                         SEQUENCE LISTING

<110>  Demopulos, G.A.
       Gaitanaris, G.
            
 
<120>  TREATMENT OF ADDICTION AND IMPULSE-CONTROL DISORDERS USING PDE7 INHIBITORS

<130>  NE.1.0133.PCT

<150>  US 61/411,431
<151>  2010-11-08

<150>  US 61/411,437
<151>  2010-11-08

<150>  US 61/482,944
<151>  2011-05-05


<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  1739
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (157)..(1527)

<400>  1
ggggatcact gttggaaggc agctgcttga ggtccaaggc agtcagtgtc ccctctcttt       60

tgcctcggga cagctggtat ttatcagact cctaagaagt tttccttgct ccctagtaga      120

agagagagat tatgcagcgg gcttttgatt gatcca atg gga att aca ttg atc        174
                                        Met Gly Ile Thr Leu Ile           
                                        1               5                 

tgg tgt ctg gcc ttg gtt ctt atc aag tgg atc acc tct aag agg cgt        222
Trp Cys Leu Ala Leu Val Leu Ile Lys Trp Ile Thr Ser Lys Arg Arg           
            10                  15                  20                    

gga gct att tcc tat gac agt tct gat cag act gca tta tac att cgt        270
Gly Ala Ile Ser Tyr Asp Ser Ser Asp Gln Thr Ala Leu Tyr Ile Arg           
        25                  30                  35                        

atg cta gga gat gta cgt gta agg agc cga gca gga ttt gaa tca gaa        318
Met Leu Gly Asp Val Arg Val Arg Ser Arg Ala Gly Phe Glu Ser Glu           
    40                  45                  50                            

aga aga ggt tct cac cca tat att gat ttt cgt att ttc cac tct caa        366
Arg Arg Gly Ser His Pro Tyr Ile Asp Phe Arg Ile Phe His Ser Gln           
55                  60                  65                  70            

tct gaa att gaa gtg tct gtc tct gca agg aat atc aga agg cta cta        414
Ser Glu Ile Glu Val Ser Val Ser Ala Arg Asn Ile Arg Arg Leu Leu           
                75                  80                  85                

agt ttc cag cga tat ctt aga tct tca cgc ttt ttt cgt ggt act gcg        462
Ser Phe Gln Arg Tyr Leu Arg Ser Ser Arg Phe Phe Arg Gly Thr Ala           
            90                  95                  100                   

gtt tca aat tcc cta aac att tta gat gat gat tat aat gga caa gcc        510
Val Ser Asn Ser Leu Asn Ile Leu Asp Asp Asp Tyr Asn Gly Gln Ala           
        105                 110                 115                       

aag tgt atg ctg gaa aaa gtt gga aat tgg aat ttt gat atc ttt cta        558
Lys Cys Met Leu Glu Lys Val Gly Asn Trp Asn Phe Asp Ile Phe Leu           
    120                 125                 130                           

ttt gat aga cta aca aat gga aat agt cta gta agc tta acc ttt cat        606
Phe Asp Arg Leu Thr Asn Gly Asn Ser Leu Val Ser Leu Thr Phe His           
135                 140                 145                 150           

tta ttt agt ctt cat gga tta att gag tac ttc cat tta gat atg atg        654
Leu Phe Ser Leu His Gly Leu Ile Glu Tyr Phe His Leu Asp Met Met           
                155                 160                 165               

aaa ctt cgt aga ttt tta gtt atg att caa gaa gat tac cac agt caa        702
Lys Leu Arg Arg Phe Leu Val Met Ile Gln Glu Asp Tyr His Ser Gln           
            170                 175                 180                   

aat cct tac cat aac gca gtc cac gct gcg gat gtt act cag gcc atg        750
Asn Pro Tyr His Asn Ala Val His Ala Ala Asp Val Thr Gln Ala Met           
        185                 190                 195                       

cac tgt tac tta aag gaa cct aag ctt gcc aat tct gta act cct tgg        798
His Cys Tyr Leu Lys Glu Pro Lys Leu Ala Asn Ser Val Thr Pro Trp           
    200                 205                 210                           

gat atc ttg ctg agc tta att gca gct gcc act cat gat ctg gat cat        846
Asp Ile Leu Leu Ser Leu Ile Ala Ala Ala Thr His Asp Leu Asp His           
215                 220                 225                 230           

cca ggt gtt aat caa cct ttc ctt att aaa act aac cat tac ttg gca        894
Pro Gly Val Asn Gln Pro Phe Leu Ile Lys Thr Asn His Tyr Leu Ala           
                235                 240                 245               

act tta tac aag aat acc tca gta ctg gaa aat cac cac tgg aga tct        942
Thr Leu Tyr Lys Asn Thr Ser Val Leu Glu Asn His His Trp Arg Ser           
            250                 255                 260                   

gca gtg ggc tta ttg aga gaa tca ggc tta ttc tca cat ctg cca tta        990
Ala Val Gly Leu Leu Arg Glu Ser Gly Leu Phe Ser His Leu Pro Leu           
        265                 270                 275                       

gaa agc agg caa caa atg gag aca cag ata ggt gct ctg ata cta gcc       1038
Glu Ser Arg Gln Gln Met Glu Thr Gln Ile Gly Ala Leu Ile Leu Ala           
    280                 285                 290                           

aca gac atc agt cgc cag aat gag tat ctg tct ttg ttt agg tcc cat       1086
Thr Asp Ile Ser Arg Gln Asn Glu Tyr Leu Ser Leu Phe Arg Ser His           
295                 300                 305                 310           

ttg gat aga ggt gat tta tgc cta gaa gac acc aga cac aga cat ttg       1134
Leu Asp Arg Gly Asp Leu Cys Leu Glu Asp Thr Arg His Arg His Leu           
                315                 320                 325               

gtt tta cag atg gct ttg aaa tgt gct gat att tgt aac cca tgt cgg       1182
Val Leu Gln Met Ala Leu Lys Cys Ala Asp Ile Cys Asn Pro Cys Arg           
            330                 335                 340                   

acg tgg gaa tta agc aag cag tgg agt gaa aaa gta acg gag gaa ttc       1230
Thr Trp Glu Leu Ser Lys Gln Trp Ser Glu Lys Val Thr Glu Glu Phe           
        345                 350                 355                       

ttc cat caa gga gat ata gaa aaa aaa tat cat ttg ggt gtg agt cca       1278
Phe His Gln Gly Asp Ile Glu Lys Lys Tyr His Leu Gly Val Ser Pro           
    360                 365                 370                           

ctt tgc gat cgt cac act gaa tct att gcc aac atc cag att ggt ttt       1326
Leu Cys Asp Arg His Thr Glu Ser Ile Ala Asn Ile Gln Ile Gly Phe           
375                 380                 385                 390           

atg act tac cta gtg gag cct tta ttt aca gaa tgg gcc agg ttt tcc       1374
Met Thr Tyr Leu Val Glu Pro Leu Phe Thr Glu Trp Ala Arg Phe Ser           
                395                 400                 405               

aat aca agg cta tcc cag aca atg ctt gga cac gtg ggg ctg aat aaa       1422
Asn Thr Arg Leu Ser Gln Thr Met Leu Gly His Val Gly Leu Asn Lys           
            410                 415                 420                   

gcc agc tgg aag gga ctg cag aga gaa cag tcg agc agt gag gac act       1470
Ala Ser Trp Lys Gly Leu Gln Arg Glu Gln Ser Ser Ser Glu Asp Thr           
        425                 430                 435                       

gat gct gca ttt gag ttg aac tca cag tta tta cct cag gaa aat cgg       1518
Asp Ala Ala Phe Glu Leu Asn Ser Gln Leu Leu Pro Gln Glu Asn Arg           
    440                 445                 450                           

tta tca taa cccccagaac cagtgggaca aactgcctcc tggaggtttt               1567
Leu Ser                                                                   
455                                                                       

tagaaatgtg aaatggggtc ttgaggtgag agaacttaac tcttgactgc caaggtttcc     1627

aagtgagtga tgccagccag cattatttat ttccaagatt tcctctgttg gatcatttga     1687

acccacttgt taattgcaag acccgaacat acagcaatat gaatttggct tt             1739


<210>  2
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Ile Thr Leu Ile Trp Cys Leu Ala Leu Val Leu Ile Lys Trp 
1               5                   10                  15      


Ile Thr Ser Lys Arg Arg Gly Ala Ile Ser Tyr Asp Ser Ser Asp Gln 
            20                  25                  30          


Thr Ala Leu Tyr Ile Arg Met Leu Gly Asp Val Arg Val Arg Ser Arg 
        35                  40                  45              


Ala Gly Phe Glu Ser Glu Arg Arg Gly Ser His Pro Tyr Ile Asp Phe 
    50                  55                  60                  


Arg Ile Phe His Ser Gln Ser Glu Ile Glu Val Ser Val Ser Ala Arg 
65                  70                  75                  80  


Asn Ile Arg Arg Leu Leu Ser Phe Gln Arg Tyr Leu Arg Ser Ser Arg 
                85                  90                  95      


Phe Phe Arg Gly Thr Ala Val Ser Asn Ser Leu Asn Ile Leu Asp Asp 
            100                 105                 110         


Asp Tyr Asn Gly Gln Ala Lys Cys Met Leu Glu Lys Val Gly Asn Trp 
        115                 120                 125             


Asn Phe Asp Ile Phe Leu Phe Asp Arg Leu Thr Asn Gly Asn Ser Leu 
    130                 135                 140                 


Val Ser Leu Thr Phe His Leu Phe Ser Leu His Gly Leu Ile Glu Tyr 
145                 150                 155                 160 


Phe His Leu Asp Met Met Lys Leu Arg Arg Phe Leu Val Met Ile Gln 
                165                 170                 175     


Glu Asp Tyr His Ser Gln Asn Pro Tyr His Asn Ala Val His Ala Ala 
            180                 185                 190         


Asp Val Thr Gln Ala Met His Cys Tyr Leu Lys Glu Pro Lys Leu Ala 
        195                 200                 205             


Asn Ser Val Thr Pro Trp Asp Ile Leu Leu Ser Leu Ile Ala Ala Ala 
    210                 215                 220                 


Thr His Asp Leu Asp His Pro Gly Val Asn Gln Pro Phe Leu Ile Lys 
225                 230                 235                 240 


Thr Asn His Tyr Leu Ala Thr Leu Tyr Lys Asn Thr Ser Val Leu Glu 
                245                 250                 255     


Asn His His Trp Arg Ser Ala Val Gly Leu Leu Arg Glu Ser Gly Leu 
            260                 265                 270         


Phe Ser His Leu Pro Leu Glu Ser Arg Gln Gln Met Glu Thr Gln Ile 
        275                 280                 285             


Gly Ala Leu Ile Leu Ala Thr Asp Ile Ser Arg Gln Asn Glu Tyr Leu 
    290                 295                 300                 


Ser Leu Phe Arg Ser His Leu Asp Arg Gly Asp Leu Cys Leu Glu Asp 
305                 310                 315                 320 


Thr Arg His Arg His Leu Val Leu Gln Met Ala Leu Lys Cys Ala Asp 
                325                 330                 335     


Ile Cys Asn Pro Cys Arg Thr Trp Glu Leu Ser Lys Gln Trp Ser Glu 
            340                 345                 350         


Lys Val Thr Glu Glu Phe Phe His Gln Gly Asp Ile Glu Lys Lys Tyr 
        355                 360                 365             


His Leu Gly Val Ser Pro Leu Cys Asp Arg His Thr Glu Ser Ile Ala 
    370                 375                 380                 


Asn Ile Gln Ile Gly Phe Met Thr Tyr Leu Val Glu Pro Leu Phe Thr 
385                 390                 395                 400 


Glu Trp Ala Arg Phe Ser Asn Thr Arg Leu Ser Gln Thr Met Leu Gly 
                405                 410                 415     


His Val Gly Leu Asn Lys Ala Ser Trp Lys Gly Leu Gln Arg Glu Gln 
            420                 425                 430         


Ser Ser Ser Glu Asp Thr Asp Ala Ala Phe Glu Leu Asn Ser Gln Leu 
        435                 440                 445             


Leu Pro Gln Glu Asn Arg Leu Ser 
    450                 455     


<210>  3
<211>  2990
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1275)

<400>  3
atg gaa gtg tgt tac cag ctg ccg gta ctg ccc ctg gac agg ccg gtc         48
Met Glu Val Cys Tyr Gln Leu Pro Val Leu Pro Leu Asp Arg Pro Val           
1               5                   10                  15                

ccc cag cac gtc ctc agc cgc cga gga gcc atc agc ttc agc tcc agc         96
Pro Gln His Val Leu Ser Arg Arg Gly Ala Ile Ser Phe Ser Ser Ser           
            20                  25                  30                    

tcc gct ctc ttc ggc tgc ccc aat ccc cgg cag ctc tct cag agg cgt        144
Ser Ala Leu Phe Gly Cys Pro Asn Pro Arg Gln Leu Ser Gln Arg Arg           
        35                  40                  45                        

gga gct att tcc tat gac agt tct gat cag act gca tta tac att cgt        192
Gly Ala Ile Ser Tyr Asp Ser Ser Asp Gln Thr Ala Leu Tyr Ile Arg           
    50                  55                  60                            

atg cta gga gat gta cgt gta agg agc cga gca gga ttt gaa tca gaa        240
Met Leu Gly Asp Val Arg Val Arg Ser Arg Ala Gly Phe Glu Ser Glu           
65                  70                  75                  80            

aga aga ggt tct cac cca tat att gat ttt cgt att ttc cac tct caa        288
Arg Arg Gly Ser His Pro Tyr Ile Asp Phe Arg Ile Phe His Ser Gln           
                85                  90                  95                

tct gaa att gaa gtg tct gtc tct gca agg aat atc aga agg cta cta        336
Ser Glu Ile Glu Val Ser Val Ser Ala Arg Asn Ile Arg Arg Leu Leu           
            100                 105                 110                   

agt ttc cag cga tat ctt aga tct tca cgc ttt ttt cgt ggt act gcg        384
Ser Phe Gln Arg Tyr Leu Arg Ser Ser Arg Phe Phe Arg Gly Thr Ala           
        115                 120                 125                       

gtt tca aat tcc cta aac att tta gat gat gat tat aat gga caa gcc        432
Val Ser Asn Ser Leu Asn Ile Leu Asp Asp Asp Tyr Asn Gly Gln Ala           
    130                 135                 140                           

aag tgt atg ctg gaa aaa gtt gga aat tgg aat ttt gat atc ttt cta        480
Lys Cys Met Leu Glu Lys Val Gly Asn Trp Asn Phe Asp Ile Phe Leu           
145                 150                 155                 160           

ttt gat aga cta aca aat gga aat agt cta gta agc tta acc ttt cat        528
Phe Asp Arg Leu Thr Asn Gly Asn Ser Leu Val Ser Leu Thr Phe His           
                165                 170                 175               

tta ttt agt ctt cat gga tta att gag tac ttc cat tta gat atg atg        576
Leu Phe Ser Leu His Gly Leu Ile Glu Tyr Phe His Leu Asp Met Met           
            180                 185                 190                   

aaa ctt cgt aga ttt tta gtt atg att caa gaa gat tac cac agt caa        624
Lys Leu Arg Arg Phe Leu Val Met Ile Gln Glu Asp Tyr His Ser Gln           
        195                 200                 205                       

aat cct tac cat aac gca gtc cac gct gcg gat gtt act cag gcc atg        672
Asn Pro Tyr His Asn Ala Val His Ala Ala Asp Val Thr Gln Ala Met           
    210                 215                 220                           

cac tgt tac tta aag gaa cct aag ctt gcc aat tct gta act cct tgg        720
His Cys Tyr Leu Lys Glu Pro Lys Leu Ala Asn Ser Val Thr Pro Trp           
225                 230                 235                 240           

gat atc ttg ctg agc tta att gca gct gcc act cat gat ctg gat cat        768
Asp Ile Leu Leu Ser Leu Ile Ala Ala Ala Thr His Asp Leu Asp His           
                245                 250                 255               

cca ggt gtt aat caa cct ttc ctt att aaa act aac cat tac ttg gca        816
Pro Gly Val Asn Gln Pro Phe Leu Ile Lys Thr Asn His Tyr Leu Ala           
            260                 265                 270                   

act tta tac aag aat acc tca gta ctg gaa aat cac cac tgg aga tct        864
Thr Leu Tyr Lys Asn Thr Ser Val Leu Glu Asn His His Trp Arg Ser           
        275                 280                 285                       

gca gtg ggc tta ttg aga gaa tca ggc tta ttc tca cat ctg cca tta        912
Ala Val Gly Leu Leu Arg Glu Ser Gly Leu Phe Ser His Leu Pro Leu           
    290                 295                 300                           

gaa agc agg caa caa atg gag aca cag ata ggt gct ctg ata cta gcc        960
Glu Ser Arg Gln Gln Met Glu Thr Gln Ile Gly Ala Leu Ile Leu Ala           
305                 310                 315                 320           

aca gac atc agt cgc cag aat gag tat ctg tct ttg ttt agg tcc cat       1008
Thr Asp Ile Ser Arg Gln Asn Glu Tyr Leu Ser Leu Phe Arg Ser His           
                325                 330                 335               

ttg gat aga ggt gat tta tgc cta gaa gac acc aga cac aga cat ttg       1056
Leu Asp Arg Gly Asp Leu Cys Leu Glu Asp Thr Arg His Arg His Leu           
            340                 345                 350                   

gtt tta cag atg gct ttg aaa tgt gct gat att tgt aac cca tgt cgg       1104
Val Leu Gln Met Ala Leu Lys Cys Ala Asp Ile Cys Asn Pro Cys Arg           
        355                 360                 365                       

acg tgg gaa tta agc aag cag tgg agt gaa aaa gta acg gag gaa ttc       1152
Thr Trp Glu Leu Ser Lys Gln Trp Ser Glu Lys Val Thr Glu Glu Phe           
    370                 375                 380                           

ttc cat caa gga gat ata gaa aaa aaa tat cat ttg ggt gtg agt cca       1200
Phe His Gln Gly Asp Ile Glu Lys Lys Tyr His Leu Gly Val Ser Pro           
385                 390                 395                 400           

ctt tgc gat cgt cac act gaa tct att gcc aac atc cag att ggt aac       1248
Leu Cys Asp Arg His Thr Glu Ser Ile Ala Asn Ile Gln Ile Gly Asn           
                405                 410                 415               

tat aca tat tta gat ata gct ggt tag aaaaatgcca ctgtttttat             1295
Tyr Thr Tyr Leu Asp Ile Ala Gly                                           
            420                                                           

caagaaggga aatatatttg aaatataaaa tattaaaatt atgctcattt ctatttttaa     1355

aaataattta agaaatttta cccttgtttt cccttgttat ggctcttcta attctcattt     1415

aattttagga tgtaaaaagt atatttttgc agaacaggca gcagcaataa cttgtttctg     1475

ttcttatgta aataagaatc cattattcgc tcatgtggaa gcttcttttg catcatttgg     1535

gactgccatt taaaaaagga taggtaaaca aagaaatgac aaaaataaaa taaataaaat     1595

aaaaatggat aggtggtgac ccactgagcc tgatcataat acgaagacca gcttctgcca     1655

ctgcctttcc agactcttac cactgcctgt tgattaaatc taactcttca acatcctaga     1715

caggccctta taatcttgct tcaaatgctg tgcagccatc ttgcctcaac ttccctctca     1775

tttgcctaca gcatctcggg acgcttctgt gtttcccaag tatacgctgt tctttcgctc     1835

tttgtgcttc gccagtgctt tccatgtgcc tcgtagagtt atttttcttg aagaggcagc     1895

tcaaatgtca ccttctccag aagctgctct ccacttgctt taggcagagt cagtcacttt     1955

tcttctagat tccaaagtgc ctgatccact tggttgtgga ttcctggagc ctagcaccac     2015

accagaagca cgaggccctt gagaactgtg tgttgagtga actaataact gtattataga     2075

aagcataatg aaaatgtcct gtgactgaag tatgtgtagc ttgttgcagg agtcacagga     2135

aagttgacta ggattgagtg tgttgggctt tgggtataaa ggagggggat tctacggggg     2195

cagtagctca acaaggaata gagggaggag tgtaattttg gtagctggtg ttgaataggg     2255

cctttgagaa tcagactgaa cacagtgaaa tatgtgccca aagttcagaa agatgaagtt     2315

tccagaaact aagaaggtag cacaatatgt ggcatcatac tcagaaagga agaccatgcc     2375

atggggccag aaattcagaa acgtaattct tacattgtga ttgcaatgga tactcatgaa     2435

agaaagtggg tagtggccga tttgccttca gagtgacagg tagagaaggg aagagcgtgt     2495

agaactgtgg ccatacttta ggagtgtgag ggatgctgaa tctcccagag agctcacact     2555

ggccaggaat gctgagagta gcagatgctt ttcttttggg aggatagtaa aacaatttag     2615

aaccagatat gctttgtctt gattctcaag tagaataatc ttcaaatgca aaagaataca     2675

ttagaaatgg acaaaagtgg ccaggagcgg tagctcatac ttgtaaccca gcactttggg     2735

aagccgaggc gggctgatcg cttgaggtca ggagttcgag accagcctgg ccaaaatagt     2795

gaaactcacg tttctactaa aaatacaaaa attagctggg tgtgatggcc acttgggagg     2855

ctgagatagg agaatcgctt gaacctggga ggcagaggtt gcagtgagcc aatatcgtgc     2915

cactgcattc cagcctgggt gacagaatga aactccatca ctccatctca aaaaaaaaaa     2975

aaaaaaaaaa aaaaa                                                      2990


<210>  4
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Val Cys Tyr Gln Leu Pro Val Leu Pro Leu Asp Arg Pro Val 
1               5                   10                  15      


Pro Gln His Val Leu Ser Arg Arg Gly Ala Ile Ser Phe Ser Ser Ser 
            20                  25                  30          


Ser Ala Leu Phe Gly Cys Pro Asn Pro Arg Gln Leu Ser Gln Arg Arg 
        35                  40                  45              


Gly Ala Ile Ser Tyr Asp Ser Ser Asp Gln Thr Ala Leu Tyr Ile Arg 
    50                  55                  60                  


Met Leu Gly Asp Val Arg Val Arg Ser Arg Ala Gly Phe Glu Ser Glu 
65                  70                  75                  80  


Arg Arg Gly Ser His Pro Tyr Ile Asp Phe Arg Ile Phe His Ser Gln 
                85                  90                  95      


Ser Glu Ile Glu Val Ser Val Ser Ala Arg Asn Ile Arg Arg Leu Leu 
            100                 105                 110         


Ser Phe Gln Arg Tyr Leu Arg Ser Ser Arg Phe Phe Arg Gly Thr Ala 
        115                 120                 125             


Val Ser Asn Ser Leu Asn Ile Leu Asp Asp Asp Tyr Asn Gly Gln Ala 
    130                 135                 140                 


Lys Cys Met Leu Glu Lys Val Gly Asn Trp Asn Phe Asp Ile Phe Leu 
145                 150                 155                 160 


Phe Asp Arg Leu Thr Asn Gly Asn Ser Leu Val Ser Leu Thr Phe His 
                165                 170                 175     


Leu Phe Ser Leu His Gly Leu Ile Glu Tyr Phe His Leu Asp Met Met 
            180                 185                 190         


Lys Leu Arg Arg Phe Leu Val Met Ile Gln Glu Asp Tyr His Ser Gln 
        195                 200                 205             


Asn Pro Tyr His Asn Ala Val His Ala Ala Asp Val Thr Gln Ala Met 
    210                 215                 220                 


His Cys Tyr Leu Lys Glu Pro Lys Leu Ala Asn Ser Val Thr Pro Trp 
225                 230                 235                 240 


Asp Ile Leu Leu Ser Leu Ile Ala Ala Ala Thr His Asp Leu Asp His 
                245                 250                 255     


Pro Gly Val Asn Gln Pro Phe Leu Ile Lys Thr Asn His Tyr Leu Ala 
            260                 265                 270         


Thr Leu Tyr Lys Asn Thr Ser Val Leu Glu Asn His His Trp Arg Ser 
        275                 280                 285             


Ala Val Gly Leu Leu Arg Glu Ser Gly Leu Phe Ser His Leu Pro Leu 
    290                 295                 300                 


Glu Ser Arg Gln Gln Met Glu Thr Gln Ile Gly Ala Leu Ile Leu Ala 
305                 310                 315                 320 


Thr Asp Ile Ser Arg Gln Asn Glu Tyr Leu Ser Leu Phe Arg Ser His 
                325                 330                 335     


Leu Asp Arg Gly Asp Leu Cys Leu Glu Asp Thr Arg His Arg His Leu 
            340                 345                 350         


Val Leu Gln Met Ala Leu Lys Cys Ala Asp Ile Cys Asn Pro Cys Arg 
        355                 360                 365             


Thr Trp Glu Leu Ser Lys Gln Trp Ser Glu Lys Val Thr Glu Glu Phe 
    370                 375                 380                 


Phe His Gln Gly Asp Ile Glu Lys Lys Tyr His Leu Gly Val Ser Pro 
385                 390                 395                 400 


Leu Cys Asp Arg His Thr Glu Ser Ile Ala Asn Ile Gln Ile Gly Asn 
                405                 410                 415     


Tyr Thr Tyr Leu Asp Ile Ala Gly 
            420                 


<210>  5
<211>  2100
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (304)..(1656)

<400>  5
cagtcagttg gtctgggcac tgcagcaggc tcggctctgt cccagcactt gtctgggaga       60

aaagtggtgt tactcaccca gggagagtct ctctttctac cttccttctt tctcgatctc      120

cttgtgtgct tttgtgtttc tttatttctt ttcctttttt ttcttttttt ttttttgtta      180

cttaattata ttcctaatcc tggatgaagt tgctggattc tgcagcacaa gtcttcatga      240

acaagcagca ccgctcagag atttcacggc attcaaaggt cacagaactg ccactatggt      300

taa atg tct tgt tta atg gtt gag agg tgt ggc gaa atc ttg ttt gag        348
    Met Ser Cys Leu Met Val Glu Arg Cys Gly Glu Ile Leu Phe Glu           
    1               5                   10                  15            

aac ccc gat cag aat gcc aaa tgt gtt tgc atg ctg gga gat ata cga        396
Asn Pro Asp Gln Asn Ala Lys Cys Val Cys Met Leu Gly Asp Ile Arg           
                20                  25                  30                

cta agg ggt cag acg ggg gtt cgt gct gaa cgc cgt ggc tcc tac cca        444
Leu Arg Gly Gln Thr Gly Val Arg Ala Glu Arg Arg Gly Ser Tyr Pro           
            35                  40                  45                    

ttc att gac ttc cgc cta ctt aac agt aca aca tac tca ggg gag att        492
Phe Ile Asp Phe Arg Leu Leu Asn Ser Thr Thr Tyr Ser Gly Glu Ile           
        50                  55                  60                        

ggc acc aag aaa aag gtg aaa aga cta tta agc ttt caa aga tac ttc        540
Gly Thr Lys Lys Lys Val Lys Arg Leu Leu Ser Phe Gln Arg Tyr Phe           
    65                  70                  75                            

cat gca tca agg ctg ctt cgt gga att ata cca caa gcc cct ctg cac        588
His Ala Ser Arg Leu Leu Arg Gly Ile Ile Pro Gln Ala Pro Leu His           
80                  85                  90                  95            

ctg ctg gat gaa gac tac ctt gga caa gca agg cat atg ctc tcc aaa        636
Leu Leu Asp Glu Asp Tyr Leu Gly Gln Ala Arg His Met Leu Ser Lys           
                100                 105                 110               

gtg gga atg tgg gat ttt gac att ttc ttg ttt gat cgc ttg aca aat        684
Val Gly Met Trp Asp Phe Asp Ile Phe Leu Phe Asp Arg Leu Thr Asn           
            115                 120                 125                   

gga aac agc ctg gta aca ctg ttg tgc cac ctc ttc aat acc cat gga        732
Gly Asn Ser Leu Val Thr Leu Leu Cys His Leu Phe Asn Thr His Gly           
        130                 135                 140                       

ctc att cac cat ttc aag tta gat atg gtg acc tta cac cga ttt tta        780
Leu Ile His His Phe Lys Leu Asp Met Val Thr Leu His Arg Phe Leu           
    145                 150                 155                           

gtc atg gtt caa gaa gat tac cac agc caa aac ccg tat cac aat gct        828
Val Met Val Gln Glu Asp Tyr His Ser Gln Asn Pro Tyr His Asn Ala           
160                 165                 170                 175           

gtt cac gca gcc gac gtc acc cag gcc atg cac tgc tac ctg aaa gag        876
Val His Ala Ala Asp Val Thr Gln Ala Met His Cys Tyr Leu Lys Glu           
                180                 185                 190               

cca aag ctt gcc agc ttc ctc acg cct ctg gac atc atg ctt gga ctg        924
Pro Lys Leu Ala Ser Phe Leu Thr Pro Leu Asp Ile Met Leu Gly Leu           
            195                 200                 205                   

ctg gct gca gca gca cac gat gtg gac cac cca ggg gtg aac cag cca        972
Leu Ala Ala Ala Ala His Asp Val Asp His Pro Gly Val Asn Gln Pro           
        210                 215                 220                       

ttt ttg ata aaa act aac cac cat ctt gca aac cta tat cag aat atg       1020
Phe Leu Ile Lys Thr Asn His His Leu Ala Asn Leu Tyr Gln Asn Met           
    225                 230                 235                           

tct gtg ctg gag aat cat cac tgg cga tct aca att ggc atg ctt cga       1068
Ser Val Leu Glu Asn His His Trp Arg Ser Thr Ile Gly Met Leu Arg           
240                 245                 250                 255           

gaa tca agg ctt ctt gct cat ttg cca aag gaa atg aca cag gat att       1116
Glu Ser Arg Leu Leu Ala His Leu Pro Lys Glu Met Thr Gln Asp Ile           
                260                 265                 270               

gaa cag cag ctg ggc tcc ttg atc ttg gca aca gac atc aac agg cag       1164
Glu Gln Gln Leu Gly Ser Leu Ile Leu Ala Thr Asp Ile Asn Arg Gln           
            275                 280                 285                   

aat gaa ttt ttg acc aga ttg aaa gct cac ctc cac aat aaa gac tta       1212
Asn Glu Phe Leu Thr Arg Leu Lys Ala His Leu His Asn Lys Asp Leu           
        290                 295                 300                       

aga ctg gag gat gca cag gac agg cac ttt atg ctt cag atc gcc ttg       1260
Arg Leu Glu Asp Ala Gln Asp Arg His Phe Met Leu Gln Ile Ala Leu           
    305                 310                 315                           

aag tgt gct gac att tgc aat cct tgt aga atc tgg gag atg agc aag       1308
Lys Cys Ala Asp Ile Cys Asn Pro Cys Arg Ile Trp Glu Met Ser Lys           
320                 325                 330                 335           

cag tgg agt gaa agg gtc tgt gaa gaa ttc tac agg caa ggt gaa ctt       1356
Gln Trp Ser Glu Arg Val Cys Glu Glu Phe Tyr Arg Gln Gly Glu Leu           
                340                 345                 350               

gaa cag aaa ttt gaa ctg gaa atc agt cct ctt tgt aat caa cag aaa       1404
Glu Gln Lys Phe Glu Leu Glu Ile Ser Pro Leu Cys Asn Gln Gln Lys           
            355                 360                 365                   

gat tcc atc cct agt ata caa att ggt ttc atg agc tac atc gtg gag       1452
Asp Ser Ile Pro Ser Ile Gln Ile Gly Phe Met Ser Tyr Ile Val Glu           
        370                 375                 380                       

ccg ctc ttc cgg gaa tgg gcc cat ttc acg ggt aac agc acc ctg tcg       1500
Pro Leu Phe Arg Glu Trp Ala His Phe Thr Gly Asn Ser Thr Leu Ser           
    385                 390                 395                           

gag aac atg ctg ggc cac ctc gca cac aac aag gcc cag tgg aag agc       1548
Glu Asn Met Leu Gly His Leu Ala His Asn Lys Ala Gln Trp Lys Ser           
400                 405                 410                 415           

ctg ttg ccc agg cag cac aga agc agg ggc agc agt ggc agc ggg cct       1596
Leu Leu Pro Arg Gln His Arg Ser Arg Gly Ser Ser Gly Ser Gly Pro           
                420                 425                 430               

gac cac gac cac gca ggc caa ggg act gag agc gag gag cag gaa ggc       1644
Asp His Asp His Ala Gly Gln Gly Thr Glu Ser Glu Glu Gln Glu Gly           
            435                 440                 445                   

gac agc ccc tag gggccggccc aacttagacg cggctctcct ccggcagggc           1696
Asp Ser Pro                                                               
        450                                                               

ccccagaggg cagaagcagc gtggaggggc cctcacgcag cagcccagcc actttctgag     1756

tgttgtcctg gggctctttg gaacgccatc ttcctcccac ttacctgcct cccctccttt     1816

tcgcaaatgt acagaagcca tttgtcacct cagcattcgc tgccgaaatg agcaactcca     1876

ttcagtaacg tgggagctga tcccacgggc aggctctccc tgctccagga gaagactagg     1936

aggaagaatg aggtgctcct gccgtgtccg ccttgttccg ggtcgcactg gaacaggcag     1996

caattcctaa gtccggagcg tttgagcgtt tgctatctga ctgctgatct gcgtgacaga     2056

aacaccagca tatttgcaac gccaaggata ttggtcttaa gtgc                      2100


<210>  6
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Cys Leu Met Val Glu Arg Cys Gly Glu Ile Leu Phe Glu Asn 
1               5                   10                  15      


Pro Asp Gln Asn Ala Lys Cys Val Cys Met Leu Gly Asp Ile Arg Leu 
            20                  25                  30          


Arg Gly Gln Thr Gly Val Arg Ala Glu Arg Arg Gly Ser Tyr Pro Phe 
        35                  40                  45              


Ile Asp Phe Arg Leu Leu Asn Ser Thr Thr Tyr Ser Gly Glu Ile Gly 
    50                  55                  60                  


Thr Lys Lys Lys Val Lys Arg Leu Leu Ser Phe Gln Arg Tyr Phe His 
65                  70                  75                  80  


Ala Ser Arg Leu Leu Arg Gly Ile Ile Pro Gln Ala Pro Leu His Leu 
                85                  90                  95      


Leu Asp Glu Asp Tyr Leu Gly Gln Ala Arg His Met Leu Ser Lys Val 
            100                 105                 110         


Gly Met Trp Asp Phe Asp Ile Phe Leu Phe Asp Arg Leu Thr Asn Gly 
        115                 120                 125             


Asn Ser Leu Val Thr Leu Leu Cys His Leu Phe Asn Thr His Gly Leu 
    130                 135                 140                 


Ile His His Phe Lys Leu Asp Met Val Thr Leu His Arg Phe Leu Val 
145                 150                 155                 160 


Met Val Gln Glu Asp Tyr His Ser Gln Asn Pro Tyr His Asn Ala Val 
                165                 170                 175     


His Ala Ala Asp Val Thr Gln Ala Met His Cys Tyr Leu Lys Glu Pro 
            180                 185                 190         


Lys Leu Ala Ser Phe Leu Thr Pro Leu Asp Ile Met Leu Gly Leu Leu 
        195                 200                 205             


Ala Ala Ala Ala His Asp Val Asp His Pro Gly Val Asn Gln Pro Phe 
    210                 215                 220                 


Leu Ile Lys Thr Asn His His Leu Ala Asn Leu Tyr Gln Asn Met Ser 
225                 230                 235                 240 


Val Leu Glu Asn His His Trp Arg Ser Thr Ile Gly Met Leu Arg Glu 
                245                 250                 255     


Ser Arg Leu Leu Ala His Leu Pro Lys Glu Met Thr Gln Asp Ile Glu 
            260                 265                 270         


Gln Gln Leu Gly Ser Leu Ile Leu Ala Thr Asp Ile Asn Arg Gln Asn 
        275                 280                 285             


Glu Phe Leu Thr Arg Leu Lys Ala His Leu His Asn Lys Asp Leu Arg 
    290                 295                 300                 


Leu Glu Asp Ala Gln Asp Arg His Phe Met Leu Gln Ile Ala Leu Lys 
305                 310                 315                 320 


Cys Ala Asp Ile Cys Asn Pro Cys Arg Ile Trp Glu Met Ser Lys Gln 
                325                 330                 335     


Trp Ser Glu Arg Val Cys Glu Glu Phe Tyr Arg Gln Gly Glu Leu Glu 
            340                 345                 350         


Gln Lys Phe Glu Leu Glu Ile Ser Pro Leu Cys Asn Gln Gln Lys Asp 
        355                 360                 365             


Ser Ile Pro Ser Ile Gln Ile Gly Phe Met Ser Tyr Ile Val Glu Pro 
    370                 375                 380                 


Leu Phe Arg Glu Trp Ala His Phe Thr Gly Asn Ser Thr Leu Ser Glu 
385                 390                 395                 400 


Asn Met Leu Gly His Leu Ala His Asn Lys Ala Gln Trp Lys Ser Leu 
                405                 410                 415     


Leu Pro Arg Gln His Arg Ser Arg Gly Ser Ser Gly Ser Gly Pro Asp 
            420                 425                 430         


His Asp His Ala Gly Gln Gly Thr Glu Ser Glu Glu Gln Glu Gly Asp 
        435                 440                 445             


Ser Pro 
    450 


