                         LISTADO DE SECUENCIAS

<110>  Servicio Andaluz de Salud
<110>  Universidad de Granada
 
<120>  Mtodo de obtencin de datos tiles para el diagnstico del 
       cncer de pncreas y para evaluar la respuesta al tratamiento.

<130>  PCT-04895

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Ser Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Met Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser 
    50                  55                  60                  


Ala Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln 
                85                  90                  95      


Thr Asp Arg Met Asn Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Ser Ser His Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly 
        115                 120                 125             


Ser Asp Gly Arg Leu Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Val Phe Asp Tyr Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala 
305                 310                 315                 320 


Val Val Thr Gly Ala Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Asp 
        


<210>  2
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Pro Arg Thr Arg Lys Val Leu Lys Glu Val Arg Val Gln 
1               5                   10                  15      


Asp Glu Asn Asn Val Cys Phe Glu Cys Gly Ala Phe Asn Pro Gln Trp 
            20                  25                  30          


Val Ser Val Thr Tyr Gly Ile Trp Ile Cys Leu Glu Cys Ser Gly Arg 
        35                  40                  45              


His Arg Gly Leu Gly Val His Leu Ser Phe Val Arg Ser Val Thr Met 
    50                  55                  60                  


Asp Lys Trp Lys Asp Ile Glu Leu Glu Lys Met Lys Ala Gly Gly Asn 
65                  70                  75                  80  


Ala Lys Phe Arg Glu Phe Leu Glu Ser Gln Glu Asp Tyr Asp Pro Cys 
                85                  90                  95      


Trp Ser Leu Gln Glu Lys Tyr Asn Ser Arg Ala Ala Ala Leu Phe Arg 
            100                 105                 110         


Asp Lys Val Val Ala Leu Ala Glu Gly Arg Glu Trp Ser Leu Glu Ser 
        115                 120                 125             


Ser Pro Ala Gln Asn Trp Thr Pro Pro Gln Pro Arg Thr Leu Pro Ser 
    130                 135                 140                 


Met Val His Arg Val Ser Gly Gln Pro Gln Ser Val Thr Ala Ser Ser 
145                 150                 155                 160 


Asp Lys Ala Phe Glu Asp Trp Leu Asn Asp Asp Leu Gly Ser Tyr Gln 
                165                 170                 175     


Gly Ala Gln Gly Asn Arg Tyr Val Gly Phe Gly Asn Thr Pro Pro Pro 
            180                 185                 190         


Gln Lys Lys Glu Asp Asp Phe Leu Asn Asn Ala Met Ser Ser Leu Tyr 
        195                 200                 205             


Ser Gly Trp Ser Ser Phe Thr Thr Gly Ala Ser Arg Phe Ala Ser Ala 
    210                 215                 220                 


Ala Lys Glu Gly Ala Thr Lys Phe Gly Ser Gln Ala Ser Gln Lys Ala 
225                 230                 235                 240 


Ser Glu Leu Gly His Ser Leu Asn Glu Asn Val Leu Lys Pro Ala Gln 
                245                 250                 255     


Glu Lys Val Lys Glu Gly Lys Ile Phe Asp Asp Val Ser Ser Gly Val 
            260                 265                 270         


Ser Gln Leu Ala Ser Lys Val Gln Gly Val Gly Ser Lys Gly Trp Arg 
        275                 280                 285             


Asp Val Thr Thr Phe Phe Ser Gly Lys Ala Glu Gly Pro Leu Asp Ser 
    290                 295                 300                 


Pro Ser Glu Gly His Ser Tyr Gln Asn Ser Gly Leu Asp His Phe Gln 
305                 310                 315                 320 


Asn Ser Asn Ile Asp Gln Ser Phe Trp Glu Thr Phe Gly Ser Ala Glu 
                325                 330                 335     


Pro Thr Lys Thr Arg Lys Ser Pro Ser Ser Asp Ser Trp Thr Cys Ala 
            340                 345                 350         


Asp Thr Ser Thr Glu Arg Arg Ser Ser Asp Ser Trp Glu Val Trp Gly 
        355                 360                 365             


Ser Ala Ser Thr Asn Arg Asn Ser Asn Ser Asp Gly Gly Glu Gly Gly 
    370                 375                 380                 


Glu Gly Thr Lys Lys Ala Val Pro Pro Ala Val Pro Thr Asp Asp Gly 
385                 390                 395                 400 


Trp Asp Asn Gln Asn Trp 
                405     


<210>  3
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Cys Ser Ser Leu Glu Gln Ala Leu Ala Val Leu Val Thr Thr Phe 
1               5                   10                  15      


His Lys Tyr Ser Cys Gln Glu Gly Asp Lys Phe Lys Leu Ser Lys Gly 
            20                  25                  30          


Glu Met Lys Glu Leu Leu His Lys Glu Leu Pro Ser Phe Val Gly Glu 
        35                  40                  45              


Lys Val Asp Glu Glu Gly Leu Lys Lys Leu Met Gly Ser Leu Asp Glu 
    50                  55                  60                  


Asn Ser Asp Gln Gln Val Asp Phe Gln Glu Tyr Ala Val Phe Leu Ala 
65                  70                  75                  80  


Leu Ile Thr Val Met Cys Asn Asp Phe Phe Gln Gly Cys Pro Asp Arg 
                85                  90                  95      


Pro 
    


<210>  4
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Gly Ser Pro Gly Asp Ala Glu Arg Arg Gln Arg Trp Gly Arg 
1               5                   10                  15      


Leu Phe Glu Glu Leu Asp Ser Asn Lys Asp Gly Arg Val Asp Val His 
            20                  25                  30          


Glu Leu Arg Gln Gly Leu Ala Arg Leu Gly Gly Gly Asn Pro Asp Pro 
        35                  40                  45              


Gly Ala Gln Gln Gly Ile Ser Ser Glu Gly Asp Ala Asp Pro Asp Gly 
    50                  55                  60                  


Gly Leu Asp Leu Glu Glu Phe Ser Arg Tyr Leu Gln Glu Arg Glu Gln 
65                  70                  75                  80  


Arg Leu Leu Leu Met Phe His Ser Leu Asp Arg Asn Gln Asp Gly His 
                85                  90                  95      


Ile Asp Val Ser Glu Ile Gln Gln Ser Phe Arg Ala Leu Gly Ile Ser 
            100                 105                 110         


Ile Ser Leu Glu Gln Ala Glu Lys Ile Leu His Ser Met Asp Arg Asp 
        115                 120                 125             


Gly Thr Met Thr Ile Asp Trp Gln Glu Trp Arg Asp His Phe Leu Leu 
    130                 135                 140                 


His Ser Leu Glu Asn Val Glu Asp Val Leu Tyr Phe Trp Lys His Ser 
145                 150                 155                 160 


Thr Val Leu Asp Ile Gly Glu Cys Leu Thr Val Pro Asp Glu Phe Ser 
                165                 170                 175     


Lys Gln Glu Lys Leu Thr Gly Met Trp Trp Lys Gln Leu Val Ala Gly 
            180                 185                 190         


Ala Val Ala Gly Ala Val Ser Arg Thr Gly Thr Ala Pro Leu Asp Arg 
        195                 200                 205             


Leu Lys Val Phe Met Gln Val His Ala Ser Lys Thr Asn Arg Leu Asn 
    210                 215                 220                 


Ile Leu Gly Gly Leu Arg Ser Met Val Leu Glu Gly Gly Ile Arg Ser 
225                 230                 235                 240 


Leu Trp Arg Gly Asn Gly Ile Asn Val Leu Lys Ile Ala Pro Glu Ser 
                245                 250                 255     


Ala Ile Lys Phe Met Ala Tyr Glu Gln Ile Lys Arg Ala Ile Leu Gly 
            260                 265                 270         


Gln Gln Glu Thr Leu His Val Gln Glu Arg Phe Val Ala Gly Ser Leu 
        275                 280                 285             


Ala Gly Ala Thr Ala Gln Thr Ile Ile Tyr Pro Met Glu Val Leu Lys 
    290                 295                 300                 


Thr Arg Leu Thr Leu Arg Arg Thr Gly Gln Tyr Lys Gly Leu Leu Asp 
305                 310                 315                 320 


Cys Ala Arg Arg Ile Leu Glu Arg Glu Gly Pro Arg Ala Phe Tyr Arg 
                325                 330                 335     


Gly Tyr Leu Pro Asn Val Leu Gly Ile Ile Pro Tyr Ala Gly Ile Asp 
            340                 345                 350         


Leu Ala Val Tyr Glu Thr Leu Lys Asn Trp Trp Leu Gln Gln Tyr Ser 
        355                 360                 365             


His Asp Ser Ala Asp Pro Gly Ile Leu Val Leu Leu Ala Cys Gly Thr 
    370                 375                 380                 


Ile Ser Ser Thr Cys Gly Gln Ile Ala Ser Tyr Pro Leu Ala Leu Val 
385                 390                 395                 400 


Arg Thr Arg Met Gln Ala Gln Ala Ser Ile Glu Gly Gly Pro Gln Leu 
                405                 410                 415     


Ser Met Leu Gly Leu Leu Arg His Ile Leu Ser Gln Glu Gly Met Arg 
            420                 425                 430         


Gly Leu Tyr Arg Gly Ile Ala Pro Asn Phe Met Lys Val Ile Pro Ala 
        435                 440                 445             


Val Ser Ile Ser Tyr Val Val Tyr Glu Asn Met Lys Gln Ala Leu Gly 
    450                 455                 460                 


Val Thr Ser Arg 
465             


<210>  5
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Thr Asp Ser Val Ile Tyr Ser Met Leu Glu Leu Pro Thr Ala Thr 
1               5                   10                  15      


Gln Ala Gln Asn Asp Tyr Gly Pro Gln Gln Lys Ser Ser Ser Ser Arg 
            20                  25                  30          


Pro Ser Cys Ser Cys Leu Val Ala Ile Ala Leu Gly Leu Leu Thr Ala 
        35                  40                  45              


Val Leu Leu Ser Val Leu Leu Tyr Gln Trp Ile Leu Cys Gln Gly Ser 
    50                  55                  60                  


Asn Tyr Ser Thr Cys Ala Ser Cys Pro Ser Cys Pro Asp Arg Trp Met 
65                  70                  75                  80  


Lys Tyr Gly Asn His Cys Tyr Tyr Phe Ser Val Glu Glu Lys Asp Trp 
                85                  90                  95      


Asn Ser Ser Leu Glu Phe Cys Leu Ala Arg Asp Ser His Leu Leu Val 
            100                 105                 110         


Ile Thr Asp Asn Gln Glu Met Ser Leu Leu Gln Val Phe Leu Ser Glu 
        115                 120                 125             


Ala Phe Cys Trp Ile Gly Leu Arg Asn Asn Ser Gly Trp Arg Trp Glu 
    130                 135                 140                 


Asp Gly Ser Pro Leu Asn Phe Ser Arg Ile Ser Ser Asn Ser Phe Val 
145                 150                 155                 160 


Gln Thr Cys Gly Ala Ile Asn Lys Asn Gly Leu Gln Ala Ser Ser Cys 
                165                 170                 175     


Glu Val Pro Leu His Trp Val Cys Lys Lys Val Arg Leu 
            180                 185                 


<210>  6
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gln Pro Ile Leu Leu Leu Leu Ala Phe Leu Leu Leu Pro Arg Ala 
1               5                   10                  15      


Asp Ala Gly Glu Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Tyr Leu Met Ile Trp Asp Gln Lys Ser Leu Lys Arg 
        35                  40                  45              


Cys Gly Gly Phe Leu Ile Arg Asp Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  


Cys Trp Gly Ser Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys 
65                  70                  75                  80  


Glu Gln Glu Pro Thr Gln Gln Phe Ile Pro Val Lys Arg Pro Ile Pro 
                85                  90                  95      


His Pro Ala Tyr Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu 
            100                 105                 110         


Gln Leu Glu Arg Lys Ala Lys Arg Thr Arg Ala Val Gln Pro Leu Arg 
        115                 120                 125             


Leu Pro Ser Asn Lys Ala Gln Val Lys Pro Gly Gln Thr Cys Ser Val 
    130                 135                 140                 


Ala Gly Trp Gly Gln Thr Ala Pro Leu Gly Lys His Ser His Thr Leu 
145                 150                 155                 160 


Gln Glu Val Lys Met Thr Val Gln Glu Asp Arg Lys Cys Glu Ser Asp 
                165                 170                 175     


Leu Arg His Tyr Tyr Asp Ser Thr Ile Glu Leu Cys Val Gly Asp Pro 
            180                 185                 190         


Glu Ile Lys Lys Thr Ser Phe Lys Gly Asp Ser Gly Gly Pro Leu Val 
        195                 200                 205             


Cys Asn Lys Val Ala Gln Gly Ile Val Ser Tyr Gly Arg Asn Asn Gly 
    210                 215                 220                 


Met Pro Pro Arg Ala Cys Thr Lys Val Ser Ser Phe Val His Trp Ile 
225                 230                 235                 240 


Lys Lys Thr Met Lys Arg Tyr 
                245         


<210>  7
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Leu Pro Gly Val Gly Val Phe Gly Thr Ser Leu Thr Ala Arg Val 
1               5                   10                  15      


Ile Ile Pro Leu Leu Lys Asp Glu Gly Phe Ala Val Lys Ala Leu Trp 
            20                  25                  30          


Gly Arg Thr Gln Glu Glu Ala Glu Glu Leu Ala Lys Glu Met Ser Val 
        35                  40                  45              


Pro Phe Tyr Thr Ser Arg Ile Asp Glu Val Leu Leu His Gln Asp Val 
    50                  55                  60                  


Asp Leu Val Cys Ile Asn Leu Pro Pro Pro Leu Thr Arg Gln Ile Ala 
65                  70                  75                  80  


Val Lys Thr Leu Gly Ile Gly Lys Asn Val Ile Cys Asp Arg Thr Ala 
                85                  90                  95      


Thr Pro Leu Asp Ala Phe Arg Met Thr Ser Ala Ala His Tyr Tyr Pro 
            100                 105                 110         


Lys Leu Met Ser Ile Met Gly Asn Val Leu Arg Phe Leu Pro Ala Phe 
        115                 120                 125             


Val Arg Met Lys Gln Leu Ile Glu Glu Gly Tyr Val Gly Glu Pro Leu 
    130                 135                 140                 


Val Cys Glu Val Gln Val His Gly Gly Ser Leu Leu Gly Lys Lys Tyr 
145                 150                 155                 160 


Asn Trp Ser Cys Asp Asp Leu Met Gly Gly Gly Gly Leu His Ser Val 
                165                 170                 175     


Gly Thr Tyr Ile Ile Asp Leu Leu Thr Phe Leu Thr Gly Gln Lys Ala 
            180                 185                 190         


Val Lys Val His Gly Leu Leu Lys Thr Phe Val Lys Gln Thr Asp His 
        195                 200                 205             


Ile Lys Gly Ile Arg Gln Ile Thr Ser Asp Asp Phe Cys Thr Phe Gln 
    210                 215                 220                 


Met Val Leu Glu Gly Gly Val Cys Cys Thr Val Thr Leu Asn Phe Asn 
225                 230                 235                 240 


Val Pro Gly Glu Phe Lys Gln Asp Val Thr Val Val Gly Ser Ala Gly 
                245                 250                 255     


Arg Leu Leu Ala Val Gly Thr Asp Leu Tyr Gly Gln Arg Asn Ser Ala 
            260                 265                 270         


Pro Glu Gln Glu Leu Leu Val Gln Asp Ala Thr Pro Val Ser Asn Ser 
        275                 280                 285             


Leu Leu Pro Glu Lys Ala Phe Ser Asp Ile Pro Ser Pro Tyr Leu Arg 
    290                 295                 300                 


Gly Thr Ile Lys Met Met Gln Ala Val Arg Gln Ala Phe Gln Asp Gln 
305                 310                 315                 320 


Asp Asp Arg Arg Thr Trp Asp Gly Arg Pro Leu Thr Met Ala Ala Thr 
                325                 330                 335     


Phe Asp Asp Cys Leu Tyr Ala Leu Cys Val Val Asp Thr Ile Lys Arg 
            340                 345                 350         


Ser Ser Gln Thr Gly Glu Trp Gln Asn Ile Ala Ile Met Thr Glu Glu 
        355                 360                 365             


Pro Glu Leu Ser Pro Ala Tyr Leu Ile Ser Glu Ala Met Arg Arg Ser 
    370                 375                 380                 


Arg Met Ser Leu Tyr Cys 
385                 390 


<210>  8
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Ala Leu Thr Arg Asp Pro Gln Phe Gln Lys Leu Gln Gln Trp 
1               5                   10                  15      


Tyr Arg Glu His Arg Ser Glu Leu Asn Leu Arg Arg Leu Phe Asp Ala 
            20                  25                  30          


Asn Lys Asp Arg Phe Asn His Phe Ser Leu Thr Leu Asn Thr Asn His 
        35                  40                  45              


Gly His Ile Leu Val Asp Tyr Ser Lys Asn Leu Val Thr Glu Asp Val 
    50                  55                  60                  


Met Arg Met Leu Val Asp Leu Ala Lys Ser Arg Gly Val Glu Ala Ala 
65                  70                  75                  80  


Arg Glu Arg Met Phe Asn Gly Glu Lys Ile Asn Tyr Thr Glu Gly Arg 
                85                  90                  95      


Ala Val Leu His Val Ala Leu Arg Asn Arg Ser Asn Thr Pro Ile Leu 
            100                 105                 110         


Val Asp Gly Lys Asp Val Met Pro Glu Val Asn Lys Val Leu Asp Lys 
        115                 120                 125             


Met Lys Ser Phe Cys Gln Arg Val Arg Ser Gly Asp Trp Lys Gly Tyr 
    130                 135                 140                 


Thr Gly Lys Thr Ile Thr Asp Val Ile Asn Ile Gly Ile Gly Gly Ser 
145                 150                 155                 160 


Asp Leu Gly Pro Leu Met Val Thr Glu Ala Leu Lys Pro Tyr Ser Ser 
                165                 170                 175     


Gly Gly Pro Arg Val Trp Tyr Val Ser Asn Ile Asp Gly Thr His Ile 
            180                 185                 190         


Ala Lys Thr Leu Ala Gln Leu Asn Pro Glu Ser Ser Leu Phe Ile Ile 
        195                 200                 205             


Ala Ser Lys Thr Phe Thr Thr Gln Glu Thr Ile Thr Asn Ala Glu Thr 
    210                 215                 220                 


Ala Lys Glu Trp Phe Leu Gln Ala Ala Lys Asp Pro Ser Ala Val Ala 
225                 230                 235                 240 


Lys His Phe Val Ala Leu Ser Thr Asn Thr Thr Lys Val Lys Glu Phe 
                245                 250                 255     


Gly Ile Asp Pro Gln Asn Met Phe Glu Phe Trp Asp Trp Val Gly Gly 
            260                 265                 270         


Arg Tyr Ser Leu Trp Ser Ala Ile Gly Leu Ser Ile Ala Leu His Val 
        275                 280                 285             


Gly Phe Asp Asn Phe Glu Gln Leu Leu Ser Gly Ala His Trp Met Asp 
    290                 295                 300                 


Gln His Phe Arg Thr Thr Pro Leu Glu Lys Asn Ala Pro Val Leu Leu 
305                 310                 315                 320 


Ala Leu Leu Gly Ile Trp Tyr Ile Asn Cys Phe Gly Cys Glu Thr His 
                325                 330                 335     


Ala Met Leu Pro Tyr Asp Gln Tyr Leu His Arg Phe Ala Ala Tyr Phe 
            340                 345                 350         


Gln Gln Gly Asp Met Glu Ser Asn Gly Lys Tyr Ile Thr Lys Ser Gly 
        355                 360                 365             


Thr Arg Val Asp His Gln Thr Gly Pro Ile Val Trp Gly Glu Pro Gly 
    370                 375                 380                 


Thr Asn Gly Gln His Ala Phe Tyr Gln Leu Ile His Gln Gly Thr Lys 
385                 390                 395                 400 


Met Ile Pro Cys Asp Phe Leu Ile Pro Val Gln Thr Gln His Pro Ile 
                405                 410                 415     


Arg Lys Gly Leu His His Lys Ile Leu Leu Ala Asn Phe Leu Ala Gln 
            420                 425                 430         


Thr Glu Ala Leu Met Arg Gly Lys Ser Thr Glu Glu Ala Arg Lys Glu 
        435                 440                 445             


Leu Gln Ala Ala Gly Lys Ser Pro Glu Asp Leu Glu Arg Leu Leu Pro 
    450                 455                 460                 


His Lys Val Phe Glu Gly Asn Arg Pro Thr Asn Ser Ile Val Phe Thr 
465                 470                 475                 480 


Lys Leu Thr Pro Phe Met Leu Gly Ala Leu Val Ala Met Tyr Glu His 
                485                 490                 495     


Lys Ile Phe Val Gln Gly Ile Ile Trp Asp Ile Asn Ser Phe Asp Gln 
            500                 505                 510         


Trp Gly Val Glu Leu Gly Lys Gln Leu Ala Lys Lys Ile Glu Pro Glu 
        515                 520                 525             


Leu Asp Gly Ser Ala Gln Val Thr Ser His Asp Ala Ser Thr Asn Gly 
    530                 535                 540                 


Leu Ile Asn Phe Ile Lys Gln Gln Arg Glu Ala Arg Val Gln 
545                 550                 555             


<210>  9
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Thr Ala Ala His Asn Ala Ser Val Asp Met 
                165                 170                 175     


Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His 
            180                 185                 190         


Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln Gln 
        195                 200                 205             


Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Val Arg Phe Met Gly Asp 
    210                 215                 220                 


Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala Thr Val Trp Lys Leu 
225                 230                 235                 240 


Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln Glu 
                245                 250                 255     


Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val Leu Leu Pro Arg Thr 
            260                 265                 270         


Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu Ala Glu Lys Arg Leu 
        275                 280                 285             


Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe Gln Asp Lys Asn Ser 
    290                 295                 300                 


Ser Gln Val Leu Gly Glu Lys Val Leu Gly Ile Val Val Gln Asn Thr 
305                 310                 315                 320 


Lys Val Ala Asn Leu Thr Glu Pro Val Val Leu Thr Phe Gln His Gln 
                325                 330                 335     


Leu Gln Pro Lys Asn Val Thr Leu Gln Cys Val Phe Trp Val Glu Asp 
            340                 345                 350         


Pro Thr Leu Ser Ser Pro Gly His Trp Ser Ser Ala Gly Cys Glu Thr 
        355                 360                 365             


Val Arg Arg Glu Thr Gln Thr Ser Cys Phe Cys Asn His Leu Thr Tyr 
    370                 375                 380                 


Phe Ala Val Leu Met Val Ser Ser Val Glu Val Asp Ala Val His Lys 
385                 390                 395                 400 


His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys Val Val Ser Ala Leu 
                405                 410                 415     


Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu Cys Ser Arg Arg Lys Pro 
            420                 425                 430         


Arg Asp Tyr Thr Ile Lys Val His Met Asn Leu Leu Leu Ala Val Phe 
        435                 440                 445             


Leu Leu Asp Thr Ser Phe Leu Leu Ser Glu Pro Val Ala Leu Thr Gly 
    450                 455                 460                 


Ser Glu Ala Gly Cys Arg Ala Ser Ala Ile Phe Leu His Phe Ser Leu 
465                 470                 475                 480 


Leu Thr Cys Leu Ser Trp Met Gly Leu Glu Gly Tyr Asn Leu Tyr Arg 
                485                 490                 495     


Leu Val Val Glu Val Phe Gly Thr Tyr Val Pro Gly Tyr Leu Leu Lys 
            500                 505                 510         


Leu Ser Ala Met Gly Trp Gly Phe Pro Ile Phe Leu Val Thr Leu Val 
        515                 520                 525             


Ala Leu Val Asp Val Asp Asn Tyr Gly Pro Ile Ile Leu Ala Val His 
    530                 535                 540                 


Arg Thr Pro Glu Gly Val Ile Tyr Pro Ser Met Cys Trp Ile Arg Asp 
545                 550                 555                 560 


Ser Leu Val Ser Tyr Ile Thr Asn Leu Gly Leu Phe Ser Leu Val Phe 
                565                 570                 575     


Leu Phe Asn Met Ala Met Leu Ala Thr Met Val Val Gln Ile Leu Arg 
            580                 585                 590         


Leu Arg Pro His Thr Gln Lys Trp Ser His Val Leu Thr Leu Leu Gly 
        595                 600                 605             


Leu Ser Leu Val Leu Gly Leu Pro Trp Ala Leu Ile Phe Phe Ser Phe 
    610                 615                 620                 


Ala Ser Gly Thr Phe Gln Leu Val Val Leu Tyr Leu Phe Ser Ile Ile 
625                 630                 635                 640 


Thr Ser Phe Gln Gly Phe Leu Ile Phe Ile Trp Tyr Trp Ser Met Arg 
                645                 650                 655     


Leu Gln Ala Arg Gly Gly Pro Ser Pro Leu Lys Ser Asn Ser Asp Ser 
            660                 665                 670         


Ala Arg Leu Pro Ile Ser Ser Gly Ser Thr Ser Ser Ser Arg Ile 
        675                 680                 685         


<210>  10
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Cys Leu Trp Gly Leu Ala Leu Pro Leu Phe Phe Phe Cys Trp 
1               5                   10                  15      


Glu Val Gly Val Ser Gly Ser Ser Ala Gly Pro Ser Thr Arg Arg Ala 
            20                  25                  30          


Asp Thr Ala Met Thr Thr Asp Asp Thr Glu Val Pro Ala Met Thr Leu 
        35                  40                  45              


Ala Pro Gly His Ala Ala Leu Glu Thr Gln Thr Leu Ser Ala Glu Thr 
    50                  55                  60                  


Ser Ser Arg Ala Ser Thr Pro Ala Gly Pro Ile Pro Glu Ala Glu Thr 
65                  70                  75                  80  


Arg Gly Ala Lys Arg Ile Ser Pro Ala Arg Glu Thr Arg Ser Phe Thr 
                85                  90                  95      


Lys Thr Ser Pro Asn Phe Met Val Leu Ile Ala Thr Ser Val Glu Thr 
            100                 105                 110         


Ser Ala Ala Ser Gly Ser Pro Glu Gly Ala Gly Met Thr Thr Val Gln 
        115                 120                 125             


Thr Ile Thr Gly Ser Asp Pro Arg Glu Ala Ile Phe Asp Thr Leu Cys 
    130                 135                 140                 


Thr Asp Asp Ser Ser Glu Glu Ala Lys Thr Leu Thr Met Asp Ile Leu 
145                 150                 155                 160 


Thr Leu Ala His Thr Ser Thr Glu Ala Lys Gly Leu Ser Ser Glu Ser 
                165                 170                 175     


Ser Ala Ser Ser Asp Ser Pro His Pro Val Ile Thr Pro Ser Arg Ala 
            180                 185                 190         


Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val Ile Thr Pro 
        195                 200                 205             


Ser Arg Ala Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val 
    210                 215                 220                 


Ile Thr Pro Ser Trp Ser Pro Gly Ser Asp Val Thr Leu Leu Ala Glu 
225                 230                 235                 240 


Ala Leu Val Thr Val Thr Asn Ile Glu Val Ile Asn Cys Ser Ile Thr 
                245                 250                 255     


Glu Ile Glu Thr Thr Thr Ser Ser Ile Pro Gly Ala Ser Asp Thr Asp 
            260                 265                 270         


Leu Ile Pro Thr Glu Gly Val Lys Ala Ser Ser Thr Ser Asp Pro Pro 
        275                 280                 285             


Ala Leu Pro Asp Ser Thr Glu Ala Lys Pro His Ile Thr Glu Val Thr 
    290                 295                 300                 


Ala Ser Ala Glu Thr Leu Ser Thr Ala Gly Thr Thr Glu Ser Ala Ala 
305                 310                 315                 320 


Pro Asp Ala Thr Val Gly Thr Pro Leu Pro Thr Asn Ser Ala Thr Glu 
                325                 330                 335     


Arg Glu Val Thr Ala Pro Gly Ala Thr Thr Leu Ser Gly Ala Leu Val 
            340                 345                 350         


Thr Val Ser Arg Asn Pro Leu Glu Glu Thr Ser Ala Leu Ser Val Glu 
        355                 360                 365             


Thr Pro Ser Tyr Val Lys Val Ser Gly Ala Ala Pro Val Ser Ile Glu 
    370                 375                 380                 


Ala Gly Ser Ala Val Gly Lys Thr Thr Ser Phe Ala Gly Ser Ser Ala 
385                 390                 395                 400 


Ser Ser Tyr Ser Pro Ser Glu Ala Ala Leu Lys Asn Phe Thr Pro Ser 
                405                 410                 415     


Glu Thr Pro Thr Met Asp Ile Ala Thr Lys Gly Pro Phe Pro Thr Ser 
            420                 425                 430         


Arg Asp Pro Leu Pro Ser Val Pro Pro Thr Thr Thr Asn Ser Ser Arg 
        435                 440                 445             


Gly Thr Asn Ser Thr Leu Ala Lys Ile Thr Thr Ser Ala Lys Thr Thr 
    450                 455                 460                 


Met Lys Pro Pro Thr Ala Thr Pro Thr Thr Ala Arg Thr Arg Pro Thr 
465                 470                 475                 480 


Thr Asp Val Ser Ala Gly Glu Asn Gly Gly Phe Leu Leu Leu Arg Leu 
                485                 490                 495     


Ser Val Ala Ser Pro Glu Asp Leu Thr Asp Pro Arg Val Ala Glu Arg 
            500                 505                 510         


Leu Met Gln Gln Leu His Arg Glu Leu His Ala His Ala Pro His Phe 
        515                 520                 525             


Gln Val Ser Leu Leu Arg Val Arg Arg Gly 
    530                 535             


<210>  11
<211>  833
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Asp Val Val Asp Pro Asp Ile Phe Asn Arg Asp Pro Arg Asp His 
1               5                   10                  15      


Tyr Asp Leu Leu Gln Arg Leu Gly Gly Gly Thr Tyr Gly Glu Val Phe 
            20                  25                  30          


Lys Ala Arg Asp Lys Val Ser Gly Asp Leu Val Ala Leu Lys Met Val 
        35                  40                  45              


Lys Met Glu Pro Asp Asp Asp Val Ser Thr Leu Gln Lys Glu Ile Leu 
    50                  55                  60                  


Ile Leu Lys Thr Cys Arg His Ala Asn Ile Val Ala Tyr His Gly Ser 
65                  70                  75                  80  


Tyr Leu Trp Leu Gln Lys Leu Trp Ile Cys Met Glu Phe Cys Gly Ala 
                85                  90                  95      


Gly Ser Leu Gln Asp Ile Tyr Gln Val Thr Gly Ser Leu Ser Glu Leu 
            100                 105                 110         


Gln Ile Ser Tyr Val Cys Arg Glu Val Leu Gln Gly Leu Ala Tyr Leu 
        115                 120                 125             


His Ser Gln Lys Lys Ile His Arg Asp Ile Lys Gly Ala Asn Ile Leu 
    130                 135                 140                 


Ile Asn Asp Ala Gly Glu Val Arg Leu Ala Asp Phe Gly Ile Ser Ala 
145                 150                 155                 160 


Gln Ile Gly Ala Thr Leu Ala Arg Arg Leu Ser Phe Ile Gly Thr Pro 
                165                 170                 175     


Tyr Trp Met Ala Pro Glu Val Ala Ala Val Ala Leu Lys Gly Gly Tyr 
            180                 185                 190         


Asn Glu Leu Cys Asp Ile Trp Ser Leu Gly Ile Thr Ala Ile Glu Leu 
        195                 200                 205             


Ala Glu Leu Gln Pro Pro Leu Phe Asp Val His Pro Leu Arg Val Leu 
    210                 215                 220                 


Phe Leu Met Thr Lys Ser Gly Tyr Gln Pro Pro Arg Leu Lys Glu Lys 
225                 230                 235                 240 


Gly Lys Trp Ser Ala Ala Phe His Asn Phe Ile Lys Val Thr Leu Thr 
                245                 250                 255     


Lys Ser Pro Lys Lys Arg Pro Ser Ala Thr Lys Met Leu Ser His Gln 
            260                 265                 270         


Leu Val Ser Gln Pro Gly Leu Asn Arg Gly Leu Ile Leu Asp Leu Leu 
        275                 280                 285             


Asp Lys Leu Lys Asn Pro Gly Lys Gly Pro Ser Ile Gly Asp Ile Glu 
    290                 295                 300                 


Asp Glu Glu Pro Glu Leu Pro Pro Ala Ile Pro Arg Arg Ile Arg Ser 
305                 310                 315                 320 


Thr His Arg Ser Ser Ser Leu Gly Ile Pro Asp Ala Asp Cys Cys Arg 
                325                 330                 335     


Arg His Met Glu Phe Arg Lys Leu Arg Gly Met Glu Thr Arg Pro Pro 
            340                 345                 350         


Ala Asn Thr Ala Arg Leu Gln Pro Pro Arg Asp Leu Arg Ser Ser Ser 
        355                 360                 365             


Pro Arg Lys Gln Leu Ser Glu Ser Ser Asp Asp Asp Tyr Asp Asp Val 
    370                 375                 380                 


Asp Ile Pro Thr Pro Ala Glu Asp Thr Pro Pro Pro Leu Pro Pro Lys 
385                 390                 395                 400 


Pro Lys Phe Arg Ser Pro Ser Asp Glu Gly Pro Gly Ser Met Gly Asp 
                405                 410                 415     


Asp Gly Gln Leu Ser Pro Gly Val Leu Val Arg Cys Ala Ser Gly Pro 
            420                 425                 430         


Pro Pro Asn Ser Pro Arg Pro Gly Pro Pro Pro Ser Thr Ser Ser Pro 
        435                 440                 445             


His Leu Thr Ala His Ser Glu Pro Ser Leu Trp Asn Pro Pro Ser Arg 
    450                 455                 460                 


Glu Leu Asp Lys Pro Pro Leu Leu Pro Pro Lys Lys Glu Lys Met Lys 
465                 470                 475                 480 


Arg Lys Gly Cys Ala Leu Leu Val Lys Leu Phe Asn Gly Cys Pro Leu 
                485                 490                 495     


Arg Ile His Ser Thr Ala Ala Trp Thr His Pro Ser Thr Lys Asp Gln 
            500                 505                 510         


His Leu Leu Leu Gly Ala Glu Glu Gly Ile Phe Ile Leu Asn Arg Asn 
        515                 520                 525             


Asp Gln Glu Ala Thr Leu Glu Met Leu Phe Pro Ser Arg Thr Thr Trp 
    530                 535                 540                 


Val Tyr Ser Ile Asn Asn Val Leu Met Ser Leu Ser Gly Lys Thr Pro 
545                 550                 555                 560 


His Leu Tyr Ser His Ser Ile Leu Gly Leu Leu Glu Arg Lys Glu Thr 
                565                 570                 575     


Arg Ala Gly Asn Pro Ile Ala His Ile Ser Pro His Arg Leu Leu Ala 
            580                 585                 590         


Arg Lys Asn Met Val Ser Thr Lys Ile Gln Asp Thr Lys Gly Cys Arg 
        595                 600                 605             


Ala Cys Cys Val Ala Glu Gly Ala Ser Ser Gly Gly Pro Phe Leu Cys 
    610                 615                 620                 


Gly Ala Leu Glu Thr Ser Val Val Leu Leu Gln Trp Tyr Gln Pro Met 
625                 630                 635                 640 


Asn Lys Phe Leu Leu Val Arg Gln Val Leu Phe Pro Leu Pro Thr Pro 
                645                 650                 655     


Leu Ser Val Phe Ala Leu Leu Thr Gly Pro Gly Ser Glu Leu Pro Ala 
            660                 665                 670         


Val Cys Ile Gly Val Ser Pro Gly Arg Pro Gly Lys Ser Val Leu Phe 
        675                 680                 685             


His Thr Val Arg Phe Gly Ala Leu Ser Cys Trp Leu Gly Glu Met Ser 
    690                 695                 700                 


Thr Glu His Arg Gly Pro Val Gln Val Thr Gln Val Glu Glu Asp Met 
705                 710                 715                 720 


Val Met Val Leu Met Asp Gly Ser Val Lys Leu Val Thr Pro Glu Gly 
                725                 730                 735     


Ser Pro Val Arg Gly Leu Arg Thr Pro Glu Ile Pro Met Thr Glu Ala 
            740                 745                 750         


Val Glu Ala Val Ala Met Val Gly Gly Gln Leu Gln Ala Phe Trp Lys 
        755                 760                 765             


His Gly Val Gln Val Trp Ala Leu Gly Ser Asp Gln Leu Leu Gln Glu 
    770                 775                 780                 


Leu Arg Asp Pro Thr Leu Thr Phe Arg Leu Leu Gly Ser Pro Arg Leu 
785                 790                 795                 800 


Glu Cys Ser Gly Thr Ile Ser Pro His Cys Asn Leu Leu Leu Pro Gly 
                805                 810                 815     


Ser Ser Asn Ser Pro Ala Ser Ala Ser Arg Val Ala Gly Ile Thr Gly 
            820                 825                 830         


Leu 
    


<210>  12
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Val His Leu Thr Pro Glu Glu Lys Thr Ala Val Asn Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Ala Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Ser Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ser Gln Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala Arg Asn Phe Gly Lys Glu Phe Thr Pro Gln Met Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  13
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Thr Glu Trp Glu Thr Ala Ala Pro Ala Val Ala Glu Thr Pro Asp 
1               5                   10                  15      


Ile Lys Leu Phe Gly Lys Trp Ser Thr Asp Asp Val Gln Ile Asn Asp 
            20                  25                  30          


Ile Ser Leu Gln Asp Tyr Ile Ala Val Lys Glu Lys Tyr Ala Lys Tyr 
        35                  40                  45              


Leu Pro His Ser Ala Gly Arg Tyr Ala Ala Lys Arg Phe Arg Lys Ala 
    50                  55                  60                  


Gln Cys Pro Ile Val Glu Arg Leu Thr Asn Ser Met Met Met His Gly 
65                  70                  75                  80  


Arg Asn Asn Gly Lys Lys Leu Met Thr Val Arg Ile Val Lys His Ala 
                85                  90                  95      


Phe Glu Ile Ile His Leu Leu Thr Gly Glu Asn Pro Leu Gln Val Leu 
            100                 105                 110         


Val Asn Ala Ile Ile Asn Ser Gly Pro Arg Glu Asp Ser Thr Arg Ile 
        115                 120                 125             


Gly Arg Ala Gly Thr Val Arg Arg Gln Ala Val Asp Val Ser Pro Leu 
    130                 135                 140                 


Arg Arg Val Asn Gln Ala Ile Trp Leu Leu Cys Thr Gly Ala Arg Glu 
145                 150                 155                 160 


Ala Ala Phe Arg Asn Ile Lys Thr Ile Ala Glu Cys Leu Ala Asp Glu 
                165                 170                 175     


Leu Ile Asn Ala Ala Lys Gly Ser Ser Asn Ser Tyr Ala Ile Lys Lys 
            180                 185                 190         


Lys Asp Glu Leu Glu Arg Val Ala Lys Ser Asn Arg 
        195                 200                 


<210>  14
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Ser His Leu Val Glu Pro Pro Pro Pro Leu His Asn Asn Asn 
1               5                   10                  15      


Asn Asn Cys Glu Glu Asn Glu Gln Ser Leu Pro Pro Pro Ala Gly Leu 
            20                  25                  30          


Asn Ser Ser Trp Val Glu Leu Pro Met Asn Ser Ser Asn Gly Asn Asp 
        35                  40                  45              


Asn Gly Asn Gly Lys Asn Gly Gly Leu Glu His Val Pro Ser Ser Ser 
    50                  55                  60                  


Ser Ile His Asn Gly Asp Met Glu Lys Ile Leu Leu Asp Ala Gln His 
65                  70                  75                  80  


Glu Ser Gly Gln Ser Ser Ser Arg Gly Ser Ser His Cys Asp Ser Pro 
                85                  90                  95      


Ser Pro Gln Glu Asp Gly Gln Ile Met Phe Asp Val Glu Met His Thr 
            100                 105                 110         


Ser Arg Asp His Ser Ser Gln Ser Glu Glu Glu Val Val Glu Gly Glu 
        115                 120                 125             


Lys Glu Val Glu Ala Leu Lys Lys Ser Ala Asp Trp Val Ser Asp Trp 
    130                 135                 140                 


Ser Ser Arg Pro Glu Asn Ile Pro Pro Lys Glu Phe His Phe Arg His 
145                 150                 155                 160 


Pro Lys Arg Ser Val Ser Leu Ser Met Arg Lys Ser Gly Ala Met Lys 
                165                 170                 175     


Lys Gly Gly Ile Phe Ser Ala Glu Phe Leu Lys Val Phe Ile Pro Ser 
            180                 185                 190         


Leu Phe Leu Ser His Val Leu Ala Leu Gly Leu Gly Ile Tyr Ile Gly 
        195                 200                 205             


Lys Arg Leu Ser Thr Pro Ser Ala Ser Thr Tyr 
    210                 215                 


<210>  15
<211>  1203
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Asp Leu Arg Asp Phe Tyr Leu Leu Ala Ala Leu Ile Ala Cys Leu 
1               5                   10                  15      


Arg Leu Asp Ser Ala Ile Ala Gln Glu Leu Ile Tyr Thr Ile Arg Glu 
            20                  25                  30          


Glu Leu Pro Glu Asn Val Pro Ile Gly Asn Ile Pro Lys Asp Leu Asn 
        35                  40                  45              


Ile Ser His Ile Asn Ala Ala Thr Gly Thr Ser Ala Ser Leu Val Tyr 
    50                  55                  60                  


Arg Leu Val Ser Lys Ala Gly Asp Ala Pro Leu Val Lys Val Ser Ser 
65                  70                  75                  80  


Ser Thr Gly Glu Ile Phe Thr Thr Ser Asn Arg Ile Asp Arg Glu Lys 
                85                  90                  95      


Leu Cys Ala Gly Ala Ser Tyr Ala Glu Glu Asn Glu Cys Phe Phe Glu 
            100                 105                 110         


Leu Glu Val Val Ile Leu Pro Asn Asp Phe Phe Arg Leu Ile Lys Ile 
        115                 120                 125             


Lys Ile Ile Val Lys Asp Thr Asn Asp Asn Ala Pro Met Phe Pro Ser 
    130                 135                 140                 


Pro Val Ile Asn Ile Ser Ile Pro Glu Asn Thr Leu Ile Asn Ser Arg 
145                 150                 155                 160 


Phe Pro Ile Pro Ser Ala Thr Asp Pro Asp Thr Gly Phe Asn Gly Val 
                165                 170                 175     


Gln His Tyr Glu Leu Leu Asn Gly Gln Ser Val Phe Gly Leu Asp Ile 
            180                 185                 190         


Val Glu Thr Pro Glu Gly Glu Lys Trp Pro Gln Leu Ile Val Gln Gln 
        195                 200                 205             


Asn Leu Asp Arg Glu Gln Lys Asp Thr Tyr Val Met Lys Ile Lys Val 
    210                 215                 220                 


Glu Asp Gly Gly Thr Pro Gln Lys Ser Ser Thr Ala Ile Leu Gln Val 
225                 230                 235                 240 


Thr Val Ser Asp Val Asn Asp Asn Arg Pro Val Phe Lys Glu Gly Gln 
                245                 250                 255     


Val Glu Val His Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Ile 
            260                 265                 270         


Gln Leu His Ala Thr Asp Ala Asp Ile Gly Ser Asn Ala Glu Ile Arg 
        275                 280                 285             


Tyr Ile Phe Gly Ala Gln Val Ala Pro Ala Thr Lys Arg Leu Phe Ala 
    290                 295                 300                 


Leu Asn Asn Thr Thr Gly Leu Ile Thr Val Gln Arg Ser Leu Asp Arg 
305                 310                 315                 320 


Glu Glu Thr Ala Ile His Lys Val Thr Val Leu Ala Ser Asp Gly Ser 
                325                 330                 335     


Ser Thr Pro Ala Arg Ala Thr Val Thr Ile Asn Val Thr Asp Val Asn 
            340                 345                 350         


Asp Asn Pro Pro Asn Ile Asp Leu Arg Tyr Ile Ile Ser Pro Ile Asn 
        355                 360                 365             


Gly Thr Val Tyr Leu Ser Glu Lys Asp Pro Val Asn Thr Lys Ile Ala 
    370                 375                 380                 


Leu Ile Thr Val Ser Asp Lys Asp Thr Asp Val Asn Gly Lys Val Ile 
385                 390                 395                 400 


Cys Phe Ile Glu Arg Glu Val Pro Phe His Leu Lys Ala Val Tyr Asp 
                405                 410                 415     


Asn Gln Tyr Leu Leu Glu Thr Ser Ser Leu Leu Asp Tyr Glu Gly Thr 
            420                 425                 430         


Lys Glu Phe Ser Phe Lys Ile Val Ala Ser Asp Ser Gly Lys Pro Ser 
        435                 440                 445             


Leu Asn Gln Thr Ala Leu Val Arg Val Lys Leu Glu Asp Glu Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ile Phe Asn Gln Pro Val Ile Glu Leu Ser Val Ser Glu 
465                 470                 475                 480 


Asn Asn Arg Arg Gly Leu Tyr Leu Thr Thr Ile Ser Ala Thr Asp Glu 
                485                 490                 495     


Asp Ser Gly Lys Asn Ala Asp Ile Val Tyr Gln Leu Gly Pro Asn Ala 
            500                 505                 510         


Ser Phe Phe Asp Leu Asp Arg Lys Thr Gly Val Leu Thr Ala Ser Arg 
        515                 520                 525             


Val Phe Asp Arg Glu Glu Gln Glu Arg Phe Ile Phe Thr Val Thr Ala 
    530                 535                 540                 


Arg Asp Asn Gly Thr Pro Pro Leu Gln Ser Gln Ala Ala Val Ile Val 
545                 550                 555                 560 


Thr Val Leu Asp Glu Asn Asp Asn Ser Pro Lys Phe Thr His Asn His 
                565                 570                 575     


Phe Gln Phe Phe Val Ser Glu Asn Leu Pro Lys Tyr Ser Thr Val Gly 
            580                 585                 590         


Val Ile Thr Val Thr Asp Ala Asp Ala Gly Glu Asn Lys Ala Val Thr 
        595                 600                 605             


Leu Ser Ile Leu Asn Asp Asn Asp Asn Phe Val Leu Asp Pro Tyr Ser 
    610                 615                 620                 


Gly Val Ile Lys Ser Asn Val Ser Phe Asp Arg Glu Gln Gln Ser Ser 
625                 630                 635                 640 


Tyr Thr Phe Asp Val Lys Ala Thr Asp Gly Gly Gln Pro Pro Arg Ser 
                645                 650                 655     


Ser Thr Ala Lys Val Thr Ile Asn Val Met Asp Val Asn Asp Asn Ser 
            660                 665                 670         


Pro Val Val Ile Ser Pro Pro Ser Asn Thr Ser Phe Lys Leu Val Pro 
        675                 680                 685             


Leu Ser Ala Ile Pro Gly Ser Val Val Ala Glu Val Phe Ala Val Asp 
    690                 695                 700                 


Val Asp Thr Gly Met Asn Ala Glu Leu Lys Tyr Thr Ile Val Ser Gly 
705                 710                 715                 720 


Asn Asn Lys Gly Leu Phe Arg Ile Asp Pro Val Thr Gly Asn Ile Thr 
                725                 730                 735     


Leu Glu Glu Lys Pro Ala Pro Thr Asp Val Gly Leu His Arg Leu Val 
            740                 745                 750         


Val Asn Ile Ser Asp Leu Gly Tyr Pro Lys Ser Leu His Thr Leu Val 
        755                 760                 765             


Leu Val Phe Leu Tyr Val Asn Asp Thr Ala Gly Asn Ala Ser Tyr Ile 
    770                 775                 780                 


Tyr Asp Leu Ile Arg Arg Thr Met Glu Thr Pro Leu Asp Arg Asn Ile 
785                 790                 795                 800 


Gly Asp Ser Ser Gln Pro Tyr Gln Asn Glu Asp Tyr Leu Thr Ile Met 
                805                 810                 815     


Ile Ala Ile Ile Ala Gly Ala Met Val Val Ile Val Val Ile Phe Val 
            820                 825                 830         


Thr Val Leu Val Arg Cys Arg His Ala Ser Arg Phe Lys Ala Ala Gln 
        835                 840                 845             


Arg Ser Lys Gln Gly Ala Glu Trp Met Ser Pro Asn Gln Glu Asn Lys 
    850                 855                 860                 


Gln Asn Lys Lys Lys Lys Arg Lys Lys Arg Lys Ser Pro Lys Ser Ser 
865                 870                 875                 880 


Leu Leu Asn Phe Val Thr Ile Glu Glu Ser Lys Pro Asp Asp Ala Val 
                885                 890                 895     


His Glu Pro Ile Asn Gly Thr Ile Ser Leu Pro Ala Glu Leu Glu Glu 
            900                 905                 910         


Gln Ser Ile Gly Arg Phe Asp Trp Gly Pro Ala Pro Pro Thr Thr Phe 
        915                 920                 925             


Lys Pro Asn Ser Pro Asp Leu Ala Lys His Tyr Lys Ser Ala Ser Pro 
    930                 935                 940                 


Gln Pro Ala Phe His Leu Lys Pro Asp Thr Pro Val Ser Val Lys Lys 
945                 950                 955                 960 


His His Val Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Gly Gly 
                965                 970                 975     


Cys Asp Thr Leu Ser Lys Arg Ser Ser Thr Ser Ser Asp His Phe Ser 
            980                 985                 990         


Ala Ser Glu Cys Ser Ser Gln Gly  Gly Phe Lys Thr Lys  Gly Pro Leu 
        995                 1000                 1005             


His Thr  Arg Gln Ser Gln Arg  Arg Val Thr Phe His  Leu Pro Asp 
    1010                 1015                 1020             


Gly Ser  Gln Glu Ser Cys Ser  Asp Ser Gly Leu Gly  Asp His Glu 
    1025                 1030                 1035             


Pro Val  Gly Ser Gly Thr Leu  Ile Ser His Pro Leu  Pro Leu Val 
    1040                 1045                 1050             


Gln Pro  Gln Asp Glu Phe Tyr  Asp Gln Ala Ser Pro  Asp Lys Arg 
    1055                 1060                 1065             


Thr Glu  Ala Asp Gly Asn Ser  Asp Pro Asn Ser Asp  Gly Pro Leu 
    1070                 1075                 1080             


Gly Pro  Arg Gly Leu Ala Glu  Ala Thr Glu Met Cys  Thr Gln Glu 
    1085                 1090                 1095             


Cys Leu  Val Leu Gly His Ser  Asp Asn Cys Trp Met  Pro Pro Gly 
    1100                 1105                 1110             


Leu Gly  Pro Tyr Gln His Pro  Lys Ser Pro Leu Ser  Thr Phe Ala 
    1115                 1120                 1125             


Pro Gln  Lys Glu Trp Val Lys  Lys Asp Lys Leu Val  Asn Gly His 
    1130                 1135                 1140             


Thr Leu  Thr Arg Ala Trp Lys  Glu Asp Ser Asn Arg  Asn Gln Phe 
    1145                 1150                 1155             


Asn Asp  Arg Lys Gln Tyr Gly  Ser Asn Glu Gly His  Phe Asn Asn 
    1160                 1165                 1170             


Gly Ser  His Met Thr Asp Ile  Pro Leu Ala Asn Leu  Lys Ser Tyr 
    1175                 1180                 1185             


Lys Gln  Ala Gly Gly Ala Thr  Glu Ser Pro Lys Glu  His Gln Leu 
    1190                 1195                 1200             


<210>  16
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Val Glu Ile Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Lys Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Gln 
            20                  25                  30          


Asn Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Arg Ile Gly Lys Gln Glu Val Ile Lys Gly Phe Glu Glu Gly Ala 
    50                  55                  60                  


Ala Gln Met Ser Leu Gly Gln Arg Ala Lys Leu Thr Cys Thr Pro Asp 
65                  70                  75                  80  


Val Ala Tyr Gly Ala Thr Gly His Pro Gly Val Ile Pro Pro Asn Ala 
                85                  90                  95      


Thr Leu Ile Phe Asp Val Glu Leu Leu Asn Leu Glu 
            100                 105             


