                               SEQUENCE LISTING	

<110> MGH, THE GENERAL HOSPITAL CORPORATION
 
<120> TREATMENT OF ATHEROSCLEROSIS WITH BMP-ALK3 ANTAGONISTS 
      
<130> 030258-069041-PCT

<140>
<141>

<150> 61/413,165
<151> 2010-11-12

<160> 40    

<170> PatentIn version 3.5

<210> 1
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Thr Gly Gly Gly 
1               


<210> 2
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xhis tag

<400> 2
His His His His His His 
1               5       


<210> 3
<211> 225
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Asp or Ala

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Lys or Ala

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Asn or Ala

<400> 3
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
1               5                   10                  15      


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            20                  25                  30          


Arg Thr Pro Glu Val Thr Cys Val Val Val Xaa Val Ser His Glu Asp 
        35                  40                  45              


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    50                  55                  60                  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
65                  70                  75                  80  


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                85                  90                  95      


Tyr Lys Cys Xaa Val Ser Asn Lys Ala Leu Pro Val Pro Ile Glu Lys 
            100                 105                 110         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        115                 120                 125             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    130                 135                 140                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
145                 150                 155                 160 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                165                 170                 175     


Asp Ser Asp Gly Pro Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            180                 185                 190         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        195                 200                 205             


Ala Leu His Xaa His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220                 


Lys 
225 


<210> 4
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Gly Ala Gln Asn Leu Asp Ser Met Leu His Gly Thr Gly Met Lys 
1               5                   10                  15  


<210> 5
<211> 395
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Gly Ala Gln Asn Leu Asp Ser Met Leu His 
            20                  25                  30          


Gly Thr Gly Met Lys Ser Asp Leu Asp Gln Lys Lys Pro Glu Asn Gly 
        35                  40                  45              


Val Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys Tyr Cys 
    50                  55                  60                  


Ser Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile Thr Asn 
65                  70                  75                  80  


Gly His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu Thr Thr 
                85                  90                  95      


Leu Thr Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln Cys Lys 
            100                 105                 110         


Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys Arg Thr 
        115                 120                 125             


Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Val Val Ile 
    130                 135                 140                 


Gly Pro Phe Phe Asp Gly Ser Ile Arg Thr Gly Gly Gly Glu Pro Arg 
145                 150                 155                 160 


Val Pro Ile Thr Gln Asn Pro Cys Pro Pro Leu Lys Glu Cys Pro Pro 
                165                 170                 175     


Cys Ala Ala Pro Asp Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
            180                 185                 190         


Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Met Val Thr 
        195                 200                 205             


Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser 
    210                 215                 220                 


Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His 
225                 230                 235                 240 


Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile 
                245                 250                 255     


Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn 
            260                 265                 270         


Asn Arg Ala Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Arg 
        275                 280                 285             


Gly Pro Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Ala Glu 
    290                 295                 300                 


Glu Met Thr Lys Lys Glu Phe Ser Leu Thr Cys Met Ile Thr Gly Phe 
305                 310                 315                 320 


Leu Pro Ala Glu Ile Ala Val Asp Trp Thr Ser Asn Gly Arg Thr Glu 
                325                 330                 335     


Gln Asn Tyr Lys Asn Thr Ala Thr Val Leu Asp Ser Asp Gly Ser Tyr 
            340                 345                 350         


Phe Met Tyr Ser Lys Leu Arg Val Gln Lys Ser Thr Trp Glu Arg Gly 
        355                 360                 365             


Ser Leu Phe Ala Cys Ser Val Val His Glu Gly Leu His Asn His Leu 
    370                 375                 380                 


Thr Thr Lys Thr Ile Ser Arg Ser Leu Gly Lys 
385                 390                 395 


<210> 6
<211> 360
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Gly Ala Gln Asn Leu Asp Ser Met Leu His Gly Thr Gly Met Lys Ser 
1               5                   10                  15      


Asp Ser Asp Gln Lys Lys Ser Glu Asn Gly Val Thr Leu Ala Pro Glu 
            20                  25                  30          


Asp Thr Leu Pro Phe Leu Lys Cys Tyr Cys Ser Gly His Cys Pro Asp 
        35                  40                  45              


Asp Ala Ile Asn Asn Thr Cys Ile Thr Asn Gly His Cys Phe Ala Ile 
    50                  55                  60                  


Ile Glu Glu Asp Asp Gln Gly Glu Thr Thr Leu Ala Ser Gly Cys Met 
65                  70                  75                  80  


Lys Tyr Glu Gly Ser Asp Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln 
                85                  90                  95      


Leu Arg Arg Thr Ile Glu Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr 
            100                 105                 110         


Leu Gln Pro Thr Leu Pro Pro Val Val Ile Gly Pro Phe Phe Asp Gly 
        115                 120                 125             


Ser Ile Arg Thr Gly Gly Gly Thr His Thr Cys Pro Pro Cys Pro Ala 
    130                 135                 140                 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                165                 170                 175     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            180                 185                 190         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        195                 200                 205             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    210                 215                 220                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
225                 230                 235                 240 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                245                 250                 255     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
            260                 265                 270         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        275                 280                 285             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    290                 295                 300                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                325                 330                 335     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            340                 345                 350         


Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360 


<210> 7
<211> 1131
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt       60

tcgcccggcg cccagaatct ggatagtatg cttcatggca ctgggatgaa atcagactcc      120

gaccagaaaa agtcagaaaa tggagtaacc ttagcaccag aggatacctt gcctttttta      180

aagtgctatt gctcagggca ctgtccagat gatgctatta ataacacatg cataactaat      240

ggacattgct ttgccatcat agaagaagat gaccagggag aaaccacatt agcttcaggg      300

tgtatgaaat atgaaggatc tgattttcag tgcaaagatt ctccaaaagc ccagctacgc      360

cggacaatag aatgttgtcg gaccaattta tgtaaccagt atttgcaacc cacactgccc      420

cctgttgtca taggtccgtt taccggtggt ggaactcaca catgcccacc gtgcccagca      480

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      540

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      600

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      660

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      720

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc      780

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg      840

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc      900

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac      960

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1020

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1080

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatg a              1131


<210> 8
<211> 352
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Gln Asn Leu Asp Ser Met Leu His Gly Thr Gly Met Lys Ser Asp Ser 
1               5                   10                  15      


Asp Gln Lys Lys Ser Glu Asn Gly Val Thr Leu Ala Pro Glu Asp Thr 
            20                  25                  30          


Leu Pro Phe Leu Lys Cys Tyr Cys Ser Gly His Cys Pro Asp Asp Ala 
        35                  40                  45              


Ile Asn Asn Thr Cys Ile Thr Asn Gly His Cys Phe Ala Ile Ile Glu 
    50                  55                  60                  


Glu Asp Asp Gln Gly Glu Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr 
65                  70                  75                  80  


Glu Gly Ser Asp Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg 
                85                  90                  95      


Arg Thr Ile Glu Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln 
            100                 105                 110         


Pro Thr Leu Pro Pro Val Val Ile Gly Pro Phe Thr Gly Gly Gly Thr 
        115                 120                 125             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    130                 135                 140                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
145                 150                 155                 160 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                165                 170                 175     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            180                 185                 190         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        195                 200                 205             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    210                 215                 220                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
225                 230                 235                 240 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                245                 250                 255     


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            260                 265                 270         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        275                 280                 285             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    290                 295                 300                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
305                 310                 315                 320 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                325                 330                 335     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350         


<210> 9
<211> 354
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Gly Ala Gln Asn Leu Asp Ser Met Leu His Gly Thr Gly Met Lys Ser 
1               5                   10                  15      


Asp Ser Asp Gln Lys Lys Ser Glu Asn Gly Val Thr Leu Ala Pro Glu 
            20                  25                  30          


Asp Thr Leu Pro Phe Leu Lys Cys Tyr Cys Ser Gly His Cys Pro Asp 
        35                  40                  45              


Asp Ala Ile Asn Asn Thr Cys Ile Thr Asn Gly His Cys Phe Ala Ile 
    50                  55                  60                  


Ile Glu Glu Asp Asp Gln Gly Glu Thr Thr Leu Ala Ser Gly Cys Met 
65                  70                  75                  80  


Lys Tyr Glu Gly Ser Asp Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln 
                85                  90                  95      


Leu Arg Arg Thr Ile Glu Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr 
            100                 105                 110         


Leu Gln Pro Thr Leu Pro Pro Val Val Ile Gly Pro Phe Thr Gly Gly 
        115                 120                 125             


Gly Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    130                 135                 140                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys 
        


<210> 10
<211> 1113
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt       60

tcgcccggcg cccagaatct ggatagtatg cttcatggca ctgggatgaa atcagactcc      120

gaccagaaaa agtcagaaaa tggagtaacc ttagcaccag aggatacctt gcctttttta      180

aagtgctatt gctcagggca ctgtccagat gatgctatta ataacacatg cataactaat      240

ggacattgct ttgccatcat agaagaagat gaccagggag aaaccacatt agcttcaggg      300

tgtatgaaat atgaaggatc tgattttcag tgcaaagatt ctccaaaagc ccagctacgc      360

cggacaatag aatgttgtcg gaccaattta tgtaaccagt atttgcaacc cacactgccc      420

cctaccggtg gtggaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      480

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      540

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      600

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      660

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      720

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      780

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      840

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      900

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      960

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     1020

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1080

cagaagagcc tctccctgtc tccgggtaaa tga                                  1113


<210> 11
<211> 346
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Gln Asn Leu Asp Ser Met Leu His Gly Thr Gly Met Lys Ser Asp Ser 
1               5                   10                  15      


Asp Gln Lys Lys Ser Glu Asn Gly Val Thr Leu Ala Pro Glu Asp Thr 
            20                  25                  30          


Leu Pro Phe Leu Lys Cys Tyr Cys Ser Gly His Cys Pro Asp Asp Ala 
        35                  40                  45              


Ile Asn Asn Thr Cys Ile Thr Asn Gly His Cys Phe Ala Ile Ile Glu 
    50                  55                  60                  


Glu Asp Asp Gln Gly Glu Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr 
65                  70                  75                  80  


Glu Gly Ser Asp Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg 
                85                  90                  95      


Arg Thr Ile Glu Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln 
            100                 105                 110         


Pro Thr Leu Pro Pro Thr Gly Gly Gly Thr His Thr Cys Pro Pro Cys 
        115                 120                 125             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    130                 135                 140                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
145                 150                 155                 160 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                165                 170                 175     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            180                 185                 190         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        195                 200                 205             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    210                 215                 220                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
225                 230                 235                 240 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
                245                 250                 255     


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            260                 265                 270         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        275                 280                 285             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    290                 295                 300                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
305                 310                 315                 320 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                325                 330                 335     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345     


<210> 12
<211> 348
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Gly Ala Gln Asn Leu Asp Ser Met Leu His Gly Thr Gly Met Lys Ser 
1               5                   10                  15      


Asp Ser Asp Gln Lys Lys Ser Glu Asn Gly Val Thr Leu Ala Pro Glu 
            20                  25                  30          


Asp Thr Leu Pro Phe Leu Lys Cys Tyr Cys Ser Gly His Cys Pro Asp 
        35                  40                  45              


Asp Ala Ile Asn Asn Thr Cys Ile Thr Asn Gly His Cys Phe Ala Ile 
    50                  55                  60                  


Ile Glu Glu Asp Asp Gln Gly Glu Thr Thr Leu Ala Ser Gly Cys Met 
65                  70                  75                  80  


Lys Tyr Glu Gly Ser Asp Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln 
                85                  90                  95      


Leu Arg Arg Thr Ile Glu Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr 
            100                 105                 110         


Leu Gln Pro Thr Leu Pro Pro Thr Gly Gly Gly Thr His Thr Cys Pro 
        115                 120                 125             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    130                 135                 140                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
145                 150                 155                 160 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                165                 170                 175     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            180                 185                 190         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        195                 200                 205             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    210                 215                 220                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
225                 230                 235                 240 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                245                 250                 255     


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            260                 265                 270         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        275                 280                 285             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    290                 295                 300                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
305                 310                 315                 320 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                325                 330                 335     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345             


<210> 13
<211> 1131
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt       60

tcgcccggcg cccttcatgg cactgggatg aaatcagact ccgaccagaa aaagtcagaa      120

aatggagtaa ccttagcacc agaggatacc ttgccttttt taaagtgcta ttgctcaggg      180

cactgtccag atgatgctat taataacaca tgcataacta atggacattg ctttgccatc      240

atagaagaag atgaccaggg agaaaccaca ttagcttcag ggtgtatgaa atatgaagga      300

tctgattttc agtgcaaaga ttctccaaaa gcccagctac gccggacaat agaatgttgt      360

cggaccaatt tatgtaacca gtatttgcaa cccacactgc cccctgttgt cataggtccg      420

ttttttgatg gcagcattcg aaccggtggt ggaactcaca catgcccacc gtgcccagca      480

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      540

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      600

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      660

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      720

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc      780

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg      840

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc      900

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac      960

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1020

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1080

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatg a              1131


<210> 14
<211> 354
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Gly Ala Leu His Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys 
1               5                   10                  15      


Ser Glu Asn Gly Val Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu 
            20                  25                  30          


Lys Cys Tyr Cys Ser Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr 
        35                  40                  45              


Cys Ile Thr Asn Gly His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln 
    50                  55                  60                  


Gly Glu Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp 
65                  70                  75                  80  


Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu 
                85                  90                  95      


Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro 
            100                 105                 110         


Pro Val Val Ile Gly Pro Phe Phe Asp Gly Ser Ile Arg Thr Gly Gly 
        115                 120                 125             


Gly Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    130                 135                 140                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys 
        


<210> 15
<211> 353
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Ala Leu His Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser 
1               5                   10                  15      


Glu Asn Gly Val Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys 
            20                  25                  30          


Cys Tyr Cys Ser Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys 
        35                  40                  45              


Ile Thr Asn Gly His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly 
    50                  55                  60                  


Glu Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe 
65                  70                  75                  80  


Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys 
                85                  90                  95      


Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro 
            100                 105                 110         


Val Val Ile Gly Pro Phe Phe Asp Gly Ser Ile Arg Thr Gly Gly Gly 
        115                 120                 125             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210> 16
<211> 351
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
His Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser Glu Asn 
1               5                   10                  15      


Gly Val Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys Tyr 
            20                  25                  30          


Cys Ser Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile Thr 
        35                  40                  45              


Asn Gly His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu Thr 
    50                  55                  60                  


Thr Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln Cys 
65                  70                  75                  80  


Lys Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys Arg 
                85                  90                  95      


Thr Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Val Val 
            100                 105                 110         


Ile Gly Pro Phe Phe Asp Gly Ser Ile Arg Thr Gly Gly Gly Thr His 
        115                 120                 125             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    130                 135                 140                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
145                 150                 155                 160 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                165                 170                 175     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            180                 185                 190         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        195                 200                 205             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    210                 215                 220                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
225                 230                 235                 240 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                245                 250                 255     


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            260                 265                 270         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        275                 280                 285             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    290                 295                 300                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
305                 310                 315                 320 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                325                 330                 335     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350     


<210> 17
<211> 352
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Leu His Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser Glu 
1               5                   10                  15      


Asn Gly Val Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys 
            20                  25                  30          


Tyr Cys Ser Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile 
        35                  40                  45              


Thr Asn Gly His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu 
    50                  55                  60                  


Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln 
65                  70                  75                  80  


Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys 
                85                  90                  95      


Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Val 
            100                 105                 110         


Val Ile Gly Pro Phe Phe Asp Gly Ser Ile Arg Thr Gly Gly Gly Thr 
        115                 120                 125             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    130                 135                 140                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
145                 150                 155                 160 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                165                 170                 175     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            180                 185                 190         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        195                 200                 205             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    210                 215                 220                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
225                 230                 235                 240 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                245                 250                 255     


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            260                 265                 270         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        275                 280                 285             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    290                 295                 300                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
305                 310                 315                 320 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                325                 330                 335     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350         


<210> 18
<211> 1113
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 18
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt       60

tcgcccggcg cccttcatgg cactgggatg aaatcagact ccgaccagaa aaagtcagaa      120

aatggagtaa ccttagcacc agaggatacc ttgccttttt taaagtgcta ttgctcaggg      180

cactgtccag atgatgctat taataacaca tgcataacta atggacattg ctttgccatc      240

atagaagaag atgaccaggg agaaaccaca ttagcttcag ggtgtatgaa atatgaagga      300

tctgattttc agtgcaaaga ttctccaaaa gcccagctac gccggacaat agaatgttgt      360

cggaccaatt tatgtaacca gtatttgcaa cccacactgc cccctgttgt cataggtccg      420

tttaccggtg gtggaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      480

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      540

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      600

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      660

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      720

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      780

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      840

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      900

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      960

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     1020

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1080

cagaagagcc tctccctgtc tccgggtaaa tga                                  1113


<210> 19
<211> 348
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Gly Ala Leu His Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys 
1               5                   10                  15      


Ser Glu Asn Gly Val Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu 
            20                  25                  30          


Lys Cys Tyr Cys Ser Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr 
        35                  40                  45              


Cys Ile Thr Asn Gly His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln 
    50                  55                  60                  


Gly Glu Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp 
65                  70                  75                  80  


Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu 
                85                  90                  95      


Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro 
            100                 105                 110         


Pro Val Val Ile Gly Pro Phe Thr Gly Gly Gly Thr His Thr Cys Pro 
        115                 120                 125             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    130                 135                 140                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
145                 150                 155                 160 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                165                 170                 175     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            180                 185                 190         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        195                 200                 205             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    210                 215                 220                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
225                 230                 235                 240 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                245                 250                 255     


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            260                 265                 270         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        275                 280                 285             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    290                 295                 300                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
305                 310                 315                 320 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                325                 330                 335     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345             


<210> 20
<211> 347
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Ala Leu His Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser 
1               5                   10                  15      


Glu Asn Gly Val Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys 
            20                  25                  30          


Cys Tyr Cys Ser Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys 
        35                  40                  45              


Ile Thr Asn Gly His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly 
    50                  55                  60                  


Glu Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe 
65                  70                  75                  80  


Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys 
                85                  90                  95      


Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro 
            100                 105                 110         


Val Val Ile Gly Pro Phe Thr Gly Gly Gly Thr His Thr Cys Pro Pro 
        115                 120                 125             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    130                 135                 140                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
145                 150                 155                 160 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                165                 170                 175     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            180                 185                 190         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        195                 200                 205             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    210                 215                 220                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
225                 230                 235                 240 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
                245                 250                 255     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            260                 265                 270         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        275                 280                 285             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    290                 295                 300                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
305                 310                 315                 320 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                325                 330                 335     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345         


<210> 21
<211> 345
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
His Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser Glu Asn 
1               5                   10                  15      


Gly Val Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys Tyr 
            20                  25                  30          


Cys Ser Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile Thr 
        35                  40                  45              


Asn Gly His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu Thr 
    50                  55                  60                  


Thr Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln Cys 
65                  70                  75                  80  


Lys Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys Arg 
                85                  90                  95      


Thr Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Val Val 
            100                 105                 110         


Ile Gly Pro Phe Thr Gly Gly Gly Thr His Thr Cys Pro Pro Cys Pro 
        115                 120                 125             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    130                 135                 140                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
145                 150                 155                 160 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                165                 170                 175     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            180                 185                 190         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        195                 200                 205             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    210                 215                 220                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
225                 230                 235                 240 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
                245                 250                 255     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            260                 265                 270         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        275                 280                 285             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    290                 295                 300                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
305                 310                 315                 320 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                325                 330                 335     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345 


<210> 22
<211> 346
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Leu His Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser Glu 
1               5                   10                  15      


Asn Gly Val Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys 
            20                  25                  30          


Tyr Cys Ser Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile 
        35                  40                  45              


Thr Asn Gly His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu 
    50                  55                  60                  


Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln 
65                  70                  75                  80  


Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys 
                85                  90                  95      


Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Val 
            100                 105                 110         


Val Ile Gly Pro Phe Thr Gly Gly Gly Thr His Thr Cys Pro Pro Cys 
        115                 120                 125             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    130                 135                 140                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
145                 150                 155                 160 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                165                 170                 175     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            180                 185                 190         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        195                 200                 205             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    210                 215                 220                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
225                 230                 235                 240 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
                245                 250                 255     


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            260                 265                 270         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        275                 280                 285             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    290                 295                 300                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
305                 310                 315                 320 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                325                 330                 335     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345     


<210> 23
<211> 1095
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 23
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt       60

tcgcccggcg cccttcatgg cactgggatg aaatcagact ccgaccagaa aaagtcagaa      120

aatggagtaa ccttagcacc agaggatacc ttgccttttt taaagtgcta ttgctcaggg      180

cactgtccag atgatgctat taataacaca tgcataacta atggacattg ctttgccatc      240

atagaagaag atgaccaggg agaaaccaca ttagcttcag ggtgtatgaa atatgaagga      300

tctgattttc agtgcaaaga ttctccaaaa gcccagctac gccggacaat agaatgttgt      360

cggaccaatt tatgtaacca gtatttgcaa cccacactgc cccctaccgg tggtggaact      420

cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc      480

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      540

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag      600

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc      660

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc      720

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc      780

cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa gaaccaggtc      840

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc      900

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc      960

ttcttcctct atagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1020

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1080

tctccgggta aatga                                                      1095


<210> 24
<211> 342
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Gly Ala Leu His Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys 
1               5                   10                  15      


Ser Glu Asn Gly Val Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu 
            20                  25                  30          


Lys Cys Tyr Cys Ser Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr 
        35                  40                  45              


Cys Ile Thr Asn Gly His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln 
    50                  55                  60                  


Gly Glu Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp 
65                  70                  75                  80  


Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu 
                85                  90                  95      


Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro 
            100                 105                 110         


Pro Thr Gly Gly Gly Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        115                 120                 125             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    130                 135                 140                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
145                 150                 155                 160 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                165                 170                 175     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            180                 185                 190         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        195                 200                 205             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    210                 215                 220                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
225                 230                 235                 240 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                245                 250                 255     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            260                 265                 270         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        275                 280                 285             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    290                 295                 300                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
305                 310                 315                 320 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                325                 330                 335     


Ser Leu Ser Pro Gly Lys 
            340         


<210> 25
<211> 341
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Ala Leu His Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser 
1               5                   10                  15      


Glu Asn Gly Val Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys 
            20                  25                  30          


Cys Tyr Cys Ser Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys 
        35                  40                  45              


Ile Thr Asn Gly His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly 
    50                  55                  60                  


Glu Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe 
65                  70                  75                  80  


Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys 
                85                  90                  95      


Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro 
            100                 105                 110         


Thr Gly Gly Gly Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        115                 120                 125             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    130                 135                 140                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
145                 150                 155                 160 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                165                 170                 175     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            180                 185                 190         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        195                 200                 205             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    210                 215                 220                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
225                 230                 235                 240 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                245                 250                 255     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            260                 265                 270         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        275                 280                 285             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    290                 295                 300                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
305                 310                 315                 320 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                325                 330                 335     


Leu Ser Pro Gly Lys 
            340     


<210> 26
<211> 339
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
His Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser Glu Asn 
1               5                   10                  15      


Gly Val Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys Tyr 
            20                  25                  30          


Cys Ser Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile Thr 
        35                  40                  45              


Asn Gly His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu Thr 
    50                  55                  60                  


Thr Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln Cys 
65                  70                  75                  80  


Lys Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys Arg 
                85                  90                  95      


Thr Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Thr Gly 
            100                 105                 110         


Gly Gly Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        115                 120                 125             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    130                 135                 140                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
145                 150                 155                 160 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                165                 170                 175     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            180                 185                 190         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        195                 200                 205             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    210                 215                 220                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
225                 230                 235                 240 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
                245                 250                 255     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            260                 265                 270         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        275                 280                 285             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    290                 295                 300                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
305                 310                 315                 320 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                325                 330                 335     


Pro Gly Lys 
            


<210> 27
<211> 340
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Leu His Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser Glu 
1               5                   10                  15      


Asn Gly Val Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys 
            20                  25                  30          


Tyr Cys Ser Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile 
        35                  40                  45              


Thr Asn Gly His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu 
    50                  55                  60                  


Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln 
65                  70                  75                  80  


Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys 
                85                  90                  95      


Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Thr 
            100                 105                 110         


Gly Gly Gly Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        115                 120                 125             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    130                 135                 140                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
145                 150                 155                 160 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                165                 170                 175     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            180                 185                 190         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        195                 200                 205             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    210                 215                 220                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
225                 230                 235                 240 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                245                 250                 255     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            260                 265                 270         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        275                 280                 285             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    290                 295                 300                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
305                 310                 315                 320 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                325                 330                 335     


Ser Pro Gly Lys 
            340 


<210> 28
<211> 532
<212> PRT
<213> Homo sapiens

<400> 28
Met Pro Gln Leu Tyr Ile Tyr Ile Arg Leu Leu Gly Ala Tyr Leu Phe 
1               5                   10                  15      


Ile Ile Ser Arg Val Gln Gly Gln Asn Leu Asp Ser Met Leu His Gly 
            20                  25                  30          


Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser Glu Asn Gly Val 
        35                  40                  45              


Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys Tyr Cys Ser 
    50                  55                  60                  


Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile Thr Asn Gly 
65                  70                  75                  80  


His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu Thr Thr Leu 
                85                  90                  95      


Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln Cys Lys Asp 
            100                 105                 110         


Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys Arg Thr Asn 
        115                 120                 125             


Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Val Val Ile Gly 
    130                 135                 140                 


Pro Phe Phe Asp Gly Ser Ile Arg Trp Leu Val Leu Leu Ile Ser Met 
145                 150                 155                 160 


Ala Val Cys Ile Ile Ala Met Ile Ile Phe Ser Ser Cys Phe Cys Tyr 
                165                 170                 175     


Lys His Tyr Cys Lys Ser Ile Ser Ser Arg Arg Arg Tyr Asn Arg Asp 
            180                 185                 190         


Leu Glu Gln Asp Glu Ala Phe Ile Pro Val Gly Glu Ser Leu Lys Asp 
        195                 200                 205             


Leu Ile Asp Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu Pro Leu 
    210                 215                 220                 


Leu Val Gln Arg Thr Ile Ala Lys Gln Ile Gln Met Val Arg Gln Val 
225                 230                 235                 240 


Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg Gly Glu 
                245                 250                 255     


Lys Val Ala Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser Trp Phe 
            260                 265                 270         


Arg Glu Thr Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu Asn Ile 
        275                 280                 285             


Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp Thr Gln 
    290                 295                 300                 


Leu Tyr Leu Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr Asp Phe 
305                 310                 315                 320 


Leu Lys Cys Ala Thr Leu Asp Thr Arg Ala Leu Leu Lys Leu Ala Tyr 
                325                 330                 335     


Ser Ala Ala Cys Gly Leu Cys His Leu His Thr Glu Ile Tyr Gly Thr 
            340                 345                 350         


Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile 
        355                 360                 365             


Leu Ile Lys Lys Asn Gly Ser Cys Cys Ile Ala Asp Leu Gly Leu Ala 
    370                 375                 380                 


Val Lys Phe Asn Ser Asp Thr Asn Glu Val Asp Val Pro Leu Asn Thr 
385                 390                 395                 400 


Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Ser 
                405                 410                 415     


Leu Asn Lys Asn His Phe Gln Pro Tyr Ile Met Ala Asp Ile Tyr Ser 
            420                 425                 430         


Phe Gly Leu Ile Ile Trp Glu Met Ala Arg Arg Cys Ile Thr Gly Gly 
        435                 440                 445             


Ile Val Glu Glu Tyr Gln Leu Pro Tyr Tyr Asn Met Val Pro Ser Asp 
    450                 455                 460                 


Pro Ser Tyr Glu Asp Met Arg Glu Val Val Cys Val Lys Arg Leu Arg 
465                 470                 475                 480 


Pro Ile Val Ser Asn Arg Trp Asn Ser Asp Glu Cys Leu Arg Ala Val 
                485                 490                 495     


Leu Lys Leu Met Ser Glu Cys Trp Ala His Asn Pro Ala Ser Arg Leu 
            500                 505                 510         


Thr Ala Leu Arg Ile Lys Lys Thr Leu Ala Lys Met Val Glu Ser Gln 
        515                 520                 525             


Asp Val Lys Ile 
    530         


<210> 29
<211> 1596
<212> DNA
<213> Homo sapiens

<400> 29
atgcctcagc tatacattta catcagatta ttgggagcct atttgttcat catttctcgt       60

gttcaaggac agaatctgga tagtatgctt catggcactg ggatgaaatc agactccgac      120

cagaaaaagt cagaaaatgg agtaacctta gcaccagagg ataccttgcc ttttttaaag      180

tgctattgct cagggcactg tccagatgat gctattaata acacatgcat aactaatgga      240

cattgctttg ccatcataga agaagatgac cagggagaaa ccacattagc ttcagggtgt      300

atgaaatatg aaggatctga ttttcagtgc aaagattctc caaaagccca gctacgccgg      360

acaatagaat gttgtcggac caatttatgt aaccagtatt tgcaacccac actgccccct      420

gttgtcatag gtccgttttt tgatggcagc attcgatggc tggttttgct catttctatg      480

gctgtctgca taattgctat gatcatcttc tccagctgct tttgttacaa acattattgc      540

aagagcatct caagcagacg tcgttacaat cgtgatttgg aacaggatga agcatttatt      600

ccagttggag aatcactaaa agaccttatt gaccagtcac aaagttctgg tagtgggtct      660

ggactacctt tattggttca gcgaactatt gccaaacaga ttcagatggt ccggcaagtt      720

ggtaaaggcc gatatggaga agtatggatg ggcaaatggc gtggcgaaaa agtggcggtg      780

aaagtattct ttaccactga agaagccagc tggtttcgag aaacagaaat ctaccaaact      840

gtgctaatgc gccatgaaaa catacttggt ttcatagcgg cagacattaa aggtacaggt      900

tcctggactc agctctattt gattactgat taccatgaaa atggatctct ctatgacttc      960

ctgaaatgtg ctacactgga caccagagcc ctgcttaaat tggcttattc agctgcctgt     1020

ggtctgtgcc acctgcacac agaaatttat ggcacccaag gaaagcccgc aattgctcat     1080

cgagacctaa agagcaaaaa catcctcatc aagaaaaatg ggagttgctg cattgctgac     1140

ctgggccttg ctgttaaatt caacagtgac acaaatgaag ttgatgtgcc cttgaatacc     1200

agggtgggca ccaaacgcta catggctccc gaagtgctgg acgaaagcct gaacaaaaac     1260

cacttccagc cctacatcat ggctgacatc tacagcttcg gcctaatcat ttgggagatg     1320

gctcgtcgtt gtatcacagg agggatcgtg gaagaatacc aattgccata ttacaacatg     1380

gtaccgagtg atccgtcata cgaagatatg cgtgaggttg tgtgtgtcaa acgtttgcgg     1440

ccaattgtgt ctaatcggtg gaacagtgat gaatgtctac gagcagtttt gaagctaatg     1500

tcagaatgct gggcccacaa tccagcctcc agactcacag cattgagaat taagaagacg     1560

cttgccaaga tggttgaatc ccaagatgta aaaatc                               1596


<210> 30
<211> 129
<212> PRT
<213> Homo sapiens

<400> 30
Gln Asn Leu Asp Ser Met Leu His Gly Thr Gly Met Lys Ser Asp Ser 
1               5                   10                  15      


Asp Gln Lys Lys Ser Glu Asn Gly Val Thr Leu Ala Pro Glu Asp Thr 
            20                  25                  30          


Leu Pro Phe Leu Lys Cys Tyr Cys Ser Gly His Cys Pro Asp Asp Ala 
        35                  40                  45              


Ile Asn Asn Thr Cys Ile Thr Asn Gly His Cys Phe Ala Ile Ile Glu 
    50                  55                  60                  


Glu Asp Asp Gln Gly Glu Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr 
65                  70                  75                  80  


Glu Gly Ser Asp Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg 
                85                  90                  95      


Arg Thr Ile Glu Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln 
            100                 105                 110         


Pro Thr Leu Pro Pro Val Val Ile Gly Pro Phe Phe Asp Gly Ser Ile 
        115                 120                 125             


Arg 
    


<210> 31
<211> 387
<212> DNA
<213> Homo sapiens

<400> 31
cagaatctgg atagtatgct tcatggcact gggatgaaat cagactccga ccagaaaaag       60

tcagaaaatg gagtaacctt agcaccagag gataccttgc cttttttaaa gtgctattgc      120

tcagggcact gtccagatga tgctattaat aacacatgca taactaatgg acattgcttt      180

gccatcatag aagaagatga ccagggagaa accacattag cttcagggtg tatgaaatat      240

gaaggatctg attttcagtg caaagattct ccaaaagccc agctacgccg gacaatagaa      300

tgttgtcgga ccaatttatg taaccagtat ttgcaaccca cactgccccc tgttgtcata      360

ggtccgtttt ttgatggcag cattcga                                          387


<210> 32
<211> 225
<212> PRT
<213> Homo sapiens

<400> 32
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
1               5                   10                  15      


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            20                  25                  30          


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        35                  40                  45              


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    50                  55                  60                  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
65                  70                  75                  80  


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                85                  90                  95      


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            100                 105                 110         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        115                 120                 125             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    130                 135                 140                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
145                 150                 155                 160 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                165                 170                 175     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            180                 185                 190         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        195                 200                 205             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220                 


Lys 
225 


<210> 33
<211> 678
<212> DNA
<213> Homo sapiens

<400> 33
actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc       60

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      120

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      180

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      240

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      300

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag      360

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag      420

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag      480

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc      540

tccttcttcc tctatagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc      600

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc      660

ctgtccccgg gtaaatga                                                    678


<210> 34
<211> 358
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Gln Asn Leu Asp Ser Met Leu His Gly Thr Gly Met Lys Ser Asp Ser 
1               5                   10                  15      


Asp Gln Lys Lys Ser Glu Asn Gly Val Thr Leu Ala Pro Glu Asp Thr 
            20                  25                  30          


Leu Pro Phe Leu Lys Cys Tyr Cys Ser Gly His Cys Pro Asp Asp Ala 
        35                  40                  45              


Ile Asn Asn Thr Cys Ile Thr Asn Gly His Cys Phe Ala Ile Ile Glu 
    50                  55                  60                  


Glu Asp Asp Gln Gly Glu Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr 
65                  70                  75                  80  


Glu Gly Ser Asp Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg 
                85                  90                  95      


Arg Thr Ile Glu Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln 
            100                 105                 110         


Pro Thr Leu Pro Pro Val Val Ile Gly Pro Phe Phe Asp Gly Ser Ile 
        115                 120                 125             


Arg Thr Gly Gly Gly Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    130                 135                 140                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            180                 185                 190         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        195                 200                 205             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    210                 215                 220                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
225                 230                 235                 240 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                245                 250                 255     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
            260                 265                 270         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        275                 280                 285             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    290                 295                 300                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
305                 310                 315                 320 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                325                 330                 335     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            340                 345                 350         


Ser Leu Ser Pro Gly Lys 
        355             


<210> 35
<211> 382
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Gly Ala Gln Asn Leu Asp Ser Met Leu His 
            20                  25                  30          


Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser Glu Asn Gly 
        35                  40                  45              


Val Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys Tyr Cys 
    50                  55                  60                  


Ser Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile Thr Asn 
65                  70                  75                  80  


Gly His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu Thr Thr 
                85                  90                  95      


Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln Cys Lys 
            100                 105                 110         


Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys Arg Thr 
        115                 120                 125             


Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Val Val Ile 
    130                 135                 140                 


Gly Pro Phe Phe Asp Gly Ser Ile Arg Thr Gly Gly Gly Thr His Thr 
145                 150                 155                 160 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                165                 170                 175     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            180                 185                 190         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        195                 200                 205             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    210                 215                 220                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
225                 230                 235                 240 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                245                 250                 255     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            260                 265                 270         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        275                 280                 285             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    290                 295                 300                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
305                 310                 315                 320 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                325                 330                 335     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            340                 345                 350         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        355                 360                 365             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380         


<210> 36
<211> 1146
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 36
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt       60

tcgcccggcg cccagaatct ggatagtatg cttcatggca ctgggatgaa atcagactcc      120

gaccagaaaa agtcagaaaa tggagtaacc ttagcaccag aggatacctt gcctttttta      180

aagtgctatt gctcagggca ctgtccagat gatgctatta ataacacatg cataactaat      240

ggacattgct ttgccatcat agaagaagat gaccagggag aaaccacatt agcttcaggg      300

tgtatgaaat atgaaggatc tgattttcag tgcaaagatt ctccaaaagc ccagctacgc      360

cggacaatag aatgttgtcg gaccaattta tgtaaccagt atttgcaacc cacactgccc      420

cctgttgtca taggtccgtt ttttgatggc agcattcgaa ccggtggggg tactcacaca      480

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca      540

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      600

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      660

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc      720

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac      780

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa      840

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg      900

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg      960

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1020

ctctatagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1080

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtccccg     1140

ggtaaa                                                                1146


<210> 37
<211> 1146
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 37
tttacccggg gacagggaga ggctcttctg cgtgtagtgg ttgtgcagag cctcatgcat       60

cacggagcat gagaagacgt tcccctgctg ccacctgctc ttgtccacgg tgagcttgct      120

atagaggaag aaggagccgt cggagtccag cacgggaggc gtggtcttgt agttgttctc      180

cggctgccca ttgctctccc actccacggc gatgtcgctg ggatagaagc ctttgaccag      240

gcaggtcagg ctgacctggt tcttggtcat ctcctcccgg gatgggggca gggtgtacac      300

ctgtggttct cggggctgcc ctttggcttt ggagatggtt ttctcgatgg gggctgggag      360

ggctttgttg gagaccttgc acttgtactc cttgccattc agccagtcct ggtgcaggac      420

ggtgaggacg ctgaccacac ggtacgtgct gttgtactgc tcctcccgcg gctttgtctt      480

ggcattatgc acctccacgc cgtccacgta ccagttgaac ttgacctcag ggtcttcgtg      540

gctcacgtcc accaccacgc atgtgacctc aggggtccgg gagatcatga gggtgtcctt      600

gggttttggg gggaagagga agactgacgg tccccccagg agttcaggtg ctgggcacgg      660

tgggcatgtg tgagtacccc caccggttcg aatgctgcca tcaaaaaacg gacctatgac      720

aacagggggc agtgtgggtt gcaaatactg gttacataaa ttggtccgac aacattctat      780

tgtccggcgt agctgggctt ttggagaatc tttgcactga aaatcagatc cttcatattt      840

catacaccct gaagctaatg tggtttctcc ctggtcatct tcttctatga tggcaaagca      900

atgtccatta gttatgcatg tgttattaat agcatcatct ggacagtgcc ctgagcaata      960

gcactttaaa aaaggcaagg tatcctctgg tgctaaggtt actccatttt ctgacttttt     1020

ctggtcggag tctgatttca tcccagtgcc atgaagcata ctatccagat tctgggcgcc     1080

gggcgaaacg aagactgctc cacacagcag cagcacacag cagagccctc tcttcattgc     1140

atccat                                                                1146


<210> 38
<211> 395
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Gly Ala Gln Asn Leu Asp Ser Met Leu His 
            20                  25                  30          


Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser Glu Asn Gly 
        35                  40                  45              


Val Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys Tyr Cys 
    50                  55                  60                  


Ser Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile Thr Asn 
65                  70                  75                  80  


Gly His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu Thr Thr 
                85                  90                  95      


Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln Cys Lys 
            100                 105                 110         


Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys Arg Thr 
        115                 120                 125             


Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Val Val Ile 
    130                 135                 140                 


Gly Pro Phe Phe Asp Gly Ser Ile Arg Thr Gly Gly Gly Glu Pro Arg 
145                 150                 155                 160 


Val Pro Ile Thr Gln Asn Pro Cys Pro Pro Leu Lys Glu Cys Pro Pro 
                165                 170                 175     


Cys Ala Ala Pro Asp Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
            180                 185                 190         


Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Met Val Thr 
        195                 200                 205             


Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser 
    210                 215                 220                 


Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His 
225                 230                 235                 240 


Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile 
                245                 250                 255     


Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn 
            260                 265                 270         


Asn Arg Ala Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Arg 
        275                 280                 285             


Gly Pro Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Ala Glu 
    290                 295                 300                 


Glu Met Thr Lys Lys Glu Phe Ser Leu Thr Cys Met Ile Thr Gly Phe 
305                 310                 315                 320 


Leu Pro Ala Glu Ile Ala Val Asp Trp Thr Ser Asn Gly Arg Thr Glu 
                325                 330                 335     


Gln Asn Tyr Lys Asn Thr Ala Thr Val Leu Asp Ser Asp Gly Ser Tyr 
            340                 345                 350         


Phe Met Tyr Ser Lys Leu Arg Val Gln Lys Ser Thr Trp Glu Arg Gly 
        355                 360                 365             


Ser Leu Phe Ala Cys Ser Val Val His Glu Gly Leu His Asn His Leu 
    370                 375                 380                 


Thr Thr Lys Thr Ile Ser Arg Ser Leu Gly Lys 
385                 390                 395 


<210> 39
<211> 1185
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 39
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt       60

tcgcccggcg cccagaatct ggatagtatg cttcatggca ctgggatgaa atcagactcc      120

gaccagaaaa agtcagaaaa tggagtaacc ttagcaccag aggatacctt gcctttttta      180

aagtgctatt gctcagggca ctgtccagat gatgctatta ataacacatg cataactaat      240

ggacattgct ttgccatcat agaagaagat gaccagggag aaaccacatt agcttcaggg      300

tgtatgaaat atgaaggatc tgattttcag tgcaaagatt ctccaaaagc ccagctacgc      360

cggacaatag aatgttgtcg gaccaattta tgtaaccagt atttgcaacc cacactgccc      420

cctgttgtca taggtccgtt ttttgatggc agcattcgaa ccggtggggg tgagcccaga      480

gtgcccataa cacagaaccc ctgtcctcca ctcaaagagt gtcccccatg cgcagctcca      540

gacctcttgg gtggaccatc cgtcttcatc ttccctccaa agatcaagga tgtactcatg      600

atctccctga gccccatggt cacatgtgtg gtggtggatg tgagcgagga tgacccagac      660

gtccagatca gctggtttgt gaacaacgtg gaagtacaca cagctcagac acaaacccat      720

agagaggatt acaacagtac tctccgggtg gtcagtgccc tccccatcca gcaccaggac      780

tggatgagtg gcaaggagtt caaatgcaag gtcaacaaca gagccctccc atcccccatc      840

gagaaaacca tctcaaaacc cagagggcca gtaagagctc cacaggtata tgtcttgcct      900

ccaccagcag aagagatgac taagaaagag ttcagtctga cctgcatgat cacaggcttc      960

ttacctgccg aaattgctgt ggactggacc agcaatgggc gtacagagca aaactacaag     1020

aacaccgcaa cagtcctgga ctctgatggt tcttacttca tgtacagcaa gctcagagta     1080

caaaagagca cttgggaaag aggaagtctt ttcgcctgct cagtggtcca cgagggtctg     1140

cacaatcacc ttacgactaa gaccatctcc cggtctctgg gtaaa                     1185


<210> 40
<211> 1185
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 40
tttacccaga gaccgggaga tggtcttagt cgtaaggtga ttgtgcagac cctcgtggac       60

cactgagcag gcgaaaagac ttcctctttc ccaagtgctc ttttgtactc tgagcttgct      120

gtacatgaag taagaaccat cagagtccag gactgttgcg gtgttcttgt agttttgctc      180

tgtacgccca ttgctggtcc agtccacagc aatttcggca ggtaagaagc ctgtgatcat      240

gcaggtcaga ctgaactctt tcttagtcat ctcttctgct ggtggaggca agacatatac      300

ctgtggagct cttactggcc ctctgggttt tgagatggtt ttctcgatgg gggatgggag      360

ggctctgttg ttgaccttgc atttgaactc cttgccactc atccagtcct ggtgctggat      420

ggggagggca ctgaccaccc ggagagtact gttgtaatcc tctctatggg tttgtgtctg      480

agctgtgtgt acttccacgt tgttcacaaa ccagctgatc tggacgtctg ggtcatcctc      540

gctcacatcc accaccacac atgtgaccat ggggctcagg gagatcatga gtacatcctt      600

gatctttgga gggaagatga agacggatgg tccacccaag aggtctggag ctgcgcatgg      660

gggacactct ttgagtggag gacaggggtt ctgtgttatg ggcactctgg gctcaccccc      720

accggttcga atgctgccat caaaaaacgg acctatgaca acagggggca gtgtgggttg      780

caaatactgg ttacataaat tggtccgaca acattctatt gtccggcgta gctgggcttt      840

tggagaatct ttgcactgaa aatcagatcc ttcatatttc atacaccctg aagctaatgt      900

ggtttctccc tggtcatctt cttctatgat ggcaaagcaa tgtccattag ttatgcatgt      960

gttattaata gcatcatctg gacagtgccc tgagcaatag cactttaaaa aaggcaaggt     1020

atcctctggt gctaaggtta ctccattttc tgactttttc tggtcggagt ctgatttcat     1080

cccagtgcca tgaagcatac tatccagatt ctgggcgccg ggcgaaacga agactgctcc     1140

acacagcagc agcacacagc agagccctct cttcattgca tccat                     1185


