                         SEQUENCE LISTING

<110> Merck Sharp & Dohme Corp.
      Barrett, Stephanie E.
      Busuek, Marina
      Colletti, Steven L.
      Garbaccio, Robert M.
      Guidry, Erin N.
      Kowtoniuk, Robert A.
      Liao, Jing
      Parish, Craig A.
      Parmar, Rubina G.
      Pei, Tao
      Schlosser, Kevin M.
      Tellers, David M.
      Tobias, Sandra C.
      Truong, Quang T.
      Waldman, Jacob H.
      Wang, Weimin
      Williams, J. Michael
 
<120>  Poly(amide) Polymers for the Delivery of Oligonucleotides

<130>  MRL-MIS-00042

<150>  US 61/415,546
<150>  2010-11-19

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted deoxy abasic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted deoxy abasic

<400>  1
cuuuaacaau uccugaaaut t                                                 21


<210>  2
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  phosphorotioate linkage

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  2
auuucaggaa uuguuaaagu u                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  amino linker

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted deoxy abasic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted deoxy abasic

<400>  3
cuagcuggac acgucgauat t                                                 21


<210>  4
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  4
uaucgacgug uccagcuagu u                                                 21


