                 490                 495     


Pro Thr Ala Gly Pro Ser Thr Ala Thr Thr Val Pro Leu Ser Pro Val 
            500                 505                 510         


Asp Asp Ala Cys Asn Val Asn Ile Phe Asp Ala Ile Ala Glu Ile Gly 
        515                 520                 525             


Asn Gln Leu Tyr Leu Phe Lys Asp Gly Lys Tyr Trp Arg Phe Ser Glu 
    530                 535                 540                 


Gly Arg Gly Ser Arg Pro Gln Gly Pro Phe Leu Ile Ala Asp Lys Trp 
545                 550                 555                 560 


Pro Ala Leu Pro Arg Lys Leu Asp Ser Val Phe Glu Glu Pro Leu Ser 
                565                 570                 575     


Lys Lys Leu Phe Phe Phe Ser Gly Arg Gln Val Trp Val Tyr Thr Gly 
            580                 585                 590         


Ala Ser Val Leu Gly Pro Arg Arg Leu Asp Lys Leu Gly Leu Gly Ala 
        595                 600                 605             


Asp Val Ala Gln Val Thr Gly Ala Leu Arg Ser Gly Arg Gly Lys Met 
    610                 615                 620                 


Leu Leu Phe Ser Gly Arg Arg Leu Trp Arg Phe Asp Val Lys Ala Gln 
625                 630                 635                 640 


Met Val Asp Pro Arg Ser Ala Ser Glu Val Asp Arg Met Phe Pro Gly 
                645                 650                 655     


Val Pro Leu Asp Thr His Asp Val Phe Gln Tyr Arg Glu Lys Ala Tyr 
            660                 665                 670         


Phe Cys Gln Asp Arg Phe Tyr Trp Arg Val Ser Ser Arg Ser Glu Leu 
        675                 680                 685             


Asn Gln Val Asp Gln Val Gly Tyr Val Thr Tyr Asp Ile Leu Gln Cys 
    690                 695                 700                 


Pro Glu Asp 
705         


<210>  2
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Pro Arg Gln Arg Gln Ser Thr Leu Val Leu Phe Pro Gly Asp 
1               5                   10                  15      


Leu Arg Thr Asn Leu Thr Asp Arg Gln Leu Ala Glu Glu Tyr Leu Tyr 
            20                  25                  30          


Arg Tyr Gly Tyr Thr Arg Val Ala Glu Met Arg Gly Glu Ser Lys Ser 
        35                  40                  45              


Leu Gly Pro Ala Leu Leu Leu Leu Gln Lys Gln Leu Ser Leu Pro Glu 
    50                  55                  60                  


Thr Gly Glu Leu Asp Ser Ala Thr Leu Lys Ala Met Arg Thr Pro Arg 
65                  70                  75                  80  


Cys Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly Asp Leu 
                85                  90                  95      


Lys Trp His His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr Ser Glu 
            100                 105                 110         


Asp Leu Pro Arg Ala Val Ile Asp Asp Ala Phe Ala Arg Ala Phe Ala 
        115                 120                 125             


Leu Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr Ser Arg 
    130                 135                 140                 


Asp Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly Asp Gly 
145                 150                 155                 160 


Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe Pro Pro 
                165                 170                 175     


Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp Glu Leu Trp 
            180                 185                 190         


Ser Leu Gly Lys Gly Val Val Val Pro Thr Arg Phe Gly Asn Ala Asp 
        195                 200                 205             


Gly Ala Ala Cys His Phe Pro Phe Ile Phe Glu Gly Arg Ser Tyr Ser 
    210                 215                 220                 


Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Leu Pro Trp Cys Ser Thr 
225                 230                 235                 240 


Thr Ala Asn Tyr Asp Thr Asp Asp Arg Phe Gly Phe Cys Pro Ser Glu 
                245                 250                 255     


Arg Leu Tyr Thr Gln Asp Gly Asn Ala Asp Gly Lys Pro Cys Gln Phe 
            260                 265                 270         


Pro Phe Ile Phe Gln Gly Gln Ser Tyr Ser Ala Cys Thr Thr Asp Gly 
        275                 280                 285             


Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn Tyr Asp Arg 
    290                 295                 300                 


Asp Lys Leu Phe Gly Phe Cys Pro Thr Arg Ala Asp Ser Thr Val Met 
305                 310                 315                 320 


Gly Gly Asn Ser Ala Gly Glu Leu Cys Val Phe Pro Phe Thr Phe Leu 
                325                 330                 335     


Gly Lys Glu Tyr Ser Thr Cys Thr Ser Glu Gly Arg Gly Asp Gly Arg 
            340                 345                 350         


Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Ser Asp Lys Lys Trp Gly 
        355                 360                 365             


Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala His Glu 
    370                 375                 380                 


Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu Ala Leu 
385                 390                 395                 400 


Met Tyr Pro Met Tyr Arg Phe Thr Glu Gly Pro Pro Leu His Lys Asp 
                405                 410                 415     


Asp Val Asn Gly Ile Arg His Leu Tyr Gly Pro 
            420                 425         


<210>  3
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Val Leu Phe Pro Gly Asp Leu Arg Thr Asn Leu Thr Asp Arg Gln 
1               5                   10                  15      


Leu Ala Glu Glu Tyr Leu Tyr Arg Tyr Gly Tyr Thr Arg Val Ala Glu 
            20                  25                  30          


Met Arg Gly Glu Ser Lys Ser Leu Gly Pro Ala Leu Leu Leu Leu Gln 
        35                  40                  45              


Lys Gln Leu Ser Leu Pro Glu Thr Gly Glu Leu Asp Ser Ala Thr Leu 
    50                  55                  60                  


Lys Ala Met Arg Thr Pro Arg Cys Gly Val Pro Asp Leu Gly Arg Phe 
65                  70                  75                  80  


Gln Thr Phe Glu Gly Asp Leu Lys Trp His His His Asn Ile Thr Tyr 
                85                  90                  95      


Trp Ile Gln Asn Tyr Ser Glu Asp Leu Pro Arg Ala Val Ile Asp Asp 
            100                 105                 110         


Ala Phe Ala Arg Ala Phe Ala Leu Trp Ser Ala Val Thr Pro Leu Thr 
        115                 120                 125             


Phe Thr Arg Val Tyr Ser Arg Asp Ala Asp Ile Val Ile Gln Phe Gly 
    130                 135                 140                 


Val Ala Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu 
145                 150                 155                 160 


Leu Ala His Ala Phe Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His 
                165                 170                 175     


Phe Asp Asp Asp Glu Leu Trp Ser Leu Gly Lys Gly Val Val Val Pro 
            180                 185                 190         


Thr Arg Phe Gly Asn Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile 
        195                 200                 205             


Phe Glu Gly Arg Ser Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp 
    210                 215                 220                 


Gly Leu Pro Trp Cys Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg 
225                 230                 235                 240 


Phe Gly Phe Cys Pro Ser Glu Arg Leu Tyr Thr Gln Asp Gly Asn Ala 
                245                 250                 255     


Asp Gly Lys Pro Cys Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser Tyr 
            260                 265                 270         


Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala 
        275                 280                 285             


Thr Thr Ala Asn Tyr Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro Thr 
    290                 295                 300                 


Arg Ala Asp Ser Thr Val Met Gly Gly Asn Ser Ala Gly Glu Leu Cys 
305                 310                 315                 320 


Val Phe Pro Phe Thr Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr Ser 
                325                 330                 335     


Glu Gly Arg Gly Asp Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe 
            340                 345                 350         


Asp Ser Asp Lys Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu 
        355                 360                 365             


Phe Leu Val Ala Ala His Glu Phe Gly His Ala Leu Gly Leu Asp His 
    370                 375                 380                 


Ser Ser Val Pro Glu Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu 
385                 390                 395                 400 


Gly Pro Pro Leu His Lys Asp Asp Val Asn Gly Ile Arg His Leu Tyr 
                405                 410                 415     


Gly 
    


<210>  4
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Val Leu Phe Pro Gly Asp Leu Arg Thr Asn Leu Thr Asp Arg Gln 
1               5                   10                  15      


Leu Ala Glu Glu Tyr Leu Tyr Arg Tyr Gly Tyr Thr Arg Val Ala Glu 
            20                  25                  30          


Met Arg Gly Glu Ser Lys Ser Leu Gly Pro Ala Leu Leu Leu Leu Gln 
        35                  40                  45              


Lys Gln Leu Ser Leu Pro Glu Thr Gly Glu Leu Asp Ser Ala Thr Leu 
    50                  55                  60                  


Lys Ala Met Arg Thr Pro Arg Cys Gly Val Pro Asp Leu Gly Arg Phe 
65                  70                  75                  80  


Gln Thr Phe Glu Gly Asp Leu Lys Trp His His His Asn Ile Thr Tyr 
                85                  90                  95      


Trp Ile Gln Asn Tyr Ser Glu Asp Leu Pro Arg Ala Val Ile Asp Asp 
            100                 105                 110         


Ala Phe Ala Arg Ala Phe Ala Leu Trp Ser Ala Val Thr Pro Leu Thr 
        115                 120                 125             


Phe Thr Arg Val Tyr Ser Arg Asp Ala Asp Ile Val Ile Gln Phe Gly 
    130                 135                 140                 


Val Ala Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu 
145                 150                 155                 160 


Leu Ala His Ala Phe Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His 
                165                 170                 175     


Phe Asp Asp Asp Glu Leu Trp Ser Leu Gly Lys Gly Gln Gly Tyr Ser 
            180                 185                 190         


Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ala Leu Gly Leu Asp 
        195                 200                 205             


His Ser Ser Val Pro Glu Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr 
    210                 215                 220                 


Glu Gly Pro Pro Leu His Lys Asp Asp Val Asn Gly Ile Arg His Leu 
225                 230                 235                 240 


Tyr Gly 
        


<210>  5
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Leu Gly Pro Ala Leu Leu Leu Leu Gln Lys Gln Leu Ser Leu Pro 
1               5                   10                  15      


Glu Thr Gly Glu Leu Asp Ser Ala Thr Leu Lys Ala Met Arg Thr Pro 
            20                  25                  30          


Arg Cys Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly Asp 
        35                  40                  45              


Leu Lys Trp His His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr Ser 
    50                  55                  60                  


Glu Asp Leu Pro Arg Ala Val Ile Asp Asp Ala Phe Ala Arg Ala Phe 
65                  70                  75                  80  


Ala Leu Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr Ser 
                85                  90                  95      


Arg Asp Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly Asp 
            100                 105                 110         


Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe Pro 
        115                 120                 125             


Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp Glu Leu 
    130                 135                 140                 


Trp Ser Leu Gly Lys Gly Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala 
145                 150                 155                 160 


His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu 
                165                 170                 175     


Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu Gly Pro Pro Leu His 
            180                 185                 190         


Lys Asp Asp Val Asn Gly Ile Arg His Leu Tyr Gly 
        195                 200                 


<210>  6
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Pro Arg Gln Arg Gln Ser Thr Leu Val Leu Phe Pro Gly Asp 
1               5                   10                  15      


Leu Arg Thr Asn Leu Thr Asp Arg Gln Leu Ala Glu Glu Tyr Leu Tyr 
            20                  25                  30          


Arg Tyr Gly Tyr Thr Arg Val Ala Glu Met Arg Gly Glu Ser Lys Ser 
        35                  40                  45              


Leu Gly Pro Ala Leu Leu Leu Leu Gln Lys Gln Leu Ser Leu Pro Glu 
    50                  55                  60                  


Thr Gly Glu Leu Asp Ser Ala Thr Leu Lys Ala Met Arg Thr Pro Arg 
65                  70                  75                  80  


Cys Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly Asp Leu 
                85                  90                  95      


Lys Trp His His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr Ser Glu 
            100                 105                 110         


Asp Leu Pro Arg Ala Val Ile Asp Asp Ala Phe Ala Arg Ala Phe Ala 
        115                 120                 125             


Leu Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr Ser Arg 
    130                 135                 140                 


Asp Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly Asp Gly 
145                 150                 155                 160 


Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe Pro Pro 
                165                 170                 175     


Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp Glu Leu Trp 
            180                 185                 190         


Ser Leu Gly Lys Gly Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala His 
        195                 200                 205             


Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu Ala 
    210                 215                 220                 


Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu Gly Pro Pro Leu His Lys 
225                 230                 235                 240 


Asp Asp Val Asn Gly Ile Arg His Leu Tyr Gly 
                245                 250     


<210>  7
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  7

Met His Pro Gly Val Leu Ala Ala Phe Leu Phe Leu Ser Trp Thr His 
1               5                   10                  15      


Cys Arg Ala Leu Pro Leu Pro Ser Gly Gly Asp Glu Asp Asp Leu Ser 
            20                  25                  30          


Glu Glu Asp Leu Gln Phe Ala Glu Arg Tyr Leu Arg Ser Tyr Tyr His 
        35                  40                  45              


Pro Thr Asn Leu Ala Gly Ile Leu Lys Glu Asn Ala Ala Ser Ser Met 
    50                  55                  60                  


Thr Glu Arg Leu Arg Glu Met Gln Ser Phe Phe Gly Leu Glu Val Thr 
65                  70                  75                  80  


Gly Lys Leu Asp Asp Asn Thr Leu Asp Val Met Lys Lys Pro Arg Cys 
                85                  90                  95      


Gly Val Pro Asp Val Gly Glu Tyr Asn Val Phe Pro Arg Thr Leu Lys 
            100                 105                 110         


Trp Ser Lys Met Asn Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp 
        115                 120                 125             


Met Thr His Ser Glu Val Glu Lys Ala Phe Lys Lys Ala Phe Lys Val 
    130                 135                 140                 


Trp Ser Asp Val Thr Pro Leu Asn Phe Thr Arg Leu His Asp Gly Ile 
145                 150                 155                 160 


Ala Asp Ile Met Ile Ser Phe Gly Ile Lys Glu His Gly Asp Phe Tyr 
                165                 170                 175     


Pro Phe Asp Gly Pro Ser Gly Leu Leu Ala His Ala Phe Pro Pro Gly 
            180                 185                 190         


Pro Asn Tyr Gly Gly Asp Ala His Phe Asp Asp Asp Glu Thr Trp Thr 
        195                 200                 205             


Ser Ser Ser Lys Gly Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe 
    210                 215                 220                 


Gly His Ser Leu Gly Leu Asp His Ser Lys Asp Pro Gly Ala Leu Met 
225                 230                 235                 240 


Phe Pro Ile Tyr Thr Tyr Thr Gly Lys Ser His Phe Met Leu Pro Asp 
                245                 250                 255     


Asp Asp Val Gln Gly Ile Gln Ser Leu Tyr Gly Pro 
            260                 265             


<210>  8
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Phe Arg Thr Phe Pro Gly Ile Pro Lys Trp Arg Lys Thr His Leu 
1               5                   10                  15      


Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Lys Asp Ala Val 
            20                  25                  30          


Asp Ser Ala Val Glu Lys Ala Leu Lys Val Trp Glu Glu Val Thr Pro 
        35                  40                  45              


Leu Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met Ile Ser 
    50                  55                  60                  


Phe Ala Val Arg Glu His Gly Asp Phe Tyr Pro Phe Asp Gly Pro Gly 
65                  70                  75                  80  


Asn Val Leu Ala His Ala Tyr Ala Pro Gly Pro Gly Ile Asn Gly Asp 
                85                  90                  95      


Ala His Phe Asp Asp Asp Glu Gln Trp Thr Lys Asp Thr Thr Gly Thr 
            100                 105                 110         


Asn Leu Phe Leu Val Ala Ala His Glu Ile Gly His Ser Leu Gly Leu 
        115                 120                 125             


Phe His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr His Ser 
    130                 135                 140                 


Leu Thr Asp Leu Thr Arg Phe Arg Leu Ser Gln Asp Asp Ile Asn Gly 
145                 150                 155                 160 


Ile Gln Ser Leu Tyr Gly Pro 
                165         


<210>  9
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  9

Phe Gln Thr Phe Glu Gly Asp 
1               5           


<210>  10
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  10

Cys Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly Asp 
1               5                   10                  15  


<210>  11
<211>  708
<212>  PRT
<213>  Rattus norvegicus

<400>  11

Met Ser Pro Trp Gln Pro Leu Leu Leu Val Leu Leu Ala Leu Gly Tyr 
1               5                   10                  15      


Ser Phe Ala Ala Pro His Gln Arg Gln Pro Thr Tyr Val Val Phe Pro 
            20                  25                  30          


Arg Asp Leu Lys Thr Ser Asn Leu Thr Asp Thr Gln Leu Ala Glu Asp 
        35                  40                  45              


Tyr Leu Tyr Arg Tyr Gly Tyr Thr Arg Ala Ala Gln Met Met Gly Glu 
    50                  55                  60                  


Lys Gln Ser Leu Arg Pro Ala Leu Leu Met Leu Gln Lys Gln Leu Ser 
65                  70                  75                  80  


Leu Pro Gln Thr Gly Glu Leu Asp Ser Glu Thr Leu Lys Ala Ile Arg 
                85                  90                  95      


Ser Pro Arg Cys Gly Val Pro Asp Val Gly Lys Phe Gln Thr Phe Asp 
            100                 105                 110         


Gly Asp Leu Lys Trp His His His Asn Ile Thr Tyr Trp Ile Gln Ser 
        115                 120                 125             


Tyr Thr Glu Asp Leu Pro Arg Asp Val Ile Asp Asp Ser Phe Ala Arg 
    130                 135                 140                 


Ala Phe Ala Val Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val 
145                 150                 155                 160 


Tyr Gly Leu Glu Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His 
                165                 170                 175     


Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala 
            180                 185                 190         


Phe Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp 
        195                 200                 205             


Glu Leu Trp Ser Leu Gly Lys Gly Ala Val Val Pro Thr Tyr Phe Gly 
    210                 215                 220                 


Asn Ala Asn Gly Ala Pro Cys His Phe Pro Phe Thr Phe Glu Gly Arg 
225                 230                 235                 240 


Ser Tyr Leu Ser Cys Thr Thr Asp Gly Arg Asn Asp Gly Lys Pro Trp 
                245                 250                 255     


Cys Gly Thr Thr Ala Asp Tyr Asp Thr Asp Arg Lys Tyr Gly Phe Cys 
            260                 265                 270         


Pro Ser Glu Asn Leu Tyr Thr Glu His Gly Asn Gly Asp Gly Lys Pro 
        275                 280                 285             


Cys Val Phe Pro Phe Ile Phe Glu Gly His Ser Tyr Ser Ala Cys Thr 
    290                 295                 300                 


Thr Lys Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn 
305                 310                 315                 320 


Tyr Asp Gln Asp Lys Ala Asp Gly Phe Cys Pro Thr Arg Ala Asp Val 
                325                 330                 335     


Thr Val Thr Gly Gly Asn Ser Ala Gly Glu Met Cys Val Phe Pro Phe 
            340                 345                 350         


Val Phe Leu Gly Lys Gln Tyr Ser Thr Cys Thr Ser Glu Gly Arg Ser 
        355                 360                 365             


Asp Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Ala Asp Lys 
    370                 375                 380                 


Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala 
385                 390                 395                 400 


Ala His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro 
                405                 410                 415     


Glu Ala Leu Met Tyr Pro Met Tyr His Tyr His Glu Asp Ser Pro Leu 
            420                 425                 430         


His Glu Asp Asp Ile Lys Gly Ile His His Leu Tyr Gly Arg Gly Ser 
        435                 440                 445             


Lys Pro Asp Pro Arg Pro Pro Ala Thr Thr Ala Ala Glu Pro Gln Pro 
    450                 455                 460                 


Thr Ala Pro Pro Thr Met Cys Ser Thr Ala Pro Pro Met Ala Tyr Pro 
465                 470                 475                 480 


Thr Gly Gly Pro Thr Val Ala Pro Thr Gly Ala Pro Ser Pro Gly Pro 
                485                 490                 495     


Thr Gly Pro Pro Thr Ala Gly Pro Ser Glu Ala Pro Thr Glu Ser Ser 
            500                 505                 510         


Thr Pro Asp Asp Asn Pro Cys Asn Val Asp Val Phe Asp Ala Ile Ala 
        515                 520                 525             


Asp Ile Gln Gly Ala Leu His Phe Phe Lys Asp Gly Arg Tyr Trp Lys 
    530                 535                 540                 


Phe Ser Asn His Gly Gly Asn Gln Leu Gln Gly Pro Phe Leu Ile Ala 
545                 550                 555                 560 


Arg Thr Trp Pro Ala Phe Pro Ser Lys Leu Asn Ser Ala Phe Glu Asp 
                565                 570                 575     


Pro Gln Pro Lys Lys Ile Phe Phe Phe Leu Trp Ala Gln Met Trp Val 
            580                 585                 590         


Tyr Thr Gly Gln Ser Val Leu Gly Pro Arg Ser Leu Asp Lys Leu Gly 
        595                 600                 605             


Leu Gly Ser Glu Val Thr Leu Val Thr Gly Leu Leu Pro Arg Arg Gly 
    610                 615                 620                 


Gly Lys Ala Leu Leu Ile Ser Arg Glu Arg Ile Trp Lys Phe Asp Leu 
625                 630                 635                 640 


Lys Ser Gln Lys Val Asp Pro Gln Ser Val Thr Arg Leu Asp Asn Glu 
                645                 650                 655     


Phe Ser Gly Val Pro Trp Asn Ser His Asn Val Phe Gln Tyr Gln Asp 
            660                 665                 670         


Lys Ala Tyr Phe Cys His Asp Lys Tyr Phe Trp Arg Val Ser Phe His 
        675                 680                 685             


Asn Arg Val Asn Gln Val Asp His Val Ala Tyr Val Thr Tyr Asp Leu 
    690                 695                 700                 


Leu Gln Cys Pro 
705             


