
                                SEQUENCE LISTING

<110> Isis Pharmaceuticals, Inc.
      Brett P. Monia
      Robert A. MacLeod
      Jeffrey R. Crosby

<120> METHODS FOR MODULATING FACTOR 12
      EXPRESSION

<130> BIOL0138WO

<150> 61/411,309
<151> 2010-11-08

<160> 19

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 2060
<212> DNA
<213> H. sapiens

<400> 1
ctattgatct ggactcctgg ataggcagct ggaccaacgg acggatgcca tgagggctct 60
gctgctcctg gggttcctgc tggtgagctt ggagtcaaca ctttcgattc caccttggga 120
agcccccaag gagcataagt acaaagctga agagcacaca gtcgttctca ctgtcaccgg 180
ggagccctgc cacttcccct tccagtacca ccggcagctg taccacaaat gtacccacaa 240
gggccggcca ggccctcagc cctggtgtgc taccaccccc aactttgatc aggaccagcg 300
atggggatac tgtttggagc ccaagaaagt gaaagaccac tgcagcaaac acagcccctg 360
ccagaaagga gggacctgtg tgaacatgcc aagcggcccc cactgtctct gtccacaaca 420
cctcactgga aaccactgcc agaaagagaa gtgctttgag cctcagcttc tccggttttt 480
ccacaagaat gagatatggt atagaactga gcaagcagct gtggccagat gccagtgcaa 540
gggtcctgat gcccactgcc agcggctggc cagccaggcc tgccgcacca acccgtgcct 600
ccatgggggt cgctgcctag aggtggaggg ccaccgcctg tgccactgcc cggtgggcta 660
caccggagcc ttctgcgacg tggacaccaa ggcaagctgc tatgatggcc gcgggctcag 720
ctaccgcggc ctggccagga ccacgctctc gggtgcgccc tgtcagccgt gggcctcgga 780
ggccacctac cggaacgtga ctgccgagca agcgcggaac tggggactgg gcggccacgc 840
cttctgccgg aacccggaca acgacatccg cccgtggtgc ttcgtgctga accgcgaccg 900
gctgagctgg gagtactgcg acctggcaca gtgccagacc ccaacccagg cggcgcctcc 960
gaccccggtg tcccctaggc ttcatgtccc actcatgccc gcgcagccgg caccgccgaa 1020
gcctcagccc acgacccgga ccccgcctca gtcccagacc ccgggagcct tgccggcgaa 1080
gcgggagcag ccgccttccc tgaccaggaa cggcccactg agctgcgggc agcggctccg 1140
caagagtctg tcttcgatga cccgcgtcgt tggcgggctg gtggcgctac gcggggcgca 1200
cccctacatc gccgcgctgt actggggcca cagtttctgc gccggcagcc tcatcgcccc 1260
ctgctgggtg ctgacggccg ctcactgcct gcaggaccgg cccgcacccg aggatctgac 1320
ggtggtgctc ggccaggaac gccgtaacca cagctgtgag ccgtgccaga cgttggccgt 1380
gcgctcctac cgcttgcacg aggccttctc gcccgtcagc taccagcacg acctggctct 1440
gttgcgcctt caggaggatg cggacggcag ctgcgcgctc ctgtcgcctt acgttcagcc 1500
ggtgtgcctg ccaagcggcg ccgcgcgacc ctccgagacc acgctctgcc aggtggccgg 1560
ctggggccac cagttcgagg gggcggagga atatgccagc ttcctgcagg aggcgcaggt 1620
accgttcctc tccctggagc gctgctcagc cccggacgtg cacggatcct ccatcctccc 1680
cggcatgctc tgcgcagggt tcctcgaggg cggcaccgat gcgtgccagg gtgattccgg 1740
aggcccgctg gtgtgtgagg accaagctgc agagcgccgg ctcaccctgc aaggcatcat 1800
cagctgggga tcgggctgtg gtgaccgcaa caagccaggc gtctacaccg atgtggccta 1860
ctacctggcc tggatccggg agcacaccgt ttcctgattg ctcagggact catctttccc 1920
tccttggtga ttccgcagtg agagagtggc tggggcatgg aaggcaagat tgtgtcccat 1980
tcccccagtg cggccagctc cgcgccagga tggcgcagga actcaataaa gtgctttgaa 2040
aatgctgaga aaaaaaaaaa                                             2060

<210> 2
<211> 1961
<212> DNA
<213> Mus musculus

<400> 2
tcctgggcag gcagcggggc catcggcaga cgccatgacg gctctgttgt tcctggggtc 60
tctgctgatg agtctggatc tgacactttc ggctccacca tggaaagact ccaagaaatt 120
taaggacgca cctgatgggc ccacagtggt tctcactgtg gatgggaggc tctgccattt 180
tccctttcag taccaccgtc agctacacca caaatgcatc cacaaaaggc ggccaggctc 240
ccgcccctgg tgtgctacca cccccaactt tgatgaagat cagcaatggg gatactgctt 300
ggagcccaag aaagtgaaag accattgcag caaacacaac ccgtgccaca aaggagggac 360
atgtatcaac acccccaatg ggccacactg tctctgccct gaacacctca ctgggaaaca 420
ttgccagaaa gagaaatgct ttgagcctca gcttctcaag ttcttccacg agaatgagct 480
atggtttaga acggggccag gaggtgtggc caggtgcgag tgcaaaggtt ctgaggctca 540
ctgcaagccg gtggccagcc aggcctgcag catcaatccg tgccttaatg ggggcagctg 600
cctcctcgtg gaggaccacc cactgtgccg ttgccctaca ggctacactg gatatttttg 660
cgacttggac ctttgggcga cctgctatga aggcaggggg ctcagctacc ggggccaggc 720
tggaactacg caatcgggtg cgccatgtca gcggtggacc gtggaggcca cctaccggaa 780
catgactgag aagcaagcgc taagctgggg cctgggccac cacgcatttt gccggaaccc 840
agataatgac acacgtccat ggtgcttcgt ctggagtggc gacaggctga gctgggacta 900
ttgcggcctg gagcagtgcc agacgccaac gtttgcacct ctagttgtcc ctgagagtca 960
ggaggagtcc ccgtcccagg caccatctct gtcccatgca ccaaatgact cgaccgatca 1020
tcagacttct ctgtccaaga ccaacacgat gggctgcgga cagaggttcc gcaagggact 1080
gtcctcgttc atgcgcgtgg tgggcggact agtggctctg cctgggtcgc acccctacat 1140
cgctgcactg tactggggta acaacttctg cgcgggcagt ctcatcgccc cctgttgggt 1200
gctgaccgcg gctcactgcc tgcagaatcg gccagcgccc gaggaactga cagtggtact 1260
tggtcaagat cgccacaacc agagctgcga gtggtgccag actctggctg tgcgctccta 1320
ccgccttcac gagggcttct cctccatcac ctaccagcac gacttggctc tgctgcgcct 1380
gcaggaaagc aaaaccaaca gttgcgcgat cctgtcacct cacgttcagc ctgtgtgtct 1440
acccagcggc gcggccccac cctctgagac agtgctctgc gaggtggccg gctggggtca 1500
ccagttcgag ggggctgaag aatactccac cttcctgcag gaggcacagg ttccctttat 1560
cgccctggat cgctgctcca actctaacgt gcacggagac gccattctcc ctgggatgct 1620
ttgcgctggc ttcttggagg gaggcaccga tgcctgccag ggtgactccg ggggccctct 1680
ggtgtgtgag gaaggaactg cagaacatca gctcaccctg cgcggagtca tcagctgggg 1740
ctccggctgt ggtgaccgca acaagcccgg agtctacaca gacgtggcca actacctggc 1800
ttggatccag aagcatattg cttcataact aaccaggctt tatccttccc tccttgtgtg 1860
ctccttggga tgggacgatg aatgtggcat gctgggtcac agtgaagcta gtgccccgac 1920
actgggggca cagaaactca ataaagtgct ttgaaaacgt t                     1961

<210> 3
<211> 2128
<212> DNA
<213> Rattus norvegicus

<400> 3
caggaaccca tctcggtact ctgcttccac cagccttgcc ctgctcacga gggttcgacg 60
gcgctgttct tctgggcttt ctgtgaagtc tgtgctcctc aggcccagga gggagcttaa 120
ccaatctcca cctctgaggt ttctgagacc tttgcccaca tctattgatc cttactctgg 180
ggcaggcagc tgggccattg gcggacgcca tgacggctct gttgttcctg gggtctctgc 240
tgatgagtct ggacttgaca ctttcggcgc caccgtggaa gtccaaggag ttcaaggacg 300
gagctggcga tccctctgtg gttctcactg tggacgggaa gctctgccac tttccctttc 360
agtaccaccg tcgcctgtac cacaaatgca tccacaaagg acagccaggc tccaggccct 420
ggtgtgctac cacccccaac tttgacgagg accagcaatg gggatactgc ttggagccca 480
agaaagtgaa agaccattgc agcaaacaca gcccctgcca caaaggaggg acgtgtgtca 540
acacccccaa cggcccgcac tgtctctgcc ctgaacacct caccgggaaa cattgccaga 600
gagagaaatg ctttgagtct cagctcctca agttcttcca tgagaatgag atatggttta 660
gaactgggcc aggaggtgtg gccaggtgcc agtgcaaagg tcctcaggct gtttgcaagc 720
tgctgaccag tcaggtttgc agggtcaatc cgtgccttaa tggaggcacc tgcctcctcg 780
tggaggacca ccgactgtgc cactgccctg caggctatgc cggacctttt tgcgacttag 840
accttaaggc gacttgctac gaagacaggg gtctcagcta ccggggccag gctaaaacta 900
ctctgtcggg tgcaccatgt cagcggtggg cctcggaggc cacctaccgg aacatgactg 960
agacgcaagc tctaagctgg ggcctgggcc accacgcatt ctgccggaac ccagataatg 1020
acacacgtcc atggtgctac gtctggagtg gcgacaggct gagctgggac tactgcgacc 1080
tggaacagtg ccagatgcca acgctcacat ctccggtttc ccctgagagt cacgacatgc 1140
tgaagccccg gcctcccata ttgcagatgc ctcagttccc gtctctgtcc gatgcactag 1200
acaactcgac ccgtaatcag aatgttgtgt ccaggaccag tacggtggtc tgcggacaga 1260
ggtttcgcaa gcgactgtcc tcgctcaggc gcgtggtggg cggactagtg gctctgcctg 1320
gatcgcatcc ctacatcgct gcactgtact ggggcgacag cttctgcgca ggcagtctca 1380
tcgacccctg ctgggtgctg accgctgctc actgcttgca gaaacggcca gcgcccgagg 1440
aactgacagt ggtacttggt caagatcgcc ataaccagag ctgcgagagg tgccagactc 1500
tggctgtgca ctcctaccgc cttcacgagg gcttctcttc caaaacctac cagcatgatt 1560
tggctctgct gcgcctgcgg gggaggaaaa acagctgcgc gatcttgtcg cctcatgtcc 1620
agccggtgtg tctgcccagc agcgcggccc caccctctga gacagtgctc tgcgaggtgg 1680
ccggctgggg tcatcagttc gagggggctg aagaatacgc cacctttctg caggaggcac 1740
aggtaccctt catctccctg gatcgctgct ccagctctaa cgtgcacgga gacgccatcc 1800
tgcctgggat gctttgtgct ggcttcttgg agggaggcgc cgatgcctgt cagggtgact 1860
ccgggggtcc tctggtatgt gatgaaggag ttacagagcg tcagctcacc ctgcgaggag 1920
tcatcagctg gggctccggc tgtggtgacc ggaacaagcc cggggtctac actgacgtgg 1980
ccaattacct ggattggatc caggagcata ctgctttcta agtaaccagg gtcggtcctt 2040
gcgaagctag tggctgggcc ccagggacac agaaactcaa taaagtgctt tgaaaacgtt 2100
aaaaaaaaaa aaaaaaaaaa aaaaaaaa                                    2128

<210> 4
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 4
caaaggaggg acatgtatca acac                                        24

<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 5
ctggcaatgt ttcccagtga                                             20

<210> 6
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Probe

<400> 6
cccaatgggc cacactgtct ctgc                                        24

<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 7
gcatgggaca gagatggtgc                                             20

<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 8
gcacacaagg agggaaggat                                             20

<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 9
cgtcccatcc caaggagcac                                             20

<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 10
gtgacccagc atgccacatt                                             20

<210> 11
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 11
gggccaccac gcattct                                                17

<210> 12
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 12
cgccactcca gacgtagca                                              19

<210> 13
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Probe

<400> 13
ccggaaccca gataatgaca cacgtcc                                     27

<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 14
ggcaatgttt cccggtgagg                                             20

<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 15
cgccttaagg tctaagtcgc                                             20

<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 16
cgtcagtgta gaccccgggc                                             20

<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 17
cccggtgagg tgttcagggc                                             20

<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 18
tcgcaaggac cgaccctggt                                             20

<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 19
ggcccagcca ctagcttcgc                                             20
