                         SEQUENCE LISTING

<110>  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS
 
<120>  Inhibitors of apoptosis and uses thereof

<130>  BCT100293

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  740
<212>  PRT
<213>  homo sapiens

<400>  1

Met Ala Thr Ala Asn Ser Ile Ile Val Leu Asp Asp Asp Asp Glu Asp 
1               5                   10                  15      


Glu Ala Ala Ala Gln Pro Gly Pro Ser His Pro Leu Pro Asn Ala Ala 
            20                  25                  30          


Ser Pro Gly Ala Glu Ala Pro Ser Ser Ser Glu Pro His Gly Ala Arg 
        35                  40                  45              


Gly Ser Ser Ser Ser Gly Gly Lys Lys Cys Tyr Lys Leu Glu Asn Glu 
    50                  55                  60                  


Lys Leu Phe Glu Glu Phe Leu Glu Leu Cys Lys Met Gln Thr Ala Asp 
65                  70                  75                  80  


His Pro Glu Val Val Pro Phe Leu Tyr Asn Arg Gln Gln Arg Ala His 
                85                  90                  95      


Ser Leu Phe Leu Ala Ser Ala Glu Phe Cys Asn Ile Leu Ser Arg Val 
            100                 105                 110         


Leu Ser Arg Ala Arg Ser Arg Pro Ala Lys Leu Tyr Val Tyr Ile Asn 
        115                 120                 125             


Glu Leu Cys Thr Val Leu Lys Ala His Ser Ala Lys Lys Lys Leu Asn 
    130                 135                 140                 


Leu Ala Pro Ala Ala Thr Thr Ser Asn Glu Pro Ser Gly Asn Asn Pro 
145                 150                 155                 160 


Pro Thr His Leu Ser Leu Asp Pro Thr Asn Ala Glu Asn Thr Ala Ser 
                165                 170                 175     


Gln Ser Pro Arg Thr Arg Gly Ser Arg Arg Gln Ile Gln Arg Leu Glu 
            180                 185                 190         


Gln Leu Leu Ala Leu Tyr Val Ala Glu Ile Arg Arg Leu Gln Glu Lys 
        195                 200                 205             


Glu Leu Asp Leu Ser Glu Leu Asp Asp Pro Asp Ser Ala Tyr Leu Gln 
    210                 215                 220                 


Glu Ala Arg Leu Lys Arg Lys Leu Ile Arg Leu Phe Gly Arg Leu Cys 
225                 230                 235                 240 


Glu Leu Lys Asp Cys Ser Ser Leu Thr Gly Arg Val Ile Glu Gln Arg 
                245                 250                 255     


Ile Pro Tyr Arg Gly Thr Arg Tyr Pro Glu Val Asn Arg Arg Ile Glu 
            260                 265                 270         


Arg Leu Ile Asn Lys Pro Gly Pro Asp Thr Phe Pro Asp Tyr Gly Asp 
        275                 280                 285             


Val Leu Arg Ala Val Glu Lys Ala Ala Ala Arg His Ser Leu Gly Leu 
    290                 295                 300                 


Pro Arg Gln Gln Leu Gln Leu Met Ala Gln Asp Ala Phe Arg Asp Val 
305                 310                 315                 320 


Gly Ile Arg Leu Gln Glu Arg Arg His Leu Asp Leu Ile Tyr Asn Phe 
                325                 330                 335     


Gly Cys His Leu Thr Asp Asp Tyr Arg Pro Gly Val Asp Pro Ala Leu 
            340                 345                 350         


Ser Asp Pro Val Leu Ala Arg Arg Leu Arg Glu Asn Arg Ser Leu Ala 
        355                 360                 365             


Met Ser Arg Leu Asp Glu Val Ile Ser Lys Tyr Ala Met Leu Gln Asp 
    370                 375                 380                 


Lys Ser Glu Glu Gly Glu Arg Lys Lys Arg Arg Ala Arg Leu Gln Gly 
385                 390                 395                 400 


Thr Ser Ser His Ser Ala Asp Thr Pro Glu Ala Ser Leu Asp Ser Gly 
                405                 410                 415     


Glu Gly Pro Ser Gly Met Ala Ser Gln Gly Cys Pro Ser Ala Ser Arg 
            420                 425                 430         


Ala Glu Thr Asp Asp Glu Asp Asp Glu Glu Ser Asp Glu Glu Glu Glu 
        435                 440                 445             


Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Thr Asp Ser Glu Glu Glu 
    450                 455                 460                 


Glu Asp Leu Glu Gln Met Gln Glu Gly Gln Glu Asp Asp Glu Glu Glu 
465                 470                 475                 480 


Asp Glu Glu Glu Glu Ala Ala Ala Gly Lys Asp Gly Asp Lys Ser Pro 
                485                 490                 495     


Met Ser Ser Leu Gln Ile Ser Asn Glu Lys Asn Leu Glu Pro Gly Lys 
            500                 505                 510         


Gln Ile Ser Arg Ser Ser Gly Glu Gln Gln Asn Lys Gly Arg Ile Val 
        515                 520                 525             


Ser Pro Ser Leu Leu Ser Glu Glu Pro Leu Ala Pro Ser Ser Ile Asp 
    530                 535                 540                 


Ala Glu Ser Asn Gly Glu Gln Pro Glu Glu Leu Thr Leu Glu Glu Glu 
545                 550                 555                 560 


Ser Pro Val Ser Gln Leu Phe Glu Leu Glu Ile Glu Ala Leu Pro Leu 
                565                 570                 575     


Asp Thr Pro Ser Ser Val Glu Thr Asp Ile Ser Ser Ser Arg Lys Gln 
            580                 585                 590         


Ser Glu Glu Pro Phe Thr Thr Val Leu Glu Asn Gly Ala Gly Met Val 
        595                 600                 605             


Ser Ser Thr Ser Phe Asn Gly Gly Val Ser Pro His Asn Trp Gly Asp 
    610                 615                 620                 


Ser Gly Pro Pro Cys Lys Lys Ser Arg Lys Glu Lys Lys Gln Thr Gly 
625                 630                 635                 640 


Ser Gly Pro Leu Gly Asn Ser Tyr Val Glu Arg Gln Arg Ser Val His 
                645                 650                 655     


Glu Lys Asn Gly Lys Lys Ile Cys Thr Leu Pro Ser Pro Pro Ser Pro 
            660                 665                 670         


Leu Ala Ser Leu Ala Pro Val Ala Asp Ser Ser Thr Arg Val Asp Ser 
        675                 680                 685             


Pro Ser His Gly Leu Val Thr Ser Ser Leu Cys Ile Pro Ser Pro Ala 
    690                 695                 700                 


Arg Leu Ser Gln Thr Pro His Ser Gln Pro Pro Arg Pro Gly Thr Cys 
705                 710                 715                 720 


Lys Thr Ser Val Ala Thr Gln Cys Asp Pro Glu Glu Ile Ile Val Leu 
                725                 730                 735     


Ser Asp Ser Asp 
            740 


<210>  2
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  2

Lys Ser Arg Lys Glu Lys Lys Gln Thr Gly Ser Gly Pro Leu Gly 
1               5                   10                  15  


<210>  3
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  3

Ser Gly Pro Pro Cys Lys Lys Ser Arg Lys Glu Lys Lys Gln Thr 
1               5                   10                  15  


<210>  4
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  4

Pro Cys Lys Lys Ser Arg Lys Glu Lys Lys Gln Thr Gly Ser Gly 
1               5                   10                  15  


<210>  5
<211>  16
<212>  PRT
<213>  homo sapiens

<400>  5

Lys Lys Ser Arg Lys Glu Lys Lys Gln Thr Gly Ser Gly Pro Leu Gly 
1               5                   10                  15      


<210>  6
<211>  14
<212>  PRT
<213>  homo sapiens

<400>  6

Ser Arg Lys Glu Lys Lys Gln Thr Gly Ser Gly Pro Leu Gly 
1               5                   10                  


<210>  7
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  7

Lys Ser Arg Lys Glu Lys Lys Gln Thr Gly Ser Gly Pro Leu Gly 
1               5                   10                  15  


<210>  8
<211>  208
<212>  PRT
<213>  homo sapiens

<400>  8

Met Asp Pro Phe Leu Val Leu Leu His Ser Val Ser Ser Ser Leu Ser 
1               5                   10                  15      


Ser Ser Glu Leu Thr Glu Leu Lys Phe Leu Cys Leu Gly Arg Val Gly 
            20                  25                  30          


Lys Arg Lys Leu Glu Arg Val Gln Ser Gly Leu Asp Leu Phe Ser Met 
        35                  40                  45              


Leu Leu Glu Gln Asn Asp Leu Glu Pro Gly His Thr Glu Leu Leu Arg 
    50                  55                  60                  


Glu Leu Leu Ala Ser Leu Arg Arg His Asp Leu Leu Arg Arg Val Asp 
65                  70                  75                  80  


Asp Phe Glu Ala Gly Ala Ala Ala Gly Ala Ala Pro Gly Glu Glu Asp 
                85                  90                  95      


Leu Cys Ala Ala Phe Asn Val Ile Cys Asp Asn Val Gly Lys Asp Trp 
            100                 105                 110         


Arg Arg Leu Ala Arg Gln Leu Lys Val Ser Asp Thr Lys Ile Asp Ser 
        115                 120                 125             


Ile Glu Asp Arg Tyr Pro Arg Asn Leu Thr Glu Arg Val Arg Glu Ser 
    130                 135                 140                 


Leu Arg Ile Trp Lys Asn Thr Glu Lys Glu Asn Ala Thr Val Ala His 
145                 150                 155                 160 


Leu Val Gly Ala Leu Arg Ser Cys Gln Met Asn Leu Val Ala Asp Leu 
                165                 170                 175     


Val Gln Glu Val Gln Gln Ala Arg Asp Leu Gln Asn Arg Ser Gly Ala 
            180                 185                 190         


Met Ser Pro Met Ser Trp Asn Ser Asp Ala Ser Thr Ser Glu Ala Ser 
        195                 200                 205             


<210>  9
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  9

Val Gly Lys Arg Lys Leu Glu Arg Val Gln Ser Gly Leu Asp Leu 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  10

Leu Gly Arg Val Gly Lys Arg Lys Leu Glu Arg Val Gln Ser Gly 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  11

Arg Lys Leu Glu Arg Val Gln Ser Gly Leu Asp Leu Phe Ser Met 
1               5                   10                  15  


<210>  12
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  12

Lys Arg Lys Leu Glu Arg Val Gln Ser 
1               5                   


<210>  13
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  13

Ala Lys Leu Tyr Val Tyr Ile Asn Glu Leu Cys Thr Val Leu Lys 
1               5                   10                  15  


<210>  14
<211>  13
<212>  PRT
<213>  homo sapiens

<400>  14

Arg Lys Glu Lys Lys Gln Thr Gly Ser Gly Pro Leu Gly 
1               5                   10              


<210>  15
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  15

Lys Arg Phe Arg Lys Glu Lys Lys Gln Leu Gly Ser Gly Leu Leu Gly 
1               5                   10                  15      


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scrambled peptide

<400>  16

Lys Lys Gly Arg Lys Gln Ser Gly Glu Ser Leu Gly Thr Pro Lys Lys 
1               5                   10                  15      


