                         LISTADO DE SECUENCIAS

<110>  Universidade de Santiago de Compostela
       Universidad de Valladolid
 
<120>  Nanopartculas para la prevencin y/o el tratamiento de 
       enfermedades de mucosas.

<130>  ES1596.21

<150>  P201031678
<151>  2010-11-15

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  7681
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  Secuencia Nucletidos MUC5AC modificada

<400>  1
atgagtgttg gccggaggaa gctggccctg ctctgggccc tggctctcgc tctggcctgc       60

acccggcaca caggccatgc ccaggatggc tcctccgaat ccagctacaa gcaccaccct      120

gccctcttcc tatcgcccgg gggcccagcg gggtcccgct ccgtggggcg actgtcttcc      180

catctctgag gaccatccct gtggtacgag cctccaaccc agcgcacaac gggcgggtgt      240

gcagcacctg gggcagcttc catacaagac cttcgacggc gacgtcttcc gcttccccgg      300

cctctgcaac tacgtgttct ccgagcactg cggtgccgcc tacgaggatt ttaacatcca      360

gctacgccgc agccaggagt cagcggcccc cacgctggca gggtcctcat gaaggtggat      420

ggcgtggtca tccagctgac caagggctcc gtcctggtca acggccaccc ggtcctgctg      480

cccttcagcc agtctggggt cctcattcag cagagcagca gctacaccaa ggggaggcca      540

ggctgggcct tgtcctcatg tggaaccacg atgacagcct gctgctggag ctggacacca      600

aatacgccaa caagacctgt gggctctgtg gggacttcaa cgggatgccc gtggtcagcg      660

agctccttcc cacaacacca agctgacacc catggaattc gggaacctgc agaagatgga      720

cgaccccacg gagcagtgtc aggaccctgt ccctgaaccc ccgaggaact gctccactgg      780

ctttggcatc tgtgaggagc tctgcacggc cagctgttct ctggctgcgt ggccctggtg      840

gacgtcggca gctacctgga ggcttgcagg caagacctct gcttctgtga agacaccgac      900

ctgctcagct gcgtctgcca cacccttgcc gagtactccg gcagtgcacc catgcagggg      960

ggttgcccca ggactggcgg ggccctgact tctgccccca gaagtgcccc aacaacatgc     1020

agtaccacga gtgccgctcc ccctgcgcag acacctgctc caaccaggag catcccgggc     1080

ctgtgaggac cactgtgtgg ccggctgctt ctgccctgag gggacggtgc ttgacgacat     1140

cggccagacc ggctgtgtcc ctgtgtcaaa gtgtgcctgc gtctacaacg gggctgccta     1200

tgccccaggg ccacctactc cacagactgc accaactgca cctgctccgg aggccggtgg     1260

agctgccagg aggttccatg cccggatacc tgctctgtgc ttggaggtgc ccacttctca     1320

acgtttgacg ggaagcaata caggtgcacg gcgactgcag ctatgtgctg accaagccct     1380

gtgacagcag tgccttcact gtactggctg agctgcgcag gtgcgggctg acggacagcg     1440

agacctgcct gaagagcgtg acactgagcc tggatgggcg cagacggtgg tggtgatcaa     1500

ggccagtggg gaagtgttcc tgaaccagat ctacacccag ctgcccatct ctgcagccaa     1560

cgtcaccatc ttcagaccct caaccttctt catcatcgcc cagaccagcc tggcctgcag     1620

ctgaacctgc agccggtgcc caccatgcag ctgttcatgc agctggcgcc caagctccgt     1680

gggcagacct gcggtctctg tgggaacttc aacagcatcc aggccgatga cttccggacc     1740

ctcagtgggt ggtggaggcc accgctgcgg ccttcttcaa caccttcaag acccaggccg     1800

cctgccccaa catcaggaac agcttcgagg acccctgctc tctgagcgtg gagaatgaga     1860

agtatgctca gcactggtgc tccagctgac cgatgccgac ggccccttcg gccggtgcca     1920

tgctgccgtg aagccgggaa cctactactc gaactgcgtg tttgacacct gcaactgtga     1980

gcggagcgag gactgcctgt gcgccgcgct gtcctccacg tgcacgcctg tgccgccaag     2040

ggcgtgcagc tcggcggctg gagggacggc gtctgcacga agcctatgac cacttgcccc     2100

aagtcaatga cgtaccacta ccatgtcagc acctgccagc ccacctgccg ctcctgagcg     2160

agggggacat cacctgcagt gttggcttca tccccgtgga tggctgcatc tgtcccaagg     2220

gcaccttcct ggacgacacg ggcaagtgtg tgcaggccag caactgtccc tgctaccaca     2280

gaggctcatg atccccaatg gggagtcggt gcacgacagc ggggctatct gcacctgcac     2340

acatgggaag ctgagctgca tcggaggcca agcccccgcc ccagtgtgtg ctgcgcccat     2400

ggtgttcttt gactgccgaa atccacgccc ggggacacag gggctggctg tcagaagagc     2460

tgccacacac tggacatgac ctgttacagc ccccagtgtg tgcctggctg cgtgtgcccc     2520

gacgggctgg tggcggacgg cgagggcggc tgcatcatgc ggaggactgc ccctgcgtgc     2580

acaatgaggc cagctaccgg gccggccaga ccatccgggt gggctgcaac acctgcacct     2640

gtgacagcag gatgtggcgg tgcacagatg acccctgcct ggccacctgc gcgtgtacgg     2700

ggacggccac tacctcacct tcgacggaca gagctacagc ttcaacggag actgcgagta     2760

cacgctggtg cagaaccact gtggcgggaa agacagcacc caggactcct ttcgtgttgt     2820

caccgagacg tcccctgcgg caccacaggg accacctgct ccaaggccat caagattttc     2880

ctggggggct tcgagctgaa gctaagccat gggaaggtgg aggtgatcgg gacggacgag     2940

agccaggagg tgccatacac caccagcaga tgggcatcta cctggtggtg gacaccgaca     3000

ttggcctggt gctgctgtgg gacaagaaga ccagcatctt catcaacctc agccccgagt     3060

tcaagggcag ggtctgcggc ctgtgtggga acttcgagac atcgccgtta atgactttgc     3120

cacgcggagc cggtctgtgg tgggggacgt gctggagttt gggaacagct ggaagctctc     3180

cccctcctgc ccagatgccc tggcgcccaa ggacccctgc acggccaacc cctccgcaag     3240

tcctgggccc agaagcagtg cagcatcctc cacggcccca ccttcgccgc ctgccacgca     3300

cacgtggagc cggccaggta ctacgaggcc tgcgtgaacg acgcgtgcgc ctgcgactcc     3360

gggggtgctg cgagtgcttc tgcacggctg tggccgccta cgcccaggcc tgccatgaag     3420

taggcctgtg tgtgtgtctg cggaccccga gcatctgccc tctgttctgc gactactaca     3480

accccgaagg ccagtgcgag tgcactacca gccctgcggg gtgccctgcc tgcgcacctg     3540

ccggaacccc cgtggagact gtctgcggga cgtccggggg ctggaaggct gctaccccaa     3600

gtgcccacca gaggctccca tctttgatga ggacaagtgc agtgtgtggc cacctgccca     3660

accccgcctc tgccaccacg gtgccacgtc catgggaagt cctaccggcc aggtgcagtg     3720

gtgccctcgg acaagaactg ccagtcctgc ctttgtacgg agcgcggcgt gggtgcacct     3780

acaaagctga ggcctgtgtc tgcacctaca atggacagcg cttccaccca ggggacgtca     3840

tctaccacac gacggatggc acgggtggct gcatctccgc ccgctgcggg gccaacggca     3900

ccattgaagg agggtctacc cctgcagccc caccacccct gtccccccaa ccaccttctc     3960

cttctccaca cccccgcttg tcgtgagctc cacgcacacc cccagcaatg gcccaagcag     4020

cgcgcacaca ggccctccga gcgcgcctgg cccaccacag caggcacttc tcccaggacg     4080

aggctgccca cagcctctgc ctcgctgccg ccggtctgtg gggaaaagtg cctctggtcg     4140

ccatggatgg atgtcagccg ccctggacgg ggcacggcag cggtgacttc gacacactgg     4200

agaacctccg cgcccatggg taccgggtgt gcgaatcacc caggtcggtg gagtgccgag     4260

ctgaggacgc ccccggagtg ccgctccgag ccctggggca gcgtgtgcag tgagcccgga     4320

tgtggggctg acctgtcgta acagggagca ggcatcgggg ctctgctaca actaccagat     4380

cagggtccag tgctgcacgc ccctaccctg ctccacctct agcagtccag cccagaccac     4440

tcctccacta cctccaagac cactgaaacc cgggcctcag gctcctcagc tcccagcagc     4500

acacctggca ccgtgtctct ctccacagcc aggacgacac ctgccccagg taccgctacc     4560

tctgtcaaaa aaactttctc aatcccagcc ctccgccagt gccggcaaca tcaacatcat     4620

ccatgtcgac cacggccccg gggacctctg tggtctccag caagcccacc cccacggagc     4680

ccagcacatc ctcctgcctg caggagcttt gcacctgacc gagtggatcg atggcagcta     4740

ccctgctcct ggaataaatg gtggagattt tgacacattt caaaatttga gagacgaagg     4800

atacacattc tgtgaaagtc ctcgaagcgt gcagtgccgg gcagagagct tcccaacacg     4860

ccgctggcag acctggggca ggacgtcatc tgcagccaca cagaggggct gatttgcctg     4920

aacaagaacc agctcccacc catctgctac aactatgaga tccgcatcca gtgttgcgag     4980

acggtgacgt gtgcagagac atcaccagac tgccaaagac cgtcgcaacg acacggccga     5040

ctccacatcc aaccggagct cagacccaga ccaccttcac cacacacatg ccctcggcct     5100

ccacagagca acccacggca actccagggg tgggcccaca gcaaccagcg tcacacaggg     5160

cacccacacc acactagtca ccagaaactg tcatccccgg tgcacctgga caaagtggtt     5220

cgacgtggac ttcccgtccc ccggacccca tggtggaaca aggaaaccta caacaacatc     5280

atcaggagtg gggaaaaaat ctgccgccga cctgaggaga tcaccagggt ccagtgccga     5340

gccaagagcc acccagaggt gagcatcgaa cacctgggcc aggtggtgca gtcagccggg     5400

aagagggcct ggtgtgccgg aaccaggacc agcagggacc cttcaagatg tgcctcaact     5460

acgaggtgcg tgtgctctgc tgcgagaccc ccagaggctg ccacatgacc tccacacctg     5520

gctccactct agcagtccag cccagaccac tccttcaaca acctccaaga ccactgaaat     5580

ccaggcctca ggctcctcag cccccagcag cacacctggc accgtgtctc tctctacagc     5640

caggacgaca cctgccccag gtccgctacc tctgtcaaaa aaactttctc aactcccagc     5700

cctccgccag tgccggcaac atcaacatca tccatgtcga ccacggcccc ggggacctct     5760

gtggtctcca gcaagcccac ccccacggag cccagcaatc ctcctgcctg caggagcttt     5820

gcacctggac cgagtggatt gatggcagct accctgctcc tggaataaat ggtggagatt     5880

ttgacacatt tcaaaatttg agagacgaag gatacacatt ctgtgaaagt cccgaagcgt     5940

gcagtgccgg gcagagagct tccccaacac gccgctgggc agactggggc aggacgtcat     6000

ctgcagccac acagaggggc tgatttgcct gaacaagaac cagctcccac ccatctgcta     6060

caactataga tccgaatcca gtgttgcgag acggtgaacg tgtgcagaga catcaccaga     6120

ccgccaaaga ccgtcgcaac gacgcggccg actccacatc caaccggagc tcagacccag     6180

accaccttca ccacacacat gcctcggcct ccacagagca acccacggca acctccaggg     6240

gtgggcccac agcaaccagc gtcacacagg gcacccacac cacaccagtc accagaaact     6300

gtcatccccg gtgcacctgg acaacgtggt tcgacgtgac ttcccgtccc ccggacccca     6360

tggtggagac aaggaaacct acaacaacat catcaggagt ggggaaaaaa tctgccgccg     6420

acctgaggag atcaccaggc tccagtgccg agccaagagc cacccagagg tggcatcgaa     6480

cacctgggcc aggtggtgca gtgcagccgg gaagagggcc tggtgtgccg gaaccaggac     6540

cagcagggac ccttcaagat gtgcctcaac atcgaggtgc gtgtgctctg ctgcgagacc     6600

cccaaagctg ccccgtgacc tccacacctg tgacagctcc tagcacccct agtgggagag     6660

ccatcagccc aactcagagc acctcctctt ggcagaaatc caggacaacc actttggtga     6720

caaccagcac aacctccact cccagaccag tacaacctat gcccatacaa ccagcacaac     6780

ctctgctcct acagccagaa caacctctgc tcctacaacc agcacaactt ctgtccctac     6840

aaccagcaca atctctggtc ctaaaactac tccgagcctg ttcctaccac cagcacaacc     6900

tctgctgcta caacaagcac aatctctgct cctacaacga gcacaacttc tgtccctgga     6960

actactccca gccctgttct caccaccagc acaacctctg ctcctacaac caaacaacct     7020

ctgcctctcc agccggcaca acctctggtc ctggaaatac tcccagccct gttcctacca     7080

ccagcacaat ctctgctcct acaactagca taacctctgc ccctacaacc agcacaacct     7140

ctgccccaca agcagcacaa cctctggtcc tggaactact cccagccctg ttcctaccac     7200

cagcataacc tctgccccta caaccagcac aacctctgct cctacaacca gcacaacctc     7260

tgctcccaca acgagcacga ctctgcccct ccgtaccaga accagtcgac ctgtgctgtg     7320

taccatagga gcctgatcat ccagcagcag ggctgcagct cctcggagcc cgtgcgcctg     7380

gcttactgcc gggggaactg tggggacagc tcttccagta ctcgctcgag ggcaacacgg     7440

tggagcacag gtgccagtgc tgccaggagc tgcggacctc gctgaggaat gtgaccctgc     7500

actgcaccga cggctccagc cgggccttca gctacaccga ggtggaagag tgggctgcat     7560

gggccggcgg tgccctgcgc cgggcgacac ccagcactcg gaggaggcgg aacccgagcc     7620

cagccaggag gcagagagtg ggagctggga gagaggcgtc ccagtgtccc ccatgcactg     7680

a                                                                     7681


<210>  2
<211>  2578
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  MUC5AC modificada

<400>  2

Met Ser Val Gly Arg Arg Lys Leu Ala Leu Leu Trp Ala Leu Ala Leu 
1               5                   10                  15      


Ala Leu Ala Cys Thr Arg His Thr Gly His Ala Gln Asp Gly Ser Ser 
            20                  25                  30          


Glu Ser Ser Tyr Lys His His Pro Ala Leu Ser Pro Ile Ala Arg Gly 
        35                  40                  45              


Pro Ser Gly Val Pro Leu Arg Gly Ala Thr Val Phe Pro Ser Leu Arg 
    50                  55                  60                  


Thr Ile Pro Val Val Arg Ala Ser Asn Pro Ala His Asn Gly Arg Val 
65                  70                  75                  80  


Cys Ser Thr Trp Gly Ser Phe His Tyr Lys Thr Phe Asp Gly Asp Val 
                85                  90                  95      


Phe Arg Phe Pro Gly Leu Cys Asn Tyr Val Phe Ser Glu His Cys Gly 
            100                 105                 110         


Ala Ala Tyr Glu Asp Phe Asn Ile Gln Leu Arg Arg Ser Gln Glu Ser 
        115                 120                 125             


Ala Ala Pro Thr Leu Ser Arg Val Leu Met Lys Val Asp Gly Val Val 
    130                 135                 140                 


Ile Gln Leu Thr Lys Gly Ser Val Leu Val Asn Gly His Pro Val Leu 
145                 150                 155                 160 


Leu Pro Phe Ser Gln Ser Gly Val Leu Ile Gln Gln Ser Ser Ser Tyr 
                165                 170                 175     


Thr Lys Val Glu Ala Arg Leu Gly Leu Val Leu Met Trp Asn His Asp 
            180                 185                 190         


Asp Ser Leu Leu Leu Glu Leu Asp Thr Lys Tyr Ala Asn Lys Thr Cys 
        195                 200                 205             


Gly Leu Cys Gly Asp Phe Asn Gly Met Pro Val Val Ser Glu Leu Leu 
    210                 215                 220                 


Ser His Asn Thr Lys Leu Thr Pro Met Glu Phe Gly Asn Leu Gln Lys 
225                 230                 235                 240 


Met Asp Asp Pro Thr Glu Gln Cys Gln Asp Pro Val Pro Glu Pro Pro 
                245                 250                 255     


Arg Asn Cys Ser Thr Gly Phe Gly Ile Cys Glu Glu Leu Leu His Gly 
            260                 265                 270         


Gln Leu Phe Ser Gly Cys Val Ala Leu Val Asp Val Gly Ser Tyr Leu 
        275                 280                 285             


Glu Ala Cys Arg Gln Asp Leu Cys Phe Cys Glu Asp Thr Asp Leu Leu 
    290                 295                 300                 


Ser Cys Val Cys His Thr Leu Ala Glu Tyr Ser Arg Gln Cys Thr His 
305                 310                 315                 320 


Ala Gly Gly Leu Pro Gln Asp Trp Arg Gly Pro Asp Phe Cys Pro Gln 
                325                 330                 335     


Lys Cys Pro Asn Asn Met Gln Tyr His Glu Cys Arg Ser Pro Cys Ala 
            340                 345                 350         


Asp Thr Cys Ser Asn Gln Glu His Ser Arg Ala Cys Glu Asp His Cys 
        355                 360                 365             


Val Ala Gly Cys Phe Cys Pro Glu Gly Thr Val Leu Asp Asp Ile Gly 
    370                 375                 380                 


Gln Thr Gly Cys Val Pro Val Ser Lys Cys Ala Cys Val Tyr Asn Gly 
385                 390                 395                 400 


Ala Ala Tyr Ala Pro Gly Ala Thr Tyr Ser Thr Asp Cys Thr Asn Cys 
                405                 410                 415     


Thr Cys Ser Gly Gly Arg Trp Ser Cys Gln Glu Val Pro Cys Pro Asp 
            420                 425                 430         


Thr Cys Ser Val Leu Gly Gly Ala His Phe Ser Thr Phe Asp Gly Lys 
        435                 440                 445             


Gln Tyr Thr Val His Gly Asp Cys Ser Tyr Val Leu Thr Lys Pro Cys 
    450                 455                 460                 


Asp Ser Ser Ala Phe Thr Val Leu Ala Glu Leu Arg Arg Cys Gly Leu 
465                 470                 475                 480 


Thr Asp Ser Glu Thr Cys Leu Lys Ser Val Thr Leu Ser Leu Asp Gly 
                485                 490                 495     


Ala Gln Thr Val Val Val Ile Lys Ala Ser Gly Glu Val Phe Leu Asn 
            500                 505                 510         


Gln Ile Tyr Thr Gln Leu Pro Ile Ser Ala Ala Asn Val Thr Ile Phe 
        515                 520                 525             


Arg Pro Ser Thr Phe Phe Ile Ile Ala Gln Thr Ser Leu Gly Leu Gln 
    530                 535                 540                 


Leu Asn Leu Gln Pro Val Pro Thr Met Gln Leu Phe Met Gln Leu Ala 
545                 550                 555                 560 


Pro Lys Leu Arg Gly Gln Thr Cys Gly Leu Cys Gly Asn Phe Asn Ser 
                565                 570                 575     


Ile Gln Ala Asp Asp Phe Arg Thr Leu Ser Gly Val Val Glu Ala Thr 
            580                 585                 590         


Ala Ala Ala Phe Phe Asn Thr Phe Lys Thr Gln Ala Ala Cys Pro Asn 
        595                 600                 605             


Ile Arg Asn Ser Phe Glu Asp Pro Cys Ser Leu Ser Val Glu Asn Glu 
    610                 615                 620                 


Lys Tyr Ala Gln His Trp Cys Ser Gln Leu Thr Asp Ala Asp Gly Pro 
625                 630                 635                 640 


Phe Gly Arg Cys His Ala Ala Val Lys Pro Gly Thr Tyr Tyr Ser Asn 
                645                 650                 655     


Cys Val Phe Asp Thr Cys Asn Cys Glu Arg Ser Glu Asp Cys Leu Cys 
            660                 665                 670         


Ala Ala Leu Ser Ser Tyr Val His Ala Cys Ala Ala Lys Gly Val Gln 
        675                 680                 685             


Leu Gly Gly Trp Arg Asp Gly Val Cys Thr Lys Pro Met Thr Thr Cys 
    690                 695                 700                 


Pro Lys Ser Met Thr Tyr His Tyr His Val Ser Thr Cys Gln Pro Thr 
705                 710                 715                 720 


Cys Arg Ser Leu Ser Glu Gly Asp Ile Thr Cys Ser Val Gly Phe Ile 
                725                 730                 735     


Pro Val Asp Gly Cys Ile Cys Pro Lys Gly Thr Phe Leu Asp Asp Thr 
            740                 745                 750         


Gly Lys Cys Val Gln Ala Ser Asn Cys Pro Cys Tyr His Arg Gly Ser 
        755                 760                 765             


Met Ile Pro Asn Gly Glu Ser Val His Asp Ser Gly Ala Ile Cys Thr 
    770                 775                 780                 


Cys Thr His Gly Lys Leu Ser Cys Ile Gly Gly Gln Ala Pro Ala Pro 
785                 790                 795                 800 


Val Cys Ala Ala Pro Met Val Phe Phe Asp Cys Arg Asn Ala Thr Pro 
                805                 810                 815     


Gly Asp Thr Gly Ala Gly Cys Gln Lys Ser Cys His Thr Leu Asp Met 
            820                 825                 830         


Thr Cys Tyr Ser Pro Gln Cys Val Pro Gly Cys Val Cys Pro Asp Gly 
        835                 840                 845             


Leu Val Ala Asp Gly Glu Gly Gly Cys Ile Thr Ala Glu Asp Cys Pro 
    850                 855                 860                 


Cys Val His Asn Glu Ala Ser Tyr Arg Ala Gly Gln Thr Ile Arg Val 
865                 870                 875                 880 


Gly Cys Asn Thr Cys Thr Cys Asp Ser Arg Met Trp Arg Cys Thr Asp 
                885                 890                 895     


Asp Pro Cys Leu Ala Thr Cys Ala Val Tyr Gly Asp Gly His Tyr Leu 
            900                 905                 910         


Thr Phe Asp Gly Gln Ser Tyr Ser Phe Asn Gly Asp Cys Glu Tyr Thr 
        915                 920                 925             


Leu Val Gln Asn His Cys Gly Gly Lys Asp Ser Thr Gln Asp Ser Phe 
    930                 935                 940                 


Arg Val Val Thr Glu Asn Val Pro Cys Gly Thr Thr Gly Thr Thr Cys 
945                 950                 955                 960 


Ser Lys Ala Ile Lys Ile Phe Leu Gly Gly Phe Glu Leu Lys Leu Ser 
                965                 970                 975     


His Gly Lys Val Glu Val Ile Gly Thr Asp Glu Ser Gln Glu Val Pro 
            980                 985                 990         


Tyr Thr Ile Gln Gln Met Gly Ile  Tyr Leu Val Val Asp  Thr Asp Ile 
        995                 1000                 1005             


Gly Leu  Val Leu Leu Trp Asp  Lys Lys Thr Ser Ile  Phe Ile Asn 
    1010                 1015                 1020             


Leu Ser  Pro Glu Phe Lys Gly  Arg Val Cys Gly Leu  Cys Gly Asn 
    1025                 1030                 1035             


Phe Asp  Asp Ile Ala Val Asn  Asp Phe Ala Thr Arg  Ser Arg Ser 
    1040                 1045                 1050             


Val Val  Gly Asp Val Leu Glu  Phe Gly Asn Ser Trp  Lys Leu Ser 
    1055                 1060                 1065             


Pro Ser  Cys Pro Asp Ala Leu  Ala Pro Lys Asp Pro  Cys Thr Ala 
    1070                 1075                 1080             


Asn Pro  Phe Arg Lys Ser Trp  Ala Gln Lys Gln Cys  Ser Ile Leu 
    1085                 1090                 1095             


His Gly  Pro Thr Phe Ala Ala  Cys His Ala His Val  Glu Pro Ala 
    1100                 1105                 1110             


Arg Tyr  Tyr Glu Ala Cys Val  Asn Asp Ala Cys Ala  Cys Asp Ser 
    1115                 1120                 1125             


Gly Gly  Asp Cys Glu Cys Phe  Cys Thr Ala Val Ala  Ala Tyr Ala 
    1130                 1135                 1140             


Gln Ala  Cys His Glu Val Gly  Leu Cys Val Cys Leu  Arg Thr Pro 
    1145                 1150                 1155             


Ser Ile  Cys Pro Leu Phe Cys  Asp Tyr Tyr Asn Pro  Glu Gly Gln 
    1160                 1165                 1170             


Cys Glu  Trp His Tyr Gln Pro  Cys Gly Val Pro Cys  Leu Arg Thr 
    1175                 1180                 1185             


Cys Arg  Asn Pro Arg Gly Asp  Cys Leu Arg Asp Val  Arg Gly Leu 
    1190                 1195                 1200             


Glu Gly  Cys Tyr Pro Lys Cys  Pro Pro Glu Ala Pro  Ile Phe Asp 
    1205                 1210                 1215             


Glu Asp  Lys Met Gln Cys Val  Ala Thr Cys Pro Thr  Pro Pro Leu 
    1220                 1225                 1230             


Pro Pro  Arg Cys His Val His  Gly Lys Ser Tyr Arg  Pro Gly Ala 
    1235                 1240                 1245             


Val Val  Pro Ser Asp Lys Asn  Cys Gln Ser Cys Leu  Cys Thr Glu 
    1250                 1255                 1260             


Arg Gly  Val Glu Cys Thr Tyr  Lys Ala Glu Ala Cys  Val Cys Thr 
    1265                 1270                 1275             


Tyr Asn  Gly Gln Arg Phe His  Pro Gly Asp Val Ile  Tyr His Thr 
    1280                 1285                 1290             


Thr Asp  Gly Thr Gly Gly Cys  Ile Ser Ala Arg Cys  Gly Ala Asn 
    1295                 1300                 1305             


Gly Thr  Ile Glu Arg Arg Val  Tyr Pro Cys Ser Pro  Thr Thr Pro 
    1310                 1315                 1320             


Val Pro  Pro Thr Thr Phe Ser  Phe Ser Thr Pro Pro  Leu Val Val 
    1325                 1330                 1335             


Ser Ser  Thr His Thr Pro Ser  Asn Gly Pro Ser Ser  Ala His Thr 
    1340                 1345                 1350             


Gly Pro  Pro Ser Ser Ala Trp  Pro Thr Thr Ala Gly  Thr Ser Pro 
    1355                 1360                 1365             


Arg Thr  Arg Leu Pro Thr Ala  Ser Ala Ser Leu Pro  Pro Val Cys 
    1370                 1375                 1380             


Gly Glu  Lys Cys Leu Trp Ser  Pro Trp Met Asp Val  Ser Arg Pro 
    1385                 1390                 1395             


Gly Arg  Gly Thr Asp Ser Gly  Asp Phe Asp Thr Leu  Glu Asn Leu 
    1400                 1405                 1410             


Arg Ala  His Gly Tyr Arg Val  Cys Glu Ser Pro Arg  Ser Val Glu 
    1415                 1420                 1425             


Cys Arg  Ala Glu Asp Ala Pro  Gly Val Pro Leu Arg  Ala Leu Gly 
    1430                 1435                 1440             


Gln Arg  Val Gln Cys Ser Pro  Asp Val Gly Leu Thr  Cys Arg Asn 
    1445                 1450                 1455             


Arg Glu  Gln Ala Ser Gly Leu  Cys Tyr Asn Tyr Gln  Ile Arg Val 
    1460                 1465                 1470             


Gln Cys  Cys Thr Pro Leu Pro  Cys Ser Thr Ser Ser  Ser Pro Ala 
    1475                 1480                 1485             


Gln Thr  Thr Pro Pro Thr Thr  Ser Lys Thr Thr Glu  Thr Arg Ala 
    1490                 1495                 1500             


Ser Gly  Ser Ser Ala Pro Ser  Ser Thr Pro Gly Thr  Val Ser Leu 
    1505                 1510                 1515             


Ser Thr  Ala Arg Thr Thr Pro  Ala Pro Gly Thr Ala  Thr Ser Val 
    1520                 1525                 1530             


Lys Lys  Thr Phe Ser Thr Pro  Ser Pro Pro Pro Val  Pro Ala Thr 
    1535                 1540                 1545             


Ser Thr  Ser Ser Met Ser Thr  Thr Ala Pro Gly Thr  Ser Val Val 
    1550                 1555                 1560             


Ser Ser  Lys Pro Thr Pro Thr  Glu Pro Ser Thr Ser  Ser Cys Leu 
    1565                 1570                 1575             


Gln Glu  Leu Cys Thr Trp Thr  Glu Trp Ile Asp Gly  Ser Tyr Pro 
    1580                 1585                 1590             


Ala Pro  Gly Ile Asn Gly Gly  Asp Phe Asp Thr Phe  Gln Asn Leu 
    1595                 1600                 1605             


Arg Asp  Glu Gly Tyr Thr Phe  Cys Glu Ser Pro Arg  Ser Val Gln 
    1610                 1615                 1620             


Cys Arg  Ala Glu Ser Phe Pro  Asn Thr Pro Leu Ala  Asp Leu Gly 
    1625                 1630                 1635             


Gln Asp  Val Ile Cys Ser His  Thr Glu Gly Leu Ile  Cys Leu Asn 
    1640                 1645                 1650             


Lys Asn  Gln Leu Pro Pro Ile  Cys Tyr Asn Tyr Glu  Ile Arg Ile 
    1655                 1660                 1665             


Gln Cys  Cys Glu Thr Val Asn  Val Cys Arg Asp Ile  Thr Arg Leu 
    1670                 1675                 1680             


Pro Lys  Thr Val Ala Thr Thr  Arg Pro Thr Pro His  Pro Thr Gly 
    1685                 1690                 1695             


Ala Gln  Thr Gln Thr Thr Phe  Thr Thr His Met Pro  Ser Ala Ser 
    1700                 1705                 1710             


Thr Glu  Gln Pro Thr Ala Thr  Ser Arg Gly Gly Pro  Thr Ala Thr 
    1715                 1720                 1725             


Ser Val  Thr Gln Gly Thr His  Thr Thr Leu Val Thr  Arg Asn Cys 
    1730                 1735                 1740             


His Pro  Arg Cys Thr Trp Thr  Lys Trp Phe Asp Val  Asp Phe Pro 
    1745                 1750                 1755             


Ser Pro  Gly Pro His Gly Gly  Asp Lys Glu Thr Tyr  Asn Asn Ile 
    1760                 1765                 1770             


Ile Arg  Ser Gly Glu Lys Ile  Cys Arg Arg Pro Glu  Glu Ile Thr 
    1775                 1780                 1785             


Arg Val  Gln Cys Arg Ala Lys  Ser His Pro Glu Val  Ser Ile Glu 
    1790                 1795                 1800             


His Leu  Gly Gln Val Val Gln  Cys Ser Arg Glu Glu  Gly Leu Val 
    1805                 1810                 1815             


Cys Arg  Asn Gln Asp Gln Gln  Gly Pro Phe Lys Met  Cys Leu Asn 
    1820                 1825                 1830             


Tyr Glu  Val Arg Val Leu Cys  Cys Glu Thr Pro Arg  Gly Cys His 
    1835                 1840                 1845             


Met Thr  Ser Thr Pro Gly Ser  Thr Ser Ser Ser Pro  Ala Gln Thr 
    1850                 1855                 1860             


Thr Pro  Ser Thr Thr Ser Lys  Thr Thr Glu Ile Gln  Ala Ser Gly 
    1865                 1870                 1875             


Ser Ser  Ala Pro Ser Ser Thr  Pro Gly Thr Val Ser  Leu Ser Thr 
    1880                 1885                 1890             


Ala Arg  Thr Thr Pro Ala Pro  Gly Thr Ala Thr Ser  Val Lys Lys 
    1895                 1900                 1905             


Thr Phe  Ser Thr Pro Ser Pro  Pro Pro Val Pro Ala  Thr Ser Thr 
    1910                 1915                 1920             


Ser Ser  Met Ser Thr Thr Ala  Pro Gly Thr Ser Val  Val Ser Ser 
    1925                 1930                 1935             


Lys Pro  Thr Pro Thr Glu Pro  Ser Thr Ser Ser Cys  Leu Gln Glu 
    1940                 1945                 1950             


Leu Cys  Thr Trp Thr Glu Trp  Ile Asp Gly Ser Tyr  Pro Ala Pro 
    1955                 1960                 1965             


Gly Ile  Asn Gly Gly Asp Phe  Asp Thr Phe Gln Asn  Leu Arg Asp 
    1970                 1975                 1980             


Glu Gly  Tyr Thr Phe Cys Glu  Ser Pro Arg Ser Val  Gln Cys Arg 
    1985                 1990                 1995             


Ala Glu  Ser Phe Pro Asn Thr  Pro Leu Gly Arg Leu  Gly Gln Asp 
    2000                 2005                 2010             


Val Ile  Cys Ser His Thr Glu  Gly Leu Ile Cys Leu  Asn Lys Asn 
    2015                 2020                 2025             


Gln Leu  Pro Pro Ile Cys Tyr  Asn Tyr Glu Ile Arg  Ile Gln Cys 
    2030                 2035                 2040             


Cys Glu  Thr Val Asn Val Cys  Arg Asp Ile Thr Arg  Pro Pro Lys 
    2045                 2050                 2055             


Thr Val  Ala Thr Thr Arg Pro  Thr Pro His Pro Thr  Gly Ala Gln 
    2060                 2065                 2070             


Thr Gln  Thr Thr Phe Thr Thr  His Met Pro Ser Ala  Ser Thr Glu 
    2075                 2080                 2085             


Gln Pro  Thr Ala Thr Ser Arg  Gly Gly Pro Thr Ala  Thr Ser Val 
    2090                 2095                 2100             


Thr Gln  Gly Thr His Thr Thr  Pro Val Thr Arg Asn  Cys His Pro 
    2105                 2110                 2115             


Arg Cys  Thr Trp Thr Thr Trp  Phe Asp Val Asp Phe  Pro Ser Pro 
    2120                 2125                 2130             


Gly Pro  His Gly Gly Asp Lys  Glu Thr Tyr Asn Asn  Ile Ile Arg 
    2135                 2140                 2145             


Ser Gly  Glu Lys Ile Cys Arg  Arg Pro Glu Glu Ile  Thr Arg Leu 
    2150                 2155                 2160             


Gln Cys  Arg Ala Lys Ser His  Pro Glu Val Ser Ile  Glu His Leu 
    2165                 2170                 2175             


Gly Gln  Val Val Gln Cys Ser  Arg Glu Glu Gly Leu  Val Cys Arg 
    2180                 2185                 2190             


Asn Gln  Asp Gln Gln Gly Pro  Phe Lys Met Cys Leu  Asn Ile Glu 
    2195                 2200                 2205             


Val Arg  Val Leu Cys Cys Glu  Thr Pro Lys Gly Cys  Pro Val Thr 
    2210                 2215                 2220             


Ser Thr  Pro Val Thr Ala Pro  Ser Thr Pro Ser Gly  Arg Ala Ile 
    2225                 2230                 2235             


Ser Pro  Thr Gln Ser Thr Ser  Ser Trp Gln Lys Ser  Arg Thr Thr 
    2240                 2245                 2250             


Thr Leu  Val Thr Thr Ser Thr  Thr Ser Thr Pro Gln  Thr Ser Thr 
    2255                 2260                 2265             


Thr Tyr  Ala His Thr Thr Ser  Thr Thr Ser Ala Pro  Thr Ala Arg 
    2270                 2275                 2280             


Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Thr Ser Val  Pro Thr Thr 
    2285                 2290                 2295             


Ser Thr  Ile Ser Gly Pro Lys  Thr Thr Pro Ser Pro  Val Pro Thr 
    2300                 2305                 2310             


Thr Ser  Thr Thr Ser Ala Ala  Thr Thr Ser Thr Ile  Ser Ala Pro 
    2315                 2320                 2325             


Thr Thr  Ser Thr Thr Ser Val  Pro Gly Thr Thr Pro  Ser Pro Val 
    2330                 2335                 2340             


Leu Thr  Thr Ser Thr Thr Ser  Ala Pro Thr Thr Arg  Thr Thr Ser 
    2345                 2350                 2355             


Ala Ser  Pro Ala Gly Thr Thr  Ser Gly Pro Gly Asn  Thr Pro Ser 
    2360                 2365                 2370             


Pro Val  Pro Thr Thr Ser Thr  Ile Ser Ala Pro Thr  Thr Ser Ile 
    2375                 2380                 2385             


Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser Ala Pro  Thr Ser Ser 
    2390                 2395                 2400             


Thr Thr  Ser Gly Pro Gly Thr  Thr Pro Ser Pro Val  Pro Thr Thr 
    2405                 2410                 2415             


Ser Ile  Thr Ser Ala Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Thr 
    2420                 2425                 2430             


Thr Ser  Thr Thr Ser Ala Pro  Thr Thr Ser Thr Thr  Ser Ala Pro 
    2435                 2440                 2445             


Pro Tyr  Gln Asn Gln Ser Thr  Cys Ala Val Tyr His  Arg Ser Leu 
    2450                 2455                 2460             


Ile Ile  Gln Gln Gln Gly Cys  Ser Ser Ser Glu Pro  Val Arg Leu 
    2465                 2470                 2475             


Ala Tyr  Cys Arg Gly Asn Cys  Gly Asp Ser Ser Ser  Met Tyr Ser 
    2480                 2485                 2490             


Leu Glu  Gly Asn Thr Val Glu  His Arg Cys Gln Cys  Cys Gln Glu 
    2495                 2500                 2505             


Leu Arg  Thr Ser Leu Arg Asn  Val Thr Leu His Cys  Thr Asp Gly 
    2510                 2515                 2520             


Ser Ser  Arg Ala Phe Ser Tyr  Thr Glu Val Glu Glu  Cys Gly Cys 
    2525                 2530                 2535             


Met Gly  Arg Arg Cys Pro Ala  Pro Gly Asp Thr Gln  His Ser Glu 
    2540                 2545                 2550             


Glu Ala  Glu Pro Glu Pro Ser  Gln Glu Ala Glu Ser  Gly Ser Trp 
    2555                 2560                 2565             


Glu Arg  Gly Val Pro Val Ser  Pro Met His 
    2570                 2575             


<210>  3
<211>  10437
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  pUC57-MUC5AC

<400>  3
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cgagctcggt acctcgcgaa      420

tgcatctaga tccaatgagc tcgccaccat gtcagtgggc aggagaaagc tcgccctgct      480

gtgggcactg gctctcgccc tcgcctgcac aaggcatacc ggtcatgccc aggacggaag      540

ttcagaatct tcctacaagc atcacccagc tctctcccct attgccagag gcccatcagg      600

cgtcccactc cggggcgcca ccgtgttccc ctctctgcgg accattcctg tggtgcgggc      660

atccaatcca gcccacaacg gtcgggtgtg ctccacttgg ggatctttcc attataagac      720

cttcgatggg gacgtgttcc gctttcctgg gctgtgtaac tacgtgtttt ccgagcattg      780

tggcgccgcc tacgaagatt tcaatatcca gctcaggcgg agccaggaaa gtgctgcccc      840

tacactgagc agggtcctca tgaaggtgga tggagtggtc attcagctga caaagggctc      900

agtgctggtc aacggacatc ccgtgctgct gcctttcagc cagtccggcg tcctgatcca      960

gcagtcaagt agctacacca aagtggaggc acggctcggc ctggtgctga tgtggaacca     1020

tgacgattca ctgctgctgg agctggatac caaatacgct aacaaaacct gtggcctgtg     1080

cggggacttc aatggaatgc cagtcgtgag cgagctgctc tctcacaata ccaagctgac     1140

ccctatggag tttggaaacc tgcagaagat ggacgaccca actgagcagt gccaggaccc     1200

cgtccctgag cctcccagga attgctctac aggcttcggg atttgcgagg agctgctgca     1260

cggccagctc ttttccggct gtgtcgccct cgtggatgtg gggagttatc tcgaagcctg     1320

ccgccaggac ctgtgctttt gtgaagacac agacctgctg tcctgtgtct gtcatacact     1380

ggctgaatat agtaggcagt gtacccatgc cggcgggctg ccacaggact ggagagggcc     1440

cgatttttgt ccacagaagt gtccaaataa tatgcagtac catgagtgta ggagtccctg     1500

tgctgatacc tgcagcaacc aggagcattc ccgggcttgt gaagaccatt gcgtggctgg     1560

atgtttctgc cctgagggaa ccgtgctgga tgatatcgga cagacaggct gtgtgcccgt     1620

ctctaaatgt gcctgtgtgt acaacggggc cgcctatgcc cccggtgcca cttactctac     1680

agattgcacc aattgcactt gcagtggggg aagatggtca tgccaggagg tcccctgccc     1740

tgatacttgc tctgtgctcg gtggcgcaca cttcagcaca tttgatggga agcagtatac     1800

cgtgcacggg gactgcagct acgtgctgac taaaccttgt gattcctcag cttttactgt     1860

gctggccgag ctgaggaggt gtggcctcac cgactccgaa acatgtctca aaagcgtcac     1920

tctgagtctc gacggtgctc agactgtcgt cgtgatcaaa gcatctggag aagtctttct     1980

caaccagatc tatacccagc tgcctatcag cgcagccaat gtcactatct ttaggccttc     2040

aaccttcttc attattgccc agacttccct cggactccag ctgaacctcc agcccgtgcc     2100

aactatgcag ctgttcatgc agctggcacc aaagctgcgc ggacagactt gcggcctgtg     2160

cggtaacttc aactccatcc aggccgatga ctttcggacc ctgtctggcg tcgtggaggc     2220

caccgctgca gctttcttca atactttcaa gactcaggca gcctgtccta atatccgaaa     2280

tagctttgaa gatccttgca gcctgtctgt ggagaacgag aaatacgccc agcattggtg     2340

cagccagctg accgacgccg atggcccatt cgggcggtgt cacgccgccg tgaagccagg     2400

cacttactat tccaattgtg tgttcgacac ctgcaactgc gagaggtccg aagattgtct     2460

ctgcgctgct ctgtccagct acgtgcatgc ttgtgccgct aaaggcgtcc agctgggggg     2520

gtggagagat ggagtgtgca ccaagccaat gacaacctgt cccaaaagca tgacatatca     2580

ctaccatgtg tctacatgtc agcctacttg taggagtctc agcgaagggg acatcacctg     2640

cagcgtcggg ttcatccccg tggatggatg tatttgtccc aagggcacct tcctggatga     2700

tacaggaaag tgcgtgcagg cctccaattg cccctgctac caccgggggt caatgattcc     2760

caacggagag tccgtccacg acagtggtgc aatttgcacc tgtactcacg gcaagctgag     2820

ttgcattggc ggtcaggctc ctgcaccagt gtgtgcagcc cccatggtgt tcttcgactg     2880

cagaaacgcc actcctgggg ataccggtgc cgggtgccag aagagctgcc atacactgga     2940

catgacttgt tactcacctc agtgtgtgcc cggatgtgtg tgccctgacg gcctcgtggc     3000

cgacggcgag ggagggtgta tcaccgcaga agattgtccc tgcgtccaca acgaagcctc     3060

atacagggcc ggacagacta tccgggtggg atgtaataca tgcacatgtg attctcggat     3120

gtggcggtgt accgatgacc catgcctcgc cacttgtgcc gtgtacggtg acggacacta     3180

cctgacattc gacggacaga gctatagttt caacggcgac tgcgagtaca cactggtgca     3240

gaatcactgc ggaggaaagg actcaaccca ggatagcttc cgcgtcgtga ccgagaatgt     3300

cccttgcgga accaccggaa ccacttgctc taaggccatc aagattttcc tgggcgggtt     3360

cgagctgaag ctgagccacg ggaaggtgga agtgattgga accgatgaat cccaggaggt     3420

gccctataca attcagcaga tgggcatcta cctcgtggtc gacacagata tcggtctggt     3480

gctgctctgg gacaagaaga cttctatctt cattaacctg agccccgagt tcaaaggacg     3540

cgtgtgtggc ctgtgcggca attttgatga cattgccgtc aatgactttg ccacccgctc     3600

tcgatcagtc gtgggagacg tgctggaatt cggaaactca tggaaactga gtcccagttg     3660

ccctgatgct ctggccccaa aagatccatg taccgctaac ccatttcgaa agagctgggc     3720

acagaagcag tgcagcatcc tgcatggacc cacctttgca gcctgtcacg cccacgtcga     3780

gcccgctagg tactacgagg catgtgtcaa tgatgcctgt gcctgcgact ccggtggaga     3840

ctgtgaatgc ttctgtaccg cagtggctgc ttacgcacag gcctgtcacg aggtcggcct     3900

gtgcgtctgt ctcagaaccc ccagtatctg tcctctcttt tgtgattact acaaccctga     3960

gggccagtgt gagtggcact accagccatg cggtgtgcct tgcctcagga catgtcgaaa     4020

tccccggggc gactgcctgc gcgacgtcag gggcctggag ggctgctacc ccaagtgccc     4080

tcccgaagcc cctatctttg atgaggacaa aatgcagtgt gtggctacct gtccaacacc     4140

acctctgcca cctaggtgtc atgtgcacgg aaaatcctat cgcccaggcg ctgtggtgcc     4200

ttccgataaa aattgccagt cctgtctgtg cacagagagg ggggtggagt gcacttacaa     4260

agccgaggcc tgtgtgtgca catacaacgg gcagcgcttt catcctggcg atgtgatcta     4320

tcacactaca gatgggaccg gcggatgtat ttccgcccgg tgtggagcta acggaactat     4380

tgaaagaagg gtgtacccct gttctccaac aactccagtg cctcctacta cctttagctt     4440

ttccactcct cccctggtgg tgtcttccac tcataccccc agtaatgggc cctccagcgc     4500

ccacaccgga ccaccaagct ctgcctggcc aacaacagcc ggcacatctc ctagaactag     4560

gctgcctact gctagtgcct ctctgcctcc cgtgtgcggc gagaagtgcc tgtggagccc     4620

atggatggac gtgagtagac caggcagggg aactgacagt ggagatttcg acaccctgga     4680

aaatctgaga gcccacggat accgggtgtg tgagagtccc cgcagcgtgg agtgtcgggc     4740

cgaggacgcc cccggggtgc ctctgcgcgc cctgggacag agagtgcagt gtagcccaga     4800

cgtgggcctg acttgtagaa atagagagca ggctagcgga ctgtgctata actaccagat     4860

tagagtgcag tgctgtactc cactgccctg cagcaccagc tccagtcccg cccagacaac     4920

ccctcctaca acaagtaaaa ctacagagac tagggcttcc ggaagttctg ccccctccag     4980

cacccccggc acagtgtccc tgagtaccgc ccgcacaacc cccgccccag gcacagccac     5040

cagcgtgaag aaaaccttta gcacaccttc tccccccccc gtgccagcca catccacctc     5100

cagcatgagc actaccgccc ccggcacctc cgtggtgagt tccaagccta ctcccacaga     5160

acccagtaca agctcttgcc tgcaggaact gtgtacatgg actgagtgga tcgacggctc     5220

ctaccctgcc cctggaatca atggcggaga ttttgacacc tttcagaacc tgagagacga     5280

gggctacaca ttttgcgaga gccctcgcag cgtgcagtgc cgggccgagt ctttccctaa     5340

tacccctctg gccgacctgg gacaggacgt gatctgttcc cacactgaag ggctgatctg     5400

cctgaataag aaccagctgc ctccaatctg ttacaactat gagattcgca tccagtgctg     5460

cgagaccgtg aacgtgtgta gggacattac ccggctgcca aaaacagtgg ccacaactcg     5520

ccccacccct catcctaccg gcgcccagac acagacaact ttcactacac atatgccttc     5580

tgccagtacc gaacagccaa cagccacaag cagagggggc ccaaccgcca catctgtgac     5640

ccagggcacc catactactc tggtgactcg gaactgccac ccccggtgca cttggactaa     5700

gtggtttgac gtggattttc cctctcctgg ccctcatggg ggcgacaaag aaacctataa     5760

caacatcatt cgctctggcg agaaaatttg caggagacca gaagaaatta caagagtgca     5820

gtgtagagct aaaagccacc cagaagtgtc catcgagcac ctgggccagg tggtgcagtg     5880

ttctcgggag gagggcctgg tgtgcaggaa ccaggaccag cagggaccat tcaagatgtg     5940

tctgaattat gaggtgagag tgctgtgctg cgagactcct aggggatgcc acatgacctc     6000

tacccctggc tccacaagtt ctagccctgc tcagacaacc cccagcacaa catctaagac     6060

tactgagatc caggcctccg gcagctctgc cccctccagt actcccggca cagtgagcct     6120

gtccactgcc aggactaccc ccgcccctgg cactgccaca tctgtgaaga agacctttag     6180

tactccttcc ccccctcctg tgcctgctac ctccacatcc agtatgtcca ctaccgctcc     6240

aggaacttcc gtggtgtcct ccaaaccaac tcccactgag ccaagcacta gcagttgtct     6300

gcaggagctg tgtacctgga ctgaatggat tgacggaagc taccctgccc ctggaattaa     6360

tgggggggat tttgatacct tccagaatct gagagatgag ggatacactt tttgtgaaag     6420

tccacggtcc gtgcagtgta gggccgaaag ctttcctaac acccctctgg ggagactggg     6480

ccaggatgtg atctgcagcc atactgaggg cctgatctgc ctgaacaaga atcagctgcc     6540

cccaatttgc tacaattacg agattcggat ccagtgctgc gaaactgtga atgtgtgtag     6600

agatatcaca aggccaccta aaaccgtggc tacaacaagg cccaccccac acccaactgg     6660

cgcccagacc cagaccacat tcacaacaca catgccctcc gctagtaccg agcagcccac     6720

cgccacctcc aggggaggcc caaccgccac ttccgtgaca cagggcaccc acaccactcc     6780

agtgacaaga aattgccatc ctcgctgcac ttggactaca tggtttgatg tggatttccc     6840

aagtcccgga ccccatgggg gggacaaaga gacttataat aatattatca ggagcggcga     6900

aaagatctgc aggcgcccag aggagatcac aagactgcag tgtcgggcta agtcccatcc     6960

tgaggtgagc attgagcacc tgggacaggt ggtgcagtgt tctagggagg aaggcctggt     7020

gtgcagaaac caggaccagc aggggccttt caaaatgtgc ctgaatatcg aagtgagagt     7080

gctgtgttgt gaaactccaa aaggctgccc tgtgactagc acccctgtga ccgctccttc     7140

cacacccagc gggagagcca ttagtccaac acagtctaca agctcctggc agaagtctcg     7200

cacaaccact ctggtgacca cctctacaac atccacccct cagacaagca ccacctacgc     7260

tcacacaacc agcactacta gcgcccccac agctcgcaca accagtgccc ctacaaccag     7320

cacaacaagt gtgcccacaa cctccaccat ttccggacct aaaacaaccc caagcccagt     7380

gccaacaacc tccacaacct ccgctgccac taccagcaca attagcgccc caactacaag     7440

tactacaagc gtgcccggga caaccccatc tcctgtgctg accacttcca ccaccagtgc     7500

tcccacaact cggaccacct ccgcctcccc cgctgggact acatctggcc caggaaatac     7560

acccagcccc gtgccaacca cttctactat ctccgccccc acaacatcta ttacctctgc     7620

cccaaccacc tctaccactt ccgctcccac atcctctact acttccgggc ccggcaccac     7680

cccttcccca gtgccaacta catccattac aagtgctcca accacttcta ccactagtgc     7740

tcctacaacc agcactacct ccgctccaac cacaagtaca acctccgccc ccccttacca     7800

gaaccagagc acatgtgctg tgtatcatcg gagtctgatt atccagcagc agggctgttc     7860

tagcagcgaa cccgtgagac tggcctactg caggggcaat tgtggcgata gttcctccat     7920

gtatagtctg gaaggcaata ctgtggagca ccgctgtcag tgctgtcagg agctgagaac     7980

atctctgagg aatgtgactc tgcactgtac cgacggcagc agcagagcct ttagctacac     8040

tgaagtggag gagtgcgggt gcatggggag aagatgccct gcccccggag acacacagca     8100

tagtgaggaa gccgagcctg aacctagcca ggaagccgaa tctggcagtt gggagagagg     8160

agtgcctgtg tcccctatgc attgataata gagctcaaag cttggcgtaa tcatggtcat     8220

agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata cgagccggaa     8280

gcataaagtg taaagcctgg ggtgcctaat gagtgagcta actcacatta attgcgttgc     8340

gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc     8400

aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact     8460

cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag gcggtaatac     8520

ggttatccac agaatcaggg gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa     8580

aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc cgcccccctg     8640

acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca ggactataaa     8700

gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg accctgccgc     8760

ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct catagctcac     8820

gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac     8880

cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag tccaacccgg     8940

taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc agagcgaggt     9000

atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac actagaagaa     9060

cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga gttggtagct     9120

cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc aagcagcaga     9180

ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg gggtctgacg     9240

ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca aaaaggatct     9300

tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt     9360

aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca gcgatctgtc     9420

tatttcgttc atccatagtt gcctgactcc ccgtcgtgta gataactacg atacgggagg     9480

gcttaccatc tggccccagt gctgcaatga taccgcgaga cccacgctca ccggctccag     9540

atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt cctgcaactt     9600

tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt agttcgccag     9660

ttaatagttt gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt     9720

ttggtatggc ttcattcagc tccggttccc aacgatcaag gcgagttaca tgatccccca     9780

tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat cgttgtcaga agtaagttgg     9840

ccgcagtgtt atcactcatg gttatggcag cactgcataa ttctcttact gtcatgccat     9900

ccgtaagatg cttttctgtg actggtgagt actcaaccaa gtcattctga gaatagtgta     9960

tgcggcgacc gagttgctct tgcccggcgt caatacggga taataccgcg ccacatagca    10020

gaactttaaa agtgctcatc attggaaaac gttcttcggg gcgaaaactc tcaaggatct    10080

taccgctgtt gagatccagt tcgatgtaac ccactcgtgc acccaactga tcttcagcat    10140

cttttacttt caccagcgtt tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa    10200

agggaataag ggcgacacgg aaatgttgaa tactcatact cttccttttt caatattatt    10260

gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa    10320

ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgac gtctaagaaa    10380

ccattattat catgacatta acctataaaa ataggcgtat cacgaggccc tttcgtc       10437


<210>  4
<211>  13061
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  pIRES2-AcGFP1-MUC5AC-280

<400>  4
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctgg tttagtgaac cgtcagatcc gctagcgcta      600

ccggactcag atctcgagct cgccaccatg tcagtgggca ggagaaagct cgccctgctg      660

tgggcactgg ctctcgccct cgcctgcaca aggcataccg gtcatgccca ggacggaagt      720

tcagaatctt cctacaagca tcacccagct ctctccccta ttgccagagg cccatcaggc      780

gtcccactcc ggggcgccac cgtgttcccc tctctgcgga ccattcctgt ggtgcgggca      840

tccaatccag cccacaacgg tcgggtgtgc tccacttggg gatctttcca ttataagacc      900

ttcgatgggg acgtgttccg ctttcctggg ctgtgtaact acgtgttttc cgagcattgt      960

ggcgccgcct acgaagattt caatatccag ctcaggcgga gccaggaaag tgctgcccct     1020

acactgagca gggtcctcat gaaggtggat ggagtggtca ttcagctgac aaagggctca     1080

gtgctggtca acggacatcc cgtgctgctg cctttcagcc agtccggcgt cctgatccag     1140

cagtcaagta gctacaccaa agtggaggca cggctcggcc tggtgctgat gtggaaccat     1200

gacgattcac tgctgctgga gctggatacc aaatacgcta acaaaacctg tggcctgtgc     1260

ggggacttca atggaatgcc agtcgtgagc gagctgctct ctcacaatac caagctgacc     1320

cctatggagt ttggaaacct gcagaagatg gacgacccaa ctgagcagtg ccaggacccc     1380

gtccctgagc ctcccaggaa ttgctctaca ggcttcggga tttgcgagga gctgctgcac     1440

ggccagctct tttccggctg tgtcgccctc gtggatgtgg ggagttatct cgaagcctgc     1500

cgccaggacc tgtgcttttg tgaagacaca gacctgctgt cctgtgtctg tcatacactg     1560

gctgaatata gtaggcagtg tacccatgcc ggcgggctgc cacaggactg gagagggccc     1620

gatttttgtc cacagaagtg tccaaataat atgcagtacc atgagtgtag gagtccctgt     1680

gctgatacct gcagcaacca ggagcattcc cgggcttgtg aagaccattg cgtggctgga     1740

tgtttctgcc ctgagggaac cgtgctggat gatatcggac agacaggctg tgtgcccgtc     1800

tctaaatgtg cctgtgtgta caacggggcc gcctatgccc ccggtgccac ttactctaca     1860

gattgcacca attgcacttg cagtggggga agatggtcat gccaggaggt cccctgccct     1920

gatacttgct ctgtgctcgg tggcgcacac ttcagcacat ttgatgggaa gcagtatacc     1980

gtgcacgggg actgcagcta cgtgctgact aaaccttgtg attcctcagc ttttactgtg     2040

ctggccgagc tgaggaggtg tggcctcacc gactccgaaa catgtctcaa aagcgtcact     2100

ctgagtctcg acggtgctca gactgtcgtc gtgatcaaag catctggaga agtctttctc     2160

aaccagatct atacccagct gcctatcagc gcagccaatg tcactatctt taggccttca     2220

accttcttca ttattgccca gacttccctc ggactccagc tgaacctcca gcccgtgcca     2280

actatgcagc tgttcatgca gctggcacca aagctgcgcg gacagacttg cggcctgtgc     2340

ggtaacttca actccatcca ggccgatgac tttcggaccc tgtctggcgt cgtggaggcc     2400

accgctgcag ctttcttcaa tactttcaag actcaggcag cctgtcctaa tatccgaaat     2460

agctttgaag atccttgcag cctgtctgtg gagaacgaga aatacgccca gcattggtgc     2520

agccagctga ccgacgccga tggcccattc gggcggtgtc acgccgccgt gaagccaggc     2580

acttactatt ccaattgtgt gttcgacacc tgcaactgcg agaggtccga agattgtctc     2640

tgcgctgctc tgtccagcta cgtgcatgct tgtgccgcta aaggcgtcca gctggggggg     2700

tggagagatg gagtgtgcac caagccaatg acaacctgtc ccaaaagcat gacatatcac     2760

taccatgtgt ctacatgtca gcctacttgt aggagtctca gcgaagggga catcacctgc     2820

agcgtcgggt tcatccccgt ggatggatgt atttgtccca agggcacctt cctggatgat     2880

acaggaaagt gcgtgcaggc ctccaattgc ccctgctacc accgggggtc aatgattccc     2940

aacggagagt ccgtccacga cagtggtgca atttgcacct gtactcacgg caagctgagt     3000

tgcattggcg gtcaggctcc tgcaccagtg tgtgcagccc ccatggtgtt cttcgactgc     3060

agaaacgcca ctcctgggga taccggtgcc gggtgccaga agagctgcca tacactggac     3120

atgacttgtt actcacctca gtgtgtgccc ggatgtgtgt gccctgacgg cctcgtggcc     3180

gacggcgagg gagggtgtat caccgcagaa gattgtccct gcgtccacaa cgaagcctca     3240

tacagggccg gacagactat ccgggtggga tgtaatacat gcacatgtga ttctcggatg     3300

tggcggtgta ccgatgaccc atgcctcgcc acttgtgccg tgtacggtga cggacactac     3360

ctgacattcg acggacagag ctatagtttc aacggcgact gcgagtacac actggtgcag     3420

aatcactgcg gaggaaagga ctcaacccag gatagcttcc gcgtcgtgac cgagaatgtc     3480

ccttgcggaa ccaccggaac cacttgctct aaggccatca agattttcct gggcgggttc     3540

gagctgaagc tgagccacgg gaaggtggaa gtgattggaa ccgatgaatc ccaggaggtg     3600

ccctatacaa ttcagcagat gggcatctac ctcgtggtcg acacagatat cggtctggtg     3660

ctgctctggg acaagaagac ttctatcttc attaacctga gccccgagtt caaaggacgc     3720

gtgtgtggcc tgtgcggcaa ttttgatgac attgccgtca atgactttgc cacccgctct     3780

cgatcagtcg tgggagacgt gctggaattc ggaaactcat ggaaactgag tcccagttgc     3840

cctgatgctc tggccccaaa agatccatgt accgctaacc catttcgaaa gagctgggca     3900

cagaagcagt gcagcatcct gcatggaccc acctttgcag cctgtcacgc ccacgtcgag     3960

cccgctaggt actacgaggc atgtgtcaat gatgcctgtg cctgcgactc cggtggagac     4020

tgtgaatgct tctgtaccgc agtggctgct tacgcacagg cctgtcacga ggtcggcctg     4080

tgcgtctgtc tcagaacccc cagtatctgt cctctctttt gtgattacta caaccctgag     4140

ggccagtgtg agtggcacta ccagccatgc ggtgtgcctt gcctcaggac atgtcgaaat     4200

ccccggggcg actgcctgcg cgacgtcagg ggcctggagg gctgctaccc caagtgccct     4260

cccgaagccc ctatctttga tgaggacaaa atgcagtgtg tggctacctg tccaacacca     4320

cctctgccac ctaggtgtca tgtgcacgga aaatcctatc gcccaggcgc tgtggtgcct     4380

tccgataaaa attgccagtc ctgtctgtgc acagagaggg gggtggagtg cacttacaaa     4440

gccgaggcct gtgtgtgcac atacaacggg cagcgctttc atcctggcga tgtgatctat     4500

cacactacag atgggaccgg cggatgtatt tccgcccggt gtggagctaa cggaactatt     4560

gaaagaaggg tgtacccctg ttctccaaca actccagtgc ctcctactac ctttagcttt     4620

tccactcctc ccctggtggt gtcttccact cataccccca gtaatgggcc ctccagcgcc     4680

cacaccggac caccaagctc tgcctggcca acaacagccg gcacatctcc tagaactagg     4740

ctgcctactg ctagtgcctc tctgcctccc gtgtgcggcg agaagtgcct gtggagccca     4800

tggatggacg tgagtagacc aggcagggga actgacagtg gagatttcga caccctggaa     4860

aatctgagag cccacggata ccgggtgtgt gagagtcccc gcagcgtgga gtgtcgggcc     4920

gaggacgccc ccggggtgcc tctgcgcgcc ctgggacaga gagtgcagtg tagcccagac     4980

gtgggcctga cttgtagaaa tagagagcag gctagcggac tgtgctataa ctaccagatt     5040

agagtgcagt gctgtactcc actgccctgc agcaccagct ccagtcccgc ccagacaacc     5100

cctcctacaa caagtaaaac tacagagact agggcttccg gaagttctgc cccctccagc     5160

acccccggca cagtgtccct gagtaccgcc cgcacaaccc ccgccccagg cacagccacc     5220

agcgtgaaga aaacctttag cacaccttct cccccccccg tgccagccac atccacctcc     5280

agcatgagca ctaccgcccc cggcacctcc gtggtgagtt ccaagcctac tcccacagaa     5340

cccagtacaa gctcttgcct gcaggaactg tgtacatgga ctgagtggat cgacggctcc     5400

taccctgccc ctggaatcaa tggcggagat tttgacacct ttcagaacct gagagacgag     5460

ggctacacat tttgcgagag ccctcgcagc gtgcagtgcc gggccgagtc tttccctaat     5520

acccctctgg ccgacctggg acaggacgtg atctgttccc acactgaagg gctgatctgc     5580

ctgaataaga accagctgcc tccaatctgt tacaactatg agattcgcat ccagtgctgc     5640

gagaccgtga acgtgtgtag ggacattacc cggctgccaa aaacagtggc cacaactcgc     5700

cccacccctc atcctaccgg cgcccagaca cagacaactt tcactacaca tatgccttct     5760

gccagtaccg aacagccaac agccacaagc agagggggcc caaccgccac atctgtgacc     5820

cagggcaccc atactactct ggtgactcgg aactgccacc cccggtgcac ttggactaag     5880

tggtttgacg tggattttcc ctctcctggc cctcatgggg gcgacaaaga aacctataac     5940

aacatcattc gctctggcga gaaaatttgc aggagaccag aagaaattac aagagtgcag     6000

tgtagagcta aaagccaccc agaagtgtcc atcgagcacc tgggccaggt ggtgcagtgt     6060

tctcgggagg agggcctggt gtgcaggaac caggaccagc agggaccatt caagatgtgt     6120

ctgaattatg aggtgagagt gctgtgctgc gagactccta ggggatgcca catgacctct     6180

acccctggct ccacaagttc tagccctgct cagacaaccc ccagcacaac atctaagact     6240

actgagatcc aggcctccgg cagctctgcc ccctccagta ctcccggcac agtgagcctg     6300

tccactgcca ggactacccc cgcccctggc actgccacat ctgtgaagaa gacctttagt     6360

actccttccc cccctcctgt gcctgctacc tccacatcca gtatgtccac taccgctcca     6420

ggaacttccg tggtgtcctc caaaccaact cccactgagc caagcactag cagttgtctg     6480

caggagctgt gtacctggac tgaatggatt gacggaagct accctgcccc tggaattaat     6540

gggggggatt ttgatacctt ccagaatctg agagatgagg gatacacttt ttgtgaaagt     6600

ccacggtccg tgcagtgtag ggccgaaagc tttcctaaca cccctctggg gagactgggc     6660

caggatgtga tctgcagcca tactgagggc ctgatctgcc tgaacaagaa tcagctgccc     6720

ccaatttgct acaattacga gattcggatc cagtgctgcg aaactgtgaa tgtgtgtaga     6780

gatatcacaa ggccacctaa aaccgtggct acaacaaggc ccaccccaca cccaactggc     6840

gcccagaccc agaccacatt cacaacacac atgccctccg ctagtaccga gcagcccacc     6900

gccacctcca ggggaggccc aaccgccact tccgtgacac agggcaccca caccactcca     6960

gtgacaagaa attgccatcc tcgctgcact tggactacat ggtttgatgt ggatttccca     7020

agtcccggac cccatggggg ggacaaagag acttataata atattatcag gagcggcgaa     7080

aagatctgca ggcgcccaga ggagatcaca agactgcagt gtcgggctaa gtcccatcct     7140

gaggtgagca ttgagcacct gggacaggtg gtgcagtgtt ctagggagga aggcctggtg     7200

tgcagaaacc aggaccagca ggggcctttc aaaatgtgcc tgaatatcga agtgagagtg     7260

ctgtgttgtg aaactccaaa aggctgccct gtgactagca cccctgtgac cgctccttcc     7320

acacccagcg ggagagccat tagtccaaca cagtctacaa gctcctggca gaagtctcgc     7380

acaaccactc tggtgaccac ctctacaaca tccacccctc agacaagcac cacctacgct     7440

cacacaacca gcactactag cgcccccaca gctcgcacaa ccagtgcccc tacaaccagc     7500

acaacaagtg tgcccacaac ctccaccatt tccggaccta aaacaacccc aagcccagtg     7560

ccaacaacct ccacaacctc cgctgccact accagcacaa ttagcgcccc aactacaagt     7620

actacaagcg tgcccgggac aaccccatct cctgtgctga ccacttccac caccagtgct     7680

cccacaactc ggaccacctc cgcctccccc gctgggacta catctggccc aggaaataca     7740

cccagccccg tgccaaccac ttctactatc tccgccccca caacatctat tacctctgcc     7800

ccaaccacct ctaccacttc cgctcccaca tcctctacta cttccgggcc cggcaccacc     7860

ccttccccag tgccaactac atccattaca agtgctccaa ccacttctac cactagtgct     7920

cctacaacca gcactacctc cgctccaacc acaagtacaa cctccgcccc cccttaccag     7980

aaccagagca catgtgctgt gtatcatcgg agtctgatta tccagcagca gggctgttct     8040

agcagcgaac ccgtgagact ggcctactgc aggggcaatt gtggcgatag ttcctccatg     8100

tatagtctgg aaggcaatac tgtggagcac cgctgtcagt gctgtcagga gctgagaaca     8160

tctctgagga atgtgactct gcactgtacc gacggcagca gcagagcctt tagctacact     8220

gaagtggagg agtgcgggtg catggggaga agatgccctg cccccggaga cacacagcat     8280

agtgaggaag ccgagcctga acctagccag gaagccgaat ctggcagttg ggagagagga     8340

gtgcctgtgt cccctatgca ttgataatag agctcaagct tcgaattctg cagtcgacgg     8400

taccgcgggc ccgggatccg cccctctccc tccccccccc ctaacgttac tggccgaagc     8460

cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat attgccgtct     8520

tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat tcctaggggt     8580

ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct     8640

ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca gcggaacccc     8700

ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac acctgcaaag     8760

gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt caaatggctc     8820

tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca ttgtatggga     8880

tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt     8940

ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg ataatatggc     9000

cacaaccatg gtgagcaagg gcgccgagct gttcaccggc atcgtgccca tcctgatcga     9060

gctgaatggc gatgtgaatg gccacaagtt cagcgtgagc ggcgagggcg agggcgatgc     9120

cacctacggc aagctgaccc tgaagttcat ctgcaccacc ggcaagctgc ctgtgccctg     9180

gcccaccctg gtgaccaccc tgagctacgg cgtgcagtgc ttctcacgct accccgatca     9240

catgaagcag cacgacttct tcaagagcgc catgcctgag ggctacatcc aggagcgcac     9300

catcttcttc gaggatgacg gcaactacaa gtcgcgcgcc gaggtgaagt tcgagggcga     9360

taccctggtg aatcgcatcg agctgaccgg caccgatttc aaggaggatg gcaacatcct     9420

gggcaataag atggagtaca actacaacgc ccacaatgtg tacatcatga ccgacaaggc     9480

caagaatggc atcaaggtga acttcaagat ccgccacaac atcgaggatg gcagcgtgca     9540

gctggccgac cactaccagc agaatacccc catcggcgat ggccctgtgc tgctgcccga     9600

taaccactac ctgtccaccc agagcgccct gtccaaggac cccaacgaga agcgcgatca     9660

catgatctac ttcggcttcg tgaccgccgc cgccatcacc cacggcatgg atgagctgta     9720

caagtgagcg gccgcgactc tagatcataa tcagccatac cacatttgta gaggttttac     9780

ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg     9840

ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa     9900

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca     9960

atgtatctta aggcgtaaat tgtaagcgtt aatattttgt taaaattcgc gttaaatttt    10020

tgttaaatca gctcattttt taaccaatag gccgaaatcg gcaaaatccc ttataaatca    10080

aaagaataga ccgagatagg gttgagtgtt gttccagttt ggaacaagag tccactatta    10140

aagaacgtgg actccaacgt caaagggcga aaaaccgtct atcagggcga tggcccacta    10200

cgtgaaccat caccctaatc aagttttttg gggtcgaggt gccgtaaagc actaaatcgg    10260

aaccctaaag ggagcccccg atttagagct tgacggggaa agccggcgaa cgtggcgaga    10320

aaggaaggga agaaagcgaa aggagcgggc gctagggcgc tggcaagtgt agcggtcacg    10380

ctgcgcgtaa ccaccacacc cgccgcgctt aatgcgccgc tacagggcgc gtcaggtggc    10440

acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat    10500

atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag    10560

agtcctgagg cggaaagaac cagctgtgga atgtgtgtca gttagggtgt ggaaagtccc    10620

caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca gcaaccaggt    10680

gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat ctcaattagt    10740

cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg cccagttccg    10800

cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc gaggccgcct    10860

cggcctctga gctattccag aagtagtgag gaggcttttt tggaggccta ggcttttgca    10920

aagatcgatc aagagacagg atgaggatcg tttcgcatga ttgaacaaga tggattgcac    10980

gcaggttctc cggccgcttg ggtggagagg ctattcggct atgactgggc acaacagaca    11040

atcggctgct ctgatgccgc cgtgttccgg ctgtcagcgc aggggcgccc ggttcttttt    11100

gtcaagaccg acctgtccgg tgccctgaat gaactgcaag acgaggcagc gcggctatcg    11160

tggctggcca cgacgggcgt tccttgcgca gctgtgctcg acgttgtcac tgaagcggga    11220

agggactggc tgctattggg cgaagtgccg gggcaggatc tcctgtcatc tcaccttgct    11280

cctgccgaga aagtatccat catggctgat gcaatgcggc ggctgcatac gcttgatccg    11340

gctacctgcc cattcgacca ccaagcgaaa catcgcatcg agcgagcacg tactcggatg    11400

gaagccggtc ttgtcgatca ggatgatctg gacgaagagc atcaggggct cgcgccagcc    11460

gaactgttcg ccaggctcaa ggcgagcatg cccgacggcg aggatctcgt cgtgacccat    11520

ggcgatgcct gcttgccgaa tatcatggtg gaaaatggcc gcttttctgg attcatcgac    11580

tgtggccggc tgggtgtggc ggaccgctat caggacatag cgttggctac ccgtgatatt    11640

gctgaagagc ttggcggcga atgggctgac cgcttcctcg tgctttacgg tatcgccgct    11700

cccgattcgc agcgcatcgc cttctatcgc cttcttgacg agttcttctg agcgggactc    11760

tggggttcga aatgaccgac caagcgacgc ccaacctgcc atcacgagat ttcgattcca    11820

ccgccgcctt ctatgaaagg ttgggcttcg gaatcgtttt ccgggacgcc ggctggatga    11880

tcctccagcg cggggatctc atgctggagt tcttcgccca ccctaggggg aggctaactg    11940

aaacacggaa ggagacaata ccggaaggaa cccgcgctat gacggcaata aaaagacaga    12000

ataaaacgca cggtgttggg tcgtttgttc ataaacgcgg ggttcggtcc cagggctggc    12060

actctgtcga taccccaccg agaccccatt ggggccaata cgcccgcgtt tcttcctttt    12120

ccccacccca ccccccaagt tcgggtgaag gcccagggct cgcagccaac gtcggggcgg    12180

caggccctgc catagcctca ggttactcat atatacttta gattgattta aaacttcatt    12240

tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt    12300

aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt    12360

gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag    12420

cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca    12480

gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca    12540

agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg    12600

ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg    12660

cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct    12720

acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga    12780

gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc    12840

ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg    12900

agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg    12960

cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt    13020

tatcccctga ttctgtggat aaccgtatta ccgccatgca t                        13061


<210>  5
<211>  21
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  Cebador MAO151

<400>  5
gtaggcgtgt acggtgggag g                                                 21


<210>  6
<211>  23
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  Cebador MAO153

<400>  6
ccttattcca agcggcttcg gcc                                               23


<210>  7
<211>  11702
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  pMUCIN5AC-29

<400>  7
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctgg tttagtgaac cgtcagatcc gctagcgcta      600

ccggactcag atctcgagct cgccaccatg tcagtgggca ggagaaagct cgccctgctg      660

tgggcactgg ctctcgccct cgcctgcaca aggcataccg gtcatgccca ggacggaagt      720

tcagaatctt cctacaagca tcacccagct ctctccccta ttgccagagg cccatcaggc      780

gtcccactcc ggggcgccac cgtgttcccc tctctgcgga ccattcctgt ggtgcgggca      840

tccaatccag cccacaacgg tcgggtgtgc tccacttggg gatctttcca ttataagacc      900

ttcgatgggg acgtgttccg ctttcctggg ctgtgtaact acgtgttttc cgagcattgt      960

ggcgccgcct acgaagattt caatatccag ctcaggcgga gccaggaaag tgctgcccct     1020

acactgagca gggtcctcat gaaggtggat ggagtggtca ttcagctgac aaagggctca     1080

gtgctggtca acggacatcc cgtgctgctg cctttcagcc agtccggcgt cctgatccag     1140

cagtcaagta gctacaccaa agtggaggca cggctcggcc tggtgctgat gtggaaccat     1200

gacgattcac tgctgctgga gctggatacc aaatacgcta acaaaacctg tggcctgtgc     1260

ggggacttca atggaatgcc agtcgtgagc gagctgctct ctcacaatac caagctgacc     1320

cctatggagt ttggaaacct gcagaagatg gacgacccaa ctgagcagtg ccaggacccc     1380

gtccctgagc ctcccaggaa ttgctctaca ggcttcggga tttgcgagga gctgctgcac     1440

ggccagctct tttccggctg tgtcgccctc gtggatgtgg ggagttatct cgaagcctgc     1500

cgccaggacc tgtgcttttg tgaagacaca gacctgctgt cctgtgtctg tcatacactg     1560

gctgaatata gtaggcagtg tacccatgcc ggcgggctgc cacaggactg gagagggccc     1620

gatttttgtc cacagaagtg tccaaataat atgcagtacc atgagtgtag gagtccctgt     1680

gctgatacct gcagcaacca ggagcattcc cgggcttgtg aagaccattg cgtggctgga     1740

tgtttctgcc ctgagggaac cgtgctggat gatatcggac agacaggctg tgtgcccgtc     1800

tctaaatgtg cctgtgtgta caacggggcc gcctatgccc ccggtgccac ttactctaca     1860

gattgcacca attgcacttg cagtggggga agatggtcat gccaggaggt cccctgccct     1920

gatacttgct ctgtgctcgg tggcgcacac ttcagcacat ttgatgggaa gcagtatacc     1980

gtgcacgggg actgcagcta cgtgctgact aaaccttgtg attcctcagc ttttactgtg     2040

ctggccgagc tgaggaggtg tggcctcacc gactccgaaa catgtctcaa aagcgtcact     2100

ctgagtctcg acggtgctca gactgtcgtc gtgatcaaag catctggaga agtctttctc     2160

aaccagatct atacccagct gcctatcagc gcagccaatg tcactatctt taggccttca     2220

accttcttca ttattgccca gacttccctc ggactccagc tgaacctcca gcccgtgcca     2280

actatgcagc tgttcatgca gctggcacca aagctgcgcg gacagacttg cggcctgtgc     2340

ggtaacttca actccatcca ggccgatgac tttcggaccc tgtctggcgt cgtggaggcc     2400

accgctgcag ctttcttcaa tactttcaag actcaggcag cctgtcctaa tatccgaaat     2460

agctttgaag atccttgcag cctgtctgtg gagaacgaga aatacgccca gcattggtgc     2520

agccagctga ccgacgccga tggcccattc gggcggtgtc acgccgccgt gaagccaggc     2580

acttactatt ccaattgtgt gttcgacacc tgcaactgcg agaggtccga agattgtctc     2640

tgcgctgctc tgtccagcta cgtgcatgct tgtgccgcta aaggcgtcca gctggggggg     2700

tggagagatg gagtgtgcac caagccaatg acaacctgtc ccaaaagcat gacatatcac     2760

taccatgtgt ctacatgtca gcctacttgt aggagtctca gcgaagggga catcacctgc     2820

agcgtcgggt tcatccccgt ggatggatgt atttgtccca agggcacctt cctggatgat     2880

acaggaaagt gcgtgcaggc ctccaattgc ccctgctacc accgggggtc aatgattccc     2940

aacggagagt ccgtccacga cagtggtgca atttgcacct gtactcacgg caagctgagt     3000

tgcattggcg gtcaggctcc tgcaccagtg tgtgcagccc ccatggtgtt cttcgactgc     3060

agaaacgcca ctcctgggga taccggtgcc gggtgccaga agagctgcca tacactggac     3120

atgacttgtt actcacctca gtgtgtgccc ggatgtgtgt gccctgacgg cctcgtggcc     3180

gacggcgagg gagggtgtat caccgcagaa gattgtccct gcgtccacaa cgaagcctca     3240

tacagggccg gacagactat ccgggtggga tgtaatacat gcacatgtga ttctcggatg     3300

tggcggtgta ccgatgaccc atgcctcgcc acttgtgccg tgtacggtga cggacactac     3360

ctgacattcg acggacagag ctatagtttc aacggcgact gcgagtacac actggtgcag     3420

aatcactgcg gaggaaagga ctcaacccag gatagcttcc gcgtcgtgac cgagaatgtc     3480

ccttgcggaa ccaccggaac cacttgctct aaggccatca agattttcct gggcgggttc     3540

gagctgaagc tgagccacgg gaaggtggaa gtgattggaa ccgatgaatc ccaggaggtg     3600

ccctatacaa ttcagcagat gggcatctac ctcgtggtcg acacagatat cggtctggtg     3660

ctgctctggg acaagaagac ttctatcttc attaacctga gccccgagtt caaaggacgc     3720

gtgtgtggcc tgtgcggcaa ttttgatgac attgccgtca atgactttgc cacccgctct     3780

cgatcagtcg tgggagacgt gctggaattc ggaaactcat ggaaactgag tcccagttgc     3840

cctgatgctc tggccccaaa agatccatgt accgctaacc catttcgaaa gagctgggca     3900

cagaagcagt gcagcatcct gcatggaccc acctttgcag cctgtcacgc ccacgtcgag     3960

cccgctaggt actacgaggc atgtgtcaat gatgcctgtg cctgcgactc cggtggagac     4020

tgtgaatgct tctgtaccgc agtggctgct tacgcacagg cctgtcacga ggtcggcctg     4080

tgcgtctgtc tcagaacccc cagtatctgt cctctctttt gtgattacta caaccctgag     4140

ggccagtgtg agtggcacta ccagccatgc ggtgtgcctt gcctcaggac atgtcgaaat     4200

ccccggggcg actgcctgcg cgacgtcagg ggcctggagg gctgctaccc caagtgccct     4260

cccgaagccc ctatctttga tgaggacaaa atgcagtgtg tggctacctg tccaacacca     4320

cctctgccac ctaggtgtca tgtgcacgga aaatcctatc gcccaggcgc tgtggtgcct     4380

tccgataaaa attgccagtc ctgtctgtgc acagagaggg gggtggagtg cacttacaaa     4440

gccgaggcct gtgtgtgcac atacaacggg cagcgctttc atcctggcga tgtgatctat     4500

cacactacag atgggaccgg cggatgtatt tccgcccggt gtggagctaa cggaactatt     4560

gaaagaaggg tgtacccctg ttctccaaca actccagtgc ctcctactac ctttagcttt     4620

tccactcctc ccctggtggt gtcttccact cataccccca gtaatgggcc ctccagcgcc     4680

cacaccggac caccaagctc tgcctggcca acaacagccg gcacatctcc tagaactagg     4740

ctgcctactg ctagtgcctc tctgcctccc gtgtgcggcg agaagtgcct gtggagccca     4800

tggatggacg tgagtagacc aggcagggga actgacagtg gagatttcga caccctggaa     4860

aatctgagag cccacggata ccgggtgtgt gagagtcccc gcagcgtgga gtgtcgggcc     4920

gaggacgccc ccggggtgcc tctgcgcgcc ctgggacaga gagtgcagtg tagcccagac     4980

gtgggcctga cttgtagaaa tagagagcag gctagcggac tgtgctataa ctaccagatt     5040

agagtgcagt gctgtactcc actgccctgc agcaccagct ccagtcccgc ccagacaacc     5100

cctcctacaa caagtaaaac tacagagact agggcttccg gaagttctgc cccctccagc     5160

acccccggca cagtgtccct gagtaccgcc cgcacaaccc ccgccccagg cacagccacc     5220

agcgtgaaga aaacctttag cacaccttct cccccccccg tgccagccac atccacctcc     5280

agcatgagca ctaccgcccc cggcacctcc gtggtgagtt ccaagcctac tcccacagaa     5340

cccagtacaa gctcttgcct gcaggaactg tgtacatgga ctgagtggat cgacggctcc     5400

taccctgccc ctggaatcaa tggcggagat tttgacacct ttcagaacct gagagacgag     5460

ggctacacat tttgcgagag ccctcgcagc gtgcagtgcc gggccgagtc tttccctaat     5520

acccctctgg ccgacctggg acaggacgtg atctgttccc acactgaagg gctgatctgc     5580

ctgaataaga accagctgcc tccaatctgt tacaactatg agattcgcat ccagtgctgc     5640

gagaccgtga acgtgtgtag ggacattacc cggctgccaa aaacagtggc cacaactcgc     5700

cccacccctc atcctaccgg cgcccagaca cagacaactt tcactacaca tatgccttct     5760

gccagtaccg aacagccaac agccacaagc agagggggcc caaccgccac atctgtgacc     5820

cagggcaccc atactactct ggtgactcgg aactgccacc cccggtgcac ttggactaag     5880

tggtttgacg tggattttcc ctctcctggc cctcatgggg gcgacaaaga aacctataac     5940

aacatcattc gctctggcga gaaaatttgc aggagaccag aagaaattac aagagtgcag     6000

tgtagagcta aaagccaccc agaagtgtcc atcgagcacc tgggccaggt ggtgcagtgt     6060

tctcgggagg agggcctggt gtgcaggaac caggaccagc agggaccatt caagatgtgt     6120

ctgaattatg aggtgagagt gctgtgctgc gagactccta ggggatgcca catgacctct     6180

acccctggct ccacaagttc tagccctgct cagacaaccc ccagcacaac atctaagact     6240

actgagatcc aggcctccgg cagctctgcc ccctccagta ctcccggcac agtgagcctg     6300

tccactgcca ggactacccc cgcccctggc actgccacat ctgtgaagaa gacctttagt     6360

actccttccc cccctcctgt gcctgctacc tccacatcca gtatgtccac taccgctcca     6420

ggaacttccg tggtgtcctc caaaccaact cccactgagc caagcactag cagttgtctg     6480

caggagctgt gtacctggac tgaatggatt gacggaagct accctgcccc tggaattaat     6540

gggggggatt ttgatacctt ccagaatctg agagatgagg gatacacttt ttgtgaaagt     6600

ccacggtccg tgcagtgtag ggccgaaagc tttcctaaca cccctctggg gagactgggc     6660

caggatgtga tctgcagcca tactgagggc ctgatctgcc tgaacaagaa tcagctgccc     6720

ccaatttgct acaattacga gattcggatc cagtgctgcg aaactgtgaa tgtgtgtaga     6780

gatatcacaa ggccacctaa aaccgtggct acaacaaggc ccaccccaca cccaactggc     6840

gcccagaccc agaccacatt cacaacacac atgccctccg ctagtaccga gcagcccacc     6900

gccacctcca ggggaggccc aaccgccact tccgtgacac agggcaccca caccactcca     6960

gtgacaagaa attgccatcc tcgctgcact tggactacat ggtttgatgt ggatttccca     7020

agtcccggac cccatggggg ggacaaagag acttataata atattatcag gagcggcgaa     7080

aagatctgca ggcgcccaga ggagatcaca agactgcagt gtcgggctaa gtcccatcct     7140

gaggtgagca ttgagcacct gggacaggtg gtgcagtgtt ctagggagga aggcctggtg     7200

tgcagaaacc aggaccagca ggggcctttc aaaatgtgcc tgaatatcga agtgagagtg     7260

ctgtgttgtg aaactccaaa aggctgccct gtgactagca cccctgtgac cgctccttcc     7320

acacccagcg ggagagccat tagtccaaca cagtctacaa gctcctggca gaagtctcgc     7380

acaaccactc tggtgaccac ctctacaaca tccacccctc agacaagcac cacctacgct     7440

cacacaacca gcactactag cgcccccaca gctcgcacaa ccagtgcccc tacaaccagc     7500

acaacaagtg tgcccacaac ctccaccatt tccggaccta aaacaacccc aagcccagtg     7560

ccaacaacct ccacaacctc cgctgccact accagcacaa ttagcgcccc aactacaagt     7620

actacaagcg tgcccgggac aaccccatct cctgtgctga ccacttccac caccagtgct     7680

cccacaactc ggaccacctc cgcctccccc gctgggacta catctggccc aggaaataca     7740

cccagccccg tgccaaccac ttctactatc tccgccccca caacatctat tacctctgcc     7800

ccaaccacct ctaccacttc cgctcccaca tcctctacta cttccgggcc cggcaccacc     7860

ccttccccag tgccaactac atccattaca agtgctccaa ccacttctac cactagtgct     7920

cctacaacca gcactacctc cgctccaacc acaagtacaa cctccgcccc cccttaccag     7980

aaccagagca catgtgctgt gtatcatcgg agtctgatta tccagcagca gggctgttct     8040

agcagcgaac ccgtgagact ggcctactgc aggggcaatt gtggcgatag ttcctccatg     8100

tatagtctgg aaggcaatac tgtggagcac cgctgtcagt gctgtcagga gctgagaaca     8160

tctctgagga atgtgactct gcactgtacc gacggcagca gcagagcctt tagctacact     8220

gaagtggagg agtgcgggtg catggggaga agatgccctg cccccggaga cacacagcat     8280

agtgaggaag ccgagcctga acctagccag gaagccgaat ctggcagttg ggagagagga     8340

gtgcctgtgt cccctatgca ttgataatag ggccgcgact ctagatcata atcagccata     8400

ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga     8460

aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca     8520

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt     8580

gtggtttgtc caaactcatc aatgtatctt aaggcgtaaa ttgtaagcgt taatattttg     8640

ttaaaattcg cgttaaattt ttgttaaatc agctcatttt ttaaccaata ggccgaaatc     8700

ggcaaaatcc cttataaatc aaaagaatag accgagatag ggttgagtgt tgttccagtt     8760

tggaacaaga gtccactatt aaagaacgtg gactccaacg tcaaagggcg aaaaaccgtc     8820

tatcagggcg atggcccact acgtgaacca tcaccctaat caagtttttt ggggtcgagg     8880

tgccgtaaag cactaaatcg gaaccctaaa gggagccccc gatttagagc ttgacgggga     8940

aagccggcga acgtggcgag aaaggaaggg aagaaagcga aaggagcggg cgctagggcg     9000

ctggcaagtg tagcggtcac gctgcgcgta accaccacac ccgccgcgct taatgcgccg     9060

ctacagggcg cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta     9120

tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt     9180

caataatatt gaaaaaggaa gagtcctgag gcggaaagaa ccagctgtgg aatgtgtgtc     9240

agttagggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa agcatgcatc     9300

tcaattagtc agcaaccagg tgtggaaagt ccccaggctc cccagcaggc agaagtatgc     9360

aaagcatgca tctcaattag tcagcaacca tagtcccgcc cctaactccg cccatcccgc     9420

ccctaactcc gcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt     9480

atgcagaggc cgaggccgcc tcggcctctg agctattcca gaagtagtga ggaggctttt     9540

ttggaggcct aggcttttgc aaagatcgat caagagacag gatgaggatc gtttcgcatg     9600

attgaacaag atggattgca cgcaggttct ccggccgctt gggtggagag gctattcggc     9660

tatgactggg cacaacagac aatcggctgc tctgatgccg ccgtgttccg gctgtcagcg     9720

caggggcgcc cggttctttt tgtcaagacc gacctgtccg gtgccctgaa tgaactgcaa     9780

gacgaggcag cgcggctatc gtggctggcc acgacgggcg ttccttgcgc agctgtgctc     9840

gacgttgtca ctgaagcggg aagggactgg ctgctattgg gcgaagtgcc ggggcaggat     9900

ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca tcatggctga tgcaatgcgg     9960

cggctgcata cgcttgatcc ggctacctgc ccattcgacc accaagcgaa acatcgcatc    10020

gagcgagcac gtactcggat ggaagccggt cttgtcgatc aggatgatct ggacgaagag    10080

catcaggggc tcgcgccagc cgaactgttc gccaggctca aggcgagcat gcccgacggc    10140

gaggatctcg tcgtgaccca tggcgatgcc tgcttgccga atatcatggt ggaaaatggc    10200

cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg cggaccgcta tcaggacata    10260

gcgttggcta cccgtgatat tgctgaagag cttggcggcg aatgggctga ccgcttcctc    10320

gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg ccttctatcg ccttcttgac    10380

gagttcttct gagcgggact ctggggttcg aaatgaccga ccaagcgacg cccaacctgc    10440

catcacgaga tttcgattcc accgccgcct tctatgaaag gttgggcttc ggaatcgttt    10500

tccgggacgc cggctggatg atcctccagc gcggggatct catgctggag ttcttcgccc    10560

accctagggg gaggctaact gaaacacgga aggagacaat accggaagga acccgcgcta    10620

tgacggcaat aaaaagacag aataaaacgc acggtgttgg gtcgtttgtt cataaacgcg    10680

gggttcggtc ccagggctgg cactctgtcg ataccccacc gagaccccat tggggccaat    10740

acgcccgcgt ttcttccttt tccccacccc accccccaag ttcgggtgaa ggcccagggc    10800

tcgcagccaa cgtcggggcg gcaggccctg ccatagcctc aggttactca tatatacttt    10860

agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata    10920

atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag    10980

aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa    11040

caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt    11100

ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc    11160

cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa    11220

tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa    11280

gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc    11340

ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa    11400

gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa    11460

caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg    11520

ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc    11580

tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg    11640

ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgccatgc    11700

at                                                                   11702


