
                                SEQUENCE LISTING

<110> MUCKE, LENNART
      CISSE, MOUSTAPHA

<120> Methods of Treating Neurodegenerative
  Disease

<130> GLAD-394WO

<150> 61/413,879          
<151> 2010-11-15  

<160> 4

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 4869
<212> DNA
<213> Homo sapiens

<400> 1
cattctgctg gctgcgcggt ggcggcggct gtgtgtgcgc cgcgccttgc cgccccccct 60
ggccccccga gcccggggcg cgcgctcccg cccgggccgt ccgggccccg cggcgccgcg 120
gcccgaggcc ccgggaagcg cagccatggc tctgcggagg ctgggggccg cgctgctgct 180
gctgccgctg ctcgccgccg tggaagaaac gctaatggac tccactacag cgactgctga 240
gctgggctgg atggtgcatc ctccatcagg gtgggaagag gtgagtggct acgatgagaa 300
catgaacacg atccgcacgt accaggtgtg caacgtgttt gagtcaagcc agaacaactg 360
gctacggacc aagtttatcc ggcgccgtgg cgcccaccgc atccacgtgg agatgaagtt 420
ttcggtgcgt gactgcagca gcatccccag cgtgcctggc tcctgcaagg agaccttcaa 480
cctctattac tatgaggctg actttgactc ggccaccaag accttcccca actggatgga 540
gaatccatgg gtgaaggtgg ataccattgc agccgacgag agcttctccc aggtggacct 600
gggtggccgc gtcatgaaaa tcaacaccga ggtgcggagc ttcggacctg tgtcccgcag 660
cggcttctac ctggccttcc aggactatgg cggctgcatg tccctcatcg ccgtgcgtgt 720
cttctaccgc aagtgccccc gcatcatcca gaatggcgcc atcttccagg aaaccctgtc 780
gggggctgag agcacatcgc tggtggctgc ccggggcagc tgcatcgcca atgcggaaga 840
ggtggatgta cccatcaagc tctactgtaa cggggacggc gagtggctgg tgcccatcgg 900
gcgctgcatg tgcaaagcag gcttcgaggc cgttgagaat ggcaccgtct gccgaggttg 960
tccatctggg actttcaagg ccaaccaagg ggatgaggcc tgtacccact gtcccatcaa 1020
cagccggacc acttctgaag gggccaccaa ctgtgtctgc cgcaatggct actacagagc 1080
agacctggac cccctggaca tgccctgcac aaccatcccc tccgcgcccc aggctgtgat 1140
ttccagtgtc aatgagacct ccctcatgct ggagtggacc cctccccgcg actccggagg 1200
ccgagaggac ctcgtctaca acatcatctg caagagctgt ggctcgggcc ggggtgcctg 1260
cacccgctgc ggggacaatg tacagtacgc accacgccag ctaggcctga ccgagccacg 1320
catttacatc agtgacctgc tggcccacac ccagtacacc ttcgagatcc aggctgtgaa 1380
cggcgttact gaccagagcc ccttctcgcc tcagttcgcc tctgtgaaca tcaccaccaa 1440
ccaggcagct ccatcggcag tgtccatcat gcatcaggtg agccgcaccg tggacagcat 1500
taccctgtcg tggtcccagc cggaccagcc caatggcgtg atcctggact atgagctgca 1560
gtactatgag aaggagctca gtgagtacaa cgccacagcc ataaaaagcc ccaccaacac 1620
ggtcaccgtg cagggcctca aagccggcgc catctatgtc ttccaggtgc gggcacgcac 1680
cgtggcaggc tacgggcgct acagcggcaa gatgtacttc cagaccatga cagaagccga 1740
gtaccagaca agcatccagg agaagttgcc actcatcatc ggctcctcgg ccgctggcct 1800
ggtcttcctc attgctgtgg ttgtcatcgc catcgtgtgt aacagaagac gggggtttga 1860
gcgtgctgac tcggagtaca cggacaagct gcaacactac accagtggcc acatgacccc 1920
aggcatgaag atctacatcg atcctttcac ctacgaggac cccaacgagg cagtgcggga 1980
gtttgccaag gaaattgaca tctcctgtgt caaaattgag caggtgatcg gagcagggga 2040
gtttggcgag gtctgcagtg gccacctgaa gctgccaggc aagagagaga tctttgtggc 2100
catcaagacg ctcaagtcgg gctacacgga gaagcagcgc cgggacttcc tgagcgaagc 2160
ctccatcatg ggccagttcg accatcccaa cgtcatccac ctggagggtg tcgtgaccaa 2220
gagcacacct gtgatgatca tcaccgagtt catggagaat ggctccctgg actcctttct 2280
ccggcaaaac gatgggcagt tcacagtcat ccagctggtg ggcatgcttc ggggcatcgc 2340
agctggcatg aagtacctgg cagacatgaa ctatgttcac cgtgacctgg ctgcccgcaa 2400
catcctcgtc aacagcaacc tggtctgcaa ggtgtcggac tttgggctct cacgctttct 2460
agaggacgat acctcagacc ccacctacac cagtgccctg ggcggaaaga tccccatccg 2520
ctggacagcc ccggaagcca tccagtaccg gaagttcacc tcggccagtg atgtgtggag 2580
ctacggcatt gtcatgtggg aggtgatgtc ctatggggag cggccctact gggacatgac 2640
caaccaggat gtaatcaatg ccattgagca ggactatcgg ctgccaccgc ccatggactg 2700
cccgagcgcc ctgcaccaac tcatgctgga ctgttggcag aaggaccgca accaccggcc 2760
caagttcggc caaattgtca acacgctaga caagatgatc cgcaatccca acagcctcaa 2820
agccatggcg cccctctcct ctggcatcaa cctgccgctg ctggaccgca cgatccccga 2880
ctacaccagc tttaacacgg tggacgagtg gctggaggcc atcaagatgg ggcagtacaa 2940
ggagagcttc gccaatgccg gcttcacctc ctttgacgtc gtgtctcaga tgatgatgga 3000
ggacattctc cgggttgggg tcactttggc tggccaccag aaaaaaatcc tgaacagtat 3060
ccaggtgatg cgggcgcaga tgaaccagat tcagtctgtg gaggtttgac attcacctgc 3120
ctcggctcac ctcttcctcc aagccccgcc ccctctgccc cacgtgccgg ccctcctggt 3180
gctctatcca ctgcagggcc agccactcgc caggaggcca cgggccacgg gaagaaccaa 3240
gcggtgccag ccacgagacg tcaccaagaa aacatgcaac tcaaacgacg gaaaaaaaaa 3300
gggaatggga aaaaagaaaa cagatcctgg gagggggcgg gaaatacaag gaatattttt 3360
taaagaggat tctcataagg aaagcaatga ctgttcttgc gggggataaa aaagggcttg 3420
ggagattcat gcgatgtgtc caatcggaga caaaagcagt ttctctccaa ctccctctgg 3480
gaaggtgacc tggccagagc caagaaacac tttcagaaaa acaaatgtga aggggagaga 3540
caggggccgc ccttggctcc tgtccctgct gctcctctag gcctcactca acaaccaagc 3600
gcctggagga cgggacagat ggacagacag ccaccctgag aacccctctg ggaaaatcta 3660
ttcctgccac cactgggcaa acagaagaat ttttctgtct ttggagagta ttttagaaac 3720
tccaatgaaa gacactgttt ctcctgttgg ctcacagggc tgaaaggggc ttttgtcctc 3780
ctgggtcagg gagaacgcgg ggaccccaga aaggtcagcc ttcctgagga tgggcaaccc 3840
ccaggtctgc agctccaggt acatatcacg cgcacagcct ggcagcctgg ccctcctggt 3900
gcccactccc gccagcccct gcctcgagga ctgatactgc agtgactgcc gtcagctccg 3960
actgccgctg agaagggttg atcctgcatc tgggtttgtt tacagcaatt cctggactcg 4020
ggggtatttt ggtcacaggg tggttttggt ttagggggtt tgtttgttgg gttgtttttt 4080
gttttttggt tttttttaat gacaatgaag tgacactttg acatttccta ccttttgagg 4140
acttgatcct tctccaggaa gaaggtgctt tctgcttact gacttaggca atacaccaag 4200
ggcgagattt tatatgcaca tttctggatt tttttatacg gttttcattg acactcttcc 4260
ctcctcccac ctgccaccag gcctcaccaa agcccactgc catggggcca tctgggccat 4320
tcagagactg gagtgagatt tgggtgtgga gggggaggcg ccaaggtgga ggagcttccc 4380
actccaggac tgttgatgaa agggacagat tgaggaggaa gtgggctctg aggctgcagg 4440
gctggaagtc cttgcccact tcccactctc ctgccccaat ctatctagta cttcccaggc 4500
aaataggccc ctttgaggct cctgagtgcc ctcagatggt caaaacccag ttttccctct 4560
gggagcctaa accaggctgc atcggaggcc aggacccgga tcattcactg tgataccctg 4620
ccctccagag ggtgcgctca gagacacggg caagcatgcc tcttcccttc cctggagaga 4680
aagtgtgtga tttctctccc acctccttcc ccccaccaga cctttgctgg gcctaaaggt 4740
cttggccatg gggacgccct cagtctaggg atctggccac agactccctc ctgtgaacca 4800
acacagacac ccaagcagag caatcagtta gtgaattgaa tggaaataaa cgctttagtt 4860
ataatatga                                                         4869

<210> 2
<211> 987
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Leu Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu
 1               5                  10                  15      
Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu
            20                  25                  30          
Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly
        35                  40                  45              
Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val
    50                  55                  60                  
Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg
65                  70                  75                  80  
Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp
                85                  90                  95      
Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn
            100                 105                 110         
Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro
        115                 120                 125             
Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp
    130                 135                 140                 
Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn
145                 150                 155                 160 
Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu
                165                 170                 175     
Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val
            180                 185                 190         
Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln
        195                 200                 205             
Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly
    210                 215                 220                 
Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr
225                 230                 235                 240 
Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys
                245                 250                 255     
Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys
            260                 265                 270         
Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His
        275                 280                 285             
Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val
    290                 295                 300                 
Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro
305                 310                 315                 320 
Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn
                325                 330                 335     
Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly
            340                 345                 350         
Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly
        355                 360                 365             
Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg
    370                 375                 380                 
Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala
385                 390                 395                 400 
His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp
                405                 410                 415     
Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn
            420                 425                 430         
Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr
        435                 440                 445             
Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly
    450                 455                 460                 
Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu
465                 470                 475                 480 
Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln
                485                 490                 495     
Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr
            500                 505                 510         
Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met
        515                 520                 525             
Thr Glu Ala Glu Tyr Gln Thr Ser Ile Gln Glu Lys Leu Pro Leu Ile
    530                 535                 540                 
Ile Gly Ser Ser Ala Ala Gly Leu Val Phe Leu Ile Ala Val Val Val
545                 550                 555                 560 
Ile Ala Ile Val Cys Asn Arg Arg Arg Gly Phe Glu Arg Ala Asp Ser
                565                 570                 575     
Glu Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro
            580                 585                 590         
Gly Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu
        595                 600                 605             
Ala Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile
    610                 615                 620                 
Glu Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His
625                 630                 635                 640 
Leu Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu
                645                 650                 655     
Lys Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala
            660                 665                 670         
Ser Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly
        675                 680                 685             
Val Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu
    690                 695                 700                 
Asn Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr
705                 710                 715                 720 
Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys
                725                 730                 735     
Tyr Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn
            740                 745                 750         
Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu
        755                 760                 765             
Ser Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala
    770                 775                 780                 
Leu Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln
785                 790                 795                 800 
Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val
                805                 810                 815     
Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr
            820                 825                 830         
Asn Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro
        835                 840                 845             
Pro Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp
    850                 855                 860                 
Gln Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr
865                 870                 875                 880 
Leu Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro
                885                 890                 895     
Leu Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp
            900                 905                 910         
Tyr Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met
        915                 920                 925             
Gly Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp
    930                 935                 940                 
Val Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr
945                 950                 955                 960 
Leu Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg
                965                 970                 975     
Ala Gln Met Asn Gln Ile Gln Ser Val Glu Val
            980                 985         


<210> 3
<211> 986
<212> PRT
<213> Rattus norvegicus

<400> 3
Met Ala Val Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu
 1               5                  10                  15      
Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu
            20                  25                  30          
Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly
        35                  40                  45              
Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val
    50                  55                  60                  
Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg
65                  70                  75                  80  
Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp
                85                  90                  95      
Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn
            100                 105                 110         
Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Leu Ala Thr Lys Thr Phe Pro
        115                 120                 125             
Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp
    130                 135                 140                 
Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn
145                 150                 155                 160 
Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Asn Gly Phe Tyr Leu
                165                 170                 175     
Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val
            180                 185                 190         
Phe Tyr Arg Lys Cys Pro Arg Val Ile Gln Asn Gly Ala Ile Phe Gln
        195                 200                 205             
Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly
    210                 215                 220                 
Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr
225                 230                 235                 240 
Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys
                245                 250                 255     
Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys
            260                 265                 270         
Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His
        275                 280                 285             
Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val
    290                 295                 300                 
Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro
305                 310                 315                 320 
Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn
                325                 330                 335     
Glu Thr Ser Leu Val Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly
            340                 345                 350         
Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly
        355                 360                 365             
Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg
    370                 375                 380                 
Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala
385                 390                 395                 400 
His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp
                405                 410                 415     
Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn
            420                 425                 430         
Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr
        435                 440                 445             
Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly
    450                 455                 460                 
Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu
465                 470                 475                 480 
Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln
                485                 490                 495     
Gly Leu Lys Ala Gly Thr Ile Tyr Val Phe Gln Val Arg Ala Arg Thr
            500                 505                 510         
Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met
        515                 520                 525             
Thr Glu Ala Glu Tyr Gln Thr Ser Ile Lys Glu Lys Leu Pro Leu Ile
    530                 535                 540                 
Val Gly Ser Ser Ala Ala Gly Val Val Phe Val Ile Ala Val Val Val
545                 550                 555                 560 
Ile Ala Ile Val Cys Asn Arg Arg Gly Phe Glu Arg Ala Asp Ser Glu
                565                 570                 575     
Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro Gly
            580                 585                 590         
Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala
        595                 600                 605             
Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile Glu
    610                 615                 620                 
Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His Leu
625                 630                 635                 640 
Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu Lys
                645                 650                 655     
Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser
            660                 665                 670         
Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly Val
        675                 680                 685             
Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn
    690                 695                 700                 
Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val
705                 710                 715                 720 
Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr
                725                 730                 735     
Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile
            740                 745                 750         
Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser
        755                 760                 765             
Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala Leu
    770                 775                 780                 
Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr
785                 790                 795                 800 
Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met
                805                 810                 815     
Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr Asn
            820                 825                 830         
Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro
        835                 840                 845             
Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln
    850                 855                 860                 
Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr Leu
865                 870                 875                 880 
Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro Leu
                885                 890                 895     
Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp Tyr
            900                 905                 910         
Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met Gly
        915                 920                 925             
Gln Tyr Lys Glu Ser Phe Thr Asn Ala Gly Phe Thr Ser Phe Asp Val
    930                 935                 940                 
Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr Leu
945                 950                 955                 960 
Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg Ala
                965                 970                 975     
Gln Met Asn Gln Ile Gln Ser Val Glu Val
            980                 985     


<210> 4
<211> 1012
<212> PRT
<213> Pan troglodytes

<400> 4
Met Glu Asp Leu Ser Cys Leu Gly Leu Gly Leu Cys Glu Gln Asn Leu
 1               5                  10                  15      
Gly Tyr Ile Leu Arg Asp Gly Leu Gly Pro Arg Gly Phe Leu Gln Leu
            20                  25                  30          
Leu Glu Ser Gly Glu Ala Ser Gly Ala Gln Asp Gly Pro Glu Thr Leu
        35                  40                  45              
Met Asp Ser Thr Thr Ala Thr Ala Glu Leu Gly Trp Met Val His Pro
    50                  55                  60                  
Pro Ser Gly Trp Glu Glu Val Ser Gly Tyr Asp Glu Asn Met Asn Thr
65                  70                  75                  80  
Ile Arg Thr Tyr Gln Val Cys Asn Val Phe Glu Ser Ser Gln Asn Asn
                85                  90                  95      
Trp Leu Arg Thr Lys Phe Ile Arg Arg Arg Gly Ala His Arg Ile His
            100                 105                 110         
Val Glu Met Lys Phe Ser Val Arg Asp Cys Ser Ser Ile Pro Ser Val
        115                 120                 125             
Pro Gly Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu Ala Asp
    130                 135                 140                 
Phe Asp Ser Ala Thr Lys Thr Phe Pro Asn Trp Met Glu Asn Pro Trp
145                 150                 155                 160 
Val Lys Val Asp Thr Ile Ala Ala Asp Glu Ser Phe Ser Gln Val Asp
                165                 170                 175     
Leu Gly Gly Arg Val Met Lys Ile Asn Thr Glu Val Arg Ser Phe Gly
            180                 185                 190         
Pro Val Ser Arg Ser Gly Phe Tyr Leu Ala Phe Gln Asp Tyr Gly Gly
        195                 200                 205             
Cys Met Ser Leu Ile Ala Val Arg Val Phe Tyr Arg Lys Cys Pro Arg
    210                 215                 220                 
Ile Ile Gln Asn Gly Ala Ile Phe Gln Glu Thr Leu Ser Gly Ala Glu
225                 230                 235                 240 
Ser Thr Ser Leu Val Ala Ala Arg Gly Ser Cys Ile Ala Asn Ala Glu
                245                 250                 255     
Glu Val Asp Val Pro Ile Lys Leu Tyr Cys Asn Gly Asp Gly Glu Trp
            260                 265                 270         
Leu Val Pro Ile Gly Arg Cys Met Cys Lys Ala Gly Phe Glu Ala Val
        275                 280                 285             
Glu Asn Gly Thr Val Cys Arg Gly Cys Pro Ser Gly Thr Phe Lys Ala
    290                 295                 300                 
Asn Gln Gly Asp Glu Ala Cys Thr His Cys Pro Ile Asn Ser Arg Thr
305                 310                 315                 320 
Thr Ser Glu Gly Ala Thr Asn Cys Val Cys Arg Asn Gly Tyr Tyr Arg
                325                 330                 335     
Ala Asp Leu Asp Pro Leu Asp Met Pro Cys Thr Thr Ile Pro Ser Ala
            340                 345                 350         
Pro Gln Ala Val Ile Ser Ser Val Asn Glu Thr Ser Leu Met Leu Glu
        355                 360                 365             
Trp Thr Pro Pro Arg Asp Ser Gly Gly Arg Glu Asp Leu Val Tyr Asn
    370                 375                 380                 
Ile Ile Cys Lys Ser Cys Gly Ser Gly Arg Gly Ala Cys Thr Arg Cys
385                 390                 395                 400 
Gly Asp Asn Val Gln Tyr Ala Pro Arg Gln Leu Gly Leu Thr Glu Pro
                405                 410                 415     
Arg Ile Tyr Ile Ser Asp Leu Leu Ala His Thr Gln Tyr Thr Phe Glu
            420                 425                 430         
Ile Gln Ala Val Asn Gly Val Thr Asp Gln Ser Pro Phe Ser Pro Gln
        435                 440                 445             
Phe Ala Ser Val Asn Ile Thr Thr Asn Gln Ala Ala Pro Ser Ala Val
    450                 455                 460                 
Ser Ile Met His Gln Val Ser Arg Thr Val Asp Ser Ile Thr Leu Ser
465                 470                 475                 480 
Trp Ser Gln Pro Asp Gln Pro Asn Gly Val Ile Leu Asp Tyr Glu Leu
                485                 490                 495     
Gln Tyr Tyr Glu Lys Glu Leu Ser Glu Tyr Asn Ala Thr Ala Ile Lys
            500                 505                 510         
Ser Pro Thr Asn Thr Val Thr Val Gln Gly Leu Lys Ala Gly Ala Ile
        515                 520                 525             
Tyr Val Phe Gln Val Arg Ala Arg Thr Val Ala Gly Tyr Gly Arg Tyr
    530                 535                 540                 
Ser Gly Lys Met Tyr Phe Gln Thr Met Thr Glu Ala Glu Tyr Gln Thr
545                 550                 555                 560 
Ser Ile Gln Glu Lys Leu Pro Leu Ile Ile Gly Ser Ser Ala Ala Gly
                565                 570                 575     
Leu Val Phe Leu Ile Ala Val Val Val Ile Ala Ile Val Cys Asn Arg
            580                 585                 590         
Arg Arg Gly Phe Glu Arg Ala Asp Ser Glu Tyr Thr Asp Lys Leu Gln
        595                 600                 605             
His Tyr Thr Ser Gly His Met Thr Pro Gly Met Lys Ile Tyr Ile Asp
    610                 615                 620                 
Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe Ala Lys
625                 630                 635                 640 
Glu Ile Asp Ile Ser Cys Val Lys Ile Glu Gln Val Ile Gly Ala Gly
                645                 650                 655     
Glu Phe Gly Glu Val Cys Ser Gly His Leu Lys Leu Pro Gly Lys Arg
            660                 665                 670         
Glu Ile Phe Val Ala Ile Lys Thr Leu Lys Ser Gly Tyr Thr Glu Lys
        675                 680                 685             
Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met Gly Gln Phe Asp
    690                 695                 700                 
His Pro Asn Val Ile His Leu Glu Gly Val Val Thr Lys Ser Thr Pro
705                 710                 715                 720 
Val Met Ile Ile Thr Glu Phe Met Glu Asn Gly Ser Leu Asp Ser Phe
                725                 730                 735     
Leu Arg Gln Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met
            740                 745                 750         
Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala Asp Met Asn Tyr
        755                 760                 765             
Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu
    770                 775                 780                 
Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu Asp Asp
785                 790                 795                 800 
Thr Ser Asp Pro Thr Tyr Thr Ser Ala Leu Gly Gly Lys Ile Pro Ile
                805                 810                 815     
Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr Arg Lys Phe Thr Ser Ala
            820                 825                 830         
Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Tyr
        835                 840                 845             
Gly Glu Arg Pro Tyr Trp Asp Met Thr Asn Gln Asp Val Ile Asn Ala
    850                 855                 860                 
Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp Cys Pro Ser Ala
865                 870                 875                 880 
Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp Arg Asn His Arg
                885                 890                 895     
Pro Lys Phe Gly Gln Ile Val Asn Thr Leu Asp Lys Met Ile Arg Asn
            900                 905                 910         
Pro Asn Ser Leu Lys Ala Met Ala Pro Leu Ser Ser Gly Ile Asn Leu
        915                 920                 925             
Pro Leu Leu Asp Arg Thr Ile Pro Asp Tyr Thr Ser Phe Asn Thr Val
    930                 935                 940                 
Asp Glu Trp Leu Glu Ala Ile Lys Met Gly Gln Tyr Lys Glu Ser Phe
945                 950                 955                 960 
Ala Asn Ala Gly Phe Thr Ser Phe Asp Val Val Ser Gln Met Met Met
                965                 970                 975     
Glu Asp Ile Leu Arg Val Gly Val Thr Leu Ala Gly His Gln Lys Lys
            980                 985                 990         
Ile Leu Asn Ser Ile Gln Val Met Arg Ala Gln Met Asn Gln Ile Gln
        995                 1000                1005            
Ser Val Glu Val
    1010        

