                         SEQUENCE LISTING

<110>  Dawson, Ted  M.
 
<120>  THE TREATMENT AND PREVENTION OF PATHOLOGICAL CONDITIONS USING 
       IDUNA RELATED TECHNIQUES AND COMPOSITIONS

<130>  39321-0004 PCT

<140>  PCT/US11/60441
<141>  2011-11-11

<150>  61/412,423
<151>  2010-11-11

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1
cctgtgagat gtttgatatt a                                                 21


<210>  2
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2
cctgttctaa tactgcacct t                                                 21


<210>  3
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  3
cauuuuggga guuggggugg gaa                                               23


<210>  4
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  4
accaccgucu ccacccua                                                     18


<210>  5
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C60A Forward

<400>  5
gttttctgtt atctggctgt aaagggtgct t                                      31


<210>  6
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C60A Reverse

<400>  6
aagcaccctt tacagccaga taacagaaaa c                                      31


<210>  7
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H54A Reverse

<400>  7
agtctgccct gtaaggctgt tttctgttat ctg                                    33


<210>  8
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H54A Reverse

<400>  8
cagataacag aaaacagcct tacagggcag act                                    33


<210>  9
<211>  58
<212>  DNA
<213>  Homo sapiens

<400>  9
ccggcctgtg agatgtttga tattactcga gtaatatcaa acatctcaca ggtttttg         58


<210>  10
<211>  58
<212>  DNA
<213>  Homo sapiens and Musca musculus

<400>  10
ccgggcagga agattaagcg agatactcga gtatctcgct taatcttcct gctttttg         58


<210>  11
<211>  58
<212>  DNA
<213>  Homo sapiens

<400>  11
ccggcctgtt ctaatactgc accttctcga gaaggtgcag tattagaaca ggtttttg         58


<210>  12
<211>  58
<212>  DNA
<213>  Homo sapiens and Musca musculus

<400>  12
ccgggccagt agtgatagtg aggatctcga gatcctcact atcactactg gctttttg         58


<210>  13
<211>  58
<212>  DNA
<213>  Homo sapiens, Musca musculus and Rattus norvegicus

<400>  13
ccgggctcat ttacaactca gtggactcga gtccactgag ttgtaaatga gctttttg         58


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Iduna primer: sense

<400>  14
tgggtggtgg cagtatgatg agc                                               23


<210>  15
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Iduna primer: antisense

<400>  15
cttcacctct gtgactccgt tcagc                                             25


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Actin primer: sense

<400>  16
gctcgtcgtc gacaacggct c                                                 21


<210>  17
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Actin primer: antisense

<400>  17
caaacatgat ctgggtcatc ttctc                                             25


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  18
aaagtcgctc tgagttgtta t                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  19
gcgaagagtt tgtcctcaac c                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  20
ggagcgggag aaatggatat g                                                 21


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CreA primer

<400>  21
cccggcaaaa caggtagtta                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CreS primer

<400>  22
catttgggcc agctaaacat                                                   20


<210>  23
<211>  359
<212>  PRT
<213>  Musca musculus

<400>  23

Met Glu Met Ala Gly Cys Gly Glu Ile Asp His Ser Ile Asn Met Leu 
1               5                   10                  15      


Pro Thr Asn Lys Lys Ala Asn Glu Ser Cys Ser Asn Thr Ala Pro Ser 
            20                  25                  30          


Leu Thr Val Pro Glu Cys Ala Ile Cys Leu Gln Thr Cys Val His Pro 
        35                  40                  45              


Val Ser Leu Pro Cys Lys His Val Phe Cys Tyr Leu Cys Val Lys Gly 
    50                  55                  60                  


Ala Ser Trp Leu Gly Lys Arg Cys Ala Leu Cys Arg Gln Glu Ile Pro 
65                  70                  75                  80  


Glu Asp Phe Leu Asp Lys Pro Thr Leu Leu Ser Pro Glu Glu Leu Lys 
                85                  90                  95      


Ala Ala Ser Arg Gly Asn Gly Glu Tyr Ala Trp Tyr Tyr Glu Gly Arg 
            100                 105                 110         


Asn Gly Trp Trp Gln Tyr Asp Glu Arg Thr Ser Arg Glu Leu Glu Asp 
        115                 120                 125             


Ala Phe Ser Lys Gly Lys Lys Asn Thr Glu Met Leu Ile Ala Gly Phe 
    130                 135                 140                 


Leu Tyr Val Ala Asp Leu Glu Asn Met Val Gln Tyr Arg Arg Asn Glu 
145                 150                 155                 160 


His Gly Arg Arg Arg Lys Ile Lys Arg Asp Ile Ile Asp Ile Pro Lys 
                165                 170                 175     


Lys Gly Val Ala Gly Leu Arg Leu Asp Cys Asp Thr Asn Thr Val Asn 
            180                 185                 190         


Leu Ala Arg Glu Ser Ser Ala Asp Gly Ala Asp Ser Gly Ser Ala Gln 
        195                 200                 205             


Thr Gly Ala Ser Val Gln Leu Ala Val Pro Ser Ser Thr Arg Pro Leu 
    210                 215                 220                 


Thr Ser Val Asp Gly Gln Leu Thr Ser Pro Val Thr Pro Ser Pro Asp 
225                 230                 235                 240 


Ala Gly Ile Ser Leu Glu Asp Ser Phe Ala His Leu Gln Leu Ser Gly 
                245                 250                 255     


Asp Ser Ile Ala Glu Arg Ser His Arg Gly Glu Gly Glu Glu Asp His 
            260                 265                 270         


Glu Ser Pro Ser Ser Gly Arg Val Pro Asp Thr Ser Val Glu Glu Thr 
        275                 280                 285             


Glu Ser Asp Ala Ser Ser Asp Ser Glu Asp Ala Pro Val Val Val Ala 
    290                 295                 300                 


Gln His Ser Leu Thr Gln Gln Arg Pro Leu Val Pro Asn Gly Asn Gln 
305                 310                 315                 320 


Thr Val Ala Asp Gln Ser Asp Arg Ser Gly Thr Asp Arg Ser Val Ala 
                325                 330                 335     


Gly Gly Gly Thr Met Ser Val Asn Val Arg Ser Arg Arg Pro Asp Gly 
            340                 345                 350         


Gln Cys Thr Val Ile Glu Val 
        355                 


<210>  24
<211>  352
<212>  PRT
<213>  Rattus norvegicus

<400>  24

Met Ala Gly Cys Gly Glu Ile Asp His Ser Leu Asn Met Leu Pro Thr 
1               5                   10                  15      


Asn Lys Lys Ala Ser Glu Thr Cys Ser Asn Thr Ala Pro Ser Leu Thr 
            20                  25                  30          


Val Pro Glu Cys Ala Ile Cys Leu Gln Thr Cys Val His Pro Val Ser 
        35                  40                  45              


Leu Pro Cys Lys His Val Phe Cys Tyr Leu Cys Val Lys Gly Ala Ser 
    50                  55                  60                  


Trp Leu Gly Lys Arg Cys Ala Leu Cys Arg Gln Glu Ile Pro Glu Asp 
65                  70                  75                  80  


Phe Leu Asp Lys Pro Thr Leu Leu Ser Pro Glu Glu Leu Lys Ala Ala 
                85                  90                  95      


Ser Arg Gly Asn Gly Glu Tyr Val Trp Tyr Tyr Glu Gly Arg Asn Gly 
            100                 105                 110         


Trp Trp Gln Tyr Asp Glu Arg Thr Ser Arg Glu Leu Glu Asp Ala Phe 
        115                 120                 125             


Ser Lys Gly Lys Lys Asn Thr Glu Met Leu Ile Ala Gly Phe Leu Tyr 
    130                 135                 140                 


Val Ala Asp Leu Glu Asn Met Val Gln Tyr Arg Arg Asn Glu His Gly 
145                 150                 155                 160 


Arg Arg Arg Lys Ile Lys Arg Asp Ile Ile Asp Ile Pro Lys Lys Gly 
                165                 170                 175     


Val Ala Gly Leu Arg Leu Asp Cys Asp Ser Asn Thr Val Asn Leu Ala 
            180                 185                 190         


Arg Glu Ser Ser Ala Asp Gly Ala Asp Ser Gly Ser Ala His Thr Gly 
        195                 200                 205             


Ala Ser Val Gln Leu Pro Val Pro Ser Ser Thr Arg Pro Leu Thr Ser 
    210                 215                 220                 


Val Asp Gly Gln Leu Thr Ser Pro Val Thr Pro Ser Pro Asp Ala Gly 
225                 230                 235                 240 


Ala Ser Leu Glu Asp Ser Phe Ala His Leu Gln Leu Ser Gly Asp Ser 
                245                 250                 255     


Ile Ala Glu Arg Ser His Arg Gly Glu Gly Glu Glu Asp His Glu Ser 
            260                 265                 270         


Pro Ser Ser Gly Arg Val Pro Asp Thr Ser Thr Glu Glu Thr Glu Ser 
        275                 280                 285             


Asp Ala Ser Ser Asp Ile Glu Asp Ala Pro Val Val Val Ala Gln His 
    290                 295                 300                 


Ser Leu Thr Gln Gln Arg Leu Leu Val Ser Ser Ala Asn Gln Thr Val 
305                 310                 315                 320 


Ala Glu Arg Ser Asp Arg Ser Val Ala Gly Gly Gly Thr Met Ser Val 
                325                 330                 335     


Asn Val Arg Ser Arg Arg Pro Asp Gly Gln Cys Thr Val Ile Glu Val 
            340                 345                 350         


<210>  25
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Gly Cys Gly Glu Ile Asp His Ser Ile Asn Met Leu Pro Thr 
1               5                   10                  15      


Asn Lys Lys Ala Asn Glu Ser Cys Ser Asn Thr Ala Pro Ser Leu Thr 
            20                  25                  30          


Val Pro Glu Cys Ala Ile Cys Leu Gln Thr Cys Val His Pro Val Ser 
        35                  40                  45              


Leu Pro Cys Lys His Val Phe Cys Tyr Leu Cys Val Lys Gly Ala Ser 
    50                  55                  60                  


Trp Leu Gly Lys Arg Cys Ala Leu Cys Arg Gln Glu Ile Pro Glu Asp 
65                  70                  75                  80  


Phe Leu Asp Lys Pro Thr Leu Leu Ser Pro Glu Glu Leu Lys Ala Ala 
                85                  90                  95      


Ser Arg Glu Asn Gly Glu Tyr Ala Trp Tyr Tyr Glu Gly Arg Asn Gly 
            100                 105                 110         


Trp Trp Gln Tyr Asp Glu Arg Thr Ser Arg Glu Leu Glu Asp Ala Phe 
        115                 120                 125             


Ser Lys Gly Lys Lys Asn Thr Glu Met Leu Ile Ala Gly Phe Leu Tyr 
    130                 135                 140                 


Val Ala Asp Leu Glu Asn Met Val Gln Tyr Arg Arg Asn Glu His Gly 
145                 150                 155                 160 


Arg Arg Arg Lys Val Lys Arg Asp Ile Ile Asp Ile Pro Lys Lys Gly 
                165                 170                 175     


Val Ala Gly Leu Arg Leu Asp Cys Asp Ala Asn Thr Val Asn Leu Ala 
            180                 185                 190         


Arg Glu Ser Ser Ala Asp Gly Ala Asp Ser Val Ser Ala Gln Ser Gly 
        195                 200                 205             


Ala Ser Val Gln Pro Leu Val Ser Ser Val Arg Pro Leu Thr Ser Val 
    210                 215                 220                 


Asp Gly Gln Leu Thr Ser Pro Ala Thr Pro Ser Pro Asp Ala Ser Thr 
225                 230                 235                 240 


Ser Leu Glu Asp Ser Phe Ala His Leu Gln Leu Ser Gly Asp Asn Thr 
                245                 250                 255     


Ala Glu Arg Ser His Arg Gly Glu Gly Glu Glu Asp His Glu Ser Pro 
            260                 265                 270         


Ser Ser Gly Arg Val Pro Ala Pro Asp Thr Ser Ile Glu Glu Thr Glu 
        275                 280                 285             


Ser Asp Ala Ser Ser Asp Ser Glu Asp Val Ser Ala Val Val Ala Gln 
    290                 295                 300                 


His Ser Leu Thr Gln Gln Arg Leu Leu Val Ser Asn Ala Asn Gln Thr 
305                 310                 315                 320 


Val Pro Asp Arg Ser Asp Arg Ser Gly Thr Asp Arg Ser Val Ala Gly 
                325                 330                 335     


Gly Gly Thr Val Ser Val Ser Val Arg Ser Arg Arg Pro Asp Gly Gln 
            340                 345                 350         


Cys Thr Val Ile Glu Val 
        355             


<210>  26
<211>  364
<212>  PRT
<213>  Danio rerio

<400>  26

Met Ala Ser Cys Gly Glu Val Asn Leu Thr Val Asp Ser Leu Thr Ser 
1               5                   10                  15      


Gly Lys Lys Val Ser Gly Glu Ala Val Pro Glu Gly Ser Gly Ser Pro 
            20                  25                  30          


Ser Ser Pro Ser Leu Pro Val Pro Glu Cys Pro Ile Cys Leu Gln Ser 
        35                  40                  45              


Cys Val His Pro Val Arg Leu Pro Cys Arg His Ile Phe Cys Phe Leu 
    50                  55                  60                  


Cys Val Lys Gly Ala Ser Trp His Ser Lys Arg Cys Ala Leu Cys Arg 
65                  70                  75                  80  


Arg Glu Val Pro Glu Asp Phe Leu Glu Arg Pro Thr Leu Leu Ser Pro 
                85                  90                  95      


Glu Glu Leu Lys Ala Ser Ala Thr Gly Gly Cys Gly Thr Gly Ser Ser 
            100                 105                 110         


Gly His Ala Trp Tyr Tyr Glu Gly Arg Asn Gly Trp Trp Gln Tyr Asp 
        115                 120                 125             


Glu Arg Thr Ser Arg Glu Leu Glu Asp Ala Phe Ser Lys Gly Lys Lys 
    130                 135                 140                 


Ser Ala Glu Met Leu Ile Ala Gly Phe Leu Tyr Val Ala Asp Leu Glu 
145                 150                 155                 160 


Asn Met Val Gln Tyr Arg Arg Asn Glu His Gly Arg Arg Arg Arg Met 
                165                 170                 175     


Lys Arg Asp Val Val Asp Ile Pro Lys Lys Gly Val Ala Gly Leu Arg 
            180                 185                 190         


Leu Asp Pro Asp Pro Asn Ser Ser Ala Gly Ala Val Pro Ala Pro Ala 
        195                 200                 205             


Val Val Asp Val Ser Val Asp Gly Ala Ala Ala Glu Arg Glu Ser Ser 
    210                 215                 220                 


Ala Asp Gly Ala Asp Thr Gly Val Ser Gly Gly Arg Pro Gln Gly Thr 
225                 230                 235                 240 


Phe Val Pro Ala Pro Ile Arg Pro Pro Thr Ile Leu Gly Gly His Leu 
                245                 250                 255     


Thr Ser Pro Ala Ser Ser Ser Asp Ile Gln Leu Val Gln Thr Leu Ala 
            260                 265                 270         


Gln Leu Asn Ile Ser Pro Asn Glu Gln Glu Pro Glu Glu Glu Asp Ala 
        275                 280                 285             


Glu Asp Glu Asp Asp Ser Ala Ala Pro Asp Ala Ser Gly Tyr Asp Ser 
    290                 295                 300                 


Glu Ser Gly Thr Ser Asp Asp Asp Glu Gln Val Glu Asp Glu Asp Glu 
305                 310                 315                 320 


Asn Glu His Thr Asp Gly Ser Gln Gly Lys His Arg Leu Gln Gln Leu 
                325                 330                 335     


Asn Arg Pro Pro Pro Gly Gly Gly Pro Ala Asn Ser Gly Asp Arg Ser 
            340                 345                 350         


Gly Cys Pro Asp Gly Gln Cys Thr Val Thr Lys Val 
        355                 360                 


<210>  27
<211>  214
<212>  PRT
<213>  Caenorhabditis elegans


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Pyrrolysine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Pyrrolysine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Pyrrolysine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Pyrrolysine

<400>  27

Met Asn Ala Ser Thr Ser Ser Pro Ser Xaa Xaa Leu Xaa Xaa Ala Ile 
1               5                   10                  15      


Asn Ser Thr Ile Asp Lys Glu Cys Ala Val Cys Tyr Ser Glu Met Ile 
            20                  25                  30          


Leu Pro Thr Thr Ile Pro Ser Cys Gly His Lys Phe Cys Phe Ile Cys 
        35                  40                  45              


Leu Lys Gly Val Ser Val Ser Asn Asn Gly Asp Cys Pro Ile Cys Arg 
    50                  55                  60                  


Gly Pro Ile Asp Ser Gln Ile Phe Lys Lys Pro Leu Gln Ala Val Asp 
65                  70                  75                  80  


Leu Lys Met Asp Ile Pro Gly Thr Pro Ser Ala Ala Ala Pro Asp Pro 
                85                  90                  95      


Val Val Lys Gln Glu Val Asp Asp Glu Asp Val Lys Pro Asp Val Lys 
            100                 105                 110         


Lys Leu Gln Glu Glu Leu Lys Lys Gln Gln Ala Ala Ala Ala Ala Gln 
        115                 120                 125             


Lys Met Phe Trp Leu Tyr Arg Gly Arg His Gln Gly Trp Trp Arg Phe 
    130                 135                 140                 


Asp Pro Arg Ile Glu Lys Glu Ile Glu Glu Ala Phe Thr His Gln Met 
145                 150                 155                 160 


Pro Met Thr Glu Val Thr Ile Cys Gly Asn Pro Tyr Ile Val Asp Phe 
                165                 170                 175     


Ser Gln Met Cys Gln Tyr Pro Lys Asn Gln Ser Asn Tyr Ser Arg Asn 
            180                 185                 190         


Val Lys Tyr Gly Ser Arg Leu Lys Val Leu Lys Ile Leu Ala Lys Ile 
        195                 200                 205             


Asp Arg Lys Ser Ala Phe 
    210                 


