                         SEQUENCE LISTING

<110>  FRANKEL, ARTHUR E.
       SU, YUNPENG
       ST. CROIX, BRAD
 
<120>  ANTIBODIES TO TUMOR ENDOTHELIAL MARKER 8

<130>  SCOT.P0012WO

<140>  UNKNOWN
<141>  2011-11-14

<150>  61/527,339
<151>  2011-08-25

<150>  61/412,999
<151>  2010-11-12

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  1

Asp Ile Val Met Thr Gln Thr Pro Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala 
        


<210>  2
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  2

Gln Val Lys Leu Glu Glu Ser Gly Ala Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Phe Gly Asp Ala Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  3
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  3
cagcttggat acacgccg                                                     18


<210>  4
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  4
tgccaaacct acaggtggg                                                    19


<210>  5
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  5
cggcaggtca tccacgg                                                      17


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  6
cggacagctt gtagtaccca g                                                 21


<210>  7
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  7
tgctaaccct gcccaacg                                                     18


<210>  8
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  8
cctctcaatg gcgaacacg                                                    19


<210>  9
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  9
tgtccctgtc cgagtgctg                                                    19


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  10
ccaggatggc tgagatcacc                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  11
cccatcctgt ctgtccgaac                                                   20


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  12
cacgccattc ttcagccag                                                    19


<210>  13
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  13
gccgaccgaa tgcagaag                                                     18


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  14
ggacattcac agttgtgtgc tag                                               23


<210>  15
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  15
gccaacggta gacgcctc                                                     18


<210>  16
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  16
taggacccac aaggcatcg                                                    19


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  17
cgtagccaga aggagttgcc                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  18
atgtccacac gaagtgaccg                                                   20


<210>  19
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  19
gacattgtga tgacccagac tccaccctct gtacctgtca ctcctggaga gtcagtatcc       60

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg      120

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc      180

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc      240

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaacatct agaatatcca      300

ttcacgttcg gctcggggac aaagttggaa ataaaacggg ct                         342


<210>  20
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  20
caggttaagc tggaggagtc aggggctgag ctggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttctggcta cacattcact gattatgcta tgcactgggt gaagcagagt      120

catgcaaaga gtctagagtg gattggagtt attagtactt actttggtga tgctacctac      180

aaccagaagt tcaagggcaa ggccacaatg actgtagaca aatcctccag cacagcctat      240

atggaacttg ccagactgac atctgaggat tctgccatct attactgtgc aagagaggat      300

tacgtcccgt ttgcttactg gggccaaggg actctggtca ctgtctctgc a               351


<210>  21
<211>  5540
<212>  DNA
<213>  Homo sapiens

<400>  21
aattgcttcc ggggagttgc gagggagcga gggggaataa aggacccgcg aggaagggcc       60

cgcggatggc gcgtccctga gggtcgtggc gagttcgcgg agcgtgggaa ggagcggacc      120

ctgctctccc cgggctgcgg gccatggcca cggcggagcg gagagccctc ggcatcggct      180

tccagtggct ctctttggcc actctggtgc tcatctgcgc cgggcaaggg ggacgcaggg      240

aggatggggg tccagcctgc tacggcggat ttgacctgta cttcattttg gacaaatcag      300

gaagtgtgct gcaccactgg aatgaaatct attactttgt ggaacagttg gctcacaaat      360

tcatcagccc acagttgaga atgtccttta ttgttttctc cacccgagga acaaccttaa      420

tgaaactgac agaagacaga gaacaaatcc gtcaaggcct agaagaactc cagaaagttc      480

tgccaggagg agacacttac atgcatgaag gatttgaaag ggccagtgag cagatttatt      540

atgaaaacag acaagggtac aggacagcca gcgtcatcat tgctttgact gatggagaac      600

tccatgaaga tctctttttc tattcagaga gggaggctaa taggtctcga gatcttggtg      660

caattgttta ctgtgttggt gtgaaagatt tcaatgagac acagctggcc cggattgcgg      720

acagtaagga tcatgtgttt cccgtgaatg acggctttca ggctctgcaa ggcatcatcc      780

actcaatttt gaagaagtcc tgcatcgaaa ttctagcagc tgaaccatcc accatatgtg      840

caggagagtc atttcaagtt gtcgtgagag gaaacggctt ccgacatgcc cgcaacgtgg      900

acagggtcct ctgcagcttc aagatcaatg actcggtcac actcaatgag aagccctttt      960

ctgtggaaga tacttattta ctgtgtccag cgcctatctt aaaagaagtt ggcatgaaag     1020

ctgcactcca ggtcagcatg aacgatggcc tctcttttat ctccagttct gtcatcatca     1080

ccaccacaca ctgttctgac ggttccatcc tggccatcgc cctgctgatc ctgttcctgc     1140

tcctagccct ggctctcctc tggtggttct ggcccctctg ctgcactgtg attatcaagg     1200

aggtccctcc accccctgcc gaggagagtg aggaagaaga tgatgatggt ctgcctaaga     1260

aaaagtggcc aacggtagac gcctcttatt atggtgggag aggcgttgga ggcattaaaa     1320

gaatggaggt tcgttgggga gaaaagggct ccacagaaga aggtgctaag ttggaaaagg     1380

caaagaatgc aagagtcaag atgccggagc aggaatatga attccctgag ccgcgaaatc     1440

tcaacaacaa tatgcgtcgg ccttcttccc cccggaagtg gtactctcca atcaagggaa     1500

aactcgatgc cttgtgggtc ctactgagga aaggatatga tcgtgtgtct gtgatgcgtc     1560

cacagccagg agacacgggg cgctgcatca acttcaccag ggtcaagaac aaccagccag     1620

ccaagtaccc actcaacaac gcctaccaca cctcctcgcc gcctcctgcc cccatctaca     1680

ctcccccacc tcctgcgccc cactgccctc ccccgccccc cagcgcccct acccctccca     1740

tcccgtcccc accttccacc cttccccctc ctccccaggc tccacctccc aacagggcac     1800

ctcctccctc ccgccctcct ccaaggcctt ctgtctagag cccaaagttc ctgctctggg     1860

ctctctcaga aacttcagga gatgttagaa caagtctttc cagttagaga agaggagtgg     1920

tgataaagcc cactgacctt cacacattct aaaaattggt tggcaatgcc agtataccaa     1980

caatcatgat cagctgaaag aaacagatat tttaaattgc cagaaaacaa atgatgaggc     2040

aactacagtc agatttatag ccagccatct atcacctcta gaaggttcca gagacagtga     2100

aactgcaaga tgctctcaac aggattatgt ctcatggaga ccagtaagaa aatcatttat     2160

ctgaaggtga aatgcagagt tggataagaa atacattgct gggtttctaa aatgctgcct     2220

tcctgcctct actccacctc catccctgga ctttggaccc ttggcctagg agcctaagga     2280

ccttcacccc tgtgcaccac ccaagaaaga ggaaaacttt gcctacaact ttggaaatgc     2340

tggggtccct ggtgtggtaa gaaactcaac atcagacggg tatgcagaag gatgttcttc     2400

tgggatttgc aggtacataa aaaatgtatg gcatcttttc cttgcaaatt cttccagttt     2460

ccaagtgaga aggggagcag gtgtttactg atggaaaagg tatgttgcta tgttgatgtg     2520

taagtgaaat cagttgtgtg caatagacag gggcgtattc atgggagcat cagccagttt     2580

ctaaaaccca caggccatca gcagctagag gtggctggct ttggccagac atggacccta     2640

aatcaacaga caatggcatt gtcgaagagc aacctgttaa tgaatcatgt taaaaatcaa     2700

ggtttggctt cagtttaaat cacttgaggt atgaagttta tcctgttttc cagagataaa     2760

cataagttga tcttcccaaa ataccatcat taggacctat cacacaatat cactagtttt     2820

ttttgtttgt ttgttttttg ttttttttct tggtaaagcc atgcaccaca gacttctggg     2880

cagagctgag agacaatggt cctgacataa taaggatctt tgattaaccc ccataaggca     2940

tgtgtgtgta tacaaatata cttctctttg gcttttcgac atagaacctc agctgttaac     3000

caaggggaaa tacatcagat ctgcaacaca gaaatgctct gcctgaaatt tccaccatgc     3060

ctaggactca ccccatttat ccaggtcttt ctggatctgt ttaatcaata agccctataa     3120

tcacttgcta aacactgggc ttcatcaccc agggataaaa acagagatca ttgtcttgga     3180

cctcctgcat cagcctattc aaaattatct ctctctctag ctttccacaa atcctaaaat     3240

tcctgtccca agccacccaa attctcagat cttttctgga acaaggcaga atataaaata     3300

aatatacatt tagtggcttg ggctatggtc tccaaagatc cttcaaaaat acatcaagcc     3360

agcttcattc actcacttta cttagaacag agatataagg gcctgggatg catttatttt     3420

atcaatacca atttttgtgg ccatggcaga cattgctaat caatcacagc actatttcct     3480

attaagccca ctgatttctt cacaatcctt ctcaaattac aattccaaag agccgccact     3540

caacagtcag atgaacccaa cagtcagatg agagaaatga accctacttg ctatctctat     3600

cttagaaagc aaaaacaaac aggagtttcc agggagaatg ggaaagccag ggggcataaa     3660

aggtacagtc aggggaaaat agatctaggc agagtgcctt agtcagggac cacgggcgct     3720

gaatctgcag tgccaacacc aaactgacac atctccaggt gtacctccaa ccctagcctt     3780

ctcccacagc tgcctacaac agagtctccc agccttctca gagagctaaa accagaaatt     3840

tccagactca tgaaagcaac cccccagcct ctccccaacc ctgccgcatt gtctaatttt     3900

tagaacacta ggcttcttct ttcatgtagt tcctcataag caggggccag aatatctcag     3960

ccacctgcag tgacattgct ggacccctga aaaccattcc ataggagaat gggttcccca     4020

ggctcacagt gtagagacat tgagcccatc acaactgttt tgactgctgg cagtctaaaa     4080

cagtccaccc accccatggc actgccgcgt gattcccgcg gccattcaga agttcaagcc     4140

gagatgctga cgttgctgag caacgagatg gtgagcatca gtgcaaatgc accattcagc     4200

acatcagtca tatgcccagt gcagttacaa gatgttgttt cggcaaagca ttttgatgga     4260

atagggaact gcaaatgtat gatgattttg aaaaggctca gcaggatttg ttcttaaacc     4320

gactcagtgt gtcatccccg gttatttaga attacagtta agaaggagaa acttctataa     4380

gactgtatga acaaggtgat atcttcatag tgggctatta caggcaggaa aatgttttaa     4440

ctggtttaca aaatccatca atacttgtgt cattccctgt aaaaggcagg agacatgtga     4500

ttatgatcag gaaactgcac aaaattattg ttttcagccc ccgtgttatt gtccttttga     4560

actgtttttt ttttattaaa gccaaatttg tgttgtatat attcgtattc catgtgttag     4620

atggaagcat ttcctatcca gtgtgaataa aaagaacagt tgtagtaaat tattataaag     4680

ccgatgatat ttcatggcag gttattctac caagctgtgc ttgttggttt ttcccatgac     4740

tgtattgctt ttataaatgt acaaatagtt actgaaatga cgagaccctt gtttgcacag     4800

cattaataag aaccttgata agaaccatat tctgttgaca gccagctcac agtttcttgc     4860

ctgaagcttg gtgcaccctc cagtgagaca caagatctct cttttaccaa agttgagaac     4920

agagctggtg gattaattaa tagtcttcga tatctggcca tgggtaacct cattgtaact     4980

atcatcagaa tgggcagaga tgatcttgaa gtgtcacata cactaaagtc caaacactat     5040

gtcagatggg ggtaaaatcc attaaagaac aggaaaaaat aattataaga tgataagcaa     5100

atgtttcagc ccaatgtcaa cccagttaaa aaaaaaatta atgctgtgta aaatggttga     5160

attagtttgc aaactatata aagacatatg cagtaaaaag tctgttaatg cacatcctgt     5220

gggaatggag tgttctaacc aattgccttt tcttgttatc tgagctctcc tatattatca     5280

tactcagata accaaattaa aagaattaga atatgatttt taatacactt aacattaaac     5340

tcttctaact ttcttctttc tgtgataatt cagaagatag ttatggatct tcaatgcctc     5400

tgagtcattg ttataaaaaa tcagttatca ctataccatg ctataggaga ctgggcaaaa     5460

cctgtacaat gacaaccctg gaagttgctt tttttaaaaa aataataaat ttcttaaatc     5520

aaaaaaaaaa aaaaaaaaaa                                                 5540


<210>  22
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Glu Thr Pro Ala Trp Pro Arg Val Pro Arg Pro Glu Thr Ala Val 
1               5                   10                  15      


Ala Arg Thr Leu Leu Leu Gly Trp Val Phe Ala Gln Val Ala Gly Ala 
            20                  25                  30          


Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
        35                  40                  45              


Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
    50                  55                  60                  


Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
65                  70                  75                  80  


Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val 
                85                  90                  95      


Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
            100                 105                 110         


Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn 
        115                 120                 125             


Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
    130                 135                 140                 


Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
145                 150                 155                 160 


Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg 
                165                 170                 175     


Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
            180                 185                 190         


Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
        195                 200                 205             


Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
    210                 215                 220                 


Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
225                 230                 235                 240 


Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Ile Phe Tyr Ile Ile 
                245                 250                 255     


Gly Ala Val Val Phe Val Val Ile Ile Leu Val Ile Ile Leu Ala Ile 
            260                 265                 270         


Ser Leu His Lys Cys Arg Lys Ala Gly Val Gly Gln Ser Trp Lys Glu 
        275                 280                 285             


Asn Ser Pro Leu Asn Val Ser 
    290                 295 


<210>  23
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Glu Thr Pro Ala Trp Pro Arg Val Pro Arg Pro Glu Thr Ala Val 
1               5                   10                  15      


Ala Arg Thr Leu Leu Leu Gly Trp Val Phe Ala Gln Val Ala Gly Ala 
            20                  25                  30          


Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
        35                  40                  45              


Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
    50                  55                  60                  


Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
65                  70                  75                  80  


Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val 
                85                  90                  95      


Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
            100                 105                 110         


Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn 
        115                 120                 125             


Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
    130                 135                 140                 


Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
145                 150                 155                 160 


Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg 
                165                 170                 175     


Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
            180                 185                 190         


Ser Ser Ser Gly Lys Lys Tyr Ser Thr Ser Leu Glu Leu Trp Tyr Leu 
        195                 200                 205             


Trp Ser Ser Ser Leu Ser Ser Ser Trp Leu Tyr Leu Tyr Thr Ser Val 
    210                 215                 220                 


Glu Arg Gln Glu Trp Gly Arg Ala Gly Arg Arg Thr Pro His 
225                 230                 235             


<210>  24
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is a, c, g, or t

<400>  24
cttccggaat tcsargtnma gctgsagsag tc                                     32


<210>  25
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is a, c, g, or t

<400>  25
cttccggaat tcsargtnma gctgsagsag tcwgg                                  35


<210>  26
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  26
ggaagatctg acatttggga aggactgact ctc                                    33


<210>  27
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  27
ggtgcatgcg gatacagttg gtgcagcatc                                        30


<210>  28
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  28
gggagctcga yattgtgmts acmcarwctm ca                                     32


<210>  29
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  29
aggcgtgtac ggtgggag                                                     18


<210>  30
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  30
cttgtcatcg tcatccttgt aatcgatgtc atgatcttta taatcaccgt catggtcttt       60

gtagtccccg gcgcagatga gc                                                82


<210>  31
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  31
gattacaagg atgacgatga caagcaaggg ggacgcaggg                             40


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  32
ctggtgaagt tgatgcagcg                                                   20


<210>  33
<211>  9201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  33
ctctcagtac aatctgctct gatgccgcat agttaagcca gtatctgctc cctgcttgtg       60

tgttggaggt cgctgagtag tgcgcgagca aaatttaagc tacaacaagg caaggcttga      120

ccgacaattg catgaagaat ctgcttaggg ttaggcgttt tgcgctgctt cgcgatgtac      180

gggccagata tacgcgttga cattgattat tgactagtta ttaatagtaa tcaattacgg      240

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc      300

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca      360

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg      420

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg      480

acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt      540

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca      600

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg      660

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact      720

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag      780

ctctctggct aactagagaa cccactgctt actggcttat cgaaattaat acgactcact      840

atagggagac ccaagctggc tagcgtttaa acttaagctt ggtaccgagc tcggatccac      900

tagtccagtg tggtggaatt ctgcagatat ccaccatgga ttttcaaggg cagattttca      960

gcctcctgct aatcagtatc acagtcatag tgtccagtgg agacattgtg atgacccaga     1020

ctccaccctc tgtacctgtc actcctggag agtcagtatc catctcctgc aggtctagta     1080

agagtctcct gcatagtaat ggcaacactt acttgtattg gttcctgcag aggccaggcc     1140

agtctcctca gctcctgata tatcggatgt ccaaccttgc ctcaggagtc ccagacaggt     1200

tcagtggcag tgggtcagga actgctttca cactgagaat cagtagagtg gaggctgagg     1260

atgtgggtgt ttattactgt atgcaacatc tagaatatcc attcacgttc ggctcgggga     1320

caaagttgga aataaaacgt aagtcgactt ttctcatctt tttttatgtg taagacacag     1380

gttttcatgt taggagttaa agtcagttca gaaaatcttg agaaaatgga gagggctcat     1440

tatcagttga cgtggcatac agtgtcagat tttctgttta tcaagctagt gagattaggg     1500

gcaaaaagag gctttagttg agaggaaagt aattaatact atggtcacca tccaagagat     1560

tggatcggag aataagcatg agtagttatt gagatctggg tctgactgca ggtagcgtgg     1620

tcttctagac gtttaagtgg gagatttgga ggggatgagg aatgaaggaa cttcaggata     1680

gaaaagggct gaagtcaagt tcagctccta aaatggatgt gggagcaaac tttgaagata     1740

aactgaatga cccagaggat gaaacagcgc agatcaaaga ggggcctgga gctctgagaa     1800

gagaaggaga ctcatccgtg ttgagtttcc acaagtactg tcttgagttt tgcaataaaa     1860

gtgggatagc agagttgagt gagccgtagg ctgagttctc tcttttgtct cctaagtttt     1920

tatgactaca aaaatcagtg tatgtcctga aataatcatt aagctgtttg aaagtatgac     1980

tgcttgccat gtagatacca tggcttgctg aataatcaga agaggtgtga ctcttattct     2040

aaaatttgtc acaaaatgtc aaaatgagag actctgtagg aacgagtcct tgacagacag     2100

ctcaaggggt ttttttcctt tgtctcattt ctacatgaaa gtaaatttga aatgatcttt     2160

tttattataa gagtagaaat acagttgggt ttgaactata tgttttaatg gccacggttt     2220

tgtaagacat ttggtccttt gttttcccag ttattactcg attgtaattt tatatcgcca     2280

gcaatggact gaaacggtcc gcaacctctt ctttacaact gggtgacctc gcggctgtgc     2340

cagccatttg gcgttcaccc tgccgctaag ggccatgtga acccccgcgg tagcatccct     2400

tgctccgcgt ggaccacttt cctgaggcac agtgatagga acagagccac taatctgaag     2460

agaacagaga tgtgacagac tacactaatg tgagaaaaac aaggaaaggg tgacttattg     2520

gagatttcag aaataaaatg catttattat tatattccct tattttaatt ttctattagg     2580

gaattagaaa gggcataaac tgctttatcc agtgttatat taaaagcttt ttttttttca     2640

gtgctattta attatttcaa tatcctctca tcaaatgtat ttaaataaca aaagctcaac     2700

caaaaagaaa gaaatatgta attctttcag agtaaaaatc acacccatga cctggccact     2760

gagggcttga tcaattcact ttgaatttgg cattaaatac cattaaggta tattaactga     2820

ttttaaaata agatatattc gtgaccatgt ttttaacttt caaaaatgta gctgccagtg     2880

tgtgatttta tttcagttgt acaaaatatc taaacctata gcaatgtgat taataaaaac     2940

ttaaacatat tttccagtac cttaattctg tgataggaaa attttaatct gagtatttta     3000

atttcataat ctctaaaata gtttaatgat ttgtcattgt gttgctgtcg tttaccccag     3060

ctgatctcaa aagtgatatt taaggagatt attttggtct gcaacaactt gataggacta     3120

ttttagggcc tttttaaagc tctattaaaa ctaacttaca acgattcaaa actgttttaa     3180

actatttcaa aatgatttta gagccttttg aaaactcttt taaacacttt ttaaactcta     3240

ttaaaactaa taagataact tgaaataatt ttcatgtcaa atacattaac tgtttaatgt     3300

ttaaatgcca gatgaaaaat gtaaagctat caagaattca cccagatagg agtatcttca     3360

tagcatgttt ttccctgctt attttccagt gatcacatta ttttgctacc atggttattt     3420

tatacaatta tctgaaaaaa attagttatg aagattaaaa gagaagaaaa tattaaacat     3480

aagagattca gtctttcatg ttgaactgct tggttaacag tgaagttagt tttaaaaaaa     3540

aaaaaaacta tttctgttat cagctgactt ctccctatct gttgacttct cccagcaaaa     3600

gattcttatt ttacatttta actactgctc tcccacccaa cgggtggaat cccccagagg     3660

gggatttcca agaggccacc tggcagttgc tgagggtcag aagtgaagct agccacttcc     3720

tcttaggcag gtggccaaga ttacagttga cctctcctgg tatggctgaa aattgctgca     3780

tatggttaca ggccttgagg cctttgggag ggcttagaga gttgctggaa cagtcagaag     3840

gtggaggggc tgacaccacc caggcgcaga ggcagggctc agggcctgct ctgcagggag     3900

gttttagccc agcccagcca aagtaacccc cgggagcctg ttatcccagc acagtcctgg     3960

aagaggcaca ggggaaataa aagcggacgg aggctttcct tgactcagcc gctgcctggt     4020

cttcttcaga cctgttctga attctaaact ctgagggggt cggatgacgt ggccattctt     4080

tgcctaaagc attgagttta ctgcaaggtc agaaaagcat gcaaagccct cagaatggct     4140

gcaaagagct ccaacaaaac aatttagaac tttattaagg aataggggga agctaggaag     4200

aaactcaaaa catcaagatt ttaaatacgc ttcttggtct ccttgctata attatctggg     4260

ataagcatgc tgttttctgt ctgtccctaa catgccctgt gattatccgc aaacaacaca     4320

cccaagggca gaactttgtt acttaaacac catcctgttt gcttctttcc tcaggaactg     4380

tggctgcacc atctgtcttc atcttcccgc catctgatga gcagttgaaa tctggaactg     4440

cctctgttgt gtgcctgctg aataacttct atcccagaga ggccaaagta cagtggaagg     4500

tggataacgc cctccaatcg ggtaactccc aggagagtgt cacagagcag gacagcaagg     4560

acagcaccta cagcctcagc agcaccctga cgctgagcaa agcagactac gagaaacaca     4620

aagtctacgc ctgcgaagtc acccatcagg gcctgagctc gcccgtcaca aagagcttca     4680

acaggggaga gtgttagagg gagaagtgcc cccacctgct cctcagttcc agcctgaccc     4740

cctcccatcc tttggcctct gacccttttt ccacagggga aaccgctgat cagcctcgac     4800

tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct     4860

ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct     4920

gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg     4980

gcaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag     5040

aaccagctgg ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc     5100

gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc     5160

tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa     5220

tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact     5280

tgattagggt gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt     5340

gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa     5400

ccctatctcg gtctattctt ttgatttata agggattttg ccgatttcgg cctattggtt     5460

aaaaaatgag ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag     5520

ttagggtgtg gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag catgcatctc     5580

aattagtcag caaccaggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa     5640

agcatgcatc tcaattagtc agcaaccata gtcccgcccc taactccgcc catcccgccc     5700

ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat     5760

gcagaggccg aggccgcctc tgcctctgag ctattccaga agtagtgagg aggctttttt     5820

ggaggcctag gcttttgcaa aaagctcccg ggagcttgta tatccatttt cggatctgat     5880

caagagacag gatgaggatc gtttcgcatg attgaacaag atggattgca cgcaggttct     5940

ccggccgctt gggtggagag gctattcggc tatgactggg cacaacagac aatcggctgc     6000

tctgatgccg ccgtgttccg gctgtcagcg caggggcgcc cggttctttt tgtcaagacc     6060

gacctgtccg gtgccctgaa tgaactgcag gacgaggcag cgcggctatc gtggctggcc     6120

acgacgggcg ttccttgcgc agctgtgctc gacgttgtca ctgaagcggg aagggactgg     6180

ctgctattgg gcgaagtgcc ggggcaggat ctcctgtcat ctcaccttgc tcctgccgag     6240

aaagtatcca tcatggctga tgcaatgcgg cggctgcata cgcttgatcc ggctacctgc     6300

ccattcgacc accaagcgaa acatcgcatc gagcgagcac gtactcggat ggaagccggt     6360

cttgtcgatc aggatgatct ggacgaagag catcaggggc tcgcgccagc cgaactgttc     6420

gccaggctca aggcgcgcat gcccgacggc gaggatctcg tcgtgaccca tggcgatgcc     6480

tgcttgccga atatcatggt ggaaaatggc cgcttttctg gattcatcga ctgtggccgg     6540

ctgggtgtgg cggaccgcta tcaggacata gcgttggcta cccgtgatat tgctgaagag     6600

cttggcggcg aatgggctga ccgcttcctc gtgctttacg gtatcgccgc tcccgattcg     6660

cagcgcatcg ccttctatcg ccttcttgac gagttcttct gagcgggact ctggggttcg     6720

aaatgaccga ccaagcgacg cccaacctgc catcacgaga tttcgattcc accgccgcct     6780

tctatgaaag gttgggcttc ggaatcgttt tccgggacgc cggctggatg atcctccagc     6840

gcggggatct catgctggag ttcttcgccc accccaactt gtttattgca gcttataatg     6900

gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt     6960

ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctgtata ccgtcgacct     7020

ctagctagag cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc     7080

tcacaattcc acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat     7140

gagtgagcta actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc     7200

tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg     7260

ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag     7320

cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag     7380

gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc     7440

tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc     7500

agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc     7560

tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt     7620

cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg     7680

ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat     7740

ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag     7800

ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt     7860

ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc     7920

cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta     7980

gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag     8040

atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga     8100

ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa     8160

gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa     8220

tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc     8280

ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga     8340

taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa     8400

gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt     8460

gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg     8520

ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc     8580

aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg     8640

gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag     8700

cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt     8760

actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt     8820

caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac     8880

gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac     8940

ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag     9000

caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa     9060

tactcatact cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga     9120

gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc     9180

cccgaaaagt gccacctgac g                                               9201


<210>  34
<211>  403
<212>  DNA
<213>  Mus musculus

<400>  34
atggattttc aagggcagat tttcagcctc ctgctaatca gtatcacagt catagtgtcc       60

agtggagaca ttgtgatgac ccagactcca ccctctgtac ctgtcactcc tggagagtca      120

gtatccatct cctgcaggtc tagtaagagt ctcctgcata gtaatggcaa cacttacttg      180

tattggttcc tgcagaggcc aggccagtct cctcagctcc tgatatatcg gatgtccaac      240

cttgcctcag gagtcccaga caggttcagt ggcagtgggt caggaactgc tttcacactg      300

agaatcagta gagtggaggc tgaggatgtg ggtgtttatt actgtatgca acatctagaa      360

tatccattca cgttcggctc ggggacaaag ttggaaataa aac                        403


<210>  35
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  35
actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgtta g                                                321


<210>  36
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  36

Asp Ile Val Met Thr Gln Thr Pro Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  37
<211>  568
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  37
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagct                                         568


<210>  38
<211>  9493
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  38
gatctcccga tcccctatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa       60

gccagtatct gctccctgct tgtgtgttgg aggtcgctga gtagtgcgcg agcaaaattt      120

aagctacaac aaggcaaggc ttgaccgaca attgcatgaa gaatctgctt agggttaggc      180

gttttgcgct gcttcgcgat gtacgggcca gatatacgcg ttgacattga ttattgacta      240

gttattaata gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg      300

ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga      360

cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat      420

gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa      480

gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca      540

tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca      600

tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat      660

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg      720

actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac      780

ggtgggaggt ctatataagc agagctctct ggctaactag agaacccact gcttactggc      840

ttatcgaaat taatacgact cactataggg agacccaagc tggctagact cgagcggccg      900

ccactgtgct ggatatccac catgggatgg agctgggtca tcctctttct ggtagcaaca      960

gctacaggtg tgcactccca ggtccagctg cagcagtctg gggctgagct ggtgaggcct     1020

ggggtctcag tgaagatttc ctgcaagggt tctggctaca cattcactga ttatgctatg     1080

cactgggtga agcagagtca tgcaaagagt ctagagtgga ttggagttat tagtacttac     1140

tttggtgatg ctacctacaa ccagaagttc aagggcaagg ccacaatgac tgtagacaaa     1200

tcctccagca cagcctatat ggaacttgcc agactgacat ctgaggattc tgccatctat     1260

tactgtgcaa gagaggatta cgtcccgttt gcttactggg gccaagggac tctggtcact     1320

gtctctgcag ctagcaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc     1380

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg     1440

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta     1500

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc     1560

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa     1620

gttggtgaga ggccagcaca gggagggagg gtgtctgctg gaagccaggc tcagcgctcc     1680

tgcctggacg catcccggct atgcagcccc agtccagggc agcaaggcag gccccgtctg     1740

cctcttcacc cggaggcctc tgcccgcccc actcatgctc agggagaggg tcttctggct     1800

ttttccccag gctctgggca ggcacaggct aggtgcccct aacccaggcc ctgcacacaa     1860

aggggcaggt gctgggctca gacctgccaa gagccatatc cgggaggacc ctgcccctga     1920

cctaagccca ccccaaaggc caaactctcc actccctcag ctcggacacc ttctctcctc     1980

ccagattcca gtaactccca atcttctctc tgcagagccc aaatcttgtg acaaaactca     2040

cacatgccca ccgtgcccag gtaagccagc ccaggcctcg ccctccagct caaggcggga     2100

caggtgccct agagtagcct gcatccaggg acaggcccca gccgggtgct gacacgtcca     2160

cctccatctc ttcctcagca cctgaactcc tggggggacc gtcagtcttc ctcttccccc     2220

caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc gtggtggtgg     2280

acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc gtggaggtgc     2340

ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt gtggtcagcg     2400

tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc aaggtctcca     2460

acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggt gggacccgtg     2520

gggtgcgagg gccacatgga cagaggccgg ctcggcccac cctctgccct gagagtgacc     2580

gctgtaccaa cctctgtccc tacagggcag ccccgagaac cacaggtgta caccctgccc     2640

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     2700

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     2760

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     2820

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     2880

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatgagt gcgacggccg     2940

gcaagccccc gctccccggg ctctcgcggt cgcacgagga tgcttggcac gtaccccctg     3000

tacatacttc ccgggcgccc agcatggaaa taaagcaccc agcgctgccc tgggcccctg     3060

cgagactgtg atggttcttt ccacgggtca ggccgagtct gaggcctgag tggcatgagg     3120

gaggcagagc gggtcccact gtccccacac tggcccaggc tgtgcaggtg tgcctgggcc     3180

gcctagggtg gggctcagcc aggggctgcc ctcggcaggg tgggggattt gccagcgtgg     3240

ccctccctcc agcagcacct gccctgggct gggccacggg aagccctagg agcccctggg     3300

gacagacaca cagcccctgc ctctgtagga gactgtcctg ttctgtgagc gccctgtcct     3360

ccgacctcca tgcccactcg ggggcatgcc tagtccatgt gcgtagggac aggccctccc     3420

tcacccatct acccccacgg cactaacccc tggctgccct gcccagcctc gcacccgcat     3480

ggggacacaa ccgactccgg ggacatgcac tctcgggccc tgtggaggga ctggtgcaga     3540

tgcccacaca cacactcagc ccagacccgt tcaacaaacc ccgcactgag gttggccggc     3600

cacacggcca ccacacacac acgtgcacgc ctcacacacg gagcctcacc cgggcgaact     3660

gcacagcacc cagaccagag caaggtcctc gcacacgtga acactcctcg gacacaggcc     3720

cccacgagcc ccacgcggca cctcaaggcc cacgagcctc tcggcagctt ctccacatgc     3780

tgacctgctc agacaaaccc agccctcctc tcacaagggt gcccctgcag ccgccacaca     3840

cacacagggg atcacacacc acgtcacgtc cctggccctg gcccacttcc cagtgccgcc     3900

cttccctgca gctgcacctc gggggctccc tgcatacgcc ccccgcctcc tgcagccaca     3960

cgcattgccc gagcgaccct ccctggcccc tgtcgctaca tggacccctg gggcttctcc     4020

tcttttctac atggatgcag tttctcctcc tgctgggcac ggtgctgcct gccctggtca     4080

ctctgcgggg gacagggcct ccagggaaag ctgggtcgag gctgggagct ggctcagact     4140

ggccaggcag agccacaggg agggccttcc agaaccaacc atggtccgaa gcgagaggtg     4200

ggtgtcagat ctgtgtgagt cagctcagga ccacagcggg gcggctccca cggcagacat     4260

ggatccacta gagggcccgt ttaaacccgc tgatcagcct cgactgtgcc ttctagttgc     4320

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     4380

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     4440

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     4500

catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag ctggggctct     4560

agggggtatc cccacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg     4620

cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct     4680

tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta     4740

gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt     4800

tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg     4860

ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat     4920

tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt     4980

taacaaaaat ttaacgcgaa ttaattctgt ggaatgtgtg tcagttaggg tgtggaaagt     5040

ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag tcagcaacca     5100

ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg catctcaatt     5160

agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact ccgcccagtt     5220

ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag gccgaggccg     5280

cctctgcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc ctaggctttt     5340

gcaaaaagct cagatcccgg accatgagct tcaataccct gattgactgg aacagctgta     5400

gccctgaaca gcagcgtgcg ctgctgacgc gtccggcgat ttccgcctct gacagtatta     5460

cccggacggt cagcgatatt ctggataatg taaaaacgcg cggtgacgat gccctgcgtg     5520

aatacagcgc taaatttgat aaaacagaag tgacagcgct acgcgtcacc cctgaagaga     5580

tcgccgccgc cggcgcgcgt ctgagcgacg aattaaaaca ggcgatgacc gctgccgtca     5640

aaaatattga aacgttccat tccgcgcaga cgctaccgcc tgtagatgtg gaaacccagc     5700

caggcgtgcg ttgccagcag gttacgcgtc ccgtctcgtc tgtcggtctg tatattcccg     5760

gcggctcggc tccgctcttc tcaacggtgc tgatgctggc gacgccggcg cgcattgcgg     5820

gatgccagaa ggtggttctg tgctcgccgc cgcccatcgc tgatgaaatc ctctatgcgg     5880

cgcaactgtg tggcgtgcag gaaatcttta acgtcggcgg cgcgcaggcg attgccgctc     5940

tggccttcgg cagcgagtcc gtaccgaaag tggataaaat ttttggcccc ggcaacgcct     6000

ttgtaaccga agccaaacgt caggtcagcc agcgtctcga cggcgcggct atcgatatgc     6060

cagccgggcc gtctgaagta ctggtgatcg cagacagcgg cgcaacaccg gatttcgtcg     6120

cttctgacct gctctcccag gctgagcacg gcccggattc ccaggtgatc ctgctgacgc     6180

ctgatgctga cattgcccgc aaggtggcgg aggcggtaga acgtcaactg gcggaactgc     6240

cgcgcgcgga caccgcccgg caggccctga gcgccagtcg tctgattgtg accaaagatt     6300

tagcgcagtg cgtcgccatc tctaatcagt atgggccgga acacttaatc atccagacgc     6360

gcaatgcgcg cgatttggtg gatgcgatta ccagcgcagg ctcggtattt ctcggcgact     6420

ggtcgccgga atccgccggt gattacgctt ccggaaccaa ccatgtttta ccgacctatg     6480

gctatactgc tacctgttcc agccttgggt tagcggattt ccagaaacgg atgaccgttc     6540

aggaactgtc gaaagcgggc ttttccgctc tggcatcaac cattgaaaca ttggcggcgg     6600

cagaacgtct gaccgcccat aaaaatgccg tgaccctgcg cgtaaacgcc ctcaaggagc     6660

aagcatgagc actgaaaaca ctctcagcgt cgctgactta gcccgggatc tttgtgaagg     6720

aaccttactt ctgtggtgtg acataattgg acaaactacc tacagagatt taaagctcta     6780

aggtaaatat aaaattttta agtgtataat gtgttaaact actgattcta attgtttgtg     6840

tattttagat tccaacctat ggaactgatg aatgggagca gtggtggaat gcctttaatg     6900

aggaaaacct gttttgctca gaagaaatgc catctagtga tgatgaggct actgctgact     6960

ctcaacattc tactcctcca aaaaagaaga gaaaggtaga agaccccaag gactttcctt     7020

cagaattgct aagttttttg agtcatgctg tgtttagtaa tagaactctt gcttgctttg     7080

ctatttacac cacaaaggaa aaagctgcac tgctatacaa gaaaattatg gaaaaatatt     7140

ctgtaacctt tataagtagg cataacagtt ataatcataa catactgttt tttcttactc     7200

cacacaggca tagagtgtct gctattaata actatgctca aaaattgtgt acctttagct     7260

ttttaatttg taaaggggtt aataaggaat atttgatgta tagtgccttg actagagatc     7320

ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc     7380

cccctgaacc tgaaacataa aatgaatgca attgttgttg ttctgcatta atgaatcggc     7440

caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc gctcactgac     7500

tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata     7560

cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa     7620

aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct     7680

gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa     7740

agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg     7800

cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca     7860

cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa     7920

ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg     7980

gtaagacacg acttatcgcc actggcagca gccactggta acaggattag cagagcgagg     8040

tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga     8100

acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc     8160

tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag     8220

attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac     8280

gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc     8340

ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag     8400

taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt     8460

ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag     8520

ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca     8580

gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact     8640

ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca     8700

gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg     8760

tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc     8820

atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg     8880

gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca     8940

tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt     9000

atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc     9060

agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc     9120

ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca     9180

tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa     9240

aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat     9300

tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa     9360

aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga cgtcgacgga     9420

tcgggagatc tcccgatccc ctatggtgca ctctcagtac aatctgctct gatgccgcat     9480

agttaagcca gta                                                        9493


<210>  39
<211>  365
<212>  DNA
<213>  Mus musculus

<400>  39
atgggatgga gctgggtcat cctctttctg gtagcaacag ctacaggtgt gcactcccag       60

gtccagctgc agcagtctgg ggctgagctg gtgaggcctg gggtctcagt gaagatttcc      120

tgcaagggtt ctggctacac attcactgat tatgctatgc actgggtgaa gcagagtcat      180

gcaaagagtc tagagtggat tggagttatt agtacttact ttggtgatgc tacctacaac      240

cagaagttca agggcaaggc cacaatgact gtagacaaat cctccagcac agcctatatg      300

gaacttgcca gactgacatc tgaggattct gccatctatt actgtgcaag agaggattac      360

gtccc                                                                  365


<210>  40
<211>  295
<212>  DNA
<213>  Homo sapiens

<400>  40
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttg           295


<210>  41
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  41
cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc       60

tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc      120

ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc aagacaaagc      180

cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc      240

aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc ctcccagccc      300

ccatcgagaa aaccatctcc aaagccaaag                                       330


<210>  42
<211>  323
<212>  DNA
<213>  Homo sapiens

<400>  42
ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga       60

accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc gccgtggagt      120

gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg ctggactccg      180

acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg cagcagggga      240

acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg cagaagagcc      300

tctccctgtc tccgggtaaa tga                                              323


<210>  43
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  43

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Phe Gly Asp Ala Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  44
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  44
agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccag                       45


<210>  45
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  45

Gly Tyr Thr Phe Thr Asp Tyr Ala Met His 
1               5                   10  


<210>  46
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  46

Val Ile Ser Thr Tyr Phe Gly Asp Ala Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  47

Glu Asp Tyr Val Pro Phe Ala Tyr 
1               5               


<210>  48
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  48

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  49

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  50

Met Gln His Leu Glu Tyr Pro Phe Thr 
1               5                   


<210>  51
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  51

Arg Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr 
1               5                   10                  15      


Thr Cys Gln Ala Cys Ser Val Leu 
            20                  


<210>  52
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  52

Ser Thr Leu Phe Ile Glu Arg Val Thr Glu Glu Asp Glu Gly Val Tyr 
1               5                   10                  15      


His Cys Lys Ala Thr Asn Gln Lys 
            20                  


