                         SEQUENCE LISTING

<110>  Fred Hutchinson Cancer Research Center
       Miller, Arthur D.
       Halbert, Christine L.
       Metzger, Michael J.
 
<120>  COMPOSITIONS AND METHODS FOR GENERATING RECOMBINANT 
       ADENO-ASSOCIATED VIRAL VECTORS

<130>  FHCR-1-38154

<150>  US 61/412,237
<151>  2010-11-10

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  2211
<212>  DNA
<213>  Adeno-associated virus 6


<220>
<221>  CDS
<222>  (1)..(2211)

<400>  1
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctc tct         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gag ggc att cgc gag tgg tgg gac ttg aaa cct gga gcc ccg aaa ccc         96
Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro           
            20                  25                  30                    

aaa gcc aac cag caa aag cag gac gac ggc cgg ggt ctg gtg ctt cct        144
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggc tac aag tac ctc gga ccc ttc aac gga ctc gac aag ggg gag ccc        192
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gcg gcg gat gca gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctc aaa gcg ggt gac aat ccg tac ctg cgg tat aac cac gcc        288
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttt cag gag cgt ctg caa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aag aag agg gtt ctc gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro           
        115                 120                 125                       

ttt ggt ctg gtt gag gaa ggt gct aag acg gct cct gga aag aaa cgt        432
Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

ccg gta gag cag tcg cca caa gag cca gac tcc tcc tcg ggc att ggc        480
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly           
145                 150                 155                 160           

aag aca ggc cag cag ccc gct aaa aag aga ctc aat ttt ggt cag act        528
Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr           
                165                 170                 175               

ggc gac tca gag tca gtc ccc gac cca caa cct ctc gga gaa cct cca        576
Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro           
            180                 185                 190                   

gca acc ccc gct gct gtg gga cct act aca atg gct tca ggc ggt ggc        624
Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly           
        195                 200                 205                       

gca cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt aat gcc        672
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala           
    210                 215                 220                           

tca gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac aga gtc atc        720
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile           
225                 230                 235                 240           

acc acc agc acc cga aca tgg gcc ttg ccc acc tat aac aac cac ctc        768
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu           
                245                 250                 255               

tac aag caa atc tcc agt gct tca acg ggg gcc agc aac gac aac cac        816
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His           
            260                 265                 270                   

tac ttc ggc tac agc acc ccc tgg ggg tat ttt gat ttc aac aga ttc        864
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe           
        275                 280                 285                       

cac tgc cat ttc tca cca cgt gac tgg cag cga ctc atc aac aac aat        912
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn           
    290                 295                 300                           

tgg gga ttc cgg ccc aag aga ctc aac ttc aag ctc ttc aac atc caa        960
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln           
305                 310                 315                 320           

gtc aag gag gtc acg acg aat gat ggc gtc acg acc atc gct aat aac       1008
Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn           
                325                 330                 335               

ctt acc agc acg gtt caa gtc ttc tcg gac tcg gag tac cag ttg ccg       1056
Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro           
            340                 345                 350                   

tac gtc ctc ggc tct gcg cac cag ggc tgc ctc cct ccg ttc ccg gcg       1104
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala           
        355                 360                 365                       

gac gtg ttc atg att ccg cag tac ggc tac cta acg ctc aac aat ggc       1152
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly           
    370                 375                 380                           

agc cag gca gtg gga cgg tca tcc ttt tac tgc ctg gaa tat ttc cca       1200
Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro           
385                 390                 395                 400           

tcg cag atg ctg aga acg ggc aat aac ttt acc ttc agc tac acc ttc       1248
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe           
                405                 410                 415               

gag gac gtg cct ttc cac agc agc tac gcg cac agc cag agc ctg gac       1296
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp           
            420                 425                 430                   

cgg ctg atg aat cct ctc atc gac cag tac ctg tat tac ctg aac aga       1344
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg           
        435                 440                 445                       

act cag aat cag tcc gga agt gcc caa aac aag gac ttg ctg ttt agc       1392
Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser           
    450                 455                 460                           

cgg ggg tct cca gct ggc atg tct gtt cag ccc aaa aac tgg cta cct       1440
Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro           
465                 470                 475                 480           

gga ccc tgt tac cgg cag cag cgc gtt tct aaa aca aaa aca gac aac       1488
Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn           
                485                 490                 495               

aac aac agc aac ttt acc tgg act ggt gct tca aaa tat aac ctt aat       1536
Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn           
            500                 505                 510                   

ggg cgt gaa tct ata atc aac cct ggc act gct atg gcc tca cac aaa       1584
Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys           
        515                 520                 525                       

gac gac aaa gac aag ttc ttt ccc atg agc ggt gtc atg att ttt gga       1632
Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly           
    530                 535                 540                           

aag gag agc gcc gga gct tca aac act gca ttg gac aat gtc atg atc       1680
Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile           
545                 550                 555                 560           

aca gac gaa gag gaa atc aaa gcc act aac ccc gtg gcc acc gaa aga       1728
Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg           
                565                 570                 575               

ttt ggg act gtg gca gtc aat ctc cag agc agc agc aca gac cct gcg       1776
Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala           
            580                 585                 590                   

acc gga gat gtg cat gtt atg gga gcc tta cct gga atg gtg tgg caa       1824
Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln           
        595                 600                 605                       

gac aga gac gta tac ctg cag ggt cct att tgg gcc aaa att cct cac       1872
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His           
    610                 615                 620                           

acg gat gga cac ttt cac ccg tct cct ctc atg ggc ggc ttt gga ctt       1920
Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu           
625                 630                 635                 640           

aag cac ccg cct cct cag atc ctc atc aaa aac acg cct gtt cct gcg       1968
Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala           
                645                 650                 655               

aat cct ccg gca gag ttt tcg gct aca aag ttt gct tca ttc atc acc       2016
Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr           
            660                 665                 670                   

cag tat tcc aca gga caa gtg agc gtg gag att gaa tgg gag ctg cag       2064
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln           
        675                 680                 685                       

aaa gaa aac agc aaa cgc tgg aat ccc gaa gtg cag tat aca tct aac       2112
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn           
    690                 695                 700                           

tat gca aaa tct gcc aac gtt gat ttc act gtg gac aac aat gga ctt       2160
Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu           
705                 710                 715                 720           

tat act gag cct cgc ccc att ggc acc cgt tac ctc acc cgt ccc ctg       2208
Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu           
                725                 730                 735               

taa                                                                   2211


<210>  2
<211>  736
<212>  PRT
<213>  Adeno-associated virus 6

<400>  2

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  3
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
ggtatggctg ccgatggtta tcttccagat t                                      31


<210>  4
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
accaaaacaa atgttctcgt cacgcgggca tgcttcagat gctgtttccc tgcaaaacat       60

gcgagagaat gaatcagaat ttcaacattt gcttcacgca cgggaccaga gactgttcag      120

aatgtttccc cggcgtgtca gaatctcaac cggtcgtcag aaagaggacg tatcggaaac      180

tctgtgccat tcatcatctg ctggggcggg ctcccgagat tgcttgctcg gcctgcgatc      240

tggtcaacgt ggatctggat gactgtgttt ctgagcaata aatgacttaa accaggtatg      300

gctgccgatg gttatcttcc agatt                                            325


<210>  5
<211>  4286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
gcgcggtgga gtgagcgaag cgcacgctga ggaggatcgg cggccggtga gggggaagca       60

agtctggtct ctgtgattga agaagtcggc tctgggctcc agtgcgggaa tcacacacat      120

acctcaggtg actaatccca agctcggttt ctccaggaac tcactttggt ttgtgtccag      180

tgacatgggt gttcgagagc gggtaggccc cgggctaata cctccctttc ccgtccctgc      240

gcgggaagtg gctggacagc accgccacca cccgcgctgt cgtgggcctc ctcgccggct      300

ccgtgtaggt catcctgtgt tccagaggca tcgttgttcg agcagaggaa tctcgtgaag      360

gaaagtgggc cgagtggatt gtacagcctc tacaatatgc cgaaagtgag aatgccatga      420

cgatggggcg gtctcaggag aacgctgtga caccgtaact cttaaccccg gctcaggacg      480

ctgagcactt tgctttttcc aggcttgaga attccatctt ttcttccgcc ccaacagctc      540

taccaaaaat ttcccctgcg tctcagtgga aaccaaactg gcctcttacc tgagaaacct      600

gtgggacggg caccgtgttg gaaagagcgg ggtccgagta gtttttcatc tgataattga      660

atgagtcacc ccttgaacca aaactaaatg agacttgagt ttattactgt tactatcagt      720

ttgtcgtatt ttggcgacaa tgagaataga actgtgttaa gcatatgtta ggttaactat      780

gttagttaag cataactaaa acctaagata aggatatatt ttcgggttaa atacacagtc      840

atgctgaggt ctctttatcc tcaaaactta ggctttttaa atttttatta agcaaaaaac      900

atggtttctt cgagaaaaag tatagcagag aagtctttat ttcccctcaa ttgagttgtt      960

attcaaggaa caatctctgt caatagtttg ggggtgactt gtacagaact ttgctaccta     1020

ttcttagttc atctggtgcc aaaagatgta gttgtctcat gcacagtaat gtttgtagag     1080

attcggtgat aactttcttt ttcaactata atgatgaaat aaaagcttta cttatgtagc     1140

actcctatac caagaactag cattcagaga gcattcctaa tacgtgttag atccaaatta     1200

gaattatcac gagagttgtc cccatcacat aatatatttt ggaaaggaat gtgaacttct     1260

atatccatta tagcagtttg accatgcact gttttgagaa agaagtccta cctaccattt     1320

gtcatgcaaa ataactgact atgcagggta tttgaaatta gcctggagtt tggttgatat     1380

attttgaaag gtggctgata ctttttacat cagaacacat aagagtatta tagcatgttg     1440

tgatattgag gttctgtggg ttaaagacat tctggatttg atgtcggatt acttgagttt     1500

agctcctacg ctagtactta ttaagcattt gttcttaagg aagtattata atttagtatt     1560

tctgttccac ctttcctgtt cattgcttca ctgtgccctt tcatagtact ttgtattgta     1620

attatttgct tgctagtttg tttcccactc tatacttaat tacttaggta agagtctttt     1680

ttttttttct tttttctttt ttcttttttt ttttgagaca gagtctctgt tgcccaggct     1740

ggagtgtagt ggcacgatct cagctcactg tagcctctgc ccctgggttc aagggattct     1800

cctgcctcag ccactatagt agtgggatta caggtgcctg ccaccacacc cagctaattt     1860

tggtattttt agtagaaatg gggtttcacc atgttgacca ggctggcctc gaactcctgg     1920

tttcaagtga tccacccgcc tcggcctccc aaagtgctgg gattacaggt gtgagccact     1980

gcgcctggcc tggtaagagt ctttcttgtt gtatcattag tgcttagtac atagtagcta     2040

ctgaaaaaaa aattaacaaa ttattatatt acaaaatgga aataccttct ttttctttca     2100

atattttatg tttgactagc acataatggt tttcaaaatg tttttacgta tacatgtgat     2160

accctcagta aacctgtgat gtacatggca cagatgagaa actacagttc aaaggatgtt     2220

atctttccca agcagccact tctagtaagt agcagagcaa ggactggaac acaaggctag     2280

agttgttccc cgagtttact atgttaattg cctgatttga cacttcttga ggaccaaata     2340

aaataagaat gctgtgaaaa agataaagag gtgaagtcac ctagtgtgac ttcgatattg     2400

cggaatgatt tttttaagtt aaaaaaaaaa tttaagttat tagcatttca ttaggcaata     2460

tgttcaaaaa ttgtcaacca atatgcaggt ttttgtggta tggattcttt ttgtacttaa     2520

ctactatcta tctttactat gaataacata ccatcaacag tattccttta cttacccttt     2580

atgttgcaaa gagacttgtg cctcctgaag aaatagtatt catagtcata tcccttcagg     2640

attctcttac atgattgccc atgtttttta accatcaaat taagccttgc ttcccctaaa     2700

agcatcacct ttactgtttg gagaagcttg gtaagtaaat gtggttttca ctggtcaaat     2760

gtcttgcaac tgttccatac atttctgtaa catagtttat ttttatgccc aatttgaaac     2820

tttttagctc tcaaatttga gagctttaca tacacatatt caacaacagt ttccccaccc     2880

ccaccctcga aaagccctgt ttaaaaacga aacaaacagt cagctgtttc ttggtgggta     2940

aggccattga atgtctactt ctctttattt gctaaatccc tattttgtag ggattttgta     3000

ttccctacaa agaaatacat ctctgctact gtcattaata tgctgctctt tgttgtcaaa     3060

cagatgagta ctaatagttt gcacttattg gtgttatgta ctctggcact gaatatatat     3120

taatgttgct ttttaagtaa aatgtttcta attataatat atttatgaat agttttgaga     3180

gaatatagtc ttactgataa gaggacagac tctggatcca gacttcatgg attcaaatcc     3240

tgactcatca cctgttagca gtatgtgaaa gaacaagtaa cttaacctgt gcttcagttt     3300

tttaatctat aaaatgggga gaactaggga gaaagttgta ccacaaggag ataggcaatg     3360

gccagatcat ataggattct gtaggtagtg gaaagataca taagtcagtg ggaagccact     3420

gagaagatat aggcaggtgc caattaataa gttattatat gaattttcac aaggttttct     3480

taggccttta agttctgtta ctacctacgt tttgagcagt gacaacagtg aaggttaaca     3540

gaaaaacatg aaaatcatca gccatgatta gtttgagagc ttcctttttt aaatatgctt     3600

ctacccaggc tatgatttca ggcttgtgga tcataaaagg agtagtgctg aaagtaggtt     3660

gggtggatca aagggaataa ttgtaaatat ctttaatgct tggaggttaa gagaaacttg     3720

aactttgtag taatggagat taaagctatt ctcaagatta ggtataccta ttcaataaaa     3780

gaaaggaata tttgggagta ttggggataa gagaagctag acattgtgaa ttcaaggaaa     3840

aagaattatg agaggaggat gcattttagt ttattttgtg attaaaattt ttttagtttt     3900

tgttgttttg acatgtgaca ctgtaatttt ggctataata aatgacagaa tgtatcattt     3960

ggtatattgg ttagggttta ggtagaaaat tttttccttt atatagtgag tggtagcgta     4020

tacaatgttt gctcacttcg gcaaagagta gctttagttt tctgattagt tataatagtg     4080

atgcttccca tcatttgata tgccttaaag tagtatttta ctcttgaggt attcctttaa     4140

tccttaggtc ttggagtact ttatagatgg tcattatttt ttatgattcc tctgaaacta     4200

aaggcagaga atcacccaag cattacaaaa atgttgagca aaataaaaat taaagcttgg     4260

ttcctgaaca ttatctgttt tctggt                                          4286


<210>  6
<211>  2293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt       60

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      120

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc      180

gacaaggggg agcccgtcaa cgcggcggat gcagcggccc tcgagcacga caaggcctac      240

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag      300

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc      360

caggccaaga agagggttct cgaacctttt ggtctggttg aggaaggtgc taagacggct      420

cctggaaaga aacgtccggt agagcagtcg ccacaagagc cagactcctc ctcgggcatt      480

ggcaagacag gccagcagcc cgctaaaaag agactcaatt ttggtcagac tggcgactca      540

gagtcagtcc ccgacccaca acctctcgga gaacctccag caacccccgc tgctgtggga      600

cctactacaa tggcttcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac atgggccttg cccacctata acaaccacct ctacaagcaa      780

atctccagtg cttcaacggg ggccagcaac gacaaccact acttcggcta cagcaccccc      840

tgggggtatt ttgatttcaa cagattccac tgccatttct caccacgtga ctggcagcga      900

ctcatcaaca acaattgggg attccggccc aagagactca acttcaagct cttcaacatc      960

caagtcaagg aggtcacgac gaatgatggc gtcacgacca tcgctaataa ccttaccagc     1020

acggttcaag tcttctcgga ctcggagtac cagttgccgt acgtcctcgg ctctgcgcac     1080

cagggctgcc tccctccgtt cccggcggac gtgttcatga ttccgcagta cggctaccta     1140

acgctcaaca atggcagcca ggcagtggga cggtcatcct tttactgcct ggaatatttc     1200

ccatcgcaga tgctgagaac gggcaataac tttaccttca gctacacctt cgaggacgtg     1260

cctttccaca gcagctacgc gcacagccag agcctggacc ggctgatgaa tcctctcatc     1320

gaccagtacc tgtattacct gaacagaact cagaatcagt ccggaagtgc ccaaaacaag     1380

gacttgctgt ttagccgggg gtctccagct ggcatgtctg ttcagcccaa aaactggcta     1440

cctggaccct gttaccggca gcagcgcgtt tctaaaacaa aaacagacaa caacaacagc     1500

aactttacct ggactggtgc ttcaaaatat aaccttaatg ggcgtgaatc tataatcaac     1560

cctggcactg ctatggcctc acacaaagac gacaaagaca agttctttcc catgagcggt     1620

gtcatgattt ttggaaagga gagcgccgga gcttcaaaca ctgcattgga caatgtcatg     1680

atcacagacg aagaggaaat caaagccact aaccccgtgg ccaccgaaag atttgggact     1740

gtggcagtca atctccagag cagcagcaca gaccctgcga ccggagatgt gcatgttatg     1800

ggagccttac ctggaatggt gtggcaagac agagacgtat acctgcaggg tcctatttgg     1860

gccaaaattc ctcacacgga tggacacttt cacccgtctc ctctcatggg cggctttgga     1920

cttaagcacc cgcctcctca gatcctcatc aaaaacacgc ctgttcctgc gaatcctccg     1980

gcagagtttt cggctacaaa gtttgcttca ttcatcaccc agtattccac aggacaagtg     2040

agcgtggaga ttgaatggga gctgcagaaa gaaaacagca aacgctggaa tcccgaagtg     2100

cagtatacat ctaactatgc aaaatctgcc aacgttgatt tcactgtgga caacaatgga     2160

ctttatactg agcctcgccc cattggcacc cgttacctca cccgtcccct gtaattgtgt     2220

gttaatcaat aaaccggtta attcgtgtca gttgaacttt ggtctcatgt cgttattatc     2280

ttatctggtc acc                                                        2293


<210>  7
<211>  9761
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
cctcgaagcg gccgccgcgg cctcgaggag cttgccattg catacgttgt atccatatca       60

taatatgtac atttatattg gctcatgtcc aacattaccg ccatgttgac attgattatt      120

gactagttat taatagtaat caattacggg gtcattagtt catagcccat atatggagtt      180

ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc      240

attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg      300

tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat      360

gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca      420

gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat      480

taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt ttgactcacg      540

gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc accaaaatca      600

acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg gcggtaggcg      660

tgtacggtgg gaggtctata taagcagagc tcgtttagtg aaccgtcaga tcgcctggag      720

acgccatcca cgctgttttg acctccatag aagacaccgg gaccgatcca gcctccccgg      780

aagctagcgc ggtggagtga gcgaagcgca cgctgaggag gatcggcggc cggtgagggg      840

gaagcaagtc tggtctctgt gattgaagaa gtcggctctg ggctccagtg cgggaatcac      900

acacatacct caggtgacta atcccaagct cggtttctcc aggaactcac tttggtttgt      960

gtccagtgac atgggtgttc gagagcgggt aggccccggg ctaatacctc cctttcccgt     1020

ccctgcgcgg gaagtggctg gacagcaccg ccaccacccg cgctgtcgtg ggcctcctcg     1080

ccggctccgt gtaggtcatc ctgtgttcca gaggcatcgt tgttcgagca gaggaatctc     1140

gtgaaggaaa gtgggccgag tggattgtac agcctctaca atatgccgaa agtgagaatg     1200

ccatgacgat ggggcggtct caggagaacg ctgtgacacc gtaactctta accccggctc     1260

aggacgctga gcactttgct ttttccaggc ttgagaattc catcttttct tccgccccaa     1320

cagctctacc aaaaatttcc cctgcgtctc agtggaaacc aaactggcct cttacctgag     1380

aaacctgtgg gacgggcacc gtgttggaaa gagcggggtc cgagtagttt ttcatctgat     1440

aattgaatga gtcacccctt gaaccaaaac taaatgagac ttgagtttat tactgttact     1500

atcagtttgt cgtattttgg cgacaatgag aatagaactg tgttaagcat atgttaggtt     1560

aactatgtta gttaagcata actaaaacct aagataagga tatattttcg ggttaaatac     1620

acagtcatgc tgaggtctct ttatcctcaa aacttaggct ttttaaattt ttattaagca     1680

aaaaacatgg tttcttcgag aaaaagtata gcagagaagt ctttatttcc cctcaattga     1740

gttgttattc aaggaacaat ctctgtcaat agtttggggg tgacttgtac agaactttgc     1800

tacctattct tagttcatct ggtgccaaaa gatgtagttg tctcatgcac agtaatgttt     1860

gtagagattc ggtgataact ttctttttca actataatga tgaaataaaa gctttactta     1920

tgtagcactc ctataccaag aactagcatt cagagagcat tcctaatacg tgttagatcc     1980

aaattagaat tatcacgaga gttgtcccca tcacataata tattttggaa aggaatgtga     2040

acttctatat ccattatagc agtttgacca tgcactgttt tgagaaagaa gtcctaccta     2100

ccatttgtca tgcaaaataa ctgactatgc agggtatttg aaattagcct ggagtttggt     2160

tgatatattt tgaaaggtgg ctgatacttt ttacatcaga acacataaga gtattatagc     2220

atgttgtgat attgaggttc tgtgggttaa agacattctg gatttgatgt cggattactt     2280

gagtttagct cctacgctag tacttattaa gcatttgttc ttaaggaagt attataattt     2340

agtatttctg ttccaccttt cctgttcatt gcttcactgt gccctttcat agtactttgt     2400

attgtaatta tttgcttgct agtttgtttc ccactctata cttaattact taggtaagag     2460

tctttttttt ttttcttttt tcttttttct tttttttttt gagacagagt ctctgttgcc     2520

caggctggag tgtagtggca cgatctcagc tcactgtagc ctctgcccct gggttcaagg     2580

gattctcctg cctcagccac tatagtagtg ggattacagg tgcctgccac cacacccagc     2640

taattttggt atttttagta gaaatggggt ttcaccatgt tgaccaggct ggcctcgaac     2700

tcctggtttc aagtgatcca cccgcctcgg cctcccaaag tgctgggatt acaggtgtga     2760

gccactgcgc ctggcctggt aagagtcttt cttgttgtat cattagtgct tagtacatag     2820

tagctactga aaaaaaaatt aacaaattat tatattacaa aatggaaata ccttcttttt     2880

ctttcaatat tttatgtttg actagcacat aatggttttc aaaatgtttt tacgtataca     2940

tgtgataccc tcagtaaacc tgtgatgtac atggcacaga tgagaaacta cagttcaaag     3000

gatgttatct ttcccaagca gccacttcta gtaagtagca gagcaaggac tggaacacaa     3060

ggctagagtt gttccccgag tttactatgt taattgcctg atttgacact tcttgaggac     3120

caaataaaat aagaatgctg tgaaaaagat aaagaggtga agtcacctag tgtgacttcg     3180

atattgcgga atgatttttt taagttaaaa aaaaaattta agttattagc atttcattag     3240

gcaatatgtt caaaaattgt caaccaatat gcaggttttt gtggtatgga ttctttttgt     3300

acttaactac tatctatctt tactatgaat aacataccat caacagtatt cctttactta     3360

ccctttatgt tgcaaagaga cttgtgcctc ctgaagaaat agtattcata gtcatatccc     3420

ttcaggattc tcttacatga ttgcccatgt tttttaacca tcaaattaag ccttgcttcc     3480

cctaaaagca tcacctttac tgtttggaga agcttggtaa gtaaatgtgg ttttcactgg     3540

tcaaatgtct tgcaactgtt ccatacattt ctgtaacata gtttattttt atgcccaatt     3600

tgaaactttt tagctctcaa atttgagagc tttacataca catattcaac aacagtttcc     3660

ccacccccac cctcgaaaag ccctgtttaa aaacgaaaca aacagtcagc tgtttcttgg     3720

tgggtaaggc cattgaatgt ctacttctct ttatttgcta aatccctatt ttgtagggat     3780

tttgtattcc ctacaaagaa atacatctct gctactgtca ttaatatgct gctctttgtt     3840

gtcaaacaga tgagtactaa tagtttgcac ttattggtgt tatgtactct ggcactgaat     3900

atatattaat gttgcttttt aagtaaaatg tttctaatta taatatattt atgaatagtt     3960

ttgagagaat atagtcttac tgataagagg acagactctg gatccagact tcatggattc     4020

aaatcctgac tcatcacctg ttagcagtat gtgaaagaac aagtaactta acctgtgctt     4080

cagtttttta atctataaaa tggggagaac tagggagaaa gttgtaccac aaggagatag     4140

gcaatggcca gatcatatag gattctgtag gtagtggaaa gatacataag tcagtgggaa     4200

gccactgaga agatataggc aggtgccaat taataagtta ttatatgaat tttcacaagg     4260

ttttcttagg cctttaagtt ctgttactac ctacgttttg agcagtgaca acagtgaagg     4320

ttaacagaaa aacatgaaaa tcatcagcca tgattagttt gagagcttcc ttttttaaat     4380

atgcttctac ccaggctatg atttcaggct tgtggatcat aaaaggagta gtgctgaaag     4440

taggttgggt ggatcaaagg gaataattgt aaatatcttt aatgcttgga ggttaagaga     4500

aacttgaact ttgtagtaat ggagattaaa gctattctca agattaggta tacctattca     4560

ataaaagaaa ggaatatttg ggagtattgg ggataagaga agctagacat tgtgaattca     4620

aggaaaaaga attatgagag gaggatgcat tttagtttat tttgtgatta aaattttttt     4680

agtttttgtt gttttgacat gtgacactgt aattttggct ataataaatg acagaatgta     4740

tcatttggta tattggttag ggtttaggta gaaaattttt tcctttatat agtgagtggt     4800

agcgtataca atgtttgctc acttcggcaa agagtagctt tagttttctg attagttata     4860

atagtgatgc ttcccatcat ttgatatgcc ttaaagtagt attttactct tgaggtattc     4920

ctttaatcct taggtcttgg agtactttat agatggtcat tattttttat gattcctctg     4980

aaactaaagg cagagaatca cccaagcatt acaaaaatgt tgagcaaaat aaaaattaaa     5040

gcttggttcc tgaacattat ctgttttctg gtaccaaaac aaatgttctc gtcacgcggg     5100

catgcttcag atgctgtttc cctgcaaaac atgcgagaga atgaatcaga atttcaacat     5160

ttgcttcacg cacgggacca gagactgttc agaatgtttc cccggcgtgt cagaatctca     5220

accggtcgtc agaaagagga cgtatcggaa actctgtgcc attcatcatc tgctggggcg     5280

ggctcccgag attgcttgct cggcctgcga tctggtcaac gtggatctgg atgactgtgt     5340

ttctgagcaa taaatgactt aaaccaggta tggctgccga tggttatctt ccagattggc     5400

tcgaggacaa cctctctgag ggcattcgcg agtggtggga cttgaaacct ggagccccga     5460

aacccaaagc caaccagcaa aagcaggacg acggccgggg tctggtgctt cctggctaca     5520

agtacctcgg acccttcaac ggactcgaca agggggagcc cgtcaacgcg gcggatgcag     5580

cggccctcga gcacgacaag gcctacgacc agcagctcaa agcgggtgac aatccgtacc     5640

tgcggtataa ccacgccgac gccgagtttc aggagcgtct gcaagaagat acgtcttttg     5700

ggggcaacct cgggcgagca gtcttccagg ccaagaagag ggttctcgaa ccttttggtc     5760

tggttgagga aggtgctaag acggctcctg gaaagaaacg tccggtagag cagtcgccac     5820

aagagccaga ctcctcctcg ggcattggca agacaggcca gcagcccgct aaaaagagac     5880

tcaattttgg tcagactggc gactcagagt cagtccccga cccacaacct ctcggagaac     5940

ctccagcaac ccccgctgct gtgggaccta ctacaatggc ttcaggcggt ggcgcaccaa     6000

tggcagacaa taacgaaggc gccgacggag tgggtaatgc ctcaggaaat tggcattgcg     6060

attccacatg gctgggcgac agagtcatca ccaccagcac ccgaacatgg gccttgccca     6120

cctataacaa ccacctctac aagcaaatct ccagtgcttc aacgggggcc agcaacgaca     6180

accactactt cggctacagc accccctggg ggtattttga tttcaacaga ttccactgcc     6240

atttctcacc acgtgactgg cagcgactca tcaacaacaa ttggggattc cggcccaaga     6300

gactcaactt caagctcttc aacatccaag tcaaggaggt cacgacgaat gatggcgtca     6360

cgaccatcgc taataacctt accagcacgg ttcaagtctt ctcggactcg gagtaccagt     6420

tgccgtacgt cctcggctct gcgcaccagg gctgcctccc tccgttcccg gcggacgtgt     6480

tcatgattcc gcagtacggc tacctaacgc tcaacaatgg cagccaggca gtgggacggt     6540

catcctttta ctgcctggaa tatttcccat cgcagatgct gagaacgggc aataacttta     6600

ccttcagcta caccttcgag gacgtgcctt tccacagcag ctacgcgcac agccagagcc     6660

tggaccggct gatgaatcct ctcatcgacc agtacctgta ttacctgaac agaactcaga     6720

atcagtccgg aagtgcccaa aacaaggact tgctgtttag ccgggggtct ccagctggca     6780

tgtctgttca gcccaaaaac tggctacctg gaccctgtta ccggcagcag cgcgtttcta     6840

aaacaaaaac agacaacaac aacagcaact ttacctggac tggtgcttca aaatataacc     6900

ttaatgggcg tgaatctata atcaaccctg gcactgctat ggcctcacac aaagacgaca     6960

aagacaagtt ctttcccatg agcggtgtca tgatttttgg aaaggagagc gccggagctt     7020

caaacactgc attggacaat gtcatgatca cagacgaaga ggaaatcaaa gccactaacc     7080

ccgtggccac cgaaagattt gggactgtgg cagtcaatct ccagagcagc agcacagacc     7140

ctgcgaccgg agatgtgcat gttatgggag ccttacctgg aatggtgtgg caagacagag     7200

acgtatacct gcagggtcct atttgggcca aaattcctca cacggatgga cactttcacc     7260

cgtctcctct catgggcggc tttggactta agcacccgcc tcctcagatc ctcatcaaaa     7320

acacgcctgt tcctgcgaat cctccggcag agttttcggc tacaaagttt gcttcattca     7380

tcacccagta ttccacagga caagtgagcg tggagattga atgggagctg cagaaagaaa     7440

acagcaaacg ctggaatccc gaagtgcagt atacatctaa ctatgcaaaa tctgccaacg     7500

ttgatttcac tgtggacaac aatggacttt atactgagcc tcgccccatt ggcacccgtt     7560

acctcacccg tcccctgtaa ttgtgtgtta atcaataaac cggttaattc gtgtcagttg     7620

aactttggtc tcatgtcgtt attatcttat ctggtcacca gatccccggg taccgaggat     7680

ctaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca     7740

caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat     7800

cttatcatgt ctggatccgg ccgcggcggc cgcgatccga cgcgaggctg gatggccttc     7860

cccattatga ttcttctcgc ttccggcggc atcgggatgc ccgcgttgca ggccatgctg     7920

tccaggcagg tagatgacga ccatcaggga cagcttcaaa aaggccagca aaaggccagg     7980

aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat     8040

cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag     8100

gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga     8160

tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg     8220

tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt     8280

cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac     8340

gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc     8400

ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt     8460

ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc     8520

ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc     8580

agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg     8640

aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag     8700

atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg     8760

tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt     8820

tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca     8880

tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca     8940

gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc     9000

tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt     9060

ttgcgcaacg ttgttgccat tgctgcaggc atcgtggtgt cacgctcgtc gtttggtatg     9120

gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc     9180

aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg     9240

ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga     9300

tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga     9360

ccgagttgct cttgcccggc gtcaacacgg gataataccg cgccacatag cagaacttta     9420

aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg     9480

ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact     9540

ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata     9600

agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt     9660

tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa     9720

ataggggttc cgcgcacatt tccccgaaaa gtgccacctg c                         9761


<210>  8
<211>  2208
<212>  DNA
<213>  Adeno-associated virus 2


<220>
<221>  CDS
<222>  (1)..(2208)

<400>  8
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac act ctc tct         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser           
1               5                   10                  15                

gaa gga ata aga cag tgg tgg aag ctc aaa cct ggc cca cca cca cca         96
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro           
            20                  25                  30                    

aag ccc gca gag cgg cat aag gac gac agc agg ggt ctt gtg ctt cct        144
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggg tac aag tac ctc gga ccc ttc aac gga ctc gac aag gga gag ccg        192
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gag gca gac gcc gcg gcc ctc gag cac gac aaa gcc tac gac        240
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cgg cag ctc gac agc gga gac aac ccg tac ctc aag tac aac cac gcc        288
Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala           
                85                  90                  95                

gac gcg gag ttt cag gag cgc ctt aaa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc gga cga gca gtc ttc cag gcg aaa aag agg gtt ctt gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro           
        115                 120                 125                       

ctg ggc ctg gtt gag gaa cct gtt aag acg gct ccg gga aaa aag agg        432
Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

ccg gta gag cac tct cct gtg gag cca gac tcc tcc tcg gga acc gga        480
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly           
145                 150                 155                 160           

aag gcg ggc cag cag cct gca aga aaa aga ttg aat ttt ggt cag act        528
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr           
                165                 170                 175               

gga gac gca gac tca gta cct gac ccc cag cct ctc gga cag cca cca        576
Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro           
            180                 185                 190                   

gca gcc ccc tct ggt ctg gga act aat acg atg gct aca ggc agt ggc        624
Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly           
        195                 200                 205                       

gca cca atg gca gac aat aac gag ggc gcc gac gga gtg ggt aat tcc        672
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser           
    210                 215                 220                           

tcg gga aat tgg cat tgc gat tcc aca tgg atg ggc gac aga gtc atc        720
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile           
225                 230                 235                 240           

acc acc agc acc cga acc tgg gcc ctg ccc acc tac aac aac cac ctc        768
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu           
                245                 250                 255               

tac aaa caa att tcc agc caa tca gga gcc tcg aac gac aat cac tac        816
Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr           
            260                 265                 270                   

ttt ggc tac agc acc cct tgg ggg tat ttt gac ttc aac aga ttc cac        864
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His           
        275                 280                 285                       

tgc cac ttt tca cca cgt gac tgg caa aga ctc atc aac aac aac tgg        912
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp           
    290                 295                 300                           

gga ttc cga ccc aag aga ctc aac ttc aag ctc ttt aac att caa gtc        960
Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val           
305                 310                 315                 320           

aaa gag gtc acg cag aat gac ggt acg acg acg att gcc aat aac ctt       1008
Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu           
                325                 330                 335               

acc agc acg gtt cag gtg ttt act gac tcg gag tac cag ctc ccg tac       1056
Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr           
            340                 345                 350                   

gtc ctc ggc tcg gcg cat caa gga tgc ctc ccg ccg ttc cca gca gac       1104
Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp           
        355                 360                 365                       

gtc ttc atg gtg cca cag tat gga tac ctc acc ctg aac aac ggg agt       1152
Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser           
    370                 375                 380                           

cag gca gta gga cgc tct tca ttt tac tgc ctg gag tac ttt cct tct       1200
Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser           
385                 390                 395                 400           

cag atg ctg cgt acc gga aac aac ttt acc ttc agc tac act ttt gag       1248
Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu           
                405                 410                 415               

gac gtt cct ttc cac agc agc tac gct cac agc cag agt ctg gac cgt       1296
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg           
            420                 425                 430                   

ctc atg aat cct ctc atc gac cag tac ctg tat tac ttg agc aga aca       1344
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr           
        435                 440                 445                       

aac act cca agt gga acc acc acg cag tca agg ctt cag ttt tct cag       1392
Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln           
    450                 455                 460                           

gcc gga gcg agt gac att cgg gac cag tct agg aac tgg ctt cct gga       1440
Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly           
465                 470                 475                 480           

ccc tgt tac cgc cag cag cga gta tca aag aca tct gcg gat aac aac       1488
Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn           
                485                 490                 495               

aac agt gaa tac tcg tgg act gga gct acc aag tac cac ctc aat ggc       1536
Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly           
            500                 505                 510                   

aga gac tct ctg gtg aat ccg ggc ccg gcc atg gca agc cac aag gac       1584
Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp           
        515                 520                 525                       

gat gaa gaa aag ttt ttt cct cag agc ggg gtt ctc atc ttt ggg aag       1632
Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys           
    530                 535                 540                           

caa ggc tca gag aaa aca aat gtg gac att gaa aag gtc atg att aca       1680
Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr           
545                 550                 555                 560           

gac gaa gag gaa atc agg aca acc aat ccc gtg gct acg gag cag tat       1728
Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr           
                565                 570                 575               

ggt tct gta tct acc aac ctc cag aga ggc aac aga caa gca gct acc       1776
Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr           
            580                 585                 590                   

gca gat gtc aac aca caa ggc gtt ctt cca ggc atg gtc tgg cag gac       1824
Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp           
        595                 600                 605                       

aga gat gtg tac ctt cag ggg ccc atc tgg gca aag att cca cac acg       1872
Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr           
    610                 615                 620                           

gac gga cat ttt cac ccc tct ccc ctc atg ggt gga ttc gga ctt aaa       1920
Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys           
625                 630                 635                 640           

cac cct cct cca cag att ctc atc aag aac acc ccg gta cct gcg aat       1968
His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn           
                645                 650                 655               

cct tcg acc acc ttc agt gcg gca aag ttt gct tcc ttc atc aca cag       2016
Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln           
            660                 665                 670                   

tac tcc acg gga cag gtc agc gtg gag atc gag tgg gag ctg cag aag       2064
Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys           
        675                 680                 685                       

gaa aac agc aaa cgc tgg aat ccc gaa att cag tac act tcc aac tac       2112
Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr           
    690                 695                 700                           

aac aag tct gtt aat gtg gac ttt act gtg gac act aat ggc gtg tat       2160
Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr           
705                 710                 715                 720           

tca gag cct cgc ccc att ggc acc aga tac ctg act cgt aat ctg taa       2208
Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu               
                725                 730                 735               


<210>  9
<211>  735
<212>  PRT
<213>  Adeno-associated virus 2

<400>  9

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
cggggtttta cgagattgtg                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
cgccatttct ggtctttgtg                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
ccacaagagc cagactcctc                                                   20


<210>  13
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
gccatcattc gtcgtgacc                                                    19


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
ccactgtatt gagcctgatg ttaaa                                             25


<210>  15
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
gctctgtatg ttccctcttc tcggt                                             25


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
gcgttaactc ggcgtttcat                                                   20


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
gcgctcaggt caaattcaga c                                                 21


<210>  18
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
ggctagcgcg gtggagtgag cgaag                                             25


<210>  19
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
ggctagcttc tgcaatttaa acaaaag                                           27


