                         SEQUENCE LISTING

<110>  Altimab Therapeutics, Inc.
       Li, Zijuan
       Wu, Chun
       Bao, Jun
       Chen, Bo
 
<120>  PROTEIN COMPLEXES FOR ANTIGEN BINDING AND METHODS OF USE

<130>  035268-8001WO01

<150>  US 61/411,903
<151>  2010-11-09

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  1
gaagttcaac ttcttgaaca atctggtgct gaacttgctc gtcctggtgc ttc              53


<210>  2
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  2
gtataaccag aagctttaca agaaagttta acagaagcac caggacgagc aag              53


<210>  3
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  3
gtaaagcttc tggttatact tttactaatt atggtctttc ttgggttaaa caacgt           56


<210>  4
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  4
ggataaactt caccaatcca ttcaagaact tgaccaggac gttgtttaac ccaagaaag        59


<210>  5
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  5
ggattggtga agtttatcct cgtattggta atgcttatta taatgaaaaa tttaaagg         58


<210>  6
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  6
gaagaagatt tatcagcagt aagagtagct ttacctttaa atttttcatt ataataag         58


<210>  7
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  7
ctgctgataa atcttcttct actgcttcta tggaacttcg ttctcttact tctg             54


<210>  8
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  8
gaaccacgac gagcacaaaa ataaacagca gaatcttcag aagtaagaga acgaag           56


<210>  9
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  9
ttttgtgctc gtcgtggttc ttatgatact aattatgatt ggtattttga tgtttggg         58


<210>  10
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  10
gccaccgcca ccagaagaaa cagtaacagt agtaccttga ccccaaacat caaaatac         58


<210>  11
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  11
gtttcttctg gtggcggtgg cagcggcggt ggtgggtccg gtggcggcgg atctgaac         58


<210>  12
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  12
gagaaacagg aagagaaaga ggagtttgag tcataacaag ttcagatccg ccgccac          57


<210>  13
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  13
ctttctcttc ctgtttctct tggtgatcaa gcttctattt cttgtcgttc ttctcaatc        59


<210>  14
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  14
ccaatgaaga taagtattac cattagaatg aacaagagat tgagaagaac gacaag           56


<210>  15
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  15
gtaatactta tcttcattgg tatcttcaaa aacctggtca atctcctaaa cttc             54


<210>  16
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  16
caggaacacc agaaaaacga ttagaaactt tataaataag aagtttagga gattgac          57


<210>  17
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  17
gtttttctgg tgttcctgat cgtttttctg gttctggttc tggtactgat tttactc          57


<210>  18
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  18
caccaagatc ttcagcttca acacgagaaa ttttaagagt aaaatcagta ccag             54


<210>  19
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  19
gaagctgaag atcttggtgt ttatttttgt tctcaatcta ctcatgttcc ttatac           56


<210>  20
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  20
tttcaagttt agtaccacca ccaaaagtat aaggaacatg agtag                       45


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  21
gaagttcaac ttcttgaaca atc                                               23


<210>  22
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  22
caaaagtata aggaacatga gtag                                              24


<210>  23
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  23
gagacgtacg caggtccagc tgcagcagtc tggggctgaa ctggcaagac ctggggcctc       60


<210>  24
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  24
cctagtaaag gtgtagccag aagccttgca ggacatcttc actgaggccc caggtcttg        59


<210>  25
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  25
ctggctacac ctttactagg tacacgatgc actgggtaaa acagaggcct ggacaggg         58


<210>  26
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  26
ccacggctag gattaatgta tccaatccat tccagaccct gtccaggcct ctgttttac        59


<210>  27
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  27
cattaatcct agccgtggtt atactaatta caatcagaag ttcaaggaca aggccac          57


<210>  28
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  28
gttgcatgta ggctgtgctg gaggatttgt ctgtagtcaa tgtggccttg tccttgaac        59


<210>  29
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  29
cagcacagcc tacatgcaac tgagcagcct gacatctgag gactctgcag tctattac         58


<210>  30
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  30
gtagtcaagg cagtaatgat catcataata tcttgcacag taatagactg cagagtcc         58


<210>  31
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  31
gatcattact gccttgacta ctggggccaa ggcaccactc tcacagtctc ctcagc           56


<210>  32
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  32
gagagctagc tgaggagact gtgaga                                            26


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  33
gagacgtacg caggtccagc                                                   20


<210>  34
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  34
gctgaggaga ctgtgaga                                                     18


<210>  35
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  35
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtc          57


<210>  36
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  36
catgtaactt acacttgagc tggcactgca ggtcatggtg accttctccc ctggagatg        59


<210>  37
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  37
gctcaagtgt aagttacatg aactggtacc agcagaagtc aggcacctcc cccaaaag         58


<210>  38
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  38
gactccagaa gccagtttgg atgtgtcata aatccatctt ttgggggagg tgcctgac         58


<210>  39
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  39
caaactggct tctggagtcc ctgctcactt caggggcagt gggtctggga cctcttac         58


<210>  40
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  40
gtggcagcat cttcagcctc catgccgctg attgtgagag agtaagaggt cccagacc         58


<210>  41
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  41
gaggctgaag atgctgccac ttattactgc cagcagtgga gtagtaaccc attcacg          57


<210>  42
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  42
gagacgtacg gtttatttcc aactttgtcc ccgagccgaa cgtgaatggg ttactactc        59


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  43
caaattgttc tcacccagtc                                                   20


<210>  44
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  44
cgtgaatggg ttactactc                                                    19


<210>  45
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  45
gctagcacca agggcccatc cg                                                22


<210>  46
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  46
tttccccgga gacagggag                                                    19


<210>  47
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  47
cgtacggtgg ctgcaccatc tgtcttcatc                                        30


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  48
acactctccc ctgttgaagc                                                   20


<210>  49
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  49
actcacacat gcccaccgtg cccagcacca cgtacgcagg tccagctgca gcagtc           56


<210>  50
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  50
gatgggccct tggtgctagc tgaggagact gtgagagtgg                             40


<210>  51
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  51
gagaggatcc tcaagttttg tcacaagatt tgggctc                                37


<210>  52
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  52
ctttttcttg tggctatttt aaaaggtgtc cagtgtgggg gaccgtcagt cttcc            55


<210>  53
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  53
gccaccggat ccatggagtt tgggctgagc tggctttttc ttgtggctat tttaaaag         58


<210>  54
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  54
cggtgggcat gtgtgagttt tccccggaga cagggagagg                             40


<210>  55
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  55
ctttttcttg tggctatttt aaaaggtgtc cagtgtgaag ttcaacttct tgaacaatc        59


<210>  56
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  56
gaggaagact gacggtcccc ctttaatttc aagtttagta c                           41


<210>  57
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  57
gtactaaact tgaaattaaa gggggaccgt cagtcttcct c                           41


<210>  58
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  58
ctttttcttg tggctatttt aaaaggtgtc cagtgtcaaa ttgttctcac ccagtc           56


<210>  59
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  59
gatggtgcag ccaccgtacg gtttatttcc aactttgtc                              39


<210>  60
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  60
gacaaagttg gaaataaacc gtacggtggc tgcaccatc                              39


<210>  61
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  61
gagaggatcc acactctccc ctgttgaagc                                        30


<210>  62
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region for humanized antibody mab 240.g1

<400>  62
gaggtgcaaa ttttggagac tggaggaggc ttggtgaagc ccggtggttc cctgagactg       60

tcttgtgcaa cgtctggatt caacttcaat gattatttca tgaactgggt ccgtcaggct      120

ccagggaagg gactagagtg gcttgctcaa atgagaaaca aaaattatca atatggcaca      180

tattatgcgg agtctttgga aggcagagtc acagtctcac gagacgatgc caaaaacagt      240

gtctacctgc aagtgagcag tttaagagct gaggacacgg ccatttatta ctgtacaaga      300

gagtcatact acggctttac ctcctactgg ggccaaggag tcatggtcac agtctcg         357


<210>  63
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region for humanized antibody mab 240.g1

<400>  63
gacatccaga tgacacagtc tcctgcctcc ctgtctgcat ctctggaaga aattgtcacc       60

atcacatgcc aggcaagcca ggacattggt atttctttat catggtatca gcagaaacca      120

gggaggactc ctcagctcct gatccaaaat gcaaacaact tggcagatgg ggtcccatca      180

aggttcagcg gccgtagatt tggcacacag ttttctctta cgatcagtac accacaggtt      240

gaagatactg gagtctatta ctgtctccag cataatagtg ctccgtacac gtttggaact      300

gggacccagc tggaaatcaa a                                                321


<210>  64
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region for humanized antibody IZI-06.1

<400>  64
caggttcagc tggttcagag cggtgcggaa gtgaaaaaac cgggcagcag cgtgaaagtg       60

agctgcaaag cgagcggcta tacctttacc gatttctaca ttaactgggt gcgtcaggca      120

ccgggtcagg gcctggaatg gattggcgaa atttatccgt atagcggcca tgcatattac      180

aacgaaaaat tcaaagcgcg tgtgaccatt accgcggata aaagcaccag caccgcgtat      240

atggaactga gcagcctgcg tagcgaagat accgcggtgt attattgcgc gcgttgggat      300

tttctggatt attggggcca gggcaccacc gttacggtct cgagt                      345


<210>  65
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region for humanized antibody IZI-06.1

<400>  65
gatattgtga tgacccagag cccgctgtct ctgccggtca cgccgggtga accggcgagc       60

attagctgcc gtagcagcca gagcctgctg catagcaacg gcaacaccta tctgcattgg      120

tatctgcaga aaccgggcca gagcccgcag ctgctgattt ataccgtgag caaccgtttt      180

agcggcgtgc cggatcgctt tagcggcagc ggtagcggca ccgattttac cctgaaaatt      240

agccgtgtgg aagcggaaga tgtgggcgtg tattattgca gccagagcac ccatgtgccg      300

tatacctttg gcggtggcac caaagtggaa attaaacgt                             339


<210>  66
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region for humanized antibody 300N

<400>  66
gagatgcaac tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agtcactgga tgaagtgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgttt      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatatt      300

gtactaatgg tctatgatat ggactactac tactacggta tggacgtctg gggccaaggg      360

accacggtca ccgtctcctc a                                                381


<210>  67
<211>  335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region for humanized antibody 300N

<400>  67
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctca       60

tctcctgcag gtctagtcag agcctcctgc atagtaatgg aaacaactat ttggattggt      120

acctgcagaa gccagggcag tctccacagc tcctgatcta tttgggttct aatcgggcct      180

ccggggtccc tgacaggttc agtggcagtg gatcaggcac agattttaca ctgaaaatca      240

gcagagtgga ggctgaggat gttggggttt attactgcat gcaaactcta caaactccgc      300

tcactttcgg cggagggacc aaggtggaga tcaaa                                 335


<210>  68
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  68

Cys Pro Pro Cys 
1               


<210>  69
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  69

Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
1               5                   10  


<210>  70
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  70

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
1               5                   10          


