                         SEQUENCE LISTING

<110>  Kymab Limited
 
<120>  CELLS & VERTEBRATES FOR ENHANCED SOMATIC HYPERMUTATION AND CLASS 
       SWITCH RECOMBINATION

<130>  25077.13WO

<150>  GB1018786.2
<151>  2010-11-08

<150>  GB1020483.2
<151>  2010-12-03

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  597
<212>  DNA
<213>  Homo sapiens

<400>  1
atggacagcc tcttgatgaa ccggaggaag tttctttacc aattcaaaaa tgtccgctgg       60

gctaagggtc ggcgtgagac ctacctgtgc tacgtagtga agaggcgtga cagtgctaca      120

tccttttcac tggactttgg ttatcttcgc aataagaacg gctgccacgt ggaattgctc      180

ttcctccgct acatctcgga ctgggaccta gaccctggcc gctgctaccg cgtcacctgg      240

ttcacctcct ggagcccctg ctacgactgt gcccgacatg tggccgactt tctgcgaggg      300

aaccccaacc tcagtctgag gatcttcacc gcgcgcctct acttctgtga ggaccgcaag      360

gctgagcccg aggggctgcg gcggctgcac cgcgccgggg tgcaaatagc catcatgacc      420

ttcaaagatt atttttactg ctggaatact tttgtagaaa accacgaaag aactttcaaa      480

gcctgggaag ggctgcatga aaattcagtt cgtctctcca gacagcttcg gcgcatcctt      540

ttgcccctgt atgaggttga tgacttacga gacgcatttc gtactttggg actttga         597


<210>  2
<211>  597
<212>  DNA
<213>  Pan troglodytes

<400>  2
atggacagcc tcttgatgaa ccggaagaag tttctttacc aattcaaaaa tgtccgctgg       60

gctaagggtc ggcgtgagac ctacctgtgc tacgtagtga agaggcggga cagtgctaca      120

tccttttcac tggactttgg ttatcttcgc aataagaacg gctgccacgt ggaattgctc      180

ttcctccgct acatctcgga ctgggaccta gaccctggcc gctgctaccg cgtcacctgg      240

ttcacctcct ggagcccctg ctacgactgt gcccgacatg tggccgactt tctgcgaggg      300

aaccccaacc tcagtctgag gatcttcacc gcgcgcctct acttctgtga ggaccgcaag      360

gctgagcccg aggggctgcg gcggctgcac cgcgccgggg tgcaaatagc catcatgacc      420

ttcaaagatt atttttactg ctggaatact tttgtagaaa accatgaaag gactttcaaa      480

gcctgggaag ggctgcatga aaattcagtt cgtctctcca gacagcttcg gcgcatcctt      540

ttgcccctgt atgaggttga tgacttacga gacgcatttc gtactttggg actttga         597


<210>  3
<211>  600
<212>  DNA
<213>  Bos Taurus

<400>  3
atggacagcc tcttgaagaa gcagagacag tttctttacc agttcaaaaa cgtgcgctgg       60

gctaagggcc gccatgagac ctacttgtgc tacgtggtga agcggcggga cagtcccacc      120

tccttctcac tggacttcgg gcaccttcga aacaaggccg gatgccacgt ggagttgctc      180

ttccttcgct acatctctga ctgggatctg gaccctgggc ggtgctaccg cgtcacctgg      240

ttcacgtctt ggagcccctg ctacgactgt gcgcggcacg tggccgactt cctgcggggg      300

taccccaacc tgagcctgcg gatcttcacg gcgcgcctct acttctgcga caaggagcgc      360

aaggccgagc cagaggggct gcggcggctg caccgcgctg gagtccagat cgccatcatg      420

acgttcaaag attattttta ttgctggaat acttttgtgg aaaatcatga aagaactttc      480

aaagcctggg agggactgca tgaaaattcg gttcgtctgt ctagacagct tcgacgcatc      540

cttttgccac tctacgaggt tgatgacttg cgggatgcat ttcgtacttt gggactttga      600


<210>  4
<211>  597
<212>  DNA
<213>  Canis lupus

<400>  4
atggacagcc tcctgatgaa gcagaggaag tttctttacc atttcaagaa tgtccgctgg       60

gcgaagggtc gccatgagac ttacttgtgc tacgtggtga agcggcggga tagtgccacc      120

tccttttctc tggactttgg tcaccttcga aacaagtcgg gctgccacgt ggagctgctc      180

ttcctccgct acatctccga ctgggacctg gaccccggcc ggtgctaccg cgtcacctgg      240

ttcacgtcct ggagcccctg ctacgactgc gcgcggcacg tggcggactt cctgcgcggg      300

taccccaacc tcagcctcag gatcttcgcc gcgcgcctct acttctgcga ggaccgcaag      360

gcggagcccg aggggctgcg gcggctgcac cgggcgggcg tccagatcgc catcatgacc      420

ttcaaggatt atttttattg ctggaatact tttgtggaaa atcgtgaaaa aactttcaaa      480

gcctgggagg ggttgcacga aaattccgtt cgactatcca gacagcttcg acgcattctt      540

ttgcccctgt atgaggttga tgacttacga gatgcatttc gtactttggg actttga         597


<210>  5
<211>  621
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  5
atgccgcaga cccgctcctc gccgctggtc ctccttttga tgaagcagaa gaagtttctt       60

tatcacttca agaatgtccg ctgggctaag ggccggcacg agacctacct gtgctacgtg      120

gtcaagcggc gggacagtgc cacctccttc tcactggact tcggctacct gcgcaacacg      180

aacggctgcc acgtggaatt gctcttcctc cgctacatct ccgactggga cctggacccc      240

ggccgctgct accgcgtcac ctggttcacc tcctggagcc cttgctacga ctgtgcccgg      300

cacgtggctg acttcctgag aggcaacccc aacctcactc tgaggatctt caccgcgcgc      360

ctctacttct gcgaggaccg caaggccgag cccgagggac tgcggcggct gcaccaagcg      420

ggcgtccagc tcggcatcat gaccttcaaa gattattttt actgctggaa tactttcgtg      480

gagaaccgtg agagaacgtt caaggcctgg gaaggcctgc atgaaaattc tgtccgcctg      540

tccagacagc tccggcgcat ccttctgccc ctttatgagg tcgatgacct acgagatgcg      600

tttcgtactt tgggactttg a                                                621


<210>  6
<211>  597
<212>  DNA
<213>  Rattus norvegicus

<400>  6
atggacagcc tcttgatgaa gcaaaagaag tttctttacc acttcaaaaa tgtccgctgg       60

gctaagggtc ggcacgagac ctacctgtgc tatgtggtga agaggagaga tagtgccacc      120

tccttctcac tggactttgg ccaccttcgc aacaagtcgg gctgccacgt ggaattgttg      180

ttcctacgct acatctcgga ctgggacctg gaccccggcc ggtgttaccg tgtcacctgg      240

ttcacttcct ggagcccctg ctacgactgt gcgcggcacg tggctgagtt tctgagatgg      300

aaccctaacc tcagcctgag gattttcacc gcgcgcctct acttctgcga agaccgcaag      360

gctgagcctg aggggctgcg gaggctgcac cgcgccggag tccagatcgg gatcatgacc      420

ttcaaagact atttttactg ctggaataca tttgtagaaa atcatgaaag aactttcaaa      480

gcctgggaag ggctgcatga aaactccgtc aggctaacca gacagcttcg gcgcatcctt      540

ttgcccttgt atgaagtcga tgacttgaga gatgcgtttc gtattttggg actttga         597


<210>  7
<211>  597
<212>  DNA
<213>  Mus musculus

<400>  7
atggacagcc ttctgatgaa gcaaaagaag tttctttacc atttcaaaaa tgtccgctgg       60

gccaagggac ggcatgagac ctacctctgc tacgtggtga agaggagaga tagtgccacc      120

tcctgctcac tggacttcgg ccaccttcgc aacaagtctg gctgccacgt ggaattgttg      180

ttcctacgct acatctcaga ctgggacctg gacccgggcc ggtgttaccg cgtcacctgg      240

ttcacctcct ggagcccgtg ctatgactgt gcccggcacg tggctgagtt tctgagatgg      300

aaccctaacc tcagcctgag gattttcacc gcgcgcctct acttctgtga agaccgcaag      360

gctgagcctg aggggctgcg gagactgcac cgcgctgggg tccagatcgg gatcatgacc      420

ttcaaagact atttttactg ctggaataca tttgtagaaa atcgtgaaag aactttcaaa      480

gcctgggaag ggctacatga aaattctgtc cggctaacca gacaacttcg gcgcatcctt      540

ttgcccttgt acgaagtcga tgacttgcga gatgcatttc gtatgttggg attttga         597


<210>  8
<211>  597
<212>  DNA
<213>  Gallus gallus

<400>  8
atggacagcc tcttgatgaa gaggaagctc ttcctctaca atttcaagaa cctgcgctgg       60

gccaaaggcc gtcgtgaaac ctacctctgt tatgttgtga agcgccgtga cagtgctaca      120

tcatgctccc tggactttgg atacctgcgt aacaagatgg gttgccatgt ggaggttctc      180

ttcctacgct acatctcagc ttgggacctg gacccaggcc gctgctaccg catcacatgg      240

ttcacctcct ggagcccctg ttatgactgt gcccgacatg tggctgactt ccttcgtgcc      300

tacccaaact tgaccctccg cattttcact gcccgcctct acttctgtga agatcgcaag      360

gctgagcctg aggggctgag acgcctgcac cgggctgggg cccaaatcgc catcatgact      420

ttcaaagatt tcttctactg ctggaacacg tttgtggaga acagggaaaa gacattcaaa      480

gcctgggaag ggctgcatga aaactctgtc catctgtcca ggaaactccg acggatcctt      540

ctgccactgt atgaagtaga tgatttacga gatgccttta aaactctggg actttga         597


<210>  9
<211>  606
<212>  DNA
<213>  Xenopus laevis

<400>  9
atgacgatgg acagcatgtt gttgaagcgc aacaagttca tctatcacta caagaacctg       60

cgctgggccc ggggtcggca cgagacctac ctgtgctaca tagtcaagcg gagatacagc      120

tcagtgtcct gcgcgttgga cttcgggtac ctgcggaacc gcaacggctg ccacgctgag      180

atgctcttcc tgcgctacct gtctatatgg gtgggtcacg acccccatag gaactaccgg      240

gtcacgtggt tcagctcctg gagcccctgc tatgactgtg ccaagcgcac cctcgagttc      300

ttaaaggggc accccaactt cagtctgcgc atcttcagcg ccaggctcta tttctgcgag      360

gagcgcaacg cggagccgga ggggctgcgg aaactgcaga aagcgggggt gcgactgtct      420

gtcatgagct acaaagatta tttctactgc tggaacacct ttgtggagac ccgggagagc      480

ggctttgaag cctgggatgg attacacgag aactcggtca gactggcccg gaagctgcgg      540

cgcatcttgc agccgccgta cgacatggag gatctgagag aagtgtttgt tctacttggg      600

ctttaa                                                                 606


<210>  10
<211>  630
<212>  DNA
<213>  Ictalurus punctatus

<400>  10
atgagcaagc tggacagtgt gctgctgact cagaggaagt ttatttacca ctataagaat       60

gtgcgctggg ctcgtgggag gaacgagacc tacctctgtt ttgtggtcaa gaaacgcaac      120

agtcccgact cgctctcctt cgacttcgga cacctgcgca atcgttctgg ctgccatgtg      180

gagcttctct tcctgagcta tcttggggta ctgtgcccag gtttcttggg ttccggtgtg      240

gatggtgtca gggtggctta tgccatcacc tggttctgtt cctggtcacc ctgttcaaac      300

tgtgcccatc gcctttctcg cttcatgtct cagatgccca acctgcggct gcgcatcttc      360

gtctcgcgcc tctacttctg tgacgaggag gacagtcaag agagagaggg actccgttgc      420

ttgcagaggg caggtgtgca agtgacagtc atgacctata aagatttttt ctactgttgg      480

caaacctttg tggctcaaaa tcagaaggct ttcaaggctt gggacgacct tcaccagaac      540

tctatccgac tgtctcggaa actacagcga atcctgcagc ctagtgagtc tgaagacctg      600

agggatggct tcgctctgct gggcctttaa                                       630


<210>  11
<211>  633
<212>  DNA
<213>  Danio rerio

<400>  11
atgatctgca agctggacag tgtgctcatg acccagaaga aattcatctt ccactataag       60

aatgtgcgct gggctcgagg gagacacgaa acctaccttt gttttgtagt aaagcgacgc      120

atcggccctg attccctctc ttttgacttt ggacacctgc gcaatcgctc cggatgccat      180

gtagagcttc tctttctgcg tcacttgggt gcgttgtgtc cgggcctgag cgcttccagt      240

gtggacggtg caagattgtg ttactcagtg acctggttct gctcctggtc tccctgctct      300

aaatgcgctc aacagctcgc ccacttcctg tcacagacgc ccaatctgag gctgaggatc      360

tttgtgtcac gcctgtactt ctgtgatgaa gaggacagcg tggagagaga aggtctgcga      420

cacctgaaga gggcaggagt tcagatctcg gtcatgactt ataaagactt tttctactgc      480

tggcaaacgt ttgttgcaag gagggagcgg agttttaaag cctgggatgg acttcatgaa      540

aactctgtcc ggcttgttcg aaaactcaat cggattctgc agccttgcga aactgaggat      600

ctgagggatg tttttgctct tcttgggtta tga                                   633


<210>  12
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr 
        35                  40                  45              


Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Thr Leu Gly Leu 
        195             


<210>  13
<211>  198
<212>  PRT
<213>  Pan troglodytes

<400>  13

Met Asp Ser Leu Leu Met Asn Arg Lys Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr 
        35                  40                  45              


Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Thr Leu Gly Leu 
        195             


<210>  14
<211>  199
<212>  PRT
<213>  Bos Taurus

<400>  14

Met Asp Ser Leu Leu Lys Lys Gln Arg Gln Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Pro Thr Ser Phe Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ala Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Tyr Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Asp Lys Glu Arg Lys Ala Glu Pro Glu Gly Leu Arg 
        115                 120                 125             


Arg Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp 
    130                 135                 140                 


Tyr Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe 
145                 150                 155                 160 


Lys Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln 
                165                 170                 175     


Leu Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp 
            180                 185                 190         


Ala Phe Arg Thr Leu Gly Leu 
        195                 


<210>  15
<211>  198
<212>  PRT
<213>  Canis lupus

<400>  15

Met Asp Ser Leu Leu Met Lys Gln Arg Lys Phe Leu Tyr His Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ser Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Tyr Pro Asn Leu Ser Leu Arg Ile Phe Ala Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn Arg Glu Lys Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Thr Leu Gly Leu 
        195             


<210>  16
<211>  206
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  16

Met Pro Gln Thr Arg Ser Ser Pro Leu Val Leu Leu Leu Met Lys Gln 
1               5                   10                  15      


Lys Lys Phe Leu Tyr His Phe Lys Asn Val Arg Trp Ala Lys Gly Arg 
            20                  25                  30          


His Glu Thr Tyr Leu Cys Tyr Val Val Lys Arg Arg Asp Ser Ala Thr 
        35                  40                  45              


Ser Phe Ser Leu Asp Phe Gly Tyr Leu Arg Asn Thr Asn Gly Cys His 
    50                  55                  60                  


Val Glu Leu Leu Phe Leu Arg Tyr Ile Ser Asp Trp Asp Leu Asp Pro 
65                  70                  75                  80  


Gly Arg Cys Tyr Arg Val Thr Trp Phe Thr Ser Trp Ser Pro Cys Tyr 
                85                  90                  95      


Asp Cys Ala Arg His Val Ala Asp Phe Leu Arg Gly Asn Pro Asn Leu 
            100                 105                 110         


Thr Leu Arg Ile Phe Thr Ala Arg Leu Tyr Phe Cys Glu Asp Arg Lys 
        115                 120                 125             


Ala Glu Pro Glu Gly Leu Arg Arg Leu His Gln Ala Gly Val Gln Leu 
    130                 135                 140                 


Gly Ile Met Thr Phe Lys Asp Tyr Phe Tyr Cys Trp Asn Thr Phe Val 
145                 150                 155                 160 


Glu Asn Arg Glu Arg Thr Phe Lys Ala Trp Glu Gly Leu His Glu Asn 
                165                 170                 175     


Ser Val Arg Leu Ser Arg Gln Leu Arg Arg Ile Leu Leu Pro Leu Tyr 
            180                 185                 190         


Glu Val Asp Asp Leu Arg Asp Ala Phe Arg Thr Leu Gly Leu 
        195                 200                 205     


<210>  17
<211>  198
<212>  PRT
<213>  Rattus norvegicus

<400>  17

Met Asp Ser Leu Leu Met Lys Gln Lys Lys Phe Leu Tyr His Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ser Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Glu 
                85                  90                  95      


Phe Leu Arg Trp Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Gly Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Thr Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Ile Leu Gly Leu 
        195             


<210>  18
<211>  198
<212>  PRT
<213>  Mus musculus

<400>  18

Met Asp Ser Leu Leu Met Lys Gln Lys Lys Phe Leu Tyr His Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Cys Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ser Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Glu 
                85                  90                  95      


Phe Leu Arg Trp Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Gly Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn Arg Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Thr Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Met Leu Gly Phe 
        195             


<210>  19
<211>  198
<212>  PRT
<213>  Gallus gallus

<400>  19

Met Asp Ser Leu Leu Met Lys Arg Lys Leu Phe Leu Tyr Asn Phe Lys 
1               5                   10                  15      


Asn Leu Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Cys Ser Leu Asp Phe Gly Tyr 
        35                  40                  45              


Leu Arg Asn Lys Met Gly Cys His Val Glu Val Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Ala Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Ile Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Ala Tyr Pro Asn Leu Thr Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Ala Gln Ile Ala Ile Met Thr Phe Lys Asp Phe 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn Arg Glu Lys Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val His Leu Ser Arg Lys Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Lys Thr Leu Gly Leu 
        195             


<210>  20
<211>  201
<212>  PRT
<213>  Xenopus laevis

<400>  20

Met Thr Met Asp Ser Met Leu Leu Lys Arg Asn Lys Phe Ile Tyr His 
1               5                   10                  15      


Tyr Lys Asn Leu Arg Trp Ala Arg Gly Arg His Glu Thr Tyr Leu Cys 
            20                  25                  30          


Tyr Ile Val Lys Arg Arg Tyr Ser Ser Val Ser Cys Ala Leu Asp Phe 
        35                  40                  45              


Gly Tyr Leu Arg Asn Arg Asn Gly Cys His Ala Glu Met Leu Phe Leu 
    50                  55                  60                  


Arg Tyr Leu Ser Ile Trp Val Gly His Asp Pro His Arg Asn Tyr Arg 
65                  70                  75                  80  


Val Thr Trp Phe Ser Ser Trp Ser Pro Cys Tyr Asp Cys Ala Lys Arg 
                85                  90                  95      


Thr Leu Glu Phe Leu Lys Gly His Pro Asn Phe Ser Leu Arg Ile Phe 
            100                 105                 110         


Ser Ala Arg Leu Tyr Phe Cys Glu Glu Arg Asn Ala Glu Pro Glu Gly 
        115                 120                 125             


Leu Arg Lys Leu Gln Lys Ala Gly Val Arg Leu Ser Val Met Ser Tyr 
    130                 135                 140                 


Lys Asp Tyr Phe Tyr Cys Trp Asn Thr Phe Val Glu Thr Arg Glu Ser 
145                 150                 155                 160 


Gly Phe Glu Ala Trp Asp Gly Leu His Glu Asn Ser Val Arg Leu Ala 
                165                 170                 175     


Arg Lys Leu Arg Arg Ile Leu Gln Pro Pro Tyr Asp Met Glu Asp Leu 
            180                 185                 190         


Arg Glu Val Phe Val Leu Leu Gly Leu 
        195                 200     


<210>  21
<211>  209
<212>  PRT
<213>  Ictalurus punctatus

<400>  21

Met Ser Lys Leu Asp Ser Val Leu Leu Thr Gln Arg Lys Phe Ile Tyr 
1               5                   10                  15      


His Tyr Lys Asn Val Arg Trp Ala Arg Gly Arg Asn Glu Thr Tyr Leu 
            20                  25                  30          


Cys Phe Val Val Lys Lys Arg Asn Ser Pro Asp Ser Leu Ser Phe Asp 
        35                  40                  45              


Phe Gly His Leu Arg Asn Arg Ser Gly Cys His Val Glu Leu Leu Phe 
    50                  55                  60                  


Leu Ser Tyr Leu Gly Val Leu Cys Pro Gly Phe Leu Gly Ser Gly Val 
65                  70                  75                  80  


Asp Gly Val Arg Val Ala Tyr Ala Ile Thr Trp Phe Cys Ser Trp Ser 
                85                  90                  95      


Pro Cys Ser Asn Cys Ala His Arg Leu Ser Arg Phe Met Ser Gln Met 
            100                 105                 110         


Pro Asn Leu Arg Leu Arg Ile Phe Val Ser Arg Leu Tyr Phe Cys Asp 
        115                 120                 125             


Glu Glu Asp Ser Gln Glu Arg Glu Gly Leu Arg Cys Leu Gln Arg Ala 
    130                 135                 140                 


Gly Val Gln Val Thr Val Met Thr Tyr Lys Asp Phe Phe Tyr Cys Trp 
145                 150                 155                 160 


Gln Thr Phe Val Ala Gln Asn Gln Lys Ala Phe Lys Ala Trp Asp Asp 
                165                 170                 175     


Leu His Gln Asn Ser Ile Arg Leu Ser Arg Lys Leu Gln Arg Ile Leu 
            180                 185                 190         


Gln Pro Ser Glu Ser Glu Asp Leu Arg Asp Gly Phe Ala Leu Leu Gly 
        195                 200                 205             


Leu 
    


<210>  22
<211>  210
<212>  PRT
<213>  Danio rerio

<400>  22

Met Ile Cys Lys Leu Asp Ser Val Leu Met Thr Gln Lys Lys Phe Ile 
1               5                   10                  15      


Phe His Tyr Lys Asn Val Arg Trp Ala Arg Gly Arg His Glu Thr Tyr 
            20                  25                  30          


Leu Cys Phe Val Val Lys Arg Arg Ile Gly Pro Asp Ser Leu Ser Phe 
        35                  40                  45              


Asp Phe Gly His Leu Arg Asn Arg Ser Gly Cys His Val Glu Leu Leu 
    50                  55                  60                  


Phe Leu Arg His Leu Gly Ala Leu Cys Pro Gly Leu Ser Ala Ser Ser 
65                  70                  75                  80  


Val Asp Gly Ala Arg Leu Cys Tyr Ser Val Thr Trp Phe Cys Ser Trp 
                85                  90                  95      


Ser Pro Cys Ser Lys Cys Ala Gln Gln Leu Ala His Phe Leu Ser Gln 
            100                 105                 110         


Thr Pro Asn Leu Arg Leu Arg Ile Phe Val Ser Arg Leu Tyr Phe Cys 
        115                 120                 125             


Asp Glu Glu Asp Ser Val Glu Arg Glu Gly Leu Arg His Leu Lys Arg 
    130                 135                 140                 


Ala Gly Val Gln Ile Ser Val Met Thr Tyr Lys Asp Phe Phe Tyr Cys 
145                 150                 155                 160 


Trp Gln Thr Phe Val Ala Arg Arg Glu Arg Ser Phe Lys Ala Trp Asp 
                165                 170                 175     


Gly Leu His Glu Asn Ser Val Arg Leu Val Arg Lys Leu Asn Arg Ile 
            180                 185                 190         


Leu Gln Pro Cys Glu Thr Glu Asp Leu Arg Asp Val Phe Ala Leu Leu 
        195                 200                 205             


Gly Leu 
    210 


<210>  23
<211>  18372
<212>  DNA
<213>  Mus musculus

<400>  23
caagagctag ggacgcatcc aaaagaaccg gcaaccgggc ccaacagacg ttcattttcc       60

tgtttgttac atcatccacg gtaagcaagg acagcgacag ctcaagtctt caccagaaga      120

tgaaggtatc aacaaaacac agtaagggat ggaagtctga tacgtggtct aatgtgggca      180

gcttttgaag acgttgggca aaagtagccc gcagcacagc aagcgcaagg ccaatttgta      240

ctacatatgg aatctttctt gaaaccaaac aaagaacaat caagaaaaag gaagaaagga      300

tggaagggag ggagggaggg aaagagacag gaagcaaaca catcgggaca ggcgactttg      360

gcttccagtt atcttgaaca ggctaattca cagaaacaga aggtaggtta gaggtcgcta      420

gggtctgggg agtaagggac agctagtgac tgttatgtag gtgtatttat ttactgattg      480

attgactgat gcaatgaaag ttttagggta gggtctggag agatggctca gtgtctaaga      540

gcacatattc tgtagaggac tctggttcag ttcccagcac ccacaccagg cagcccacaa      600

ctgcctgtac caccagagaa cataacacac cagtcctcca ggcacacaca cacacacaca      660

cacacacaca cacacacaca cacacacaca cacacgcgcg cgcgcgcaca cacatgcatg      720

cacgcacgca cacacacaca cacattcttt aaggtttttt tgtttgtttt ggttttttgt      780

tgtctttctt tttgctttat gttttgtttg tttgtttatt tgtttgtttt tgagaccggc      840

tctatgtcct ggaattttcc atgtagacga ggctggcttg aactcacaga gatctgccta      900

cctatgcctc ctgaatggta gaattaaagg tgccactaca tttcgctcta aaattaaaat      960

ttaaaaataa aagttttagg gtgggtgaga tggttctgga agtaaaggca tttgccacca     1020

tcctggaacc ccggtgatgg aaggcaaaaa cggacttctg aaatttgtcc tctgacctcc     1080

acacacacac taaataaata taaaatttac aaattggttt aaattttaga aacaaacaga     1140

cctgctacgc aagcatgcat tctgagtact cagaaggcag aggcaagagg agccggaact     1200

cagccccctg acttgtctct gccccacaaa aggatgagaa aggtttaggt tccgagtgta     1260

accattgcca cagaatcctg cacttaagca aagaaacaag caagcaaaca aacaaacaga     1320

aacgccacag acaaacagaa gataagcatc aacaatacgc tgcttttctc cggtccaaaa     1380

ggccccagtt tgcctagaga gaccacgcag agcctgcgca gccacattca gagcaagccg     1440

cagtggtgtg gaacctctcc ttgaagacga gaaaacattt cctttcttta tttctatgtt     1500

ttgttttttg tttttgtttt ttagcagggt tccatgattg tcctggaact ggacacatag     1560

cccaggctag tctcaaactt ccaggaatcc tcctgcctta atcttcagaa tgctagaatt     1620

ctgatcgtgt acgactgcca tacttgtctt gggggcggga ttgcctgttc cgctgtctgt     1680

ctggcgacag ggtttcacta tgtagccctt ggttggtctg gaataccttt ccttctttct     1740

tccttaaaca tttgaaagat ttatttattt tatgtatgtg agtacaccgt agttgtcttc     1800

agaagcacca gaagagggca tcagatcaca ataaagatgg ttgtgagcca ccatgtggtt     1860

gctgggaatt gaacgcagga cctctggaag agcagtcagt gctcttaacc actgagccat     1920

ctctccagct cgcccactgg cttccttgct tgctttttct taagttttat ttatttattt     1980

atttatttat ttatttattt agttatttag ttatttattt agttatgtat attggtattt     2040

tttcgaagag gacatcagat ttcatcttag acggttgtga gccaccatgt gaatgcagag     2100

aattgaaccc aggtcctctg aaagaacagc cagtgctctt aaatactgaa ccatctctcc     2160

agcccctgct gctccctgtc cctctccctt ttaaagaaat ggtgtcagtc agaacaggca     2220

agatggttcc atggataaat gtccttgctg caaagcctga ctacttgagt tcaagcctca     2280

ggatctacat ggtggacaga gaggaccaag tcttgtaaat tgtcttctga catctacaca     2340

taagctctgg ccctcgtgcc tcatataccc ctccactgcc aagcacagca atatatatat     2400

aattttttaa aatgtaaaga aatcacaaca tctctgccaa tatccatcaa gtcggccctt     2460

tgggaggctg tgtacgtgtg tctcagtatg tcattccctg gacaattggc caaagtaggg     2520

caaaggtccg ggcctcatcc tgtgagacaa gttagaggga cttgtccacc caccacctgg     2580

gttcccttaa ccctgtaatg tcacggctgg tgctggttac tcccggtgcc ctgaaatttt     2640

tttcccagga attcattaat tcactagtga gggaaattgt gtctctgata gtgatgtgat     2700

aatgcagagg aaattaatta gaggaagaag gaggatgggg gctcattaac atttcagata     2760

tgatatccag ggaaggctaa actgccaggg agtaagccaa gtcctgaact atgagacttt     2820

gcacagagag atttcacagc aacaaaatag gggcaggggc atgtgctgtg tgcatgcaac     2880

gggatccagt ctctagctca agactggtct ggtctatata gaaagttcca gaccagccag     2940

aggagctaca taatgacacc ctatctaaaa aaaggaaggg aaggaaggaa ggaaggaagg     3000

aaggaagaaa ggaaggaagg agggagggag ggagggaggg agggagggag ggaggaaaga     3060

aggaaggaag gaaggaagga aggaaggaag gaaggaagga aggaaggaag gaaggaagag     3120

tataagaaag gaaggaagga agaaagcaaa ggatgttctt ccagatgatc agggttcaga     3180

tcccagcaac cacacatggt ggctttcaac cgcctgctgg tcctctgcaa tagaaataag     3240

tgctcttaat cactgggcca gctctccagg cctccagtaa ggtattttta atgaggaaaa     3300

agagttcttt tttaaaaaaa aaatactttt tgacacacac acacacacaa aattaaaata     3360

aatcactttt tggtgcaagc aactagtctt tctagctatc ttataatgtc attttaaaaa     3420

aagaaaaata tattagagaa ttaggaggct aaagttcact ctctggatgc tgtggtggtc     3480

aacccccatc tctactgagg cataaaactg agtgtaacaa acggaaggaa cagatactgt     3540

aagttcaaga agcacaagat gcatttaagg ccactttaag tcactatgac tgctatcatt     3600

cttgttatca caattttaaa attaggaagc atgcacagac cttaggtgtg atacctggga     3660

cccccccaca cacacacaca cacacactca cagagctcat tatcatgata ccaatgtgaa     3720

aagtgtccag tgctattgtc tcctgatctt tgttacctgt ggtacctggg ctggcttttt     3780

agaggaacag cctcgaagga agttggacat taagcatgag cagaactgcc ccccgccccc     3840

caatcattta atccgtgtgg ctctgcccac cacagccccg cccatcttta ctggacccaa     3900

cccaggaggc agatgttgga tacctggtgg tagtgatgct gtcgtggggg aggagcccac     3960

aagagcaagc tcagatttga atgccagggg ccagtgctct gtcacacaac agcactgaag     4020

cagccttgct tgaagcaagc ttcctttggc ctaagacttt gagggagtca agaaagtcac     4080

gctggagacc gatatggaca ggtaacaaga cagtctcatc tgcttgtgca tgtgctccag     4140

tagtgctggc tgcctgtctg gatggaggct ttgcctgtca gtgcgcgaat ttcctcgtct     4200

gcttgccacc ctctgctcag gtcttttggg ttttggacct aactctgacc acgaagttct     4260

tcccttcccc cggtttctct cttctctgtg ttgctagaga taggaagcct tgacttgtcc     4320

tgagatttgg gcagagctag agccggcttg tggtaataac agcgaagcct tagaggcccg     4380

cgccacaaag aggtcgtagc aactccttac taaaaacagt agtggttatt ttcacaatta     4440

tttggcaaat atccaacatc ttaagactcg catggggagt ctttacagga attatttagt     4500

tatagcaaga agatttgtac ttctcaaaaa aaaaaaaaaa aaaaaaaaaa ctaaacattt     4560

gagatgaatt gcttgcaact cattacaatg gtgtctattg aaggagagaa tttcattaag     4620

acaggcaatt tagtgttata gactcaactg ttagacactt ggtgacattt ttactgttta     4680

attcatctat gcagagattt cttagcttct tgaaagcttt tatatgcagc tcatgatgag     4740

ccattatcag aaatttctct cttgattttt acatttattg ccagtgtgtg agtcactatg     4800

cctaaagccc atacacttga gctcacttcc gtttggctat gaggtttaga atatggagtt     4860

aatatagcta atggtagcag ggtgttcttc agattccaga tttttccttt cttgtcttcc     4920

ttctttcttt ttgttaccct tctcctaccc cctcttcttc tccccctcct cctcttcctc     4980

cctcctcccc atctcttccc ctcctcttct ccctcctccc cctcctcttc cccttcccct     5040

cttccccctc ttcctcctct tcctcctcct tctcctgctc cccatctctt tccctcctct     5100

tctccctcct cctcctcctt ttgccccttc tcctcttccc cctcctcctc ttccttttcc     5160

ttctcctcct tctcctcctc cctctcctcc ccctttcctc ctcccactct ccctcacccc     5220

tatcagggac cacattgaag acctcacaca tgctagacaa gtaatctgcc acttaattac     5280

atcctgagcc ctcaaaaagc aaacagacag acagacagac agacaaacaa acaaacaaac     5340

aaacaaatgt tcacaggagg caggcagaca gcatgagctg cttctgggtt tatagtgaat     5400

tttgaaacca aatctgagat ctatgtcctg atggagaagg gtccgagaga aatgcatgag     5460

catggcaaaa tgcaaagcaa agacgaggct gagattcagg gagaagcaaa caagacagtg     5520

gagagacaca ggatggcacg gcatggactg gagcaagggc agcgggtaac tcaaggcagc     5580

cctgctacta ggctgggatt atttttaacc ccttgagtct ggtttgcatt gctggggaag     5640

cagctaaggt tctgcctcaa ggagcacagc tgtctcagca gctggcgatc tacaggtttg     5700

ggacaccacc tagcaaagtc ctccttaccg ggagggacat cccgaggaga gggagctgga     5760

aataggctcc tagctagagt tgaggggagt gctggatgga ggtgcccagt ccacaggtca     5820

ggactgtgca gctcctccca ccgtggctgg aatcttaaaa tagaaacagt ctattacatc     5880

ttcctgtggt tcagacacaa ctcttctatt tgagacacat cctttctaaa ctccaaggat     5940

acctttcctt cataatttca gcatccaccc ccaatacaca ctcataaata cacaaacaca     6000

cacacagagt aagagagaga gaaagagaga gataagcacg tatgtacact tgctacccac     6060

agtatgtagg aaaagttctc tagggctgtg tgtacggctc tgtggcacag cactcactag     6120

caggtacaag actccatgtt caacccactg aaaaagattc tctacttttc ccatctaggt     6180

aacacaggaa gtttagttaa atagaaaggg aatttattgc taagagatga agtttaagct     6240

gtttaaaact ggctggatta gagagatacc tgtgcttatt attataacat gctgagttta     6300

cctgtactgt ggtggtgatg atgataatga tgctgtgtca tcacatagcc cccgtggctt     6360

agaattctcc atgaaagtca ggctggcttc cattacagaa agatccacct gcctctgccc     6420

cccttcgccc ccaagttctg gatttaaagg tgtgcacacc atgcccagct tctaaagggt     6480

ttttataatt tagtgatgaa tgtagacatg gaggtactat gatcgttatc atggtaaatt     6540

actatttcaa aataaagcta tgatcattag aggccaagac aggaggacca tgagttcgag     6600

gccagctgca gcaacataga gatttccaga ctagcatgga tcccgcagca tgagcatgtc     6660

cccaaaacaa ttttgttttt ccaaaagtca gggactgtca cgtgtgttga actatcatta     6720

aagcatgagc tgtgaacgtg tgaacatgca ttcaatgata gtatatggtt atttatagtg     6780

gctctaacca ctgcagcacc aaagcggaac atatccaaat ttcaatcagc acataaatga     6840

ataaacaaaa catgttctac ccatacaata gaatattgct cggcaggaat aaggagccaa     6900

cttctgatat ttgggtgaat ataaaattta ctatgttccg tgagagcagt tacacaggaa     6960

ggaggaaacg tgatttatat gaaattatag aaagttagaa ataatttaca tttacagaga     7020

gcaggtcggc ggttgcctgg gtaagaggag aaagaacagc caatagcgac atagaagctt     7080

taagaagcct agaaatgtct cctctgatgg ccctggcagt ctgggctgcg gacctgccgg     7140

cattcacgga gctgtagatt ttaagcgagt ggagctcact atgtaaattg tatctcaaca     7200

acaacaaaag tgaaaaacgg tttcaattct cttgcatcaa aaccgtattc aaattcctaa     7260

ctagctctta aaaaaaaaat cattgcactt ccatccatca ccactgtgtg gcggtgctgt     7320

gtcgacaagt gagcgacaca gttgtttatc atccgtttta tctcctggct catgtccacc     7380

gctttaacag gaactgtaat tttttttttt ttttaagaaa cgtgagggct gggaatatgg     7440

ttctgtggga acagcgcttg ccatgaaagc aaaaggacct gagttgaggg gtccaaaagc     7500

agacacctgt aattcccgtg cttctaaggc aacataagag gtggagaaag gagaacccca     7560

ggaagcttat gagccagtta gcccagggcg cacagcagag agcaagagat tctatctcaa     7620

acaagacaga agtcaaggac caacacccaa ggttgtactc tgctcgccac acgtatcctg     7680

tagtatgtgt tgcctctacc cccaccacat acacacacac gcacacactc cacaaagatt     7740

ttaaaaatta tttttaagtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg     7800

tcaatgcatg tgccctcaaa agtcagaggt gtcggatcct ggtggaactg gagtgacagg     7860

tggttgtgag ctgcctgatg gaagagcagt tcgtgctcat aactgctgag ccatctctct     7920

agtccccaga aaacctgtat ttttaaagaa agaaagaacg aacgagaaaa aaaaaacctc     7980

gggggctgga gatgtagctc tactagagaa cttgccagca tgcacaaagc cctgggttaa     8040

gtccccaaca agtaggtggg acaagcctgt tgtcccaaga ccaggggagt agaggaggca     8100

ggagagttct ccttgtcaaa ttccccacca gcctgagcta aatgagttct catctcaaaa     8160

caaacaataa aaataaataa ataaaataaa atcaacaaaa ctgacccagc aaaatccaaa     8220

aatgaaaacc caaagaccta agcaggggtg ggggttaggg gggcgtggtt tgtcagacgg     8280

ctcagcaggt aaaggcataa actgccaaac ctgatgtctt gagtttgatc cctcgagctc     8340

acatgatgga agcagagagc caacttccac aagttgccct ttgacctcca caggtatgtg     8400

tatgtcccta cacacatatc attcatacaa cgatagtaaa caaatgtgat tttttttaaa     8460

gacacagagg caactatttc ttatacttct gtttaatgaa gaatggatag atactatgta     8520

gcaacgtgat cgcaagtcga catgacctca tatgaccctg tgcttagaga gggaggaagg     8580

acgcccccag caaggcccat ctgcaacatt ccttttcctg gatagagaca ggacacccac     8640

agaatatggc tcttcaagga agagagtgac ctttcttttc gcaggagctc agtggctttg     8700

ataccctgtt gtcttccttc ctcgctgtgg ctcaagtgct ggaagtagag agtgactttc     8760

tatgttttcc tttgctttgt cttgtactga gtcagaccta gagcctcata catgataggc     8820

aactgctgag ctactgagct acgttcttgt ggtggagctc aggctgggct caaacttaca     8880

gcaacctccc tcccccagcc ttccccccac tcccccccgc caccccccca ccccccaccc     8940

ccgcactccc aagtgctgag gttacaggca caagcaacct aacctggccc ttgccatgtt     9000

ttataacttg cttttggaag acttctggtt ctgtgatgct actgggttag cggggagaca     9060

ggagggcaga aggttaaagg tgtctaagac catgtccaaa gcccagtagg aggattaggg     9120

agatggctgg gctggagaga tggctcagtg gttaagagca ctggctgtgt ttgcagggga     9180

ccagagttca attcccagca accacataat ggctcacaat catctacaat gggatctgac     9240

accctccttt gacatgcagg catgcatgta cacagagcag tcatacataa attatataaa     9300

taaatacatt aaaaaataaa aagtaataaa gggtaattac ctagtttgac tgttgcagcg     9360

aggggggagg ggaagaggaa agggaagagg gtgggcaggg aaggatttta aagtgagcat     9420

gtctcaggta tccagaaaag gaagcacgac tatgctttct ggtttaacct atataatgat     9480

aagatttaaa acatcatgat gatcaaagta ggcctgggga tgcagctcgg tgctgaagcg     9540

ctcagctacc ttgcctatgg ctgtaggtcc agccatcagc agctgcaaca ataataatca     9600

gagctgaagg aagactatgg tgacagagaa gccttgccct gactttcttc tccaactcac     9660

agccttctga tgaagcaaaa gaagtttctt taccatttca aaaatgtccg ctgggccaag     9720

ggacggcatg agacctacct ctgctacgtg gtgaagagga gagatagtgc cacctcctgc     9780

tcactggact tcggccacct tcgcaacaag gtgggggggg ggttgcgggg ttggggaggg     9840

ggtgggtggc agctgttgac actaaagcta tggctgcccc tggtgccaaa tgttgagggg     9900

accaaggcag gccgattgct gagtttgaga cagcctggtc tacagagaga gttttaggac     9960

tacacagaga aaccctgtct ggaaaaacaa acaaacaagc aaacaaagag tgaaataatg    10020

gtgcatgcct gtatttccac agtgctaggg ctgaaatgaa ggatctgcct tgccagacaa    10080

gccccgcccc tgagccctcc cctaaccgcc tctggcccct cagcccctca gccctttaat    10140

ccctcagctc tgggttcttt ctcaagcact ttcttgagtg agaaaaacaa attatatctt    10200

cagaattttt gaaaatcaat gaggaaaaaa ataggtaaaa tgacatcaac tcaactttat    10260

ttcccaaaca attttgttcc caaaagacca gagaggccaa tgaccgacca cctttaaccc    10320

aatgagtttc cttcagggac cagagagaag tctctgttgt ttgggtaatt agataatcct    10380

tcggctgcct gaaagaactg cgtttctaag agagttcacc aaattgcaga ttggcttcca    10440

tgggcttctc cttctctact tggagtcatg acacactgta tttatagaca gcttgatcaa    10500

gtggtacttt ctcttcgcac acaacaccag cttgatttac tgctaaggaa atagtgcaaa    10560

aaaagatgag taaaagaaaa actatcttca gtcttcgaca aacgattttc gcaataggag    10620

atgggcctat tacgattgca gttattacag tcactggcat cacatagcat gtacacacac    10680

gcgcgcgcgc gcgcgcacac acacacacac acacacacac acacacacac acacacacac    10740

accccttaat tgccttccac ttaaaacgcc agacgccaag tcagagacga aatctcttca    10800

ataagctttt tcctccctcc ttacaaatta ttctggcgcc acctagtggc caaggtgcag    10860

tttgcagttt tacaacgtgg cgtccaaaca ggcacttccg ggacacgaag gtaatccctg    10920

caaggtgtgt atcctttgtc ccatagatgt gcagctttcc tttacccaac aaagccagtg    10980

taataaagcc atttgactcc aacaagtgct atcttaataa gagaattatc tttatgctgg    11040

gagtgatggc acacaccttt aatcccaacc ctccagaggc agaggcagat ggatctctgt    11100

gagtttgagg actgcctggt ctacataatg agttccaggt caagccagtg cgacatcccc    11160

acaagcatcc caaatggcct gggtgggaga gcatgcaggt cacgtcacca gtgctctctg    11220

ctctttctcc agtctggctg ccacgtggaa ttgttgttcc tacgctacat ctcagactgg    11280

gacctggacc cgggccggtg ttaccgcgtc acctggttca cctcctggag cccgtgctat    11340

gactgtgccc ggcacgtggc tgagtttctg agatggaacc ctaacctcag cctgaggatt    11400

ttcaccgcgc gcctctactt ctgtgaagac cgcaaggctg agcctgaggg gctgcggaga    11460

ctgcaccgcg ctggggtcca gatcgggatc atgaccttca aaggtgagac ttgcacactg    11520

gagagagcgg tctgagttgc cactcagagt gagtgtcagc ggggaaactg ggggtggggt    11580

gctacttaaa gaccttcagt tcgtcctgga tatcaaaagt attactttat tttttgaggt    11640

aggatctcgc tatcccaggc tgaccttcaa cttgcaattc tccgacctct gccttctgag    11700

tggcggaatt acaagtatac atcaatctca gaattatcag aatttgagag atagaagttg    11760

gcagggctac aggtgcgctc agtggcagaa ctctggtcca gcatgtgcaa agccctgcat    11820

tccaccttta gcagtcaaat aataaattga ggagggagag gaggaggata gtggtcagag    11880

agatggttcc gtgggggccc ttgcctttgt accttaagtt taacccctaa aacactctga    11940

ctttctgacc ttcacctaca cacacacaca cacacacaca cacacacaca cacacacctc    12000

cttcttattt atctatttat ttttctttta agactatttt tactgctgga atacatttgt    12060

agaaaatcgt gaaagaactt tcaaagcctg ggaagggcta catgaaaatt ctgtccggct    12120

aaccagacaa cttcggcgca tccttttggt aagtctgcct gtctgtctgc ctgtctctct    12180

gtctgtctct gtctctctgt ctgtctctgt ctctctctct ctctctcata cacacacaca    12240

tacatacact cacacacaca cacacacacc tggagcctct tagttatttg tttgtattat    12300

gcattatttt atacaatgat tacttcaagg cacttacaac ccagttttct tttctgcttt    12360

acccaggaca gagcttccac ttagacgctt gcctcttgcc tcctcttcgc tcagtcttca    12420

taactctttc cttttgctaa cctcccctca ggtggggttc cttccagggc agaattcgcc    12480

ccttcttttt ttcctggtcc tcaagcaatt tactttcctc tggagccacc cacttcgttt    12540

agacactttc ctttccagag atcaaattta aagcccttca ctccgtttat atcatctctc    12600

tttctccaca gcccttgtac gaagtcgatg acttgcgaga tgcatttcgt atgttgggat    12660

tttgaaagca acctcctgga atgtcacacg tgatgaaatt tctctgaaga gactggatag    12720

aaaaacaacc cttcaactac atgtttttct tcttaagtac tcacttttat aagtgtaggg    12780

ggaaattata tgacttttta aaaaatactt gagctgcaca ggaccgccag agcaatgatg    12840

taactgagct tgctgtgcaa catcgccatc tactggggaa cagcagaact tccagacttt    12900

gggtcgtgaa tgatgctctt ttttttcaac agcatggaaa agcatatgga gacgaccaca    12960

cagtttgtta cacccaccct gtgttccttg attcatttga attctcaggg gtatcagtga    13020

cggattcttc tattctttcc ctctaaggct cactttcagg ggtccttttc tgacaaggtc    13080

acggggctgt cctacagtct ctgtctgagc aatcacaagc cattctctca aaagcattaa    13140

tactcaggca catgctgtat gttttcactg tccgtcgtgt ttttcacatt tgtatgtgaa    13200

agggcttggg gtgggatttg aagaatgcac gatcgcctct gggtgatttc aataaaggat    13260

cttaaaatgc agatgaggac tacgaagaaa tcactctgaa aatgagttca cgcctcaaga    13320

agcaaatccc ctggaaacac agactctttt tcatttttaa tgtcattagt ttactcacag    13380

tcttatcaag aagaagagtt caagggttca acccaatttt cagatcgcgt cccttaaaca    13440

tcagtaattc tgttaaaggg atcaaacatc cttatttctt aactaactgg tgccttgctg    13500

tagagaaagg agcaaagcgc ccagatccaa agtatatagt tatcatagcc aggaaccgct    13560

actcgttttc cattacaaat ggcaaattct tccccgggct ctcctcatag tgcctgagac    13620

ggaccacgga ggtgatgaac ctccggattc tctggcccaa cacggtggaa gctctgcaag    13680

ggcgcagaga cagaatgcgg cagaaattgc ccccgagtcc caactctcct ttccttgcga    13740

ccttgggaac aagacttaaa ggagcctgtg acttagaaac ttctagtaat gggtacctgg    13800

gagtcgtttg agtatggggc agtgatttat tctctgtgat ggatgccaac acggttaaac    13860

agaattttta gtttttatat gtgtgtgatg ctgctccccc aaattgttaa ctgtgtaaga    13920

gggtggcaaa atagggaaag tggcattcac ctatagttcc agcattcagg aagctgaggc    13980

aggaggattg taaatttgag gccagtctga gctgtaaggt gagaccctat ttcaaacaac    14040

acagccagaa ttgggttctg gtaaatcata cttaacaagg gaaaaatgca agacgcaaga    14100

ccgtggcaag gaaatgacgc tttgcccaac gaaatgtagg aaaccaacat agactcccag    14160

tttgtccctc tttatgtctg gtctccctaa caacgatctt tgctaatgag aaaaatatta    14220

gaaaaaaata tccctgtgca attatcaccc agtcgccatt ataatgcaat taaaaggccc    14280

acaagaaatc ctgtatacac gaccgttatt tattgtatgt aagttgctga ggaagaggag    14340

aaaaaaataa agatcatcca ttccttcctg catctatccc tgttttttat gttgctgcgt    14400

ggcatctatt ctgaaatatt aaagtgggtg cctgaagttt cataaatttg aaactttaga    14460

gattactata tatctgcact cgtcattgtg atcatccaaa atcgtaatga ttatggctcg    14520

gcagctgtgc tcttgatttt tagcaactcc cacccccacc cccaccccca cccccacccc    14580

caacccccac cctgcgtgca gcaagttcat cctggcttat tttaaatcaa ctgaattcga    14640

gattaaaatg tgaaagtttt ggagatgaac tactgaataa aatgatgtcg ggaaaaagca    14700

tttatatatt aaagtcatac agatcacagg gaaggtggcg catgtattta acccccagca    14760

ttggaaagat ggaggcagga ggctctctgt gggtttgagg tcagcctgat ctagacagag    14820

tgctccgcag atagccacac agagagagcc tgccttagag aaataaatac ctgatgaaat    14880

agaattgaat tgagagtcca gaaattaacc cactcagcta tgaccaactg atttcagata    14940

aaggtccaag gtgtactgag tcagcaaacc ctgctggggc aatctgacat caggtgcaaa    15000

gagtgcagtc cacatggtga cacctgcctg tcccctactc gggaggctga gacaagaaga    15060

tcagtagtag ttgcagtaaa tctccaccca aatatgccct ggcaatgaaa acacaactca    15120

attaatatga atacatgctg tgcgcctaga ttgggcagat ctaccgctgc actaccatct    15180

tctccatcta tgagaccctt tagaacttgc ggtttctaag gtttgggggt ataattagcc    15240

ccagggctat ccacaacact gtcctaggcg catttcctaa acacgagctt attcataagc    15300

ccagccagag ggttcacatt gcccacaaca caccctcctt tcctaccaca taaccaaagc    15360

ccaaactcta gaactggttc taactgggaa ttctcatggc atcccatagc atataccccc    15420

ttctctgcag tgagcaatat gtccagtatt tcctggaaac cattggtaca caaaactctg    15480

agtcaccaac acccgctgct ctgtctactg aactggcttc caatgttaac taattcattt    15540

gagtgtgtgt attagtgtga gtgtgtgtta gttacttttg ctgttgttgt gattaaaaca    15600

ccatgaccaa gggcaaccta aggaagagag cgtgtgtatc ttggcttatg ccactgagaa    15660

cgaagccatc actgtggggt ggaggcatgg cttcaagtgt caggcatgac gtgaggagca    15720

ggaagctggg agatcacatc tttaacagcg agtgccaagc agagagggaa actggaagtt    15780

aaagcccaca agtgatgtgc tccctcagcc aggctgcact tcctgaacac cccaaaacag    15840

cgccacctac ctagaaccga ctttgaatat ctgagcctat ggggacattt gtcattctaa    15900

ccactgttgt gcactgttgt tgcacagtga gccatcttgc cagctcatat tccacaattt    15960

gtatttcatt ttaccaatgc tctctctgta gtagtgataa tgatgactgt tccctttttt    16020

ggttttgctt cgttttgaga tttcagtatt tttctcaagt tttattttaa gtgatgttaa    16080

ttacagcgtt tgaaggggag gagctaattc cactcaaaat ggaagactct ataatgtacc    16140

cattaaactg ctaaaaaaaa aataataata ataatggtaa gtctacaaga ggagtcagtt    16200

tagaccccta gtgttgtcag agtgtgacca caatcacctg cccagatcag agccagagaa    16260

cccggaagct atttcatact ctggtgcaat gggggggggg ggggggggag aaattttaaa    16320

aaaacaaaaa ggaggaagaa aaacacacac acaacacaag gaagaattaa gtcctgattg    16380

actgactcca tcttgcccac cctctccacc ctaaaatggc acaaaagaaa ataccacacc    16440

taaagactac ttttggtgta aaacaggtaa ctgatgggct aggatgggaa cagggtatga    16500

tgatctgtct aaaaaaatgt tcctttcacg aaggtgtgta cgtacttctg agcagatagg    16560

atcgggacac cagggttcaa tgcttgggaa gtcacaattt catctgggga ctggatacag    16620

atttacaaag ggtccacaca ttcccagctt ccatttgcag cctggcatct ctagaggctc    16680

ctccccaagc cccaacccac acctacagct agaaaggacc ctttctggaa tggggtttct    16740

gctgtacctc tgaaatggta aacaccttaa agctgagtca tccttagcct ggagaggcat    16800

tcatcaactc tcgcatcccc aacatacaat attaaaagtc cactaaattg gtagctatgt    16860

tgcaaaatag ttcaaaatta acgattttac aatattcatt tatgcttgaa attctagtcc    16920

taagccaagc ttgtgtctgc cagcattgat gttcttgcgt ccagtagggc tgacaatgtc    16980

agtttgatac ctggttttag gatctgagtg taccctaagc caatcaggct ggagttgttc    17040

actttgccag aaaagcaggc atcagggtgg aactgaaatt tggctgctat tccaaagcga    17100

gtgttactgt tttctgcagt ccaggcgaga ttgacagcag tctccaactt cttgttcgcc    17160

ttctggtaaa tggaaccacc aaactctgtc ccgtcgtatg aagctgtctt gctctgggtc    17220

actcaggact tcgaggtctc aaaattcatc tggtagccag ctagccaacc ctcatagcca    17280

agcaccggat tgagggccca gcgatgtcaa agtccacgcc acagcccaag ttgatgtgct    17340

ccctcttgta ccctgtcatg atttttagca ttttccccca agttttgggt gaaaaagatg    17400

aatcgaaggt cagcttcagt ccacaagcaa gctggtctcc cacggtgatc tcagtgccca    17460

gggtgctgtc tgtgttccac ttctccgtaa atgtttgccc atactcagtc catctgtcct    17520

tggtttccag actgccgttc actctggtgg tctccgtgtt ggcagagcct gagctggtaa    17580

attccaatct attcttggac ttcgttttca aatcaagttt tattaagcca aagcggtagc    17640

ccttggtgaa gacatccctg atggatagag gcagctgcga tggggggttg cagcgaggat    17700

gctgggagcg cagcgaatag gcagagggcg gggcagctct cacgattgtt tcttaagaag    17760

acttccttta aaattaatac taatccacta actactcact cattcttcca ggattttact    17820

gatcaattgc tgtatacgca tagcgccgcg gtcatcgtta cacagacgtg ttaagcacac    17880

aaagactgct ttgaagaagg ctgaaagatc tcggggctgg agagagaact ctgcagttta    17940

cagagcttct tggtcctcca gagaacccaa tttcagttcc cagcatccac atcacacagc    18000

tcacaaccgc cggaaactcc agctccagag ggtccaacac ccctgttctg gcctccagga    18060

gcacctacat acatgtgtca tgcaaacaca cacacaaaca cacaacacac acatacatac    18120

ataaattaaa aatatatata aataaatcaa tccttttttt ttaaagcagt cttaaaatct    18180

gtggacctag agaagtatta tctgaaattt tgaaatggga cccaaagaac gtcttctcac    18240

aggaactaat acttacagtc ttttgaagca taggtaaatg ttcaatcggt gatgataaac    18300

ctagagactg agactgcagc caggctggga gaggacttgt ccagcatgcg ctaagtccag    18360

tgctcagccc ac                                                        18372


<210>  24
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 1

<400>  24
acaataataa tcagagctga aggaagacta tggtgacaga gaagccttgc cctgactttc       60

ttctccaact cacagctgtg acggaagatc acttcg                                 96


<210>  25
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2

<400>  25
caccaggggc agccatagct ttagtgtcaa cagctgccac ccaccccctc cccaaccccg       60

caaccccccc cccacctgag gttcttatgg ctcttg                                 96


<210>  26
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 3

<400>  26
cccacaagca tcccaaatgg cctgggtggg agagcatgca ggtcacgtca ccagtgctct       60

ctgctctttc tccagctgtg acggaagatc acttcg                                 96


<210>  27
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 4

<400>  27
cccaccccca gtttccccgc tgacactcac tctgagtggc aactcagacc gctctctcca       60

gtgtgcaagt ctcacctgag gttcttatgg ctcttg                                 96


<210>  28
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 5

<400>  28
acacacacac acacacacac acacacacac acacacacac ctccttctta tttatctatt       60

tatttttctt ttaagctgtg acggaagatc acttcg                                 96


<210>  29
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 6

<400>  29
gagagagaga gagacagaga cagacagaga gacagagaca gacagagaga caggcagaca       60

gacaggcaga cttacctgag gttcttatgg ctcttg                                 96


<210>  30
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 7

<400>  30
gtttagacac tttcctttcc agagatcaaa tttaaagccc ttcactccgt ttatatcatc       60

tctctttctc cacagctgtg acggaagatc acttcg                                 96


<210>  31
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 8

<400>  31
ccagtagatg gcgatgttgc acagcaagct cagttacatc attgctctgg cggtcctgtg       60

cagctcaagt attttctgag gttcttatgg ctcttg                                 96


<210>  32
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 9

<400>  32
cccacaagca tcccaaatgg cctgggtggg agagcatgca ggtcacgtca ccagtgctct       60

ctgctctttc tccagaacgg ctgccacgct gagatgctct tcctgcg                    107


<210>  33
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 10

<400>  33
cccaccccca gtttccccgc tgacactcac tctgagtggc aactcagacc gctctctcca       60

gtgtgcaagt ctcacctttg tagctcatga cagacagtc                              99


<210>  34
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 11

<400>  34
aggcaaagcc tccatccaga caggcagcca gcactactgg agcacatgca caagcagatg       60

agactgtctt gttac                                                        75


<210>  35
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 12

<400>  35
gtttagacac tttcctttcc agagatcaaa tttaaagccc ttcactccgt ttatatcatc       60

tctctttctc cacagccgcc gtacgacatg gagg                                   94


<210>  36
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 13

<400>  36
aggcaaagcc tccatccaga caggcagcca gcactactgg agcacatgca caagcagatg       60

agactgtctt gttacttaaa gcccaagtag aacaaacact tc                         102


<210>  37
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 14

<400>  37
tatgactgtg cccggcacgt ggctgagttt ctgagatgga accctaacct cagcctgagg       60

attttcaccg cgcgcctgtg acggaagatc acttcg                                 96


<210>  38
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 15

<400>  38
cagtgtgcaa gtctcacctt tgaaggtcat gatcccgatc tggaccccag cgcggtgcag       60

tctccgcagc ccctcctgag gttcttatgg ctcttg                                 96


<210>  39
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 16

<400>  39
tatgactgtg cccggcacgt ggctgagttt ctgagatgga accctaacct cagcctgagg       60

attttcaccg cgcgcctcta tttctgcgag gagcg                                  95


<210>  40
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 17

<400>  40
ctttgaaggt catgatcccg atctggaccc cagcgcggtg cagtctccgc agcccctccg       60

gctccgcgtt gcgctcct                                                     78


<210>  41
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  41
ctctacttct gtgaggaccg caaggctgag ccc                                    33


<210>  42
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  42
ctctacttct gtgaagaccg caaggctgag cct                                    33


<210>  43
<211>  33
<212>  DNA
<213>  Gallus gallus

<400>  43
ctctacttct gtgaagatcg caaggctgag cct                                    33


<210>  44
<211>  33
<212>  DNA
<213>  Xenopus laevis

<400>  44
ctctatttct gcgaggagcg caacgcggag ccg                                    33


<210>  45
<211>  36
<212>  DNA
<213>  Ictalurus punctatus

<400>  45
ctctacttct gtgacgagga ggacagtcaa gagaga                                 36


<210>  46
<211>  36
<212>  DNA
<213>  Danio rerio

<400>  46
ctgtacttct gtgatgaaga ggacagcgtg gagaga                                 36


<210>  47
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  47

Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro 
1               5                   10      


<210>  48
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  48

Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro 
1               5                   10      


<210>  49
<211>  11
<212>  PRT
<213>  Gallus gallus

<400>  49

Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro 
1               5                   10      


<210>  50
<211>  11
<212>  PRT
<213>  Xenopus laevis

<400>  50

Leu Tyr Phe Cys Glu Glu Arg Asn Ala Glu Pro 
1               5                   10      


<210>  51
<211>  12
<212>  PRT
<213>  Ictalurus punctatus

<400>  51

Leu Tyr Phe Cys Asp Glu Glu Asp Ser Gln Glu Arg 
1               5                   10          


<210>  52
<211>  12
<212>  PRT
<213>  Danio rerio

<400>  52

Leu Tyr Phe Cys Asp Glu Glu Asp Ser Val Glu Arg 
1               5                   10          


<210>  53
<211>  597
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimaeric AID (mouse AID with Xenopus exon 3)

<400>  53
atggacagcc ttctgatgaa gcaaaagaag tttctttacc atttcaaaaa tgtccgctgg       60

gccaagggac ggcatgagac ctacctctgc tacgtggtga agaggagaga tagtgccacc      120

tcctgctcac tggacttcgg ccaccttcgc aacaagaacg gctgccacgc tgagatgctc      180

ttcctgcgct acctgtctat atgggtgggt cacgaccccc ataggaacta ccgggtcacg      240

tggttcagct cctggagccc ctgctatgac tgtgccaagc gcaccctcga gttcttaaag      300

gggcacccca acttcagtct gcgcatcttc agcgccaggc tctatttctg cgaggagcgc      360

aacgcggagc cggaggggct gcggaaactg cagaaagcgg gggtgcgact gtctgtcatg      420

agctacaact atttttactg ctggaataca tttgtagaaa atcgtgaaag aactttcaaa      480

gcctgggaag ggctacatga aaattctgtc cggctaacca gacaacttcg gcgcatcctt      540

ttgcccttgt acgaagtcga tgacttgcga gatgcatttc gtatgttggg attttga         597


<210>  54
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimaeric AID (mouse AID with Xenopus exon 3)

<400>  54

Met Asp Ser Leu Leu Met Lys Gln Lys Lys Phe Leu Tyr His Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Cys Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Asn Gly Cys His Ala Glu Met Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Leu Ser Ile Trp Val Gly His Asp Pro His Arg Asn Tyr Arg Val Thr 
65                  70                  75                  80  


Trp Phe Ser Ser Trp Ser Pro Cys Tyr Asp Cys Ala Lys Arg Thr Leu 
                85                  90                  95      


Glu Phe Leu Lys Gly His Pro Asn Phe Ser Leu Arg Ile Phe Ser Ala 
            100                 105                 110         


Arg Leu Tyr Phe Cys Glu Glu Arg Asn Ala Glu Pro Glu Gly Leu Arg 
        115                 120                 125             


Lys Leu Gln Lys Ala Gly Val Arg Leu Ser Val Met Ser Tyr Asn Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn Arg Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Thr Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Met Leu Gly Phe 
        195             


<210>  55
<211>  597
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimaeric AID (mouse AID with Xenopus active-site loop)

<400>  55
atggacagcc ttctgatgaa gcaaaagaag tttctttacc atttcaaaaa tgtccgctgg       60

gccaagggac ggcatgagac ctacctctgc tacgtggtga agaggagaga tagtgccacc      120

tcctgctcac tggacttcgg ccaccttcgc aacaagtctg gctgccacgt ggaattgttg      180

ttcctacgct acatctcaga ctgggacctg gacccgggcc ggtgttaccg cgtcacctgg      240

ttcacctcct ggagcccgtg ctatgactgt gcccggcacg tggctgagtt tctgagatgg      300

aaccctaacc tcagcctgag gattttcacc gcgcgcctct atttctgcga ggagcgcaac      360

gcggagccgg aggggctgcg gagactgcac cgcgctgggg tccagatcgg gatcatgacc      420

ttcaaagact atttttactg ctggaataca tttgtagaaa atcgtgaaag aactttcaaa      480

gcctgggaag ggctacatga aaattctgtc cggctaacca gacaacttcg gcgcatcctt      540

ttgcccttgt acgaagtcga tgacttgcga gatgcatttc gtatgttggg attttga         597


<210>  56
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimaeric AID (mouse AID with Xenopus active-site loop)

<400>  56

Met Asp Ser Leu Leu Met Lys Gln Lys Lys Phe Leu Tyr His Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Cys Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ser Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Glu 
                85                  90                  95      


Phe Leu Arg Trp Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Glu Arg Asn Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Gly Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn Arg Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Thr Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Met Leu Gly Phe 
        195             


<210>  57
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimaeric AID (mouse AID with catfish active-site loop)

<400>  57
atggacagcc ttctgatgaa gcaaaagaag tttctttacc atttcaaaaa tgtccgctgg       60

gccaagggac ggcatgagac ctacctctgc tacgtggtga agaggagaga tagtgccacc      120

tcctgctcac tggacttcgg ccaccttcgc aacaagtctg gctgccacgt ggaattgttg      180

ttcctacgct acatctcaga ctgggacctg gacccgggcc ggtgttaccg cgtcacctgg      240

ttcacctcct ggagcccgtg ctatgactgt gcccggcacg tggctgagtt tctgagatgg      300

aaccctaacc tcagcctgag gattttcacc gcgcgcctct acttctgtga cgaggaggac      360

agtcaagaga gagaggggct gcggagactg caccgcgctg gggtccagat cgggatcatg      420

accttcaaag actattttta ctgctggaat acatttgtag aaaatcgtga aagaactttc      480

aaagcctggg aagggctaca tgaaaattct gtccggctaa ccagacaact tcggcgcatc      540

cttttgccct tgtacgaagt cgatgacttg cgagatgcat ttcgtatgtt gggattttga      600


<210>  58
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimaeric AID (mouse AID with catfish active-site loop)

<400>  58

Met Asp Ser Leu Leu Met Lys Gln Lys Lys Phe Leu Tyr His Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Cys Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ser Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Glu 
                85                  90                  95      


Phe Leu Arg Trp Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Asp Glu Glu Asp Ser Gln Glu Arg Glu Gly Leu Arg 
        115                 120                 125             


Arg Leu His Arg Ala Gly Val Gln Ile Gly Ile Met Thr Phe Lys Asp 
    130                 135                 140                 


Tyr Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn Arg Glu Arg Thr Phe 
145                 150                 155                 160 


Lys Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Thr Arg Gln 
                165                 170                 175     


Leu Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp 
            180                 185                 190         


Ala Phe Arg Met Leu Gly Phe 
        195                 


<210>  59
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 18

<400>  59
aggcgaattc tccatgaaag tcaggctggc                                        30


<210>  60
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 19

<400>  60
gttagaatga cgatatcgga tccatgctag tctggaaatc tc                          42


<210>  61
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 20

<400>  61
tggatccgat atcgtcattc taaccactgt tgtgcac                                37


<210>  62
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 21

<400>  62
aggcacgcgt ctaaactgac tcctcttgta gac                                    33


<210>  63
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 22

<400>  63
aggcacgcgt ctaaactgac tcctcttgta gac                                    33


<210>  64
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 23

<400>  64
aggcacgcgt ctaaactgac tcctcttgta gac                                    33


<210>  65
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 24

<400>  65
aggcgaattc tttcttagac gtcaggtggc ac                                     32


<210>  66
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 25

<400>  66
aggcacgcgt cgatacgcga gcgaacgtga                                        30


<210>  67
<211>  75
<212>  DNA
<213>  Mus musculus

<400>  67
tatgactgtg cccggcacgt ggctgagttt ctgagatgga accctaacct cagcctgagg       60

attttcaccg cgcgc                                                        75


<210>  68
<211>  58
<212>  DNA
<213>  Mus musculus

<400>  68
gaggggctgc ggagactgca ccgcgctggg gtccagatcg ggatcatgac cttcaaag         58


