                         SEQUENCE LISTING

<110>  Novartis AG
       Richards, Hanno
       Mpofu, Shephard
       Thangavelu, Karthinathan
 
<120>  METHODS OF TREATING RHEUMATOID ARTHRITIS USING IL-17 BINDING 
       MOLECULES

<130>  54388

<140>  Herewith
<141>  Herewith

<150>  61/410,533
<151>  2010-11-05

<160>  17    

<170>  PatentIn version 3.3

<210>  1
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CDR1 = hypervariable region 1 of heavy chain of AIN457

<400>  1

Asn Tyr Trp Met Asn 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  CDR2 = hypervariable region 2 of heavy chain of AIN457

<400>  2

Ala Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Gly Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  18
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  CDR3 = hypervariable region 3 of heavy chain of AIN457

<400>  3

Asp Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr Ile His Tyr Trp Tyr Phe 
1               5                   10                  15      


Asp Leu 
        


<210>  4
<211>  12
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  CDR1' = hypervariable region 1 of light chain of AIN457

<400>  4

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  5
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  CDR2' = hypervariable region 2 of light chain AIN457

<400>  5

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  CDR3' = hypervariable region 3 of light chain AIN457

<400>  6

Gln Gln Tyr Gly Ser Ser Pro Cys Thr 
1               5                   


<210>  7
<211>  381
<212>  DNA
<213>  HOMO SAPIENS


<220>
<221>  CDS
<222>  (1)..(381)

<400>  7
gag gtg cag ttg gtg gag tct ggg gga ggc ttg gtc cag cct ggg ggg       48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly         
1               5                   10                  15              

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agt aac tat       96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr         
            20                  25                  30                  

tgg atg aac tgg gtc cgc cag gct cca ggg aaa ggg ctg gag tgg gtg      144
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val         
        35                  40                  45                      

gcc gcc ata aac caa gat gga agt gag aaa tac tat gtg ggc tct gtg      192
Ala Ala Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Gly Ser Val         
    50                  55                  60                          

aag ggc cga ttc acc atc tcc aga gac aac gcc aag aac tca ctg tat      240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr         
65                  70                  75                  80          

ctg caa atg aac agc ctg aga gtc gag gac acg gct gtg tat tac tgt      288
Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gtg agg gac tat tac gat att ttg acc gat tat tac atc cac tat tgg      336
Val Arg Asp Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr Ile His Tyr Trp         
            100                 105                 110                 

tac ttc gat ctc tgg ggc cgt ggc acc ctg gtc act gtc tcc tca          381
Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser             
        115                 120                 125                     


<210>  8
<211>  127
<212>  PRT
<213>  HOMO SAPIENS

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr Ile His Tyr Trp 
            100                 105                 110         


Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  9
<211>  327
<212>  DNA
<213>  HOMO SAPIENS


<220>
<221>  CDS
<222>  (1)..(327)

<400>  9
gaa att gtg ttg acg cag tct cca ggc acc ctg tct ttg tct cca ggg       48
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly         
1               5                   10                  15              

gaa aga gcc acc ctc tcc tgc agg gcc agt cag agt gtt agc agc agc       96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser         
            20                  25                  30                  

tac tta gcc tgg tac cag cag aaa cct ggc cag gct ccc agg ctc ctc      144
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu         
        35                  40                  45                      

atc tat ggt gca tcc agc agg gcc act ggc atc cca gac agg ttc agt      192
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser         
    50                  55                  60                          

ggc agt ggg tct ggg aca gac ttc act ctc acc atc agc aga ctg gag      240
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu         
65                  70                  75                  80          

cct gaa gat ttt gca gtg tat tac tgt cag cag tat ggt agc tca ccg      288
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro         
                85                  90                  95              

tgc acc ttc ggc caa ggg aca cga ctg gag att aaa cga                  327
Cys Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg                     
            100                 105                                     


<210>  10
<211>  109
<212>  PRT
<213>  HOMO SAPIENS

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Cys Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
            100                 105                 


<210>  11
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  CDR1-x = hypervariable domain x of heavy chain of AIN457

<400>  11

Gly Phe Thr Phe Ser Asn Tyr Trp Met Asn 
1               5                   10  


<210>  12
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  CDR2-x = hypervariable domain of heavy chain x of AIN457

<400>  12

Ala Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr 
1               5                   10      


<210>  13
<211>  23
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  CDR3-x = hypervariable domain x of heavy chain AIN457

<400>  13

Cys Val Arg Asp Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr Ile His Tyr 
1               5                   10                  15      


Trp Tyr Phe Asp Leu Trp Gly 
            20              


<210>  14
<211>  711
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (1)..(708)

<400>  14
acc atg gaa acc cca gcg gag ctt ctc ttc ctc ctg cta ctc tgg ctc       48
Thr Met Glu Thr Pro Ala Glu Leu Leu Phe Leu Leu Leu Leu Trp Leu         
1               5                   10                  15              

cca gat acc acc gga gaa att gtg ttg acg cag tct cca ggc acc ctg       96
Pro Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu         
            20                  25                  30                  

tct ttg tct cca ggg gaa aga gcc acc ctc tcc tgc agg gcc agt cag      144
Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln         
        35                  40                  45                      

agt gtt agc agc agc tac tta gcc tgg tac cag cag aaa cct ggc cag      192
Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln         
    50                  55                  60                          

gct ccc agg ctc ctc atc tat ggt gca tcc agc agg gcc act ggc atc      240
Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile         
65                  70                  75                  80          

cca gac agg ttc agt ggc agt ggg tct ggg aca gac ttc act ctc acc      288
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr         
                85                  90                  95              

atc agc aga ctg gag cct gaa gat ttt gca gtg tat tac tgt cag cag      336
Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln         
            100                 105                 110                 

tat ggt agc tca ccg tgc acc ttc ggc caa ggg aca cga ctg gag att      384
Tyr Gly Ser Ser Pro Cys Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile         
        115                 120                 125                     

aaa cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat      432
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp         
    130                 135                 140                         

gag cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac      480
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn         
145                 150                 155                 160         

ttc tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc      528
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu         
                165                 170                 175             

caa tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac      576
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp         
            180                 185                 190                 

agc acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac      624
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr         
        195                 200                 205                     

gag aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc      672
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser         
    210                 215                 220                         

tcg ccc gtc aca aag agc ttc aac agg gga gag tgt tag                  711
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                         
225                 230                 235                             


<210>  15
<211>  236
<212>  PRT
<213>  homo sapiens

<400>  15

Thr Met Glu Thr Pro Ala Glu Leu Leu Phe Leu Leu Leu Leu Trp Leu 
1               5                   10                  15      


Pro Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Gly Ser Ser Pro Cys Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  16
<211>  783
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (1)..(780)

<400>  16
acc atg gaa ttg ggg ctg agc tgg gtt ttc ctt gtt gct att tta gaa       48
Thr Met Glu Leu Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Glu         
1               5                   10                  15              

ggt gtc cac tgt gag gtg cag ttg gtg gag tct ggg gga ggc ttg gtc       96
Gly Val His Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val         
            20                  25                  30                  

cag cct ggg ggg tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc      144
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr         
        35                  40                  45                      

ttt agt aac tat tgg atg aac tgg gtc cgc cag gct cca ggg aaa ggg      192
Phe Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly         
    50                  55                  60                          

ctg gag tgg gtg gcc gcc ata aac caa gat gga agt gag aaa tac tat      240
Leu Glu Trp Val Ala Ala Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr         
65                  70                  75                  80          

gtg ggc tct gtg aag ggc cga ttc acc atc tcc aga gac aac gcc aag      288
Val Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys         
                85                  90                  95              

aac tca ctg tat ctg caa atg aac agc ctg aga gtc gag gac acg gct      336
Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala         
            100                 105                 110                 

gtg tat tac tgt gtg agg gac tat tac gat att ttg acc gat tat tac      384
Val Tyr Tyr Cys Val Arg Asp Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr         
        115                 120                 125                     

atc cac tat tgg tac ttc gat ctc tgg ggc cgt ggc acc ctg gtc act      432
Ile His Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr         
    130                 135                 140                         

gtc tcc tca gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc      480
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro         
145                 150                 155                 160         

tcc tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc      528
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val         
                165                 170                 175             

aag gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc      576
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala         
            180                 185                 190                 

ctg acc agc ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga      624
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly         
        195                 200                 205                     

ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc      672
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly         
    210                 215                 220                         

acc cag acc tac atc tgc aac gtg aat cac aag ccc agc aac acc aag      720
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys         
225                 230                 235                 240         

gtg gac aag aga gtt gag ccc aaa tct tgt gac aaa act cac aca tgc      768
Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys         
                245                 250                 255             

cca ccg tgc cca taa                                                  783
Pro Pro Cys Pro                                                         
            260                                                         


<210>  17
<211>  260
<212>  PRT
<213>  homo sapiens

<400>  17

Thr Met Glu Leu Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Glu 
1               5                   10                  15      


Gly Val His Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Ala Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr 
65                  70                  75                  80  


Val Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Val Arg Asp Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr 
        115                 120                 125             


Ile His Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro 
            260 


