                         SEQUENCE LISTING

<110>  Ho, David
       Huang, Yaoxing
       Pace, Craig
       Song, Ruijiang
       Fang, Qing
 
<120>  FUSION PROTEINS FOR HIV THERAPY

<130>  28203

<140>  Herewith
<141>  2011-11-11

<150>  61/413,178
<151>  2010-11-12

<160>  66    

<170>  PatentIn version 3.5

<210>  1
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  An iMabm36 fusion protein

<400>  1

Met Glu Trp Ser Gly Val Phe Met Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Asp Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr Asp 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys Leu Glu Gly Gly Gly Gly Ser Gly Gly 
465                 470                 475                 480 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gln Val Gln Leu Val Gln Ser 
                485                 490                 495     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
            500                 505                 510         


Ala Ser Ala Phe Asp Phe Ser Asp Tyr Glu Met Ser Trp Val Arg Gln 
        515                 520                 525             


Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn Asp Ser Gly 
    530                 535                 540                 


Asn Thr Ile Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg 
545                 550                 555                 560 


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala 
                565                 570                 575     


Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ile Tyr Gly Gly Asn Ser Gly 
            580                 585                 590         


Gly Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        595                 600                 605     


<210>  2
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MV1 heavy chain

<400>  2

Met Glu Trp Ser Gly Val Phe Met Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Asp Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr Asp 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys Leu Glu 
465                 470             


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  3

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


<210>  4
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m36 variable heavy chain

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Phe Asp Phe Ser Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Asp Ser Gly Asn Thr Ile Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Ile Tyr Gly Gly Asn Ser Gly Gly Glu Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  5
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MV1 light chain

<400>  5

Met Glu Trp Ser Gly Val Phe Ile Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Tyr Ser Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  6
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader sequence

<400>  6

Met Glu Trp Ser Gly Val Phe Ile Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  7
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MV1 variable light chain

<400>  7

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MV1 constant light chain

<400>  8

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  9
<211>  756
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  a PG9-ibalizumab fusion polypeptide

<400>  9

Met Glu Trp Ser Gly Val Phe Met Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Arg Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
            20                  25                  30          


Gly Ser Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser 
        35                  40                  45              


Arg Gln Gly Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Trp Val Ala Phe Ile Lys Tyr Asp Gly Ser Glu Lys Tyr His Ala Asp 
65                  70                  75                  80  


Ser Val Trp Gly Arg Leu Ser Ile Ser Arg Asp Asn Ser Lys Asp Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Phe Cys Val Arg Glu Ala Gly Gly Pro Asp Tyr Arg Asn Gly Tyr Asn 
        115                 120                 125             


Tyr Tyr Asp Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val 
    130                 135                 140                 


Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
                165                 170                 175     


Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser 
            180                 185                 190         


Ile Thr Ile Ser Cys Asn Gly Thr Ser Asn Asp Val Gly Gly Tyr Glu 
        195                 200                 205             


Ser Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Val Val 
    210                 215                 220                 


Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser 
225                 230                 235                 240 


Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln 
                245                 250                 255     


Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Lys Ser Leu Thr Ser Thr Arg 
            260                 265                 270         


Arg Arg Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
    290                 295                 300                 


Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala Ser Val Lys 
305                 310                 315                 320 


Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Ile His 
                325                 330                 335     


Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Asp Trp Ile Gly Tyr Ile 
            340                 345                 350         


Asn Pro Tyr Asn Asp Gly Thr Asp Tyr Asp Glu Lys Phe Lys Gly Lys 
        355                 360                 365             


Ala Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu 
    370                 375                 380                 


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu 
385                 390                 395                 400 


Lys Asp Asn Tyr Ala Thr Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
                405                 410                 415     


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
            420                 425                 430         


Pro Leu Ala Pro Ser Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
        435                 440                 445             


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
    450                 455                 460                 


Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
465                 470                 475                 480 


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
                485                 490                 495     


Ser Ser Leu Gly Thr Gln Thr Tyr Val Cys Asn Val Asn His Lys Pro 
            500                 505                 510         


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ile Lys Thr Cys Gly Gly 
        515                 520                 525             


Gly Ser Lys Pro Pro Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    530                 535                 540                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
545                 550                 555                 560 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                565                 570                 575     


Gln Glu Asp Pro Asp Val Lys Phe Asn Trp Tyr Val Asn Gly Ala Glu 
            580                 585                 590         


Val His His Ala Gln Thr Lys Pro Arg Glu Thr Gln Tyr Asn Ser Thr 
        595                 600                 605             


Tyr Arg Val Val Ser Val Leu Thr Val Thr His Gln Asp Trp Leu Asn 
    610                 615                 620                 


Gly Lys Glu Tyr Thr Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
625                 630                 635                 640 


Ile Gln Lys Thr Ile Ser Lys Asp Lys Gly Gln Pro Arg Glu Pro Gln 
                645                 650                 655     


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Leu Thr Lys Asn Gln Val 
            660                 665                 670         


Ser Leu Thr Cys Pro Val Lys Gly Phe Tyr Pro Ser Asp Ile Val Val 
        675                 680                 685             


Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Thr Tyr Lys Thr Thr Pro 
    690                 695                 700                 


Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Thr 
705                 710                 715                 720 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                725                 730                 735     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Val 
            740                 745                 750         


Ser Pro Gly Lys 
        755     


<210>  10
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  10

Met Glu Trp Ser Gly Val Phe Met Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  11
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG9 variable heavy chain

<400>  11

Gln Arg Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Ser Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Gln Gly 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val Ala 
        35                  40                  45              


Phe Ile Lys Tyr Asp Gly Ser Glu Lys Tyr His Ala Asp Ser Val Trp 
    50                  55                  60                  


Gly Arg Leu Ser Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Thr Tyr Phe Cys Val 
                85                  90                  95      


Arg Glu Ala Gly Gly Pro Asp Tyr Arg Asn Gly Tyr Asn Tyr Tyr Asp 
            100                 105                 110         


Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val Trp Gly Lys 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser 
    130                 135     


<210>  12
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  12

Gly Ile Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  13
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG9 variable light chain

<400>  13

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Asn Gly Thr Ser Asn Asp Val Gly Gly Tyr 
            20                  25                  30          


Glu Ser Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Val 
        35                  40                  45              


Val Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Lys Ser Leu Thr Ser Thr 
                85                  90                  95      


Arg Arg Arg Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  14
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  14

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  15
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ibalizumab variable heavy chain

<400>  15

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr Asp Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  16
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ibalizumab Fc sequence

<400>  16

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Val Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ile Lys Thr Cys Gly Gly Gly Ser Lys Pro Pro Thr Cys 
            100                 105                 110         


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
        115                 120                 125             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    130                 135                 140                 


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Asp Val Lys 
145                 150                 155                 160 


Phe Asn Trp Tyr Val Asn Gly Ala Glu Val His His Ala Gln Thr Lys 
                165                 170                 175     


Pro Arg Glu Thr Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            180                 185                 190         


Thr Val Thr His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Thr Cys Lys 
        195                 200                 205             


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Gln Lys Thr Ile Ser Lys 
    210                 215                 220                 


Asp Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
225                 230                 235                 240 


Arg Glu Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Pro Val Lys 
                245                 250                 255     


Gly Phe Tyr Pro Ser Asp Ile Val Val Glu Trp Glu Ser Ser Gly Gln 
            260                 265                 270         


Pro Glu Asn Thr Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        275                 280                 285             


Ser Tyr Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    290                 295                 300                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
305                 310                 315                 320 


His Tyr Thr Gln Lys Ser Leu Ser Val Ser Pro Gly Lys 
                325                 330             


<210>  17
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ibalizumab light chain

<400>  17

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Tyr Ser Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
225                 230                 235     


<210>  18
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  18

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Gly 
            20  


<210>  19
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ibalizumab variable light chain

<400>  19

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  20
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ibalizumab constant light chain

<400>  20

Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
1               5                   10                  15      


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
            20                  25                  30          


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
        35                  40                  45              


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
65                  70                  75                  80  


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
                85                  90                  95      


Lys Ser Phe Asn Arg Gly Glu 
            100             


<210>  21
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A VRC01-ibalizumab fusion polypeptide

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asp Cys 
            20                  25                  30          


Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg Pro Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Ile Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Thr Ala 
145                 150                 155                 160 


Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser Gly Ser Thr 
            180                 185                 190         


Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg Trp Gly Pro 
        195                 200                 205             


Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp Phe Gly Val 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr Lys Val Gln 
225                 230                 235                 240 


Val Asp Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser 
            260                 265                 270         


Gly Pro Glu Val Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        275                 280                 285             


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Ile His Trp Val Arg Gln 
    290                 295                 300                 


Lys Pro Gly Gln Gly Leu Asp Trp Ile Gly Tyr Ile Asn Pro Tyr Asn 
305                 310                 315                 320 


Asp Gly Thr Asp Tyr Asp Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr 
                325                 330                 335     


Ser Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg 
            340                 345                 350         


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Lys Asp Asn Tyr 
        355                 360                 365             


Ala Thr Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
    370                 375                 380                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
385                 390                 395                 400 


Ser Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
                405                 410                 415     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser 
            420                 425                 430         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        435                 440                 445             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    450                 455                 460                 


Thr Gln Thr Tyr Val Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
465                 470                 475                 480 


Val Asp Lys Arg Val Glu Ile Lys Thr Cys Gly Gly Gly Ser Lys Pro 
                485                 490                 495     


Pro Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
            500                 505                 510         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        515                 520                 525             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
    530                 535                 540                 


Asp Val Lys Phe Asn Trp Tyr Val Asn Gly Ala Glu Val His His Ala 
545                 550                 555                 560 


Gln Thr Lys Pro Arg Glu Thr Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                565                 570                 575     


Ser Val Leu Thr Val Thr His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            580                 585                 590         


Thr Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Gln Lys Thr 
        595                 600                 605             


Ile Ser Lys Asp Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    610                 615                 620                 


Pro Pro Ser Arg Glu Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
625                 630                 635                 640 


Pro Val Lys Gly Phe Tyr Pro Ser Asp Ile Val Val Glu Trp Glu Ser 
                645                 650                 655     


Ser Gly Gln Pro Glu Asn Thr Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            660                 665                 670         


Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        675                 680                 685             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    690                 695                 700                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Val Ser Pro Gly Lys 
705                 710                 715                 720 


<210>  22
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC01 variable heavy chain

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asp Cys 
            20                  25                  30          


Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg Pro Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Ile Val Ser Ser 
        115                 120     


<210>  23
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  23

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  24
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC01 variable light chain

<400>  24

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala 
            20                  25                  30          


Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser 
        35                  40                  45              


Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg 
    50                  55                  60                  


Trp Gly Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp 
65                  70                  75                  80  


Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr 
                85                  90                  95      


Lys Val Gln Val Asp Ile Lys Arg 
            100                 


<210>  25
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rhesus Ibalizumab light chain

<400>  25

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Glu Asp 
        115                 120                 125             


Gln Val Lys Ser Gly Thr Val Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Ser Val Lys Trp Lys Val Asp Gly Val Leu Lys 
145                 150                 155                 160 


Thr Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Asn 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Ser Thr Asp Tyr Gln 
            180                 185                 190         


Ser His Asn Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  26
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rhesus Ibalizumab heavy chain

<400>  26

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr Asp Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Val Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Val Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ile Lys Thr 
    210                 215                 220                 


Cys Gly Gly Gly Ser Lys Pro Pro Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Asp Val Lys Phe Asn Trp Tyr Val Asn 
        275                 280                 285             


Gly Ala Glu Val His His Ala Gln Thr Lys Pro Arg Glu Thr Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Thr His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Thr Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Ser Ile Gln Lys Thr Ile Ser Lys Asp Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Val Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Thr Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Val Ser Pro Gly Lys 
    450                 455 


<210>  27
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rhesus PG9 scFv

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Gln 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Lys Tyr Asp Gly Ser Glu Lys Tyr His Ala Asp Ser Val 
    50                  55                  60                  


Trp Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Gly Pro Asp Tyr Arg Asn Gly Tyr Asn Tyr Tyr 
            100                 105                 110         


Asp Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val Trp Gly 
        115                 120                 125             


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala 
145                 150                 155                 160 


Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr 
                165                 170                 175     


Ile Ser Cys Asn Gly Thr Ser Asn Asp Val Gly Gly Tyr Glu Ser Val 
            180                 185                 190         


Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Val Ile Tyr 
        195                 200                 205             


Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser 
    210                 215                 220                 


Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu 
225                 230                 235                 240 


Asp Glu Ala Asp Tyr Tyr Cys Lys Ser Leu Thr Ser Thr Arg Arg Arg 
                245                 250                 255     


Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            260                 265         


<210>  28
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of Rhesus PG9 scFv

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Gln 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Lys Tyr Asp Gly Ser Glu Lys Tyr His Ala Asp Ser Val 
    50                  55                  60                  


Trp Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Gly Pro Asp Tyr Arg Asn Gly Tyr Asn Tyr Tyr 
            100                 105                 110         


Asp Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val Trp Gly 
        115                 120                 125             


Lys Gly Thr Thr Val Thr Val Ser Ser 
    130                 135         


<210>  29
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of Rhesus PG9 scFv

<400>  29

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Asn Gly Thr Ser Asn Asp Val Gly Gly Tyr 
            20                  25                  30          


Glu Ser Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Val Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Lys Ser Leu Thr Ser Thr 
                85                  90                  95      


Arg Arg Arg Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110


<210>  30
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iMab-m36 heavy chain containing the LALA+FcRn mutations

<400>  30

Met Glu Trp Ser Gly Val Phe Met Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Asp Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr Asp 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys Leu Glu Gly Gly Gly Gly Ser Gly Gly 
465                 470                 475                 480 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gln Val Gln Leu Val Gln Ser 
                485                 490                 495     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
            500                 505                 510         


Ala Ser Ala Phe Asp Phe Ser Asp Tyr Glu Met Ser Trp Val Arg Gln 
        515                 520                 525             


Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn Asp Ser Gly 
    530                 535                 540                 


Asn Thr Ile Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg 
545                 550                 555                 560 


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala 
                565                 570                 575     


Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ile Tyr Gly Gly Asn Ser Gly 
            580                 585                 590         


Gly Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        595                 600                 605     


<210>  31
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iMab heavy chain with LALA and FcRn mutations

<400>  31

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr Asp Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  32
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  32

Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly 


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  33

Gly Gly Gly Gly Ser 
1               5   


<210>  34
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 
        195                 200                 205             


Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 
    210                 215                 220                 


Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu 
                245                 250                 255     


Lys Asn Lys Glu Val Ser Val Lys Trp Val Thr Gln Asp Pro Lys Leu 
            260                 265                 270         


Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu 
        275                 280                 285             


Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys 
    290                 295                 300                 


Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr 
305                 310                 315                 320 


Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro 
                325                 330                 335     


Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 
            340                 345                 350         


Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
    370                 375                 380                 


Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile 
385                 390                 395                 400 


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
                405                 410                 415     


Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met 
            420                 425                 430         


Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro 
        435                 440                 445             


His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
    450                 455             


<210>  35
<211>  854
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Arg Val Lys Glu Lys Tyr Gln His Leu Trp Arg Trp Gly Trp Lys 
1               5                   10                  15      


Trp Gly Thr Met Leu Leu Gly Ile Leu Met Ile Cys Ser Ala Thr Glu 
            20                  25                  30          


Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
        35                  40                  45              


Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu 
    50                  55                  60                  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
65                  70                  75                  80  


Pro Gln Glu Val Val Leu Val Asn Val Thr Glu Asn Phe Asn Met Trp 
                85                  90                  95      


Lys Asp Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
            100                 105                 110         


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Ser 
        115                 120                 125             


Leu Lys Cys Thr Asp Leu Lys Asn Asp Thr Asn Thr Asn Ser Ser Ser 
    130                 135                 140                 


Gly Arg Met Ile Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn 
145                 150                 155                 160 


Ile Ser Thr Ser Ile Arg Asp Lys Val Gln Lys Glu Tyr Ala Phe Phe 
                165                 170                 175     


Tyr Lys Leu Asp Ile Val Pro Ile Asp Asn Thr Ser Tyr Arg Leu Ile 
            180                 185                 190         


Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe 
        195                 200                 205             


Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Asp Val Val Ile Arg Ser 
            260                 265                 270         


Ala Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Thr 
        275                 280                 285             


Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser 
    290                 295                 300                 


Ile Arg Ile Gln Arg Gly Pro Gly Arg Ala Phe Val Thr Ile Gly Lys 
305                 310                 315                 320 


Ile Gly Asn Met Arg Gln Ala His Cys Asn Ile Ser Arg Ala Lys Trp 
                325                 330                 335     


Asn Ala Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
            340                 345                 350         


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
        355                 360                 365             


Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
    370                 375                 380                 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser Thr 
385                 390                 395                 400 


Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp Thr Ile Thr Leu Pro Cys 
                405                 410                 415     


Arg Ile Lys Gln Phe Ile Asn Met Trp Gln Glu Val Gly Lys Ala Met 
            420                 425                 430         


Tyr Ala Pro Pro Ile Ser Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr 
        435                 440                 445             


Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn Asn Asn Gly Ser Glu 
    450                 455                 460                 


Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu 
465                 470                 475                 480 


Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro 
                485                 490                 495     


Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala Val Gly 
            500                 505                 510         


Ile Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met 
        515                 520                 525             


Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser 
    530                 535                 540                 


Asp Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln 
545                 550                 555                 560 


Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 
                565                 570                 575     


Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly 
            580                 585                 590         


Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp 
        595                 600                 605             


Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn Asn Met 
    610                 615                 620                 


Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile 
625                 630                 635                 640 


His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln 
                645                 650                 655     


Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asn 
            660                 665                 670         


Ile Thr Asn Trp Leu Trp Tyr Ile Lys Leu Phe Ile Met Ile Val Gly 
        675                 680                 685             


Gly Leu Val Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Val Asn 
    690                 695                 700                 


Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Leu Pro 
705                 710                 715                 720 


Ile Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu Gly Gly 
                725                 730                 735     


Glu Arg Gly Arg Asp Arg Ser Ile Arg Leu Val Asn Gly Ser Leu Ala 
            740                 745                 750         


Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg 
        755                 760                 765             


Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu Leu Gly 
    770                 775                 780                 


Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu Gln Tyr 
785                 790                 795                 800 


Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Asn Leu Leu Asn Ala Thr 
                805                 810                 815     


Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu Val Leu Gln 
            820                 825                 830         


Ala Ala Tyr Arg Ala Ile Arg His Ile Pro Arg Arg Ile Arg Gln Gly 
        835                 840                 845             


Leu Glu Arg Ile Leu Leu 
    850                 


<210>  36
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  36

Thr Ser Tyr Val Ile His 
1               5       


<210>  37
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  37

Thr Ser Gln Thr Ile His 
1               5       


<210>  38
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  38

Thr Ser Gln Thr Leu His 
1               5       


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  39

Thr Ala Gln Thr Ile His 
1               5       


<210>  40
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  40

Thr Ala Gln Thr Leu His 
1               5       


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  41

Thr Glu Gln Thr Leu His 
1               5       


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  42

Thr Asp Gln Thr Leu His 
1               5       


<210>  43
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  43

Thr Asp Gln Thr Met His 
1               5       


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  44

Thr Gly Gln Thr Leu His 
1               5       


<210>  45
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  45

Thr Asn Gln Thr Leu His 
1               5       


<210>  46
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  46

Thr Asn Gln Val Ile His 
1               5       


<210>  47
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  47

Thr Asp Tyr Thr Phe His 
1               5       


<210>  48
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  48

Thr Glu Tyr Thr Phe His 
1               5       


<210>  49
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  49

Thr Asp Tyr Thr Ile His 
1               5       


<210>  50
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  50

Glu Gln Thr Leu His 
1               5   


<210>  51
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  51

Ala Gln Thr Leu His 
1               5   


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  52

Glu Tyr Thr Phe His 
1               5   


<210>  53
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  53

Ser Gln Thr Leu His 
1               5   


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  54

Asp Tyr Thr Phe His 
1               5   


<210>  55
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  55

Asp Gln Thr Leu His 
1               5   


<210>  56
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  56

Ser Gln Thr Ile His 
1               5   


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  57

Asp Tyr Thr Ile His 
1               5   


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence of CDR-H1 of iMab

<400>  58

Ser Tyr Val Ile His 
1               5   


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  59

Ser Arg Val Leu Ser 
1               5   


<210>  60
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence of CDR-H3 of iMab

<400>  60

Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp Phe Ala 
1               5                   10                  


<210>  61
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AREKDNYATGAWFA

<400>  61

Ala Arg Glu Lys Asp Asn Tyr Ala Val Pro Gly Trp Phe Ala 
1               5                   10                  


<210>  62
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  62

Ala Arg Glu Lys Asp Ser Leu Thr Thr Gly Ala Trp Phe Ala 
1               5                   10                  


<210>  63
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  63

Val Arg Glu Lys Asp Ser Phe Ala Thr Gly Ala Trp Phe Ala 
1               5                   10                  


<210>  64
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  64

Ala Arg Gln Ala Ala Asn Tyr Ala Thr Gly Ala Trp Phe Ala 
1               5                   10                  


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  65

Glu Tyr Thr Ile His 
1               5   


<210>  66
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence from affinity maturation variant

<400>  66

Ala Arg Ala Lys Asp Asn Tyr Ala Thr Gly Ala Trp Phe Ala 
1               5                   10              


