                              Sequence Listing

<110> Genentech, Inc.
      F. Hoffmann-La Roche AG
      
<120> SUBCUTANEOUSLY ADMINISTERED ANTI-IL-6 RECEPTOR ANTIBODY

<130> P4494R1-WO

<141> 2011-11-07

<150> US 61/411,015
<151> 2010-11-08

<150> US 61/542,615
<151> 2011-10-03

<160> 8

<210> 1
<211> 214
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized.

<400> 1
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
                  20                  25                  30

 Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
                 110                 115                 120

 Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu
                 125                 130                 135

 Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val
                 140                 145                 150

 Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu
                 155                 160                 165

 Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr
                 170                 175                 180

 Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu
                 185                 190                 195

 Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn
                 200                 205                 210

 Arg Gly Glu Cys
                

<210> 2
<211> 448
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized. The first amino acid residue is predominantly pyroglutamic acid (pE).

<400> 2
 Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser
   1               5                  10                  15

 Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr
                  20                  25                  30

 Ser Asp His Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Arg Gly
                  35                  40                  45

 Leu Glu Trp Ile Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Thr Tyr
                  50                  55                  60

 Asn Pro Ser Leu Lys Ser Arg Val Thr Met Leu Arg Asp Thr Ser
                  65                  70                  75

 Lys Asn Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Ser Leu Ala Arg Thr Thr Ala
                  95                 100                 105

 Met Asp Tyr Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Ala
                 110                 115                 120

 Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
                 125                 130                 135

 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
                 140                 145                 150

 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu
                 155                 160                 165

 Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
                 170                 175                 180

 Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu
                 185                 190                 195

 Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn
                 200                 205                 210

 Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
                 215                 220                 225

 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
                 230                 235                 240

 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                 245                 250                 255

 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
                 260                 265                 270

 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
                 275                 280                 285

 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
                 290                 295                 300

 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
                 305                 310                 315

 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                 320                 325                 330

 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
                 335                 340                 345

 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
                 350                 355                 360

 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                 365                 370                 375

 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
                 380                 385                 390

 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
                 395                 400                 405

 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
                 410                 415                 420

 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
                 425                 430                 435

 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 440                 445            

<210> 3
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized.

<400> 3
 Arg Ala Ser Gln Asp Ile Ser Ser Tyr Leu Asn
                   5                  10    

<210> 4
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized.

<400> 4
 Tyr Thr Ser Arg Leu His Ser
                   5        

<210> 5
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized.

<400> 5
 Gln Gln Gly Asn Thr Leu Pro Tyr Thr
                   5                

<210> 6
<211> 6
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized.

<400> 6
 Ser Asp His Ala Trp Ser
                   5    

<210> 7
<211> 16
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized.

<400> 7
 Tyr Ile Ser Tyr Ser Gly Ile Thr Thr Tyr Asn Pro Ser Leu Lys
   1               5                  10                  15

 Ser
    

<210> 8
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized.

<400> 8
 Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr
                   5                  10

