                         SEQUENCE LISTING

<110>  Exelixis, Inc.
 
<120>  MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLIT

<130>  224990/10-028C-PC/318768

<150>  61/413,954
<151>  2010-11-15

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  1068
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human phosphatidylinositol 3-kinase catalytic subunit alpha 
       polypeptide (PIK3CA) encoded by mRNA polynucleotide sequence ID: 
       NCBI Accession Reference No: NM_006218; GI:54792081 (3724 
       nucleotides)

<400>  1

Met Pro Pro Arg Pro Ser Ser Gly Glu Leu Trp Gly Ile His Leu Met 
1               5                   10                  15      


Pro Pro Arg Ile Leu Val Glu Cys Leu Leu Pro Asn Gly Met Ile Val 
            20                  25                  30          


Thr Leu Glu Cys Leu Arg Glu Ala Thr Leu Ile Thr Ile Lys His Glu 
        35                  40                  45              


Leu Phe Lys Glu Ala Arg Lys Tyr Pro Leu His Gln Leu Leu Gln Asp 
    50                  55                  60                  


Glu Ser Ser Tyr Ile Phe Val Ser Val Thr Gln Glu Ala Glu Arg Glu 
65                  70                  75                  80  


Glu Phe Phe Asp Glu Thr Arg Arg Leu Cys Asp Leu Arg Leu Phe Gln 
                85                  90                  95      


Pro Phe Leu Lys Val Ile Glu Pro Val Gly Asn Arg Glu Glu Lys Ile 
            100                 105                 110         


Leu Asn Arg Glu Ile Gly Phe Ala Ile Gly Met Pro Val Cys Glu Phe 
        115                 120                 125             


Asp Met Val Lys Asp Pro Glu Val Gln Asp Phe Arg Arg Asn Ile Leu 
    130                 135                 140                 


Asn Val Cys Lys Glu Ala Val Asp Leu Arg Asp Leu Asn Ser Pro His 
145                 150                 155                 160 


Ser Arg Ala Met Tyr Val Tyr Pro Pro Asn Val Glu Ser Ser Pro Glu 
                165                 170                 175     


Leu Pro Lys His Ile Tyr Asn Lys Leu Asp Lys Gly Gln Ile Ile Val 
            180                 185                 190         


Val Ile Trp Val Ile Val Ser Pro Asn Asn Asp Lys Gln Lys Tyr Thr 
        195                 200                 205             


Leu Lys Ile Asn His Asp Cys Val Pro Glu Gln Val Ile Ala Glu Ala 
    210                 215                 220                 


Ile Arg Lys Lys Thr Arg Ser Met Leu Leu Ser Ser Glu Gln Leu Lys 
225                 230                 235                 240 


Leu Cys Val Leu Glu Tyr Gln Gly Lys Tyr Ile Leu Lys Val Cys Gly 
                245                 250                 255     


Cys Asp Glu Tyr Phe Leu Glu Lys Tyr Pro Leu Ser Gln Tyr Lys Tyr 
            260                 265                 270         


Ile Arg Ser Cys Ile Met Leu Gly Arg Met Pro Asn Leu Met Leu Met 
        275                 280                 285             


Ala Lys Glu Ser Leu Tyr Ser Gln Leu Pro Met Asp Cys Phe Thr Met 
    290                 295                 300                 


Pro Ser Tyr Ser Arg Arg Ile Ser Thr Ala Thr Pro Tyr Met Asn Gly 
305                 310                 315                 320 


Glu Thr Ser Thr Lys Ser Leu Trp Val Ile Asn Ser Ala Leu Arg Ile 
                325                 330                 335     


Lys Ile Leu Cys Ala Thr Tyr Val Asn Val Asn Ile Arg Asp Ile Asp 
            340                 345                 350         


Lys Ile Tyr Val Arg Thr Gly Ile Tyr His Gly Gly Glu Pro Leu Cys 
        355                 360                 365             


Asp Asn Val Asn Thr Gln Arg Val Pro Cys Ser Asn Pro Arg Trp Asn 
    370                 375                 380                 


Glu Trp Leu Asn Tyr Asp Ile Tyr Ile Pro Asp Leu Pro Arg Ala Ala 
385                 390                 395                 400 


Arg Leu Cys Leu Ser Ile Cys Ser Val Lys Gly Arg Lys Gly Ala Lys 
                405                 410                 415     


Glu Glu His Cys Pro Leu Ala Trp Gly Asn Ile Asn Leu Phe Asp Tyr 
            420                 425                 430         


Thr Asp Thr Leu Val Ser Gly Lys Met Ala Leu Asn Leu Trp Pro Val 
        435                 440                 445             


Pro His Gly Leu Glu Asp Leu Leu Asn Pro Ile Gly Val Thr Gly Ser 
    450                 455                 460                 


Asn Pro Asn Lys Glu Thr Pro Cys Leu Glu Leu Glu Phe Asp Trp Phe 
465                 470                 475                 480 


Ser Ser Val Val Lys Phe Pro Asp Met Ser Val Ile Glu Glu His Ala 
                485                 490                 495     


Asn Trp Ser Val Ser Arg Glu Ala Gly Phe Ser Tyr Ser His Ala Gly 
            500                 505                 510         


Leu Ser Asn Arg Leu Ala Arg Asp Asn Glu Leu Arg Glu Asn Asp Lys 
        515                 520                 525             


Glu Gln Leu Lys Ala Ile Ser Thr Arg Asp Pro Leu Ser Glu Ile Thr 
    530                 535                 540                 


Glu Gln Glu Lys Asp Phe Leu Trp Ser His Arg His Tyr Cys Val Thr 
545                 550                 555                 560 


Ile Pro Glu Ile Leu Pro Lys Leu Leu Leu Ser Val Lys Trp Asn Ser 
                565                 570                 575     


Arg Asp Glu Val Ala Gln Met Tyr Cys Leu Val Lys Asp Trp Pro Pro 
            580                 585                 590         


Ile Lys Pro Glu Gln Ala Met Glu Leu Leu Asp Cys Asn Tyr Pro Asp 
        595                 600                 605             


Pro Met Val Arg Gly Phe Ala Val Arg Cys Leu Glu Lys Tyr Leu Thr 
    610                 615                 620                 


Asp Asp Lys Leu Ser Gln Tyr Leu Ile Gln Leu Val Gln Val Leu Lys 
625                 630                 635                 640 


Tyr Glu Gln Tyr Leu Asp Asn Leu Leu Val Arg Phe Leu Leu Lys Lys 
                645                 650                 655     


Ala Leu Thr Asn Gln Arg Ile Gly His Phe Phe Phe Trp His Leu Lys 
            660                 665                 670         


Ser Glu Met His Asn Lys Thr Val Ser Gln Arg Phe Gly Leu Leu Leu 
        675                 680                 685             


Glu Ser Tyr Cys Arg Ala Cys Gly Met Tyr Leu Lys His Leu Asn Arg 
    690                 695                 700                 


Gln Val Glu Ala Met Glu Lys Leu Ile Asn Leu Thr Asp Ile Leu Lys 
705                 710                 715                 720 


Gln Glu Lys Lys Asp Glu Thr Gln Lys Val Gln Met Lys Phe Leu Val 
                725                 730                 735     


Glu Gln Met Arg Arg Pro Asp Phe Met Asp Ala Leu Gln Gly Phe Leu 
            740                 745                 750         


Ser Pro Leu Asn Pro Ala His Gln Leu Gly Asn Leu Arg Leu Glu Glu 
        755                 760                 765             


Cys Arg Ile Met Ser Ser Ala Lys Arg Pro Leu Trp Leu Asn Trp Glu 
    770                 775                 780                 


Asn Pro Asp Ile Met Ser Glu Leu Leu Phe Gln Asn Asn Glu Ile Ile 
785                 790                 795                 800 


Phe Lys Asn Gly Asp Asp Leu Arg Gln Asp Met Leu Thr Leu Gln Ile 
                805                 810                 815     


Ile Arg Ile Met Glu Asn Ile Trp Gln Asn Gln Gly Leu Asp Leu Arg 
            820                 825                 830         


Met Leu Pro Tyr Gly Cys Leu Ser Ile Gly Asp Cys Val Gly Leu Ile 
        835                 840                 845             


Glu Val Val Arg Asn Ser His Thr Ile Met Gln Ile Gln Cys Lys Gly 
    850                 855                 860                 


Gly Leu Lys Gly Ala Leu Gln Phe Asn Ser His Thr Leu His Gln Trp 
865                 870                 875                 880 


Leu Lys Asp Lys Asn Lys Gly Glu Ile Tyr Asp Ala Ala Ile Asp Leu 
                885                 890                 895     


Phe Thr Arg Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Ile Leu Gly 
            900                 905                 910         


Ile Gly Asp Arg His Asn Ser Asn Ile Met Val Lys Asp Asp Gly Gln 
        915                 920                 925             


Leu Phe His Ile Asp Phe Gly His Phe Leu Asp His Lys Lys Lys Lys 
    930                 935                 940                 


Phe Gly Tyr Lys Arg Glu Arg Val Pro Phe Val Leu Thr Gln Asp Phe 
945                 950                 955                 960 


Leu Ile Val Ile Ser Lys Gly Ala Gln Glu Cys Thr Lys Thr Arg Glu 
                965                 970                 975     


Phe Glu Arg Phe Gln Glu Met Cys Tyr Lys Ala Tyr Leu Ala Ile Arg 
            980                 985                 990         


Gln His Ala Asn Leu Phe Ile Asn  Leu Phe Ser Met Met  Leu Gly Ser 
        995                 1000                 1005             


Gly Met  Pro Glu Leu Gln Ser  Phe Asp Asp Ile Ala  Tyr Ile Arg 
    1010                 1015                 1020             


Lys Thr  Leu Ala Leu Asp Lys  Thr Glu Gln Glu Ala  Leu Glu Tyr 
    1025                 1030                 1035             


Phe Met  Lys Gln Met Asn Asp  Ala His His Gly Gly  Trp Thr Thr 
    1040                 1045                 1050             


Lys Met  Asp Trp Ile Phe His  Thr Ile Lys Gln His  Ala Leu Asn 
    1055                 1060                 1065             


<210>  2
<211>  3724
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human phosphatidylinositol 3-kinase catalytic subunit alpha mRNA 
       polynucleotide sequence ID: NCBI Accession Reference No: 
       NM_006218; GI:54792081 (3724 nucleotides)

<400>  2
tctccctcgg cgccgccgcc gccgcccgcg gggctgggac ccgatgcggt tagagccgcg       60

gagcctggaa gagccccgag cgtttctgct ttgggacaac catacatcta attccttaaa      120

gtagttttat atgtaaaact tgcaaagaat cagaacaatg cctccacgac catcatcagg      180

tgaactgtgg ggcatccact tgatgccccc aagaatccta gtagaatgtt tactaccaaa      240

tggaatgata gtgactttag aatgcctccg tgaggctaca ttaataacca taaagcatga      300

actatttaaa gaagcaagaa aataccccct ccatcaactt cttcaagatg aatcttctta      360

cattttcgta agtgttactc aagaagcaga aagggaagaa ttttttgatg aaacaagacg      420

actttgtgac cttcggcttt ttcaaccctt tttaaaagta attgaaccag taggcaaccg      480

tgaagaaaag atcctcaatc gagaaattgg ttttgctatc ggcatgccag tgtgtgaatt      540

tgatatggtt aaagatccag aagtacagga cttccgaaga aatattctga acgtttgtaa      600

agaagctgtg gatcttaggg acctcaattc acctcatagt agagcaatgt atgtctatcc      660

tccaaatgta gaatcttcac cagaattgcc aaagcacata tataataaat tagataaagg      720

gcaaataata gtggtgatct gggtaatagt ttctccaaat aatgacaagc agaagtatac      780

tctgaaaatc aaccatgact gtgtaccaga acaagtaatt gctgaagcaa tcaggaaaaa      840

aactcgaagt atgttgctat cctctgaaca actaaaactc tgtgttttag aatatcaggg      900

caagtatatt ttaaaagtgt gtggatgtga tgaatacttc ctagaaaaat atcctctgag      960

tcagtataag tatataagaa gctgtataat gcttgggagg atgcccaatt tgatgttgat     1020

ggctaaagaa agcctttatt ctcaactgcc aatggactgt tttacaatgc catcttattc     1080

cagacgcatt tccacagcta caccatatat gaatggagaa acatctacaa aatccctttg     1140

ggttataaat agtgcactca gaataaaaat tctttgtgca acctacgtga atgtaaatat     1200

tcgagacatt gataagatct atgttcgaac aggtatctac catggaggag aacccttatg     1260

tgacaatgtg aacactcaaa gagtaccttg ttccaatccc aggtggaatg aatggctgaa     1320

ttatgatata tacattcctg atcttcctcg tgctgctcga ctttgccttt ccatttgctc     1380

tgttaaaggc cgaaagggtg ctaaagagga acactgtcca ttggcatggg gaaatataaa     1440

cttgtttgat tacacagaca ctctagtatc tggaaaaatg gctttgaatc tttggccagt     1500

acctcatgga ttagaagatt tgctgaaccc tattggtgtt actggatcaa atccaaataa     1560

agaaactcca tgcttagagt tggagtttga ctggttcagc agtgtggtaa agttcccaga     1620

tatgtcagtg attgaagagc atgccaattg gtctgtatcc cgagaagcag gatttagcta     1680

ttcccacgca ggactgagta acagactagc tagagacaat gaattaaggg aaaatgacaa     1740

agaacagctc aaagcaattt ctacacgaga tcctctctct gaaatcactg agcaggagaa     1800

agattttcta tggagtcaca gacactattg tgtaactatc cccgaaattc tacccaaatt     1860

gcttctgtct gttaaatgga attctagaga tgaagtagcc cagatgtatt gcttggtaaa     1920

agattggcct ccaatcaaac ctgaacaggc tatggaactt ctggactgta attacccaga     1980

tcctatggtt cgaggttttg ctgttcggtg cttggaaaaa tatttaacag atgacaaact     2040

ttctcagtat ttaattcagc tagtacaggt cctaaaatat gaacaatatt tggataactt     2100

gcttgtgaga tttttactga agaaagcatt gactaatcaa aggattgggc actttttctt     2160

ttggcattta aaatctgaga tgcacaataa aacagttagc cagaggtttg gcctgctttt     2220

ggagtcctat tgtcgtgcat gtgggatgta tttgaagcac ctgaataggc aagtcgaggc     2280

aatggaaaag ctcattaact taactgacat tctcaaacag gagaagaagg atgaaacaca     2340

aaaggtacag atgaagtttt tagttgagca aatgaggcga ccagatttca tggatgctct     2400

acagggcttt ctgtctcctc taaaccctgc tcatcaacta ggaaacctca ggcttgaaga     2460

gtgtcgaatt atgtcctctg caaaaaggcc actgtggttg aattgggaga acccagacat     2520

catgtcagag ttactgtttc agaacaatga gatcatcttt aaaaatgggg atgatttacg     2580

gcaagatatg ctaacacttc aaattattcg tattatggaa aatatctggc aaaatcaagg     2640

tcttgatctt cgaatgttac cttatggttg tctgtcaatc ggtgactgtg tgggacttat     2700

tgaggtggtg cgaaattctc acactattat gcaaattcag tgcaaaggcg gcttgaaagg     2760

tgcactgcag ttcaacagcc acacactaca tcagtggctc aaagacaaga acaaaggaga     2820

aatatatgat gcagccattg acctgtttac acgttcatgt gctggatact gtgtagctac     2880

cttcattttg ggaattggag atcgtcacaa tagtaacatc atggtgaaag acgatggaca     2940

actgtttcat atagattttg gacacttttt ggatcacaag aagaaaaaat ttggttataa     3000

acgagaacgt gtgccatttg ttttgacaca ggatttctta atagtgatta gtaaaggagc     3060

ccaagaatgc acaaagacaa gagaatttga gaggtttcag gagatgtgtt acaaggctta     3120

tctagctatt cgacagcatg ccaatctctt cataaatctt ttctcaatga tgcttggctc     3180

tggaatgcca gaactacaat cttttgatga cattgcatac attcgaaaga ccctagcctt     3240

agataaaact gagcaagagg ctttggagta tttcatgaaa caaatgaatg atgcacatca     3300

tggtggctgg acaacaaaaa tggattggat cttccacaca attaaacagc atgcattgaa     3360

ctgaaaagat aactgagaaa atgaaagctc actctggatt ccacactgca ctgttaataa     3420

ctctcagcag gcaaagaccg attgcatagg aattgcacaa tccatgaaca gcattagaat     3480

ttacagcaag aacagaaata aaatactata taatttaaat aatgtaaacg caaacagggt     3540

ttgatagcac ttaaactagt tcatttcaaa attaagcttt agaataatgc gcaatttcat     3600

gttatgcctt aagtccaaaa aggtaaactt tgaagattgt ttgtatcttt ttttaaaaaa     3660

caaaacaaaa caaaaatccc caaaatatat agaaatgatg gagaaggaaa aaaaaaaaaa     3720

aaaa                                                                  3724


