                         SEQUENCE LISTING

<110>  SANTARIS PHARMA A/S
 
<120>  COMPOUNDS FOR THE MODULATION OF PDZ-BINDING KINASE (PBK) EXPRESSION

<130>  1112WO

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methylcytosine

<400>  1
actttatgtc tccatg                                                       16


<210>  2
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methylcytosine

<400>  2
tacaacattt gaagac                                                       16


<210>  3
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methylcytosine

<400>  3
gactcctaca tcacag                                                       16

<210>  4
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methylcytosine

<400>  4
cagtcacagt catatt                                                       16


<210>  5
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methylcytosine

<400>  5
ctgccttgtc agtaat                                                       16


<210>  6
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methylcytosine

<400>  6
ccaaggagaa tgagac                                                       16


<210>  7
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methylcytosine

<400>  7
tcttctatta agtcat                                                       16


<210>  8
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methylcytosine

<400>  8
tcttgaaatt actgat                                                       16


<210>  9
<211>  13
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA

<220>
<221>  misc_feature
<222>  (3)..(10)
<223>  DNA

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methylcytosine

<400>  9
ttcgataatg atc                                                          13


<210>  10
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methylcytosine

<400>  10
cactagacat ctgttt                                                       16


<210>  11
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methylcytosine

<400>  11
tactgatagt aactat                                                       16


<210>  12
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methylcytosine

<400>  12
caagaaacta tggtcc                                                       16


<210>  13
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methylcytosine

<400>  13
gtacaattcc aagtgc                                                       16


<210>  14
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methylcytosine

<400>  14
agcagtatca aagtac                                                       16


<210>  15
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methylcytosine

<400>  15
tcagtagatc cattaa                                                       16


<210>  16
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methylcytosine

<400>  16
tgataaacac atcagc                                                       16


<210>  17
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methylcytosine

<400>  17
gcttccagtt atcatt                                                       16


<210>  18
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methylcytosine

<400>  18
cagagtctga agtatc                                                       16


<210>  19
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<400>  19
ttaaggtaca aattaa                                                       16


<210>  20
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methylcytosine

<400>  20
aagtgtcctt tattct                                   

<210>  21
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  21
actttatgtc tccatg                                                       16


<210>  22
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  22
tacaacattt gaagac                                                       16


<210>  23
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  23
gactcctaca tcacag                                                       16


<210>  24
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  24
cagtcacagt catatt                                                       16


<210>  25
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  25
ctgccttgtc agtaat                                                       16


<210>  26
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  26
ccaaggagaa tgagac                                                       16


<210>  27
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  27
tcttctatta agtcat                                                       16


<210>  28
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  28
tcttgaaatt actgat                                                       16


<210>  29
<211>  13
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  29
ttcgataatg atc                                                          13


<210>  30
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  30
cactagacat ctgttt                                                       16


<210>  31
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  31
tactgatagt aactat                                                       16


<210>  32
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  32
caagaaacta tggtcc                                                       16


<210>  33
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  33
gtacaattcc aagtgc                                                       16


<210>  34
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  34
agcagtatca aagtac                                                       16


<210>  35
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  35
tcagtagatc cattaa                                                       16


<210>  36
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  36
tgataaacac atcagc                                                       16


<210>  37
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  37
gcttccagtt atcatt                                                       16


<210>  38
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  38
cagagtctga agtatc                                                       16


<210>  39
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  39
ttaaggtaca aattaa                                                       16


<210>  40
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense oligomer

<400>  40
aagtgtcctt tattct              

<210>  41
<211>  1899
<212>  DNA
<213>  Homo Sapiens

<220>
<221>  misc_feature
<222>  (1)..(1899)
<223>  cDNA

<400>  41
agcgcgcgac tttttgaaag ccaggagggt tcgaattgca acggcagctg ccgggcgtat	60
gtgttggtgc tagaggcagc tgcagggtct cgctgggggc cgctcgggac caattttgaa	120
gaggtacttg gccacgactt attttcacct ccgacctttc cttccaggcg gtgagactct	180
ggactgagag tggctttcac aatggaaggg atcagtaatt tcaagacacc aagcaaatta	240
tcagaaaaaa agaaatctgt attatgttca actccaacta taaatatccc ggcctctccg	300
tttatgcaga agcttggctt tggtactggg gtaaatgtgt acctaatgaa aagatctcca	360
agaggtttgt ctcattctcc ttgggctgta aaaaagatta atcctatatg taatgatcat	420
tatcgaagtg tgtatcaaaa gagactaatg gatgaagcta agattttgaa aagccttcat	480
catccaaaca ttgttggtta tcgtgctttt actgaagcca atgatggcag tctgtgtctt	540
gctatggaat atggaggtga aaagtctcta aatgacttaa tagaagaacg atataaagcc	600
agccaagatc cttttccagc agccataatt ttaaaagttg ctttgaatat ggcaagaggg	660
ttaaagtatc tgcaccaaga aaagaaactg cttcatggag acataaagtc ttcaaatgtt	720
gtaattaaag gcgattttga aacaattaaa atctgtgatg taggagtctc tctaccactg	780
gatgaaaata tgactgtgac tgaccctgag gcttgttaca ttggcacaga gccatggaaa	840
cccaaagaag ctgtggagga gaatggtgtt attactgaca aggcagacat atttgccttt	900
ggccttactt tgtgggaaat gatgacttta tcgattccac acattaatct ttcaaatgat	960
gatgatgatg aagataaaac ttttgatgaa agtgattttg atgatgaagc atactatgca	1020
gcgttgggaa ctaggccacc tattaatatg gaagaactgg atgaatcata ccagaaagta	1080
attgaactct tctctgtatg cactaatgaa gaccctaaag atcgtccttc tgctgcacac	1140
attgttgaag ctctggaaac agatgtctag tgatcatctc agctgaagtg tggcttgcgt	1200
aaataactgt ttattccaaa atatttacat agttactatc agtagttatt agactctaaa	1260
attggcatat ttgaggacca tagtttcttg ttaacatatg gataactatt tctaatatga	1320
aatatgctta tattggctat aagcacttgg aattgtactg ggttttctgt aaagttttag	1380
aaactagcta cataagtact ttgatactgc tcatgctgac ttaaaacact agcagtaaaa	1440
cgctgtaaac tgtaacatta aattgaatga ccattacttt tattaatgat ctttcttaaa	1500
tattctatat tttaatggat ctactgacat tagcactttg tacagtacaa aataaagtct	1560
acatttgttt aaaacactga accttttgct gatgtgttta tcaaatgata actggaagct	1620
gaggagaata tgcctcaaaa agagtagctc cttggatact tcagactctg gttacagatt	1680
gtcttgatct cttggatctc ctcagatctt tggtttttgc tttaatttat taaatgtatt	1740
ttccatactg agtttaaaat ttattaattt gtaccttaag catttcccag ctgtgtaaaa	1800
acaataaaac tcaaatagga tgataaagaa taaaggacac tttgggtacc agaaaaaaaa	1860
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa				1899
     